Search and Browse
Download
Enter Data
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM378893 (5,8-dichloro-2-((7-methyl-5-oxo-5,6-dihydro-1H-pyr...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | <0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Mirati Therapeutics, Inc. US Patent | Assay Description Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us... | US Patent US10266542 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM378912 (5,8-dichloro-7-[methoxy(oxetan-3-yl)methyl]-2-[(7-...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Mirati Therapeutics, Inc. US Patent | Assay Description Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us... | US Patent US10266542 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM378909 (5,8-dichloro-7-(3,5-dimethyltriazol-4-yl)-2-[(7-me...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Mirati Therapeutics, Inc. US Patent | Assay Description Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us... | US Patent US10266542 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM378907 (5,8-dichloro-7-(3,5-dimethylisoxazol-4-yl)-2-((7-m...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Mirati Therapeutics, Inc. US Patent | Assay Description Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us... | US Patent US10266542 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM378914 (5,8-dichloro-2-[(7-methyl-5-oxo-1,6-dihydropyrrolo...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Mirati Therapeutics, Inc. US Patent | Assay Description Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us... | US Patent US10266542 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM378913 (7-((5,8-dichloro-7-((1,1-dioxidothietan-3-yl)(meth...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Mirati Therapeutics, Inc. US Patent | Assay Description Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us... | US Patent US10266542 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM378911 (7-((5,8-dichloro-7-(3,5-dimethylisoxazol-4-yl)-1-o...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Mirati Therapeutics, Inc. US Patent | Assay Description Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us... | US Patent US10266542 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM378899 (7-[[5-bromo-8-chloro-7-(3,5-dimethyltriazol-4-yl)-...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Mirati Therapeutics, Inc. US Patent | Assay Description Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us... | US Patent US10266542 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM378903 (7-((5,8-dichloro-7-(methoxy(oxetan-3-yl)methyl)-1-...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Mirati Therapeutics, Inc. US Patent | Assay Description Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us... | US Patent US10266542 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM378886 (7-((5,8-dichloro-1-oxo-7-(7-oxa-2-azaspiro[3.5]non...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Mirati Therapeutics, Inc. US Patent | Assay Description Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us... | US Patent US10266542 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM378891 (7-((5,8-dichloro-7-(ethyl(tetrahydro-2H-pyran-4-yl...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Mirati Therapeutics, Inc. US Patent | Assay Description Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us... | US Patent US10266542 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM378861 (7-((5,8-dichloro-7-isopropoxy-1-oxo-3,4-dihydroiso...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Mirati Therapeutics, Inc. US Patent | Assay Description Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us... | US Patent US10266542 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM378895 (7-((8-chloro-7-isopropoxy-1-oxo-3,4-dihydroisoquin...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Mirati Therapeutics, Inc. US Patent | Assay Description Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us... | US Patent US10266542 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM378905 (5,8-dichloro-7-(methoxy(1-methylazetidin-3-yl)meth...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Mirati Therapeutics, Inc. US Patent | Assay Description Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us... | US Patent US10266542 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM378908 (7-((5,8-dichloro-7-(1,4-dimethyl-1H-1,2,3-triazol-...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Mirati Therapeutics, Inc. US Patent | Assay Description Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us... | US Patent US10266542 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM378904 (7-((5,8-dichloro-7-(methoxy(1-methylazetidin-3-yl)...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Mirati Therapeutics, Inc. US Patent | Assay Description Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us... | US Patent US10266542 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM378905 (5,8-dichloro-7-(methoxy(1-methylazetidin-3-yl)meth...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Mirati Therapeutics, Inc. US Patent | Assay Description Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us... | US Patent US10266542 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM378901 (7-((5,8-dichloro-7-isopropoxy-1-oxo-3,4-dihydroiso...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 95 | n/a | n/a | n/a | n/a | n/a | n/a |
Mirati Therapeutics, Inc. US Patent | Assay Description Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us... | US Patent US10266542 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM378892 (5,8-dichloro-7-isopropoxy-2-((7-methyl-5-oxo-5,6-d...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 202 | n/a | n/a | n/a | n/a | n/a | n/a |
Mirati Therapeutics, Inc. US Patent | Assay Description Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us... | US Patent US10266542 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
