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Patent code US10265310

Compile Data Set for Download or QSAR
Found 158 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377260
PNG
(US10265310, Example 6 | rac-trans-1-(4-bromophenyl...)
Show SMILES COc1ccc(cc1)[C@H]1CCNC[C@@H]1NC(=O)Nc1ccc(Br)cc1
Show InChI InChI=1/C19H22BrN3O2/c1-25-16-8-2-13(3-9-16)17-10-11-21-12-18(17)23-19(24)22-15-6-4-14(20)5-7-15/h2-9,17-18,21H,10-12H2,1H3,(H2,22,23,24)/t17-,18+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377263
PNG
(US10265310, Example 9 | rac-trans-1-(4-chloropheny...)
Show SMILES COc1cc(F)c([C@H]2CCNC[C@@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1/C19H20ClF2N3O2/c1-27-13-8-15(21)18(16(22)9-13)14-6-7-23-10-17(14)25-19(26)24-12-4-2-11(20)3-5-12/h2-5,8-9,14,17,23H,6-7,10H2,1H3,(H2,24,25,26)/t14-,17-/s2
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US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377264
PNG
(US10265310, Example 10 | trans-ent1-(4-chloropheny...)
Show SMILES COc1ccc(cc1)[C@H]1CC(=O)N(C)C[C@@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C20H22ClN3O3/c1-24-12-18(23-20(26)22-15-7-5-14(21)6-8-15)17(11-19(24)25)13-3-9-16(27-2)10-4-13/h3-10,17-18H,11-12H2,1-2H3,(H2,22,23,26)/t17-,18+/m1/s1
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377265
PNG
(US10265310, Example 11 | trans-ent2-(4-chloropheny...)
Show SMILES COc1ccc(cc1)[C@@H]1CC(=O)N(C)C[C@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C20H22ClN3O3/c1-24-12-18(23-20(26)22-15-7-5-14(21)6-8-15)17(11-19(24)25)13-3-9-16(27-2)10-4-13/h3-10,17-18H,11-12H2,1-2H3,(H2,22,23,26)/t17-,18+/m0/s1
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377266
PNG
(US10265310, Example 12 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(Cl)cc1)C(=O)C1CC1
Show InChI InChI=1/C23H26ClN3O3/c1-30-19-10-4-15(5-11-19)20-12-13-27(22(28)16-2-3-16)14-21(20)26-23(29)25-18-8-6-17(24)7-9-18/h4-11,16,20-21H,2-3,12-14H2,1H3,(H2,25,26,29)/t20-,21+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377260
PNG
(US10265310, Example 6 | rac-trans-1-(4-bromophenyl...)
Show SMILES COc1ccc(cc1)[C@H]1CCNC[C@@H]1NC(=O)Nc1ccc(Br)cc1
Show InChI InChI=1/C19H22BrN3O2/c1-25-16-8-2-13(3-9-16)17-10-11-21-12-18(17)23-19(24)22-15-6-4-14(20)5-7-15/h2-9,17-18,21H,10-12H2,1H3,(H2,22,23,24)/t17-,18+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377267
PNG
(US10265310, Example 13 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(Cl)cc1)C(=O)CO
Show InChI InChI=1/C21H24ClN3O4/c1-29-17-8-2-14(3-9-17)18-10-11-25(20(27)13-26)12-19(18)24-21(28)23-16-6-4-15(22)5-7-16/h2-9,18-19,26H,10-13H2,1H3,(H2,23,24,28)/t18-,19+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377269
PNG
(US10265310, Example 15 | rac-trans-1-(4-chlorophen...)
Show SMILES COCCC(=O)N1CC[C@@H]([C@H](C1)NC(=O)Nc1ccc(Cl)cc1)c1ccc(OC)cc1
Show InChI InChI=1/C23H28ClN3O4/c1-30-14-12-22(28)27-13-11-20(16-3-9-19(31-2)10-4-16)21(15-27)26-23(29)25-18-7-5-17(24)6-8-18/h3-10,20-21H,11-15H2,1-2H3,(H2,25,26,29)/t20-,21+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377273
PNG
(US10265310, Example 19 | rac-trans-1-(1-acetyl-4-(...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(Cl)nc1)C(C)=O
Show InChI InChI=1/C20H23ClN4O3/c1-13(26)25-10-9-17(14-3-6-16(28-2)7-4-14)18(12-25)24-20(27)23-15-5-8-19(21)22-11-15/h3-8,11,17-18H,9-10,12H2,1-2H3,(H2,23,24,27)/t17-,18+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377274
PNG
(US10265310, Example 20 | rac-trans-2-(5-(3-(4-chlo...)
Show SMILES COc1ccc(cc1)[C@H]1CC(=O)N(CC(N)=O)C[C@@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1/C21H23ClN4O4/c1-30-16-8-2-13(3-9-16)17-10-20(28)26(12-19(23)27)11-18(17)25-21(29)24-15-6-4-14(22)5-7-15/h2-9,17-18H,10-12H2,1H3,(H2,23,27)(H2,24,25,29)/t17-,18+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377278
PNG
(US10265310, Example 25 | rac-trans-1-(1-acetyl-4-(...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1cncnc1)C(C)=O
Show InChI InChI=1/C19H23N5O3/c1-13(25)24-8-7-17(14-3-5-16(27-2)6-4-14)18(11-24)23-19(26)22-15-9-20-12-21-10-15/h3-6,9-10,12,17-18H,7-8,11H2,1-2H3,(H2,22,23,26)/t17-,18+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377282
PNG
(US10265310, Example 29 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1cc(F)c([C@H]2CC(=O)N(CC3CC3)C[C@@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1/C23H24ClF2N3O3/c1-32-16-8-18(25)22(19(26)9-16)17-10-21(30)29(11-13-2-3-13)12-20(17)28-23(31)27-15-6-4-14(24)5-7-15/h4-9,13,17,20H,2-3,10-12H2,1H3,(H2,27,28,31)/t17-,20-/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377283
PNG
(US10265310, Example 30 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(Cl)cc1)C(=O)CCO
Show InChI InChI=1/C22H26ClN3O4/c1-30-18-8-2-15(3-9-18)19-10-12-26(21(28)11-13-27)14-20(19)25-22(29)24-17-6-4-16(23)5-7-17/h2-9,19-20,27H,10-14H2,1H3,(H2,24,25,29)/t19-,20+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377284
PNG
(US10265310, Example 31 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1cc(F)c([C@H]2CC(=O)N(CCO)C[C@@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1/C21H22ClF2N3O4/c1-31-14-8-16(23)20(17(24)9-14)15-10-19(29)27(6-7-28)11-18(15)26-21(30)25-13-4-2-12(22)3-5-13/h2-5,8-9,15,18,28H,6-7,10-11H2,1H3,(H2,25,26,30)/t15-,18-/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377286
PNG
(US10265310, Example 36 | trans-ent1-1-(4-chlorophe...)
Show SMILES COc1cc(F)c([C@H]2CCNC[C@@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1S/C19H20ClF2N3O2/c1-27-13-8-15(21)18(16(22)9-13)14-6-7-23-10-17(14)25-19(26)24-12-4-2-11(20)3-5-12/h2-5,8-9,14,17,23H,6-7,10H2,1H3,(H2,24,25,26)/t14-,17-/m0/s1
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377292
PNG
(US10265310, Example 45 | ent1-1-(4-chlorophenyl)-3...)
Show SMILES COc1ccc([C@H]2CCNC[C@@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1/C19H21ClFN3O2/c1-26-14-6-7-15(17(21)10-14)16-8-9-22-11-18(16)24-19(25)23-13-4-2-12(20)3-5-13/h2-7,10,16,18,22H,8-9,11H2,1H3,(H2,23,24,25)/t16-,18+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377297
PNG
(US10265310, Example 50 | trans-ent2-1-(4-chlorophe...)
Show SMILES COc1cc(F)c([C@@H]2CC(=O)NC[C@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1S/C19H18ClF2N3O3/c1-28-12-6-14(21)18(15(22)7-12)13-8-17(26)23-9-16(13)25-19(27)24-11-4-2-10(20)3-5-11/h2-7,13,16H,8-9H2,1H3,(H,23,26)(H2,24,25,27)/t13-,16-/m1/s1
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377306
PNG
(US10265310, Example 59 | US10265310, Example 60 | ...)
Show SMILES COCCN1CC(NC(=O)Nc2ccc(Cl)cc2)C(CC1=O)c1ccc(OC)cc1F
Show InChI InChI=1/C22H25ClFN3O4/c1-30-10-9-27-13-20(26-22(29)25-15-5-3-14(23)4-6-15)18(12-21(27)28)17-8-7-16(31-2)11-19(17)24/h3-8,11,18,20H,9-10,12-13H2,1-2H3,(H2,25,26,29)
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377308
PNG
(US10265310, Example 61 | US10265310, Example 62 | ...)
Show SMILES COc1ccc(C2CC(=O)N(CC(F)F)CC2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1/C21H21ClF3N3O3/c1-31-14-6-7-15(17(23)8-14)16-9-20(29)28(11-19(24)25)10-18(16)27-21(30)26-13-4-2-12(22)3-5-13/h2-8,16,18-19H,9-11H2,1H3,(H2,26,27,30)
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377310
PNG
(US10265310, Example 63 | US10265310, Example 64 | ...)
Show SMILES COCCN1CC(NC(=O)Nc2ccc(Cl)cc2)C(CC1=O)c1ccc(F)cc1F
Show InChI InChI=1/C21H22ClF2N3O3/c1-30-9-8-27-12-19(26-21(29)25-15-5-2-13(22)3-6-15)17(11-20(27)28)16-7-4-14(23)10-18(16)24/h2-7,10,17,19H,8-9,11-12H2,1H3,(H2,25,26,29)
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377318
PNG
(US10265310, Example 72 | rac-trans-1-(4-chlorophen...)
Show SMILES CSc1ccc(cc1)[C@H]1CC(=O)NC[C@@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1/C19H20ClN3O2S/c1-26-15-8-2-12(3-9-15)16-10-18(24)21-11-17(16)23-19(25)22-14-6-4-13(20)5-7-14/h2-9,16-17H,10-11H2,1H3,(H,21,24)(H2,22,23,25)/t16-,17+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377322
PNG
(US10265310, Example 76 | trans-ent1-1-(4-chlorophe...)
Show SMILES COc1ccc(cc1)[C@H]1CC(=O)NC[C@@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C19H20ClN3O3/c1-26-15-8-2-12(3-9-15)16-10-18(24)21-11-17(16)23-19(25)22-14-6-4-13(20)5-7-14/h2-9,16-17H,10-11H2,1H3,(H,21,24)(H2,22,23,25)/t16-,17+/m1/s1
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377325
PNG
(US10265310, Example 81 | trans-ent2-1-(4-chlorophe...)
Show SMILES Clc1ccc(NC(=O)N[C@@H]2CNCC[C@H]2c2ccccc2)cc1
Show InChI InChI=1S/C18H20ClN3O/c19-14-6-8-15(9-7-14)21-18(23)22-17-12-20-11-10-16(17)13-4-2-1-3-5-13/h1-9,16-17,20H,10-12H2,(H2,21,22,23)/t16-,17+/m0/s1
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377326
PNG
(US10265310, Example 83 | trans-ent1-1-(4-chlorophe...)
Show SMILES Clc1ccc(NC(=O)N[C@H]2CN(CC[C@@H]2c2ccccc2)C(=O)C2CC2)cc1
Show InChI InChI=1S/C22H24ClN3O2/c23-17-8-10-18(11-9-17)24-22(28)25-20-14-26(21(27)16-6-7-16)13-12-19(20)15-4-2-1-3-5-15/h1-5,8-11,16,19-20H,6-7,12-14H2,(H2,24,25,28)/t19-,20+/m1/s1
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377330
PNG
(US10265310, Example 89 | US10265310, Example 90 | ...)
Show SMILES COc1ccc(cc1)C1C(CCCN1C)NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1/C20H24ClN3O2/c1-24-13-3-4-18(19(24)14-5-11-17(26-2)12-6-14)23-20(25)22-16-9-7-15(21)8-10-16/h5-12,18-19H,3-4,13H2,1-2H3,(H2,22,23,25)
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377265
PNG
(US10265310, Example 11 | trans-ent2-(4-chloropheny...)
Show SMILES COc1ccc(cc1)[C@@H]1CC(=O)N(C)C[C@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C20H22ClN3O3/c1-24-12-18(23-20(26)22-15-7-5-14(21)6-8-15)17(11-19(24)25)13-3-9-16(27-2)10-4-13/h3-10,17-18H,11-12H2,1-2H3,(H2,22,23,26)/t17-,18+/m0/s1
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377278
PNG
(US10265310, Example 25 | rac-trans-1-(1-acetyl-4-(...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1cncnc1)C(C)=O
Show InChI InChI=1/C19H23N5O3/c1-13(25)24-8-7-17(14-3-5-16(27-2)6-4-14)18(11-24)23-19(26)22-15-9-20-12-21-10-15/h3-6,9-10,12,17-18H,7-8,11H2,1-2H3,(H2,22,23,26)/t17-,18+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377280
PNG
(US10265310, Example 27 | rac-trans-1-(1-acetyl-4-(...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(nc1)C(F)(F)F)C(C)=O
Show InChI InChI=1/C21H23F3N4O3/c1-13(29)28-10-9-17(14-3-6-16(31-2)7-4-14)18(12-28)27-20(30)26-15-5-8-19(25-11-15)21(22,23)24/h3-8,11,17-18H,9-10,12H2,1-2H3,(H2,26,27,30)/t17-,18+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377283
PNG
(US10265310, Example 30 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(Cl)cc1)C(=O)CCO
Show InChI InChI=1/C22H26ClN3O4/c1-30-18-8-2-15(3-9-18)19-10-12-26(21(28)11-13-27)14-20(19)25-22(29)24-17-6-4-16(23)5-7-17/h2-9,19-20,27H,10-14H2,1H3,(H2,24,25,29)/t19-,20+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377290
PNG
(US10265310, Example 42 | trans-ent1-1-(4-chlorophe...)
Show SMILES COc1ccc([C@H]2CC(=O)NC[C@@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1S/C19H19ClFN3O3/c1-27-13-6-7-14(16(21)8-13)15-9-18(25)22-10-17(15)24-19(26)23-12-4-2-11(20)3-5-12/h2-8,15,17H,9-10H2,1H3,(H,22,25)(H2,23,24,26)/t15-,17+/m1/s1
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377293
PNG
(US10265310, Example 46 | ent2-1-(4-chlorophenyl)-3...)
Show SMILES COc1ccc([C@@H]2CCNC[C@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1/C19H21ClFN3O2/c1-26-14-6-7-15(17(21)10-14)16-8-9-22-11-18(16)24-19(25)23-13-4-2-12(20)3-5-13/h2-7,10,16,18,22H,8-9,11H2,1H3,(H2,23,24,25)/t16-,18+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377295
PNG
(US10265310, Example 48 | ent2-1-(4-(2,6-difluoro-4...)
Show SMILES COc1cc(F)c([C@@H]2CC(=O)NC[C@H]2NC(=O)Nc2ccncc2)c(F)c1
Show InChI InChI=1/C18H18F2N4O3/c1-27-11-6-13(19)17(14(20)7-11)12-8-16(25)22-9-15(12)24-18(26)23-10-2-4-21-5-3-10/h2-7,12,15H,8-9H2,1H3,(H,22,25)(H2,21,23,24,26)/t12-,15-/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377297
PNG
(US10265310, Example 50 | trans-ent2-1-(4-chlorophe...)
Show SMILES COc1cc(F)c([C@@H]2CC(=O)NC[C@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1S/C19H18ClF2N3O3/c1-28-12-6-14(21)18(15(22)7-12)13-8-17(26)23-9-16(13)25-19(27)24-11-4-2-10(20)3-5-11/h2-7,13,16H,8-9H2,1H3,(H,23,26)(H2,24,25,27)/t13-,16-/m1/s1
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377301
PNG
(US10265310, Example 54 | rrr)
Show SMILES COc1cc(F)c([C@@H]2CC(=O)NC[C@H]2NC(=O)Nc2ccc(Oc3ccccc3)cc2)c(F)c1
Show InChI InChI=1/C25H23F2N3O4/c1-33-18-11-20(26)24(21(27)12-18)19-13-23(31)28-14-22(19)30-25(32)29-15-7-9-17(10-8-15)34-16-5-3-2-4-6-16/h2-12,19,22H,13-14H2,1H3,(H,28,31)(H2,29,30,32)/t19-,22-/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377303
PNG
(US10265310, Example 56 | rrr)
Show SMILES COc1cc(F)c([C@@H]2CC(=O)NC[C@H]2NC(=O)Nc2ncc(Cl)s2)c(F)c1
Show InChI InChI=1/C16H15ClF2N4O3S/c1-26-7-2-9(18)14(10(19)3-7)8-4-13(24)20-5-11(8)22-15(25)23-16-21-6-12(17)27-16/h2-3,6,8,11H,4-5H2,1H3,(H,20,24)(H2,21,22,23,25)/t8-,11-/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377310
PNG
(US10265310, Example 63 | US10265310, Example 64 | ...)
Show SMILES COCCN1CC(NC(=O)Nc2ccc(Cl)cc2)C(CC1=O)c1ccc(F)cc1F
Show InChI InChI=1/C21H22ClF2N3O3/c1-30-9-8-27-12-19(26-21(29)25-15-5-2-13(22)3-6-15)17(11-20(27)28)16-7-4-14(23)10-18(16)24/h2-7,10,17,19H,8-9,11-12H2,1H3,(H2,25,26,29)
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377312
PNG
(US10265310, Example 65 | US10265310, Example 66 | ...)
Show SMILES FC(F)CN1CC(NC(=O)Nc2ccc(Cl)cc2)C(CC1=O)c1ccc(F)cc1F
Show InChI InChI=1/C20H18ClF4N3O2/c21-11-1-4-13(5-2-11)26-20(30)27-17-9-28(10-18(24)25)19(29)8-15(17)14-6-3-12(22)7-16(14)23/h1-7,15,17-18H,8-10H2,(H2,26,27,30)
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377319
PNG
(US10265310, Example 73 | rac-trans-1-(4-chlorophen...)
Show SMILES CCc1ccc(cc1)[C@H]1CC(=O)NC[C@@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1/C20H22ClN3O2/c1-2-13-3-5-14(6-4-13)17-11-19(25)22-12-18(17)24-20(26)23-16-9-7-15(21)8-10-16/h3-10,17-18H,2,11-12H2,1H3,(H,22,25)(H2,23,24,26)/t17-,18+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377329
PNG
(US10265310, Example 88 | rrr)
Show SMILES COc1cc(F)c(C2C(CCCN2C)NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1/C20H22ClF2N3O2/c1-26-9-3-4-17(25-20(27)24-13-7-5-12(21)6-8-13)19(26)18-15(22)10-14(28-2)11-16(18)23/h5-8,10-11,17,19H,3-4,9H2,1-2H3,(H2,24,25,27)
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377255
PNG
(US10265310, Example 1 | rac-trans-1-(4-chloropheny...)
Show SMILES COc1ccc(cc1)[C@H]1CC(=O)NC[C@@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1/C19H20ClN3O3/c1-26-15-8-2-12(3-9-15)16-10-18(24)21-11-17(16)23-19(25)22-14-6-4-13(20)5-7-14/h2-9,16-17H,10-11H2,1H3,(H,21,24)(H2,22,23,25)/t16-,17+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377257
PNG
(US10265310, Example 3 | rac-trans-1-(4-bromophenyl...)
Show SMILES COc1ccc(cc1)[C@H]1CC(=O)NC[C@@H]1NC(=O)Nc1ccc(Br)cc1
Show InChI InChI=1/C19H20BrN3O3/c1-26-15-8-2-12(3-9-15)16-10-18(24)21-11-17(16)23-19(25)22-14-6-4-13(20)5-7-14/h2-9,16-17H,10-11H2,1H3,(H,21,24)(H2,22,23,25)/t16-,17+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377257
PNG
(US10265310, Example 3 | rac-trans-1-(4-bromophenyl...)
Show SMILES COc1ccc(cc1)[C@H]1CC(=O)NC[C@@H]1NC(=O)Nc1ccc(Br)cc1
Show InChI InChI=1/C19H20BrN3O3/c1-26-15-8-2-12(3-9-15)16-10-18(24)21-11-17(16)23-19(25)22-14-6-4-13(20)5-7-14/h2-9,16-17H,10-11H2,1H3,(H,21,24)(H2,22,23,25)/t16-,17+/s2
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US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377261
PNG
(US10265310, Example 7 | rac-trans-1-(4-chloropheny...)
Show SMILES COc1ccc(cc1)[C@H]1CC(=O)N(C)C[C@@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1/C20H22ClN3O3/c1-24-12-18(23-20(26)22-15-7-5-14(21)6-8-15)17(11-19(24)25)13-3-9-16(27-2)10-4-13/h3-10,17-18H,11-12H2,1-2H3,(H2,22,23,26)/t17-,18+/s2
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US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377262
PNG
(US10265310, Example 8 | rac-trans-1-(4-bromophenyl...)
Show SMILES COc1cc(F)c([C@H]2CCNC[C@@H]2NC(=O)Nc2ccc(Br)cc2)c(F)c1
Show InChI InChI=1/C19H20BrF2N3O2/c1-27-13-8-15(21)18(16(22)9-13)14-6-7-23-10-17(14)25-19(26)24-12-4-2-11(20)3-5-12/h2-5,8-9,14,17,23H,6-7,10H2,1H3,(H2,24,25,26)/t14-,17-/s2
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US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377262
PNG
(US10265310, Example 8 | rac-trans-1-(4-bromophenyl...)
Show SMILES COc1cc(F)c([C@H]2CCNC[C@@H]2NC(=O)Nc2ccc(Br)cc2)c(F)c1
Show InChI InChI=1/C19H20BrF2N3O2/c1-27-13-8-15(21)18(16(22)9-13)14-6-7-23-10-17(14)25-19(26)24-12-4-2-11(20)3-5-12/h2-5,8-9,14,17,23H,6-7,10H2,1H3,(H2,24,25,26)/t14-,17-/s2
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US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377269
PNG
(US10265310, Example 15 | rac-trans-1-(4-chlorophen...)
Show SMILES COCCC(=O)N1CC[C@@H]([C@H](C1)NC(=O)Nc1ccc(Cl)cc1)c1ccc(OC)cc1
Show InChI InChI=1/C23H28ClN3O4/c1-30-14-12-22(28)27-13-11-20(16-3-9-19(31-2)10-4-16)21(15-27)26-23(29)25-18-7-5-17(24)6-8-18/h3-10,20-21H,11-15H2,1-2H3,(H2,25,26,29)/t20-,21+/s2
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US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377272
PNG
(US10265310, Example 18 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(Cl)cc1)C(=O)CC(C)C
Show InChI InChI=1/C24H30ClN3O3/c1-16(2)14-23(29)28-13-12-21(17-4-10-20(31-3)11-5-17)22(15-28)27-24(30)26-19-8-6-18(25)7-9-19/h4-11,16,21-22H,12-15H2,1-3H3,(H2,26,27,30)/t21-,22+/s2
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US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377274
PNG
(US10265310, Example 20 | rac-trans-2-(5-(3-(4-chlo...)
Show SMILES COc1ccc(cc1)[C@H]1CC(=O)N(CC(N)=O)C[C@@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1/C21H23ClN4O4/c1-30-16-8-2-13(3-9-16)17-10-20(28)26(12-19(23)27)11-18(17)25-21(29)24-15-6-4-14(22)5-7-15/h2-9,17-18H,10-12H2,1H3,(H2,23,27)(H2,24,25,29)/t17-,18+/s2
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US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377276
PNG
(US10265310, Example 23 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1cc(F)c([C@H]2CC(=O)NC[C@@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1/C19H18ClF2N3O3/c1-28-12-6-14(21)18(15(22)7-12)13-8-17(26)23-9-16(13)25-19(27)24-11-4-2-10(20)3-5-11/h2-7,13,16H,8-9H2,1H3,(H,23,26)(H2,24,25,27)/t13-,16-/s2
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US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377279
PNG
(US10265310, Example 26 | US10265310, Example 28 | ...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(C)nc1)C(C)=O
Show InChI InChI=1/C21H26N4O3/c1-14-4-7-17(12-22-14)23-21(27)24-20-13-25(15(2)26)11-10-19(20)16-5-8-18(28-3)9-6-16/h4-9,12,19-20H,10-11,13H2,1-3H3,(H2,23,24,27)/t19-,20+/s2
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US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377279
PNG
(US10265310, Example 26 | US10265310, Example 28 | ...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(C)nc1)C(C)=O
Show InChI InChI=1/C21H26N4O3/c1-14-4-7-17(12-22-14)23-21(27)24-20-13-25(15(2)26)11-10-19(20)16-5-8-18(28-3)9-6-16/h4-9,12,19-20H,10-11,13H2,1-3H3,(H2,23,24,27)/t19-,20+/s2
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US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377284
PNG
(US10265310, Example 31 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1cc(F)c([C@H]2CC(=O)N(CCO)C[C@@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1/C21H22ClF2N3O4/c1-31-14-8-16(23)20(17(24)9-14)15-10-19(29)27(6-7-28)11-18(15)26-21(30)25-13-4-2-12(22)3-5-13/h2-5,8-9,15,18,28H,6-7,10-11H2,1H3,(H2,25,26,30)/t15-,18-/s2
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US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377285
PNG
(US10265310, Example 32 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1ccc(cc1)[C@H]1CC(=O)N(CCO)C[C@@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1/C21H24ClN3O4/c1-29-17-8-2-14(3-9-17)18-12-20(27)25(10-11-26)13-19(18)24-21(28)23-16-6-4-15(22)5-7-16/h2-9,18-19,26H,10-13H2,1H3,(H2,23,24,28)/t18-,19+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377285
PNG
(US10265310, Example 32 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1ccc(cc1)[C@H]1CC(=O)N(CCO)C[C@@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1/C21H24ClN3O4/c1-29-17-8-2-14(3-9-17)18-12-20(27)25(10-11-26)13-19(18)24-21(28)23-16-6-4-15(22)5-7-16/h2-9,18-19,26H,10-13H2,1H3,(H2,23,24,28)/t18-,19+/s2
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US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377286
PNG
(US10265310, Example 36 | trans-ent1-1-(4-chlorophe...)
Show SMILES COc1cc(F)c([C@H]2CCNC[C@@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1S/C19H20ClF2N3O2/c1-27-13-8-15(21)18(16(22)9-13)14-6-7-23-10-17(14)25-19(26)24-12-4-2-11(20)3-5-12/h2-5,8-9,14,17,23H,6-7,10H2,1H3,(H2,24,25,26)/t14-,17-/m0/s1
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US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377296
PNG
(US10265310, Example 49 | trans-ent1-1-(4-chlorophe...)
Show SMILES COc1cc(F)c([C@H]2CC(=O)NC[C@@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1S/C19H18ClF2N3O3/c1-28-12-6-14(21)18(15(22)7-12)13-8-17(26)23-9-16(13)25-19(27)24-11-4-2-10(20)3-5-11/h2-7,13,16H,8-9H2,1H3,(H,23,26)(H2,24,25,27)/t13-,16-/m0/s1
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377299
PNG
(US10265310, Example 52 | rrr)
Show SMILES COc1cc(F)c([C@@H]2CC(=O)NC[C@H]2NC(=O)Nc2csc(Cl)c2)c(F)c1
Show InChI InChI=1/C17H16ClF2N3O3S/c1-26-9-3-11(19)16(12(20)4-9)10-5-15(24)21-6-13(10)23-17(25)22-8-2-14(18)27-7-8/h2-4,7,10,13H,5-6H2,1H3,(H,21,24)(H2,22,23,25)/t10-,13-/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377302
PNG
(US10265310, Example 55 | rrr)
Show SMILES COc1cc(F)c([C@@H]2CC(=O)NC[C@H]2NC(=O)Nc2cc(C)ns2)c(F)c1
Show InChI InChI=1/C17H18F2N4O3S/c1-8-3-15(27-23-8)22-17(25)21-13-7-20-14(24)6-10(13)16-11(18)4-9(26-2)5-12(16)19/h3-5,10,13H,6-7H2,1-2H3,(H,20,24)(H2,21,22,25)/t10-,13-/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377310
PNG
(US10265310, Example 63 | US10265310, Example 64 | ...)
Show SMILES COCCN1CC(NC(=O)Nc2ccc(Cl)cc2)C(CC1=O)c1ccc(F)cc1F
Show InChI InChI=1/C21H22ClF2N3O3/c1-30-9-8-27-12-19(26-21(29)25-15-5-2-13(22)3-6-15)17(11-20(27)28)16-7-4-14(23)10-18(16)24/h2-7,10,17,19H,8-9,11-12H2,1H3,(H2,25,26,29)
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377312
PNG
(US10265310, Example 65 | US10265310, Example 66 | ...)
Show SMILES FC(F)CN1CC(NC(=O)Nc2ccc(Cl)cc2)C(CC1=O)c1ccc(F)cc1F
Show InChI InChI=1/C20H18ClF4N3O2/c21-11-1-4-13(5-2-11)26-20(30)27-17-9-28(10-18(24)25)19(29)8-15(17)14-6-3-12(22)7-16(14)23/h1-7,15,17-18H,8-10H2,(H2,26,27,30)
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377314
PNG
(US10265310, Example 67 | US10265310, Example 68 | ...)
Show SMILES Fc1ccc(C2CC(=O)NCC2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1/C18H16ClF2N3O2/c19-10-1-4-12(5-2-10)23-18(26)24-16-9-22-17(25)8-14(16)13-6-3-11(20)7-15(13)21/h1-7,14,16H,8-9H2,(H,22,25)(H2,23,24,26)
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377314
PNG
(US10265310, Example 67 | US10265310, Example 68 | ...)
Show SMILES Fc1ccc(C2CC(=O)NCC2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1/C18H16ClF2N3O2/c19-10-1-4-12(5-2-10)23-18(26)24-16-9-22-17(25)8-14(16)13-6-3-11(20)7-15(13)21/h1-7,14,16H,8-9H2,(H,22,25)(H2,23,24,26)
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377316
PNG
(US10265310, Example 69 | rac-trans-1-(4-chlorophen...)
Show SMILES CCc1cc(F)c([C@H]2CC(=O)NC[C@@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1/C20H20ClF2N3O2/c1-2-11-7-15(22)19(16(23)8-11)14-9-18(27)24-10-17(14)26-20(28)25-13-5-3-12(21)4-6-13/h3-8,14,17H,2,9-10H2,1H3,(H,24,27)(H2,25,26,28)/t14-,17-/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377317
PNG
(US10265310, Example 70 | rac-trans-1-(4-chlorophen...)
Show SMILES FC(F)Oc1cc(F)c([C@H]2CC(=O)NC[C@@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1/C19H16ClF4N3O3/c20-9-1-3-10(4-2-9)26-19(29)27-15-8-25-16(28)7-12(15)17-13(21)5-11(6-14(17)22)30-18(23)24/h1-6,12,15,18H,7-8H2,(H,25,28)(H2,26,27,29)/t12-,15-/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377319
PNG
(US10265310, Example 73 | rac-trans-1-(4-chlorophen...)
Show SMILES CCc1ccc(cc1)[C@H]1CC(=O)NC[C@@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1/C20H22ClN3O2/c1-2-13-3-5-14(6-4-13)17-11-19(25)22-12-18(17)24-20(26)23-16-9-7-15(21)8-10-16/h3-10,17-18H,2,11-12H2,1H3,(H,22,25)(H2,23,24,26)/t17-,18+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377326
PNG
(US10265310, Example 83 | trans-ent1-1-(4-chlorophe...)
Show SMILES Clc1ccc(NC(=O)N[C@H]2CN(CC[C@@H]2c2ccccc2)C(=O)C2CC2)cc1
Show InChI InChI=1S/C22H24ClN3O2/c23-17-8-10-18(11-9-17)24-22(28)25-20-14-26(21(27)16-6-7-16)13-12-19(20)15-4-2-1-3-5-15/h1-5,8-11,16,19-20H,6-7,12-14H2,(H2,24,25,28)/t19-,20+/m1/s1
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377328
PNG
(US10265310, Example 86 | trans-ent1-1-(4-chlorophe...)
Show SMILES COc1ccc([C@H]2CCN(C[C@@H]2NC(=O)Nc2ccc(Cl)cc2)C(=O)C2CC2)c(F)c1
Show InChI InChI=1S/C23H25ClFN3O3/c1-31-17-8-9-18(20(25)12-17)19-10-11-28(22(29)14-2-3-14)13-21(19)27-23(30)26-16-6-4-15(24)5-7-16/h4-9,12,14,19,21H,2-3,10-11,13H2,1H3,(H2,26,27,30)/t19-,21+/m1/s1
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377330
PNG
(US10265310, Example 89 | US10265310, Example 90 | ...)
Show SMILES COc1ccc(cc1)C1C(CCCN1C)NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1/C20H24ClN3O2/c1-24-13-3-4-18(19(24)14-5-11-17(26-2)12-6-14)23-20(25)22-16-9-7-15(21)8-10-16/h5-12,18-19H,3-4,13H2,1-2H3,(H2,22,23,25)
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377332
PNG
(US10265310, Example 91 | rrr)
Show SMILES Clc1ccc(NC(=O)NC2CNC(=O)CC2c2ccc(Cl)cc2)cc1
Show InChI InChI=1/C18H17Cl2N3O2/c19-12-3-1-11(2-4-12)15-9-17(24)21-10-16(15)23-18(25)22-14-7-5-13(20)6-8-14/h1-8,15-16H,9-10H2,(H,21,24)(H2,22,23,25)
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377268
PNG
(US10265310, Example 14 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(Cl)cc1)C(=O)C(C)(F)F
Show InChI InChI=1/C22H24ClF2N3O3/c1-22(24,25)20(29)28-12-11-18(14-3-9-17(31-2)10-4-14)19(13-28)27-21(30)26-16-7-5-15(23)6-8-16/h3-10,18-19H,11-13H2,1-2H3,(H2,26,27,30)/t18-,19+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377277
PNG
(US10265310, Example 24 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1ccc(cc1)[C@H]1CC(=O)N(CC2CC2)C[C@@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1/C23H26ClN3O3/c1-30-19-10-4-16(5-11-19)20-12-22(28)27(13-15-2-3-15)14-21(20)26-23(29)25-18-8-6-17(24)7-9-18/h4-11,15,20-21H,2-3,12-14H2,1H3,(H2,25,26,29)/t20-,21+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377279
PNG
(US10265310, Example 26 | US10265310, Example 28 | ...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(C)nc1)C(C)=O
Show InChI InChI=1/C21H26N4O3/c1-14-4-7-17(12-22-14)23-21(27)24-20-13-25(15(2)26)11-10-19(20)16-5-8-18(28-3)9-6-16/h4-9,12,19-20H,10-11,13H2,1-3H3,(H2,23,24,27)/t19-,20+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377282
PNG
(US10265310, Example 29 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1cc(F)c([C@H]2CC(=O)N(CC3CC3)C[C@@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1/C23H24ClF2N3O3/c1-32-16-8-18(25)22(19(26)9-16)17-10-21(30)29(11-13-2-3-13)12-20(17)28-23(31)27-15-6-4-14(24)5-7-15/h4-9,13,17,20H,2-3,10-12H2,1H3,(H2,27,28,31)/t17-,20-/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377287
PNG
(US10265310, Example 37 | trans-ent2-1-(4-chlorophe...)
Show SMILES COc1cc(F)c([C@@H]2CCNC[C@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1S/C19H20ClF2N3O2/c1-27-13-8-15(21)18(16(22)9-13)14-6-7-23-10-17(14)25-19(26)24-12-4-2-11(20)3-5-12/h2-5,8-9,14,17,23H,6-7,10H2,1H3,(H2,24,25,26)/t14-,17-/m1/s1
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377288
PNG
(US10265310, Example 39 | trans-ent1-1-(4-chlorophe...)
Show SMILES COc1cc(F)c([C@H]2CCN(C[C@@H]2NC(=O)Nc2ccc(Cl)cc2)C(=O)C2CC2)c(F)c1
Show InChI InChI=1S/C23H24ClF2N3O3/c1-32-16-10-18(25)21(19(26)11-16)17-8-9-29(22(30)13-2-3-13)12-20(17)28-23(31)27-15-6-4-14(24)5-7-15/h4-7,10-11,13,17,20H,2-3,8-9,12H2,1H3,(H2,27,28,31)/t17-,20-/m0/s1
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377288
PNG
(US10265310, Example 39 | trans-ent1-1-(4-chlorophe...)
Show SMILES COc1cc(F)c([C@H]2CCN(C[C@@H]2NC(=O)Nc2ccc(Cl)cc2)C(=O)C2CC2)c(F)c1
Show InChI InChI=1S/C23H24ClF2N3O3/c1-32-16-10-18(25)21(19(26)11-16)17-8-9-29(22(30)13-2-3-13)12-20(17)28-23(31)27-15-6-4-14(24)5-7-15/h4-7,10-11,13,17,20H,2-3,8-9,12H2,1H3,(H2,27,28,31)/t17-,20-/m0/s1
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377293
PNG
(US10265310, Example 46 | ent2-1-(4-chlorophenyl)-3...)
Show SMILES COc1ccc([C@@H]2CCNC[C@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1/C19H21ClFN3O2/c1-26-14-6-7-15(17(21)10-14)16-8-9-22-11-18(16)24-19(25)23-13-4-2-12(20)3-5-13/h2-7,10,16,18,22H,8-9,11H2,1H3,(H2,23,24,25)/t16-,18+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377304
PNG
(US10265310, Example 57 | rrr)
Show SMILES COc1cc(F)c([C@@H]2CC(=O)NC[C@H]2NC(=O)Nc2ccc(Cl)c(O)c2)c(F)c1
Show InChI InChI=1/C19H18ClF2N3O4/c1-29-10-5-13(21)18(14(22)6-10)11-7-17(27)23-8-15(11)25-19(28)24-9-2-3-12(20)16(26)4-9/h2-6,11,15,26H,7-8H2,1H3,(H,23,27)(H2,24,25,28)/t11-,15-/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377305
PNG
(US10265310, Example 58 | rrr)
Show SMILES COc1cc(F)c([C@@H]2CC(=O)NC[C@H]2NC(=O)Nc2ccc(Cl)c(F)c2)c(F)c1
Show InChI InChI=1/C19H17ClF3N3O3/c1-29-10-5-14(22)18(15(23)6-10)11-7-17(27)24-8-16(11)26-19(28)25-9-2-3-12(20)13(21)4-9/h2-6,11,16H,7-8H2,1H3,(H,24,27)(H2,25,26,28)/t11-,16-/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377308
PNG
(US10265310, Example 61 | US10265310, Example 62 | ...)
Show SMILES COc1ccc(C2CC(=O)N(CC(F)F)CC2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1/C21H21ClF3N3O3/c1-31-14-6-7-15(17(23)8-14)16-9-20(29)28(11-19(24)25)10-18(16)27-21(30)26-13-4-2-12(22)3-5-13/h2-8,16,18-19H,9-11H2,1H3,(H2,26,27,30)
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377312
PNG
(US10265310, Example 65 | US10265310, Example 66 | ...)
Show SMILES FC(F)CN1CC(NC(=O)Nc2ccc(Cl)cc2)C(CC1=O)c1ccc(F)cc1F
Show InChI InChI=1/C20H18ClF4N3O2/c21-11-1-4-13(5-2-11)26-20(30)27-17-9-28(10-18(24)25)19(29)8-15(17)14-6-3-12(22)7-16(14)23/h1-7,15,17-18H,8-10H2,(H2,26,27,30)
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377314
PNG
(US10265310, Example 67 | US10265310, Example 68 | ...)
Show SMILES Fc1ccc(C2CC(=O)NCC2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1/C18H16ClF2N3O2/c19-10-1-4-12(5-2-10)23-18(26)24-16-9-22-17(25)8-14(16)13-6-3-11(20)7-15(13)21/h1-7,14,16H,8-9H2,(H,22,25)(H2,23,24,26)
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377320
PNG
(US10265310, Example 74 | rac-trans-1-(4-chlorophen...)
Show SMILES FC(F)Oc1ccc(cc1)[C@H]1CC(=O)NC[C@@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1/C19H18ClF2N3O3/c20-12-3-5-13(6-4-12)24-19(27)25-16-10-23-17(26)9-15(16)11-1-7-14(8-2-11)28-18(21)22/h1-8,15-16,18H,9-10H2,(H,23,26)(H2,24,25,27)/t15-,16+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377321
PNG
(US10265310, Example 75 | rac-trans-1-(4-chlorophen...)
Show SMILES CS(=O)(=O)c1ccc(cc1)[C@H]1CC(=O)NC[C@@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1/C19H20ClN3O4S/c1-28(26,27)15-8-2-12(3-9-15)16-10-18(24)21-11-17(16)23-19(25)22-14-6-4-13(20)5-7-14/h2-9,16-17H,10-11H2,1H3,(H,21,24)(H2,22,23,25)/t16-,17+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377332
PNG
(US10265310, Example 91 | rrr)
Show SMILES Clc1ccc(NC(=O)NC2CNC(=O)CC2c2ccc(Cl)cc2)cc1
Show InChI InChI=1/C18H17Cl2N3O2/c19-12-3-1-11(2-4-12)15-9-17(24)21-10-16(15)23-18(25)22-14-7-5-13(20)6-8-14/h1-8,15-16H,9-10H2,(H,21,24)(H2,22,23,25)
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377256
PNG
(US10265310, Example 2 | rac-trans-1-(1-acetyl-4-(4...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(Cl)cc1)C(C)=O
Show InChI InChI=1/C21H24ClN3O3/c1-14(26)25-12-11-19(15-3-9-18(28-2)10-4-15)20(13-25)24-21(27)23-17-7-5-16(22)6-8-17/h3-10,19-20H,11-13H2,1-2H3,(H2,23,24,27)/t19-,20+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377258
PNG
(US10265310, Example 4 | rac-trans-1-(4-chloropheny...)
Show SMILES COc1ccc(cc1)[C@H]1CCNC[C@@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1/C19H22ClN3O2/c1-25-16-8-2-13(3-9-16)17-10-11-21-12-18(17)23-19(24)22-15-6-4-14(20)5-7-15/h2-9,17-18,21H,10-12H2,1H3,(H2,22,23,24)/t17-,18+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377261
PNG
(US10265310, Example 7 | rac-trans-1-(4-chloropheny...)
Show SMILES COc1ccc(cc1)[C@H]1CC(=O)N(C)C[C@@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1/C20H22ClN3O3/c1-24-12-18(23-20(26)22-15-7-5-14(21)6-8-15)17(11-19(24)25)13-3-9-16(27-2)10-4-13/h3-10,17-18H,11-12H2,1-2H3,(H2,22,23,26)/t17-,18+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377263
PNG
(US10265310, Example 9 | rac-trans-1-(4-chloropheny...)
Show SMILES COc1cc(F)c([C@H]2CCNC[C@@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1/C19H20ClF2N3O2/c1-27-13-8-15(21)18(16(22)9-13)14-6-7-23-10-17(14)25-19(26)24-12-4-2-11(20)3-5-12/h2-5,8-9,14,17,23H,6-7,10H2,1H3,(H2,24,25,26)/t14-,17-/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377268
PNG
(US10265310, Example 14 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(Cl)cc1)C(=O)C(C)(F)F
Show InChI InChI=1/C22H24ClF2N3O3/c1-22(24,25)20(29)28-12-11-18(14-3-9-17(31-2)10-4-14)19(13-28)27-21(30)26-16-7-5-15(23)6-8-16/h3-10,18-19H,11-13H2,1-2H3,(H2,26,27,30)/t18-,19+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377272
PNG
(US10265310, Example 18 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(Cl)cc1)C(=O)CC(C)C
Show InChI InChI=1/C24H30ClN3O3/c1-16(2)14-23(29)28-13-12-21(17-4-10-20(31-3)11-5-17)22(15-28)27-24(30)26-19-8-6-18(25)7-9-19/h4-11,16,21-22H,12-15H2,1-3H3,(H2,26,27,30)/t21-,22+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377273
PNG
(US10265310, Example 19 | rac-trans-1-(1-acetyl-4-(...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(Cl)nc1)C(C)=O
Show InChI InChI=1/C20H23ClN4O3/c1-13(26)25-10-9-17(14-3-6-16(28-2)7-4-14)18(12-25)24-20(27)23-15-5-8-19(21)22-11-15/h3-8,11,17-18H,9-10,12H2,1-2H3,(H2,23,24,27)/t17-,18+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377280
PNG
(US10265310, Example 27 | rac-trans-1-(1-acetyl-4-(...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(nc1)C(F)(F)F)C(C)=O
Show InChI InChI=1/C21H23F3N4O3/c1-13(29)28-10-9-17(14-3-6-16(31-2)7-4-14)18(12-28)27-20(30)26-15-5-8-19(25-11-15)21(22,23)24/h3-8,11,17-18H,9-10,12H2,1-2H3,(H2,26,27,30)/t17-,18+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377290
PNG
(US10265310, Example 42 | trans-ent1-1-(4-chlorophe...)
Show SMILES COc1ccc([C@H]2CC(=O)NC[C@@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1S/C19H19ClFN3O3/c1-27-13-6-7-14(16(21)8-13)15-9-18(25)22-10-17(15)24-19(26)23-12-4-2-11(20)3-5-12/h2-8,15,17H,9-10H2,1H3,(H,22,25)(H2,23,24,26)/t15-,17+/m1/s1
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377291
PNG
(US10265310, Example 43 | trans-ent2-1-(4-chlorophe...)
Show SMILES COc1ccc([C@@H]2CC(=O)NC[C@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1S/C19H19ClFN3O3/c1-27-13-6-7-14(16(21)8-13)15-9-18(25)22-10-17(15)24-19(26)23-12-4-2-11(20)3-5-12/h2-8,15,17H,9-10H2,1H3,(H,22,25)(H2,23,24,26)/t15-,17+/m0/s1
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377294
PNG
(US10265310, Example 47 | ent1-1-(4-(2,6-difluoro-4...)
Show SMILES COc1cc(F)c([C@H]2CC(=O)NC[C@@H]2NC(=O)Nc2ccncc2)c(F)c1
Show InChI InChI=1/C18H18F2N4O3/c1-27-11-6-13(19)17(14(20)7-11)12-8-16(25)22-9-15(12)24-18(26)23-10-2-4-21-5-3-10/h2-7,12,15H,8-9H2,1H3,(H,22,25)(H2,21,23,24,26)/t12-,15-/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377294
PNG
(US10265310, Example 47 | ent1-1-(4-(2,6-difluoro-4...)
Show SMILES COc1cc(F)c([C@H]2CC(=O)NC[C@@H]2NC(=O)Nc2ccncc2)c(F)c1
Show InChI InChI=1/C18H18F2N4O3/c1-27-11-6-13(19)17(14(20)7-11)12-8-16(25)22-9-15(12)24-18(26)23-10-2-4-21-5-3-10/h2-7,12,15H,8-9H2,1H3,(H,22,25)(H2,21,23,24,26)/t12-,15-/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377295
PNG
(US10265310, Example 48 | ent2-1-(4-(2,6-difluoro-4...)
Show SMILES COc1cc(F)c([C@@H]2CC(=O)NC[C@H]2NC(=O)Nc2ccncc2)c(F)c1
Show InChI InChI=1/C18H18F2N4O3/c1-27-11-6-13(19)17(14(20)7-11)12-8-16(25)22-9-15(12)24-18(26)23-10-2-4-21-5-3-10/h2-7,12,15H,8-9H2,1H3,(H,22,25)(H2,21,23,24,26)/t12-,15-/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377300
PNG
(US10265310, Example 53 | rrr)
Show SMILES COc1cc(F)c([C@@H]2CC(=O)NC[C@H]2NC(=O)Nc2cc3ccccc3s2)c(F)c1
Show InChI InChI=1/C21H19F2N3O3S/c1-29-12-7-14(22)20(15(23)8-12)13-9-18(27)24-10-16(13)25-21(28)26-19-6-11-4-2-3-5-17(11)30-19/h2-8,13,16H,9-10H2,1H3,(H,24,27)(H2,25,26,28)/t13-,16-/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377306
PNG
(US10265310, Example 59 | US10265310, Example 60 | ...)
Show SMILES COCCN1CC(NC(=O)Nc2ccc(Cl)cc2)C(CC1=O)c1ccc(OC)cc1F
Show InChI InChI=1/C22H25ClFN3O4/c1-30-10-9-27-13-20(26-22(29)25-15-5-3-14(23)4-6-15)18(12-21(27)28)17-8-7-16(31-2)11-19(17)24/h3-8,11,18,20H,9-10,12-13H2,1-2H3,(H2,25,26,29)
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377306
PNG
(US10265310, Example 59 | US10265310, Example 60 | ...)
Show SMILES COCCN1CC(NC(=O)Nc2ccc(Cl)cc2)C(CC1=O)c1ccc(OC)cc1F
Show InChI InChI=1/C22H25ClFN3O4/c1-30-10-9-27-13-20(26-22(29)25-15-5-3-14(23)4-6-15)18(12-21(27)28)17-8-7-16(31-2)11-19(17)24/h3-8,11,18,20H,9-10,12-13H2,1-2H3,(H2,25,26,29)
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377308
PNG
(US10265310, Example 61 | US10265310, Example 62 | ...)
Show SMILES COc1ccc(C2CC(=O)N(CC(F)F)CC2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1/C21H21ClF3N3O3/c1-31-14-6-7-15(17(23)8-14)16-9-20(29)28(11-19(24)25)10-18(16)27-21(30)26-13-4-2-12(22)3-5-13/h2-8,16,18-19H,9-11H2,1H3,(H2,26,27,30)
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GrÜNENTHAL GMBH

US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377316
PNG
(US10265310, Example 69 | rac-trans-1-(4-chlorophen...)
Show SMILES CCc1cc(F)c([C@H]2CC(=O)NC[C@@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1/C20H20ClF2N3O2/c1-2-11-7-15(22)19(16(23)8-11)14-9-18(27)24-10-17(14)26-20(28)25-13-5-3-12(21)4-6-13/h3-8,14,17H,2,9-10H2,1H3,(H,24,27)(H2,25,26,28)/t14-,17-/s2
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US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377321
PNG
(US10265310, Example 75 | rac-trans-1-(4-chlorophen...)
Show SMILES CS(=O)(=O)c1ccc(cc1)[C@H]1CC(=O)NC[C@@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1/C19H20ClN3O4S/c1-28(26,27)15-8-2-12(3-9-15)16-10-18(24)21-11-17(16)23-19(25)22-14-6-4-13(20)5-7-14/h2-9,16-17H,10-11H2,1H3,(H,21,24)(H2,22,23,25)/t16-,17+/s2
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US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377322
PNG
(US10265310, Example 76 | trans-ent1-1-(4-chlorophe...)
Show SMILES COc1ccc(cc1)[C@H]1CC(=O)NC[C@@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C19H20ClN3O3/c1-26-15-8-2-12(3-9-15)16-10-18(24)21-11-17(16)23-19(25)22-14-6-4-13(20)5-7-14/h2-9,16-17H,10-11H2,1H3,(H,21,24)(H2,22,23,25)/t16-,17+/m1/s1
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US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377324
PNG
(US10265310, Example 80 | trans-ent1-1-(4-chlorophe...)
Show SMILES Clc1ccc(NC(=O)N[C@H]2CNCC[C@@H]2c2ccccc2)cc1
Show InChI InChI=1S/C18H20ClN3O/c19-14-6-8-15(9-7-14)21-18(23)22-17-12-20-11-10-16(17)13-4-2-1-3-5-13/h1-9,16-17,20H,10-12H2,(H2,21,22,23)/t16-,17+/m1/s1
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US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377324
PNG
(US10265310, Example 80 | trans-ent1-1-(4-chlorophe...)
Show SMILES Clc1ccc(NC(=O)N[C@H]2CNCC[C@@H]2c2ccccc2)cc1
Show InChI InChI=1S/C18H20ClN3O/c19-14-6-8-15(9-7-14)21-18(23)22-17-12-20-11-10-16(17)13-4-2-1-3-5-13/h1-9,16-17,20H,10-12H2,(H2,21,22,23)/t16-,17+/m1/s1
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US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377327
PNG
(US10265310, Example 84 | trans-ent2-1-(4-chlorophe...)
Show SMILES Clc1ccc(NC(=O)N[C@@H]2CN(CC[C@H]2c2ccccc2)C(=O)C2CC2)cc1
Show InChI InChI=1S/C22H24ClN3O2/c23-17-8-10-18(11-9-17)24-22(28)25-20-14-26(21(27)16-6-7-16)13-12-19(20)15-4-2-1-3-5-15/h1-5,8-11,16,19-20H,6-7,12-14H2,(H2,24,25,28)/t19-,20+/m0/s1
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US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377330
PNG
(US10265310, Example 89 | US10265310, Example 90 | ...)
Show SMILES COc1ccc(cc1)C1C(CCCN1C)NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1/C20H24ClN3O2/c1-24-13-3-4-18(19(24)14-5-11-17(26-2)12-6-14)23-20(25)22-16-9-7-15(21)8-10-16/h5-12,18-19H,3-4,13H2,1-2H3,(H2,22,23,25)
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US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377270
PNG
(US10265310, Example 16 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(Cl)cc1)C(=O)C1CCOCC1
Show InChI InChI=1/C25H30ClN3O4/c1-32-21-8-2-17(3-9-21)22-10-13-29(24(30)18-11-14-33-15-12-18)16-23(22)28-25(31)27-20-6-4-19(26)5-7-20/h2-9,18,22-23H,10-16H2,1H3,(H2,27,28,31)/t22-,23+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377255
PNG
(US10265310, Example 1 | rac-trans-1-(4-chloropheny...)
Show SMILES COc1ccc(cc1)[C@H]1CC(=O)NC[C@@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1/C19H20ClN3O3/c1-26-15-8-2-12(3-9-15)16-10-18(24)21-11-17(16)23-19(25)22-14-6-4-13(20)5-7-14/h2-9,16-17H,10-11H2,1H3,(H,21,24)(H2,22,23,25)/t16-,17+/s2
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US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377259
PNG
(US10265310, Example 5 | rac-trans-1-(1-acetyl-4-(2...)
Show SMILES COc1cc(F)c([C@H]2CCN(C[C@@H]2NC(=O)Nc2ccc(Cl)cc2)C(C)=O)c(F)c1
Show InChI InChI=1/C21H22ClF2N3O3/c1-12(28)27-8-7-16(20-17(23)9-15(30-2)10-18(20)24)19(11-27)26-21(29)25-14-5-3-13(22)4-6-14/h3-6,9-10,16,19H,7-8,11H2,1-2H3,(H2,25,26,29)/t16-,19-/s2
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US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377271
PNG
(US10265310, Example 17 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(Cl)cc1)C(=O)C(C)C
Show InChI InChI=1/C23H28ClN3O3/c1-15(2)22(28)27-13-12-20(16-4-10-19(30-3)11-5-16)21(14-27)26-23(29)25-18-8-6-17(24)7-9-18/h4-11,15,20-21H,12-14H2,1-3H3,(H2,25,26,29)/t20-,21+/s2
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US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377279
PNG
(US10265310, Example 26 | US10265310, Example 28 | ...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(C)nc1)C(C)=O
Show InChI InChI=1/C21H26N4O3/c1-14-4-7-17(12-22-14)23-21(27)24-20-13-25(15(2)26)11-10-19(20)16-5-8-18(28-3)9-6-16/h4-9,12,19-20H,10-11,13H2,1-3H3,(H2,23,24,27)/t19-,20+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377298
PNG
(US10265310, Example 51 | rac-trans-1-(5-chlorothio...)
Show SMILES COc1cc(F)c([C@H]2CC(=O)NC[C@@H]2NC(=O)Nc2ccc(Cl)s2)c(F)c1
Show InChI InChI=1/C17H16ClF2N3O3S/c1-26-8-4-10(19)16(11(20)5-8)9-6-14(24)21-7-12(9)22-17(25)23-15-3-2-13(18)27-15/h2-5,9,12H,6-7H2,1H3,(H,21,24)(H2,22,23,25)/t9-,12-/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377300
PNG
(US10265310, Example 53 | rrr)
Show SMILES COc1cc(F)c([C@@H]2CC(=O)NC[C@H]2NC(=O)Nc2cc3ccccc3s2)c(F)c1
Show InChI InChI=1/C21H19F2N3O3S/c1-29-12-7-14(22)20(15(23)8-12)13-9-18(27)24-10-16(13)25-21(28)26-19-6-11-4-2-3-5-17(11)30-19/h2-8,13,16H,9-10H2,1H3,(H,24,27)(H2,25,26,28)/t13-,16-/s2
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US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377306
PNG
(US10265310, Example 59 | US10265310, Example 60 | ...)
Show SMILES COCCN1CC(NC(=O)Nc2ccc(Cl)cc2)C(CC1=O)c1ccc(OC)cc1F
Show InChI InChI=1/C22H25ClFN3O4/c1-30-10-9-27-13-20(26-22(29)25-15-5-3-14(23)4-6-15)18(12-21(27)28)17-8-7-16(31-2)11-19(17)24/h3-8,11,18,20H,9-10,12-13H2,1-2H3,(H2,25,26,29)
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377317
PNG
(US10265310, Example 70 | rac-trans-1-(4-chlorophen...)
Show SMILES FC(F)Oc1cc(F)c([C@H]2CC(=O)NC[C@@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1/C19H16ClF4N3O3/c20-9-1-3-10(4-2-9)26-19(29)27-15-8-25-16(28)7-12(15)17-13(21)5-11(6-14(17)22)30-18(23)24/h1-6,12,15,18H,7-8H2,(H,25,28)(H2,26,27,29)/t12-,15-/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377318
PNG
(US10265310, Example 72 | rac-trans-1-(4-chlorophen...)
Show SMILES CSc1ccc(cc1)[C@H]1CC(=O)NC[C@@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1/C19H20ClN3O2S/c1-26-15-8-2-12(3-9-15)16-10-18(24)21-11-17(16)23-19(25)22-14-6-4-13(20)5-7-14/h2-9,16-17H,10-11H2,1H3,(H,21,24)(H2,22,23,25)/t16-,17+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377325
PNG
(US10265310, Example 81 | trans-ent2-1-(4-chlorophe...)
Show SMILES Clc1ccc(NC(=O)N[C@@H]2CNCC[C@H]2c2ccccc2)cc1
Show InChI InChI=1S/C18H20ClN3O/c19-14-6-8-15(9-7-14)21-18(23)22-17-12-20-11-10-16(17)13-4-2-1-3-5-13/h1-9,16-17,20H,10-12H2,(H2,21,22,23)/t16-,17+/m0/s1
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377264
PNG
(US10265310, Example 10 | trans-ent1-(4-chloropheny...)
Show SMILES COc1ccc(cc1)[C@H]1CC(=O)N(C)C[C@@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C20H22ClN3O3/c1-24-12-18(23-20(26)22-15-7-5-14(21)6-8-15)17(11-19(24)25)13-3-9-16(27-2)10-4-13/h3-10,17-18H,11-12H2,1-2H3,(H2,22,23,26)/t17-,18+/m1/s1
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377267
PNG
(US10265310, Example 13 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(Cl)cc1)C(=O)CO
Show InChI InChI=1/C21H24ClN3O4/c1-29-17-8-2-14(3-9-17)18-10-11-25(20(27)13-26)12-19(18)24-21(28)23-16-6-4-15(22)5-7-16/h2-9,18-19,26H,10-13H2,1H3,(H2,23,24,28)/t18-,19+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377275
PNG
(US10265310, Example 21 | rac-trans-methyl 2-(5-(3-...)
Show SMILES COC(=O)CN1C[C@H](NC(=O)Nc2ccc(Cl)cc2)[C@H](CC1=O)c1ccc(OC)cc1
Show InChI InChI=1S/C22H24ClN3O5/c1-30-17-9-3-14(4-10-17)18-11-20(27)26(13-21(28)31-2)12-19(18)25-22(29)24-16-7-5-15(23)6-8-16/h3-10,18-19H,11-13H2,1-2H3,(H2,24,25,29)/t18-,19+/m1/s1
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377275
PNG
(US10265310, Example 21 | rac-trans-methyl 2-(5-(3-...)
Show SMILES COC(=O)CN1C[C@H](NC(=O)Nc2ccc(Cl)cc2)[C@H](CC1=O)c1ccc(OC)cc1
Show InChI InChI=1S/C22H24ClN3O5/c1-30-17-9-3-14(4-10-17)18-11-20(27)26(13-21(28)31-2)12-19(18)25-22(29)24-16-7-5-15(23)6-8-16/h3-10,18-19H,11-13H2,1-2H3,(H2,24,25,29)/t18-,19+/m1/s1
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377276
PNG
(US10265310, Example 23 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1cc(F)c([C@H]2CC(=O)NC[C@@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1/C19H18ClF2N3O3/c1-28-12-6-14(21)18(15(22)7-12)13-8-17(26)23-9-16(13)25-19(27)24-11-4-2-10(20)3-5-11/h2-7,13,16H,8-9H2,1H3,(H,23,26)(H2,24,25,27)/t13-,16-/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377289
PNG
(US10265310, Example 40 | trans-ent2-1-(4-chlorophe...)
Show SMILES COc1cc(F)c([C@@H]2CCN(C[C@H]2NC(=O)Nc2ccc(Cl)cc2)C(=O)C2CC2)c(F)c1
Show InChI InChI=1S/C23H24ClF2N3O3/c1-32-16-10-18(25)21(19(26)11-16)17-8-9-29(22(30)13-2-3-13)12-20(17)28-23(31)27-15-6-4-14(24)5-7-15/h4-7,10-11,13,17,20H,2-3,8-9,12H2,1H3,(H2,27,28,31)/t17-,20-/m1/s1
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377289
PNG
(US10265310, Example 40 | trans-ent2-1-(4-chlorophe...)
Show SMILES COc1cc(F)c([C@@H]2CCN(C[C@H]2NC(=O)Nc2ccc(Cl)cc2)C(=O)C2CC2)c(F)c1
Show InChI InChI=1S/C23H24ClF2N3O3/c1-32-16-10-18(25)21(19(26)11-16)17-8-9-29(22(30)13-2-3-13)12-20(17)28-23(31)27-15-6-4-14(24)5-7-15/h4-7,10-11,13,17,20H,2-3,8-9,12H2,1H3,(H2,27,28,31)/t17-,20-/m1/s1
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377291
PNG
(US10265310, Example 43 | trans-ent2-1-(4-chlorophe...)
Show SMILES COc1ccc([C@@H]2CC(=O)NC[C@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1S/C19H19ClFN3O3/c1-27-13-6-7-14(16(21)8-13)15-9-18(25)22-10-17(15)24-19(26)23-12-4-2-11(20)3-5-12/h2-8,15,17H,9-10H2,1H3,(H,22,25)(H2,23,24,26)/t15-,17+/m0/s1
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377296
PNG
(US10265310, Example 49 | trans-ent1-1-(4-chlorophe...)
Show SMILES COc1cc(F)c([C@H]2CC(=O)NC[C@@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1S/C19H18ClF2N3O3/c1-28-12-6-14(21)18(15(22)7-12)13-8-17(26)23-9-16(13)25-19(27)24-11-4-2-10(20)3-5-11/h2-7,13,16H,8-9H2,1H3,(H,23,26)(H2,24,25,27)/t13-,16-/m0/s1
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377301
PNG
(US10265310, Example 54 | rrr)
Show SMILES COc1cc(F)c([C@@H]2CC(=O)NC[C@H]2NC(=O)Nc2ccc(Oc3ccccc3)cc2)c(F)c1
Show InChI InChI=1/C25H23F2N3O4/c1-33-18-11-20(26)24(21(27)12-18)19-13-23(31)28-14-22(19)30-25(32)29-15-7-9-17(10-8-15)34-16-5-3-2-4-6-16/h2-12,19,22H,13-14H2,1H3,(H,28,31)(H2,29,30,32)/t19-,22-/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377302
PNG
(US10265310, Example 55 | rrr)
Show SMILES COc1cc(F)c([C@@H]2CC(=O)NC[C@H]2NC(=O)Nc2cc(C)ns2)c(F)c1
Show InChI InChI=1/C17H18F2N4O3S/c1-8-3-15(27-23-8)22-17(25)21-13-7-20-14(24)6-10(13)16-11(18)4-9(26-2)5-12(16)19/h3-5,10,13H,6-7H2,1-2H3,(H,20,24)(H2,21,22,25)/t10-,13-/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377305
PNG
(US10265310, Example 58 | rrr)
Show SMILES COc1cc(F)c([C@@H]2CC(=O)NC[C@H]2NC(=O)Nc2ccc(Cl)c(F)c2)c(F)c1
Show InChI InChI=1/C19H17ClF3N3O3/c1-29-10-5-14(22)18(15(23)6-10)11-7-17(27)24-8-16(11)26-19(28)25-9-2-3-12(20)13(21)4-9/h2-6,11,16H,7-8H2,1H3,(H,24,27)(H2,25,26,28)/t11-,16-/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377308
PNG
(US10265310, Example 61 | US10265310, Example 62 | ...)
Show SMILES COc1ccc(C2CC(=O)N(CC(F)F)CC2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1/C21H21ClF3N3O3/c1-31-14-6-7-15(17(23)8-14)16-9-20(29)28(11-19(24)25)10-18(16)27-21(30)26-13-4-2-12(22)3-5-13/h2-8,16,18-19H,9-11H2,1H3,(H2,26,27,30)
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377312
PNG
(US10265310, Example 65 | US10265310, Example 66 | ...)
Show SMILES FC(F)CN1CC(NC(=O)Nc2ccc(Cl)cc2)C(CC1=O)c1ccc(F)cc1F
Show InChI InChI=1/C20H18ClF4N3O2/c21-11-1-4-13(5-2-11)26-20(30)27-17-9-28(10-18(24)25)19(29)8-15(17)14-6-3-12(22)7-16(14)23/h1-7,15,17-18H,8-10H2,(H2,26,27,30)
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377318
PNG
(US10265310, Example 72 | rac-trans-1-(4-chlorophen...)
Show SMILES CSc1ccc(cc1)[C@H]1CC(=O)NC[C@@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1/C19H20ClN3O2S/c1-26-15-8-2-12(3-9-15)16-10-18(24)21-11-17(16)23-19(25)22-14-6-4-13(20)5-7-14/h2-9,16-17H,10-11H2,1H3,(H,21,24)(H2,22,23,25)/t16-,17+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377320
PNG
(US10265310, Example 74 | rac-trans-1-(4-chlorophen...)
Show SMILES FC(F)Oc1ccc(cc1)[C@H]1CC(=O)NC[C@@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1/C19H18ClF2N3O3/c20-12-3-5-13(6-4-12)24-19(27)25-16-10-23-17(26)9-15(16)11-1-7-14(8-2-11)28-18(21)22/h1-8,15-16,18H,9-10H2,(H,23,26)(H2,24,25,27)/t15-,16+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377323
PNG
(US10265310, Example 77 | trans-ent2-1-(4-chlorophe...)
Show SMILES COc1ccc(cc1)[C@@H]1CC(=O)NC[C@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C19H20ClN3O3/c1-26-15-8-2-12(3-9-15)16-10-18(24)21-11-17(16)23-19(25)22-14-6-4-13(20)5-7-14/h2-9,16-17H,10-11H2,1H3,(H,21,24)(H2,22,23,25)/t16-,17+/m0/s1
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377327
PNG
(US10265310, Example 84 | trans-ent2-1-(4-chlorophe...)
Show SMILES Clc1ccc(NC(=O)N[C@@H]2CN(CC[C@H]2c2ccccc2)C(=O)C2CC2)cc1
Show InChI InChI=1S/C22H24ClN3O2/c23-17-8-10-18(11-9-17)24-22(28)25-20-14-26(21(27)16-6-7-16)13-12-19(20)15-4-2-1-3-5-15/h1-5,8-11,16,19-20H,6-7,12-14H2,(H2,24,25,28)/t19-,20+/m0/s1
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377271
PNG
(US10265310, Example 17 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(Cl)cc1)C(=O)C(C)C
Show InChI InChI=1/C23H28ClN3O3/c1-15(2)22(28)27-13-12-20(16-4-10-19(30-3)11-5-16)21(14-27)26-23(29)25-18-8-6-17(24)7-9-18/h4-11,15,20-21H,12-14H2,1-3H3,(H2,25,26,29)/t20-,21+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377256
PNG
(US10265310, Example 2 | rac-trans-1-(1-acetyl-4-(4...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(Cl)cc1)C(C)=O
Show InChI InChI=1/C21H24ClN3O3/c1-14(26)25-12-11-19(15-3-9-18(28-2)10-4-15)20(13-25)24-21(27)23-17-7-5-16(22)6-8-17/h3-10,19-20H,11-13H2,1-2H3,(H2,23,24,27)/t19-,20+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377258
PNG
(US10265310, Example 4 | rac-trans-1-(4-chloropheny...)
Show SMILES COc1ccc(cc1)[C@H]1CCNC[C@@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1/C19H22ClN3O2/c1-25-16-8-2-13(3-9-16)17-10-11-21-12-18(17)23-19(24)22-15-6-4-14(20)5-7-15/h2-9,17-18,21H,10-12H2,1H3,(H2,22,23,24)/t17-,18+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377259
PNG
(US10265310, Example 5 | rac-trans-1-(1-acetyl-4-(2...)
Show SMILES COc1cc(F)c([C@H]2CCN(C[C@@H]2NC(=O)Nc2ccc(Cl)cc2)C(C)=O)c(F)c1
Show InChI InChI=1/C21H22ClF2N3O3/c1-12(28)27-8-7-16(20-17(23)9-15(30-2)10-18(20)24)19(11-27)26-21(29)25-14-5-3-13(22)4-6-14/h3-6,9-10,16,19H,7-8,11H2,1-2H3,(H2,25,26,29)/t16-,19-/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377266
PNG
(US10265310, Example 12 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(Cl)cc1)C(=O)C1CC1
Show InChI InChI=1/C23H26ClN3O3/c1-30-19-10-4-15(5-11-19)20-12-13-27(22(28)16-2-3-16)14-21(20)26-23(29)25-18-8-6-17(24)7-9-18/h4-11,16,20-21H,2-3,12-14H2,1H3,(H2,25,26,29)/t20-,21+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377277
PNG
(US10265310, Example 24 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1ccc(cc1)[C@H]1CC(=O)N(CC2CC2)C[C@@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1/C23H26ClN3O3/c1-30-19-10-4-16(5-11-19)20-12-22(28)27(13-15-2-3-15)14-21(20)26-23(29)25-18-8-6-17(24)7-9-18/h4-11,15,20-21H,2-3,12-14H2,1H3,(H2,25,26,29)/t20-,21+/s2
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US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377287
PNG
(US10265310, Example 37 | trans-ent2-1-(4-chlorophe...)
Show SMILES COc1cc(F)c([C@@H]2CCNC[C@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1S/C19H20ClF2N3O2/c1-27-13-8-15(21)18(16(22)9-13)14-6-7-23-10-17(14)25-19(26)24-12-4-2-11(20)3-5-12/h2-5,8-9,14,17,23H,6-7,10H2,1H3,(H2,24,25,26)/t14-,17-/m1/s1
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US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377292
PNG
(US10265310, Example 45 | ent1-1-(4-chlorophenyl)-3...)
Show SMILES COc1ccc([C@H]2CCNC[C@@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1/C19H21ClFN3O2/c1-26-14-6-7-15(17(21)10-14)16-8-9-22-11-18(16)24-19(25)23-13-4-2-12(20)3-5-13/h2-7,10,16,18,22H,8-9,11H2,1H3,(H2,23,24,25)/t16-,18+/s2
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US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377298
PNG
(US10265310, Example 51 | rac-trans-1-(5-chlorothio...)
Show SMILES COc1cc(F)c([C@H]2CC(=O)NC[C@@H]2NC(=O)Nc2ccc(Cl)s2)c(F)c1
Show InChI InChI=1/C17H16ClF2N3O3S/c1-26-8-4-10(19)16(11(20)5-8)9-6-14(24)21-7-12(9)22-17(25)23-15-3-2-13(18)27-15/h2-5,9,12H,6-7H2,1H3,(H,21,24)(H2,22,23,25)/t9-,12-/s2
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US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377299
PNG
(US10265310, Example 52 | rrr)
Show SMILES COc1cc(F)c([C@@H]2CC(=O)NC[C@H]2NC(=O)Nc2csc(Cl)c2)c(F)c1
Show InChI InChI=1/C17H16ClF2N3O3S/c1-26-9-3-11(19)16(12(20)4-9)10-5-15(24)21-6-13(10)23-17(25)22-8-2-14(18)27-7-8/h2-4,7,10,13H,5-6H2,1H3,(H,21,24)(H2,22,23,25)/t10-,13-/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377303
PNG
(US10265310, Example 56 | rrr)
Show SMILES COc1cc(F)c([C@@H]2CC(=O)NC[C@H]2NC(=O)Nc2ncc(Cl)s2)c(F)c1
Show InChI InChI=1/C16H15ClF2N4O3S/c1-26-7-2-9(18)14(10(19)3-7)8-4-13(24)20-5-11(8)22-15(25)23-16-21-6-12(17)27-16/h2-3,6,8,11H,4-5H2,1H3,(H,20,24)(H2,21,22,23,25)/t8-,11-/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377304
PNG
(US10265310, Example 57 | rrr)
Show SMILES COc1cc(F)c([C@@H]2CC(=O)NC[C@H]2NC(=O)Nc2ccc(Cl)c(O)c2)c(F)c1
Show InChI InChI=1/C19H18ClF2N3O4/c1-29-10-5-13(21)18(14(22)6-10)11-7-17(27)23-8-15(11)25-19(28)24-9-2-3-12(20)16(26)4-9/h2-6,11,15,26H,7-8H2,1H3,(H,23,27)(H2,24,25,28)/t11-,15-/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377310
PNG
(US10265310, Example 63 | US10265310, Example 64 | ...)
Show SMILES COCCN1CC(NC(=O)Nc2ccc(Cl)cc2)C(CC1=O)c1ccc(F)cc1F
Show InChI InChI=1/C21H22ClF2N3O3/c1-30-9-8-27-12-19(26-21(29)25-15-5-2-13(22)3-6-15)17(11-20(27)28)16-7-4-14(23)10-18(16)24/h2-7,10,17,19H,8-9,11-12H2,1H3,(H2,25,26,29)
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377314
PNG
(US10265310, Example 67 | US10265310, Example 68 | ...)
Show SMILES Fc1ccc(C2CC(=O)NCC2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1/C18H16ClF2N3O2/c19-10-1-4-12(5-2-10)23-18(26)24-16-9-22-17(25)8-14(16)13-6-3-11(20)7-15(13)21/h1-7,14,16H,8-9H2,(H,22,25)(H2,23,24,26)
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377318
PNG
(US10265310, Example 72 | rac-trans-1-(4-chlorophen...)
Show SMILES CSc1ccc(cc1)[C@H]1CC(=O)NC[C@@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1/C19H20ClN3O2S/c1-26-15-8-2-12(3-9-15)16-10-18(24)21-11-17(16)23-19(25)22-14-6-4-13(20)5-7-14/h2-9,16-17H,10-11H2,1H3,(H,21,24)(H2,22,23,25)/t16-,17+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377323
PNG
(US10265310, Example 77 | trans-ent2-1-(4-chlorophe...)
Show SMILES COc1ccc(cc1)[C@@H]1CC(=O)NC[C@H]1NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C19H20ClN3O3/c1-26-15-8-2-12(3-9-15)16-10-18(24)21-11-17(16)23-19(25)22-14-6-4-13(20)5-7-14/h2-9,16-17H,10-11H2,1H3,(H,21,24)(H2,22,23,25)/t16-,17+/m0/s1
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377328
PNG
(US10265310, Example 86 | trans-ent1-1-(4-chlorophe...)
Show SMILES COc1ccc([C@H]2CCN(C[C@@H]2NC(=O)Nc2ccc(Cl)cc2)C(=O)C2CC2)c(F)c1
Show InChI InChI=1S/C23H25ClFN3O3/c1-31-17-8-9-18(20(25)12-17)19-10-11-28(22(29)14-2-3-14)13-21(19)27-23(30)26-16-6-4-15(24)5-7-16/h4-9,12,14,19,21H,2-3,10-11,13H2,1H3,(H2,26,27,30)/t19-,21+/m1/s1
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377329
PNG
(US10265310, Example 88 | rrr)
Show SMILES COc1cc(F)c(C2C(CCCN2C)NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1/C20H22ClF2N3O2/c1-26-9-3-4-17(25-20(27)24-13-7-5-12(21)6-8-13)19(26)18-15(22)10-14(28-2)11-16(18)23/h5-8,10-11,17,19H,3-4,9H2,1-2H3,(H2,24,25,27)
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM377330
PNG
(US10265310, Example 89 | US10265310, Example 90 | ...)
Show SMILES COc1ccc(cc1)C1C(CCCN1C)NC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1/C20H24ClN3O2/c1-24-13-3-4-18(19(24)14-5-11-17(26-2)12-6-14)23-20(25)22-16-9-7-15(21)8-10-16/h5-12,18-19H,3-4,13H2,1-2H3,(H2,22,23,25)
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377270
PNG
(US10265310, Example 16 | rac-trans-1-(4-chlorophen...)
Show SMILES COc1ccc(cc1)[C@H]1CCN(C[C@@H]1NC(=O)Nc1ccc(Cl)cc1)C(=O)C1CCOCC1
Show InChI InChI=1/C25H30ClN3O4/c1-32-21-8-2-17(3-9-21)22-10-13-29(24(30)18-11-14-33-15-12-18)16-23(22)28-25(31)27-20-6-4-19(26)5-7-20/h2-9,18,22-23H,10-16H2,1H3,(H2,27,28,31)/t22-,23+/s2
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Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%