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Patent code US10251889

Compile Data Set for Download or QSAR

Found 530 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127782
PNG
(US10251889, Example 155 | US8791123, 155 | US97824...)
Show SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NCCO)c2n1
Show InChI InChI=1/C19H21FN6O3/c1-29-19-13(9-12(20)10-22-19)15-3-2-6-25(15)16-4-7-26-17(24-16)14(11-23-26)18(28)21-5-8-27/h4,7,9-11,15,27H,2-3,5-6,8H2,1H3,(H,21,28)/t15-/s2
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n/an/a 0.200n/an/an/an/an/an/a



Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM344316
PNG
(US10251889, Example 25 | US9782415, Example 25 | U...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NCCc3c[nH]cn3)c2n1
Show InChI InChI=1/C22H21F2N7O/c23-14-3-4-18(24)16(10-14)19-2-1-8-30(19)20-6-9-31-21(29-20)17(12-28-31)22(32)26-7-5-15-11-25-13-27-15/h3-4,6,9-13,19H,1-2,5,7-8H2,(H,25,27)(H,26,32)/t19-/s2
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n/an/a 0.400n/an/an/an/an/an/a



Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127634
PNG
(US10251889, Example 7 | US8791123, 7 | US9782415, ...)
Show SMILES O[C@H]1CC[C@@H](CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C23H25F2N5O2/c24-14-3-8-19(25)17(12-14)20-2-1-10-29(20)21-9-11-30-22(28-21)18(13-26-30)23(32)27-15-4-6-16(31)7-5-15/h3,8-9,11-13,15-16,20,31H,1-2,4-7,10H2,(H,27,32)/t15-,16-,20-/s2
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n/an/a 0.450n/an/an/an/an/an/a



Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127640
PNG
(US10251889, Example 13 | US8791123, 13 | US9782415...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1
Show InChI InChI=1/C20H19F2N5O/c21-12-3-6-16(22)14(10-12)17-2-1-8-26(17)18-7-9-27-19(25-18)15(11-23-27)20(28)24-13-4-5-13/h3,6-7,9-11,13,17H,1-2,4-5,8H2,(H,24,28)/t17-/s2
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n/an/a 0.5n/an/an/an/an/an/a



Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127641
PNG
(US10251889, Example 14 | US8791123, 14 | US9782415...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CCC3)c2n1
Show InChI InChI=1/C21H21F2N5O/c22-13-6-7-17(23)15(11-13)18-5-2-9-27(18)19-8-10-28-20(26-19)16(12-24-28)21(29)25-14-3-1-4-14/h6-8,10-12,14,18H,1-5,9H2,(H,25,29)/t18-/s2
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n/an/a 0.550n/an/an/an/an/an/a



Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127693
PNG
(US10251889, Example 66 | US8791123, 66 | US9782415...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NOCC3CC3)c2n1
Show InChI InChI=1/C21H21F2N5O2/c22-14-5-6-17(23)15(10-14)18-2-1-8-27(18)19-7-9-28-20(25-19)16(11-24-28)21(29)26-30-12-13-3-4-13/h5-7,9-11,13,18H,1-4,8,12H2,(H,26,29)/t18-/s2
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n/an/a 0.570n/an/an/an/an/an/a



Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127647
PNG
(US10251889, Example 20 | US8791123, 20 | US9782415...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CCOCC3)c2n1
Show InChI InChI=1/C22H23F2N5O2/c23-14-3-4-18(24)16(12-14)19-2-1-8-28(19)20-5-9-29-21(27-20)17(13-25-29)22(30)26-15-6-10-31-11-7-15/h3-5,9,12-13,15,19H,1-2,6-8,10-11H2,(H,26,30)/t19-/s2
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n/an/a 0.600n/an/an/an/an/an/a



Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127642
PNG
(US10251889, Example 15 | US8791123, 15 | US9782415...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)N[C@H]3CC4CCC3C4)c2n1
Show InChI InChI=1/C24H25F2N5O/c25-16-5-6-19(26)17(12-16)21-2-1-8-30(21)22-7-9-31-23(29-22)18(13-27-31)24(32)28-20-11-14-3-4-15(20)10-14/h5-7,9,12-15,20-21H,1-4,8,10-11H2,(H,28,32)/t14?,15?,20-,21+/s2
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n/an/a 0.600n/an/an/an/an/an/a



Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127692
PNG
(US10251889, Example 65 | US8791123, 65 | US9782415...)
Show SMILES CONC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C18H17F2N5O2/c1-27-23-18(26)13-10-21-25-8-6-16(22-17(13)25)24-7-2-3-15(24)12-9-11(19)4-5-14(12)20/h4-6,8-10,15H,2-3,7H2,1H3,(H,23,26)/t15-/s2
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n/an/a 0.600n/an/an/an/an/an/a



Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM344339
PNG
(US10251889, Example 48 | US9782415, Example 48 | U...)
Show SMILES OCc1ccc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1
Show InChI InChI=1/C21H22FN5O2/c22-14-4-3-13(12-28)16(10-14)18-2-1-8-26(18)19-7-9-27-20(25-19)17(11-23-27)21(29)24-15-5-6-15/h3-4,7,9-11,15,18,28H,1-2,5-6,8,12H2,(H,24,29)/t18-/s2
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n/an/a 0.600n/an/an/an/an/an/a



Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM344330
PNG
(US10251889, Example 39 | US9782415, Example 39 | U...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NCC#N)c2n1
Show InChI InChI=1/C19H16F2N6O/c20-12-3-4-15(21)13(10-12)16-2-1-8-26(16)17-5-9-27-18(25-17)14(11-24-27)19(28)23-7-6-22/h3-5,9-11,16H,1-2,7-8H2,(H,23,28)/t16-/s2
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n/an/a 0.700n/an/an/an/an/an/a



Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127629
PNG
(US10251889, Example 2 | US8791123, 2 | US9782415, ...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)Nc3ccccn3)c2n1
Show InChI InChI=1/C22H18F2N6O/c23-14-6-7-17(24)15(12-14)18-4-3-10-29(18)20-8-11-30-21(28-20)16(13-26-30)22(31)27-19-5-1-2-9-25-19/h1-2,5-9,11-13,18H,3-4,10H2,(H,25,27,31)/t18-/s2
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n/an/a 0.700n/an/an/an/an/an/a



Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127628
PNG
(US10251889, Example 1 | US8791123, 1 | US9782415, ...)
Show SMILES CC(C)(C)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C21H23F2N5O/c1-21(2,3)26-20(29)15-12-24-28-10-8-18(25-19(15)28)27-9-4-5-17(27)14-11-13(22)6-7-16(14)23/h6-8,10-12,17H,4-5,9H2,1-3H3,(H,26,29)/t17-/s2
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n/an/a 0.700n/an/an/an/an/an/a



Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127667
PNG
(US10251889, Example 40 | US8791123, 40 | US9782415...)
Show SMILES CC(C)(CF)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C21H22F3N5O/c1-21(2,12-22)27-20(30)15-11-25-29-9-7-18(26-19(15)29)28-8-3-4-17(28)14-10-13(23)5-6-16(14)24/h5-7,9-11,17H,3-4,8,12H2,1-2H3,(H,27,30)/t17-/s2
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n/an/a 0.800n/an/an/an/an/an/a



Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM127767
PNG
(US10251889, Example 140 | US8791123, 140 | US97824...)
Show SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC[C@H](O)CC3)c2n1
Show InChI InChI=1/C23H27FN6O3/c1-33-23-17(11-14(24)12-25-23)19-3-2-9-29(19)20-8-10-30-21(28-20)18(13-26-30)22(32)27-15-4-6-16(31)7-5-15/h8,10-13,15-16,19,31H,2-7,9H2,1H3,(H,27,32)/t15?,16-,19-/s2
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n/an/a 0.900n/an/an/an/an/an/a



Array BioPharm Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia™ Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) an...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127796
PNG
(US10251889, Example 169 | US8791123, 169 | US97824...)
Show SMILES O[C@H]1CC[C@@H](C1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C22H23F2N5O2/c23-13-3-6-18(24)16(10-13)19-2-1-8-28(19)20-7-9-29-21(27-20)17(12-25-29)22(31)26-14-4-5-15(30)11-14/h3,6-7,9-10,12,14-15,19,30H,1-2,4-5,8,11H2,(H,26,31)/t14-,15-,19+/s2
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n/an/a 0.900n/an/an/an/an/an/a



Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127767
PNG
(US10251889, Example 140 | US8791123, 140 | US97824...)
Show SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC[C@H](O)CC3)c2n1
Show InChI InChI=1/C23H27FN6O3/c1-33-23-17(11-14(24)12-25-23)19-3-2-9-29(19)20-8-10-30-21(28-20)18(13-26-30)22(32)27-15-4-6-16(31)7-5-15/h8,10-13,15-16,19,31H,2-7,9H2,1H3,(H,27,32)/t15?,16-,19-/s2
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n/an/a 0.900n/an/an/an/an/an/a



Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127643
PNG
(US10251889, Example 16 | US8791123, 16 | US9782415...)
Show SMILES OCC1(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C21H21F2N5O2/c22-13-3-4-16(23)14(10-13)17-2-1-8-27(17)18-5-9-28-19(25-18)15(11-24-28)20(30)26-21(12-29)6-7-21/h3-5,9-11,17,29H,1-2,6-8,12H2,(H,26,30)/t17-/s2
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n/an/a 0.900n/an/an/an/an/an/a



Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127717
PNG
(US10251889, Example 90 | US8791123, 90 | US9782415...)
Show SMILES COCCOc1ccc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1
Show InChI InChI=1/C23H26FN5O3/c1-31-11-12-32-20-7-4-15(24)13-17(20)19-3-2-9-28(19)21-8-10-29-22(27-21)18(14-25-29)23(30)26-16-5-6-16/h4,7-8,10,13-14,16,19H,2-3,5-6,9,11-12H2,1H3,(H,26,30)/t19-/s2
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n/an/a 0.950n/an/an/an/an/an/a



Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127631
PNG
(US10251889, Example 4 | US8791123, 4 | US9782415, ...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NCCN3CCOCC3)c2n1
Show InChI InChI=1/C23H26F2N6O2/c24-16-3-4-19(25)17(14-16)20-2-1-7-30(20)21-5-8-31-22(28-21)18(15-27-31)23(32)26-6-9-29-10-12-33-13-11-29/h3-5,8,14-15,20H,1-2,6-7,9-13H2,(H,26,32)/t20-/s2
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n/an/a 0.950n/an/an/an/an/an/a



Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127632
PNG
(US10251889, Example 5 | US8791123, 5 | US9782415, ...)
Show SMILES Cc1ccc(CNC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)ccc2F)o1
Show InChI InChI=1/C23H21F2N5O2/c1-14-4-6-16(32-14)12-26-23(31)18-13-27-30-10-8-21(28-22(18)30)29-9-2-3-20(29)17-11-15(24)5-7-19(17)25/h4-8,10-11,13,20H,2-3,9,12H2,1H3,(H,26,31)/t20-/s2
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n/an/a 0.950n/an/an/an/an/an/a



Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM344346
PNG
(US10251889, Example 55 | US9782415, Example 55 | U...)
Show SMILES OC[C@@H](O)CNC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1CO
Show InChI InChI=1/C21H24FN5O4/c22-14-4-3-13(11-28)16(8-14)18-2-1-6-26(18)19-5-7-27-20(25-19)17(10-24-27)21(31)23-9-15(30)12-29/h3-5,7-8,10,15,18,28-30H,1-2,6,9,11-12H2,(H,23,31)/t15-,18+/s2
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n/an/a 1n/an/an/an/an/an/a



Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127637
PNG
(US10251889, Example 10 | US8791123, 10 | US9782415...)
Show SMILES CNC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C18H17F2N5O/c1-21-18(26)13-10-22-25-8-6-16(23-17(13)25)24-7-2-3-15(24)12-9-11(19)4-5-14(12)20/h4-6,8-10,15H,2-3,7H2,1H3,(H,21,26)/t15-/s2
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Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127650
PNG
(US10251889, Example 23 | US8791123, 23 | US9782415...)
Show SMILES Cn1cncc1CCNC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C23H23F2N7O/c1-30-14-26-12-16(30)6-8-27-23(33)18-13-28-32-10-7-21(29-22(18)32)31-9-2-3-20(31)17-11-15(24)4-5-19(17)25/h4-5,7,10-14,20H,2-3,6,8-9H2,1H3,(H,27,33)/t20-/s2
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Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127792
PNG
(US10251889, Example 165 | US8791123, 165 | US97824...)
Show SMILES OCCNC(=O)c1cnn2ccc(nc12)N1CCCC1c1cc(F)ccc1F
Show InChI InChI=1/C19H19F2N5O2/c20-12-3-4-15(21)13(10-12)16-2-1-7-25(16)17-5-8-26-18(24-17)14(11-23-26)19(28)22-6-9-27/h3-5,8,10-11,16,27H,1-2,6-7,9H2,(H,22,28)
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Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127635
PNG
(US10251889, Example 8 | US8791123, 8 | US9782415, ...)
Show SMILES CC(C)(CO)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C21H23F2N5O2/c1-21(2,12-29)26-20(30)15-11-24-28-9-7-18(25-19(15)28)27-8-3-4-17(27)14-10-13(22)5-6-16(14)23/h5-7,9-11,17,29H,3-4,8,12H2,1-2H3,(H,26,30)/t17-/s2
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Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM344325
PNG
(US10251889, Example 34 | US9782415, Example 34 | U...)
Show SMILES OCc1ccc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)N[C@H]3CC[C@H](O)CC3)c2n1
Show InChI InChI=1/C24H28FN5O3/c25-16-4-3-15(14-31)19(12-16)21-2-1-10-29(21)22-9-11-30-23(28-22)20(13-26-30)24(33)27-17-5-7-18(32)8-6-17/h3-4,9,11-13,17-18,21,31-32H,1-2,5-8,10,14H2,(H,27,33)/t17-,18-,21-/s2
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Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127775
PNG
(US10251889, Example 148 | US8791123, 148 | US97824...)
Show SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NCCCO)c2n1
Show InChI InChI=1/C20H23FN6O3/c1-30-20-14(10-13(21)11-23-20)16-4-2-7-26(16)17-5-8-27-18(25-17)15(12-24-27)19(29)22-6-3-9-28/h5,8,10-12,16,28H,2-4,6-7,9H2,1H3,(H,22,29)/t16-/s2
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Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM344372
PNG
(US10251889, Example 81 | US9782415, Example 81 | U...)
Show SMILES CC(C)(CF)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)cnc1CO
Show InChI InChI=1/C21H24F2N6O2/c1-21(2,12-22)27-20(31)15-10-25-29-7-5-18(26-19(15)29)28-6-3-4-17(28)14-8-13(23)9-24-16(14)11-30/h5,7-10,17,30H,3-4,6,11-12H2,1-2H3,(H,27,31)/t17-/s2
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Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127677
PNG
(US10251889, Example 51 | US8791123, 50 | US9782415...)
Show SMILES C[C@@]1(O)CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C24H27F2N5O2/c1-24(33)9-6-16(7-10-24)28-23(32)18-14-27-31-12-8-21(29-22(18)31)30-11-2-3-20(30)17-13-15(25)4-5-19(17)26/h4-5,8,12-14,16,20,33H,2-3,6-7,9-11H2,1H3,(H,28,32)/t16?,20-,24-/s2
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Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127795
PNG
(US10251889, Example 168 | US8791123, 168 | US97967...)
Show SMILES CC(C)(CO)CNC(=O)c1cnn2ccc(nc12)N1CCCC1c1cc(F)ccc1F
Show InChI InChI=1/C22H25F2N5O2/c1-22(2,13-30)12-25-21(31)16-11-26-29-9-7-19(27-20(16)29)28-8-3-4-18(28)15-10-14(23)5-6-17(15)24/h5-7,9-11,18,30H,3-4,8,12-13H2,1-2H3,(H,25,31)
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Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127662
PNG
(US10251889, Example 35 | US8791123, 35 | US9782415...)
Show SMILES O[C@H]1CC[C@@H](CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1
Show InChI InChI=1/C23H26FN5O2/c24-16-4-1-3-15(13-16)20-5-2-11-28(20)21-10-12-29-22(27-21)19(14-25-29)23(31)26-17-6-8-18(30)9-7-17/h1,3-4,10,12-14,17-18,20,30H,2,5-9,11H2,(H,26,31)/t17-,18-,20-/s2
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Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127677
PNG
(US10251889, Example 51 | US8791123, 50 | US9782415...)
Show SMILES C[C@@]1(O)CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C24H27F2N5O2/c1-24(33)9-6-16(7-10-24)28-23(32)18-14-27-31-12-8-21(29-22(18)31)30-11-2-3-20(30)17-13-15(25)4-5-19(17)26/h4-5,8,12-14,16,20,33H,2-3,6-7,9-11H2,1H3,(H,28,32)/t16?,20-,24-/s2
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Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM344329
PNG
(US10251889, Example 38 | US9782415, Example 38 | U...)
Show SMILES CC(C)(NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F)C#N
Show InChI InChI=1/C21H20F2N6O/c1-21(2,12-24)27-20(30)15-11-25-29-9-7-18(26-19(15)29)28-8-3-4-17(28)14-10-13(22)5-6-16(14)23/h5-7,9-11,17H,3-4,8H2,1-2H3,(H,27,30)/t17-/s2
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Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127781
PNG
(US10251889, Example 154 | US8791123, 154 | US97824...)
Show SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)N[C@H]3CC[C@H](O)C3)c2n1
Show InChI InChI=1/C22H25FN6O3/c1-32-22-16(9-13(23)11-24-22)18-3-2-7-28(18)19-6-8-29-20(27-19)17(12-25-29)21(31)26-14-4-5-15(30)10-14/h6,8-9,11-12,14-15,18,30H,2-5,7,10H2,1H3,(H,26,31)/t14-,15-,18+/s2
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Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127656
PNG
(US10251889, Example 29 | US8791123, 29 | US9782415...)
Show SMILES OC[C@@H](O)CNC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C20H21F2N5O3/c21-12-3-4-16(22)14(8-12)17-2-1-6-26(17)18-5-7-27-19(25-18)15(10-24-27)20(30)23-9-13(29)11-28/h3-5,7-8,10,13,17,28-29H,1-2,6,9,11H2,(H,23,30)/t13-,17+/s2
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Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127653
PNG
(US10251889, Example 26 | US8791123, 26 | US9782415...)
Show SMILES OC[C@H](O)CNC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C20H21F2N5O3/c21-12-3-4-16(22)14(8-12)17-2-1-6-26(17)18-5-7-27-19(25-18)15(10-24-27)20(30)23-9-13(29)11-28/h3-5,7-8,10,13,17,28-29H,1-2,6,9,11H2,(H,23,30)/t13-,17-/s2
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Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM344370
PNG
(US10251889, Example 79 | US9782415, Example 79 | U...)
Show SMILES OCc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1
Show InChI InChI=1/C20H21FN6O2/c21-12-8-14(16(11-28)22-9-12)17-2-1-6-26(17)18-5-7-27-19(25-18)15(10-23-27)20(29)24-13-3-4-13/h5,7-10,13,17,28H,1-4,6,11H2,(H,24,29)/t17-/s2
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Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127778
PNG
(US10251889, Example 151 | US8791123, 151 | US97824...)
Show SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NCCCCO)c2n1
Show InChI InChI=1/C21H25FN6O3/c1-31-21-15(11-14(22)12-24-21)17-5-4-8-27(17)18-6-9-28-19(26-18)16(13-25-28)20(30)23-7-2-3-10-29/h6,9,11-13,17,29H,2-5,7-8,10H2,1H3,(H,23,30)/t17-/s2
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Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM344336
PNG
(US10251889, Example 45 | US9782415, Example 45 | U...)
Show SMILES NS(=O)(=O)N1CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C22H25F2N7O3S/c23-14-3-4-18(24)16(12-14)19-2-1-8-30(19)20-7-11-31-21(28-20)17(13-26-31)22(32)27-15-5-9-29(10-6-15)35(25,33)34/h3-4,7,11-13,15,19H,1-2,5-6,8-10H2,(H,27,32)(H2,25,33,34)/t19-/s2
PDB

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Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127800
PNG
(US10251889, Example 173 | US8791123, 173 | US97824...)
Show SMILES OCC(CO)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C20H21F2N5O3/c21-12-3-4-16(22)14(8-12)17-2-1-6-26(17)18-5-7-27-19(25-18)15(9-23-27)20(30)24-13(10-28)11-29/h3-5,7-9,13,17,28-29H,1-2,6,10-11H2,(H,24,30)/t17-/s2
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n/an/a 1.5n/an/an/an/an/an/a



Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM344335
PNG
(US10251889, Example 44 | US9782415, Example 44 | U...)
Show SMILES CS(=O)(=O)N1CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C23H26F2N6O3S/c1-35(33,34)29-10-6-16(7-11-29)27-23(32)18-14-26-31-12-8-21(28-22(18)31)30-9-2-3-20(30)17-13-15(24)4-5-19(17)25/h4-5,8,12-14,16,20H,2-3,6-7,9-11H2,1H3,(H,27,32)/t20-/s2
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Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM344324
PNG
(US10251889, Example 33 | US9782415, Example 33 | U...)
Show SMILES OC(=O)[C@H]1CC[C@@H](CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C24H25F2N5O3/c25-15-5-8-19(26)17(12-15)20-2-1-10-30(20)21-9-11-31-22(29-21)18(13-27-31)23(32)28-16-6-3-14(4-7-16)24(33)34/h5,8-9,11-14,16,20H,1-4,6-7,10H2,(H,28,32)(H,33,34)/t14-,16-,20-/s2
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Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM344338
PNG
(US10251889, Example 47 | US9782415, Example 47 | U...)
Show SMILES NS(=O)(=O)CCNC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C19H20F2N6O3S/c20-12-3-4-15(21)13(10-12)16-2-1-7-26(16)17-5-8-27-18(25-17)14(11-24-27)19(28)23-6-9-31(22,29)30/h3-5,8,10-11,16H,1-2,6-7,9H2,(H,23,28)(H2,22,29,30)/t16-/s2
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n/an/a 1.5n/an/an/an/an/an/a



Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127633
PNG
(US10251889, Example 6 | US8791123, 6 | US9782415, ...)
Show SMILES Cn1ccc(NC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)ccc2F)n1
Show InChI InChI=1/C21H19F2N7O/c1-28-9-6-18(27-28)25-21(31)15-12-24-30-10-7-19(26-20(15)30)29-8-2-3-17(29)14-11-13(22)4-5-16(14)23/h4-7,9-12,17H,2-3,8H2,1H3,(H,25,27,31)/t17-/s2
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n/an/a 1.55n/an/an/an/an/an/a



Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127691
PNG
(US10251889, Example 64 | US8791123, 64 | US9782415...)
Show SMILES NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1C(F)(F)F
Show InChI InChI=1/C18H15F4N5O/c19-10-3-4-13(18(20,21)22)11(8-10)14-2-1-6-26(14)15-5-7-27-17(25-15)12(9-24-27)16(23)28/h3-5,7-9,14H,1-2,6H2,(H2,23,28)/t14-/s2
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n/an/a 1.60n/an/an/an/an/an/a



Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127664
PNG
(US10251889, Example 37 | US8791123, 37 | US9782415...)
Show SMILES Fc1cccc(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1
Show InChI InChI=1/C20H20FN5O/c21-14-4-1-3-13(11-14)17-5-2-9-25(17)18-8-10-26-19(24-18)16(12-22-26)20(27)23-15-6-7-15/h1,3-4,8,10-12,15,17H,2,5-7,9H2,(H,23,27)/t17-/s2
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Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127835
PNG
(US10251889, Example 208 | US8791123, 208 | US97824...)
Show SMILES OCC(O)COc1cc(F)cc(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1
Show InChI InChI=1/C23H26FN5O4/c24-15-8-14(9-18(10-15)33-13-17(31)12-30)20-2-1-6-28(20)21-5-7-29-22(27-21)19(11-25-29)23(32)26-16-3-4-16/h5,7-11,16-17,20,30-31H,1-4,6,12-13H2,(H,26,32)/t17?,20-/s2
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n/an/a 1.70n/an/an/an/an/an/a



Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM127757
PNG
(US10251889, Example 130 | US8791123, 130 | US97824...)
Show SMILES C[C@H](NC(=O)c1cnn2ccc(nc12)N1CCCC1c1cncc(F)c1)C(F)(F)F
Show InChI InChI=1/C19H18F4N6O/c1-11(19(21,22)23)26-18(30)14-10-25-29-6-4-16(27-17(14)29)28-5-2-3-15(28)12-7-13(20)9-24-8-12/h4,6-11,15H,2-3,5H2,1H3,(H,26,30)/t11-,15?/s2
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Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM344374
PNG
(US10251889, Example 83 | US9782415, Example 83 | U...)
Show SMILES CONC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)cnc1CO
Show InChI InChI=1/C18H19FN6O3/c1-28-23-18(27)13-9-21-25-6-4-16(22-17(13)25)24-5-2-3-15(24)12-7-11(19)8-20-14(12)10-26/h4,6-9,15,26H,2-3,5,10H2,1H3,(H,23,27)/t15-/s2
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n/an/a 1.77n/an/an/an/an/an/a



Array BioPharm Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10251889 (2019)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%