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Patent code US10246456

Compile Data Set for Download or QSAR

Found 686 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374122
PNG
((S)-1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl...)
Show SMILES C[C@H](N)c1cccc(n1)-c1ccc2cnn(-c3cccc(C)n3)c2c1
Show InChI InChI=1S/C20H19N5/c1-13-5-3-8-20(23-13)25-19-11-15(9-10-16(19)12-22-25)18-7-4-6-17(24-18)14(2)21/h3-12,14H,21H2,1-2H3/t14-/m0/s1
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374140
PNG
(US10246456, Example 247)
Show SMILES Cc1cccc(n1)-n1ncc2ccc(cc12)-c1cccc(n1)C(N)CCO
Show InChI InChI=1/C21H21N5O/c1-14-4-2-7-21(24-14)26-20-12-15(8-9-16(20)13-23-26)18-5-3-6-19(25-18)17(22)10-11-27/h2-9,12-13,17,27H,10-11,22H2,1H3
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374157
PNG
(US10246456, Example 279)
Show SMILES COCc1cccc(n1)-n1ncc2ccc(cc12)-c1cccc(n1)C(C)N
Show InChI InChI=1/C21H21N5O/c1-14(22)18-6-4-7-19(25-18)15-9-10-16-12-23-26(20(16)11-15)21-8-3-5-17(24-21)13-27-2/h3-12,14H,13,22H2,1-2H3
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374182
PNG
(US10246456, Example 321)
Show SMILES CC(N)c1cccc(n1)-c1cc(F)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C20H18FN5O/c1-12(22)17-5-3-6-18(25-17)13-8-16(21)15-10-23-26(19(15)9-13)20-7-2-4-14(11-27)24-20/h2-10,12,27H,11,22H2,1H3
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374183
PNG
(US10246456, Example 322)
Show SMILES CC[C@@H](N)c1cccc(n1)-c1ccc2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C21H21N5O/c1-2-17(22)19-7-4-6-18(25-19)14-9-10-15-12-23-26(20(15)11-14)21-8-3-5-16(13-27)24-21/h3-12,17,27H,2,13,22H2,1H3/t17-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374185
PNG
(US10246456, Example 325)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(N2CCC(O)C2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C26H30N6O2/c1-2-5-21(27)23-8-4-7-22(30-23)17-12-24(31-11-10-19(34)15-31)20-14-28-32(25(20)13-17)26-9-3-6-18(16-33)29-26/h3-4,6-9,12-14,19,21,33-34H,2,5,10-11,15-16,27H2,1H3/t19?,21-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374199
PNG
(US10246456, Example 339)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(N2CCOCC2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C26H30N6O2/c1-2-5-21(27)23-8-4-7-22(30-23)18-14-24(31-10-12-34-13-11-31)20-16-28-32(25(20)15-18)26-9-3-6-19(17-33)29-26/h3-4,6-9,14-16,21,33H,2,5,10-13,17,27H2,1H3/t21-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374205
PNG
(US10246456, Example 345)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(N2CCC2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C25H28N6O/c1-2-6-20(26)22-9-4-8-21(29-22)17-13-23(30-11-5-12-30)19-15-27-31(24(19)14-17)25-10-3-7-18(16-32)28-25/h3-4,7-10,13-15,20,32H,2,5-6,11-12,16,26H2,1H3/t20-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374207
PNG
(US10246456, Example 347)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(N2CCCC(F)(F)C2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C27H30F2N6O/c1-2-6-21(30)23-9-4-8-22(33-23)18-13-24(34-12-5-11-27(28,29)17-34)20-15-31-35(25(20)14-18)26-10-3-7-19(16-36)32-26/h3-4,7-10,13-15,21,36H,2,5-6,11-12,16-17,30H2,1H3/t21-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374216
PNG
((S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(1-meth...)
Show SMILES C[C@H](N)c1cccc(n1)-c1cc(-c2ccn(C)n2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1S/C24H23N7O/c1-15(25)20-6-4-7-21(28-20)16-11-18(22-9-10-30(2)29-22)19-13-26-31(23(19)12-16)24-8-3-5-17(14-32)27-24/h3-13,15,32H,14,25H2,1-2H3/t15-/m0/s1
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374227
PNG
(US10246456, Example 368)
Show SMILES C[C@H](N)c1cccc(n1)-c1cc(-c2csc(C)n2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C24H22N6OS/c1-14(25)20-6-4-7-21(29-20)16-9-18(22-13-32-15(2)27-22)19-11-26-30(23(19)10-16)24-8-3-5-17(12-31)28-24/h3-11,13-14,31H,12,25H2,1-2H3/t14-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374231
PNG
(US10246456, Example 372)
Show SMILES C[C@H](N)c1cccc(n1)-c1cc(-c2ncc(C)s2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C24H22N6OS/c1-14-11-26-24(32-14)18-9-16(21-7-4-6-20(29-21)15(2)25)10-22-19(18)12-27-30(22)23-8-3-5-17(13-31)28-23/h3-12,15,31H,13,25H2,1-2H3/t15-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374258
PNG
((S)-(4-(6-(6-(1-aminobutyl)pyridin-2-yl)-1H-indazo...)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1ccc2cnn(-c3ccnc(CO)n3)c2c1
Show InChI InChI=1S/C21H22N6O/c1-2-4-16(22)18-6-3-5-17(25-18)14-7-8-15-12-24-27(19(15)11-14)21-9-10-23-20(13-28)26-21/h3,5-12,16,28H,2,4,13,22H2,1H3/t16-/m0/s1
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374263
PNG
((S)-(6-(6-(6-(1-aminobutyl)pyrazin-2-yl)-1H-indazo...)
Show SMILES Brc1cncc(Br)n1
Show InChI InChI=1S/C4H2Br2N2/c5-3-1-7-2-4(6)8-3/h1-2H
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374268
PNG
((S)-(6-(6-(4-(1-aminobutyl)pyrimidin-2-yl)-1H-inda...)
Show SMILES CON(C)C(=O)c1ccnc(Cl)n1
Show InChI InChI=1S/C7H8ClN3O2/c1-11(13-2)6(12)5-3-4-9-7(8)10-5/h3-4H,1-2H3
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374289
PNG
((S)-(6-(6-(6-(1-amino-3,3-difluorobutyl)pyridin-2-...)
Show SMILES CC(F)(F)C[C@H](N)c1cccc(n1)-c1ccc2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1S/C22H21F2N5O/c1-22(23,24)11-17(25)19-6-3-5-18(28-19)14-8-9-15-12-26-29(20(15)10-14)21-7-2-4-16(13-30)27-21/h2-10,12,17,30H,11,13,25H2,1H3/t17-/m0/s1
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374294
PNG
((6-(6-(6-((1R,2S)-1-amino-2-fluorobutyl)pyridin-2-...)
Show SMILES CCC(OC)C(=O)c1cccc(Br)n1
Show InChI InChI=1/C10H12BrNO2/c1-3-8(14-2)10(13)7-5-4-6-9(11)12-7/h4-6,8H,3H2,1-2H3
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374308
PNG
((S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(3-meth...)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(OCCCOC)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1S/C26H31N5O3/c1-3-7-21(27)23-10-5-9-22(30-23)18-14-24-20(25(15-18)34-13-6-12-33-2)16-28-31(24)26-11-4-8-19(17-32)29-26/h4-5,8-11,14-16,21,32H,3,6-7,12-13,17,27H2,1-2H3/t21-/m0/s1
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374318
PNG
((6-(6-(6-(1-aminocyclobutyl)pyridin-2-yl)-4-(2-met...)
Show SMILES COCCOc1cc(cc2n(ncc12)-c1cncc(CO)n1)-c1cccc(n1)C1(N)CCC1
Show InChI InChI=1S/C24H26N6O3/c1-32-8-9-33-21-11-16(19-4-2-5-22(29-19)24(25)6-3-7-24)10-20-18(21)13-27-30(20)23-14-26-12-17(15-31)28-23/h2,4-5,10-14,31H,3,6-9,15,25H2,1H3
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374334
PNG
(US10246456, Example 486)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1ccc2cnn(-c3nccc(n3)C(F)F)c2c1
Show InChI InChI=1/C21H20F2N6/c1-2-4-15(24)17-6-3-5-16(27-17)13-7-8-14-12-26-29(19(14)11-13)21-25-10-9-18(28-21)20(22)23/h3,5-12,15,20H,2,4,24H2,1H3/t15-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374335
PNG
(US10246456, Example 487)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(CF)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C23H24FN5O/c1-2-5-19(25)21-8-4-7-20(28-21)15-10-16(12-24)18-13-26-29(22(18)11-15)23-9-3-6-17(14-30)27-23/h3-4,6-11,13,19,30H,2,5,12,14,25H2,1H3/t19-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374336
PNG
(US10246456, Example 488)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(C2=CCN(CC2)C(C)=O)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C29H32N6O2/c1-3-6-25(30)27-9-5-8-26(33-27)21-15-23(20-11-13-34(14-12-20)19(2)37)24-17-31-35(28(24)16-21)29-10-4-7-22(18-36)32-29/h4-5,7-11,15-17,25,36H,3,6,12-14,18,30H2,1-2H3/t25-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374338
PNG
(US10246456, Example 490)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(Cl)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C22H22ClN5O/c1-2-5-18(24)20-8-4-7-19(27-20)14-10-17(23)16-12-25-28(21(16)11-14)22-9-3-6-15(13-29)26-22/h3-4,6-12,18,29H,2,5,13,24H2,1H3/t18-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374343
PNG
(US10246456, Example 495)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(COC)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C24H27N5O2/c1-3-6-20(25)22-9-5-8-21(28-22)16-11-17(15-31-2)19-13-26-29(23(19)12-16)24-10-4-7-18(14-30)27-24/h4-5,7-13,20,30H,3,6,14-15,25H2,1-2H3/t20-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374348
PNG
(US10246456, Example 500)
Show SMILES CCOc1cc(cc2n(ncc12)-c1cncc(CO)n1)-c1cccc(n1)[C@@H](N)CC
Show InChI InChI=1/C22H24N6O2/c1-3-17(23)19-7-5-6-18(27-19)14-8-20-16(21(9-14)30-4-2)11-25-28(20)22-12-24-10-15(13-29)26-22/h5-12,17,29H,3-4,13,23H2,1-2H3/t17-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374368
PNG
(US10246456, Example 521)
Show SMILES CC(C)C[C@H](N)c1cccc(n1)-c1ccc2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C23H25N5O/c1-15(2)11-19(24)21-7-4-6-20(27-21)16-9-10-17-13-25-28(22(17)12-16)23-8-3-5-18(14-29)26-23/h3-10,12-13,15,19,29H,11,14,24H2,1-2H3/t19-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374376
PNG
(US10246456, Example 529)
Show SMILES C[C@@H](N)c1cccc(n1)-c1ccc2cnn(-c3cccc(n3)C(F)F)c2c1
Show InChI InChI=1/C20H17F2N5/c1-12(23)15-4-2-5-16(25-15)13-8-9-14-11-24-27(18(14)10-13)19-7-3-6-17(26-19)20(21)22/h2-12,20H,23H2,1H3/t12-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374375
PNG
(US10246456, Example 528)
Show SMILES C[C@H](N)c1cccc(n1)-c1cc(C2=NC(C)CO2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C24H24N6O2/c1-14-13-32-24(27-14)18-9-16(21-7-4-6-20(29-21)15(2)25)10-22-19(18)11-26-30(22)23-8-3-5-17(12-31)28-23/h3-11,14-15,31H,12-13,25H2,1-2H3/t14?,15-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374378
PNG
(US10246456, Example 532)
Show SMILES CS(=O)(=O)CC(N)c1cccc(n1)-c1ccc2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C21H21N5O3S/c1-30(28,29)13-17(22)19-6-3-5-18(25-19)14-8-9-15-11-23-26(20(15)10-14)21-7-2-4-16(12-27)24-21/h2-11,17,27H,12-13,22H2,1H3
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374384
PNG
(US10246456, Example 539)
Show SMILES CC[C@H](N)c1cccc(n1)-c1ccc2cnn(-c3cccc(n3)C(F)F)c2c1
Show InChI InChI=1/C21H19F2N5/c1-2-15(24)17-6-3-5-16(26-17)13-9-10-14-12-25-28(19(14)11-13)20-8-4-7-18(27-20)21(22)23/h3-12,15,21H,2,24H2,1H3/t15-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374388
PNG
(US10246456, Example 545)
Show SMILES C[C@H](N)c1cccc(n1)-c1ccc2cnn(-c3ccc(F)c(CO)n3)c2c1
Show InChI InChI=1/C20H18FN5O/c1-12(22)16-3-2-4-17(24-16)13-5-6-14-10-23-26(19(14)9-13)20-8-7-15(21)18(11-27)25-20/h2-10,12,27H,11,22H2,1H3/t12-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374411
PNG
(US10246456, Example 594)
Show SMILES COCCOc1cc(cc2n(ncc12)-c1cccc(CO)n1)-c1cccc(n1)[C@@H](N)CF
Show InChI InChI=1/C23H24FN5O3/c1-31-8-9-32-22-11-15(19-5-3-6-20(28-19)18(25)12-24)10-21-17(22)13-26-29(21)23-7-2-4-16(14-30)27-23/h2-7,10-11,13,18,30H,8-9,12,14,25H2,1H3/t18-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374414
PNG
(US10246456, Example 597)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(C2CCOC2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C26H29N5O2/c1-2-5-22(27)24-8-4-7-23(30-24)18-12-20(17-10-11-33-16-17)21-14-28-31(25(21)13-18)26-9-3-6-19(15-32)29-26/h3-4,6-9,12-14,17,22,32H,2,5,10-11,15-16,27H2,1H3/t17?,22-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374263
PNG
((S)-(6-(6-(6-(1-aminobutyl)pyrazin-2-yl)-1H-indazo...)
Show SMILES Brc1cncc(Br)n1
Show InChI InChI=1S/C4H2Br2N2/c5-3-1-7-2-4(6)8-3/h1-2H
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374266
PNG
((S)-4-amino-4-(6-(4-ethoxy-1-(6-(hydroxymethyl)pyr...)
Show SMILES CCOc1cc(cc2n(ncc12)-c1cccc(CO)n1)-c1cccc(n1)[C@@H](N)CCCO
Show InChI InChI=1S/C24H27N5O3/c1-2-32-23-13-16(20-8-4-9-21(28-20)19(25)7-5-11-30)12-22-18(23)14-26-29(22)24-10-3-6-17(15-31)27-24/h3-4,6,8-10,12-14,19,30-31H,2,5,7,11,15,25H2,1H3/t19-/m0/s1
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374281
PNG
((S)-(6-(6-(6-(1-amino-4,4,4-trifluorobutyl)pyridin...)
Show SMILES N[C@@H](CCC(F)(F)F)c1cccc(n1)-c1ccc2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1S/C22H20F3N5O/c23-22(24,25)10-9-17(26)19-5-2-4-18(29-19)14-7-8-15-12-27-30(20(15)11-14)21-6-1-3-16(13-31)28-21/h1-8,11-12,17,31H,9-10,13,26H2/t17-/m0/s1
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374284
PNG
((4R)-4-amino-3-fluoro-4-(6-(1-(6-(hydroxymethyl)py...)
Show SMILES COCCOc1cc(cc2n(ncc12)-c1cccc(CO)n1)-c1cccc(n1)[C@@H](N)C(F)CCO
Show InChI InChI=1S/C25H28FN5O4/c1-34-10-11-35-23-13-16(20-5-3-6-21(30-20)25(27)19(26)8-9-32)12-22-18(23)14-28-31(22)24-7-2-4-17(15-33)29-24/h2-7,12-14,19,25,32-33H,8-11,15,27H2,1H3/t19?,25-/m0/s1
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374300
PNG
((6-(6-(6-(1-amino-2-(3-methyloxetan-3-yl)ethyl)pyr...)
Show SMILES CC1(CC(N)c2cccc(n2)-c2ccc3cnn(-c4cccc(CO)n4)c3c2)COC1
Show InChI InChI=1/C24H25N5O2/c1-24(14-31-15-24)11-19(25)21-6-3-5-20(28-21)16-8-9-17-12-26-29(22(17)10-16)23-7-2-4-18(13-30)27-23/h2-10,12,19,30H,11,13-15,25H2,1H3
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374317
PNG
((6-(6-(6-(1-aminocyclobutyl)pyridin-2-yl)-4-(2-met...)
Show SMILES COCCOc1cc(cc2n(ncc12)-c1cccc(CO)n1)-c1cccc(n1)C1(N)CCC1
Show InChI InChI=1S/C25H27N5O3/c1-32-11-12-33-22-14-17(20-6-3-7-23(29-20)25(26)9-4-10-25)13-21-19(22)15-27-30(21)24-8-2-5-18(16-31)28-24/h2-3,5-8,13-15,31H,4,9-12,16,26H2,1H3
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374328
PNG
((S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(2-meth...)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(OCCOC)c2cnn(-c3cncc(CO)n3)c2c1
Show InChI InChI=1S/C24H28N6O3/c1-3-5-19(25)21-7-4-6-20(29-21)16-10-22-18(23(11-16)33-9-8-32-2)13-27-30(22)24-14-26-12-17(15-31)28-24/h4,6-7,10-14,19,31H,3,5,8-9,15,25H2,1-2H3/t19-/m0/s1
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374356
PNG
(US10246456, Example 509)
Show SMILES COCCC[C@H](N)c1cccc(n1)-c1cc(OC)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C24H27N5O3/c1-31-11-5-7-19(25)21-9-4-8-20(28-21)16-12-22-18(23(13-16)32-2)14-26-29(22)24-10-3-6-17(15-30)27-24/h3-4,6,8-10,12-14,19,30H,5,7,11,15,25H2,1-2H3/t19-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374357
PNG
(US10246456, Example 510)
Show SMILES CCOc1cc(cc2n(ncc12)-c1cccc(CO)n1)-c1cccc(n1)[C@@H](N)CCC(F)(F)F
Show InChI InChI=1/C24H24F3N5O2/c1-2-34-22-12-15(19-6-4-7-20(31-19)18(28)9-10-24(25,26)27)11-21-17(22)13-29-32(21)23-8-3-5-16(14-33)30-23/h3-8,11-13,18,33H,2,9-10,14,28H2,1H3/t18-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374369
PNG
(US10246456, Example 522)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(OCCC2CC2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C27H31N5O2/c1-2-5-22(28)24-8-4-7-23(31-24)19-14-25-21(26(15-19)34-13-12-18-10-11-18)16-29-32(25)27-9-3-6-20(17-33)30-27/h3-4,6-9,14-16,18,22,33H,2,5,10-13,17,28H2,1H3/t22-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374381
PNG
(US10246456, Example 536)
Show SMILES CC(N)c1cccc(n1)-c1cc(-c2cnco2)c2cnn(-c3cccc(C)n3)c2c1
Show InChI InChI=1/C23H20N6O/c1-14-5-3-8-23(27-14)29-21-10-16(20-7-4-6-19(28-20)15(2)24)9-17(18(21)11-26-29)22-12-25-13-30-22/h3-13,15H,24H2,1-2H3
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374386
PNG
(US10246456, Example 543)
Show SMILES COCC(N)c1cccc(n1)-c1ccc2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C21H21N5O2/c1-28-13-17(22)19-6-3-5-18(25-19)14-8-9-15-11-23-26(20(15)10-14)21-7-2-4-16(12-27)24-21/h2-11,17,27H,12-13,22H2,1H3
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374407
PNG
(US10246456, Example 589)
Show SMILES N[C@@H](CF)c1cccc(n1)-c1ccc2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C20H18FN5O/c21-10-16(22)18-5-2-4-17(25-18)13-7-8-14-11-23-26(19(14)9-13)20-6-1-3-15(12-27)24-20/h1-9,11,16,27H,10,12,22H2/t16-/s2
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374068
PNG
(6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)picolin...)
Show SMILES NC(=O)c1cccc(n1)-n1ncc2ccc(cc12)-c1cncc(N)c1
Show InChI InChI=1S/C18H14N6O/c19-14-6-13(8-21-10-14)11-4-5-12-9-22-24(16(12)7-11)17-3-1-2-15(23-17)18(20)25/h1-10H,19H2,(H2,20,25)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374073
PNG
(3-(3-(6-methylpyridin-2-yl)imidazo[1,5-a]pyridin-6...)
Show SMILES Cc1cccc(n1)-c1ncc2ccc(cn12)-c1cccc(N)c1
Show InChI InChI=1S/C19H16N4/c1-13-4-2-7-18(22-13)19-21-11-17-9-8-15(12-23(17)19)14-5-3-6-16(20)10-14/h2-12H,20H2,1H3
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374074
PNG
(6-(6-(6-(aminomethyl)pyridin-2-yl)-1H-indazol-1-yl...)
Show SMILES NCc1cccc(n1)-c1ccc2cnn(-c3cccc(n3)C(N)=O)c2c1
Show InChI InChI=1S/C19H16N6O/c20-10-14-3-1-4-15(23-14)12-7-8-13-11-22-25(17(13)9-12)18-6-2-5-16(24-18)19(21)26/h1-9,11H,10,20H2,(H2,21,26)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374079
PNG
(6-(5-aminopyridin-3-yl)-1-(6-(trifluoromethyl)pyri...)
Show SMILES NC(=O)c1cc(cc2n(ncc12)-c1cccc(n1)C(F)(F)F)-c1cncc(N)c1
Show InChI InChI=1S/C19H13F3N6O/c20-19(21,22)16-2-1-3-17(27-16)28-15-6-10(11-4-12(23)8-25-7-11)5-13(18(24)29)14(15)9-26-28/h1-9H,23H2,(H2,24,29)
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BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%