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Patent code US10251892

Compile Data Set for Download or QSAR

Found 856 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261995
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3ccccn3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C26H24F2N6O3/c1-15-18(14-32(2)31-15)19-9-20-16(11-30-19)12-34(26(35)33(20)13-17-7-5-6-8-29-17)25-23(27)21(36-3)10-22(37-4)24(25)28/h5-11,14H,12-13H2,1-4H3
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM261996
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3csc(C)n3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C25H24F2N6O3S/c1-13-17(11-31(3)30-13)18-6-19-15(8-28-18)9-33(25(34)32(19)10-16-12-37-14(2)29-16)24-22(26)20(35-4)7-21(36-5)23(24)27/h6-8,11-12H,9-10H2,1-5H3
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262014
PNG
(4-(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- d...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C2=O)c2ccc(cc2)C(=O)N(C)C)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C29H28F2N6O4/c1-16-20(15-35(4)33-16)21-11-22-18(13-32-21)14-36(27-25(30)23(40-5)12-24(41-6)26(27)31)29(39)37(22)19-9-7-17(8-10-19)28(38)34(2)3/h7-13,15H,14H2,1-6H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262018
PNG
(Methyl 4-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(...)
Show SMILES COC(=O)Nc1ccc(cc1)N1C(=O)N(Cc2cnc(cc12)-c1cn(C)nc1C)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C28H26F2N6O5/c1-15-19(14-34(2)33-15)20-10-21-16(12-31-20)13-35(26-24(29)22(39-3)11-23(40-4)25(26)30)28(38)36(21)18-8-6-17(7-9-18)32-27(37)41-5/h6-12,14H,13H2,1-5H3,(H,32,37)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262026
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C2=O)c2ccc3[nH]ncc3c2)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C27H23F2N7O3/c1-14-18(13-34(2)33-14)20-8-21-16(10-30-20)12-35(26-24(28)22(38-3)9-23(39-4)25(26)29)27(37)36(21)17-5-6-19-15(7-17)11-31-32-19/h5-11,13H,12H2,1-4H3,(H,31,32)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM262039
PNG
(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(1-(2- m...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cnn(CCN3CCOCC3)c2)c1F
Show InChI InChI=1S/C27H29F2N5O4/c1-36-21-12-22(37-2)24(29)25(23(21)28)34-16-17-13-30-20(11-19(17)27(3-4-27)26(34)35)18-14-31-33(15-18)6-5-32-7-9-38-10-8-32/h11-15H,3-10,16H2,1-2H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262043
PNG
(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(1-(2-(3...)
Show SMILES COC1CCN(CCn2cc(cn2)-c2cc3c(CN(C(=O)C33CC3)c3c(F)c(OC)cc(OC)c3F)cn2)C1
Show InChI InChI=1/C28H31F2N5O4/c1-37-19-4-7-33(16-19)8-9-34-14-18(13-32-34)21-10-20-17(12-31-21)15-35(27(36)28(20)5-6-28)26-24(29)22(38-2)11-23(39-3)25(26)30/h10-14,19H,4-9,15-16H2,1-3H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262045
PNG
(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(3-methy...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cn(nc2C)C2CCN(C)C2)c1F
Show InChI InChI=1/C27H29F2N5O3/c1-15-18(14-34(31-15)17-5-8-32(2)13-17)20-9-19-16(11-30-20)12-33(26(35)27(19)6-7-27)25-23(28)21(36-3)10-22(37-4)24(25)29/h9-11,14,17H,5-8,12-13H2,1-4H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262047
PNG
(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(3-methy...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cn(CCC3CCNCC3)nc2C)c1F
Show InChI InChI=1S/C29H33F2N5O3/c1-17-20(16-35(34-17)11-6-18-4-9-32-10-5-18)22-12-21-19(14-33-22)15-36(28(37)29(21)7-8-29)27-25(30)23(38-2)13-24(39-3)26(27)31/h12-14,16,18,32H,4-11,15H2,1-3H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262060
PNG
(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2-...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1ccc(nc1)C(=O)NC(C)C)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C26H27F2N5O4/c1-6-32-19-9-18(15-7-8-17(29-11-15)25(34)31-14(2)3)30-12-16(19)13-33(26(32)35)24-22(27)20(36-4)10-21(37-5)23(24)28/h7-12,14H,6,13H2,1-5H3,(H,31,34)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262065
PNG
(1-(4-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1ccc(cc1)C1(CC1)C#N)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C27H24F2N4O3/c1-4-32-20-11-19(16-5-7-18(8-6-16)27(15-30)9-10-27)31-13-17(20)14-33(26(32)34)25-23(28)21(35-2)12-22(36-3)24(25)29/h5-8,11-13H,4,9-10,14H2,1-3H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM262068
PNG
(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-6̸...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cnn(C)c2)c1F
Show InChI InChI=1S/C22H20F2N4O3/c1-27-10-13(9-26-27)15-6-14-12(8-25-15)11-28(21(29)22(14)4-5-22)20-18(23)16(30-2)7-17(31-3)19(20)24/h6-10H,4-5,11H2,1-3H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM261910
PNG
(6′-(5-(1H-imidazol-1-yl)pyridin-3-yl)-2̸...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cncc(c2)-n2ccnc2)c1F
Show InChI InChI=1S/C26H21F2N5O3/c1-35-20-9-21(36-2)23(28)24(22(20)27)33-13-16-11-31-19(8-18(16)26(3-4-26)25(33)34)15-7-17(12-30-10-15)32-6-5-29-14-32/h5-12,14H,3-4,13H2,1-2H3
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US Patent


Assay Description
In the FGFR Enzymatic Assay after dilution in assay buffer, added to the plate and pre-incubated for 5 to 10 minutes.


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM261912
PNG
(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-6̸...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cncc(c2)S(=O)(=O)N2CCOCC2)c1F
Show InChI InChI=1S/C27H26F2N4O6S/c1-37-21-11-22(38-2)24(29)25(23(21)28)33-15-17-13-31-20(10-19(17)27(3-4-27)26(33)34)16-9-18(14-30-12-16)40(35,36)32-5-7-39-8-6-32/h9-14H,3-8,15H2,1-2H3
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US Patent


Assay Description
In the FGFR Enzymatic Assay after dilution in assay buffer, added to the plate and pre-incubated for 5 to 10 minutes.


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261969
PNG
(US10251892, Example 69 | US9708318, 69)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3ccncc3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C26H24F2N6O3/c1-15-18(14-32(2)31-15)19-9-20-17(11-30-19)13-34(26(35)33(20)12-16-5-7-29-8-6-16)25-23(27)21(36-3)10-22(37-4)24(25)28/h5-11,14H,12-13H2,1-4H3
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Incyte Corporation

US Patent


Assay Description
In the FGFR Enzymatic Assay after dilution in assay buffer, added to the plate and pre-incubated for 5 to 10 minutes.


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261979
PNG
(3-(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- d...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C2=O)c2cc(F)cc(c2)C#N)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C27H21F3N6O3/c1-14-19(13-34(2)33-14)20-8-21-16(11-32-20)12-35(26-24(29)22(38-3)9-23(39-4)25(26)30)27(37)36(21)18-6-15(10-31)5-17(28)7-18/h5-9,11,13H,12H2,1-4H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261983
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3ncc(C)o3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C25H24F2N6O4/c1-13-8-29-21(37-13)12-32-18-6-17(16-11-31(3)30-14(16)2)28-9-15(18)10-33(25(32)34)24-22(26)19(35-4)7-20(36-5)23(24)27/h6-9,11H,10,12H2,1-5H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261989
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3cccnn3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C25H23F2N7O3/c1-14-17(13-32(2)31-14)18-8-19-15(10-28-18)11-34(25(35)33(19)12-16-6-5-7-29-30-16)24-22(26)20(36-3)9-21(37-4)23(24)27/h5-10,13H,11-12H2,1-4H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261990
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C2=O)c2cccc(c2)-c2cnnn2C)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C29H26F2N8O3/c1-16-20(15-36(2)34-16)21-10-22-18(12-32-21)14-38(28-26(30)24(41-4)11-25(42-5)27(28)31)29(40)39(22)19-8-6-7-17(9-19)23-13-33-35-37(23)3/h6-13,15H,14H2,1-5H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261994
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3cc(on3)C(C)C)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C27H28F2N6O4/c1-14(2)21-7-17(32-39-21)12-34-20-8-19(18-13-33(4)31-15(18)3)30-10-16(20)11-35(27(34)36)26-24(28)22(37-5)9-23(38-6)25(26)29/h7-10,13-14H,11-12H2,1-6H3
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262000
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C2=O)c2cccc(F)c2)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C26H22F3N5O3/c1-14-18(13-32(2)31-14)19-9-20-15(11-30-19)12-33(26(35)34(20)17-7-5-6-16(27)8-17)25-23(28)21(36-3)10-22(37-4)24(25)29/h5-11,13H,12H2,1-4H3
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262013
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cnc(cn1)N1C(=O)N(Cc2cnc(cc12)-c1cn(C)nc1C)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C25H23F2N7O4/c1-13-15(12-32(2)31-13)16-6-17-14(8-28-16)11-33(24-22(26)18(36-3)7-19(37-4)23(24)27)25(35)34(17)20-9-30-21(38-5)10-29-20/h6-10,12H,11H2,1-5H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262035
PNG
(2-(4-(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-3'-ox...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cn(CC#N)nc2C)c1F
Show InChI InChI=1S/C24H21F2N5O3/c1-13-15(12-30(29-13)7-6-27)17-8-16-14(10-28-17)11-31(23(32)24(16)4-5-24)22-20(25)18(33-2)9-19(34-3)21(22)26/h8-10,12H,4-5,7,11H2,1-3H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262042
PNG
(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(2- (dim...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2csc(n2)N(C)C)c1F
Show InChI InChI=1S/C23H22F2N4O3S/c1-28(2)22-27-15(11-33-22)14-7-13-12(9-26-14)10-29(21(30)23(13)5-6-23)20-18(24)16(31-3)8-17(32-4)19(20)25/h7-9,11H,5-6,10H2,1-4H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262063
PNG
(1-(4-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1ccc(cc1)C1(CCC1)C#N)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C28H26F2N4O3/c1-4-33-21-12-20(17-6-8-19(9-7-17)28(16-31)10-5-11-28)32-14-18(21)15-34(27(33)35)26-24(29)22(36-2)13-23(37-3)25(26)30/h6-9,12-14H,4-5,10-11,15H2,1-3H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM261958
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(CN2C(=O)N(Cc3cnc(cc23)-c2cn(C)nc2C)c2c(F)c(OC)cc(OC)c2F)ccn1
Show InChI InChI=1S/C27H26F2N6O4/c1-15-18(14-33(2)32-15)19-9-20-17(11-31-19)13-35(26-24(28)21(37-3)10-22(38-4)25(26)29)27(36)34(20)12-16-6-7-30-23(8-16)39-5/h6-11,14H,12-13H2,1-5H3
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US Patent


Assay Description
In the FGFR Enzymatic Assay after dilution in assay buffer, added to the plate and pre-incubated for 5 to 10 minutes.


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262089
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-ethyl-1...)
Show SMILES CCn1cc(CN2C(=O)N(Cc3cnc(cc23)-c2cnn(C)c2)c2c(F)c(OC)cc(OC)c2F)cn1
Show InChI InChI=1S/C25H25F2N7O3/c1-5-32-11-15(8-30-32)12-33-19-6-18(16-10-29-31(2)13-16)28-9-17(19)14-34(25(33)35)24-22(26)20(36-3)7-21(37-4)23(24)27/h6-11,13H,5,12,14H2,1-4H3
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US Patent


Assay Description
In the FGFR Enzymatic Assay after dilution in assay buffer, added to the plate and pre-incubated for 5 to 10 minutes.


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM261914
PNG
(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-6̸...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cncc(CN3CCOCC3)c2)c1F
Show InChI InChI=1S/C28H28F2N4O4/c1-36-22-11-23(37-2)25(30)26(24(22)29)34-16-19-14-32-21(10-20(19)28(3-4-28)27(34)35)18-9-17(12-31-13-18)15-33-5-7-38-8-6-33/h9-14H,3-8,15-16H2,1-2H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262074
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C2=O)c2ccc3NC(=O)Cc3c2)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C28H24F2N6O4/c1-14-18(13-34(2)33-14)20-9-21-16(11-31-20)12-35(27-25(29)22(39-3)10-23(40-4)26(27)30)28(38)36(21)17-5-6-19-15(7-17)8-24(37)32-19/h5-7,9-11,13H,8,12H2,1-4H3,(H,32,37)
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US Patent


Assay Description
In the FGFR Enzymatic Assay after dilution in assay buffer, added to the plate and pre-incubated for 5 to 10 minutes.


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM262079
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-(2,2-di...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3cnn(CC(F)F)c3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C26H25F4N7O3/c1-14-17(12-34(2)33-14)18-5-19-16(8-31-18)11-37(25-23(29)20(39-3)6-21(40-4)24(25)30)26(38)36(19)10-15-7-32-35(9-15)13-22(27)28/h5-9,12,22H,10-11,13H2,1-4H3
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US Patent


Assay Description
In the FGFR Enzymatic Assay after dilution in assay buffer, added to the plate and pre-incubated for 5 to 10 minutes.


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM262068
PNG
(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-6̸...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cnn(C)c2)c1F
Show InChI InChI=1S/C22H20F2N4O3/c1-27-10-13(9-26-27)15-6-14-12(8-25-15)11-28(21(29)22(14)4-5-22)20-18(23)16(30-2)7-17(31-3)19(20)24/h6-10H,4-5,11H2,1-3H3
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US Patent


Assay Description
In the FGFR Enzymatic Assay after dilution in assay buffer, added to the plate and pre-incubated for 5 to 10 minutes.


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262069
PNG
(1-(5-{3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-[(5-m...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3nnc(C)o3)C2=O)-c2ccc(nc2)C2(CCC2)C#N)c1F
Show InChI InChI=1S/C29H25F2N7O4/c1-16-35-36-24(42-16)14-37-20-9-19(17-5-6-23(34-11-17)29(15-32)7-4-8-29)33-12-18(20)13-38(28(37)39)27-25(30)21(40-2)10-22(41-3)26(27)31/h5-6,9-12H,4,7-8,13-14H2,1-3H3
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US Patent


Assay Description
In the FGFR Enzymatic Assay after dilution in assay buffer, added to the plate and pre-incubated for 5 to 10 minutes.


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM261923
PNG
((S)-1-(4-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-e...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1ccc(CN2CC[C@@H](C2)C#N)cc1)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1/C29H29F2N5O3/c1-4-35-23-11-22(20-7-5-18(6-8-20)15-34-10-9-19(13-32)16-34)33-14-21(23)17-36(29(35)37)28-26(30)24(38-2)12-25(39-3)27(28)31/h5-8,11-12,14,19H,4,9-10,15-17H2,1-3H3/t19-/s2
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261927
PNG
(1-(cyclopropylmethyl)-3-(2,6-difluoro-3,5-dimethox...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(CC3CC3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C24H25F2N5O3/c1-13-16(12-29(2)28-13)17-7-18-15(9-27-17)11-31(24(32)30(18)10-14-5-6-14)23-21(25)19(33-3)8-20(34-4)22(23)26/h7-9,12,14H,5-6,10-11H2,1-4H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261928
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)
Show SMILES CCCN1C(=O)N(Cc2cnc(cc12)-c1cn(C)nc1C)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C23H25F2N5O3/c1-6-7-29-17-8-16(15-12-28(3)27-13(15)2)26-10-14(17)11-30(23(29)31)22-20(24)18(32-4)9-19(33-5)21(22)25/h8-10,12H,6-7,11H2,1-5H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM261936
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(CC3CCOCC3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C26H29F2N5O4/c1-15-18(14-31(2)30-15)19-9-20-17(11-29-19)13-33(26(34)32(20)12-16-5-7-37-8-6-16)25-23(27)21(35-3)10-22(36-4)24(25)28/h9-11,14,16H,5-8,12-13H2,1-4H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM261939
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C2=O)c2ccc(F)cc2)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C26H22F3N5O3/c1-14-18(13-32(2)31-14)19-9-20-15(11-30-19)12-33(26(35)34(20)17-7-5-16(27)6-8-17)25-23(28)21(36-3)10-22(37-4)24(25)29/h5-11,13H,12H2,1-4H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261943
PNG
(4-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dim...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C2=O)c2ccc(cc2)C#N)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C27H22F2N6O3/c1-15-19(14-33(2)32-15)20-9-21-17(12-31-20)13-34(26-24(28)22(37-3)10-23(38-4)25(26)29)27(36)35(21)18-7-5-16(11-30)6-8-18/h5-10,12,14H,13H2,1-4H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261948
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-7-(3-...)
Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1cn(CCN2CCOCC2)nc1C)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C27H32F2N6O4/c1-5-34-21-12-20(19-16-33(31-17(19)2)7-6-32-8-10-39-11-9-32)30-14-18(21)15-35(27(34)36)26-24(28)22(37-3)13-23(38-4)25(26)29/h12-14,16H,5-11,15H2,1-4H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261975
PNG
(5-((3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- ...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3ccc(nc3)C#N)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C27H23F2N7O3/c1-15-19(14-34(2)33-15)20-7-21-17(11-32-20)13-36(26-24(28)22(38-3)8-23(39-4)25(26)29)27(37)35(21)12-16-5-6-18(9-30)31-10-16/h5-8,10-11,14H,12-13H2,1-4H3
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM261965
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3ccncn3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C25H23F2N7O3/c1-14-17(12-32(2)31-14)18-7-19-15(9-29-18)10-34(25(35)33(19)11-16-5-6-28-13-30-16)24-22(26)20(36-3)8-21(37-4)23(24)27/h5-9,12-13H,10-11H2,1-4H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261978
PNG
(1-(4-(1H-pyrazol-1-yl)phenyl)- 3-(2,6-difluoro-3,5...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C2=O)c2ccc(cc2)-n2cccn2)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C29H25F2N7O3/c1-17-21(16-35(2)34-17)22-12-23-18(14-32-22)15-36(28-26(30)24(40-3)13-25(41-4)27(28)31)29(39)38(23)20-8-6-19(7-9-20)37-11-5-10-33-37/h5-14,16H,15H2,1-4H3
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM261983
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3ncc(C)o3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C25H24F2N6O4/c1-13-8-29-21(37-13)12-32-18-6-17(16-11-31(3)30-14(16)2)28-9-15(18)10-33(25(32)34)24-22(26)19(35-4)7-20(36-5)23(24)27/h6-9,11H,10,12H2,1-5H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM261988
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C2=O)c2cncc(C)n2)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C25H23F2N7O3/c1-13-8-28-10-21(30-13)34-18-6-17(16-12-32(3)31-14(16)2)29-9-15(18)11-33(25(34)35)24-22(26)19(36-4)7-20(37-5)23(24)27/h6-10,12H,11H2,1-5H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262000
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C2=O)c2cccc(F)c2)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C26H22F3N5O3/c1-14-18(13-32(2)31-14)19-9-20-15(11-30-19)12-33(26(35)34(20)17-7-5-6-16(27)8-17)25-23(28)21(36-3)10-22(37-4)24(25)29/h5-11,13H,12H2,1-4H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262002
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3cn(C)nc3C)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C26H27F2N7O3/c1-14-17(10-32(3)30-14)12-34-20-7-19(18-13-33(4)31-15(18)2)29-9-16(20)11-35(26(34)36)25-23(27)21(37-5)8-22(38-6)24(25)28/h7-10,13H,11-12H2,1-6H3
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262005
PNG
(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dime...)
Show SMILES COc1ccc(cc1)N1C(=O)N(Cc2cnc(cc12)-c1cn(C)nc1C)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C27H25F2N5O4/c1-15-19(14-32(2)31-15)20-10-21-16(12-30-20)13-33(26-24(28)22(37-4)11-23(38-5)25(26)29)27(35)34(21)17-6-8-18(36-3)9-7-17/h6-12,14H,13H2,1-5H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262019
PNG
(1-((1-cyclopropyl-1H-pyrazol-4-yl)methyl)-3-(2,6-d...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3cnn(c3)C3CC3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C27H27F2N7O3/c1-15-19(14-33(2)32-15)20-7-21-17(10-30-20)13-35(26-24(28)22(38-3)8-23(39-4)25(26)29)27(37)34(21)11-16-9-31-36(12-16)18-5-6-18/h7-10,12,14,18H,5-6,11,13H2,1-4H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM262019
PNG
(1-((1-cyclopropyl-1H-pyrazol-4-yl)methyl)-3-(2,6-d...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(Cc3cnn(c3)C3CC3)C2=O)-c2cn(C)nc2C)c1F
Show InChI InChI=1S/C27H27F2N7O3/c1-15-19(14-33(2)32-15)20-7-21-17(10-30-20)13-35(26-24(28)22(38-3)8-23(39-4)25(26)29)27(37)34(21)11-16-9-31-36(12-16)18-5-6-18/h7-10,12,14,18H,5-6,11,13H2,1-4H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM262029
PNG
(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(1-(1- (...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cnn(c2)C2CCN(C2)S(C)(=O)=O)c1F
Show InChI InChI=1/C26H27F2N5O5S/c1-37-20-9-21(38-2)23(28)24(22(20)27)32-12-15-10-29-19(8-18(15)26(5-6-26)25(32)34)16-11-30-33(13-16)17-4-7-31(14-17)39(3,35)36/h8-11,13,17H,4-7,12,14H2,1-3H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10251892 (2019)

More data for this
Ligand-Target Pair
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