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Patent code US10266528

Compile Data Set for Download or QSAR
Found 23 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM378839
PNG
(US10266528, Compound 23)
Show SMILES Cc1cc(ccc1CNC(=O)c1nc(no1)C(C)(C)C)-c1ccnc2[nH]c(=O)[nH]c12
Show InChI InChI=1S/C21H22N6O3/c1-11-9-12(14-7-8-22-16-15(14)24-20(29)25-16)5-6-13(11)10-23-17(28)18-26-19(27-30-18)21(2,3)4/h5-9H,10H2,1-4H3,(H,23,28)(H2,22,24,25,29)
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n/an/a<10n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
Briefly, 2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC...


US Patent US10266528 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM378843
PNG
(US10266528, Compound 18)
Show SMILES CC1(CC1)c1noc(n1)C(=O)NCc1ccc(cc1C(F)(F)F)-c1ccnc2[nH]c(=O)[nH]c12
Show InChI InChI=1S/C21H17F3N6O3/c1-20(5-6-20)18-29-17(33-30-18)16(31)26-9-11-3-2-10(8-13(11)21(22,23)24)12-4-7-25-15-14(12)27-19(32)28-15/h2-4,7-8H,5-6,9H2,1H3,(H,26,31)(H2,25,27,28,32)
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Merck Patent GmbH

US Patent


Assay Description
Briefly, 2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC...


US Patent US10266528 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM378835
PNG
(US10266528, Compound 19)
Show SMILES CC(C)(C)c1nc(no1)C(=O)NCc1ccc(cc1C(F)(F)F)-c1ccnc2[nH]c(=O)[nH]c12
Show InChI InChI=1S/C21H19F3N6O3/c1-20(2,3)18-28-16(30-33-18)17(31)26-9-11-5-4-10(8-13(11)21(22,23)24)12-6-7-25-15-14(12)27-19(32)29-15/h4-8H,9H2,1-3H3,(H,26,31)(H2,25,27,29,32)
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Merck Patent GmbH

US Patent


Assay Description
Briefly, 2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC...


US Patent US10266528 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM378840
PNG
(US10266528, Compound 17)
Show SMILES CC(C)(C)c1noc(n1)C(=O)NCc1ccc(cc1C1CC1)-c1ccnc2[nH]c(=O)[nH]c12
Show InChI InChI=1S/C23H24N6O3/c1-23(2,3)21-28-20(32-29-21)19(30)25-11-14-7-6-13(10-16(14)12-4-5-12)15-8-9-24-18-17(15)26-22(31)27-18/h6-10,12H,4-5,11H2,1-3H3,(H,25,30)(H2,24,26,27,31)
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Merck Patent GmbH

US Patent


Assay Description
Briefly, 2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC...


US Patent US10266528 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM378834
PNG
(US10266528, Compound 12 | US10266528, Compound 13)
Show SMILES CC(C)(C)c1noc(n1)C(=O)NC1CCCCc2cc(ccc12)-c1ccnc2[nH]c(=O)[nH]c12
Show InChI InChI=1/C24H26N6O3/c1-24(2,3)22-29-21(33-30-22)20(31)26-17-7-5-4-6-13-12-14(8-9-15(13)17)16-10-11-25-19-18(16)27-23(32)28-19/h8-12,17H,4-7H2,1-3H3,(H,26,31)(H2,25,27,28,32)
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Merck Patent GmbH

US Patent


Assay Description
Briefly, 2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC...


US Patent US10266528 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM378842
PNG
(US10266528, Compound 2)
Show SMILES CC(C)(C)c1noc(n1)C(=O)NCc1ccc(cc1F)-c1ccnc2[nH]c(=O)[nH]c12
Show InChI InChI=1S/C20H19FN6O3/c1-20(2,3)18-26-17(30-27-18)16(28)23-9-11-5-4-10(8-13(11)21)12-6-7-22-15-14(12)24-19(29)25-15/h4-8H,9H2,1-3H3,(H,23,28)(H2,22,24,25,29)
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Merck Patent GmbH

US Patent


Assay Description
Briefly, 2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC...


US Patent US10266528 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM378841
PNG
(US10266528, Compound 16)
Show SMILES Cc1cc(c(F)cc1CNC(=O)c1nc(no1)C(C)(C)C)-c1ccnc2[nH]c(=O)[nH]c12
Show InChI InChI=1S/C21H21FN6O3/c1-10-7-13(12-5-6-23-16-15(12)25-20(30)26-16)14(22)8-11(10)9-24-17(29)18-27-19(28-31-18)21(2,3)4/h5-8H,9H2,1-4H3,(H,24,29)(H2,23,25,26,30)
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Merck Patent GmbH

US Patent


Assay Description
Briefly, 2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC...


US Patent US10266528 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM378836
PNG
(US10266528, Compound 11)
Show SMILES CC(C)(C)c1noc(n1)C(=O)NC1CCCCc2cc(ccc12)-c1ccnc2[nH]c(=O)[nH]c12
Show InChI InChI=1/C24H26N6O3/c1-24(2,3)22-29-21(33-30-22)20(31)26-17-7-5-4-6-13-12-14(8-9-15(13)17)16-10-11-25-19-18(16)27-23(32)28-19/h8-12,17H,4-7H2,1-3H3,(H,26,31)(H2,25,27,28,32)
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Merck Patent GmbH

US Patent


Assay Description
Briefly, 2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC...


US Patent US10266528 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM378844
PNG
(US10266528, Compound 21)
Show SMILES CC1(C)Cc2cc3C(=O)N(CCn3c2C1)c1cc(F)cc(c1CO)-c1ccnc2[nH]c(=O)[nH]c12
Show InChI InChI=1S/C25H24FN5O3/c1-25(2)10-13-7-19-23(33)31(6-5-30(19)20(13)11-25)18-9-14(26)8-16(17(18)12-32)15-3-4-27-22-21(15)28-24(34)29-22/h3-4,7-9,32H,5-6,10-12H2,1-2H3,(H2,27,28,29,34)
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Merck Patent GmbH

US Patent


Assay Description
Briefly, 2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC...


US Patent US10266528 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM378838
PNG
(US10266528, Compound 1)
Show SMILES CC(C)(C)c1noc(n1)C(=O)NCc1ccc(cc1C(F)(F)F)-c1ccnc2[nH]c(=O)[nH]c12
Show InChI InChI=1S/C21H19F3N6O3/c1-20(2,3)18-29-17(33-30-18)16(31)26-9-11-5-4-10(8-13(11)21(22,23)24)12-6-7-25-15-14(12)27-19(32)28-15/h4-8H,9H2,1-3H3,(H,26,31)(H2,25,27,28,32)
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Merck Patent GmbH

US Patent


Assay Description
Briefly, 2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC...


US Patent US10266528 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM378837
PNG
(US10266528, Compound 14)
Show SMILES CC(C)(C)c1cc(on1)C(=O)NC1CCCCc2cc(ccc12)-c1ccnc2[nH]c(=O)[nH]c12
Show InChI InChI=1/C25H27N5O3/c1-25(2,3)20-13-19(33-30-20)23(31)27-18-7-5-4-6-14-12-15(8-9-16(14)18)17-10-11-26-22-21(17)28-24(32)29-22/h8-13,18H,4-7H2,1-3H3,(H,27,31)(H2,26,28,29,32)
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Merck Patent GmbH

US Patent


Assay Description
Briefly, 2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC...


US Patent US10266528 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM378846
PNG
(US10266528, Compound 3)
Show SMILES CC(C)(C)c1nc(no1)C(=O)NCc1ccc(cc1F)-c1ccnc2[nH]c(=O)[nH]c12
Show InChI InChI=1S/C20H19FN6O3/c1-20(2,3)18-25-16(27-30-18)17(28)23-9-11-5-4-10(8-13(11)21)12-6-7-22-15-14(12)24-19(29)26-15/h4-8H,9H2,1-3H3,(H,23,28)(H2,22,24,26,29)
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Merck Patent GmbH

US Patent


Assay Description
Briefly, 2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC...


US Patent US10266528 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM378847
PNG
(US10266528, Compound 4)
Show SMILES Fc1cc(ccc1CNC(=O)NCC1CC2CCC1C2)-c1ccnc2[nH]c(=O)[nH]c12
Show InChI InChI=1/C22H24FN5O2/c23-18-9-14(17-5-6-24-20-19(17)27-22(30)28-20)3-4-15(18)10-25-21(29)26-11-16-8-12-1-2-13(16)7-12/h3-6,9,12-13,16H,1-2,7-8,10-11H2,(H2,25,26,29)(H2,24,27,28,30)
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Merck Patent GmbH

US Patent


Assay Description
Briefly, 2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC...


US Patent US10266528 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM378851
PNG
(US10266528, Compound 6)
Show SMILES CC(C)(C)c1nc(cs1)C(=O)NCc1ccc(cc1F)-c1ccnc2[nH]c(=O)[nH]c12
Show InChI InChI=1S/C21H20FN5O2S/c1-21(2,3)19-25-15(10-30-19)18(28)24-9-12-5-4-11(8-14(12)22)13-6-7-23-17-16(13)26-20(29)27-17/h4-8,10H,9H2,1-3H3,(H,24,28)(H2,23,26,27,29)
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Merck Patent GmbH

US Patent


Assay Description
Briefly, 2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC...


US Patent US10266528 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM378845
PNG
(US10266528, Compound 15)
Show SMILES CC(C)(C)c1noc(n1)C(=O)NC1CCCc2cc(ccc12)-c1ccnc2[nH]c(=O)[nH]c12
Show InChI InChI=1/C23H24N6O3/c1-23(2,3)21-28-20(32-29-21)19(30)25-16-6-4-5-12-11-13(7-8-14(12)16)15-9-10-24-18-17(15)26-22(31)27-18/h7-11,16H,4-6H2,1-3H3,(H,25,30)(H2,24,26,27,31)
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Merck Patent GmbH

US Patent


Assay Description
Briefly, 2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC...


US Patent US10266528 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM378834
PNG
(US10266528, Compound 12 | US10266528, Compound 13)
Show SMILES CC(C)(C)c1noc(n1)C(=O)NC1CCCCc2cc(ccc12)-c1ccnc2[nH]c(=O)[nH]c12
Show InChI InChI=1/C24H26N6O3/c1-24(2,3)22-29-21(33-30-22)20(31)26-17-7-5-4-6-13-12-14(8-9-15(13)17)16-10-11-25-19-18(16)27-23(32)28-19/h8-12,17H,4-7H2,1-3H3,(H,26,31)(H2,25,27,28,32)
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Merck Patent GmbH

US Patent


Assay Description
Briefly, 2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC...


US Patent US10266528 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM378849
PNG
(US10266528, Compound 22)
Show SMILES CC1(C)Cc2cc3C(=O)N(CCn3c2C1)c1cc(F)cc(c1)-c1ccnc2[nH]c(=O)[nH]c12
Show InChI InChI=1S/C24H22FN5O2/c1-24(2)11-14-9-18-22(31)29(5-6-30(18)19(14)12-24)16-8-13(7-15(25)10-16)17-3-4-26-21-20(17)27-23(32)28-21/h3-4,7-10H,5-6,11-12H2,1-2H3,(H2,26,27,28,32)
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Merck Patent GmbH

US Patent


Assay Description
Briefly, 2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC...


US Patent US10266528 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM378848
PNG
(US10266528, Compound 5)
Show SMILES CC(C)(C)C1CCN(C1)C(=O)NCc1ccc(cc1F)-c1ccnc2[nH]c(=O)[nH]c12
Show InChI InChI=1/C22H26FN5O2/c1-22(2,3)15-7-9-28(12-15)21(30)25-11-14-5-4-13(10-17(14)23)16-6-8-24-19-18(16)26-20(29)27-19/h4-6,8,10,15H,7,9,11-12H2,1-3H3,(H,25,30)(H2,24,26,27,29)
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n/an/a 55n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
Briefly, 2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC...


US Patent US10266528 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM378852
PNG
(US10266528, Compound 20)
Show SMILES CC(C)(C)OC1CN(C1)C(=O)NCc1ccc(cc1C(F)(F)F)-c1ccnc2[nH]c(=O)[nH]c12
Show InChI InChI=1S/C22H24F3N5O3/c1-21(2,3)33-14-10-30(11-14)20(32)27-9-13-5-4-12(8-16(13)22(23,24)25)15-6-7-26-18-17(15)28-19(31)29-18/h4-8,14H,9-11H2,1-3H3,(H,27,32)(H2,26,28,29,31)
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n/an/a 550n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
Briefly, 2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC...


US Patent US10266528 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM378853
PNG
(US10266528, Compound 7)
Show SMILES CC(C)(C)c1nnc(o1)C(=O)NCc1ccc(cc1F)-c1ccnc2[nH]c(=O)[nH]c12
Show InChI InChI=1S/C20H19FN6O3/c1-20(2,3)18-27-26-17(30-18)16(28)23-9-11-5-4-10(8-13(11)21)12-6-7-22-15-14(12)24-19(29)25-15/h4-8H,9H2,1-3H3,(H,23,28)(H2,22,24,25,29)
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n/an/a 550n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
Briefly, 2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC...


US Patent US10266528 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM378854
PNG
(US10266528, Compound 10)
Show SMILES CC(C)(C)c1noc(n1)C(=O)NCc1ccc(c(CO)c1)-c1ccnc2[nH]c(=O)[nH]c12
Show InChI InChI=1S/C21H22N6O4/c1-21(2,3)19-26-18(31-27-19)17(29)23-9-11-4-5-13(12(8-11)10-28)14-6-7-22-16-15(14)24-20(30)25-16/h4-8,28H,9-10H2,1-3H3,(H,23,29)(H2,22,24,25,30)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
Briefly, 2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC...


US Patent US10266528 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM378856
PNG
(US10266528, Compound 8)
Show SMILES CC(C)(C)c1ccc(cn1)C(=O)NCc1ccc(cc1F)-c1ccnc2[nH]c(=O)[nH]c12
Show InChI InChI=1S/C23H22FN5O2/c1-23(2,3)18-7-6-15(12-26-18)21(30)27-11-14-5-4-13(10-17(14)24)16-8-9-25-20-19(16)28-22(31)29-20/h4-10,12H,11H2,1-3H3,(H,27,30)(H2,25,28,29,31)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
Briefly, 2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC...


US Patent US10266528 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM378855
PNG
(US10266528, Compound 9)
Show SMILES CC(C)(O)c1ccc(cc1)C(=O)NCc1ccc(cc1F)-c1ccnc2[nH]c(=O)[nH]c12
Show InChI InChI=1S/C23H21FN4O3/c1-23(2,31)16-7-5-13(6-8-16)21(29)26-12-15-4-3-14(11-18(15)24)17-9-10-25-20-19(17)27-22(30)28-20/h3-11,31H,12H2,1-2H3,(H,26,29)(H2,25,27,28,30)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
Briefly, 2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC...


US Patent US10266528 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%