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Patent code US10246453

Compile Data Set for Download or QSAR

Found 1146 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM374028
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1ncns1
Show InChI InChI=1/C21H23F2N5O2S2/c1-14-18(27(2)16-8-9-28(12-16)11-15-6-4-3-5-7-15)10-17(22)20(19(14)23)32(29,30)26-21-24-13-25-31-21/h3-7,10,13,16H,8-9,11-12H2,1-2H3,(H,24,25,26)/t16-/s2
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM374029
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Show SMILES CN([C@H]1CCN(Cc2cccc(C)n2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1ncns1
Show InChI InChI=1/C21H24F2N6O2S2/c1-13-5-4-6-15(26-13)10-29-8-7-16(11-29)28(3)18-9-17(22)20(19(23)14(18)2)33(30,31)27-21-24-12-25-32-21/h4-6,9,12,16H,7-8,10-11H2,1-3H3,(H,24,25,27)/t16-/s2
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM374015
PNG
((R)-2,6-difluoro-3-methyl-4-((1-(1-phenylethyl)pip...)
Show SMILES C[C@@H](N1CCC(CC1)Oc1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1)c1ccccc1
Show InChI InChI=1/C23H25F2N3O3S2/c1-15-20(12-19(24)23(22(15)25)33(29,30)27-21-13-32-14-26-21)31-18-8-10-28(11-9-18)16(2)17-6-4-3-5-7-17/h3-7,12-14,16,18,27H,8-11H2,1-2H3/t16-/s2
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM374015
PNG
((R)-2,6-difluoro-3-methyl-4-((1-(1-phenylethyl)pip...)
Show SMILES C[C@@H](N1CCC(CC1)Oc1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1)c1ccccc1
Show InChI InChI=1/C23H25F2N3O3S2/c1-15-20(12-19(24)23(22(15)25)33(29,30)27-21-13-32-14-26-21)31-18-8-10-28(11-9-18)16(2)17-6-4-3-5-7-17/h3-7,12-14,16,18,27H,8-11H2,1-2H3/t16-/s2
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373891
PNG
((S)-4-((1-benzyl-3-methylpyrrolidin-3-yl)oxy)-2,6-...)
Show SMILES Cc1c(F)c(c(F)cc1O[C@@]1(C)CCN(Cc2ccccc2)C1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C22H23F2N3O3S2/c1-15-18(30-22(2)8-9-27(13-22)11-16-6-4-3-5-7-16)10-17(23)21(20(15)24)32(28,29)26-19-12-31-14-25-19/h3-7,10,12,14,26H,8-9,11,13H2,1-2H3/t22-/s2
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373891
PNG
((S)-4-((1-benzyl-3-methylpyrrolidin-3-yl)oxy)-2,6-...)
Show SMILES Cc1c(F)c(c(F)cc1O[C@@]1(C)CCN(Cc2ccccc2)C1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C22H23F2N3O3S2/c1-15-18(30-22(2)8-9-27(13-22)11-16-6-4-3-5-7-16)10-17(23)21(20(15)24)32(28,29)26-19-12-31-14-25-19/h3-7,10,12,14,26H,8-9,11,13H2,1-2H3/t22-/s2
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373956
PNG
(4-((1-benzylpiperidin-4-yl)oxy)-2,6-difluoro-3-met...)
Show SMILES Cc1c(F)c(c(F)cc1OC1CCN(Cc2ccccc2)CC1)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C22H23F2N3O3S2/c1-15-19(30-17-7-10-27(11-8-17)14-16-5-3-2-4-6-16)13-18(23)21(20(15)24)32(28,29)26-22-25-9-12-31-22/h2-6,9,12-13,17H,7-8,10-11,14H2,1H3,(H,25,26)
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM374028
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1ncns1
Show InChI InChI=1/C21H23F2N5O2S2/c1-14-18(27(2)16-8-9-28(12-16)11-15-6-4-3-5-7-15)10-17(22)20(19(14)23)32(29,30)26-21-24-13-25-31-21/h3-7,10,13,16H,8-9,11-12H2,1-2H3,(H,24,25,26)/t16-/s2
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM374029
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Show SMILES CN([C@H]1CCN(Cc2cccc(C)n2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1ncns1
Show InChI InChI=1/C21H24F2N6O2S2/c1-13-5-4-6-15(26-13)10-29-8-7-16(11-29)28(3)18-9-17(22)20(19(23)14(18)2)33(30,31)27-21-24-12-25-32-21/h4-6,9,12,16H,7-8,10-11H2,1-3H3,(H,24,25,27)/t16-/s2
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM374012
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1ccsn1
Show InChI InChI=1/C22H24F2N4O2S2/c1-15-19(27(2)17-8-10-28(14-17)13-16-6-4-3-5-7-16)12-18(23)22(21(15)24)32(29,30)26-20-9-11-31-25-20/h3-7,9,11-12,17H,8,10,13-14H2,1-2H3,(H,25,26)/t17-/s2
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373837
PNG
((S)-2,6-difluoro-3-methyl-4-(methyl(1-((6-methylpy...)
Show SMILES CN(C1CCN(Cc2cccc(C)n2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C22H25F2N5O2S2/c1-14-5-4-6-16(26-14)10-29-8-7-17(11-29)28(3)19-9-18(23)22(21(24)15(19)2)33(30,31)27-20-12-32-13-25-20/h4-6,9,12-13,17,27H,7-8,10-11H2,1-3H3
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM374029
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Show SMILES CN([C@H]1CCN(Cc2cccc(C)n2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1ncns1
Show InChI InChI=1/C21H24F2N6O2S2/c1-13-5-4-6-15(26-13)10-29-8-7-16(11-29)28(3)18-9-17(22)20(19(23)14(18)2)33(30,31)27-21-24-12-25-32-21/h4-6,9,12,16H,7-8,10-11H2,1-3H3,(H,24,25,27)/t16-/s2
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373764
PNG
((S)-3-chloro-4-((1-(3-(difluoromethyl)benzyl)pyrro...)
Show SMILES CN([C@H]1CCN(Cc2cccc(c2)C(F)F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1/C21H22ClF2N5O2S2/c1-28(16-7-8-29(12-16)11-14-3-2-4-15(9-14)20(23)24)19-6-5-17(10-18(19)22)33(30,31)27-21-25-13-26-32-21/h2-6,9-10,13,16,20H,7-8,11-12H2,1H3,(H,25,26,27)/t16-/s2
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373836
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Show SMILES CN(C1CCN(Cc2ccccc2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C22H24F2N4O2S2/c1-15-19(27(2)17-8-9-28(12-17)11-16-6-4-3-5-7-16)10-18(23)22(21(15)24)32(29,30)26-20-13-31-14-25-20/h3-7,10,13-14,17,26H,8-9,11-12H2,1-2H3
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373768
PNG
((S)-3-chloro-4-((1-(2-fluoro-5-methylbenzyl)pyrrol...)
Show SMILES CN([C@H]1CCN(Cc2cc(C)ccc2F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1/C21H23ClFN5O2S2/c1-14-3-5-19(23)15(9-14)11-28-8-7-16(12-28)27(2)20-6-4-17(10-18(20)22)32(29,30)26-21-24-13-25-31-21/h3-6,9-10,13,16H,7-8,11-12H2,1-2H3,(H,24,25,26)/t16-/s2
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM374014
PNG
((R)-2-fluoro-5-methyl-4-(methyl(1-(1-phenylethyl)p...)
Show SMILES C[C@@H](N1CCC(CC1)N(C)c1cc(F)c(cc1C)S(=O)(=O)Nc1cscn1)c1ccccc1
Show InChI InChI=1/C24H29FN4O2S2/c1-17-13-23(33(30,31)27-24-15-32-16-26-24)21(25)14-22(17)28(3)20-9-11-29(12-10-20)18(2)19-7-5-4-6-8-19/h4-8,13-16,18,20,27H,9-12H2,1-3H3/t18-/s2
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373763
PNG
((S)-3-chloro-4-((1-(3-chlorobenzyl)pyrrolidin-3-yl...)
Show SMILES CN([C@H]1CCN(Cc2cccc(Cl)c2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1/C20H21Cl2N5O2S2/c1-26(16-7-8-27(12-16)11-14-3-2-4-15(21)9-14)19-6-5-17(10-18(19)22)31(28,29)25-20-23-13-24-30-20/h2-6,9-10,13,16H,7-8,11-12H2,1H3,(H,23,24,25)/t16-/s2
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373957
PNG
((S)-2,6-difluoro-3-methyl-4-(methyl(1-((6-(trifluo...)
Show SMILES CN([C@H]1CCN(Cc2cccc(n2)C(F)(F)F)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C22H22F5N5O2S2/c1-13-17(8-16(23)21(20(13)24)36(33,34)30-19-11-35-12-28-19)31(2)15-6-7-32(10-15)9-14-4-3-5-18(29-14)22(25,26)27/h3-5,8,11-12,15,30H,6-7,9-10H2,1-2H3/t15-/s2
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373807
PNG
(4-((trans-1-benzyl-4-methylpyrrolidin-3-yl)amino)-...)
Show SMILES C[C@H]1CN(Cc2ccccc2)CC1Nc1ccc(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1/C21H23ClN4O2S2/c1-15-12-26(13-16-5-3-2-4-6-16)14-20(15)24-19-8-7-17(11-18(19)22)30(27,28)25-21-23-9-10-29-21/h2-11,15,20,24H,12-14H2,1H3,(H,23,25)/t15-,20?/s2
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n/an/a 25n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373837
PNG
((S)-2,6-difluoro-3-methyl-4-(methyl(1-((6-methylpy...)
Show SMILES CN(C1CCN(Cc2cccc(C)n2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C22H25F2N5O2S2/c1-14-5-4-6-16(26-14)10-29-8-7-17(11-29)28(3)19-9-18(23)22(21(24)15(19)2)33(30,31)27-20-12-32-13-25-20/h4-6,9,12-13,17,27H,7-8,10-11H2,1-3H3
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM374010
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2-f...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(cc1C)S(=O)(=O)Nc1ccsn1
Show InChI InChI=1/C22H25FN4O2S2/c1-16-12-21(31(28,29)25-22-9-11-30-24-22)19(23)13-20(16)26(2)18-8-10-27(15-18)14-17-6-4-3-5-7-17/h3-7,9,11-13,18H,8,10,14-15H2,1-2H3,(H,24,25)/t18-/s2
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n/an/a 27n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373764
PNG
((S)-3-chloro-4-((1-(3-(difluoromethyl)benzyl)pyrro...)
Show SMILES CN([C@H]1CCN(Cc2cccc(c2)C(F)F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1/C21H22ClF2N5O2S2/c1-28(16-7-8-29(12-16)11-14-3-2-4-15(9-14)20(23)24)19-6-5-17(10-18(19)22)33(30,31)27-21-25-13-26-32-21/h2-6,9-10,13,16,20H,7-8,11-12H2,1H3,(H,25,26,27)/t16-/s2
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n/an/a 29n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373816
PNG
((S)-3-chloro-4-(methyl(1-(3-methylbenzyl)pyrrolidi...)
Show SMILES CN([C@H]1CCN(Cc2cccc(C)c2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H24ClN5O2S2/c1-15-4-3-5-16(10-15)12-27-9-8-17(13-27)26(2)20-7-6-18(11-19(20)22)31(28,29)25-21-23-14-24-30-21/h3-7,10-11,14,17H,8-9,12-13H2,1-2H3,(H,23,24,25)/t17-/m0/s1
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n/an/a 29n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373749
PNG
(4-(((1R,3s,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3...)
Show SMILES Clc1cc(ccc1O[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccccc1)S(=O)(=O)Nc1nccs1
Show InChI InChI=1/C23H24ClN3O3S2/c24-21-14-20(32(28,29)26-23-25-10-11-31-23)8-9-22(21)30-19-12-17-6-7-18(13-19)27(17)15-16-4-2-1-3-5-16/h1-5,8-11,14,17-19H,6-7,12-13,15H2,(H,25,26)/t17-,18+,19-
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n/an/a 30n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373961
PNG
(US10246453, Example 228 | rac-4-((1-benzyl-3-methy...)
Show SMILES Cc1c(F)c(c(F)cc1OC1(C)CCN(Cc2ccccc2)C1)S(=O)(=O)Nc1nccs1
Show InChI InChI=1/C22H23F2N3O3S2/c1-15-18(30-22(2)8-10-27(14-22)13-16-6-4-3-5-7-16)12-17(23)20(19(15)24)32(28,29)26-21-25-9-11-31-21/h3-7,9,11-12H,8,10,13-14H2,1-2H3,(H,25,26)
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n/an/a 31n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373788
PNG
((R)-3-chloro-4-((1-(1-phenylethyl)piperidin-4-yl)o...)
Show SMILES C[C@@H](N1CCC(CC1)Oc1ccc(cc1Cl)S(=O)(=O)Nc1nccs1)c1ccccc1
Show InChI InChI=1/C22H24ClN3O3S2/c1-16(17-5-3-2-4-6-17)26-12-9-18(10-13-26)29-21-8-7-19(15-20(21)23)31(27,28)25-22-24-11-14-30-22/h2-8,11,14-16,18H,9-10,12-13H2,1H3,(H,24,25)/t16-/s2
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n/an/a 32n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373839
PNG
(4-((1-benzylpiperidin-4-yl)oxy)-2,6-difluoro-3-met...)
Show SMILES Cc1c(F)c(c(F)cc1OC1CCN(Cc2ccccc2)CC1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H23F2N3O3S2/c1-15-19(30-17-7-9-27(10-8-17)12-16-5-3-2-4-6-16)11-18(23)22(21(15)24)32(28,29)26-20-13-31-14-25-20/h2-6,11,13-14,17,26H,7-10,12H2,1H3
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n/an/a 34n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373816
PNG
((S)-3-chloro-4-(methyl(1-(3-methylbenzyl)pyrrolidi...)
Show SMILES CN([C@H]1CCN(Cc2cccc(C)c2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H24ClN5O2S2/c1-15-4-3-5-16(10-15)12-27-9-8-17(13-27)26(2)20-7-6-18(11-19(20)22)31(28,29)25-21-23-14-24-30-21/h3-7,10-11,14,17H,8-9,12-13H2,1-2H3,(H,23,24,25)/t17-/m0/s1
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n/an/a 36n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373761
PNG
((S)-3-chloro-4-((1-(3-(difluoromethyl)benzyl)pyrro...)
Show SMILES CN([C@H]1CCN(Cc2cccc(c2)C(F)F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1/C22H23ClF2N4O2S2/c1-28(17-7-9-29(14-17)13-15-3-2-4-16(11-15)21(24)25)20-6-5-18(12-19(20)23)33(30,31)27-22-26-8-10-32-22/h2-6,8,10-12,17,21H,7,9,13-14H2,1H3,(H,26,27)/t17-/s2
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n/an/a 36n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM374016
PNG
((R)-2,6-difluoro-3-methyl-4-((1-(1-phenylethyl)pip...)
Show SMILES C[C@@H](N1CCC(CC1)Oc1cc(F)c(c(F)c1Cl)S(=O)(=O)Nc1cscn1)c1ccccc1
Show InChI InChI=1/C22H22ClF2N3O3S2/c1-14(15-5-3-2-4-6-15)28-9-7-16(8-10-28)31-18-11-17(24)22(21(25)20(18)23)33(29,30)27-19-12-32-13-26-19/h2-6,11-14,16,27H,7-10H2,1H3/t14-/s2
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n/an/a 37n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373767
PNG
((S)-3-chloro-4-((1-(2-fluoro-3-methylbenzyl)pyrrol...)
Show SMILES CN([C@H]1CCN(Cc2cccc(C)c2F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1/C21H23ClFN5O2S2/c1-14-4-3-5-15(20(14)23)11-28-9-8-16(12-28)27(2)19-7-6-17(10-18(19)22)32(29,30)26-21-24-13-25-31-21/h3-7,10,13,16H,8-9,11-12H2,1-2H3,(H,24,25,26)/t16-/s2
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n/an/a 39n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373821
PNG
((R)-5-chloro-2-fluoro-4-(1-(3-methylbenzyl)pyrroli...)
Show SMILES Cc1cccc(CN2CC[C@H](C2)Nc2cc(F)c(cc2Cl)S(=O)(=O)Nc2nccs2)c1
Show InChI InChI=1S/C21H22ClFN4O2S2/c1-14-3-2-4-15(9-14)12-27-7-5-16(13-27)25-19-11-18(23)20(10-17(19)22)31(28,29)26-21-24-6-8-30-21/h2-4,6,8-11,16,25H,5,7,12-13H2,1H3,(H,24,26)/t16-/m1/s1
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n/an/a 39n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373766
PNG
((S)-3-chloro-4-((1-(5-chloro-2-fluorobenzyl)pyrrol...)
Show SMILES CN([C@H]1CCN(Cc2cc(Cl)ccc2F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1/C20H20Cl2FN5O2S2/c1-27(15-6-7-28(11-15)10-13-8-14(21)2-4-18(13)23)19-5-3-16(9-17(19)22)32(29,30)26-20-24-12-25-31-20/h2-5,8-9,12,15H,6-7,10-11H2,1H3,(H,24,25,26)/t15-/s2
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n/an/a 41n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM374031
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cccc(F)n1
Show InChI InChI=1/C24H25F3N4O2S/c1-16-20(30(2)18-11-12-31(15-18)14-17-7-4-3-5-8-17)13-19(25)24(23(16)27)34(32,33)29-22-10-6-9-21(26)28-22/h3-10,13,18H,11-12,14-15H2,1-2H3,(H,28,29)/t18-/s2
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373968
PNG
((S)-2,6-difluoro-4-((1-(3-fluorobenzyl)pyrrolidin-...)
Show SMILES CN([C@H]1CCN(Cc2cccc(F)c2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C22H23F3N4O2S2/c1-14-19(9-18(24)22(21(14)25)33(30,31)27-20-12-32-13-26-20)28(2)17-6-7-29(11-17)10-15-4-3-5-16(23)8-15/h3-5,8-9,12-13,17,27H,6-7,10-11H2,1-2H3/t17-/s2
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n/an/a 47n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373765
PNG
((S)-3-chloro-4-((1-(3-chloro-2-fluorobenzyl)pyrrol...)
Show SMILES CN([C@H]1CCN(Cc2cccc(Cl)c2F)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1/C20H20Cl2FN5O2S2/c1-27(14-7-8-28(11-14)10-13-3-2-4-16(21)19(13)23)18-6-5-15(9-17(18)22)32(29,30)26-20-24-12-25-31-20/h2-6,9,12,14H,7-8,10-11H2,1H3,(H,24,25,26)/t14-/s2
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n/an/a 47n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373840
PNG
((S)-2-fluoro-4-((1-((2-isopropylthiazol-4-yl)methy...)
Show SMILES CC(C)c1nc(CN2CC[C@@H](C2)N(C)c2cc(F)c(cc2C)S(=O)(=O)Nc2cscn2)cs1
Show InChI InChI=1/C22H28FN5O2S3/c1-14(2)22-25-16(11-32-22)9-28-6-5-17(10-28)27(4)19-8-18(23)20(7-15(19)3)33(29,30)26-21-12-31-13-24-21/h7-8,11-14,17,26H,5-6,9-10H2,1-4H3/t17-/s2
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n/an/a 49n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373871
PNG
((S)-4-((1-((2-cyclopropylthiazol-4-yl)methyl)pyrro...)
Show SMILES CN([C@H]1CCN(Cc2csc(n2)C2CC2)C1)c1cc(F)c(cc1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H26FN5O2S3/c1-14-7-20(33(29,30)26-21-12-31-13-24-21)18(23)8-19(14)27(2)17-5-6-28(10-17)9-16-11-32-22(25-16)15-3-4-15/h7-8,11-13,15,17,26H,3-6,9-10H2,1-2H3/t17-/m0/s1
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373834
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2-f...)
Show SMILES CN(C1CCN(Cc2ccccc2)C1)c1cc(F)c(cc1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C22H25FN4O2S2/c1-16-10-21(31(28,29)25-22-14-30-15-24-22)19(23)11-20(16)26(2)18-8-9-27(13-18)12-17-6-4-3-5-7-17/h3-7,10-11,14-15,18,25H,8-9,12-13H2,1-2H3
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n/an/a 54n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373815
PNG
(3-chloro-4-(1-((6-methylpyridin-2-yl)methyl)piperi...)
Show SMILES Cc1cccc(CN2CCC(CC2)Oc2ccc(cc2Cl)S(=O)(=O)Nc2nccs2)n1
Show InChI InChI=1S/C21H23ClN4O3S2/c1-15-3-2-4-16(24-15)14-26-10-7-17(8-11-26)29-20-6-5-18(13-19(20)22)31(27,28)25-21-23-9-12-30-21/h2-6,9,12-13,17H,7-8,10-11,14H2,1H3,(H,23,25)
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n/an/a 56n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373851
PNG
((S)-2-fluoro-5-methyl-4-(methyl(1-((1-(2,2,2-trifl...)
Show SMILES CN([C@H]1CCN(Cc2ccn(CC(F)(F)F)n2)C1)c1cc(F)c(cc1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C21H24F4N6O2S2/c1-14-7-19(35(32,33)28-20-11-34-13-26-20)17(22)8-18(14)29(2)16-4-5-30(10-16)9-15-3-6-31(27-15)12-21(23,24)25/h3,6-8,11,13,16,28H,4-5,9-10,12H2,1-2H3/t16-/m0/s1
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n/an/a 58n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373762
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-3-c...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1ncns1
Show InChI InChI=1/C20H22ClN5O2S2/c1-25(16-9-10-26(13-16)12-15-5-3-2-4-6-15)19-8-7-17(11-18(19)21)30(27,28)24-20-22-14-23-29-20/h2-8,11,14,16H,9-10,12-13H2,1H3,(H,22,23,24)/t16-/s2
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373836
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Show SMILES CN(C1CCN(Cc2ccccc2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C22H24F2N4O2S2/c1-15-19(27(2)17-8-9-28(12-17)11-16-6-4-3-5-7-16)10-18(23)22(21(15)24)32(29,30)26-20-13-31-14-25-20/h3-7,10,13-14,17,26H,8-9,11-12H2,1-2H3
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n/an/a 61n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM374029
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Show SMILES CN([C@H]1CCN(Cc2cccc(C)n2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1ncns1
Show InChI InChI=1/C21H24F2N6O2S2/c1-13-5-4-6-15(26-13)10-29-8-7-16(11-29)28(3)18-9-17(22)20(19(23)14(18)2)33(30,31)27-21-24-12-25-32-21/h4-6,9,12,16H,7-8,10-11H2,1-3H3,(H,24,25,27)/t16-/s2
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n/an/a 62n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373970
PNG
((S)-4-((1-(2,3-difluorobenzyl)pyrrolidin-3-yl)(met...)
Show SMILES CN([C@H]1CCN(Cc2cccc(F)c2F)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C22H22F4N4O2S2/c1-13-18(8-17(24)22(20(13)25)34(31,32)28-19-11-33-12-27-19)29(2)15-6-7-30(10-15)9-14-4-3-5-16(23)21(14)26/h3-5,8,11-12,15,28H,6-7,9-10H2,1-2H3/t15-/s2
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n/an/a 64n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM374012
PNG
((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1ccsn1
Show InChI InChI=1/C22H24F2N4O2S2/c1-15-19(27(2)17-8-10-28(14-17)13-16-6-4-3-5-7-16)12-18(23)22(21(15)24)32(29,30)26-20-9-11-31-25-20/h3-7,9,11-12,17H,8,10,13-14H2,1-2H3,(H,25,26)/t17-/s2
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n/an/a 64n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM374000
PNG
((S)-3-chloro-2,6-difluoro-4-(methyl(1-((6-methylpy...)
Show SMILES CN([C@H]1CCN(Cc2cccc(C)n2)C1)c1cc(F)c(c(F)c1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C21H22ClF2N5O2S2/c1-13-4-3-5-14(26-13)9-29-7-6-15(10-29)28(2)17-8-16(23)21(20(24)19(17)22)33(30,31)27-18-11-32-12-25-18/h3-5,8,11-12,15,27H,6-7,9-10H2,1-2H3/t15-/s2
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n/an/a 66n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373969
PNG
((S)-2,6-difluoro-4-((1-(2-fluorobenzyl)pyrrolidin-...)
Show SMILES CN([C@H]1CCN(Cc2ccccc2F)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1
Show InChI InChI=1/C22H23F3N4O2S2/c1-14-19(9-18(24)22(21(14)25)33(30,31)27-20-12-32-13-26-20)28(2)16-7-8-29(11-16)10-15-5-3-4-6-17(15)23/h3-6,9,12-13,16,27H,7-8,10-11H2,1-2H3/t16-/s2
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n/an/a 67n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM374016
PNG
((R)-2,6-difluoro-3-methyl-4-((1-(1-phenylethyl)pip...)
Show SMILES C[C@@H](N1CCC(CC1)Oc1cc(F)c(c(F)c1Cl)S(=O)(=O)Nc1cscn1)c1ccccc1
Show InChI InChI=1/C22H22ClF2N3O3S2/c1-14(15-5-3-2-4-6-15)28-9-7-16(8-10-28)31-18-11-17(24)22(21(25)20(18)23)33(29,30)27-19-12-32-13-26-19/h2-6,11-14,16,27H,7-10H2,1H3/t14-/s2
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n/an/a 67n/an/an/an/an/an/a



Xenon Pharmaceuticals Inc.

US Patent


Assay Description
This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
Sodium channel alpha subunit


(Homo sapiens (Human))
BDBM373760
PNG
((S)-3-chloro-4-((1-(3-chlorobenzyl)pyrrolidin-3-yl...)
Show SMILES CN([C@H]1CCN(Cc2cccc(Cl)c2)C1)c1ccc(cc1Cl)S(=O)(=O)Nc1nccs1
Show InChI InChI=1/C21H22Cl2N4O2S2/c1-26(17-7-9-27(14-17)13-15-3-2-4-16(22)11-15)20-6-5-18(12-19(20)23)31(28,29)25-21-24-8-10-30-21/h2-6,8,10-12,17H,7,9,13-14H2,1H3,(H,24,25)/t17-/s2
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Xenon Pharmaceuticals Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...


US Patent US10246453 (2019)

More data for this
Ligand-Target Pair
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