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Patent code US10266513

Compile Data Set for Download or QSAR
Found 190 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377836
PNG
(1-[(3R)-1-acryloyl piperidin-3-yl]-5-amino-3-[4-(4...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(Cl)cc2)cc1)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1/C24H24ClN5O3/c1-2-20(31)29-13-3-4-17(14-29)30-23(26)21(24(27)32)22(28-30)15-5-9-18(10-6-15)33-19-11-7-16(25)8-12-19/h2,5-12,17H,1,3-4,13-14,26H2,(H2,27,32)/t17-/s2
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n/an/a 0.170n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM303543
PNG
(US10138229, Example 54 | US10266513, Example 127)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1/C24H25N5O3/c1-2-20(30)28-14-6-7-17(15-28)29-23(25)21(24(26)31)22(27-29)16-10-12-19(13-11-16)32-18-8-4-3-5-9-18/h2-5,8-13,17H,1,6-7,14-15,25H2,(H2,26,31)/t17-/s2
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n/an/a 0.180n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377842
PNG
(1-[(3S)-1-acryloyl piperidin-3-yl]-5-amino-3-[4-(2...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(F)cc2F)cc1)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1/C24H23F2N5O3/c1-2-20(32)30-11-3-4-16(13-30)31-23(27)21(24(28)33)22(29-31)14-5-8-17(9-6-14)34-19-10-7-15(25)12-18(19)26/h2,5-10,12,16H,1,3-4,11,13,27H2,(H2,28,33)
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n/an/a 0.25n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377707
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-phenoxyphen...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H22N6O2/c23-14-27-12-4-5-16(13-27)28-21(24)19(22(25)29)20(26-28)15-8-10-18(11-9-15)30-17-6-2-1-3-7-17/h1-3,6-11,16H,4-5,12-13,24H2,(H2,25,29)
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n/an/a 0.370n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377839
PNG
(5-amino-3-[4-(4-chlorophenoxy)phenyl]-1-{(3R)-1-[(...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(Cl)cc2)cc1)C1CCCN(C1)C(=O)\C=C\C(F)F
Show InChI InChI=1/C25H24ClF2N5O3/c26-16-5-9-19(10-6-16)36-18-7-3-15(4-8-18)23-22(25(30)35)24(29)33(31-23)17-2-1-13-32(14-17)21(34)12-11-20(27)28/h3-12,17,20H,1-2,13-14,29H2,(H2,30,35)/b12-11+
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n/an/a 0.380n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377831
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(phenylthio...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Sc2ccccc2)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H22N6OS/c23-14-27-12-4-5-16(13-27)28-21(24)19(22(25)29)20(26-28)15-8-10-18(11-9-15)30-17-6-2-1-3-7-17/h1-3,6-11,16H,4-5,12-13,24H2,(H2,25,29)
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n/an/a 0.400n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377722
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(3,4-dimeth...)
Show SMILES Cc1ccc(Oc2ccc(cc2)-c2nn(C3CCCN(C3)C#N)c(N)c2C(N)=O)cc1C
Show InChI InChI=1/C24H26N6O2/c1-15-5-8-20(12-16(15)2)32-19-9-6-17(7-10-19)22-21(24(27)31)23(26)30(28-22)18-4-3-11-29(13-18)14-25/h5-10,12,18H,3-4,11,13,26H2,1-2H3,(H2,27,31)
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n/an/a 0.400n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377850
PNG
(5-amino-1-{(3R)-1-[(2E)-4,4-difluorobut-2-enoyl]pi...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(F)cc2F)cc1)C1CCCN(C1)C(=O)\C=C\C(F)F
Show InChI InChI=1/C25H23F4N5O3/c26-15-5-8-19(18(27)12-15)37-17-6-3-14(4-7-17)23-22(25(31)36)24(30)34(32-23)16-2-1-11-33(13-16)21(35)10-9-20(28)29/h3-10,12,16,20H,1-2,11,13,30H2,(H2,31,36)/b10-9+
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n/an/a 0.410n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377734
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(3-fluoro-4...)
Show SMILES Cc1ccc(Oc2ccc(cc2)-c2nn(C3CCCN(C3)C#N)c(N)c2C(N)=O)cc1F
Show InChI InChI=1/C23H23FN6O2/c1-14-4-7-18(11-19(14)24)32-17-8-5-15(6-9-17)21-20(23(27)31)22(26)30(28-21)16-3-2-10-29(12-16)13-25/h4-9,11,16H,2-3,10,12,26H2,1H3,(H2,27,31)
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n/an/a 0.430n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377754
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)- 3-[4-(3-methoxy...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn(C3CCCN(C3)C#N)c(N)c2C(N)=O)c1
Show InChI InChI=1/C23H24N6O3/c1-31-18-5-2-6-19(12-18)32-17-9-7-15(8-10-17)21-20(23(26)30)22(25)29(27-21)16-4-3-11-28(13-16)14-24/h2,5-10,12,16H,3-4,11,13,25H2,1H3,(H2,26,30)
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n/an/a 0.440n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377827
PNG
(5-amino-1-[(3R*,6S*)-1-cyano-6-methylpiperidin-3-y...)
Show SMILES C[C@H]1CC[C@H](CN1C#N)n1nc(c(C(N)=O)c1N)-c1ccc(Oc2ccc(F)cc2F)cc1
Show InChI InChI=1/C23H22F2N6O2/c1-13-2-6-16(11-30(13)12-26)31-22(27)20(23(28)32)21(29-31)14-3-7-17(8-4-14)33-19-9-5-15(24)10-18(19)25/h3-5,7-10,13,16H,2,6,11,27H2,1H3,(H2,28,32)/t13-,16+/s2
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n/an/a 0.460n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377859
PNG
(1-[(3R)-1-acryloyl piperidin-3-yl]-5-amino-3-{4-[(...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ncc(Cl)cc2F)cc1)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1/C23H22ClFN6O3/c1-2-18(32)30-9-3-4-15(12-30)31-21(26)19(22(27)33)20(29-31)13-5-7-16(8-6-13)34-23-17(25)10-14(24)11-28-23/h2,5-8,10-11,15H,1,3-4,9,12,26H2,(H2,27,33)
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n/an/a 0.480n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377778
PNG
((R)-5-amino-3-(4-(2-chlorobenzyl)phenyl)-1-(1-cyan...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Cc2ccccc2Cl)cc1)[C@@H]1CCCN(C1)C#N
Show InChI InChI=1/C23H23ClN6O/c24-19-6-2-1-4-17(19)12-15-7-9-16(10-8-15)21-20(23(27)31)22(26)30(28-21)18-5-3-11-29(13-18)14-25/h1-2,4,6-10,18H,3,5,11-13,26H2,(H2,27,31)/t18-/s2
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n/an/a 0.540n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377775
PNG
((R)-5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-(3-meth...)
Show SMILES Cc1cccc(Cc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C#N)c(N)c2C(N)=O)c1
Show InChI InChI=1/C24H26N6O/c1-16-4-2-5-18(12-16)13-17-7-9-19(10-8-17)22-21(24(27)31)23(26)30(28-22)20-6-3-11-29(14-20)15-25/h2,4-5,7-10,12,20H,3,6,11,13-14,26H2,1H3,(H2,27,31)/t20-/s2
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377719
PNG
(5-amino-3-[4-(4-chlorophenoxy)phenyl]-1-(1-cyanopi...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(Cl)cc2)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H21ClN6O2/c23-15-5-9-18(10-6-15)31-17-7-3-14(4-8-17)20-19(22(26)30)21(25)29(27-20)16-2-1-11-28(12-16)13-24/h3-10,16H,1-2,11-12,25H2,(H2,26,30)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377861
PNG
(5-amino-3-{4-[(5-chloro-3-fluoropyridin-2-yl)oxy]p...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ncc(Cl)cc2F)cc1)C1CCCN(C1)C(=O)\C=C\C(F)F
Show InChI InChI=1/C24H22ClF3N6O3/c25-14-10-17(26)24(31-11-14)37-16-5-3-13(4-6-16)21-20(23(30)36)22(29)34(32-21)15-2-1-9-33(12-15)19(35)8-7-18(27)28/h3-8,10-11,15,18H,1-2,9,12,29H2,(H2,30,36)/b8-7+
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377830
PNG
(5-amino-3-{4-[(4-chlorophenyl)thio]phenyl}-1-(1-cy...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Sc2ccc(Cl)cc2)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H21ClN6OS/c23-15-5-9-18(10-6-15)31-17-7-3-14(4-8-17)20-19(22(26)30)21(25)29(27-20)16-2-1-11-28(12-16)13-24/h3-10,16H,1-2,11-12,25H2,(H2,26,30)
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n/an/a 0.740n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377749
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(2, 5-diflu...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2cc(F)ccc2F)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H20F2N6O2/c23-14-5-8-17(24)18(10-14)32-16-6-3-13(4-7-16)20-19(22(27)31)21(26)30(28-20)15-2-1-9-29(11-15)12-25/h3-8,10,15H,1-2,9,11,26H2,(H2,27,31)
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n/an/a 0.770n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377741
PNG
(5-amino-3-[4-(2-chloro-4-fluorophenoxy)phenyl]-1-(...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(F)cc2Cl)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H20ClFN6O2/c23-17-10-14(24)5-8-18(17)32-16-6-3-13(4-7-16)20-19(22(27)31)21(26)30(28-20)15-2-1-9-29(11-15)12-25/h3-8,10,15H,1-2,9,11,26H2,(H2,27,31)
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n/an/a 0.790n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377751
PNG
(5-amino-3-[4-(2-chloro-5-fluoro- phenoxy)phenyl]-1...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2cc(F)ccc2Cl)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H20ClFN6O2/c23-17-8-5-14(24)10-18(17)32-16-6-3-13(4-7-16)20-19(22(27)31)21(26)30(28-20)15-2-1-9-29(11-15)12-25/h3-8,10,15H,1-2,9,11,26H2,(H2,27,31)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377781
PNG
((R)-5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-(2-fluo...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Cc2ccccc2F)cc1)[C@@H]1CCCN(C1)C#N
Show InChI InChI=1/C23H23FN6O/c24-19-6-2-1-4-17(19)12-15-7-9-16(10-8-15)21-20(23(27)31)22(26)30(28-21)18-5-3-11-29(13-18)14-25/h1-2,4,6-10,18H,3,5,11-13,26H2,(H2,27,31)/t18-/s2
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377835
PNG
(5-amino-1-{(3R)-1-[(2E)-4-hydroxybut-2-enoyl]piper...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)[C@@H]1CCCN(C1)C(=O)\C=C\CO
Show InChI InChI=1/C25H27N5O4/c26-24-22(25(27)33)23(17-10-12-20(13-11-17)34-19-7-2-1-3-8-19)28-30(24)18-6-4-14-29(16-18)21(32)9-5-15-31/h1-3,5,7-13,18,31H,4,6,14-16,26H2,(H2,27,33)/b9-5+/t18-/s2
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377780
PNG
(5-amino-1-(1-cyanopiperidn-3-yl)-3-[4-(2-fluoroben...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Cc2ccccc2F)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C23H23FN6O/c24-19-6-2-1-4-17(19)12-15-7-9-16(10-8-15)21-20(23(27)31)22(26)30(28-21)18-5-3-11-29(13-18)14-25/h1-2,4,6-10,18H,3,5,11-13,26H2,(H2,27,31)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377734
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(3-fluoro-4...)
Show SMILES Cc1ccc(Oc2ccc(cc2)-c2nn(C3CCCN(C3)C#N)c(N)c2C(N)=O)cc1F
Show InChI InChI=1/C23H23FN6O2/c1-14-4-7-18(11-19(14)24)32-17-8-5-15(6-9-17)21-20(23(27)31)22(26)30(28-21)16-3-2-10-29(12-16)13-25/h4-9,11,16H,2-3,10,12,26H2,1H3,(H2,27,31)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377726
PNG
(5-amino-3-[4-(4-chloro-2-methylphenoxy)phenyl]-1-(...)
Show SMILES Cc1cc(Cl)ccc1Oc1ccc(cc1)-c1nn(C2CCCN(C2)C#N)c(N)c1C(N)=O
Show InChI InChI=1/C23H23ClN6O2/c1-14-11-16(24)6-9-19(14)32-18-7-4-15(5-8-18)21-20(23(27)31)22(26)30(28-21)17-3-2-10-29(12-17)13-25/h4-9,11,17H,2-3,10,12,26H2,1H3,(H2,27,31)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377725
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(4-ethylphe...)
Show SMILES CCc1ccc(Oc2ccc(cc2)-c2nn(C3CCCN(C3)C#N)c(N)c2C(N)=O)cc1
Show InChI InChI=1/C24H26N6O2/c1-2-16-5-9-19(10-6-16)32-20-11-7-17(8-12-20)22-21(24(27)31)23(26)30(28-22)18-4-3-13-29(14-18)15-25/h5-12,18H,2-4,13-14,26H2,1H3,(H2,27,31)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377745
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(2-fluoro-4...)
Show SMILES Cc1ccc(Oc2ccc(cc2)-c2nn(C3CCCN(C3)C#N)c(N)c2C(N)=O)c(F)c1
Show InChI InChI=1/C23H23FN6O2/c1-14-4-9-19(18(24)11-14)32-17-7-5-15(6-8-17)21-20(23(27)31)22(26)30(28-21)16-3-2-10-29(12-16)13-25/h4-9,11,16H,2-3,10,12,26H2,1H3,(H2,27,31)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377838
PNG
(5-amino-3-[4-(4-chlorophenoxy)phenyl]-1-{(3R)-1-[(...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(Cl)cc2)cc1)[C@@H]1CCCN(C1)C(=O)\C=C\CF
Show InChI InChI=1/C25H25ClFN5O3/c26-17-7-11-20(12-8-17)35-19-9-5-16(6-10-19)23-22(25(29)34)24(28)32(30-23)18-3-2-14-31(15-18)21(33)4-1-13-27/h1,4-12,18H,2-3,13-15,28H2,(H2,29,34)/b4-1+/t18-/s2
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377760
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)- 3-[4-(3-fluoro-...)
Show SMILES Cc1c(F)cccc1Oc1ccc(cc1)-c1nn(C2CCCN(C2)C#N)c(N)c1C(N)=O
Show InChI InChI=1/C23H23FN6O2/c1-14-18(24)5-2-6-19(14)32-17-9-7-15(8-10-17)21-20(23(27)31)22(26)30(28-21)16-4-3-11-29(12-16)13-25/h2,5-10,16H,3-4,11-12,26H2,1H3,(H2,27,31)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377748
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(4-methylph...)
Show SMILES Cc1ccc(Oc2ccc(cc2)-c2nn(C3CCCN(C3)C#N)c(N)c2C(N)=O)cc1
Show InChI InChI=1/C23H24N6O2/c1-15-4-8-18(9-5-15)31-19-10-6-16(7-11-19)21-20(23(26)30)22(25)29(27-21)17-3-2-12-28(13-17)14-24/h4-11,17H,2-3,12-13,25H2,1H3,(H2,26,30)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377841
PNG
(5-amino-3-[4-(4-chlorophenoxy)phenyl]-1-{(3R)-1-[(...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(Cl)cc2)cc1)C1CCCN(C1)C(=O)\C=C\C#N
Show InChI InChI=1/C25H23ClN6O3/c26-17-7-11-20(12-8-17)35-19-9-5-16(6-10-19)23-22(25(29)34)24(28)32(30-23)18-3-2-14-31(15-18)21(33)4-1-13-27/h1,4-12,18H,2-3,14-15,28H2,(H2,29,34)/b4-1+
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377867
PNG
(1-[(3R)-1-acryloyl piperidin-3-yl]-5-amino-3-(4-{[...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2cccc(n2)C(F)(F)F)cc1)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1/C24H23F3N6O3/c1-2-19(34)32-12-4-5-15(13-32)33-22(28)20(23(29)35)21(31-33)14-8-10-16(11-9-14)36-18-7-3-6-17(30-18)24(25,26)27/h2-3,6-11,15H,1,4-5,12-13,28H2,(H2,29,35)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377722
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(3,4-dimeth...)
Show SMILES Cc1ccc(Oc2ccc(cc2)-c2nn(C3CCCN(C3)C#N)c(N)c2C(N)=O)cc1C
Show InChI InChI=1/C24H26N6O2/c1-15-5-8-20(12-16(15)2)32-19-9-6-17(7-10-19)22-21(24(27)31)23(26)30(28-22)18-4-3-11-29(13-18)14-25/h5-10,12,18H,3-4,11,13,26H2,1-2H3,(H2,27,31)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377762
PNG
(5-amino-3-[4-(2-chlorophenoxy)- phenyl]-1-(1-cyano...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2Cl)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H21ClN6O2/c23-17-5-1-2-6-18(17)31-16-9-7-14(8-10-16)20-19(22(26)30)21(25)29(27-20)15-4-3-11-28(12-15)13-24/h1-2,5-10,15H,3-4,11-12,25H2,(H2,26,30)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377793
PNG
(5-Amino-3-(4-benzoyl-phenyl)-1-(1-cyano)-piperidin...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(cc1)C(=O)c1ccccc1)C1CCCN(C1)C#N
Show InChI InChI=1/C23H22N6O2/c24-14-28-12-4-7-18(13-28)29-22(25)19(23(26)31)20(27-29)15-8-10-17(11-9-15)21(30)16-5-2-1-3-6-16/h1-3,5-6,8-11,18H,4,7,12-13,25H2,(H2,26,31)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377869
PNG
(5-amino-1-{(3R)-1-[(2E)-4,4-difluorobut-2-enoyl]pi...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2cccc(n2)C(F)(F)F)cc1)C1CCCN(C1)C(=O)\C=C\C(F)F
Show InChI InChI=1/C25H23F5N6O3/c26-18(27)10-11-20(37)35-12-2-3-15(13-35)36-23(31)21(24(32)38)22(34-36)14-6-8-16(9-7-14)39-19-5-1-4-17(33-19)25(28,29)30/h1,4-11,15,18H,2-3,12-13,31H2,(H2,32,38)/b11-10+
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377832
PNG
(1-[(3S)-1-acryloyl piperidin-3-yl]-5-amino-3-(4-ph...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)[C@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1/C24H25N5O3/c1-2-20(30)28-14-6-7-17(15-28)29-23(25)21(24(26)31)22(27-29)16-10-12-19(13-11-16)32-18-8-4-3-5-9-18/h2-5,8-13,17H,1,6-7,14-15,25H2,(H2,26,31)/t17-/s2
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377863
PNG
(1-[(3R)-1-acryloyl piperidin-3-yl]-5-amino-3-{4-[(...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(Cl)cn2)cc1)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1/C23H23ClN6O3/c1-2-19(31)29-11-3-4-16(13-29)30-22(25)20(23(26)32)21(28-30)14-5-8-17(9-6-14)33-18-10-7-15(24)12-27-18/h2,5-10,12,16H,1,3-4,11,13,25H2,(H2,26,32)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377865
PNG
(5-amino-3-{4-[(5-chloropyridin-2-yl)oxy]phenyl}-1-...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(Cl)cn2)cc1)C1CCCN(C1)C(=O)\C=C\C(F)F
Show InChI InChI=1/C24H23ClF2N6O3/c25-15-5-9-19(30-12-15)36-17-6-3-14(4-7-17)22-21(24(29)35)23(28)33(31-22)16-2-1-11-32(13-16)20(34)10-8-18(26)27/h3-10,12,16,18H,1-2,11,13,28H2,(H2,29,35)/b10-8+
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377731
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(2,4-difluo...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(F)cc2F)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H20F2N6O2/c23-14-5-8-18(17(24)10-14)32-16-6-3-13(4-7-16)20-19(22(27)31)21(26)30(28-20)15-2-1-9-29(11-15)12-25/h3-8,10,15H,1-2,9,11,26H2,(H2,27,31)
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n/an/a 1.30n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377783
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(3-fluorobe...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Cc2cccc(F)c2)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C23H23FN6O/c24-18-4-1-3-16(12-18)11-15-6-8-17(9-7-15)21-20(23(27)31)22(26)30(28-21)19-5-2-10-29(13-19)14-25/h1,3-4,6-9,12,19H,2,5,10-11,13,26H2,(H2,27,31)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377862
PNG
(5-amino-3-{4-[(5-chloro-3-fluoropyridin-2-yl)oxy]p...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ncc(Cl)cc2F)cc1)C1CCCN(C1)C(=O)\C=C\CF
Show InChI InChI=1/C24H23ClF2N6O3/c25-15-11-18(27)24(30-12-15)36-17-7-5-14(6-8-17)21-20(23(29)35)22(28)33(31-21)16-3-2-10-32(13-16)19(34)4-1-9-26/h1,4-8,11-12,16H,2-3,9-10,13,28H2,(H2,29,35)/b4-1+
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377707
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-phenoxyphen...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H22N6O2/c23-14-27-12-4-5-16(13-27)28-21(24)19(22(25)29)20(26-28)15-8-10-18(11-9-15)30-17-6-2-1-3-7-17/h1-3,6-11,16H,4-5,12-13,24H2,(H2,25,29)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377746
PNG
(5-amino-3-[4-(4-chloro-3-methylphenoxy)phenyl]-1-(...)
Show SMILES Cc1cc(Oc2ccc(cc2)-c2nn(C3CCCN(C3)C#N)c(N)c2C(N)=O)ccc1Cl
Show InChI InChI=1/C23H23ClN6O2/c1-14-11-18(8-9-19(14)24)32-17-6-4-15(5-7-17)21-20(23(27)31)22(26)30(28-21)16-3-2-10-29(12-16)13-25/h4-9,11,16H,2-3,10,12,26H2,1H3,(H2,27,31)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377858
PNG
(5-amino-1-{(3R)-1-[(2E)-3-cyanoprop-2-enoyl]piperi...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(F)cc2F)cc1)C1CCCN(C1)C(=O)\C=C\C#N
Show InChI InChI=1/C25H22F2N6O3/c26-16-7-10-20(19(27)13-16)36-18-8-5-15(6-9-18)23-22(25(30)35)24(29)33(31-23)17-3-2-12-32(14-17)21(34)4-1-11-28/h1,4-10,13,17H,2-3,12,14,29H2,(H2,30,35)/b4-1+
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377753
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)- 3-{4-[4-fluoro-...)
Show SMILES COc1cc(F)ccc1Oc1ccc(cc1)-c1nn(C2CCCN(C2)C#N)c(N)c1C(N)=O
Show InChI InChI=1/C23H23FN6O3/c1-32-19-11-15(24)6-9-18(19)33-17-7-4-14(5-8-17)21-20(23(27)31)22(26)30(28-21)16-3-2-10-29(12-16)13-25/h4-9,11,16H,2-3,10,12,26H2,1H3,(H2,27,31)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377741
PNG
(5-amino-3-[4-(2-chloro-4-fluorophenoxy)phenyl]-1-(...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(F)cc2Cl)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H20ClFN6O2/c23-17-10-14(24)5-8-18(17)32-16-6-3-13(4-7-16)20-19(22(27)31)21(26)30(28-20)15-2-1-9-29(11-15)12-25/h3-8,10,15H,1-2,9,11,26H2,(H2,27,31)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377759
PNG
(5-amino-3-[4-(3-chlorophenoxy)- phenyl]-1-(1-cyano...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2cccc(Cl)c2)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H21ClN6O2/c23-15-3-1-5-18(11-15)31-17-8-6-14(7-9-17)20-19(22(26)30)21(25)29(27-20)16-4-2-10-28(12-16)13-24/h1,3,5-9,11,16H,2,4,10,12,25H2,(H2,26,30)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377756
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)- 3-[4-(2,4- dich...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(Cl)cc2Cl)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H20Cl2N6O2/c23-14-5-8-18(17(24)10-14)32-16-6-3-13(4-7-16)20-19(22(27)31)21(26)30(28-20)15-2-1-9-29(11-15)12-25/h3-8,10,15H,1-2,9,11,26H2,(H2,27,31)
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n/an/a 1.80n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377764
PNG
(5-amino-3-[4-(3-chloro-4-fluoro- phenoxy)phenyl]-1...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(F)c(Cl)c2)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H20ClFN6O2/c23-17-10-16(7-8-18(17)24)32-15-5-3-13(4-6-15)20-19(22(27)31)21(26)30(28-20)14-2-1-9-29(11-14)12-25/h3-8,10,14H,1-2,9,11,26H2,(H2,27,31)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377757
PNG
(5-amino-3-[4-(3-chloro-5-fluoro- phenoxy)phenyl]-1...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2cc(F)cc(Cl)c2)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H20ClFN6O2/c23-14-8-15(24)10-18(9-14)32-17-5-3-13(4-6-17)20-19(22(27)31)21(26)30(28-20)16-2-1-7-29(11-16)12-25/h3-6,8-10,16H,1-2,7,11,26H2,(H2,27,31)
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n/an/a 1.90n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377774
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(3-methylbe...)
Show SMILES Cc1cccc(Cc2ccc(cc2)-c2nn(C3CCCN(C3)C#N)c(N)c2C(N)=O)c1
Show InChI InChI=1/C24H26N6O/c1-16-4-2-5-18(12-16)13-17-7-9-19(10-8-17)22-21(24(27)31)23(26)30(28-22)20-6-3-11-29(14-20)15-25/h2,4-5,7-10,12,20H,3,6,11,13-14,26H2,1H3,(H2,27,31)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377731
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(2,4-difluo...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(F)cc2F)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H20F2N6O2/c23-14-5-8-18(17(24)10-14)32-16-6-3-13(4-7-16)20-19(22(27)31)21(26)30(28-20)15-2-1-9-29(11-15)12-25/h3-8,10,15H,1-2,9,11,26H2,(H2,27,31)
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n/an/a 2.18n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377761
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)- 3-[4-(2,5-dichl...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2cc(Cl)ccc2Cl)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H20Cl2N6O2/c23-14-5-8-17(24)18(10-14)32-16-6-3-13(4-7-16)20-19(22(27)31)21(26)30(28-20)15-2-1-9-29(11-15)12-25/h3-8,10,15H,1-2,9,11,26H2,(H2,27,31)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377872
PNG
(5-amino-1-{(3R)-1-[(2E)-3-cyanoprop-2-enoyl]piperi...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2cccc(n2)C(F)(F)F)cc1)C1CCCN(C1)C(=O)\C=C\C#N
Show InChI InChI=1/C25H22F3N7O3/c26-25(27,28)18-5-1-6-19(32-18)38-17-10-8-15(9-11-17)22-21(24(31)37)23(30)35(33-22)16-4-3-13-34(14-16)20(36)7-2-12-29/h1-2,5-11,16H,3-4,13-14,30H2,(H2,31,37)/b7-2+
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377755
PNG
(5-amino-3-[4-(5-chloro-2- fluorophenoxy)phenyl]-1-...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2cc(Cl)ccc2F)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H20ClFN6O2/c23-14-5-8-17(24)18(10-14)32-16-6-3-13(4-7-16)20-19(22(27)31)21(26)30(28-20)15-2-1-9-29(11-15)12-25/h3-8,10,15H,1-2,9,11,26H2,(H2,27,31)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377837
PNG
(5-amino-3-[4-(4-chlorophenoxy)phenyl]-1-{(3R)-1-[(...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(Cl)cc2)cc1)[C@@H]1CCCN(C1)C(=O)\C=C\CO
Show InChI InChI=1/C25H26ClN5O4/c26-17-7-11-20(12-8-17)35-19-9-5-16(6-10-19)23-22(25(28)34)24(27)31(29-23)18-3-1-13-30(15-18)21(33)4-2-14-32/h2,4-12,18,32H,1,3,13-15,27H2,(H2,28,34)/b4-2+/t18-/s2
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377783
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(3-fluorobe...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Cc2cccc(F)c2)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C23H23FN6O/c24-18-4-1-3-16(12-18)11-15-6-8-17(9-7-15)21-20(23(27)31)22(26)30(28-21)19-5-2-10-29(13-19)14-25/h1,3-4,6-9,12,19H,2,5,10-11,13,26H2,(H2,27,31)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377857
PNG
(5-am no-3-[4-(2,4-difluorophenoxy)phenyl]-1-{(3R)-...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(F)cc2F)cc1)C1CCCN(C1)C(=O)\C=C\CO
Show InChI InChI=1/C25H25F2N5O4/c26-16-7-10-20(19(27)13-16)36-18-8-5-15(6-9-18)23-22(25(29)35)24(28)32(30-23)17-3-1-11-31(14-17)21(34)4-2-12-33/h2,4-10,13,17,33H,1,3,11-12,14,28H2,(H2,29,35)/b4-2+
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n/an/a 2.30n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377773
PNG
(5-amino-3-(4-benzylphenyl)-1-(1 cyanopiperidin-3-1...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Cc2ccccc2)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C23H24N6O/c24-15-28-12-4-7-19(14-28)29-22(25)20(23(26)30)21(27-29)18-10-8-17(9-11-18)13-16-5-2-1-3-6-16/h1-3,5-6,8-11,19H,4,7,12-14,25H2,(H2,26,30)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377744
PNG
(5-amino-3-[4-(2-chloro-4-methylphenoxy)phenyl]-1-(...)
Show SMILES Cc1ccc(Oc2ccc(cc2)-c2nn(C3CCCN(C3)C#N)c(N)c2C(N)=O)c(Cl)c1
Show InChI InChI=1/C23H23ClN6O2/c1-14-4-9-19(18(24)11-14)32-17-7-5-15(6-8-17)21-20(23(27)31)22(26)30(28-21)16-3-2-10-29(12-16)13-25/h4-9,11,16H,2-3,10,12,26H2,1H3,(H2,27,31)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377822
PNG
((R)-5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-((6-(tr...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2cccc(n2)C(F)(F)F)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H20F3N7O2/c23-22(24,25)16-4-1-5-17(29-16)34-15-8-6-13(7-9-15)19-18(21(28)33)20(27)32(30-19)14-3-2-10-31(11-14)12-26/h1,4-9,14H,2-3,10-11,27H2,(H2,28,33)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377719
PNG
(5-amino-3-[4-(4-chlorophenoxy)phenyl]-1-(1-cyanopi...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(Cl)cc2)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H21ClN6O2/c23-15-5-9-18(10-6-15)31-17-7-3-14(4-8-17)20-19(22(26)30)21(25)29(27-20)16-2-1-11-28(12-16)13-24/h3-10,16H,1-2,11-12,25H2,(H2,26,30)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377777
PNG
(5-amino-3-(4-(2-chlorobenzyl)phenyl)-1-(1-cyanopip...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Cc2ccccc2Cl)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C23H23ClN6O/c24-19-6-2-1-4-17(19)12-15-7-9-16(10-8-15)21-20(23(27)31)22(26)30(28-21)18-5-3-11-29(13-18)14-25/h1-2,4,6-10,18H,3,5,11-13,26H2,(H2,27,31)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377851
PNG
(5-amino-3-[4-(2,4-difluorophenoxy)phenyl]-1-{(3R)-...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(F)cc2F)cc1)C1CCCN(C1)C(=O)\C=C\CF
Show InChI InChI=1/C25H24F3N5O3/c26-11-1-4-21(34)32-12-2-3-17(14-32)33-24(29)22(25(30)35)23(31-33)15-5-8-18(9-6-15)36-20-10-7-16(27)13-19(20)28/h1,4-10,13,17H,2-3,11-12,14,29H2,(H2,30,35)/b4-1+
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377737
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(4-fluoro-3...)
Show SMILES Cc1cc(Oc2ccc(cc2)-c2nn(C3CCCN(C3)C#N)c(N)c2C(N)=O)ccc1F
Show InChI InChI=1/C23H23FN6O2/c1-14-11-18(8-9-19(14)24)32-17-6-4-15(5-7-17)21-20(23(27)31)22(26)30(28-21)16-3-2-10-29(12-16)13-25/h4-9,11,16H,2-3,10,12,26H2,1H3,(H2,27,31)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377734
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(3-fluoro-4...)
Show SMILES Cc1ccc(Oc2ccc(cc2)-c2nn(C3CCCN(C3)C#N)c(N)c2C(N)=O)cc1F
Show InChI InChI=1/C23H23FN6O2/c1-14-4-7-18(11-19(14)24)32-17-8-5-15(6-9-17)21-20(23(27)31)22(26)30(28-21)16-3-2-10-29(12-16)13-25/h4-9,11,16H,2-3,10,12,26H2,1H3,(H2,27,31)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377758
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)- 3-{4-[2-(triflu...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2C(F)(F)F)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C23H21F3N6O2/c24-23(25,26)17-5-1-2-6-18(17)34-16-9-7-14(8-10-16)20-19(22(29)33)21(28)32(30-20)15-4-3-11-31(12-15)13-27/h1-2,5-10,15H,3-4,11-12,28H2,(H2,29,33)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM377859
PNG
(1-[(3R)-1-acryloyl piperidin-3-yl]-5-amino-3-{4-[(...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ncc(Cl)cc2F)cc1)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1/C23H22ClFN6O3/c1-2-18(32)30-9-3-4-15(12-30)31-21(26)19(22(27)33)20(29-31)13-5-7-16(8-6-13)34-23-17(25)10-14(24)11-28-23/h2,5-8,10-11,15H,1,3-4,9,12,26H2,(H2,27,33)
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n/an/a 2.90n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 20 μM ATP, 100 nM peptide substrate ...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377722
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(3,4-dimeth...)
Show SMILES Cc1ccc(Oc2ccc(cc2)-c2nn(C3CCCN(C3)C#N)c(N)c2C(N)=O)cc1C
Show InChI InChI=1/C24H26N6O2/c1-15-5-8-20(12-16(15)2)32-19-9-6-17(7-10-19)22-21(24(27)31)23(26)30(28-22)18-4-3-11-29(13-18)14-25/h5-10,12,18H,3-4,11,13,26H2,1-2H3,(H2,27,31)
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n/an/a 3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377763
PNG
(5-amino-3-[4-(3-chloro-2-fluoro- phenoxy)phenyl]-1...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2cccc(Cl)c2F)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H20ClFN6O2/c23-16-4-1-5-17(19(16)24)32-15-8-6-13(7-9-15)20-18(22(27)31)21(26)30(28-20)14-3-2-10-29(11-14)12-25/h1,4-9,14H,2-3,10-11,26H2,(H2,27,31)
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n/an/a 3.10n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377795
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-(3-phenoxyphen...)
Show SMILES NC(=O)c1c(N)n(nc1-c1cccc(Oc2ccccc2)c1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H22N6O2/c23-14-27-11-5-7-16(13-27)28-21(24)19(22(25)29)20(26-28)15-6-4-10-18(12-15)30-17-8-2-1-3-9-17/h1-4,6,8-10,12,16H,5,7,11,13,24H2,(H2,25,29)
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n/an/a 3.20n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377870
PNG
(5-amino-1-{(3R)-1-[(2E)-4-fluorobut-2-enoyl]piperi...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2cccc(n2)C(F)(F)F)cc1)C1CCCN(C1)C(=O)\C=C\CF
Show InChI InChI=1/C25H24F4N6O3/c26-12-2-7-20(36)34-13-3-4-16(14-34)35-23(30)21(24(31)37)22(33-35)15-8-10-17(11-9-15)38-19-6-1-5-18(32-19)25(27,28)29/h1-2,5-11,16H,3-4,12-14,30H2,(H2,31,37)/b7-2+
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n/an/a 3.20n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377768
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)- 3-{4-[2- (trifl...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2OC(F)(F)F)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C23H21F3N6O3/c24-23(25,26)35-18-6-2-1-5-17(18)34-16-9-7-14(8-10-16)20-19(22(29)33)21(28)32(30-20)15-4-3-11-31(12-15)13-27/h1-2,5-10,15H,3-4,11-12,28H2,(H2,29,33)
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n/an/a 3.30n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377707
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-phenoxyphen...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H22N6O2/c23-14-27-12-4-5-16(13-27)28-21(24)19(22(25)29)20(26-28)15-8-10-18(11-9-15)30-17-6-2-1-3-7-17/h1-3,6-11,16H,4-5,12-13,24H2,(H2,25,29)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377726
PNG
(5-amino-3-[4-(4-chloro-2-methylphenoxy)phenyl]-1-(...)
Show SMILES Cc1cc(Cl)ccc1Oc1ccc(cc1)-c1nn(C2CCCN(C2)C#N)c(N)c1C(N)=O
Show InChI InChI=1/C23H23ClN6O2/c1-14-11-16(24)6-9-19(14)32-18-7-4-15(5-8-18)21-20(23(27)31)22(26)30(28-21)17-3-2-10-29(12-17)13-25/h4-9,11,17H,2-3,10,12,26H2,1H3,(H2,27,31)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377821
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-{4-[(3, 5-difl...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ncc(F)cc2F)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C21H19F2N7O2/c22-13-8-16(23)21(27-9-13)32-15-5-3-12(4-6-15)18-17(20(26)31)19(25)30(28-18)14-2-1-7-29(10-14)11-24/h3-6,8-9,14H,1-2,7,10,25H2,(H2,26,31)
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n/an/a 3.70n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377846
PNG
(5-amino-3-[4-(2,4-difluorophenoxy)phenyl]-1-{(3R)-...)
Show SMILES CN(C)C\C=C\C(=O)N1CCCC(C1)n1nc(c(C(N)=O)c1N)-c1ccc(Oc2ccc(F)cc2F)cc1
Show InChI InChI=1/C27H30F2N6O3/c1-33(2)13-4-6-23(36)34-14-3-5-19(16-34)35-26(30)24(27(31)37)25(32-35)17-7-10-20(11-8-17)38-22-12-9-18(28)15-21(22)29/h4,6-12,15,19H,3,5,13-14,16,30H2,1-2H3,(H2,31,37)/b6-4+
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n/an/a 3.70n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377738
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(4-fluoro-2...)
Show SMILES Cc1cc(F)ccc1Oc1ccc(cc1)-c1nn(C2CCCN(C2)C#N)c(N)c1C(N)=O
Show InChI InChI=1/C23H23FN6O2/c1-14-11-16(24)6-9-19(14)32-18-7-4-15(5-8-18)21-20(23(27)31)22(26)30(28-21)17-3-2-10-29(12-17)13-25/h4-9,11,17H,2-3,10,12,26H2,1H3,(H2,27,31)
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n/an/a 3.80n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377738
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(4-fluoro-2...)
Show SMILES Cc1cc(F)ccc1Oc1ccc(cc1)-c1nn(C2CCCN(C2)C#N)c(N)c1C(N)=O
Show InChI InChI=1/C23H23FN6O2/c1-14-11-16(24)6-9-19(14)32-18-7-4-15(5-8-18)21-20(23(27)31)22(26)30(28-21)17-3-2-10-29(12-17)13-25/h4-9,11,17H,2-3,10,12,26H2,1H3,(H2,27,31)
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n/an/a 4.10n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377871
PNG
(5-amino-1-[(3R)-1-(2-fluoroacryloyl)piperidin-3-yl...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2cccc(n2)C(F)(F)F)cc1)C1CCCN(C1)C(=O)C(F)=C
Show InChI InChI=1/C24H22F4N6O3/c1-13(25)23(36)33-11-3-4-15(12-33)34-21(29)19(22(30)35)20(32-34)14-7-9-16(10-8-14)37-18-6-2-5-17(31-18)24(26,27)28/h2,5-10,15H,1,3-4,11-12,29H2,(H2,30,35)
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n/an/a 4.40n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377834
PNG
(5-amino-1-{1-[(2E)-but-2-enoyl]piperidin-3-yl}-3-(...)
Show SMILES C\C=C\C(=O)N1CCCC(C1)n1nc(c(C(N)=O)c1N)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1/C25H27N5O3/c1-2-7-21(31)29-15-6-8-18(16-29)30-24(26)22(25(27)32)23(28-30)17-11-13-20(14-12-17)33-19-9-4-3-5-10-19/h2-5,7,9-14,18H,6,8,15-16,26H2,1H3,(H2,27,32)/b7-2+
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377766
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)- 3-[4-(3,5-dichl...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2cc(Cl)cc(Cl)c2)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H20Cl2N6O2/c23-14-8-15(24)10-18(9-14)32-17-5-3-13(4-6-17)20-19(22(27)31)21(26)30(28-20)16-2-1-7-29(11-16)12-25/h3-6,8-10,16H,1-2,7,11,26H2,(H2,27,31)
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n/an/a 4.80n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377769
PNG
(5-amino-3-[4-(2-chloro-6-fluoro- phenoxy)phenyl]-1...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2c(F)cccc2Cl)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H20ClFN6O2/c23-16-4-1-5-17(24)20(16)32-15-8-6-13(7-9-15)19-18(22(27)31)21(26)30(28-19)14-3-2-10-29(11-14)12-25/h1,4-9,14H,2-3,10-11,26H2,(H2,27,31)
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n/an/a 4.90n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377730
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(4-isopropy...)
Show SMILES CC(C)c1ccc(Oc2ccc(cc2)-c2nn(C3CCCN(C3)C#N)c(N)c2C(N)=O)cc1
Show InChI InChI=1/C25H28N6O2/c1-16(2)17-5-9-20(10-6-17)33-21-11-7-18(8-12-21)23-22(25(28)32)24(27)31(29-23)19-4-3-13-30(14-19)15-26/h5-12,16,19H,3-4,13-14,27H2,1-2H3,(H2,28,32)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377840
PNG
(5-amino-3-[4-(4-chlorophenoxy)phenyl]-1-[(3R)-1-(2...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(Cl)cc2)cc1)C1CCCN(C1)C(=O)C(F)=C
Show InChI InChI=1/C24H23ClFN5O3/c1-14(26)24(33)30-12-2-3-17(13-30)31-22(27)20(23(28)32)21(29-31)15-4-8-18(9-5-15)34-19-10-6-16(25)7-11-19/h4-11,17H,1-3,12-13,27H2,(H2,28,32)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377767
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)- 3-[4-(2,3,4- tr...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(F)c(F)c2F)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H19F3N6O2/c23-15-7-8-16(19(25)18(15)24)33-14-5-3-12(4-6-14)20-17(22(28)32)21(27)31(29-20)13-2-1-9-30(10-13)11-26/h3-8,13H,1-2,9-10,27H2,(H2,28,32)
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n/an/a 5.10n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377856
PNG
(5-amino-3-[4-(2,4-difluorophenoxy)phenyl]-1-[(3R)-...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(F)cc2F)cc1)C1CCCN(C1)C(=O)C(F)=C
Show InChI InChI=1/C24H22F3N5O3/c1-13(25)24(34)31-10-2-3-16(12-31)32-22(28)20(23(29)33)21(30-32)14-4-7-17(8-5-14)35-19-9-6-15(26)11-18(19)27/h4-9,11,16H,1-3,10,12,28H2,(H2,29,33)
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n/an/a 5.30n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377807
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)- 3-[3-(4-isoprop...)
Show SMILES CC(C)c1ccc(Oc2cccc(c2)-c2nn(C3CCCN(C3)C#N)c(N)c2C(N)=O)cc1C
Show InChI InChI=1/C26H30N6O2/c1-16(2)22-10-9-21(12-17(22)3)34-20-8-4-6-18(13-20)24-23(26(29)33)25(28)32(30-24)19-7-5-11-31(14-19)15-27/h4,6,8-10,12-13,16,19H,5,7,11,14,28H2,1-3H3,(H2,29,33)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377866
PNG
(5-amino-3-{4-[(5-chloropyridin-2-yl)oxy]phenyl}-1-...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(Cl)cn2)cc1)C1CCCN(C1)C(=O)\C=C\CF
Show InChI InChI=1/C24H24ClFN6O3/c25-16-7-10-19(29-13-16)35-18-8-5-15(6-9-18)22-21(24(28)34)23(27)32(30-22)17-3-2-12-31(14-17)20(33)4-1-11-26/h1,4-10,13,17H,2-3,11-12,14,27H2,(H2,28,34)/b4-1+
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377789
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(3,4-difluo...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Cc2ccc(F)c(F)c2)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C23H22F2N6O/c24-18-8-5-15(11-19(18)25)10-14-3-6-16(7-4-14)21-20(23(28)32)22(27)31(29-21)17-2-1-9-30(12-17)13-26/h3-8,11,17H,1-2,9-10,12,27H2,(H2,28,32)
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n/an/a 5.60n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377794
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-{4-[hydroxy(ph...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(cc1)C(O)c1ccccc1)C1CCCN(C1)C#N
Show InChI InChI=1/C23H24N6O2/c24-14-28-12-4-7-18(13-28)29-22(25)19(23(26)31)20(27-29)15-8-10-17(11-9-15)21(30)16-5-2-1-3-6-16/h1-3,5-6,8-11,18,21,30H,4,7,12-13,25H2,(H2,26,31)
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n/an/a 5.70n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377786
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(2,4-difluo...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Cc2ccc(F)cc2F)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C23H22F2N6O/c24-17-8-7-16(19(25)11-17)10-14-3-5-15(6-4-14)21-20(23(28)32)22(27)31(29-21)18-2-1-9-30(12-18)13-26/h3-8,11,18H,1-2,9-10,12,27H2,(H2,28,32)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377717
PNG
(5-amino-1-(2-cyano-2-azabicyclo[2.2.1]hept-5-yl)-3...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)C1CC2CC1CN2C#N
Show InChI InChI=1/C23H22N6O2/c24-13-28-12-15-10-16(28)11-19(15)29-22(25)20(23(26)30)21(27-29)14-6-8-18(9-7-14)31-17-4-2-1-3-5-17/h1-9,15-16,19H,10-12,25H2,(H2,26,30)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377779
PNG
((S)-5-amino-3-(4-(2-chlorobenzyl)phenyl)-1-(1-cyan...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Cc2ccccc2Cl)cc1)[C@H]1CCCN(C1)C#N
Show InChI InChI=1/C23H23ClN6O/c24-19-6-2-1-4-17(19)12-15-7-9-16(10-8-15)21-20(23(27)31)22(26)30(28-21)18-5-3-11-29(13-18)14-25/h1-2,4,6-10,18H,3,5,11-13,26H2,(H2,27,31)/t18-/s2
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377747
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(4-fluoroph...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(F)cc2)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H21FN6O2/c23-15-5-9-18(10-6-15)31-17-7-3-14(4-8-17)20-19(22(26)30)21(25)29(27-20)16-2-1-11-28(12-16)13-24/h3-10,16H,1-2,11-12,25H2,(H2,26,30)
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Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377752
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)- 3-{4-[4-fluoro-...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(F)c(OC(F)(F)F)c2)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C23H20F4N6O3/c24-17-8-7-16(10-18(17)36-23(25,26)27)35-15-5-3-13(4-6-15)20-19(22(30)34)21(29)33(31-20)14-2-1-9-32(11-14)12-28/h3-8,10,14H,1-2,9,11,29H2,(H2,30,34)
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n/an/a 6.40n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377772
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)- 3-[4-(3,5-diflu...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2cc(F)cc(F)c2)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H20F2N6O2/c23-14-8-15(24)10-18(9-14)32-17-5-3-13(4-6-17)20-19(22(27)31)21(26)30(28-20)16-2-1-7-29(11-16)12-25/h3-6,8-10,16H,1-2,7,11,26H2,(H2,27,31)
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n/an/a 7.20n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377824
PNG
((R)-5-amino-3-(4-((5-chloro-3-fluoropyridin-2-yl)o...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ncc(Cl)cc2F)cc1)[C@@H]1CCCN(C1)C#N
Show InChI InChI=1/C21H19ClFN7O2/c22-13-8-16(23)21(27-9-13)32-15-5-3-12(4-6-15)18-17(20(26)31)19(25)30(28-18)14-2-1-7-29(10-14)11-24/h3-6,8-9,14H,1-2,7,10,25H2,(H2,26,31)/t14-/s2
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n/an/a 7.60n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377808
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)- 3-[3-(3,4- dime...)
Show SMILES Cc1cccc(Oc2cccc(c2)-c2nn(C3CCCN(C3)C#N)c(N)c2C(N)=O)c1C
Show InChI InChI=1/C24H26N6O2/c1-15-6-3-10-20(16(15)2)32-19-9-4-7-17(12-19)22-21(24(27)31)23(26)30(28-22)18-8-5-11-29(13-18)14-25/h3-4,6-7,9-10,12,18H,5,8,11,13,26H2,1-2H3,(H2,27,31)
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n/an/a 7.60n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377795
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-(3-phenoxyphen...)
Show SMILES NC(=O)c1c(N)n(nc1-c1cccc(Oc2ccccc2)c1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H22N6O2/c23-14-27-11-5-7-16(13-27)28-21(24)19(22(25)29)20(26-28)15-6-4-10-18(12-15)30-17-8-2-1-3-9-17/h1-4,6,8-10,12,16H,5,7,11,13,24H2,(H2,25,29)
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n/an/a 7.70n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377842
PNG
(1-[(3S)-1-acryloyl piperidin-3-yl]-5-amino-3-[4-(2...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(F)cc2F)cc1)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1/C24H23F2N5O3/c1-2-20(32)30-11-3-4-16(13-30)31-23(27)21(24(28)33)22(29-31)14-5-8-17(9-6-14)34-19-10-7-15(25)12-18(19)26/h2,5-10,12,16H,1,3-4,11,13,27H2,(H2,28,33)
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n/an/a 7.80n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377814
PNG
(5-amino-3-(4-((5-chloropyridin-2-yl)oxy)phenyl)-1-...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(Cl)cn2)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C21H20ClN7O2/c22-14-5-8-17(26-10-14)31-16-6-3-13(4-7-16)19-18(21(25)30)20(24)29(27-19)15-2-1-9-28(11-15)12-23/h3-8,10,15H,1-2,9,11,24H2,(H2,25,30)
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n/an/a 7.80n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM377836
PNG
(1-[(3R)-1-acryloyl piperidin-3-yl]-5-amino-3-[4-(4...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(Cl)cc2)cc1)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1/C24H24ClN5O3/c1-2-20(31)29-13-3-4-17(14-29)30-23(26)21(24(27)32)22(28-30)15-5-9-18(10-6-15)33-19-11-7-16(25)8-12-19/h2,5-12,17H,1,3-4,13-14,26H2,(H2,27,32)/t17-/s2
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n/an/a 7.90n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 20 μM ATP, 100 nM peptide substrate ...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377765
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)- 3-[4-(2,4,5- tr...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2cc(F)c(F)cc2F)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H19F3N6O2/c23-15-8-17(25)18(9-16(15)24)33-14-5-3-12(4-6-14)20-19(22(28)32)21(27)31(29-20)13-2-1-7-30(10-13)11-26/h3-6,8-9,13H,1-2,7,10,27H2,(H2,28,32)
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n/an/a 8.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377770
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)- 3-{4-[4-fluoro-...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(F)c(c2)C(F)(F)F)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C23H20F4N6O2/c24-18-8-7-16(10-17(18)23(25,26)27)35-15-5-3-13(4-6-15)20-19(22(30)34)21(29)33(31-20)14-2-1-9-32(11-14)12-28/h3-8,10,14H,1-2,9,11,29H2,(H2,30,34)
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n/an/a 8.70n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377729
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(2,4-dimeth...)
Show SMILES Cc1ccc(Oc2ccc(cc2)-c2nn(C3CCCN(C3)C#N)c(N)c2C(N)=O)c(C)c1
Show InChI InChI=1/C24H26N6O2/c1-15-5-10-20(16(2)12-15)32-19-8-6-17(7-9-19)22-21(24(27)31)23(26)30(28-22)18-4-3-11-29(13-18)14-25/h5-10,12,18H,3-4,11,13,26H2,1-2H3,(H2,27,31)
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n/an/a 9.20n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377814
PNG
(5-amino-3-(4-((5-chloropyridin-2-yl)oxy)phenyl)-1-...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(Cl)cn2)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C21H20ClN7O2/c22-14-5-8-17(26-10-14)31-16-6-3-13(4-7-16)19-18(21(25)30)20(24)29(27-19)15-2-1-9-28(11-15)12-23/h3-8,10,15H,1-2,9,11,24H2,(H2,25,30)
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n/an/a 9.20n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377868
PNG
(5-amino-1-{(3R)-1-[(2E)-4-hydroxybut-2-enoyl]piper...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2cccc(n2)C(F)(F)F)cc1)C1CCCN(C1)C(=O)\C=C\CO
Show InChI InChI=1/C25H25F3N6O4/c26-25(27,28)18-5-1-6-19(31-18)38-17-10-8-15(9-11-17)22-21(24(30)37)23(29)34(32-22)16-4-2-12-33(14-16)20(36)7-3-13-35/h1,3,5-11,16,35H,2,4,12-14,29H2,(H2,30,37)/b7-3+
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n/an/a 9.80n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377827
PNG
(5-amino-1-[(3R*,6S*)-1-cyano-6-methylpiperidin-3-y...)
Show SMILES C[C@H]1CC[C@H](CN1C#N)n1nc(c(C(N)=O)c1N)-c1ccc(Oc2ccc(F)cc2F)cc1
Show InChI InChI=1/C23H22F2N6O2/c1-13-2-6-16(11-30(13)12-26)31-22(27)20(23(28)32)21(29-31)14-3-7-17(8-4-14)33-19-9-5-15(24)10-18(19)25/h3-5,7-10,13,16H,2,6,11,27H2,1H3,(H2,28,32)/t13-,16+/s2
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n/an/a 9.90n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377818
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-((5-methylp...)
Show SMILES Cc1ccc(Oc2ccc(cc2)-c2nn(C3CCCN(C3)C#N)c(N)c2C(N)=O)nc1
Show InChI InChI=1/C22H23N7O2/c1-14-4-9-18(26-11-14)31-17-7-5-15(6-8-17)20-19(22(25)30)21(24)29(27-20)16-3-2-10-28(12-16)13-23/h4-9,11,16H,2-3,10,12,24H2,1H3,(H2,25,30)
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n/an/a 10.1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377771
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)- 3-[4-(2-methoxy...)
Show SMILES COc1ccccc1Oc1ccc(cc1)-c1nn(C2CCCN(C2)C#N)c(N)c1C(N)=O
Show InChI InChI=1/C23H24N6O3/c1-31-18-6-2-3-7-19(18)32-17-10-8-15(9-11-17)21-20(23(26)30)22(25)29(27-21)16-5-4-12-28(13-16)14-24/h2-3,6-11,16H,4-5,12-13,25H2,1H3,(H2,26,30)
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n/an/a 10.6n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377712
PNG
(5-amino-1-[1-(cyanomethyl)piperidin-3-yl]-3-(4-phe...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(CC#N)CC1
Show InChI InChI=1S/C23H24N6O2/c24-12-15-28-13-10-17(11-14-28)29-22(25)20(23(26)30)21(27-29)16-6-8-19(9-7-16)31-18-4-2-1-3-5-18/h1-9,17H,10-11,13-15,25H2,(H2,26,30)
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n/an/a 11.7n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377780
PNG
(5-amino-1-(1-cyanopiperidn-3-yl)-3-[4-(2-fluoroben...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Cc2ccccc2F)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C23H23FN6O/c24-19-6-2-1-4-17(19)12-15-7-9-16(10-8-15)21-20(23(27)31)22(26)30(28-21)18-5-3-11-29(13-18)14-25/h1-2,4,6-10,18H,3,5,11-13,26H2,(H2,27,31)
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n/an/a 12n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377719
PNG
(5-amino-3-[4-(4-chlorophenoxy)phenyl]-1-(1-cyanopi...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(Cl)cc2)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H21ClN6O2/c23-15-5-9-18(10-6-15)31-17-7-3-14(4-8-17)20-19(22(26)30)21(25)29(27-20)16-2-1-11-28(12-16)13-24/h3-10,16H,1-2,11-12,25H2,(H2,26,30)
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n/an/a 12.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377809
PNG
(5-amino-3-[3-(3-chloro-4- methylphenoxy)-phenyl]-1...)
Show SMILES Cc1cccc(Oc2cccc(c2)-c2nn(C3CCCN(C3)C#N)c(N)c2C(N)=O)c1Cl
Show InChI InChI=1/C23H23ClN6O2/c1-14-5-2-9-18(20(14)24)32-17-8-3-6-15(11-17)21-19(23(27)31)22(26)30(28-21)16-7-4-10-29(12-16)13-25/h2-3,5-6,8-9,11,16H,4,7,10,12,26H2,1H3,(H2,27,31)
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n/an/a 13.4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377716
PNG
(5-amino-1-(4-cyano-1,4-oxazepan-6-yl)-3-(4-phenoxy...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)C1COCCN(C1)C#N
Show InChI InChI=1/C22H22N6O3/c23-14-27-10-11-30-13-16(12-27)28-21(24)19(22(25)29)20(26-28)15-6-8-18(9-7-15)31-17-4-2-1-3-5-17/h1-9,16H,10-13,24H2,(H2,25,29)
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n/an/a 13.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377789
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(3,4-difluo...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Cc2ccc(F)c(F)c2)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C23H22F2N6O/c24-18-8-5-15(11-19(18)25)10-14-3-6-16(7-4-14)21-20(23(28)32)22(27)31(29-21)17-2-1-9-30(12-17)13-26/h3-8,11,17H,1-2,9-10,12,27H2,(H2,28,32)
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n/an/a 15.3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377786
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(2,4-difluo...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Cc2ccc(F)cc2F)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C23H22F2N6O/c24-17-8-7-16(19(25)11-17)10-14-3-5-15(6-4-14)21-20(23(28)32)22(27)31(29-21)18-2-1-9-30(12-18)13-26/h3-8,11,18H,1-2,9-10,12,27H2,(H2,28,32)
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n/an/a 15.6n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377805
PNG
(5-amino-3-[3-(4-chloro-3- methylphenoxy)-phenyl]-1...)
Show SMILES Cc1cc(Oc2cccc(c2)-c2nn(C3CCCN(C3)C#N)c(N)c2C(N)=O)ccc1Cl
Show InChI InChI=1/C23H23ClN6O2/c1-14-10-18(7-8-19(14)24)32-17-6-2-4-15(11-17)21-20(23(27)31)22(26)30(28-21)16-5-3-9-29(12-16)13-25/h2,4,6-8,10-11,16H,3,5,9,12,26H2,1H3,(H2,27,31)
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n/an/a 15.6n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377713
PNG
(5-amino-1-(1-cyanopyrrolidin-3-yl)-3-(4-phenoxyphe...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(C1)C#N
Show InChI InChI=1/C21H20N6O2/c22-13-26-11-10-15(12-26)27-20(23)18(21(24)28)19(25-27)14-6-8-17(9-7-14)29-16-4-2-1-3-5-16/h1-9,15H,10-12,23H2,(H2,24,28)
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n/an/a 16.2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377806
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)- 3-[3-(4-isoprop...)
Show SMILES CC(C)c1ccc(Oc2cccc(c2)-c2nn(C3CCCN(C3)C#N)c(N)c2C(N)=O)cc1
Show InChI InChI=1/C25H28N6O2/c1-16(2)17-8-10-20(11-9-17)33-21-7-3-5-18(13-21)23-22(25(28)32)24(27)31(29-23)19-6-4-12-30(14-19)15-26/h3,5,7-11,13,16,19H,4,6,12,14,27H2,1-2H3,(H2,28,32)
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n/an/a 16.3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377818
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-((5-methylp...)
Show SMILES Cc1ccc(Oc2ccc(cc2)-c2nn(C3CCCN(C3)C#N)c(N)c2C(N)=O)nc1
Show InChI InChI=1/C22H23N7O2/c1-14-4-9-18(26-11-14)31-17-7-5-15(6-8-17)20-19(22(25)30)21(24)29(27-20)16-3-2-10-28(12-16)13-23/h4-9,11,16H,2-3,10,12,24H2,1H3,(H2,25,30)
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n/an/a 16.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377714
PNG
(5-amino-1-[1-(cyanomethyl)pyrrolidin-3-yl]-3-(4-ph...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(CC#N)C1
Show InChI InChI=1/C22H22N6O2/c23-11-13-27-12-10-16(14-27)28-21(24)19(22(25)29)20(26-28)15-6-8-18(9-7-15)30-17-4-2-1-3-5-17/h1-9,16H,10,12-14,24H2,(H2,25,29)
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n/an/a 16.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377731
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(2,4-difluo...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(F)cc2F)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H20F2N6O2/c23-14-5-8-18(17(24)10-14)32-16-6-3-13(4-7-16)20-19(22(27)31)21(26)30(28-20)15-2-1-9-29(11-15)12-25/h3-8,10,15H,1-2,9,11,26H2,(H2,27,31)
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n/an/a 17.3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377822
PNG
((R)-5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-((6-(tr...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2cccc(n2)C(F)(F)F)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H20F3N7O2/c23-22(24,25)16-4-1-5-17(29-16)34-15-8-6-13(7-9-15)19-18(21(28)33)20(27)32(30-19)14-3-2-10-31(11-14)12-26/h1,4-9,14H,2-3,10-11,27H2,(H2,28,33)
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n/an/a 18.9n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377844
PNG
(5-amino-3-[4-(2,4-difluorophenoxy)phenyl]-1-{(3R)-...)
Show SMILES COC\C=C\C(=O)N1CCCC(C1)n1nc(c(C(N)=O)c1N)-c1ccc(Oc2ccc(F)cc2F)cc1
Show InChI InChI=1/C26H27F2N5O4/c1-36-13-3-5-22(34)32-12-2-4-18(15-32)33-25(29)23(26(30)35)24(31-33)16-6-9-19(10-7-16)37-21-11-8-17(27)14-20(21)28/h3,5-11,14,18H,2,4,12-13,15,29H2,1H3,(H2,30,35)/b5-3+
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n/an/a 21.8n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377802
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)- 3-[3-(3-fluoro-...)
Show SMILES Cc1ccc(Oc2cccc(c2)-c2nn(C3CCCN(C3)C#N)c(N)c2C(N)=O)cc1F
Show InChI InChI=1/C23H23FN6O2/c1-14-7-8-18(11-19(14)24)32-17-6-2-4-15(10-17)21-20(23(27)31)22(26)30(28-21)16-5-3-9-29(12-16)13-25/h2,4,6-8,10-11,16H,3,5,9,12,26H2,1H3,(H2,27,31)
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n/an/a 21.9n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377776
PNG
((S)-5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-(3-meth...)
Show SMILES Cc1cccc(Cc2ccc(cc2)-c2nn([C@H]3CCCN(C3)C#N)c(N)c2C(N)=O)c1
Show InChI InChI=1/C24H26N6O/c1-16-4-2-5-18(12-16)13-17-7-9-19(10-8-17)22-21(24(27)31)23(26)30(28-22)20-6-3-11-29(14-20)15-25/h2,4-5,7-10,12,20H,3,6,11,13-14,26H2,1H3,(H2,27,31)/t20-/s2
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n/an/a 21.9n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377726
PNG
(5-amino-3-[4-(4-chloro-2-methylphenoxy)phenyl]-1-(...)
Show SMILES Cc1cc(Cl)ccc1Oc1ccc(cc1)-c1nn(C2CCCN(C2)C#N)c(N)c1C(N)=O
Show InChI InChI=1/C23H23ClN6O2/c1-14-11-16(24)6-9-19(14)32-18-7-4-15(5-8-18)21-20(23(27)31)22(26)30(28-21)17-3-2-10-29(12-17)13-25/h4-9,11,17H,2-3,10,12,26H2,1H3,(H2,27,31)
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n/an/a 22.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377715
PNG
(5-amino-1-(1-cyanoazetidin-3-yl)-3-(4-phenoxypheny...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)C1CN(C1)C#N
Show InChI InChI=1S/C20H18N6O2/c21-12-25-10-14(11-25)26-19(22)17(20(23)27)18(24-26)13-6-8-16(9-7-13)28-15-4-2-1-3-5-15/h1-9,14H,10-11,22H2,(H2,23,27)
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n/an/a 23.3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377738
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(4-fluoro-2...)
Show SMILES Cc1cc(F)ccc1Oc1ccc(cc1)-c1nn(C2CCCN(C2)C#N)c(N)c1C(N)=O
Show InChI InChI=1/C23H23FN6O2/c1-14-11-16(24)6-9-19(14)32-18-7-4-15(5-8-18)21-20(23(27)31)22(26)30(28-21)17-3-2-10-29(12-17)13-25/h4-9,11,17H,2-3,10,12,26H2,1H3,(H2,27,31)
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n/an/a 24.1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377750
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)- 3-[4-(4- isopro...)
Show SMILES CC(C)Oc1ccc(Oc2ccc(cc2)-c2nn(C3CCCN(C3)C#N)c(N)c2C(N)=O)cc1
Show InChI InChI=1/C25H28N6O3/c1-16(2)33-19-9-11-21(12-10-19)34-20-7-5-17(6-8-20)23-22(25(28)32)24(27)31(29-23)18-4-3-13-30(14-18)15-26/h5-12,16,18H,3-4,13-14,27H2,1-2H3,(H2,28,32)
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n/an/a 24.4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377741
PNG
(5-amino-3-[4-(2-chloro-4-fluorophenoxy)phenyl]-1-(...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(F)cc2Cl)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H20ClFN6O2/c23-17-10-14(24)5-8-18(17)32-16-6-3-13(4-7-16)20-19(22(27)31)21(26)30(28-20)15-2-1-9-29(11-15)12-25/h3-8,10,15H,1-2,9,11,26H2,(H2,27,31)
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n/an/a 25.3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM377842
PNG
(1-[(3S)-1-acryloyl piperidin-3-yl]-5-amino-3-[4-(2...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(F)cc2F)cc1)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1/C24H23F2N5O3/c1-2-20(32)30-11-3-4-16(13-30)31-23(27)21(24(28)33)22(29-31)14-5-8-17(9-6-14)34-19-10-7-15(25)12-18(19)26/h2,5-10,12,16H,1,3-4,11,13,27H2,(H2,28,33)
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n/an/a 25.6n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 20 μM ATP, 100 nM peptide substrate ...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377792
PNG
(5-amino-3-[4-(4-chlorobenzyl)phenyl]-(1-cyanopiper...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Cc2ccc(Cl)cc2)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C23H23ClN6O/c24-18-9-5-16(6-10-18)12-15-3-7-17(8-4-15)21-20(23(27)31)22(26)30(28-21)19-2-1-11-29(13-19)14-25/h3-10,19H,1-2,11-13,26H2,(H2,27,31)
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n/an/a 26.8n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377804
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)- 3-[3-(4-methylp...)
Show SMILES Cc1ccc(Oc2cccc(c2)-c2nn(C3CCCN(C3)C#N)c(N)c2C(N)=O)cc1
Show InChI InChI=1/C23H24N6O2/c1-15-7-9-18(10-8-15)31-19-6-2-4-16(12-19)21-20(23(26)30)22(25)29(27-21)17-5-3-11-28(13-17)14-24/h2,4,6-10,12,17H,3,5,11,13,25H2,1H3,(H2,26,30)
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n/an/a 27.3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM377863
PNG
(1-[(3R)-1-acryloyl piperidin-3-yl]-5-amino-3-{4-[(...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(Cl)cn2)cc1)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1/C23H23ClN6O3/c1-2-19(31)29-11-3-4-16(13-29)30-22(25)20(23(26)32)21(28-30)14-5-8-17(9-6-14)33-18-10-7-15(24)12-27-18/h2,5-10,12,16H,1,3-4,11,13,25H2,(H2,26,32)
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n/an/a 29.7n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 20 μM ATP, 100 nM peptide substrate ...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377783
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(3-fluorobe...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Cc2cccc(F)c2)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C23H23FN6O/c24-18-4-1-3-16(12-18)11-15-6-8-17(9-7-15)21-20(23(27)31)22(26)30(28-21)19-5-2-10-29(13-19)14-25/h1,3-4,6-9,12,19H,2,5,10-11,13,26H2,(H2,27,31)
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n/an/a 31n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377711
PNG
(5-amino-1-(1-cyanopiperidin-4-yl)-3-(4-phenoxyphen...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(CC1)C#N
Show InChI InChI=1S/C22H22N6O2/c23-14-27-12-10-16(11-13-27)28-21(24)19(22(25)29)20(26-28)15-6-8-18(9-7-15)30-17-4-2-1-3-5-17/h1-9,16H,10-13,24H2,(H2,25,29)
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n/an/a 32.1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377710
PNG
(5-amino-1-[1-(cyanomethyl)piperidin-3-yl]-3-(4-phe...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)C1CCCN(CC#N)C1
Show InChI InChI=1/C23H24N6O2/c24-12-14-28-13-4-5-17(15-28)29-22(25)20(23(26)30)21(27-29)16-8-10-19(11-9-16)31-18-6-2-1-3-7-18/h1-3,6-11,17H,4-5,13-15,25H2,(H2,26,30)
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n/an/a 35n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377799
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[3-(4-fluorobe...)
Show SMILES NC(=O)c1c(N)n(nc1-c1cccc(Cc2cccc(F)c2)c1)C1CCCN(C1)C#N
Show InChI InChI=1/C23H23FN6O/c24-18-7-2-5-16(12-18)10-15-4-1-6-17(11-15)21-20(23(27)31)22(26)30(28-21)19-8-3-9-29(13-19)14-25/h1-2,4-7,11-12,19H,3,8-10,13,26H2,(H2,27,31)
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n/an/a 35n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377854
PNG
(5-amino-3-[4-(2,4-difluorophenoxy)phenyl]-1-{(3R)-...)
Show SMILES C[C@H](O)\C=C\C(=O)N1CCCC(C1)n1nc(c(C(N)=O)c1N)-c1ccc(Oc2ccc(F)cc2F)cc1
Show InChI InChI=1/C26H27F2N5O4/c1-15(34)4-11-22(35)32-12-2-3-18(14-32)33-25(29)23(26(30)36)24(31-33)16-5-8-19(9-6-16)37-21-10-7-17(27)13-20(21)28/h4-11,13,15,18,34H,2-3,12,14,29H2,1H3,(H2,30,36)/b11-4+/t15-,18?/s2
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n/an/a 39n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377852
PNG
(5-amino-3-[4-(2,4-difluorophenoxy)phenyl]-1-{(3R)-...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(F)cc2F)cc1)C1CCCN(C1)C(=O)C(\F)=C\CO
Show InChI InChI=1/C25H24F3N5O4/c26-15-5-8-20(19(28)12-15)37-17-6-3-14(4-7-17)22-21(24(30)35)23(29)33(31-22)16-2-1-10-32(13-16)25(36)18(27)9-11-34/h3-9,12,16,34H,1-2,10-11,13,29H2,(H2,30,35)/b18-9-
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n/an/a 48n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377860
PNG
(5-amino-3-{4-[(5-chloro-3-fluoropyridin-2-yl)oxy]p...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ncc(Cl)cc2F)cc1)C1CCCN(C1)C(=O)\C=C\CO
Show InChI InChI=1/C24H24ClFN6O4/c25-15-11-18(26)24(29-12-15)36-17-7-5-14(6-8-17)21-20(23(28)35)22(27)32(30-21)16-3-1-9-31(13-16)19(34)4-2-10-33/h2,4-8,11-12,16,33H,1,3,9-10,13,27H2,(H2,28,35)/b4-2+
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n/an/a 49n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377800
PNG
(5-Amino-1-(1-cyanopiperidin-3-yl)-3-(3-(4-fluoroph...)
Show SMILES NC(=O)c1c(N)n(nc1-c1cccc(Oc2ccc(F)cc2)c1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H21FN6O2/c23-15-6-8-17(9-7-15)31-18-5-1-3-14(11-18)20-19(22(26)30)21(25)29(27-20)16-4-2-10-28(12-16)13-24/h1,3,5-9,11,16H,2,4,10,12,25H2,(H2,26,30)
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n/an/a 50.2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377855
PNG
(5-amino-3-(4-(2,4-difluorophenoxy)phenyl)-1-((R)-1...)
Show SMILES C[C@@H](O)\C=C\C(=O)N1CCCC(C1)n1nc(c(C(N)=O)c1N)-c1ccc(Oc2ccc(F)cc2F)cc1
Show InChI InChI=1/C26H27F2N5O4/c1-15(34)4-11-22(35)32-12-2-3-18(14-32)33-25(29)23(26(30)36)24(31-33)16-5-8-19(9-6-16)37-21-10-7-17(27)13-20(21)28/h4-11,13,15,18,34H,2-3,12,14,29H2,1H3,(H2,30,36)/b11-4+/t15-,18?/s2
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n/an/a 52n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377803
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)- 3-[3-(2-isoprop...)
Show SMILES CC(C)c1ccccc1Oc1cccc(c1)-c1nn(C2CCCN(C2)C#N)c(N)c1C(N)=O
Show InChI InChI=1/C25H28N6O2/c1-16(2)20-10-3-4-11-21(20)33-19-9-5-7-17(13-19)23-22(25(28)32)24(27)31(29-23)18-8-6-12-30(14-18)15-26/h3-5,7,9-11,13,16,18H,6,8,12,14,27H2,1-2H3,(H2,28,32)
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n/an/a 52.8n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377810
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)- 3-[3-(3-isoprop...)
Show SMILES CC(C)c1cc(C)ccc1Oc1cccc(c1)-c1nn(C2CCCN(C2)C#N)c(N)c1C(N)=O
Show InChI InChI=1/C26H30N6O2/c1-16(2)21-12-17(3)9-10-22(21)34-20-8-4-6-18(13-20)24-23(26(29)33)25(28)32(30-24)19-7-5-11-31(14-19)15-27/h4,6,8-10,12-13,16,19H,5,7,11,14,28H2,1-3H3,(H2,29,33)
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n/an/a 53.1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377718
PNG
(5-amino-1-[2-(cyanomethyl)-2-azabicyclo[2.2.1]hept...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)C1CC2CC1CN2CC#N
Show InChI InChI=1/C24H24N6O2/c25-10-11-29-14-16-12-17(29)13-20(16)30-23(26)21(24(27)31)22(28-30)15-6-8-19(9-7-15)32-18-4-2-1-3-5-18/h1-9,16-17,20H,11-14,26H2,(H2,27,31)
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n/an/a 54.2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377811
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)- 3-[3-(3,4-diflu...)
Show SMILES NC(=O)c1c(N)n(nc1-c1cccc(Oc2ccc(F)c(F)c2)c1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H20F2N6O2/c23-17-7-6-16(10-18(17)24)32-15-5-1-3-13(9-15)20-19(22(27)31)21(26)30(28-20)14-4-2-8-29(11-14)12-25/h1,3,5-7,9-10,14H,2,4,8,11,26H2,(H2,27,31)
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n/an/a 55.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377812
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)- 3-{3-[3-fluoro-...)
Show SMILES NC(=O)c1c(N)n(nc1-c1cccc(Oc2ccc(OC(F)(F)F)c(F)c2)c1)C1CCCN(C1)C#N
Show InChI InChI=1/C23H20F4N6O3/c24-17-10-16(6-7-18(17)36-23(25,26)27)35-15-5-1-3-13(9-15)20-19(22(30)34)21(29)33(31-20)14-4-2-8-32(11-14)12-28/h1,3,5-7,9-10,14H,2,4,8,11,29H2,(H2,30,34)
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n/an/a 58n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377847
PNG
(5-amino-3-[4-(2,4-difluorophenoxy)phenyl]-1-{(3R)-...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(F)cc2F)cc1)C1CCCN(C1)C(=O)\C=C\CCO
Show InChI InChI=1/C26H27F2N5O4/c27-17-8-11-21(20(28)14-17)37-19-9-6-16(7-10-19)24-23(26(30)36)25(29)33(31-24)18-4-3-12-32(15-18)22(35)5-1-2-13-34/h1,5-11,14,18,34H,2-4,12-13,15,29H2,(H2,30,36)/b5-1+
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n/an/a 58n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377825
PNG
((S)-5-amino-3-(4-((5-chloro-3-fluoropyridin-2-yl)o...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ncc(Cl)cc2F)cc1)[C@H]1CCCN(C1)C#N
Show InChI InChI=1/C21H19ClFN7O2/c22-13-8-16(23)21(27-9-13)32-15-5-3-12(4-6-15)18-17(20(26)31)19(25)30(28-18)14-2-1-7-29(10-14)11-24/h3-6,8-9,14H,1-2,7,10,25H2,(H2,26,31)/t14-/s2
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n/an/a 60.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377848
PNG
(5-amino-1-{(3R)-1-[(2E)-but-2-enoyl]piperidin-3-yl...)
Show SMILES C\C=C\C(=O)N1CCCC(C1)n1nc(c(C(N)=O)c1N)-c1ccc(Oc2ccc(F)cc2F)cc1
Show InChI InChI=1/C25H25F2N5O3/c1-2-4-21(33)31-12-3-5-17(14-31)32-24(28)22(25(29)34)23(30-32)15-6-9-18(10-7-15)35-20-11-8-16(26)13-19(20)27/h2,4,6-11,13,17H,3,5,12,14,28H2,1H3,(H2,29,34)/b4-2+
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n/an/a 61n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377864
PNG
(5-amino-3-{4-[(5-chloropyridin-2-yl)oxy]phenyl}-1-...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(Cl)cn2)cc1)C1CCCN(C1)C(=O)\C=C\CO
Show InChI InChI=1/C24H25ClN6O4/c25-16-7-10-19(28-13-16)35-18-8-5-15(6-9-18)22-21(24(27)34)23(26)31(29-22)17-3-1-11-30(14-17)20(33)4-2-12-32/h2,4-10,13,17,32H,1,3,11-12,14,26H2,(H2,27,34)/b4-2+
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n/an/a 71n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377798
PNG
(5-amino-3-[3-(4-chlorobenzyl)phenyl]-1-(1-cyanopip...)
Show SMILES NC(=O)c1c(N)n(nc1-c1cccc(Cc2cccc(Cl)c2)c1)C1CCCN(C1)C#N
Show InChI InChI=1/C23H23ClN6O/c24-18-7-2-5-16(12-18)10-15-4-1-6-17(11-15)21-20(23(27)31)22(26)30(28-21)19-8-3-9-29(13-19)14-25/h1-2,4-7,11-12,19H,3,8-10,13,26H2,(H2,27,31)
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n/an/a 73.4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377801
PNG
(5-Amino-1-(1-cyanopiperidin-3-yl)- 3-{3-[4- (trifl...)
Show SMILES NC(=O)c1c(N)n(nc1-c1cccc(Oc2ccc(OC(F)(F)F)cc2)c1)C1CCCN(C1)C#N
Show InChI InChI=1/C23H21F3N6O3/c24-23(25,26)35-17-8-6-16(7-9-17)34-18-5-1-3-14(11-18)20-19(22(29)33)21(28)32(30-20)15-4-2-10-31(12-15)13-27/h1,3,5-9,11,15H,2,4,10,12,28H2,(H2,29,33)
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n/an/a 79.2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM377867
PNG
(1-[(3R)-1-acryloyl piperidin-3-yl]-5-amino-3-(4-{[...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2cccc(n2)C(F)(F)F)cc1)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1/C24H23F3N6O3/c1-2-19(34)32-12-4-5-15(13-32)33-22(28)20(23(29)35)21(31-33)14-8-10-16(11-9-14)36-18-7-3-6-17(30-18)24(25,26)27/h2-3,6-11,15H,1,4-5,12-13,28H2,(H2,29,35)
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n/an/a 89.8n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 20 μM ATP, 100 nM peptide substrate ...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM377861
PNG
(5-amino-3-{4-[(5-chloro-3-fluoropyridin-2-yl)oxy]p...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ncc(Cl)cc2F)cc1)C1CCCN(C1)C(=O)\C=C\C(F)F
Show InChI InChI=1/C24H22ClF3N6O3/c25-14-10-17(26)24(31-11-14)37-16-5-3-13(4-6-16)21-20(23(30)36)22(29)34(32-21)15-2-1-9-33(12-15)19(35)8-7-18(27)28/h3-8,10-11,15,18H,1-2,9,12,29H2,(H2,30,36)/b8-7+
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n/an/a 106n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 20 μM ATP, 100 nM peptide substrate ...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377817
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-{4-[(5-fluorop...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(F)cn2)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C21H20FN7O2/c22-14-5-8-17(26-10-14)31-16-6-3-13(4-7-16)19-18(21(25)30)20(24)29(27-19)15-2-1-9-28(11-15)12-23/h3-8,10,15H,1-2,9,11,24H2,(H2,25,30)
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n/an/a 119n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377849
PNG
(5-amino-3-[4-(2,4-difluorophenoxy)phenyl]-1-{(3R)-...)
Show SMILES CC\C=C\C(=O)N1CCCC(C1)n1nc(c(C(N)=O)c1N)-c1ccc(Oc2ccc(F)cc2F)cc1
Show InChI InChI=1/C26H27F2N5O3/c1-2-3-6-22(34)32-13-4-5-18(15-32)33-25(29)23(26(30)35)24(31-33)16-7-10-19(11-8-16)36-21-12-9-17(27)14-20(21)28/h3,6-12,14,18H,2,4-5,13,15,29H2,1H3,(H2,30,35)/b6-3+
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n/an/a 125n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377786
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(2,4-difluo...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Cc2ccc(F)cc2F)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C23H22F2N6O/c24-17-8-7-16(19(25)11-17)10-14-3-5-15(6-4-14)21-20(23(28)32)22(27)31(29-21)18-2-1-9-30(12-18)13-26/h3-8,11,18H,1-2,9-10,12,27H2,(H2,28,32)
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n/an/a 126n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377814
PNG
(5-amino-3-(4-((5-chloropyridin-2-yl)oxy)phenyl)-1-...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(Cl)cn2)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C21H20ClN7O2/c22-14-5-8-17(26-10-14)31-16-6-3-13(4-7-16)19-18(21(25)30)20(24)29(27-19)15-2-1-9-28(11-15)12-23/h3-8,10,15H,1-2,9,11,24H2,(H2,25,30)
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n/an/a 128n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377826
PNG
(5-amino-3-[2-chloro-4-(4-fluorophenoxy)phenyl]-1-(...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(F)cc2)cc1Cl)C1CCCN(C1)C#N
Show InChI InChI=1/C22H20ClFN6O2/c23-18-10-16(32-15-5-3-13(24)4-6-15)7-8-17(18)20-19(22(27)31)21(26)30(28-20)14-2-1-9-29(11-14)12-25/h3-8,10,14H,1-2,9,11,26H2,(H2,27,31)
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n/an/a 141n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377795
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-(3-phenoxyphen...)
Show SMILES NC(=O)c1c(N)n(nc1-c1cccc(Oc2ccccc2)c1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H22N6O2/c23-14-27-11-5-7-16(13-27)28-21(24)19(22(25)29)20(26-28)15-6-4-10-18(12-15)30-17-8-2-1-3-9-17/h1-4,6,8-10,12,16H,5,7,11,13,24H2,(H2,25,29)
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n/an/a 154n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377813
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-(6-phenoxypyri...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)nc1)C1CCCN(C1)C#N
Show InChI InChI=1/C21H21N7O2/c22-13-27-10-4-5-15(12-27)28-20(23)18(21(24)29)19(26-28)14-8-9-17(25-11-14)30-16-6-2-1-3-7-16/h1-3,6-9,11,15H,4-5,10,12,23H2,(H2,24,29)
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n/an/a 171n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377789
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(3,4-difluo...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Cc2ccc(F)c(F)c2)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C23H22F2N6O/c24-18-8-5-15(11-19(18)25)10-14-3-6-16(7-4-14)21-20(23(28)32)22(27)31(29-21)17-2-1-9-30(12-17)13-26/h3-8,11,17H,1-2,9-10,12,27H2,(H2,28,32)
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n/an/a 212n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM377842
PNG
(1-[(3S)-1-acryloyl piperidin-3-yl]-5-amino-3-[4-(2...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(F)cc2F)cc1)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1/C24H23F2N5O3/c1-2-20(32)30-11-3-4-16(13-30)31-23(27)21(24(28)33)22(29-31)14-5-8-17(9-6-14)34-19-10-7-15(25)12-18(19)26/h2,5-10,12,16H,1,3-4,11,13,27H2,(H2,28,33)
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n/an/a 214n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 20 μM ATP, 100 nM peptide substrate ...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377853
PNG
(5-amino-3-[4-(2,4-difluorophenoxy)phenyl]-1-{(3R)-...)
Show SMILES CC(C)(O)\C=C\C(=O)N1CCCC(C1)n1nc(c(C(N)=O)c1N)-c1ccc(Oc2ccc(F)cc2F)cc1
Show InChI InChI=1/C27H29F2N5O4/c1-27(2,37)12-11-22(35)33-13-3-4-18(15-33)34-25(30)23(26(31)36)24(32-34)16-5-8-19(9-6-16)38-21-10-7-17(28)14-20(21)29/h5-12,14,18,37H,3-4,13,15,30H2,1-2H3,(H2,31,36)/b12-11+
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n/an/a 241n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377845
PNG
(5-amino-3-[4-(2,4-difluorophenoxy)phenyl]-1-[(3R)-...)
Show SMILES CC(=C)C(=O)N1CCCC(C1)n1nc(c(C(N)=O)c1N)-c1ccc(Oc2ccc(F)cc2F)cc1
Show InChI InChI=1/C25H25F2N5O3/c1-14(2)25(34)31-11-3-4-17(13-31)32-23(28)21(24(29)33)22(30-32)15-5-8-18(9-6-15)35-20-10-7-16(26)12-19(20)27/h5-10,12,17H,1,3-4,11,13,28H2,2H3,(H2,29,33)
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n/an/a 247n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377818
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-((5-methylp...)
Show SMILES Cc1ccc(Oc2ccc(cc2)-c2nn(C3CCCN(C3)C#N)c(N)c2C(N)=O)nc1
Show InChI InChI=1/C22H23N7O2/c1-14-4-9-18(26-11-14)31-17-7-5-15(6-8-17)20-19(22(25)30)21(24)29(27-20)16-3-2-10-28(12-16)13-23/h4-9,11,16H,2-3,10,12,24H2,1H3,(H2,25,30)
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n/an/a 264n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM377850
PNG
(5-amino-1-{(3R)-1-[(2E)-4,4-difluorobut-2-enoyl]pi...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(F)cc2F)cc1)C1CCCN(C1)C(=O)\C=C\C(F)F
Show InChI InChI=1/C25H23F4N5O3/c26-15-5-8-19(18(27)12-15)37-17-6-3-14(4-7-17)23-22(25(31)36)24(30)34(32-23)16-2-1-11-33(13-16)21(35)10-9-20(28)29/h3-10,12,16,20H,1-2,11,13,30H2,(H2,31,36)/b10-9+
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n/an/a 274n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 20 μM ATP, 100 nM peptide substrate ...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM377865
PNG
(5-amino-3-{4-[(5-chloropyridin-2-yl)oxy]phenyl}-1-...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(Cl)cn2)cc1)C1CCCN(C1)C(=O)\C=C\C(F)F
Show InChI InChI=1/C24H23ClF2N6O3/c25-15-5-9-19(30-12-15)36-17-6-3-14(4-7-17)22-21(24(29)35)23(28)33(31-22)16-2-1-11-32(13-16)20(34)10-8-18(26)27/h3-10,12,16,18H,1-2,11,13,28H2,(H2,29,35)/b10-8+
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n/an/a 311n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 20 μM ATP, 100 nM peptide substrate ...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM377862
PNG
(5-amino-3-{4-[(5-chloro-3-fluoropyridin-2-yl)oxy]p...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ncc(Cl)cc2F)cc1)C1CCCN(C1)C(=O)\C=C\CF
Show InChI InChI=1/C24H23ClF2N6O3/c25-15-11-18(27)24(30-12-15)36-17-7-5-14(6-8-17)21-20(23(29)35)22(28)33(31-21)16-3-2-10-32(13-16)19(34)4-1-9-26/h1,4-8,11-12,16H,2-3,9-10,13,28H2,(H2,29,35)/b4-1+
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n/an/a 381n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 20 μM ATP, 100 nM peptide substrate ...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377829
PNG
(5-amino-1-[(3S,6R)-1-cyano-6-methylpiperidin-3-yl]...)
Show SMILES C[C@@H]1CC[C@@H](CN1C#N)n1nc(c(C(N)=O)c1N)-c1ccc(Oc2ccc(F)cc2F)cc1
Show InChI InChI=1/C23H22F2N6O2/c1-13-2-6-16(11-30(13)12-26)31-22(27)20(23(28)32)21(29-31)14-3-7-17(8-4-14)33-19-9-5-15(24)10-18(19)25/h3-5,7-10,13,16H,2,6,11,27H2,1H3,(H2,28,32)/t13-,16+/s2
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n/an/a 396n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM377832
PNG
(1-[(3S)-1-acryloyl piperidin-3-yl]-5-amino-3-(4-ph...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)[C@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1/C24H25N5O3/c1-2-20(30)28-14-6-7-17(15-28)29-23(25)21(24(26)31)22(27-29)16-10-12-19(13-11-16)32-18-8-4-3-5-9-18/h2-5,8-13,17H,1,6-7,14-15,25H2,(H2,26,31)/t17-/s2
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n/an/a 802n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 20 μM ATP, 100 nM peptide substrate ...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM377866
PNG
(5-amino-3-{4-[(5-chloropyridin-2-yl)oxy]phenyl}-1-...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(Cl)cn2)cc1)C1CCCN(C1)C(=O)\C=C\CF
Show InChI InChI=1/C24H24ClFN6O3/c25-16-7-10-19(29-13-16)35-18-8-5-15(6-9-18)22-21(24(28)34)23(27)32(30-22)17-3-2-12-31(14-17)20(33)4-1-11-26/h1,4-10,13,17H,2-3,11-12,14,27H2,(H2,28,34)/b4-1+
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n/an/a 890n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 20 μM ATP, 100 nM peptide substrate ...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM377869
PNG
(5-amino-1-{(3R)-1-[(2E)-4,4-difluorobut-2-enoyl]pi...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2cccc(n2)C(F)(F)F)cc1)C1CCCN(C1)C(=O)\C=C\C(F)F
Show InChI InChI=1/C25H23F5N6O3/c26-18(27)10-11-20(37)35-12-2-3-15(13-35)36-23(31)21(24(32)38)22(34-36)14-6-8-16(9-7-14)39-19-5-1-4-17(33-19)25(28,29)30/h1,4-11,15,18H,2-3,12-13,31H2,(H2,32,38)/b11-10+
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n/an/a 1.19E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 20 μM ATP, 100 nM peptide substrate ...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM377707
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-phenoxyphen...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H22N6O2/c23-14-27-12-4-5-16(13-27)28-21(24)19(22(25)29)20(26-28)15-8-10-18(11-9-15)30-17-6-2-1-3-7-17/h1-3,6-11,16H,4-5,12-13,24H2,(H2,25,29)
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n/an/a 1.71E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 20 μM ATP, 100 nM peptide substrate ...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM377851
PNG
(5-amino-3-[4-(2,4-difluorophenoxy)phenyl]-1-{(3R)-...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(F)cc2F)cc1)C1CCCN(C1)C(=O)\C=C\CF
Show InChI InChI=1/C25H24F3N5O3/c26-11-1-4-21(34)32-12-2-3-17(14-32)33-24(29)22(25(30)35)23(31-33)15-5-8-18(9-6-15)36-20-10-7-16(27)13-19(20)28/h1,4-10,13,17H,2-3,11-12,14,29H2,(H2,30,35)/b4-1+
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n/an/a 2.18E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 20 μM ATP, 100 nM peptide substrate ...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM377837
PNG
(5-amino-3-[4-(4-chlorophenoxy)phenyl]-1-{(3R)-1-[(...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(Cl)cc2)cc1)[C@@H]1CCCN(C1)C(=O)\C=C\CO
Show InChI InChI=1/C25H26ClN5O4/c26-17-7-11-20(12-8-17)35-19-9-5-16(6-10-19)23-22(25(28)34)24(27)31(29-23)18-3-1-13-30(15-18)21(33)4-2-14-32/h2,4-12,18,32H,1,3,13-15,27H2,(H2,28,34)/b4-2+/t18-/s2
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n/an/a 2.20E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 20 μM ATP, 100 nM peptide substrate ...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM377870
PNG
(5-amino-1-{(3R)-1-[(2E)-4-fluorobut-2-enoyl]piperi...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2cccc(n2)C(F)(F)F)cc1)C1CCCN(C1)C(=O)\C=C\CF
Show InChI InChI=1/C25H24F4N6O3/c26-12-2-7-20(36)34-13-3-4-16(14-34)35-23(30)21(24(31)37)22(33-35)15-8-10-17(11-9-15)38-19-6-1-5-18(32-19)25(27,28)29/h1-2,5-11,16H,3-4,12-14,30H2,(H2,31,37)/b7-2+
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n/an/a 3.36E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 20 μM ATP, 100 nM peptide substrate ...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM377719
PNG
(5-amino-3-[4-(4-chlorophenoxy)phenyl]-1-(1-cyanopi...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(Cl)cc2)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H21ClN6O2/c23-15-5-9-18(10-6-15)31-17-7-3-14(4-8-17)20-19(22(26)30)21(25)29(27-20)16-2-1-11-28(12-16)13-24/h3-10,16H,1-2,11-12,25H2,(H2,26,30)
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n/an/a 3.89E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 20 μM ATP, 100 nM peptide substrate ...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM377857
PNG
(5-am no-3-[4-(2,4-difluorophenoxy)phenyl]-1-{(3R)-...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(F)cc2F)cc1)C1CCCN(C1)C(=O)\C=C\CO
Show InChI InChI=1/C25H25F2N5O4/c26-16-7-10-20(19(27)13-16)36-18-8-5-15(6-9-18)23-22(25(29)35)24(28)32(30-23)17-3-1-11-31(14-17)21(34)4-2-12-33/h2,4-10,13,17,33H,1,3,11-12,14,28H2,(H2,29,35)/b4-2+
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n/an/a 1.21E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 20 μM ATP, 100 nM peptide substrate ...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM377868
PNG
(5-amino-1-{(3R)-1-[(2E)-4-hydroxybut-2-enoyl]piper...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2cccc(n2)C(F)(F)F)cc1)C1CCCN(C1)C(=O)\C=C\CO
Show InChI InChI=1/C25H25F3N6O4/c26-25(27,28)18-5-1-6-19(31-18)38-17-10-8-15(9-11-17)22-21(24(30)37)23(29)34(32-22)16-4-2-12-33(14-16)20(36)7-3-13-35/h1,3,5-11,16,35H,2,4,12-14,29H2,(H2,30,37)/b7-3+
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n/an/a 1.41E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 20 μM ATP, 100 nM peptide substrate ...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM377814
PNG
(5-amino-3-(4-((5-chloropyridin-2-yl)oxy)phenyl)-1-...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(Cl)cn2)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C21H20ClN7O2/c22-14-5-8-17(26-10-14)31-16-6-3-13(4-7-16)19-18(21(25)30)20(24)29(27-19)15-2-1-9-28(11-15)12-23/h3-8,10,15H,1-2,9,11,24H2,(H2,25,30)
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n/an/a>1.54E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 20 μM ATP, 100 nM peptide substrate ...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM377731
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(2,4-difluo...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(F)cc2F)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H20F2N6O2/c23-14-5-8-18(17(24)10-14)32-16-6-3-13(4-7-16)20-19(22(27)31)21(26)30(28-20)15-2-1-9-29(11-15)12-25/h3-8,10,15H,1-2,9,11,26H2,(H2,27,31)
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n/an/a 1.68E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 20 μM ATP, 100 nM peptide substrate ...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM377822
PNG
((R)-5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-((6-(tr...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2cccc(n2)C(F)(F)F)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H20F3N7O2/c23-22(24,25)16-4-1-5-17(29-16)34-15-8-6-13(7-9-15)19-18(21(28)33)20(27)32(30-19)14-3-2-10-31(11-14)12-26/h1,4-9,14H,2-3,10-11,27H2,(H2,28,33)
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n/an/a>2.68E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 20 μM ATP, 100 nM peptide substrate ...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM377824
PNG
((R)-5-amino-3-(4-((5-chloro-3-fluoropyridin-2-yl)o...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ncc(Cl)cc2F)cc1)[C@@H]1CCCN(C1)C#N
Show InChI InChI=1/C21H19ClFN7O2/c22-13-8-16(23)21(27-9-13)32-15-5-3-12(4-6-15)18-17(20(26)31)19(25)30(28-18)14-2-1-7-29(10-14)11-24/h3-6,8-9,14H,1-2,7,10,25H2,(H2,26,31)/t14-/s2
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n/an/a>5.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 20 μM ATP, 100 nM peptide substrate ...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%