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Patent code US10246466

Compile Data Set for Download or QSAR
Found 54 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM374714
PNG
(12-chloro-11-fluoro-14-methyl-6,7,13,14- tetrahydr...)
Show SMILES CN1Cc2c(Cl)c(F)ccc2OCCNC(=O)c2cnn3ccc1nc23
Show InChI InChI=1S/C17H15ClFN5O2/c1-23-9-11-13(3-2-12(19)15(11)18)26-7-5-20-17(25)10-8-21-24-6-4-14(23)22-16(10)24/h2-4,6,8H,5,7,9H2,1H3,(H,20,25)
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US Patent
n/an/an/a 180n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM374724
PNG
(12-chloro-11-fluoro-13-methyl-6,7,13,14- tetrahydr...)
Show SMILES CC1Nc2ccn3ncc(C(=O)NCCOc4ccc(F)c(Cl)c14)c3n2
Show InChI InChI=1/C17H15ClFN5O2/c1-9-14-12(3-2-11(19)15(14)18)26-7-5-20-17(25)10-8-21-24-6-4-13(22-9)23-16(10)24/h2-4,6,8-9H,5,7H2,1H3,(H,20,25)(H,22,23)
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n/an/an/a 270n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM374722
PNG
(11-fluoro-13-methyl-6,7,13,14-tetrahydro-1,15- eth...)
Show SMILES CC1Nc2ccn3ncc(C(=O)NCCOc4ccc(F)cc14)c3n2
Show InChI InChI=1/C17H16FN5O2/c1-10-12-8-11(18)2-3-14(12)25-7-5-19-17(24)13-9-20-23-6-4-15(21-10)22-16(13)23/h2-4,6,8-10H,5,7H2,1H3,(H,19,24)(H,21,22)
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n/an/an/a 0.150n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM374723
PNG
((13R)-11-fluoro-13-methyl-6,7,13,14- tetrahydro-1,...)
Show SMILES C[C@H]1Nc2ccn3ncc(C(=O)NCCOc4ccc(F)cc14)c3n2
Show InChI InChI=1/C17H16FN5O2/c1-10-12-8-11(18)2-3-14(12)25-7-5-19-17(24)13-9-20-23-6-4-15(21-10)22-16(13)23/h2-4,6,8-10H,5,7H2,1H3,(H,19,24)(H,21,22)/t10-/s2
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n/an/an/a 0.0510n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM374725
PNG
(12-fluoro-15-methyl-5,6,7,8,14,15-hexahydro-4H- 1,...)
Show SMILES CN1Cc2cc(F)ccc2OCCCNC(=O)c2cnn3ccc1nc23
Show InChI InChI=1S/C18H18FN5O2/c1-23-11-12-9-13(19)3-4-15(12)26-8-2-6-20-18(25)14-10-21-24-7-5-16(23)22-17(14)24/h3-5,7,9-10H,2,6,8,11H2,1H3,(H,20,25)
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n/an/an/a 0.0150n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM374725
PNG
(12-fluoro-15-methyl-5,6,7,8,14,15-hexahydro-4H- 1,...)
Show SMILES CN1Cc2cc(F)ccc2OCCCNC(=O)c2cnn3ccc1nc23
Show InChI InChI=1S/C18H18FN5O2/c1-23-11-12-9-13(19)3-4-15(12)26-8-2-6-20-18(25)14-10-21-24-7-5-16(23)22-17(14)24/h3-5,7,9-10H,2,6,8,11H2,1H3,(H,20,25)
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n/an/an/a 6.5n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM374716
PNG
(10-fluoro-8-methyl-15,16-dihydro-8H-3,6- ethenoimi...)
Show SMILES CC1Oc2ccc3ncc(C(=O)NCCOc4ccc(F)cc14)n3n2
Show InChI InChI=1/C17H15FN4O3/c1-10-12-8-11(18)2-3-14(12)24-7-6-19-17(23)13-9-20-15-4-5-16(25-10)21-22(13)15/h2-5,8-10H,6-7H2,1H3,(H,19,23)
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n/an/an/a 6n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM374722
PNG
(11-fluoro-13-methyl-6,7,13,14-tetrahydro-1,15- eth...)
Show SMILES CC1Nc2ccn3ncc(C(=O)NCCOc4ccc(F)cc14)c3n2
Show InChI InChI=1/C17H16FN5O2/c1-10-12-8-11(18)2-3-14(12)25-7-5-19-17(24)13-9-20-23-6-4-15(21-10)22-16(13)23/h2-4,6,8-10H,5,7H2,1H3,(H,19,24)(H,21,22)
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n/an/an/a 0.0650n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM374727
PNG
((7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14- tetrah...)
Show SMILES C[C@H]1CNC(=O)c2cnn3ccc(N[C@H](C)c4cc(F)ccc4O1)nc23
Show InChI InChI=1/C18H18FN5O2/c1-10-8-20-18(25)14-9-21-24-6-5-16(23-17(14)24)22-11(2)13-7-12(19)3-4-15(13)26-10/h3-7,9-11H,8H2,1-2H3,(H,20,25)(H,22,23)/t10-,11+/s2
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n/an/an/a 0.0820n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM374712
PNG
(12-chloro-11-fluoro-13-methyl-6,7-dihydro- 13H-1,1...)
Show SMILES CC1Oc2ccn3ncc(C(=O)NCCOc4ccc(F)c(Cl)c14)c3n2
Show InChI InChI=1/C17H14ClFN4O3/c1-9-14-12(3-2-11(19)15(14)18)25-7-5-20-17(24)10-8-21-23-6-4-13(26-9)22-16(10)23/h2-4,6,8-9H,5,7H2,1H3,(H,20,24)
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n/an/an/a 1.90E+3n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS


()
BDBM374712
PNG
(12-chloro-11-fluoro-13-methyl-6,7-dihydro- 13H-1,1...)
Show SMILES CC1Oc2ccn3ncc(C(=O)NCCOc4ccc(F)c(Cl)c14)c3n2
Show InChI InChI=1/C17H14ClFN4O3/c1-9-14-12(3-2-11(19)15(14)18)25-7-5-20-17(24)10-8-21-23-6-4-13(26-9)22-16(10)23/h2-4,6,8-9H,5,7H2,1H3,(H,20,24)
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UniChem
US Patent
n/an/an/a 1.90E+3n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM374713
PNG
(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Show SMILES CN1Cc2cc(F)ccc2OCCNC(=O)c2cnn3ccc1nc23
Show InChI InChI=1S/C17H16FN5O2/c1-22-10-11-8-12(18)2-3-14(11)25-7-5-19-17(24)13-9-20-23-6-4-15(22)21-16(13)23/h2-4,6,8-9H,5,7,10H2,1H3,(H,19,24)
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n/an/an/a>1.00E+3n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM374713
PNG
(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Show SMILES CN1Cc2cc(F)ccc2OCCNC(=O)c2cnn3ccc1nc23
Show InChI InChI=1S/C17H16FN5O2/c1-22-10-11-8-12(18)2-3-14(11)25-7-5-19-17(24)13-9-20-23-6-4-15(22)21-16(13)23/h2-4,6,8-9H,5,7,10H2,1H3,(H,19,24)
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n/an/an/a 4.80n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM374713
PNG
(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Show SMILES CN1Cc2cc(F)ccc2OCCNC(=O)c2cnn3ccc1nc23
Show InChI InChI=1S/C17H16FN5O2/c1-22-10-11-8-12(18)2-3-14(11)25-7-5-19-17(24)13-9-20-23-6-4-15(22)21-16(13)23/h2-4,6,8-9H,5,7,10H2,1H3,(H,19,24)
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n/an/an/a 80n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM374714
PNG
(12-chloro-11-fluoro-14-methyl-6,7,13,14- tetrahydr...)
Show SMILES CN1Cc2c(Cl)c(F)ccc2OCCNC(=O)c2cnn3ccc1nc23
Show InChI InChI=1S/C17H15ClFN5O2/c1-23-9-11-13(3-2-12(19)15(11)18)26-7-5-20-17(25)10-8-21-24-6-4-14(23)22-16(10)24/h2-4,6,8H,5,7,9H2,1H3,(H,20,25)
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n/an/an/a 0.230n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM374714
PNG
(12-chloro-11-fluoro-14-methyl-6,7,13,14- tetrahydr...)
Show SMILES CN1Cc2c(Cl)c(F)ccc2OCCNC(=O)c2cnn3ccc1nc23
Show InChI InChI=1S/C17H15ClFN5O2/c1-23-9-11-13(3-2-12(19)15(11)18)26-7-5-20-17(25)10-8-21-24-6-4-14(23)22-16(10)24/h2-4,6,8H,5,7,9H2,1H3,(H,20,25)
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n/an/an/a 27n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS


()
BDBM374714
PNG
(12-chloro-11-fluoro-14-methyl-6,7,13,14- tetrahydr...)
Show SMILES CN1Cc2c(Cl)c(F)ccc2OCCNC(=O)c2cnn3ccc1nc23
Show InChI InChI=1S/C17H15ClFN5O2/c1-23-9-11-13(3-2-12(19)15(11)18)26-7-5-20-17(25)10-8-21-24-6-4-14(23)22-16(10)24/h2-4,6,8H,5,7,9H2,1H3,(H,20,25)
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n/an/an/a 4.70n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM374716
PNG
(10-fluoro-8-methyl-15,16-dihydro-8H-3,6- ethenoimi...)
Show SMILES CC1Oc2ccc3ncc(C(=O)NCCOc4ccc(F)cc14)n3n2
Show InChI InChI=1/C17H15FN4O3/c1-10-12-8-11(18)2-3-14(12)24-7-6-19-17(23)13-9-20-15-4-5-16(25-10)21-22(13)15/h2-5,8-10H,6-7H2,1H3,(H,19,23)
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n/an/an/a 2.60n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM374717
PNG
(10-fluoro-7-methyl-7,8,15,16-tetrahydro-3,6- ethen...)
Show SMILES CN1Cc2cc(F)ccc2OCCNC(=O)c2cnc3ccc1nn23
Show InChI InChI=1S/C17H16FN5O2/c1-22-10-11-8-12(18)2-3-14(11)25-7-6-19-17(24)13-9-20-15-4-5-16(22)21-23(13)15/h2-5,8-9H,6-7,10H2,1H3,(H,19,24)
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n/an/an/a 0.0880n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM374726
PNG
((7R,13R)-11-fluoro-7,13-dimethyl-6,7,13,14- tetrah...)
Show SMILES C[C@@H]1CNC(=O)c2cnn3ccc(N[C@H](C)c4cc(F)ccc4O1)nc23
Show InChI InChI=1/C18H18FN5O2/c1-10-8-20-18(25)14-9-21-24-6-5-16(23-17(14)24)22-11(2)13-7-12(19)3-4-15(13)26-10/h3-7,9-11H,8H2,1-2H3,(H,20,25)(H,22,23)/t10-,11-/s2
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n/an/an/a 0.120n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
Neurotrophic tyrosine kinase receptor


(Homo sapiens (Human))
BDBM374713
PNG
(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Show SMILES CN1Cc2cc(F)ccc2OCCNC(=O)c2cnn3ccc1nc23
Show InChI InChI=1S/C17H16FN5O2/c1-22-10-11-8-12(18)2-3-14(11)25-7-5-19-17(24)13-9-20-23-6-4-15(22)21-16(13)23/h2-4,6,8-9H,5,7,10H2,1H3,(H,19,24)
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n/an/an/a 0.300n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS


()
BDBM374715
PNG
(11-fluoro-3,14-dimethyl-6,7,13,14-tetrahydro-1,15-...)
Show SMILES CN1Cc2cc(F)ccc2OCCNC(=O)c2c(C)nn3ccc1nc23
Show InChI InChI=1S/C18H18FN5O2/c1-11-16-17-21-15(5-7-24(17)22-11)23(2)10-12-9-13(19)3-4-14(12)26-8-6-20-18(16)25/h3-5,7,9H,6,8,10H2,1-2H3,(H,20,25)
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n/an/an/a 410n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM374718
PNG
(14-ethyl-11-fluoro-6,7,13,14-tetrahydro-1,15- ethe...)
Show SMILES CCN1Cc2cc(F)ccc2OCCNC(=O)c2cnn3ccc1nc23
Show InChI InChI=1S/C18H18FN5O2/c1-2-23-11-12-9-13(19)3-4-15(12)26-8-6-20-18(25)14-10-21-24-7-5-16(23)22-17(14)24/h3-5,7,9-10H,2,6,8,11H2,1H3,(H,20,25)
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n/an/an/a 3.70n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM374721
PNG
(11-fluoro-6,7,13,14-tetrahydro-1,15- ethenopyrazol...)
Show SMILES Fc1ccc2OCCNC(=O)c3cnn4ccc(NCc2c1)nc34
Show InChI InChI=1S/C16H14FN5O2/c17-11-1-2-13-10(7-11)8-19-14-3-5-22-15(21-14)12(9-20-22)16(23)18-4-6-24-13/h1-3,5,7,9H,4,6,8H2,(H,18,23)(H,19,21)
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n/an/an/a 0.200n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM374721
PNG
(11-fluoro-6,7,13,14-tetrahydro-1,15- ethenopyrazol...)
Show SMILES Fc1ccc2OCCNC(=O)c3cnn4ccc(NCc2c1)nc34
Show InChI InChI=1S/C16H14FN5O2/c17-11-1-2-13-10(7-11)8-19-14-3-5-22-15(21-14)12(9-20-22)16(23)18-4-6-24-13/h1-3,5,7,9H,4,6,8H2,(H,18,23)(H,19,21)
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n/an/an/a 0.570n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM374722
PNG
(11-fluoro-13-methyl-6,7,13,14-tetrahydro-1,15- eth...)
Show SMILES CC1Nc2ccn3ncc(C(=O)NCCOc4ccc(F)cc14)c3n2
Show InChI InChI=1/C17H16FN5O2/c1-10-12-8-11(18)2-3-14(12)25-7-5-19-17(24)13-9-20-23-6-4-15(21-10)22-16(13)23/h2-4,6,8-10H,5,7H2,1H3,(H,19,24)(H,21,22)
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n/an/an/a 65n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM374723
PNG
((13R)-11-fluoro-13-methyl-6,7,13,14- tetrahydro-1,...)
Show SMILES C[C@H]1Nc2ccn3ncc(C(=O)NCCOc4ccc(F)cc14)c3n2
Show InChI InChI=1/C17H16FN5O2/c1-10-12-8-11(18)2-3-14(12)25-7-5-19-17(24)13-9-20-23-6-4-15(21-10)22-16(13)23/h2-4,6,8-10H,5,7H2,1H3,(H,19,24)(H,21,22)/t10-/s2
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n/an/an/a 0.0480n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM374724
PNG
(12-chloro-11-fluoro-13-methyl-6,7,13,14- tetrahydr...)
Show SMILES CC1Nc2ccn3ncc(C(=O)NCCOc4ccc(F)c(Cl)c14)c3n2
Show InChI InChI=1/C17H15ClFN5O2/c1-9-14-12(3-2-11(19)15(14)18)26-7-5-20-17(25)10-8-21-24-6-4-13(22-9)23-16(10)24/h2-4,6,8-9H,5,7H2,1H3,(H,20,25)(H,22,23)
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n/an/an/a 6.5n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS


()
BDBM374724
PNG
(12-chloro-11-fluoro-13-methyl-6,7,13,14- tetrahydr...)
Show SMILES CC1Nc2ccn3ncc(C(=O)NCCOc4ccc(F)c(Cl)c14)c3n2
Show InChI InChI=1/C17H15ClFN5O2/c1-9-14-12(3-2-11(19)15(14)18)26-7-5-20-17(25)10-8-21-24-6-4-13(22-9)23-16(10)24/h2-4,6,8-9H,5,7H2,1H3,(H,20,25)(H,22,23)
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TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM374719
PNG
(11-fluoro-14-(propan-2-yl)-6,7,13,14-tetrahydro- 1...)
Show SMILES CC(C)N1Cc2cc(F)ccc2OCCNC(=O)c2cnn3ccc1nc23
Show InChI InChI=1S/C19H20FN5O2/c1-12(2)24-11-13-9-14(20)3-4-16(13)27-8-6-21-19(26)15-10-22-25-7-5-17(24)23-18(15)25/h3-5,7,9-10,12H,6,8,11H2,1-2H3,(H,21,26)
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n/an/an/a 0.0820n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM374720
PNG
(14-methyl-6,7,13,14-tetrahydro-1,15- ethenopyrazol...)
Show SMILES CN1Cc2ccccc2OCCNC(=O)c2cnn3ccc1nc23
Show InChI InChI=1S/C17H17N5O2/c1-21-11-12-4-2-3-5-14(12)24-9-7-18-17(23)13-10-19-22-8-6-15(21)20-16(13)22/h2-6,8,10H,7,9,11H2,1H3,(H,18,23)
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n/an/an/a 0.140n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM374722
PNG
(11-fluoro-13-methyl-6,7,13,14-tetrahydro-1,15- eth...)
Show SMILES CC1Nc2ccn3ncc(C(=O)NCCOc4ccc(F)cc14)c3n2
Show InChI InChI=1/C17H16FN5O2/c1-10-12-8-11(18)2-3-14(12)25-7-5-19-17(24)13-9-20-23-6-4-15(21-10)22-16(13)23/h2-4,6,8-10H,5,7H2,1H3,(H,19,24)(H,21,22)
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n/an/an/a 4.30n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM374723
PNG
((13R)-11-fluoro-13-methyl-6,7,13,14- tetrahydro-1,...)
Show SMILES C[C@H]1Nc2ccn3ncc(C(=O)NCCOc4ccc(F)cc14)c3n2
Show InChI InChI=1/C17H16FN5O2/c1-10-12-8-11(18)2-3-14(12)25-7-5-19-17(24)13-9-20-23-6-4-15(21-10)22-16(13)23/h2-4,6,8-10H,5,7H2,1H3,(H,19,24)(H,21,22)/t10-/s2
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n/an/an/a 37n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM374723
PNG
((13R)-11-fluoro-13-methyl-6,7,13,14- tetrahydro-1,...)
Show SMILES C[C@H]1Nc2ccn3ncc(C(=O)NCCOc4ccc(F)cc14)c3n2
Show InChI InChI=1/C17H16FN5O2/c1-10-12-8-11(18)2-3-14(12)25-7-5-19-17(24)13-9-20-23-6-4-15(21-10)22-16(13)23/h2-4,6,8-10H,5,7H2,1H3,(H,19,24)(H,21,22)/t10-/s2
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n/an/an/a 1.80n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM374728
PNG
(11-fluoro-13-(hydroxymethyl)-6,7,13,14- tetrahydro...)
Show SMILES OCC1Nc2ccn3ncc(C(=O)NCCOc4ccc(F)cc14)c3n2
Show InChI InChI=1/C17H16FN5O3/c18-10-1-2-14-11(7-10)13(9-24)21-15-3-5-23-16(22-15)12(8-20-23)17(25)19-4-6-26-14/h1-3,5,7-8,13,24H,4,6,9H2,(H,19,25)(H,21,22)
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n/an/an/a 14n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM374713
PNG
(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Show SMILES CN1Cc2cc(F)ccc2OCCNC(=O)c2cnn3ccc1nc23
Show InChI InChI=1S/C17H16FN5O2/c1-22-10-11-8-12(18)2-3-14(11)25-7-5-19-17(24)13-9-20-23-6-4-15(22)21-16(13)23/h2-4,6,8-9H,5,7,10H2,1H3,(H,19,24)
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n/an/an/a 0.0310n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM374715
PNG
(11-fluoro-3,14-dimethyl-6,7,13,14-tetrahydro-1,15-...)
Show SMILES CN1Cc2cc(F)ccc2OCCNC(=O)c2c(C)nn3ccc1nc23
Show InChI InChI=1S/C18H18FN5O2/c1-11-16-17-21-15(5-7-24(17)22-11)23(2)10-12-9-13(19)3-4-14(12)26-8-6-20-18(16)25/h3-5,7,9H,6,8,10H2,1-2H3,(H,20,25)
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TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM374719
PNG
(11-fluoro-14-(propan-2-yl)-6,7,13,14-tetrahydro- 1...)
Show SMILES CC(C)N1Cc2cc(F)ccc2OCCNC(=O)c2cnn3ccc1nc23
Show InChI InChI=1S/C19H20FN5O2/c1-12(2)24-11-13-9-14(20)3-4-16(13)27-8-6-21-19(26)15-10-22-25-7-5-17(24)23-18(15)25/h3-5,7,9-10,12H,6,8,11H2,1-2H3,(H,21,26)
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n/an/an/a 7.80n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS


()
BDBM374723
PNG
((13R)-11-fluoro-13-methyl-6,7,13,14- tetrahydro-1,...)
Show SMILES C[C@H]1Nc2ccn3ncc(C(=O)NCCOc4ccc(F)cc14)c3n2
Show InChI InChI=1/C17H16FN5O2/c1-10-12-8-11(18)2-3-14(12)25-7-5-19-17(24)13-9-20-23-6-4-15(21-10)22-16(13)23/h2-4,6,8-10H,5,7H2,1H3,(H,19,24)(H,21,22)/t10-/s2
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n/an/an/a 0.730n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM374727
PNG
((7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14- tetrah...)
Show SMILES C[C@H]1CNC(=O)c2cnn3ccc(N[C@H](C)c4cc(F)ccc4O1)nc23
Show InChI InChI=1/C18H18FN5O2/c1-10-8-20-18(25)14-9-21-24-6-5-16(23-17(14)24)22-11(2)13-7-12(19)3-4-15(13)26-10/h3-7,9-11H,8H2,1-2H3,(H,20,25)(H,22,23)/t10-,11+/s2
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n/an/an/a 5.70n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM374728
PNG
(11-fluoro-13-(hydroxymethyl)-6,7,13,14- tetrahydro...)
Show SMILES OCC1Nc2ccn3ncc(C(=O)NCCOc4ccc(F)cc14)c3n2
Show InChI InChI=1/C17H16FN5O3/c18-10-1-2-14-11(7-10)13(9-24)21-15-3-5-23-16(22-15)12(8-20-23)17(25)19-4-6-26-14/h1-3,5,7-8,13,24H,4,6,9H2,(H,19,25)(H,21,22)
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n/an/an/a 0.740n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM374712
PNG
(12-chloro-11-fluoro-13-methyl-6,7-dihydro- 13H-1,1...)
Show SMILES CC1Oc2ccn3ncc(C(=O)NCCOc4ccc(F)c(Cl)c14)c3n2
Show InChI InChI=1/C17H14ClFN4O3/c1-9-14-12(3-2-11(19)15(14)18)25-7-5-20-17(24)10-8-21-23-6-4-13(26-9)22-16(10)23/h2-4,6,8-9H,5,7H2,1H3,(H,20,24)
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n/an/an/a>3.00E+4n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS


()
BDBM374713
PNG
(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Show SMILES CN1Cc2cc(F)ccc2OCCNC(=O)c2cnn3ccc1nc23
Show InChI InChI=1S/C17H16FN5O2/c1-22-10-11-8-12(18)2-3-14(11)25-7-5-19-17(24)13-9-20-23-6-4-15(22)21-16(13)23/h2-4,6,8-9H,5,7,10H2,1H3,(H,19,24)
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n/an/an/a 21n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM374716
PNG
(10-fluoro-8-methyl-15,16-dihydro-8H-3,6- ethenoimi...)
Show SMILES CC1Oc2ccc3ncc(C(=O)NCCOc4ccc(F)cc14)n3n2
Show InChI InChI=1/C17H15FN4O3/c1-10-12-8-11(18)2-3-14(12)24-7-6-19-17(23)13-9-20-15-4-5-16(25-10)21-22(13)15/h2-5,8-10H,6-7H2,1H3,(H,19,23)
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n/an/an/a 200n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM374726
PNG
((7R,13R)-11-fluoro-7,13-dimethyl-6,7,13,14- tetrah...)
Show SMILES C[C@@H]1CNC(=O)c2cnn3ccc(N[C@H](C)c4cc(F)ccc4O1)nc23
Show InChI InChI=1/C18H18FN5O2/c1-10-8-20-18(25)14-9-21-24-6-5-16(23-17(14)24)22-11(2)13-7-12(19)3-4-15(13)26-10/h3-7,9-11H,8H2,1-2H3,(H,20,25)(H,22,23)/t10-,11-/s2
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n/an/an/a 8.20n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM374729
PNG
(12-fluoro-5,6,7,8,14,15-hexahydro-4H-1,16- ethenop...)
Show SMILES Fc1ccc2OCCCNC(=O)c3cnn4ccc(CCc2c1)nc34
Show InChI InChI=1S/C18H17FN4O2/c19-13-3-5-16-12(10-13)2-4-14-6-8-23-17(22-14)15(11-21-23)18(24)20-7-1-9-25-16/h3,5-6,8,10-11H,1-2,4,7,9H2,(H,20,24)
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n/an/an/a 1.90n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM374729
PNG
(12-fluoro-5,6,7,8,14,15-hexahydro-4H-1,16- ethenop...)
Show SMILES Fc1ccc2OCCCNC(=O)c3cnn4ccc(CCc2c1)nc34
Show InChI InChI=1S/C18H17FN4O2/c19-13-3-5-16-12(10-13)2-4-14-6-8-23-17(22-14)15(11-21-23)18(24)20-7-1-9-25-16/h3,5-6,8,10-11H,1-2,4,7,9H2,(H,20,24)
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n/an/an/a 28n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
Neurotrophic tyrosine kinase receptor


(Homo sapiens (Human))
BDBM374713
PNG
(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Show SMILES CN1Cc2cc(F)ccc2OCCNC(=O)c2cnn3ccc1nc23
Show InChI InChI=1S/C17H16FN5O2/c1-22-10-11-8-12(18)2-3-14(11)25-7-5-19-17(24)13-9-20-23-6-4-15(22)21-16(13)23/h2-4,6,8-9H,5,7,10H2,1H3,(H,19,24)
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n/an/an/a 0.180n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM374713
PNG
(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Show SMILES CN1Cc2cc(F)ccc2OCCNC(=O)c2cnn3ccc1nc23
Show InChI InChI=1S/C17H16FN5O2/c1-22-10-11-8-12(18)2-3-14(11)25-7-5-19-17(24)13-9-20-23-6-4-15(22)21-16(13)23/h2-4,6,8-9H,5,7,10H2,1H3,(H,19,24)
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n/an/an/a 120n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM374716
PNG
(10-fluoro-8-methyl-15,16-dihydro-8H-3,6- ethenoimi...)
Show SMILES CC1Oc2ccc3ncc(C(=O)NCCOc4ccc(F)cc14)n3n2
Show InChI InChI=1/C17H15FN4O3/c1-10-12-8-11(18)2-3-14(12)24-7-6-19-17(23)13-9-20-15-4-5-16(25-10)21-22(13)15/h2-5,8-10H,6-7H2,1H3,(H,19,23)
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n/an/an/a 33n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM374718
PNG
(14-ethyl-11-fluoro-6,7,13,14-tetrahydro-1,15- ethe...)
Show SMILES CCN1Cc2cc(F)ccc2OCCNC(=O)c2cnn3ccc1nc23
Show InChI InChI=1S/C18H18FN5O2/c1-2-23-11-12-9-13(19)3-4-15(12)26-8-6-20-18(25)14-10-21-24-7-5-16(23)22-17(14)24/h3-5,7,9-10H,2,6,8,11H2,1H3,(H,20,25)
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n/an/an/a 0.0860n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM374720
PNG
(14-methyl-6,7,13,14-tetrahydro-1,15- ethenopyrazol...)
Show SMILES CN1Cc2ccccc2OCCNC(=O)c2cnn3ccc1nc23
Show InChI InChI=1S/C17H17N5O2/c1-21-11-12-4-2-3-5-14(12)24-9-7-18-17(23)13-10-19-22-8-6-15(21)20-16(13)22/h2-6,8,10H,7,9,11H2,1H3,(H,18,23)
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n/an/an/a 24n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM374723
PNG
((13R)-11-fluoro-13-methyl-6,7,13,14- tetrahydro-1,...)
Show SMILES C[C@H]1Nc2ccn3ncc(C(=O)NCCOc4ccc(F)cc14)c3n2
Show InChI InChI=1/C17H16FN5O2/c1-10-12-8-11(18)2-3-14(12)25-7-5-19-17(24)13-9-20-23-6-4-15(21-10)22-16(13)23/h2-4,6,8-10H,5,7H2,1H3,(H,19,24)(H,21,22)/t10-/s2
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n/an/an/a 6.80n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM374716
PNG
(10-fluoro-8-methyl-15,16-dihydro-8H-3,6- ethenoimi...)
Show SMILES CC1Oc2ccc3ncc(C(=O)NCCOc4ccc(F)cc14)n3n2
Show InChI InChI=1/C17H15FN4O3/c1-10-12-8-11(18)2-3-14(12)24-7-6-19-17(23)13-9-20-15-4-5-16(25-10)21-22(13)15/h2-5,8-10H,6-7H2,1H3,(H,19,23)
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n/an/an/a 280n/an/an/an/an/a



TP Therapeutics, Inc.

US Patent


Assay Description
Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., ďA small molecule-kinase interactio...


US Patent US10246466 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%