BindingDB logo
myBDB logout

Patent code US10251893

Compile Data Set for Download or QSAR

Found 230 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374996
PNG
(N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(2-fl...)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(NC(=O)Cc2cc(C)c(cc2F)-c2ccnc(C)c2)nc1
Show InChI InChI=1S/C26H28FN5O2/c1-17-12-21(24(27)15-23(17)20-6-7-28-18(2)13-20)14-26(34)30-25-5-4-22(16-29-25)32-10-8-31(9-11-32)19(3)33/h4-7,12-13,15-16H,8-11,14H2,1-3H3,(H,29,30,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0400n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374879
PNG
(US10251893, Cpd 83)
Show SMILES Cc1cc(ccn1)-c1ccc(CC(=O)Nc2ccc(cn2)-c2cccc(F)c2)cn1
Show InChI InChI=1S/C24H19FN4O/c1-16-11-19(9-10-26-16)22-7-5-17(14-27-22)12-24(30)29-23-8-6-20(15-28-23)18-3-2-4-21(25)13-18/h2-11,13-15H,12H2,1H3,(H,28,29,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0600n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374843
PNG
(US10251893, Cpd 47)
Show SMILES Cc1cc(ccn1)-c1ccc(CC(=O)Nc2ccc(cn2)-c2cccnc2)cc1
Show InChI InChI=1S/C24H20N4O/c1-17-13-20(10-12-26-17)19-6-4-18(5-7-19)14-24(29)28-23-9-8-22(16-27-23)21-3-2-11-25-15-21/h2-13,15-16H,14H2,1H3,(H,27,28,29)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0700n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374902
PNG
(US10251893, Cpd 110)
Show SMILES Cc1cc(ccn1)-c1ccc(CC(=O)Nc2ccc(nn2)-c2ccccc2)cn1
Show InChI InChI=1S/C23H19N5O/c1-16-13-19(11-12-24-16)20-8-7-17(15-25-20)14-23(29)26-22-10-9-21(27-28-22)18-5-3-2-4-6-18/h2-13,15H,14H2,1H3,(H,26,28,29)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0800n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374852
PNG
(US10251893, Cpd 56)
Show SMILES Cc1cc(ccn1)-c1ccc(CC(=O)Nc2ccc(cn2)-c2cccc(F)c2)cc1
Show InChI InChI=1S/C25H20FN3O/c1-17-13-21(11-12-27-17)19-7-5-18(6-8-19)14-25(30)29-24-10-9-22(16-28-24)20-3-2-4-23(26)15-20/h2-13,15-16H,14H2,1H3,(H,28,29,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.0900n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM375015
PNG
(N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(3-cy...)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(NC(=O)Cc2ccc(-c3ccnc(F)c3)c(c2)C#N)nc1
Show InChI InChI=1S/C25H23FN6O2/c1-17(33)31-8-10-32(11-9-31)21-3-5-24(29-16-21)30-25(34)13-18-2-4-22(20(12-18)15-27)19-6-7-28-23(26)14-19/h2-7,12,14,16H,8-11,13H2,1H3,(H,29,30,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374871
PNG
(US10251893, Cpd 75)
Show SMILES Cc1cc(ccn1)-c1ccc(CC(=O)Nc2ccc(cn2)-c2ccccn2)cc1C
Show InChI InChI=1S/C25H22N4O/c1-17-13-19(6-8-22(17)20-10-12-26-18(2)14-20)15-25(30)29-24-9-7-21(16-28-24)23-5-3-4-11-27-23/h3-14,16H,15H2,1-2H3,(H,28,29,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374904
PNG
(US10251893, Cpd 112)
Show SMILES FC(F)(F)c1cc(CC(=O)Nc2ccc(cn2)-c2ccccn2)ccc1-c1ccnnc1
Show InChI InChI=1S/C23H16F3N5O/c24-23(25,26)19-11-15(4-6-18(19)16-8-10-29-30-14-16)12-22(32)31-21-7-5-17(13-28-21)20-3-1-2-9-27-20/h1-11,13-14H,12H2,(H,28,31,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374932
PNG
(Methyl 4-(6-(2-(4-(2-methylpyridin-4-yl)phenyl)ace...)
Show SMILES COC(=O)N1CCN(CC1)c1ccc(NC(=O)Cc2ccc(cc2)-c2ccnc(C)c2)nc1
Show InChI InChI=1S/C25H27N5O3/c1-18-15-21(9-10-26-18)20-5-3-19(4-6-20)16-24(31)28-23-8-7-22(17-27-23)29-11-13-30(14-12-29)25(32)33-2/h3-10,15,17H,11-14,16H2,1-2H3,(H,27,28,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374972
PNG
(US10251893, Cpd 170)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(NC(=O)Cc2ccc(c(Cl)c2)-c2ccnc(C)c2)nc1
Show InChI InChI=1S/C25H26ClN5O2/c1-17-13-20(7-8-27-17)22-5-3-19(14-23(22)26)15-25(33)29-24-6-4-21(16-28-24)31-11-9-30(10-12-31)18(2)32/h3-8,13-14,16H,9-12,15H2,1-2H3,(H,28,29,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374974
PNG
(N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(4-(2...)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(NC(=O)Cc2ccc(-c3ccnc(C)c3)c(c2)C(F)(F)F)nc1
Show InChI InChI=1S/C26H26F3N5O2/c1-17-13-20(7-8-30-17)22-5-3-19(14-23(22)26(27,28)29)15-25(36)32-24-6-4-21(16-31-24)34-11-9-33(10-12-34)18(2)35/h3-8,13-14,16H,9-12,15H2,1-2H3,(H,31,32,36)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374988
PNG
(N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(3-ch...)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(NC(=O)Cc2cnc(c(Cl)c2)-c2ccnc(C)c2)nc1
Show InChI InChI=1S/C24H25ClN6O2/c1-16-11-19(5-6-26-16)24-21(25)12-18(14-28-24)13-23(33)29-22-4-3-20(15-27-22)31-9-7-30(8-10-31)17(2)32/h3-6,11-12,14-15H,7-10,13H2,1-2H3,(H,27,29,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374992
PNG
(US10251893, Cpd 187)
Show SMILES CC(C)OC(=O)N1CCN(CC1)c1ccc(NC(=O)Cc2cnc(c(C)c2)-c2ccnc(C)c2)nc1
Show InChI InChI=1S/C27H32N6O3/c1-18(2)36-27(35)33-11-9-32(10-12-33)23-5-6-24(29-17-23)31-25(34)15-21-13-19(3)26(30-16-21)22-7-8-28-20(4)14-22/h5-8,13-14,16-18H,9-12,15H2,1-4H3,(H,29,31,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374870
PNG
(N-(5-(3-fluorophenyl)pyridin-2-yl)-2-(5-methyl-6-(...)
Show SMILES Cc1cc(CC(=O)Nc2ccc(cn2)-c2cccc(F)c2)cnc1-c1ccnnc1
Show InChI InChI=1S/C23H18FN5O/c1-15-9-16(12-26-23(15)19-7-8-27-28-14-19)10-22(30)29-21-6-5-18(13-25-21)17-3-2-4-20(24)11-17/h2-9,11-14H,10H2,1H3,(H,25,29,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374984
PNG
(US10251893, Cpd 180)
Show SMILES Cc1cc(ccn1)-c1ccc(CC(=O)Nc2ccc(nc2)-c2cnccn2)cc1C#N
Show InChI InChI=1S/C24H18N6O/c1-16-10-18(6-7-27-16)21-4-2-17(11-19(21)13-25)12-24(31)30-20-3-5-22(29-14-20)23-15-26-8-9-28-23/h2-11,14-15H,12H2,1H3,(H,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374982
PNG
(N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(4-(2...)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(NC(=O)Cc2ccc(cc2)-c2ccnc(F)c2)nc1
Show InChI InChI=1S/C24H24FN5O2/c1-17(31)29-10-12-30(13-11-29)21-6-7-23(27-16-21)28-24(32)14-18-2-4-19(5-3-18)20-8-9-26-22(25)15-20/h2-9,15-16H,10-14H2,1H3,(H,27,28,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374969
PNG
(US10251893, Cpd 167)
Show SMILES COC(=O)N1CCN(CC1)c1ccc(NC(=O)Cc2ccc(c(C)c2)-c2ccnc(C)c2)nc1
Show InChI InChI=1S/C26H29N5O3/c1-18-14-20(4-6-23(18)21-8-9-27-19(2)15-21)16-25(32)29-24-7-5-22(17-28-24)30-10-12-31(13-11-30)26(33)34-3/h4-9,14-15,17H,10-13,16H2,1-3H3,(H,28,29,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374983
PNG
(US10251893, Cpd 179)
Show SMILES Cc1cc(ccn1)-c1ccc(CC(=O)Nc2ccc(cn2)-c2cnccn2)cc1C#N
Show InChI InChI=1S/C24H18N6O/c1-16-10-18(6-7-27-16)21-4-2-17(11-20(21)13-25)12-24(31)30-23-5-3-19(14-29-23)22-15-26-8-9-28-22/h2-11,14-15H,12H2,1H3,(H,29,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374933
PNG
(US10251893, Cpd 133)
Show SMILES Cc1cc(CC(=O)Nc2ccc(cn2)-c2cnccn2)ccc1-c1ccnnc1
Show InChI InChI=1S/C22H18N6O/c1-15-10-16(2-4-19(15)17-6-7-26-27-13-17)11-22(29)28-21-5-3-18(12-25-21)20-14-23-8-9-24-20/h2-10,12-14H,11H2,1H3,(H,25,28,29)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374968
PNG
(US10251893, Cpd 166)
Show SMILES COC(=O)N1CCN(CC1)c1ccc(NC(=O)Cc2cnc(c(C)c2)-c2ccnc(C)c2)nc1
Show InChI InChI=1S/C25H28N6O3/c1-17-12-19(15-28-24(17)20-6-7-26-18(2)13-20)14-23(32)29-22-5-4-21(16-27-22)30-8-10-31(11-9-30)25(33)34-3/h4-7,12-13,15-16H,8-11,14H2,1-3H3,(H,27,29,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374970
PNG
(N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(3-fl...)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(NC(=O)Cc2ccc(c(F)c2)-c2ccnc(C)c2)nc1
Show InChI InChI=1S/C25H26FN5O2/c1-17-13-20(7-8-27-17)22-5-3-19(14-23(22)26)15-25(33)29-24-6-4-21(16-28-24)31-11-9-30(10-12-31)18(2)32/h3-8,13-14,16H,9-12,15H2,1-2H3,(H,28,29,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374913
PNG
(US10251893, Cpd 121)
Show SMILES Cc1cc(ccn1)-c1ccc(CC(=O)Nc2ccc(cn2)-c2ccccn2)cc1C(F)(F)F
Show InChI InChI=1S/C25H19F3N4O/c1-16-12-18(9-11-29-16)20-7-5-17(13-21(20)25(26,27)28)14-24(33)32-23-8-6-19(15-31-23)22-4-2-3-10-30-22/h2-13,15H,14H2,1H3,(H,31,32,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374910
PNG
(N-(5-(pyrazin-2-yl)pyridin-2-yl)-2-(4-(pyridazin-4...)
Show SMILES FC(F)(F)c1cc(CC(=O)Nc2ccc(cn2)-c2cnccn2)ccc1-c1ccnnc1
Show InChI InChI=1S/C22H15F3N6O/c23-22(24,25)18-9-14(1-3-17(18)15-5-6-29-30-12-15)10-21(32)31-20-4-2-16(11-28-20)19-13-26-7-8-27-19/h1-9,11-13H,10H2,(H,28,31,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374986
PNG
(N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(3-me...)
Show SMILES COc1cc(CC(=O)Nc2ccc(cn2)N2CCN(CC2)C(C)=O)ccc1-c1ccnc(C)c1
Show InChI InChI=1S/C26H29N5O3/c1-18-14-21(8-9-27-18)23-6-4-20(15-24(23)34-3)16-26(33)29-25-7-5-22(17-28-25)31-12-10-30(11-13-31)19(2)32/h4-9,14-15,17H,10-13,16H2,1-3H3,(H,28,29,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374975
PNG
(US10251893, Cpd 173)
Show SMILES Cc1cc(ccn1)-c1ccc(CC(=O)Nc2ccc(nc2)-c2ccccc2)cc1C#N
Show InChI InChI=1S/C26H20N4O/c1-18-13-21(11-12-28-18)24-9-7-19(14-22(24)16-27)15-26(31)30-23-8-10-25(29-17-23)20-5-3-2-4-6-20/h2-14,17H,15H2,1H3,(H,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM375009
PNG
(2-(2',3-difluoro-2,4'-bipyridin-5-yl)-N-(5-(pyrazi...)
Show SMILES Fc1cc(ccn1)-c1ncc(CC(=O)Nc2ccc(cn2)-c2cnccn2)cc1F
Show InChI InChI=1S/C21H14F2N6O/c22-16-7-13(10-28-21(16)14-3-4-26-18(23)9-14)8-20(30)29-19-2-1-15(11-27-19)17-12-24-5-6-25-17/h1-7,9-12H,8H2,(H,27,29,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374998
PNG
(N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(2'-f...)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(NC(=O)Cc2cnc(c(C)c2)-c2ccnc(F)c2)nc1
Show InChI InChI=1S/C24H25FN6O2/c1-16-11-18(14-28-24(16)19-5-6-26-21(25)13-19)12-23(33)29-22-4-3-20(15-27-22)31-9-7-30(8-10-31)17(2)32/h3-6,11,13-15H,7-10,12H2,1-2H3,(H,27,29,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374994
PNG
(N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(2'-m...)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(NC(=O)Cc2cnc(-c3ccnc(C)c3)c(c2)C(F)(F)F)nc1
Show InChI InChI=1S/C25H25F3N6O2/c1-16-11-19(5-6-29-16)24-21(25(26,27)28)12-18(14-31-24)13-23(36)32-22-4-3-20(15-30-22)34-9-7-33(8-10-34)17(2)35/h3-6,11-12,14-15H,7-10,13H2,1-2H3,(H,30,32,36)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374989
PNG
(US10251893, Cpd 185)
Show SMILES C[C@H]1CN(CCN1C(C)=O)c1ccc(NC(=O)Cc2ccc(-c3ccnc(C)c3)c(c2)C#N)nc1
Show InChI InChI=1/C27H28N6O2/c1-18-12-22(8-9-29-18)25-6-4-21(13-23(25)15-28)14-27(35)31-26-7-5-24(16-30-26)32-10-11-33(20(3)34)19(2)17-32/h4-9,12-13,16,19H,10-11,14,17H2,1-3H3,(H,30,31,35)/t19-/s2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374985
PNG
(2-(3-cyano-4-(2-methylpyridin-4-yl)phenyl)-N-(5-(p...)
Show SMILES Cc1cc(ccn1)-c1ccc(CC(=O)Nc2ccc(cn2)-c2cccnn2)cc1C#N
Show InChI InChI=1S/C24H18N6O/c1-16-11-18(8-10-26-16)21-6-4-17(12-20(21)14-25)13-24(31)29-23-7-5-19(15-27-23)22-3-2-9-28-30-22/h2-12,15H,13H2,1H3,(H,27,29,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM375017
PNG
(2-(3-fluoro-4-(2-fluoropyridin-4-yl)phenyl)-N-(5-(...)
Show SMILES Fc1cc(ccn1)-c1ccc(CC(=O)Nc2ccc(cn2)-c2cccnn2)cc1F
Show InChI InChI=1S/C22H15F2N5O/c23-18-10-14(3-5-17(18)15-7-9-25-20(24)12-15)11-22(30)28-21-6-4-16(13-26-21)19-2-1-8-27-29-19/h1-10,12-13H,11H2,(H,26,28,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374912
PNG
(US10251893, Cpd 120)
Show SMILES Fc1cccc(c1)-c1ccc(NC(=O)Cc2ccc(cc2)-c2ccnnc2)nc1
Show InChI InChI=1S/C23H17FN4O/c24-21-3-1-2-18(13-21)19-8-9-22(25-14-19)28-23(29)12-16-4-6-17(7-5-16)20-10-11-26-27-15-20/h1-11,13-15H,12H2,(H,25,28,29)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM50133864
PNG
(CHEMBL2139947 | US10251893, Compound 59)
Show SMILES Cc1cc(ccn1)-c1ccc(CC(=O)Nc2ccc(cc2)-c2cccnc2)cc1
Show InChI InChI=1S/C25H21N3O/c1-18-15-22(12-14-27-18)20-6-4-19(5-7-20)16-25(29)28-24-10-8-21(9-11-24)23-3-2-13-26-17-23/h2-15,17H,16H2,1H3,(H,28,29)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<0.110n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374897
PNG
(US10251893, Cpd 105)
Show SMILES Fc1cccc(c1)-c1ccc(NC(=O)Cc2ccc(-c3ccnnc3)c(c2)C(F)(F)F)cn1
Show InChI InChI=1S/C24H16F4N4O/c25-18-3-1-2-16(12-18)22-7-5-19(14-29-22)32-23(33)11-15-4-6-20(17-8-9-30-31-13-17)21(10-15)24(26,27)28/h1-10,12-14H,11H2,(H,32,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.110n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374903
PNG
(N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(3-cy...)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(NC(=O)Cc2ccc(-c3ccnc(C)c3)c(c2)C#N)nc1
Show InChI InChI=1S/C26H26N6O2/c1-18-13-21(7-8-28-18)24-5-3-20(14-22(24)16-27)15-26(34)30-25-6-4-23(17-29-25)32-11-9-31(10-12-32)19(2)33/h3-8,13-14,17H,9-12,15H2,1-2H3,(H,29,30,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.110n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374832
PNG
(US10251893, Cpd 36)
Show SMILES Cc1cc(ccn1)-c1ccc(CC(=O)Nc2ccc(nc2)-c2ccccc2)cc1
Show InChI InChI=1S/C25H21N3O/c1-18-15-22(13-14-26-18)20-9-7-19(8-10-20)16-25(29)28-23-11-12-24(27-17-23)21-5-3-2-4-6-21/h2-15,17H,16H2,1H3,(H,28,29)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.110n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374872
PNG
(US10251893, Cpd 76)
Show SMILES Cc1cc(CC(=O)Nc2ccc(cn2)-c2ccccn2)ccc1-c1ccnnc1
Show InChI InChI=1S/C23H19N5O/c1-16-12-17(5-7-20(16)18-9-11-26-27-15-18)13-23(29)28-22-8-6-19(14-25-22)21-4-2-3-10-24-21/h2-12,14-15H,13H2,1H3,(H,25,28,29)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.120n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374876
PNG
(US10251893, Cpd 80)
Show SMILES Cc1cc(ccn1)-c1ncc(CC(=O)Nc2ccc(cn2)-c2cccc(F)c2)cc1C
Show InChI InChI=1S/C25H21FN4O/c1-16-10-18(14-29-25(16)20-8-9-27-17(2)11-20)12-24(31)30-23-7-6-21(15-28-23)19-4-3-5-22(26)13-19/h3-11,13-15H,12H2,1-2H3,(H,28,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.130n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374875
PNG
(US10251893, Cpd 79)
Show SMILES Cc1cc(ccn1)-c1ccc(CC(=O)Nc2ccc(cn2)-c2cnccn2)cc1C(F)(F)F
Show InChI InChI=1S/C24H18F3N5O/c1-15-10-17(6-7-29-15)19-4-2-16(11-20(19)24(25,26)27)12-23(33)32-22-5-3-18(13-31-22)21-14-28-8-9-30-21/h2-11,13-14H,12H2,1H3,(H,31,32,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.130n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374845
PNG
(US10251893, Cpd 49)
Show SMILES Cc1cc(ccn1)-c1ccc(CC(=O)Nc2ccc(nn2)-c2ccccc2)cc1
Show InChI InChI=1S/C24H20N4O/c1-17-15-21(13-14-25-17)19-9-7-18(8-10-19)16-24(29)26-23-12-11-22(27-28-23)20-5-3-2-4-6-20/h2-15H,16H2,1H3,(H,26,28,29)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.140n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374847
PNG
(US10251893, Cpd 51)
Show SMILES Cc1cc(ccn1)-c1ccc(CC(=O)Nc2ccc(cn2)-c2ccccc2)cn1
Show InChI InChI=1S/C24H20N4O/c1-17-13-20(11-12-25-17)22-9-7-18(15-26-22)14-24(29)28-23-10-8-21(16-27-23)19-5-3-2-4-6-19/h2-13,15-16H,14H2,1H3,(H,27,28,29)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.140n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374866
PNG
(US10251893, Cpd 70)
Show SMILES Cc1cc(ccn1)-c1ccc(CC(=O)Nc2ccc(cn2)-c2cccnn2)cc1
Show InChI InChI=1S/C23H19N5O/c1-16-13-19(10-12-24-16)18-6-4-17(5-7-18)14-23(29)27-22-9-8-20(15-25-22)21-3-2-11-26-28-21/h2-13,15H,14H2,1H3,(H,25,27,29)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.150n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM375005
PNG
(US10251893, Cpd 200)
Show SMILES Fc1cc(ccn1)-c1ccc(CC(=O)Nc2ccc(cn2)-c2cnccn2)cc1
Show InChI InChI=1S/C22H16FN5O/c23-20-12-17(7-8-26-20)16-3-1-15(2-4-16)11-22(29)28-21-6-5-18(13-27-21)19-14-24-9-10-25-19/h1-10,12-14H,11H2,(H,27,28,29)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM375016
PNG
(2-(3-fluoro-4-(2-fluoropyridin-4-yl)phenyl)-N-(5-(...)
Show SMILES Fc1cc(ccn1)-c1ccc(CC(=O)Nc2ccc(cn2)-c2cnccn2)cc1F
Show InChI InChI=1S/C22H15F2N5O/c23-18-9-14(1-3-17(18)15-5-6-27-20(24)11-15)10-22(30)29-21-4-2-16(12-28-21)19-13-25-7-8-26-19/h1-9,11-13H,10H2,(H,28,29,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374961
PNG
(N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(3-me...)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(NC(=O)Cc2ccc(c(C)c2)-c2ccnc(C)c2)nc1
Show InChI InChI=1S/C26H29N5O2/c1-18-14-21(4-6-24(18)22-8-9-27-19(2)15-22)16-26(33)29-25-7-5-23(17-28-25)31-12-10-30(11-13-31)20(3)32/h4-9,14-15,17H,10-13,16H2,1-3H3,(H,28,29,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374995
PNG
(N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(3-fl...)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(NC(=O)Cc2cnc(c(F)c2)-c2ccnc(C)c2)nc1
Show InChI InChI=1S/C24H25FN6O2/c1-16-11-19(5-6-26-16)24-21(25)12-18(14-28-24)13-23(33)29-22-4-3-20(15-27-22)31-9-7-30(8-10-31)17(2)32/h3-6,11-12,14-15H,7-10,13H2,1-2H3,(H,27,29,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM375011
PNG
(N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(3-fl...)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(NC(=O)Cc2ccc(c(F)c2)-c2ccnc(F)c2)nc1
Show InChI InChI=1S/C24H23F2N5O2/c1-16(32)30-8-10-31(11-9-30)19-3-5-23(28-15-19)29-24(33)13-17-2-4-20(21(25)12-17)18-6-7-27-22(26)14-18/h2-7,12,14-15H,8-11,13H2,1H3,(H,28,29,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM375018
PNG
(2-(3-cyano-4-(2-fluoropyridin-4-yl)phenyl)-N-(5-(p...)
Show SMILES Fc1cc(ccn1)-c1ccc(CC(=O)Nc2ccc(cn2)-c2cccnn2)cc1C#N
Show InChI InChI=1S/C23H15FN6O/c24-21-12-16(7-9-26-21)19-5-3-15(10-18(19)13-25)11-23(31)29-22-6-4-17(14-27-22)20-2-1-8-28-30-20/h1-10,12,14H,11H2,(H,27,29,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374880
PNG
(US10251893, Cpd 108 | US10251893, Cpd 84)
Show SMILES Cc1cc(ccn1)-c1ccc(CC(=O)Nc2ccc(nc2)-c2cccc(F)c2)cn1
Show InChI InChI=1S/C24H19FN4O/c1-16-11-19(9-10-26-16)22-7-5-17(14-27-22)12-24(30)29-21-6-8-23(28-15-21)18-3-2-4-20(25)13-18/h2-11,13-15H,12H2,1H3,(H,29,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Homo sapiens (Human))
BDBM374914
PNG
(US10251893, Cpd 122)
Show SMILES FC(F)(F)c1cc(CC(=O)Nc2ccc(cn2)-c2cccnn2)ccc1-c1ccnnc1
Show InChI InChI=1S/C22H15F3N6O/c23-22(24,25)18-10-14(3-5-17(18)15-7-9-27-29-13-15)11-21(32)30-20-6-4-16(12-26-20)19-2-1-8-28-31-19/h1-10,12-13H,11H2,(H,26,30,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...


US Patent US10251893 (2019)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 230 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%