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Patent code US10259818

Compile Data Set for Download or QSAR
Found 114 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377022
PNG
(US10259818, Example 4)
Show SMILES CC(c1cc(Cl)c(C)c2CN(CCOc12)C1CN(C1)C(C)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H28ClN7O2/c1-12-18-10-29(16-8-30(9-16)15(4)32)5-6-33-21(18)17(7-19(12)24)14(3)31-23-20(13(2)28-31)22(25)26-11-27-23/h7,11,14,16H,5-6,8-10H2,1-4H3,(H2,25,26,27)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377033
PNG
(US10259818, Example 15)
Show SMILES CC(c1cc(Cl)c(C)c2CN(CCOc12)C(=O)Nc1ccccc1C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C26H28ClN7O2/c1-14-7-5-6-8-21(14)31-26(35)33-9-10-36-23-18(11-20(27)15(2)19(23)12-33)17(4)34-25-22(16(3)32-34)24(28)29-13-30-25/h5-8,11,13,17H,9-10,12H2,1-4H3,(H,31,35)(H2,28,29,30)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377044
PNG
(US10259818, Example 26)
Show SMILES C[C@H](c1cc(Cl)c(F)c2CN(CC(C)Oc12)C1CN(C1)C(=O)OC(C)(C)C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C26H33ClFN7O3/c1-13-8-33(16-9-34(10-16)25(36)38-26(4,5)6)11-18-21(28)19(27)7-17(22(18)37-13)15(3)35-24-20(14(2)32-35)23(29)30-12-31-24/h7,12-13,15-16H,8-11H2,1-6H3,(H2,29,30,31)/t13?,15-/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377052
PNG
(US10259818, Example 34)
Show SMILES CC(c1cc(Cl)c(F)c2CN(CCOc12)C1CN(C1)C(C)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H25ClFN7O2/c1-11-18-21(25)26-10-27-22(18)31(28-11)12(2)15-6-17(23)19(24)16-9-29(4-5-33-20(15)16)14-7-30(8-14)13(3)32/h6,10,12,14H,4-5,7-9H2,1-3H3,(H2,25,26,27)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377061
PNG
(US10259818, Example 43)
Show SMILES CC(c1cc(Cl)c(F)c2CN(C[C@H](C)Oc12)C1CC(C1)C(N)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H27ClFN7O2/c1-10-7-31(14-4-13(5-14)22(27)33)8-16-19(25)17(24)6-15(20(16)34-10)12(3)32-23-18(11(2)30-32)21(26)28-9-29-23/h6,9-10,12-14H,4-5,7-8H2,1-3H3,(H2,27,33)(H2,26,28,29)/t10-,12?,13?,14?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377068
PNG
(US10259818, Example 50 | US10259818, Example 52)
Show SMILES CC(c1cc(Cl)c(C#N)c2CN(C[C@H](C)Oc12)C1CN(CC(N)=O)C1)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H28ClN9O2/c1-12-6-33(15-7-32(8-15)10-20(27)35)9-18-17(5-26)19(25)4-16(22(18)36-12)14(3)34-24-21(13(2)31-34)23(28)29-11-30-24/h4,11-12,14-15H,6-10H2,1-3H3,(H2,27,35)(H2,28,29,30)/t12-,14?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377075
PNG
(US10259818, Example 104 | US10259818, Example 57)
Show SMILES CC(c1cc(Cl)c(C#N)c2CN(C[C@@H](C)Oc12)C1CN(CCO)C1)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H29ClN8O2/c1-13-8-32(16-9-31(10-16)4-5-34)11-19-18(7-26)20(25)6-17(22(19)35-13)15(3)33-24-21(14(2)30-33)23(27)28-12-29-24/h6,12-13,15-16,34H,4-5,8-11H2,1-3H3,(H2,27,28,29)/t13-,15?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377084
PNG
(US10259818, Example 66)
Show SMILES CC(c1cc(Cl)c(C#N)c2CN(CC(C)(C)O)C[C@@H](C)Oc12)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H28ClN7O2/c1-12-8-30(10-23(4,5)32)9-17-16(7-25)18(24)6-15(20(17)33-12)14(3)31-22-19(13(2)29-31)21(26)27-11-28-22/h6,11-12,14,32H,8-10H2,1-5H3,(H2,26,27,28)/t12-,14?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377106
PNG
(2-{3-[(2S)-9-[1-(4-amino- 3-methyl-1H-pyrazolo[3,4...)
Show SMILES CC(c1cc(Cl)c(F)c2CN(C[C@@H](C)Oc12)C1CN(CC(N)=O)C1)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H28ClFN8O2/c1-11-5-32(14-6-31(7-14)9-18(26)34)8-16-20(25)17(24)4-15(21(16)35-11)13(3)33-23-19(12(2)30-33)22(27)28-10-29-23/h4,10-11,13-14H,5-9H2,1-3H3,(H2,26,34)(H2,27,28,29)/t11-,13?/m1/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377127
PNG
(2-[9-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyri...)
Show SMILES CC(c1cc(Cl)c(C#N)c2CN(CC(N)=O)C[C@@H](C)Oc12)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H23ClN8O2/c1-10-6-29(8-17(24)31)7-15-14(5-23)16(22)4-13(19(15)32-10)12(3)30-21-18(11(2)28-30)20(25)26-9-27-21/h4,9-10,12H,6-8H2,1-3H3,(H2,24,31)(H2,25,26,27)/t10-,12?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377130
PNG
(9-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyrimid...)
Show SMILES COCCN1C[C@@H](C)Oc2c(cc(Cl)c(C#N)c2C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H26ClN7O2/c1-12-9-29(5-6-31-4)10-17-16(8-24)18(23)7-15(20(17)32-12)14(3)30-22-19(13(2)28-30)21(25)26-11-27-22/h7,11-12,14H,5-6,9-10H2,1-4H3,(H2,25,26,27)/t12-,14?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377035
PNG
(US10259818, Example 17)
Show SMILES CC(c1cc(Cl)c(C)c2CN(CCOc12)S(=O)(=O)c1c(C)noc1C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H26ClN7O4S/c1-11-17-9-30(36(32,33)21-13(3)29-35-15(21)5)6-7-34-20(17)16(8-18(11)24)14(4)31-23-19(12(2)28-31)22(25)26-10-27-23/h8,10,14H,6-7,9H2,1-5H3,(H2,25,26,27)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377038
PNG
(US10259818, Example 20)
Show SMILES CCC(=O)N1CCOc2c(C1)c(C)c(Cl)cc2C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H25ClN6O2/c1-5-17(29)27-6-7-30-19-14(8-16(22)11(2)15(19)9-27)13(4)28-21-18(12(3)26-28)20(23)24-10-25-21/h8,10,13H,5-7,9H2,1-4H3,(H2,23,24,25)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377059
PNG
(US10259818, Example 41)
Show SMILES CC(c1cc(Cl)c(F)c2CN(C[C@H](C)Oc12)C1CC(C1)C(O)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H26ClFN6O3/c1-10-7-30(14-4-13(5-14)23(32)33)8-16-19(25)17(24)6-15(20(16)34-10)12(3)31-22-18(11(2)29-31)21(26)27-9-28-22/h6,9-10,12-14H,4-5,7-8H2,1-3H3,(H,32,33)(H2,26,27,28)/t10-,12?,13?,14?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377060
PNG
(US10259818, Example 42)
Show SMILES CC(c1cc(Cl)c(F)c2CN(C[C@@H](C)Oc12)C1CC(C1)C(O)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H26ClFN6O3/c1-10-7-30(14-4-13(5-14)23(32)33)8-16-19(25)17(24)6-15(20(16)34-10)12(3)31-22-18(11(2)29-31)21(26)27-9-28-22/h6,9-10,12-14H,4-5,7-8H2,1-3H3,(H,32,33)(H2,26,27,28)/t10-,12?,13?,14?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377069
PNG
(US10259818, Example 51 | US10259818, Example 53)
Show SMILES CC(c1cc(Cl)c(C#N)c2CN(C[C@@H](C)Oc12)C1CN(CC(N)=O)C1)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H28ClN9O2/c1-12-6-33(15-7-32(8-15)10-20(27)35)9-18-17(5-26)19(25)4-16(22(18)36-12)14(3)34-24-21(13(2)31-34)23(28)29-11-30-24/h4,11-12,14-15H,6-10H2,1-3H3,(H2,27,35)(H2,28,29,30)/t12-,14?/s2
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377080
PNG
(US10259818, Example 62)
Show SMILES C[C@@H](c1cc(Cl)c(C#N)c2CN(CCO)C[C@@H](C)Oc12)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H24ClN7O2/c1-11-8-28(4-5-30)9-16-15(7-23)17(22)6-14(19(16)31-11)13(3)29-21-18(12(2)27-29)20(24)25-10-26-21/h6,10-11,13,30H,4-5,8-9H2,1-3H3,(H2,24,25,26)/t11-,13+/s2
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377085
PNG
(US10259818, Example 67)
Show SMILES CC(c1cc(Cl)c(C#N)c2CN(C[C@H](C)Oc12)C1CC(C1)NC(C)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C25H29ClN8O2/c1-12-9-33(17-5-16(6-17)31-15(4)35)10-20-19(8-27)21(26)7-18(23(20)36-12)14(3)34-25-22(13(2)32-34)24(28)29-11-30-25/h7,11-12,14,16-17H,5-6,9-10H2,1-4H3,(H,31,35)(H2,28,29,30)/t12-,14?,16?,17?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377092
PNG
(1-(1-{7-chloro-6-fluoro-2- methyl-4-[1- (methylsul...)
Show SMILES CC(c1cc(Cl)c(F)c2CN(CC(C)Oc12)C1CN(C1)S(C)(=O)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H27ClFN7O3S/c1-11-6-29(14-7-30(8-14)35(4,32)33)9-16-19(24)17(23)5-15(20(16)34-11)13(3)31-22-18(12(2)28-31)21(25)26-10-27-22/h5,10-11,13-14H,6-9H2,1-4H3,(H2,25,26,27)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377097
PNG
(US10259818, Example 80 | methyl 3-[9-[1-(4-amino-3...)
Show SMILES COC(=O)N1CC(C1)N1C[C@@H](C)Oc2c(cc(Cl)c(F)c2C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H27ClFN7O3/c1-11-6-30(14-7-31(8-14)23(33)34-4)9-16-19(25)17(24)5-15(20(16)35-11)13(3)32-22-18(12(2)29-32)21(26)27-10-28-22/h5,10-11,13-14H,6-9H2,1-4H3,(H2,26,27,28)/t11-,13?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377101
PNG
(3-[9-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyri...)
Show SMILES CC(c1cc(Cl)c(F)c2CN(C[C@@H](C)Oc12)C1CN(C1)C(N)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H26ClFN8O2/c1-10-5-30(13-6-31(7-13)22(26)33)8-15-18(24)16(23)4-14(19(15)34-10)12(3)32-21-17(11(2)29-32)20(25)27-9-28-21/h4,9-10,12-13H,5-8H2,1-3H3,(H2,26,33)(H2,25,27,28)/t10-,12?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377102
PNG
(3-[9-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyri...)
Show SMILES CC(c1cc(Cl)c(F)c2CN(C[C@H](C)Oc12)C1CN(C1)C(N)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H26ClFN8O2/c1-10-5-30(13-6-31(7-13)22(26)33)8-15-18(24)16(23)4-14(19(15)34-10)12(3)32-21-17(11(2)29-32)20(25)27-9-28-21/h4,9-10,12-13H,5-8H2,1-3H3,(H2,26,33)(H2,25,27,28)/t10-,12?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377026
PNG
(US10259818, Example 8)
Show SMILES COC1CCC(CC1)N1CCOc2c(C1)c(C)c(Cl)cc2C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C25H33ClN6O2/c1-14-20-12-31(17-5-7-18(33-4)8-6-17)9-10-34-23(20)19(11-21(14)26)16(3)32-25-22(15(2)30-32)24(27)28-13-29-25/h11,13,16-18H,5-10,12H2,1-4H3,(H2,27,28,29)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377050
PNG
(US10259818, Example 32)
Show SMILES C[C@H](c1cc(Cl)c(F)c2CN(C[C@H](C)Oc12)C1CN(C1)C(C)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H27ClFN7O2/c1-11-6-31(15-7-30(8-15)14(4)33)9-17-20(25)18(24)5-16(21(17)34-11)13(3)32-23-19(12(2)29-32)22(26)27-10-28-23/h5,10-11,13,15H,6-9H2,1-4H3,(H2,26,27,28)/t11-,13+/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377068
PNG
(US10259818, Example 50 | US10259818, Example 52)
Show SMILES CC(c1cc(Cl)c(C#N)c2CN(C[C@H](C)Oc12)C1CN(CC(N)=O)C1)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H28ClN9O2/c1-12-6-33(15-7-32(8-15)10-20(27)35)9-18-17(5-26)19(25)4-16(22(18)36-12)14(3)34-24-21(13(2)31-34)23(28)29-11-30-24/h4,11-12,14-15H,6-10H2,1-3H3,(H2,27,35)(H2,28,29,30)/t12-,14?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377073
PNG
(US10259818, Example 55)
Show SMILES CC(c1cc(Cl)c(C#N)c2CN(C[C@@H](C)Oc12)C1CN(CC(C)(C)O)C1)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C26H33ClN8O2/c1-14-8-34(17-9-33(10-17)12-26(4,5)36)11-20-19(7-28)21(27)6-18(23(20)37-14)16(3)35-25-22(15(2)32-35)24(29)30-13-31-25/h6,13-14,16-17,36H,8-12H2,1-5H3,(H2,29,30,31)/t14-,16?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377086
PNG
(US10259818, Example 68)
Show SMILES CC(c1cc(Cl)c(C#N)c2CN(C[C@@H](C)Oc12)C1CC(C1)NC(C)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C25H29ClN8O2/c1-12-9-33(17-5-16(6-17)31-15(4)35)10-20-19(8-27)21(26)7-18(23(20)36-12)14(3)34-25-22(13(2)32-34)24(28)29-11-30-25/h7,11-12,14,16-17H,5-6,9-10H2,1-4H3,(H,31,35)(H2,28,29,30)/t12-,14?,16?,17?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377088
PNG
(US10259818, Example 70)
Show SMILES CC[C@@H]1CN(CCO)Cc2c(O1)c(cc(Cl)c2C#N)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H26ClN7O2/c1-4-14-9-29(5-6-31)10-17-16(8-24)18(23)7-15(20(17)32-14)13(3)30-22-19(12(2)28-30)21(25)26-11-27-22/h7,11,13-14,31H,4-6,9-10H2,1-3H3,(H2,25,26,27)/t13?,14-/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377091
PNG
(3-[9-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyri...)
Show SMILES CC(c1cc(Cl)c(F)c2CN(CCOc12)C1CN(C1)S(=O)(=O)N(C)C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H28ClFN8O3S/c1-12-18-21(25)26-11-27-22(18)32(28-12)13(2)15-7-17(23)19(24)16-10-30(5-6-35-20(15)16)14-8-31(9-14)36(33,34)29(3)4/h7,11,13-14H,5-6,8-10H2,1-4H3,(H2,25,26,27)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377093
PNG
(1-{1-[7-chloro-6-fluoro-2- methyl-4-(1- propionyla...)
Show SMILES CCC(=O)N1CC(C1)N1CC(C)Oc2c(cc(Cl)c(F)c2C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H29ClFN7O2/c1-5-19(34)32-8-15(9-32)31-7-12(2)35-22-16(6-18(25)21(26)17(22)10-31)14(4)33-24-20(13(3)30-33)23(27)28-11-29-24/h6,11-12,14-15H,5,7-10H2,1-4H3,(H2,27,28,29)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377094
PNG
((2R)-1-[9-[1-(4-amino-3- methyl-1H-pyrazolo[3,4- d...)
Show SMILES C[C@@H](O)CN1CC(C)Oc2c(cc(Cl)c(F)c2C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H26ClFN6O2/c1-10(30)6-28-7-11(2)31-19-14(5-16(22)18(23)15(19)8-28)13(4)29-21-17(12(3)27-29)20(24)25-9-26-21/h5,9-11,13,30H,6-8H2,1-4H3,(H2,24,25,26)/t10-,11?,13?/m1/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377098
PNG
(3-[9-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyri...)
Show SMILES CC(c1cc(Cl)c(F)c2CN(C[C@H](C)Oc12)C1CN(C1)S(N)(=O)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H26ClFN8O3S/c1-10-5-29(13-6-30(7-13)35(25,32)33)8-15-18(23)16(22)4-14(19(15)34-10)12(3)31-21-17(11(2)28-31)20(24)26-9-27-21/h4,9-10,12-13H,5-8H2,1-3H3,(H2,24,26,27)(H2,25,32,33)/t10-,12?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377115
PNG
(3-[9-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyri...)
Show SMILES CCNC(=O)N1CC(C1)N1C[C@H](C)Oc2c(cc(Cl)c(C#N)c2C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C25H30ClN9O2/c1-5-29-25(36)34-9-16(10-34)33-8-13(2)37-22-17(6-20(26)18(7-27)19(22)11-33)15(4)35-24-21(14(3)32-35)23(28)30-12-31-24/h6,12-13,15-16H,5,8-11H2,1-4H3,(H,29,36)(H2,28,30,31)/t13-,15?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377117
PNG
(US10259818, Example 99 | ethyl 3-[9-[1-(4-amino-3-...)
Show SMILES CCOC(=O)N1CC(C1)N1C[C@H](C)Oc2c(cc(Cl)c(C#N)c2C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C25H29ClN8O3/c1-5-36-25(35)33-9-16(10-33)32-8-13(2)37-22-17(6-20(26)18(7-27)19(22)11-32)15(4)34-24-21(14(3)31-34)23(28)29-12-30-24/h6,12-13,15-16H,5,8-11H2,1-4H3,(H2,28,29,30)/t13-,15?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377118
PNG
(US10259818, Example 100 | ethyl 3-[9-[1-(4-amino-3...)
Show SMILES CCOC(=O)N1CC(C1)N1C[C@@H](C)Oc2c(cc(Cl)c(C#N)c2C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C25H29ClN8O3/c1-5-36-25(35)33-9-16(10-33)32-8-13(2)37-22-17(6-20(26)18(7-27)19(22)11-32)15(4)34-24-21(14(3)31-34)23(28)29-12-30-24/h6,12-13,15-16H,5,8-11H2,1-4H3,(H2,28,29,30)/t13-,15?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377126
PNG
(9-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyrimid...)
Show SMILES CC(c1cc(Cl)c(C#N)c2CN(CC#N)C[C@@H](C)Oc12)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H21ClN8O/c1-11-8-29(5-4-23)9-16-15(7-24)17(22)6-14(19(16)31-11)13(3)30-21-18(12(2)28-30)20(25)26-10-27-21/h6,10-11,13H,5,8-9H2,1-3H3,(H2,25,26,27)/t11-,13?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377131
PNG
(3-[9-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyri...)
Show SMILES CNC(=O)C1CC(C1)N1C[C@@H](C)Oc2c(cc(Cl)c(C#N)c2C1)[C@@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C25H29ClN8O2/c1-12-9-33(16-5-15(6-16)25(35)29-4)10-19-18(8-27)20(26)7-17(22(19)36-12)14(3)34-24-21(13(2)32-34)23(28)30-11-31-24/h7,11-12,14-16H,5-6,9-10H2,1-4H3,(H,29,35)(H2,28,30,31)/t12-,14-,15?,16?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377021
PNG
(US10259818, Example 3)
Show SMILES CC(c1cc(Cl)c(C)c2CN(CCOc12)C1CC(C1)C(=O)OC(C)(C)C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C27H35ClN6O3/c1-14-20-12-33(18-9-17(10-18)26(35)37-27(4,5)6)7-8-36-23(20)19(11-21(14)28)16(3)34-25-22(15(2)32-34)24(29)30-13-31-25/h11,13,16-18H,7-10,12H2,1-6H3,(H2,29,30,31)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377023
PNG
(US10259818, Example 5)
Show SMILES CC(c1cc(Cl)c(C)c2CN(CCOc12)C1CCC1)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H27ClN6O/c1-12-17-10-28(15-5-4-6-15)7-8-30-20(17)16(9-18(12)23)14(3)29-22-19(13(2)27-29)21(24)25-11-26-22/h9,11,14-15H,4-8,10H2,1-3H3,(H2,24,25,26)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377030
PNG
(US10259818, Example 12)
Show SMILES CC(c1cc(Cl)c(C)c2CN(CCOc12)C(=O)CC#N)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H22ClN7O2/c1-11-15-9-28(17(30)4-5-23)6-7-31-19(15)14(8-16(11)22)13(3)29-21-18(12(2)27-29)20(24)25-10-26-21/h8,10,13H,4,6-7,9H2,1-3H3,(H2,24,25,26)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377046
PNG
(US10259818, Example 28)
Show SMILES C[C@H](c1cc(Cl)c(F)c2CN(CC(C)Oc12)C1CN(C1)C(C)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H27ClFN7O2/c1-11-6-31(15-7-30(8-15)14(4)33)9-17-20(25)18(24)5-16(21(17)34-11)13(3)32-23-19(12(2)29-32)22(26)27-10-28-23/h5,10-11,13,15H,6-9H2,1-4H3,(H2,26,27,28)/t11?,13-/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377047
PNG
(US10259818, Example 29)
Show SMILES C[C@@H](c1cc(Cl)c(F)c2CN(CC(C)Oc12)C1CN(C1)C(C)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H27ClFN7O2/c1-11-6-31(15-7-30(8-15)14(4)33)9-17-20(25)18(24)5-16(21(17)34-11)13(3)32-23-19(12(2)29-32)22(26)27-10-28-23/h5,10-11,13,15H,6-9H2,1-4H3,(H2,26,27,28)/t11?,13-/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377062
PNG
(US10259818, Example 44)
Show SMILES CC(c1cc(Cl)c(F)c2CN(C[C@@H](C)Oc12)C1CC(C1)C(N)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H27ClFN7O2/c1-10-7-31(14-4-13(5-14)22(27)33)8-16-19(25)17(24)6-15(20(16)34-10)12(3)32-23-18(11(2)30-32)21(26)28-9-29-23/h6,9-10,12-14H,4-5,7-8H2,1-3H3,(H2,27,33)(H2,26,28,29)/t10-,12?,13?,14?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377095
PNG
((2R)-1-[9-[1-(4-amino-3- methyl-1H-pyrazolo[3,4- d...)
Show SMILES C[C@H](O)CN1CC(C)Oc2c(cc(Cl)c(F)c2C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H26ClFN6O2/c1-10(30)6-28-7-11(2)31-19-14(5-16(22)18(23)15(19)8-28)13(4)29-21-17(12(3)27-29)20(24)25-9-26-21/h5,9-11,13,30H,6-8H2,1-4H3,(H2,24,25,26)/t10-,11?,13?/m0/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377096
PNG
(US10259818, Example 79 | methyl 3-[9-[1-(4-amino-3...)
Show SMILES COC(=O)N1CC(C1)N1C[C@H](C)Oc2c(cc(Cl)c(F)c2C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H27ClFN7O3/c1-11-6-30(14-7-31(8-14)23(33)34-4)9-16-19(25)17(24)5-15(20(16)35-11)13(3)32-22-18(12(2)29-32)21(26)27-10-28-22/h5,10-11,13-14H,6-9H2,1-4H3,(H2,26,27,28)/t11-,13?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377107
PNG
(9-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyrimid...)
Show SMILES CCC(=O)N1CC(C1)N1CCOc2c(cc(Cl)c(C#N)c2C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H27ClN8O2/c1-4-20(34)32-9-15(10-32)31-5-6-35-22-16(7-19(25)17(8-26)18(22)11-31)14(3)33-24-21(13(2)30-33)23(27)28-12-29-24/h7,12,14-15H,4-6,9-11H2,1-3H3,(H2,27,28,29)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377108
PNG
(9-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyrimid...)
Show SMILES CC(c1cc(Cl)c(C#N)c2CN(CCOc12)C1CN(C1)S(C)(=O)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H25ClN8O3S/c1-12-19-21(25)26-11-27-22(19)31(28-12)13(2)15-6-18(23)16(7-24)17-10-29(4-5-34-20(15)17)14-8-30(9-14)35(3,32)33/h6,11,13-14H,4-5,8-10H2,1-3H3,(H2,25,26,27)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377110
PNG
(US10259818, Example 92 | ethyl 3-[9-[1-(4-amino-3-...)
Show SMILES CCOC(=O)N1CC(C1)N1CCOc2c(cc(Cl)c(C#N)c2C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H27ClN8O3/c1-4-35-24(34)32-9-15(10-32)31-5-6-36-21-16(7-19(25)17(8-26)18(21)11-31)14(3)33-23-20(13(2)30-33)22(27)28-12-29-23/h7,12,14-15H,4-6,9-11H2,1-3H3,(H2,27,28,29)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377123
PNG
(3-[9-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyri...)
Show SMILES CC(c1cc(Cl)c(C#N)c2CN(C[C@H](C)Oc12)C1CN(C1)S(=O)(=O)N(C)C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H30ClN9O3S/c1-13-8-32(16-9-33(10-16)38(35,36)31(4)5)11-19-18(7-26)20(25)6-17(22(19)37-13)15(3)34-24-21(14(2)30-34)23(27)28-12-29-24/h6,12-13,15-16H,8-11H2,1-5H3,(H2,27,28,29)/t13-,15?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377125
PNG
(9-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyrimid...)
Show SMILES CC(c1cc(Cl)c(C#N)c2CN(CC#N)C[C@H](C)Oc12)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H21ClN8O/c1-11-8-29(5-4-23)9-16-15(7-24)17(22)6-14(19(16)31-11)13(3)30-21-18(12(2)28-30)20(25)26-10-27-21/h6,10-11,13H,5,8-9H2,1-3H3,(H2,25,26,27)/t11-,13?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377132
PNG
(3-[9-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyri...)
Show SMILES CNC(=O)C1CC(C1)N1C[C@H](C)Oc2c(cc(Cl)c(C#N)c2C1)[C@@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C25H29ClN8O2/c1-12-9-33(16-5-15(6-16)25(35)29-4)10-19-18(8-27)20(26)7-17(22(19)36-12)14(3)34-24-21(13(2)32-34)23(28)30-11-31-24/h7,11-12,14-16H,5-6,9-10H2,1-4H3,(H,29,35)(H2,28,30,31)/t12-,14+,15?,16?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377024
PNG
(US10259818, Example 6)
Show SMILES CC(c1cc(Cl)c(C)c2CN(CCOc12)C1CCCC1)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H29ClN6O/c1-13-18-11-29(16-6-4-5-7-16)8-9-31-21(18)17(10-19(13)24)15(3)30-23-20(14(2)28-30)22(25)26-12-27-23/h10,12,15-16H,4-9,11H2,1-3H3,(H2,25,26,27)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377025
PNG
(US10259818, Example 7)
Show SMILES CC(c1cc(Cl)c(C)c2CN(CCOc12)C1CCCCC1)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H31ClN6O/c1-14-19-12-30(17-7-5-4-6-8-17)9-10-32-22(19)18(11-20(14)25)16(3)31-24-21(15(2)29-31)23(26)27-13-28-24/h11,13,16-17H,4-10,12H2,1-3H3,(H2,26,27,28)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377027
PNG
(US10259818, Example 9)
Show SMILES CC(c1cc(Cl)c(C)c2CN(C)CCOc12)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C19H23ClN6O/c1-10-14-8-25(4)5-6-27-17(14)13(7-15(10)20)12(3)26-19-16(11(2)24-26)18(21)22-9-23-19/h7,9,12H,5-6,8H2,1-4H3,(H2,21,22,23)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377029
PNG
(US10259818, Example 11)
Show SMILES CC(c1cc(Cl)c(C)c2CN(CC#N)CCOc12)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C20H22ClN7O/c1-11-15-9-27(5-4-22)6-7-29-18(15)14(8-16(11)21)13(3)28-20-17(12(2)26-28)19(23)24-10-25-20/h8,10,13H,5-7,9H2,1-3H3,(H2,23,24,25)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377036
PNG
(US10259818, Example 18)
Show SMILES CC(c1cc(Cl)c(C)c2CN(CCOc12)S(=O)(=O)C1CC1)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H25ClN6O3S/c1-11-16-9-27(32(29,30)14-4-5-14)6-7-31-19(16)15(8-17(11)22)13(3)28-21-18(12(2)26-28)20(23)24-10-25-21/h8,10,13-14H,4-7,9H2,1-3H3,(H2,23,24,25)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377040
PNG
(US10259818, Example 22)
Show SMILES CC(C)C(=O)N1CCOc2c(cc(Cl)c(C)c2C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H27ClN6O2/c1-11(2)22(30)28-6-7-31-19-15(8-17(23)12(3)16(19)9-28)14(5)29-21-18(13(4)27-29)20(24)25-10-26-21/h8,10-11,14H,6-7,9H2,1-5H3,(H2,24,25,26)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377074
PNG
(US10259818, Example 103 | US10259818, Example 56)
Show SMILES CC(c1cc(Cl)c(C#N)c2CN(C[C@H](C)Oc12)C1CN(CCO)C1)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H29ClN8O2/c1-13-8-32(16-9-31(10-16)4-5-34)11-19-18(7-26)20(25)6-17(22(19)35-13)15(3)33-24-21(14(2)30-33)23(27)28-12-29-24/h6,12-13,15-16,34H,4-5,8-11H2,1-3H3,(H2,27,28,29)/t13-,15?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377081
PNG
(US10259818, Example 63)
Show SMILES C[C@H](c1cc(Cl)c(C#N)c2CN(CCO)C[C@H](C)Oc12)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H24ClN7O2/c1-11-8-28(4-5-30)9-16-15(7-23)17(22)6-14(19(16)31-11)13(3)29-21-18(12(2)27-29)20(24)25-10-26-21/h6,10-11,13,30H,4-5,8-9H2,1-3H3,(H2,24,25,26)/t11-,13+/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377087
PNG
(US10259818, Example 69)
Show SMILES CC[C@H]1CN(CCO)Cc2c(O1)c(cc(Cl)c2C#N)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H26ClN7O2/c1-4-14-9-29(5-6-31)10-17-16(8-24)18(23)7-15(20(17)32-14)13(3)30-22-19(12(2)28-30)21(25)26-11-27-22/h7,11,13-14,31H,4-6,9-10H2,1-3H3,(H2,25,26,27)/t13?,14-/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377090
PNG
(3-[9-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyri...)
Show SMILES CC(c1cc(Cl)c(F)c2CN(CCOc12)C1CN(C1)C(=O)N(C)C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H28ClFN8O2/c1-12-18-21(26)27-11-28-22(18)33(29-12)13(2)15-7-17(24)19(25)16-10-31(5-6-35-20(15)16)14-8-32(9-14)23(34)30(3)4/h7,11,13-14H,5-6,8-10H2,1-4H3,(H2,26,27,28)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377100
PNG
(3-[9-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyri...)
Show SMILES CC(c1cc(Cl)c(F)c2CN(C[C@@H](C)Oc12)C1CN(C1)S(N)(=O)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H26ClFN8O3S/c1-10-5-29(13-6-30(7-13)35(25,32)33)8-15-18(23)16(22)4-14(19(15)34-10)12(3)31-21-17(11(2)28-31)20(24)26-9-27-21/h4,9-10,12-13H,5-8H2,1-3H3,(H2,24,26,27)(H2,25,32,33)/t10-,12?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377109
PNG
(3-[9-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyri...)
Show SMILES CC(C)NC(=O)N1CC(C1)N1CCOc2c(cc(Cl)c(C#N)c2C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C25H30ClN9O2/c1-13(2)31-25(36)34-9-16(10-34)33-5-6-37-22-17(7-20(26)18(8-27)19(22)11-33)15(4)35-24-21(14(3)32-35)23(28)29-12-30-24/h7,12-13,15-16H,5-6,9-11H2,1-4H3,(H,31,36)(H2,28,29,30)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377020
PNG
(US10259818, Example 2)
Show SMILES CC(c1cc(Cl)c(C)c2CNCCOc12)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C18H21ClN6O/c1-9-13-7-21-4-5-26-16(13)12(6-14(9)19)11(3)25-18-15(10(2)24-25)17(20)22-8-23-18/h6,8,11,21H,4-5,7H2,1-3H3,(H2,20,22,23)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377028
PNG
(US10259818, Example 10)
Show SMILES CC(C)N1CCOc2c(cc(Cl)c(C)c2C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H27ClN6O/c1-11(2)27-6-7-29-19-15(8-17(22)12(3)16(19)9-27)14(5)28-21-18(13(4)26-28)20(23)24-10-25-21/h8,10-11,14H,6-7,9H2,1-5H3,(H2,23,24,25)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377031
PNG
(US10259818, Example 13)
Show SMILES CC(c1cc(Cl)c(C)c2CN(CCOc12)S(C)(=O)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C19H23ClN6O3S/c1-10-14-8-25(30(4,27)28)5-6-29-17(14)13(7-15(10)20)12(3)26-19-16(11(2)24-26)18(21)22-9-23-19/h7,9,12H,5-6,8H2,1-4H3,(H2,21,22,23)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377048
PNG
(US10259818, Example 30)
Show SMILES C[C@H](c1cc(Cl)c(F)c2CN(C[C@@H](C)Oc12)C1CN(C1)C(C)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H27ClFN7O2/c1-11-6-31(15-7-30(8-15)14(4)33)9-17-20(25)18(24)5-16(21(17)34-11)13(3)32-23-19(12(2)29-32)22(26)27-10-28-23/h5,10-11,13,15H,6-9H2,1-4H3,(H2,26,27,28)/t11-,13-/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377055
PNG
(US10259818, Example 37)
Show SMILES C[C@H](c1cc(Cl)c(F)c2CN(C[C@@H](C)Oc12)S(C)(=O)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C19H22ClFN6O3S/c1-9-6-26(31(4,28)29)7-13-16(21)14(20)5-12(17(13)30-9)11(3)27-19-15(10(2)25-27)18(22)23-8-24-19/h5,8-9,11H,6-7H2,1-4H3,(H2,22,23,24)/t9-,11-/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377067
PNG
(US10259818, Example 49)
Show SMILES CC(c1cc(Cl)c(C#N)c2CN(C[C@@H](C)Oc12)C1CN(C1)C(C)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H27ClN8O2/c1-12-7-32(16-8-31(9-16)15(4)34)10-19-18(6-26)20(25)5-17(22(19)35-12)14(3)33-24-21(13(2)30-33)23(27)28-11-29-24/h5,11-12,14,16H,7-10H2,1-4H3,(H2,27,28,29)/t12-,14?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377072
PNG
(US10259818, Example 54)
Show SMILES CC(c1cc(Cl)c(C#N)c2CN(C[C@H](C)Oc12)C1CN(CC(C)(C)O)C1)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C26H33ClN8O2/c1-14-8-34(17-9-33(10-17)12-26(4,5)36)11-20-19(7-28)21(27)6-18(23(20)37-14)16(3)35-25-22(15(2)32-35)24(29)30-13-31-25/h6,13-14,16-17,36H,8-12H2,1-5H3,(H2,29,30,31)/t14-,16?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377077
PNG
(US10259818, Example 59)
Show SMILES CC(c1cc(Cl)c(C#N)c2CN(Cc3cccnc3)C[C@H](C)Oc12)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C25H25ClN8O/c1-14-10-33(11-17-5-4-6-29-9-17)12-20-19(8-27)21(26)7-18(23(20)35-14)16(3)34-25-22(15(2)32-34)24(28)30-13-31-25/h4-7,9,13-14,16H,10-12H2,1-3H3,(H2,28,30,31)/t14-,16?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377078
PNG
(US10259818, Example 60)
Show SMILES CC(c1cc(Cl)c(C#N)c2CN(Cc3cccnc3)C[C@@H](C)Oc12)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C25H25ClN8O/c1-14-10-33(11-17-5-4-6-29-9-17)12-20-19(8-27)21(26)7-18(23(20)35-14)16(3)34-25-22(15(2)32-34)24(28)30-13-31-25/h4-7,9,13-14,16H,10-12H2,1-3H3,(H2,28,30,31)/t14-,16?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377103
PNG
((2S)-1-{3-[(2S)-9-[(1S)-1- (4-amino-3-methyl-1H- p...)
Show SMILES C[C@H](O)CN1CC(C1)N1C[C@H](C)Oc2c(cc(Cl)c(F)c2C1)[C@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H31ClFN7O2/c1-12(34)6-31-8-16(9-31)32-7-13(2)35-22-17(5-19(25)21(26)18(22)10-32)15(4)33-24-20(14(3)30-33)23(27)28-11-29-24/h5,11-13,15-16,34H,6-10H2,1-4H3,(H2,27,28,29)/t12-,13-,15-/m0/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377104
PNG
((2R)-1-{3-[(2S)-9-[(1S)-1- (4-amino-3-methyl-1H- p...)
Show SMILES C[C@@H](O)CN1CC(C1)N1C[C@H](C)Oc2c(cc(Cl)c(F)c2C1)[C@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H31ClFN7O2/c1-12(34)6-31-8-16(9-31)32-7-13(2)35-22-17(5-19(25)21(26)18(22)10-32)15(4)33-24-20(14(3)30-33)23(27)28-11-29-24/h5,11-13,15-16,34H,6-10H2,1-4H3,(H2,27,28,29)/t12-,13+,15+/m1/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377114
PNG
(9-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyrimid...)
Show SMILES CCC(=O)N1CC(C1)N1C[C@H](C)Oc2c(cc(Cl)c(C#N)c2C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C25H29ClN8O2/c1-5-21(35)33-9-16(10-33)32-8-13(2)36-23-17(6-20(26)18(7-27)19(23)11-32)15(4)34-25-22(14(3)31-34)24(28)29-12-30-25/h6,12-13,15-16H,5,8-11H2,1-4H3,(H2,28,29,30)/t13-,15?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377120
PNG
(3-[9-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyri...)
Show SMILES CC(C)NC(=O)N1CC(C1)N1C[C@@H](C)Oc2c(cc(Cl)c(C#N)c2C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C26H32ClN9O2/c1-13(2)32-26(37)35-9-17(10-35)34-8-14(3)38-23-18(6-21(27)19(7-28)20(23)11-34)16(5)36-25-22(15(4)33-36)24(29)30-12-31-25/h6,12-14,16-17H,8-11H2,1-5H3,(H,32,37)(H2,29,30,31)/t14-,16?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377127
PNG
(2-[9-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyri...)
Show SMILES CC(c1cc(Cl)c(C#N)c2CN(CC(N)=O)C[C@@H](C)Oc12)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H23ClN8O2/c1-10-6-29(8-17(24)31)7-15-14(5-23)16(22)4-13(19(15)32-10)12(3)30-21-18(11(2)28-30)20(25)26-9-27-21/h4,9-10,12H,6-8H2,1-3H3,(H2,24,31)(H2,25,26,27)/t10-,12?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377037
PNG
(US10259818, Example 19)
Show SMILES CC(c1cc(Cl)c(C)c2CN(CCOc12)C(C)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C20H23ClN6O2/c1-10-15-8-26(13(4)28)5-6-29-18(15)14(7-16(10)21)12(3)27-20-17(11(2)25-27)19(22)23-9-24-20/h7,9,12H,5-6,8H2,1-4H3,(H2,22,23,24)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377039
PNG
(US10259818, Example 21)
Show SMILES COCC(=O)N1CCOc2c(cc(Cl)c(C)c2C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H25ClN6O3/c1-11-15-8-27(17(29)9-30-4)5-6-31-19(15)14(7-16(11)22)13(3)28-21-18(12(2)26-28)20(23)24-10-25-21/h7,10,13H,5-6,8-9H2,1-4H3,(H2,23,24,25)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377042
PNG
(US10259818, Example 24)
Show SMILES CC(c1cc(Cl)c(C)c2CN(CCOc12)c1cnccn1)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H23ClN8O/c1-12-16-10-30(18-9-25-4-5-26-18)6-7-32-20(16)15(8-17(12)23)14(3)31-22-19(13(2)29-31)21(24)27-11-28-22/h4-5,8-9,11,14H,6-7,10H2,1-3H3,(H2,24,27,28)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377053
PNG
(US10259818, Example 35)
Show SMILES CC(c1cc(Cl)c(F)c2CN([C@@H](C)COc12)S(C)(=O)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C19H22ClFN6O3S/c1-9-7-30-17-12(5-14(20)16(21)13(17)6-26(9)31(4,28)29)11(3)27-19-15(10(2)25-27)18(22)23-8-24-19/h5,8-9,11H,6-7H2,1-4H3,(H2,22,23,24)/t9-,11?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377058
PNG
(US10259818, Example 40)
Show SMILES C[C@@H](c1cc(Cl)c(F)c2CN(C[C@H](C)Oc12)S(C)(=O)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C19H22ClFN6O3S/c1-9-6-26(31(4,28)29)7-13-16(21)14(20)5-12(17(13)30-9)11(3)27-19-15(10(2)25-27)18(22)23-8-24-19/h5,8-9,11H,6-7H2,1-4H3,(H2,22,23,24)/t9-,11-/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377063
PNG
(US10259818, Example 45)
Show SMILES CC(c1cc(Cl)c(F)c2CN(CCCOc12)S(C)(=O)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C19H22ClFN6O3S/c1-10-15-18(22)23-9-24-19(15)27(25-10)11(2)12-7-14(20)16(21)13-8-26(31(3,28)29)5-4-6-30-17(12)13/h7,9,11H,4-6,8H2,1-3H3,(H2,22,23,24)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377064
PNG
(US10259818, Example 46)
Show SMILES CC(c1cc(Cl)c(C#N)c2CN(CCOc12)C1CN(C1)C(C)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H25ClN8O2/c1-12-20-22(26)27-11-28-23(20)32(29-12)13(2)16-6-19(24)17(7-25)18-10-30(4-5-34-21(16)18)15-8-31(9-15)14(3)33/h6,11,13,15H,4-5,8-10H2,1-3H3,(H2,26,27,28)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377111
PNG
(9-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyrimid...)
Show SMILES CC(c1cc(Cl)c(C#N)c2CN(C[C@H](C)Oc12)C1CN(C1)S(C)(=O)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H27ClN8O3S/c1-12-7-30(15-8-31(9-15)36(4,33)34)10-18-17(6-25)19(24)5-16(21(18)35-12)14(3)32-23-20(13(2)29-32)22(26)27-11-28-23/h5,11-12,14-15H,7-10H2,1-4H3,(H2,26,27,28)/t12-,14?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377113
PNG
(9-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyrimid...)
Show SMILES CCC(=O)N1CC(C1)N1C[C@@H](C)Oc2c(cc(Cl)c(C#N)c2C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C25H29ClN8O2/c1-5-21(35)33-9-16(10-33)32-8-13(2)36-23-17(6-20(26)18(7-27)19(23)11-32)15(4)34-25-22(14(3)31-34)24(28)29-12-30-25/h6,12-13,15-16H,5,8-11H2,1-4H3,(H2,28,29,30)/t13-,15?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377124
PNG
(US10259818, Example 106)
Show SMILES CC(c1cc(Cl)c(C#N)c2CN(C[C@@H](C)Oc12)C1CN(C1)S(=O)(=O)N(C)C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H30ClN9O3S/c1-13-8-32(16-9-33(10-16)38(35,36)31(4)5)11-19-18(7-26)20(25)6-17(22(19)37-13)15(3)34-24-21(14(2)30-34)23(27)28-12-29-24/h6,12-13,15-16H,8-11H2,1-5H3,(H2,27,28,29)/t13-,15?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377129
PNG
(9-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyrimid...)
Show SMILES COCCN1C[C@H](C)Oc2c(cc(Cl)c(C#N)c2C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H26ClN7O2/c1-12-9-29(5-6-31-4)10-17-16(8-24)18(23)7-15(20(17)32-12)14(3)30-22-19(13(2)28-30)21(25)26-11-27-22/h7,11-12,14H,5-6,9-10H2,1-4H3,(H2,25,26,27)/t12-,14?/s2
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377133
PNG
(US10259818, Example 115)
Show SMILES CNC(=O)C1CC(C1)N1C[C@H](C)Oc2c(cc(Cl)c(C#N)c2C1)[C@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C25H29ClN8O2/c1-12-9-33(16-5-15(6-16)25(35)29-4)10-19-18(8-27)20(26)7-17(22(19)36-12)14(3)34-24-21(13(2)32-34)23(28)30-11-31-24/h7,11-12,14-16H,5-6,9-10H2,1-4H3,(H,29,35)(H2,28,30,31)/t12-,14-,15?,16?/s2
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377032
PNG
(US10259818, Example 14)
Show SMILES CC(c1cc(Cl)c(C)c2CN(CCOc12)S(=O)(=O)c1ccccc1)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H25ClN6O3S/c1-14-19-12-30(35(32,33)17-7-5-4-6-8-17)9-10-34-22(19)18(11-20(14)25)16(3)31-24-21(15(2)29-31)23(26)27-13-28-24/h4-8,11,13,16H,9-10,12H2,1-3H3,(H2,26,27,28)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377034
PNG
(US10259818, Example 16)
Show SMILES CC(c1cc(Cl)c(C)c2CN(CCOc12)C(=O)c1ccccc1)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C25H25ClN6O2/c1-14-19-12-31(25(33)17-7-5-4-6-8-17)9-10-34-22(19)18(11-20(14)26)16(3)32-24-21(15(2)30-32)23(27)28-13-29-24/h4-8,11,13,16H,9-10,12H2,1-3H3,(H2,27,28,29)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377041
PNG
(US10259818, Example 23)
Show SMILES CC(c1cc(Cl)c(C)c2CN(CCOc12)c1ncc(s1)C#N)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H21ClN8OS/c1-11-16-9-30(22-26-8-14(7-24)33-22)4-5-32-19(16)15(6-17(11)23)13(3)31-21-18(12(2)29-31)20(25)27-10-28-21/h6,8,10,13H,4-5,9H2,1-3H3,(H2,25,27,28)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377043
PNG
(US10259818, Example 25)
Show SMILES CC(c1cc(Cl)c(C)c2c1OCCNC2=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C18H19ClN6O2/c1-8-12(19)6-11(15-13(8)18(26)21-4-5-27-15)10(3)25-17-14(9(2)24-25)16(20)22-7-23-17/h6-7,10H,4-5H2,1-3H3,(H,21,26)(H2,20,22,23)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377045
PNG
(US10259818, Example 27)
Show SMILES C[C@@H](c1cc(Cl)c(F)c2CN(CC(C)Oc12)C1CN(C1)C(=O)OC(C)(C)C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C26H33ClFN7O3/c1-13-8-33(16-9-34(10-16)25(36)38-26(4,5)6)11-18-21(28)19(27)7-17(22(18)37-13)15(3)35-24-20(14(2)32-35)23(29)30-12-31-24/h7,12-13,15-16H,8-11H2,1-6H3,(H2,29,30,31)/t13?,15-/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377065
PNG
(US10259818, Example 47)
Show SMILES CC(c1cc(Cl)c(C#N)c2CN(CCOc12)C1CN(CCO)C1)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H27ClN8O2/c1-13-20-22(26)27-12-28-23(20)32(29-13)14(2)16-7-19(24)17(8-25)18-11-31(4-6-34-21(16)18)15-9-30(10-15)3-5-33/h7,12,14-15,33H,3-6,9-11H2,1-2H3,(H2,26,27,28)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377069
PNG
(US10259818, Example 51 | US10259818, Example 53)
Show SMILES CC(c1cc(Cl)c(C#N)c2CN(C[C@@H](C)Oc12)C1CN(CC(N)=O)C1)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H28ClN9O2/c1-12-6-33(15-7-32(8-15)10-20(27)35)9-18-17(5-26)19(25)4-16(22(18)36-12)14(3)34-24-21(13(2)31-34)23(28)29-11-30-24/h4,11-12,14-15H,6-10H2,1-3H3,(H2,27,35)(H2,28,29,30)/t12-,14?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377076
PNG
(US10259818, Example 58)
Show SMILES CC(c1cc(Cl)c(C#N)c2CN(CCO)CCOc12)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C20H22ClN7O2/c1-11-17-19(23)24-10-25-20(17)28(26-11)12(2)13-7-16(21)14(8-22)15-9-27(3-5-29)4-6-30-18(13)15/h7,10,12,29H,3-6,9H2,1-2H3,(H2,23,24,25)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377083
PNG
(US10259818, Example 65)
Show SMILES CC(c1cc(Cl)c(C#N)c2CN(CC(C)(C)O)C[C@H](C)Oc12)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H28ClN7O2/c1-12-8-30(10-23(4,5)32)9-17-16(7-25)18(24)6-15(20(17)33-12)14(3)31-22-19(13(2)29-31)21(26)27-11-28-22/h6,11-12,14,32H,8-10H2,1-5H3,(H2,26,27,28)/t12-,14?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377112
PNG
(9-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyrimid...)
Show SMILES CC(c1cc(Cl)c(C#N)c2CN(C[C@@H](C)Oc12)C1CN(C1)S(C)(=O)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H27ClN8O3S/c1-12-7-30(15-8-31(9-15)36(4,33)34)10-18-17(6-25)19(24)5-16(21(18)35-12)14(3)32-23-20(13(2)29-32)22(26)27-11-28-23/h5,11-12,14-15H,7-10H2,1-4H3,(H2,26,27,28)/t12-,14?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377116
PNG
(3-[9-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyri...)
Show SMILES CCNC(=O)N1CC(C1)N1C[C@@H](C)Oc2c(cc(Cl)c(C#N)c2C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C25H30ClN9O2/c1-5-29-25(36)34-9-16(10-34)33-8-13(2)37-22-17(6-20(26)18(7-27)19(22)11-33)15(4)35-24-21(14(3)32-35)23(28)30-12-31-24/h6,12-13,15-16H,5,8-11H2,1-4H3,(H,29,36)(H2,28,30,31)/t13-,15?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377119
PNG
(3-[9-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyri...)
Show SMILES CC(C)NC(=O)N1CC(C1)N1C[C@H](C)Oc2c(cc(Cl)c(C#N)c2C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C26H32ClN9O2/c1-13(2)32-26(37)35-9-17(10-35)34-8-14(3)38-23-18(6-21(27)19(7-28)20(23)11-34)16(5)36-25-22(15(4)33-36)24(29)30-12-31-25/h6,12-14,16-17H,8-11H2,1-5H3,(H,32,37)(H2,29,30,31)/t14-,16?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377074
PNG
(US10259818, Example 103 | US10259818, Example 56)
Show SMILES CC(c1cc(Cl)c(C#N)c2CN(C[C@H](C)Oc12)C1CN(CCO)C1)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H29ClN8O2/c1-13-8-32(16-9-31(10-16)4-5-34)11-19-18(7-26)20(25)6-17(22(19)35-13)15(3)33-24-21(14(2)30-33)23(27)28-12-29-24/h6,12-13,15-16,34H,4-5,8-11H2,1-3H3,(H2,27,28,29)/t13-,15?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377075
PNG
(US10259818, Example 104 | US10259818, Example 57)
Show SMILES CC(c1cc(Cl)c(C#N)c2CN(C[C@@H](C)Oc12)C1CN(CCO)C1)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H29ClN8O2/c1-13-8-32(16-9-31(10-16)4-5-34)11-19-18(7-26)20(25)6-17(22(19)35-13)15(3)33-24-21(14(2)30-33)23(27)28-12-29-24/h6,12-13,15-16,34H,4-5,8-11H2,1-3H3,(H2,27,28,29)/t13-,15?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377082
PNG
(US10259818, Example 64)
Show SMILES C[C@@H](c1cc(Cl)c(C#N)c2CN(CCO)C[C@H](C)Oc12)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H24ClN7O2/c1-11-8-28(4-5-30)9-16-15(7-23)17(22)6-14(19(16)31-11)13(3)29-21-18(12(2)27-29)20(24)25-10-26-21/h6,10-11,13,30H,4-5,8-9H2,1-3H3,(H2,24,25,26)/t11-,13-/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377066
PNG
(US10259818, Example 48)
Show SMILES CC(c1cc(Cl)c(C#N)c2CN(C[C@H](C)Oc12)C1CN(C1)C(C)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H27ClN8O2/c1-12-7-32(16-8-31(9-16)15(4)34)10-19-18(6-26)20(25)5-17(22(19)35-12)14(3)33-24-21(13(2)30-33)23(27)28-11-29-24/h5,11-12,14,16H,7-10H2,1-4H3,(H2,27,28,29)/t12-,14?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377051
PNG
(US10259818, Example 33)
Show SMILES C[C@@H](c1cc(Cl)c(F)c2CN(C[C@H](C)Oc12)C1CN(C1)C(C)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H27ClFN7O2/c1-11-6-31(15-7-30(8-15)14(4)33)9-17-20(25)18(24)5-16(21(17)34-11)13(3)32-23-19(12(2)29-32)22(26)27-10-28-23/h5,10-11,13,15H,6-9H2,1-4H3,(H2,26,27,28)/t11-,13-/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377105
PNG
(2-{3-[(2S)-9-[1-(4-amino- 3-methyl-1H-pyrazolo[3,4...)
Show SMILES CC(c1cc(Cl)c(F)c2CN(C[C@H](C)Oc12)C1CN(CC(N)=O)C1)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H28ClFN8O2/c1-11-5-32(14-6-31(7-14)9-18(26)34)8-16-20(25)17(24)4-15(21(16)35-11)13(3)33-23-19(12(2)30-33)22(27)28-10-29-23/h4,10-11,13-14H,5-9H2,1-3H3,(H2,26,34)(H2,27,28,29)/t11-,13?/m0/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377089
PNG
(US10259818, Example 72)
Show SMILES CC(c1cc(Cl)c(F)c2CN(C3CC(C3)NC(C)=O)C(=O)C(C)Oc12)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H27ClFN7O3/c1-10-19-22(27)28-9-29-23(19)33(31-10)11(2)16-7-18(25)20(26)17-8-32(24(35)12(3)36-21(16)17)15-5-14(6-15)30-13(4)34/h7,9,11-12,14-15H,5-6,8H2,1-4H3,(H,30,34)(H2,27,28,29)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377019
PNG
(US10259818, Example 1)
Show SMILES CC(c1cc(Cl)c(C)c2CN(CCOc12)C(=O)OC(C)(C)C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H29ClN6O3/c1-12-16-10-29(22(31)33-23(4,5)6)7-8-32-19(16)15(9-17(12)24)14(3)30-21-18(13(2)28-30)20(25)26-11-27-21/h9,11,14H,7-8,10H2,1-6H3,(H2,25,26,27)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377054
PNG
(US10259818, Example 36)
Show SMILES CC(c1cc(Cl)c(F)c2CN([C@H](C)COc12)S(C)(=O)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C19H22ClFN6O3S/c1-9-7-30-17-12(5-14(20)16(21)13(17)6-26(9)31(4,28)29)11(3)27-19-15(10(2)25-27)18(22)23-8-24-19/h5,8-9,11H,6-7H2,1-4H3,(H2,22,23,24)/t9-,11?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377079
PNG
(US10259818, Example 61)
Show SMILES C[C@H](c1cc(Cl)c(C#N)c2CN(CCO)C[C@@H](C)Oc12)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H24ClN7O2/c1-11-8-28(4-5-30)9-16-15(7-23)17(22)6-14(19(16)31-11)13(3)29-21-18(12(2)27-29)20(24)25-10-26-21/h6,10-11,13,30H,4-5,8-9H2,1-3H3,(H2,24,25,26)/t11-,13-/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377049
PNG
(US10259818, Example 31)
Show SMILES C[C@@H](c1cc(Cl)c(F)c2CN(C[C@@H](C)Oc12)C1CN(C1)C(C)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H27ClFN7O2/c1-11-6-31(15-7-30(8-15)14(4)33)9-17-20(25)18(24)5-16(21(17)34-11)13(3)32-23-19(12(2)29-32)22(26)27-10-28-23/h5,10-11,13,15H,6-9H2,1-4H3,(H2,26,27,28)/t11-,13+/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377056
PNG
(US10259818, Example 38)
Show SMILES C[C@@H](c1cc(Cl)c(F)c2CN(C[C@@H](C)Oc12)S(C)(=O)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C19H22ClFN6O3S/c1-9-6-26(31(4,28)29)7-13-16(21)14(20)5-12(17(13)30-9)11(3)27-19-15(10(2)25-27)18(22)23-8-24-19/h5,8-9,11H,6-7H2,1-4H3,(H2,22,23,24)/t9-,11+/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM377057
PNG
(US10259818, Example 39)
Show SMILES C[C@H](c1cc(Cl)c(F)c2CN(C[C@H](C)Oc12)S(C)(=O)=O)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C19H22ClFN6O3S/c1-9-6-26(31(4,28)29)7-13-16(21)14(20)5-12(17(13)30-9)11(3)27-19-15(10(2)25-27)18(22)23-8-24-19/h5,8-9,11H,6-7H2,1-4H3,(H2,22,23,24)/t9-,11+/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10259818 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%