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Patent code US10253018

Compile Data Set for Download or QSAR
Found 41 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375253
PNG
(US10253018, Example 19)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2cc3cc(Br)ccc3cn2)n1
Show InChI InChI=1S/C20H17BrN6O/c1-12(2)27-11-23-26-19(27)16-4-3-5-18(24-16)25-20(28)17-9-14-8-15(21)7-6-13(14)10-22-17/h3-12H,1-2H3,(H,24,25,28)
PDB

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US Patent
n/an/a 5.5n/an/an/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375256
PNG
(US10253018, Example 22)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2cc3cc(ccc3cn2)-n2cnc(c2)C2CC2)n1
Show InChI InChI=1S/C26H24N8O/c1-16(2)34-15-29-32-25(34)21-4-3-5-24(30-21)31-26(35)22-11-19-10-20(9-8-18(19)12-27-22)33-13-23(28-14-33)17-6-7-17/h3-5,8-17H,6-7H2,1-2H3,(H,30,31,35)
PDB

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n/an/a 5.5n/an/an/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375252
PNG
(US10253018, Example 18)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2cc3ccccc3cn2)n1
Show InChI InChI=1S/C20H18N6O/c1-13(2)26-12-22-25-19(26)16-8-5-9-18(23-16)24-20(27)17-10-14-6-3-4-7-15(14)11-21-17/h3-13H,1-2H3,(H,23,24,27)
PDB

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n/an/a 5.5n/an/an/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375255
PNG
(US10253018, Example 21)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2cc3cc(ccc3cn2)N2CCCCC2)n1
Show InChI InChI=1S/C25H27N7O/c1-17(2)32-16-27-30-24(32)21-7-6-8-23(28-21)29-25(33)22-14-19-13-20(10-9-18(19)15-26-22)31-11-4-3-5-12-31/h6-10,13-17H,3-5,11-12H2,1-2H3,(H,28,29,33)
PDB

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US Patent
n/an/a 5.5n/an/an/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375272
PNG
(US10253018, Example 38)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2ccc3cc(cnc3c2)N2CCOCC2)n1
Show InChI InChI=1S/C24H25N7O2/c1-16(2)31-15-26-29-23(31)20-4-3-5-22(27-20)28-24(32)18-7-6-17-12-19(14-25-21(17)13-18)30-8-10-33-11-9-30/h3-7,12-16H,8-11H2,1-2H3,(H,27,28,32)
PDB

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n/an/a 55n/an/an/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375257
PNG
(US10253018, Example 23)
Show SMILES CCn1nccc1-c1ccc2cnc(cc2c1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C25H24N8O/c1-4-33-22(10-11-28-33)17-8-9-18-14-26-21(13-19(18)12-17)25(34)30-23-7-5-6-20(29-23)24-31-27-15-32(24)16(2)3/h5-16H,4H2,1-3H3,(H,29,30,34)
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n/an/a 55n/an/an/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375267
PNG
(US10253018, Example 33)
Show SMILES COCCNc1ccc2ccc(cc2n1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C23H25N7O2/c1-15(2)30-14-25-29-22(30)18-5-4-6-21(26-18)28-23(31)17-8-7-16-9-10-20(24-11-12-32-3)27-19(16)13-17/h4-10,13-15H,11-12H2,1-3H3,(H,24,27)(H,26,28,31)
PDB

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n/an/a 55n/an/an/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375260
PNG
(US10253018, Example 26)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2ccc3ccc(nc3c2)N2CCCCC2)n1
Show InChI InChI=1S/C25H27N7O/c1-17(2)32-16-26-30-24(32)20-7-6-8-22(27-20)29-25(33)19-10-9-18-11-12-23(28-21(18)15-19)31-13-4-3-5-14-31/h6-12,15-17H,3-5,13-14H2,1-2H3,(H,27,29,33)
PDB

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n/an/a 55n/an/an/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375249
PNG
(US10253018, Example 15)
Show SMILES CC(C)Nc1nc2cc(C(=O)Nc3cccc(n3)-c3nncn3C(C)C)c(F)cc2nc1OC(C)C
Show InChI InChI=1S/C25H29FN8O2/c1-13(2)28-22-25(36-15(5)6)31-20-11-17(26)16(10-19(20)30-22)24(35)32-21-9-7-8-18(29-21)23-33-27-12-34(23)14(3)4/h7-15H,1-6H3,(H,28,30)(H,29,32,35)
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n/an/a 55n/an/an/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375237
PNG
(US10253018, Example 3)
Show SMILES COc1nc2cc(F)c(cc2nc1N1CCCCC1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C25H27FN8O2/c1-15(2)34-14-27-32-22(34)18-8-7-9-21(28-18)31-24(35)16-12-19-20(13-17(16)26)30-25(36-3)23(29-19)33-10-5-4-6-11-33/h7-9,12-15H,4-6,10-11H2,1-3H3,(H,28,31,35)
PDB

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n/an/a 55n/an/an/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375266
PNG
(US10253018, Example 32)
Show SMILES COCCC[C@@H]1CCCN1c1ccc2ccc(cc2n1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1/C28H33N7O2/c1-19(2)35-18-29-33-27(35)23-9-4-10-25(30-23)32-28(36)21-12-11-20-13-14-26(31-24(20)17-21)34-15-5-7-22(34)8-6-16-37-3/h4,9-14,17-19,22H,5-8,15-16H2,1-3H3,(H,30,32,36)/t22-/s2
PDB

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n/an/a 55n/an/an/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375238
PNG
(US10253018, Example 4)
Show SMILES CC(C)Nc1nc2cc(ccc2nc1OC(C)C)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C25H30N8O2/c1-14(2)27-22-25(35-16(5)6)30-18-11-10-17(12-20(18)29-22)24(34)31-21-9-7-8-19(28-21)23-32-26-13-33(23)15(3)4/h7-16H,1-6H3,(H,27,29)(H,28,31,34)
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n/an/a 55n/an/an/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375268
PNG
(US10253018, Example 34)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2ccc3ccc(Cl)nc3c2)n1
Show InChI InChI=1S/C20H17ClN6O/c1-12(2)27-11-22-26-19(27)15-4-3-5-18(24-15)25-20(28)14-7-6-13-8-9-17(21)23-16(13)10-14/h3-12H,1-2H3,(H,24,25,28)
PDB

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n/an/a 550n/an/an/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375273
PNG
(US10253018, Example 39)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2ccc3ccccc3c2)n1
Show InChI InChI=1S/C21H19N5O/c1-14(2)26-13-22-25-20(26)18-8-5-9-19(23-18)24-21(27)17-11-10-15-6-3-4-7-16(15)12-17/h3-14H,1-2H3,(H,23,24,27)
PDB

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n/an/a 550n/an/an/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375264
PNG
(US10253018, Example 30)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2ccc3ccc(nc3c2)N2CC3CCC(C2)O3)n1
Show InChI InChI=1/C26H27N7O2/c1-16(2)33-15-27-31-25(33)21-4-3-5-23(28-21)30-26(34)18-7-6-17-8-11-24(29-22(17)12-18)32-13-19-9-10-20(14-32)35-19/h3-8,11-12,15-16,19-20H,9-10,13-14H2,1-2H3,(H,28,30,34)
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n/an/a 550n/an/an/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375245
PNG
(US10253018, Example 11)
Show SMILES CC(C)Oc1nc2cc(F)c(cc2nc1OC(C)C)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C25H28FN7O3/c1-13(2)33-12-27-32-22(33)18-8-7-9-21(28-18)31-23(34)16-10-19-20(11-17(16)26)30-25(36-15(5)6)24(29-19)35-14(3)4/h7-15H,1-6H3,(H,28,31,34)
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n/an/a 550n/an/an/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375235
PNG
(US10253018, Example 1)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2ccc3nccnc3c2)n1
Show InChI InChI=1S/C19H17N7O/c1-12(2)26-11-22-25-18(26)15-4-3-5-17(23-15)24-19(27)13-6-7-14-16(10-13)21-9-8-20-14/h3-12H,1-2H3,(H,23,24,27)
PDB

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n/an/a 550n/an/an/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375258
PNG
(US10253018, Example 24)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2ccc3ccc(nc3c2)N2CCOCC2)n1
Show InChI InChI=1S/C24H25N7O2/c1-16(2)31-15-25-29-23(31)19-4-3-5-21(26-19)28-24(32)18-7-6-17-8-9-22(27-20(17)14-18)30-10-12-33-13-11-30/h3-9,14-16H,10-13H2,1-2H3,(H,26,28,32)
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n/an/a 550n/an/an/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375250
PNG
(US10253018, Example 16)
Show SMILES COc1nc2cc(F)c(cc2nc1N1CCCCC1)C(=O)Nc1cccc(n1)-c1nnnn1C(C)C
Show InChI InChI=1S/C24H26FN9O2/c1-14(2)34-21(30-31-32-34)17-8-7-9-20(26-17)29-23(35)15-12-18-19(13-16(15)25)28-24(36-3)22(27-18)33-10-5-4-6-11-33/h7-9,12-14H,4-6,10-11H2,1-3H3,(H,26,29,35)
PDB

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n/an/a 550n/an/an/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375274
PNG
(US10253018, Example 40)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2cc3ccccc3cc2F)n1
Show InChI InChI=1S/C21H18FN5O/c1-13(2)27-12-23-26-20(27)18-8-5-9-19(24-18)25-21(28)16-10-14-6-3-4-7-15(14)11-17(16)22/h3-13H,1-2H3,(H,24,25,28)
PDB

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n/an/a 550n/an/an/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375270
PNG
(US10253018, Example 36)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2ccc3cc(Br)cnc3c2)n1
Show InChI InChI=1S/C20H17BrN6O/c1-12(2)27-11-23-26-19(27)16-4-3-5-18(24-16)25-20(28)14-7-6-13-8-15(21)10-22-17(13)9-14/h3-12H,1-2H3,(H,24,25,28)
PDB

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n/an/a 550n/an/an/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375242
PNG
(US10253018, Example 8)
Show SMILES COc1nc2ccc(cc2nc1NC(C)C)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C23H26N8O2/c1-13(2)25-20-23(33-5)28-16-10-9-15(11-18(16)27-20)22(32)29-19-8-6-7-17(26-19)21-30-24-12-31(21)14(3)4/h6-14H,1-5H3,(H,25,27)(H,26,29,32)
PDB

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n/an/a 550n/an/an/an/an/an/a



ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375241
PNG
(US10253018, Example 7)
Show SMILES CC(C)Oc1nc2ccc(cc2nc1N1CCOCC1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C26H30N8O3/c1-16(2)34-15-27-32-23(34)20-6-5-7-22(28-20)31-25(35)18-8-9-19-21(14-18)29-24(26(30-19)37-17(3)4)33-10-12-36-13-11-33/h5-9,14-17H,10-13H2,1-4H3,(H,28,31,35)
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ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375247
PNG
(US10253018, Example 13)
Show SMILES CC(C)CN(C)c1nc2cc(C(=O)Nc3cccc(n3)-c3nncn3C(C)C)c(F)cc2nc1OC(C)C
Show InChI InChI=1S/C27H33FN8O2/c1-15(2)13-35(7)25-27(38-17(5)6)32-22-12-19(28)18(11-21(22)31-25)26(37)33-23-10-8-9-20(30-23)24-34-29-14-36(24)16(3)4/h8-12,14-17H,13H2,1-7H3,(H,30,33,37)
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ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375239
PNG
(US10253018, Example 5)
Show SMILES COc1nc2ccc(cc2nc1N1CCCCC1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C25H28N8O2/c1-16(2)33-15-26-31-22(33)19-8-7-9-21(27-19)30-24(34)17-10-11-18-20(14-17)28-23(25(29-18)35-3)32-12-5-4-6-13-32/h7-11,14-16H,4-6,12-13H2,1-3H3,(H,27,30,34)
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ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375236
PNG
(US10253018, Example 2)
Show SMILES COc1nc2ccc(cc2nc1N1CCOCC1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C24H26N8O3/c1-15(2)32-14-25-30-21(32)18-5-4-6-20(26-18)29-23(33)16-7-8-17-19(13-16)27-22(24(28-17)34-3)31-9-11-35-12-10-31/h4-8,13-15H,9-12H2,1-3H3,(H,26,29,33)
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ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375265
PNG
(US10253018, Example 31)
Show SMILES CCN(Cc1ccccc1)c1ccc2ccc(cc2n1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C29H29N7O/c1-4-35(18-21-9-6-5-7-10-21)27-16-15-22-13-14-23(17-25(22)32-27)29(37)33-26-12-8-11-24(31-26)28-34-30-19-36(28)20(2)3/h5-17,19-20H,4,18H2,1-3H3,(H,31,33,37)
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ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375261
PNG
(US10253018, Example 27)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2ccc3ccc(nc3c2)N2CCN(CC2)C(C)(C)C)n1
Show InChI InChI=1S/C28H34N8O/c1-19(2)36-18-29-33-26(36)22-7-6-8-24(30-22)32-27(37)21-10-9-20-11-12-25(31-23(20)17-21)34-13-15-35(16-14-34)28(3,4)5/h6-12,17-19H,13-16H2,1-5H3,(H,30,32,37)
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ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375246
PNG
(US10253018, Example 12)
Show SMILES CC(C)CN(C)c1nc2cc(C(=O)Nc3cccc(n3)-c3nnnn3C(C)C)c(F)cc2nc1OC(C)C
Show InChI InChI=1S/C26H32FN9O2/c1-14(2)13-35(7)24-26(38-16(5)6)30-21-12-18(27)17(11-20(21)29-24)25(37)31-22-10-8-9-19(28-22)23-32-33-34-36(23)15(3)4/h8-12,14-16H,13H2,1-7H3,(H,28,31,37)
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ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375271
PNG
(US10253018, Example 37)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2ccc3cc(cnc3c2)-c2ccc(cc2)C(C)(C)C)n1
Show InChI InChI=1S/C30H30N6O/c1-19(2)36-18-32-35-28(36)25-7-6-8-27(33-25)34-29(37)22-10-9-21-15-23(17-31-26(21)16-22)20-11-13-24(14-12-20)30(3,4)5/h6-19H,1-5H3,(H,33,34,37)
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ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375263
PNG
(US10253018, Example 29)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2ccc3ccc(nc3c2)N2CC3(COC3)C2)n1
Show InChI InChI=1S/C25H25N7O2/c1-16(2)32-15-26-30-23(32)19-4-3-5-21(27-19)29-24(33)18-7-6-17-8-9-22(28-20(17)10-18)31-11-25(12-31)13-34-14-25/h3-10,15-16H,11-14H2,1-2H3,(H,27,29,33)
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ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375262
PNG
(US10253018, Example 28)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2ccc3ccc(NC4CCCCC4)nc3c2)n1
Show InChI InChI=1S/C26H29N7O/c1-17(2)33-16-27-32-25(33)21-9-6-10-23(29-21)31-26(34)19-12-11-18-13-14-24(30-22(18)15-19)28-20-7-4-3-5-8-20/h6,9-17,20H,3-5,7-8H2,1-2H3,(H,28,30)(H,29,31,34)
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ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375254
PNG
(US10253018, Example 20)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3cc(Br)ccc3cn2)n1
Show InChI InChI=1S/C19H16BrN7O/c1-11(2)27-18(24-25-26-27)15-4-3-5-17(22-15)23-19(28)16-9-13-8-14(20)7-6-12(13)10-21-16/h3-11H,1-2H3,(H,22,23,28)
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ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375275
PNG
(US10253018, Example 41B)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc3ccccc3cc2F)n1
Show InChI InChI=1S/C20H17FN6O/c1-12(2)27-19(24-25-26-27)17-8-5-9-18(22-17)23-20(28)15-10-13-6-3-4-7-14(13)11-16(15)21/h3-12H,1-2H3,(H,22,23,28)
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ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375269
PNG
(US10253018, Example 35)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2ccc3cccnc3c2)n1
Show InChI InChI=1S/C20H18N6O/c1-13(2)26-12-22-25-19(26)16-6-3-7-18(23-16)24-20(27)15-9-8-14-5-4-10-21-17(14)11-15/h3-13H,1-2H3,(H,23,24,27)
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ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375259
PNG
(US10253018, Example 25)
Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2ccc3ccc(nc3c2)N(C)C)n1
Show InChI InChI=1S/C22H23N7O/c1-14(2)29-13-23-27-21(29)17-6-5-7-19(24-17)26-22(30)16-9-8-15-10-11-20(28(3)4)25-18(15)12-16/h5-14H,1-4H3,(H,24,26,30)
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ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375244
PNG
(US10253018, Example 10)
Show SMILES CC(C)Oc1nc2cc(F)c(cc2nc1OC(C)C)C(=O)Nc1cccc(n1)-c1nnnn1C(C)C
Show InChI InChI=1S/C24H27FN8O3/c1-12(2)33-21(30-31-32-33)17-8-7-9-20(26-17)29-22(34)15-10-18-19(11-16(15)25)28-24(36-14(5)6)23(27-18)35-13(3)4/h7-14H,1-6H3,(H,26,29,34)
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ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375251
PNG
(US10253018, Example 17)
Show SMILES CC(C)Nc1nc2cc(C(=O)Nc3cccc(n3)-c3nnnn3[C@@H](C)CO)c(F)cc2nc1OC(C)C
Show InChI InChI=1/C24H28FN9O3/c1-12(2)26-21-24(37-13(3)4)29-19-10-16(25)15(9-18(19)28-21)23(36)30-20-8-6-7-17(27-20)22-31-32-33-34(22)14(5)11-35/h6-10,12-14,35H,11H2,1-5H3,(H,26,28)(H,27,30,36)/t14-/s2
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ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375248
PNG
(US10253018, Example 14)
Show SMILES CC(C)Nc1nc2cc(C(=O)Nc3cccc(n3)-c3nnnn3C(C)C)c(F)cc2nc1OC(C)C
Show InChI InChI=1S/C24H28FN9O2/c1-12(2)26-21-24(36-14(5)6)29-19-11-16(25)15(10-18(19)28-21)23(35)30-20-9-7-8-17(27-20)22-31-32-33-34(22)13(3)4/h7-14H,1-6H3,(H,26,28)(H,27,30,35)
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ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375240
PNG
(US10253018, Example 6)
Show SMILES CC(C)Oc1nc2ccc(cc2nc1N1CCCCC1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C27H32N8O2/c1-17(2)35-16-28-33-24(35)21-9-8-10-23(29-21)32-26(36)19-11-12-20-22(15-19)30-25(27(31-20)37-18(3)4)34-13-6-5-7-14-34/h8-12,15-18H,5-7,13-14H2,1-4H3,(H,29,32,36)
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ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM375243
PNG
(US10253018, Example 9)
Show SMILES CC(C)Oc1nc2cc(F)c(cc2nc1N(C)C(C)C)C(=O)Nc1cccc(n1)-c1nnnn1C(C)C
Show InChI InChI=1S/C25H30FN9O2/c1-13(2)34(7)23-25(37-15(5)6)29-20-12-17(26)16(11-19(20)28-23)24(36)30-21-10-8-9-18(27-21)22-31-32-33-35(22)14(3)4/h8-15H,1-7H3,(H,27,30,36)
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ENANTA PHARMACEUTICALS, INC.

US Patent


Assay Description
ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...


US Patent US10253018 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%