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Patent code US10266549

Compile Data Set for Download or QSAR

Found 345 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379450
PNG
(US10266549, Example 349)
Show SMILES COc1ccc(Nc2ncc(c(NC3CC3)n2)C(F)(F)F)cc1OC
Show InChI InChI=1S/C16H17F3N4O2/c1-24-12-6-5-10(7-13(12)25-2)22-15-20-8-11(16(17,18)19)14(23-15)21-9-3-4-9/h5-9H,3-4H2,1-2H3,(H2,20,21,22,23)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379164
PNG
((E)-6-(4-Styryl-5-(trifluoromethyl)pyrimidin-2-yla...)
Show SMILES FC(F)(F)c1cnc(Nc2ccc3NC(=O)CCc3c2)nc1\C=C\c1ccccc1
Show InChI InChI=1S/C22H17F3N4O/c23-22(24,25)17-13-26-21(29-19(17)9-6-14-4-2-1-3-5-14)27-16-8-10-18-15(12-16)7-11-20(30)28-18/h1-6,8-10,12-13H,7,11H2,(H,28,30)(H,26,27,29)/b9-6+
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379216
PNG
(US10266549, Example 124*)
Show SMILES FC(F)(F)c1cnc(Nc2ccc3NC(=O)CCc3c2)nc1Nc1ccc2OCOc2c1
Show InChI InChI=1S/C21H16F3N5O3/c22-21(23,24)14-9-25-20(27-12-2-4-15-11(7-12)1-6-18(30)28-15)29-19(14)26-13-3-5-16-17(8-13)32-10-31-16/h2-5,7-9H,1,6,10H2,(H,28,30)(H2,25,26,27,29)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379218
PNG
(6-((4-((3,4-dimethylphenyl)amino)-5-(trifluorometh...)
Show SMILES Cc1ccc(Nc2nc(Nc3ccc4NC(=O)CCc4c3)ncc2C(F)(F)F)cc1C
Show InChI InChI=1S/C22H20F3N5O/c1-12-3-5-15(9-13(12)2)27-20-17(22(23,24)25)11-26-21(30-20)28-16-6-7-18-14(10-16)4-8-19(31)29-18/h3,5-7,9-11H,4,8H2,1-2H3,(H,29,31)(H2,26,27,28,30)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379228
PNG
(N-(4-((2-((2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)a...)
Show SMILES CC(=O)Nc1ccc(Nc2nc(Nc3ccc4NC(=O)CCc4c3)ncc2C(F)(F)F)cc1
Show InChI InChI=1S/C22H19F3N6O2/c1-12(32)27-14-3-5-15(6-4-14)28-20-17(22(23,24)25)11-26-21(31-20)29-16-7-8-18-13(10-16)2-9-19(33)30-18/h3-8,10-11H,2,9H2,1H3,(H,27,32)(H,30,33)(H2,26,28,29,31)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379249
PNG
(US10266549, Example 150b)
Show SMILES FC(F)(F)c1cnc(NC2CCC2)nc1Nc1ccc2NC(=O)CCc2c1
Show InChI InChI=1S/C18H18F3N5O/c19-18(20,21)13-9-22-17(24-11-2-1-3-11)26-16(13)23-12-5-6-14-10(8-12)4-7-15(27)25-14/h5-6,8-9,11H,1-4,7H2,(H,25,27)(H2,22,23,24,26)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379252
PNG
(US10266549, Example 152a)
Show SMILES FC(F)(F)c1cnc(Nc2cnc3[nH]ccc3c2)nc1NC1CC1
Show InChI InChI=1S/C15H13F3N6/c16-15(17,18)11-7-21-14(24-13(11)22-9-1-2-9)23-10-5-8-3-4-19-12(8)20-6-10/h3-7,9H,1-2H2,(H,19,20)(H2,21,22,23,24)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379293
PNG
(US10266549, Example 181a)
Show SMILES FC(F)(F)c1cnc(Nc2cnc3[nH]ccc3c2)nc1Nc1ccccc1
Show InChI InChI=1S/C18H13F3N6/c19-18(20,21)14-10-24-17(27-16(14)25-12-4-2-1-3-5-12)26-13-8-11-6-7-22-15(11)23-9-13/h1-10H,(H,22,23)(H2,24,25,26,27)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379308
PNG
(6-((5-bromo-2-((2,3-dihydrobenzo[b][1,4]dioxin-6-y...)
Show SMILES Brc1cnc(Nc2ccc3OCCOc3c2)nc1Nc1cnc2[nH]c(=O)oc2c1
Show InChI InChI=1S/C18H13BrN6O4/c19-11-8-21-17(23-9-1-2-12-13(5-9)28-4-3-27-12)24-15(11)22-10-6-14-16(20-7-10)25-18(26)29-14/h1-2,5-8H,3-4H2,(H,20,25,26)(H2,21,22,23,24)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379316
PNG
(6-((4-(2-ethylhydrazinyl)-5-(trifluoromethyl)pyrim...)
Show SMILES CCNNc1nc(Nc2ccc3NC(=O)CCc3c2)ncc1C(F)(F)F
Show InChI InChI=1S/C16H17F3N6O/c1-2-21-25-14-11(16(17,18)19)8-20-15(24-14)22-10-4-5-12-9(7-10)3-6-13(26)23-12/h4-5,7-8,21H,2-3,6H2,1H3,(H,23,26)(H2,20,22,24,25)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379320
PNG
(N4-cyclopropyl-N2-(pyrimidin-5-yl)-5-(trifluoromet...)
Show SMILES FC(F)(F)c1cnc(Nc2cncnc2)nc1NC1CC1
Show InChI InChI=1S/C12H11F3N6/c13-12(14,15)9-5-18-11(20-8-3-16-6-17-4-8)21-10(9)19-7-1-2-7/h3-7H,1-2H2,(H2,18,19,20,21)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379341
PNG
(US10266549, Example 220b)
Show SMILES CN(C)c1nc(Nc2ccc3NC(=O)CCc3c2)ncc1C(F)(F)F
Show InChI InChI=1S/C16H16F3N5O/c1-24(2)14-11(16(17,18)19)8-20-15(23-14)21-10-4-5-12-9(7-10)3-6-13(25)22-12/h4-5,7-8H,3,6H2,1-2H3,(H,22,25)(H,20,21,23)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379386
PNG
(5-bromo-4-(2-(methoxymethyl)phenoxy)-N-(3,4,5-trim...)
Show SMILES COCc1ccccc1Oc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Br
Show InChI InChI=1S/C21H22BrN3O5/c1-26-12-13-7-5-6-8-16(13)30-20-15(22)11-23-21(25-20)24-14-9-17(27-2)19(29-4)18(10-14)28-3/h5-11H,12H2,1-4H3,(H,23,24,25)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379397
PNG
(5-bromo-N4-phenyl-N2-(3,4,5-trimethoxyphenyl)pyrim...)
Show SMILES COc1cc(Nc2ncc(Br)c(Nc3ccccc3)n2)cc(OC)c1OC
Show InChI InChI=1S/C19H19BrN4O3/c1-25-15-9-13(10-16(26-2)17(15)27-3)23-19-21-11-14(20)18(24-19)22-12-7-5-4-6-8-12/h4-11H,1-3H3,(H2,21,22,23,24)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379401
PNG
(5-bromo-4-(2-(trifluoromethyl)phenoxy)-N-(3,4,5-tr...)
Show SMILES COc1cc(Nc2ncc(Br)c(Oc3ccccc3C(F)(F)F)n2)cc(OC)c1OC
Show InChI InChI=1S/C20H17BrF3N3O4/c1-28-15-8-11(9-16(29-2)17(15)30-3)26-19-25-10-13(21)18(27-19)31-14-7-5-4-6-12(14)20(22,23)24/h4-10H,1-3H3,(H,25,26,27)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379405
PNG
((2-((5-bromo-2-((3,4,5-trimethoxyphenyl)amino)pyri...)
Show SMILES COc1cc(Nc2ncc(Br)c(Nc3ccccc3CO)n2)cc(OC)c1OC
Show InChI InChI=1S/C20H21BrN4O4/c1-27-16-8-13(9-17(28-2)18(16)29-3)23-20-22-10-14(21)19(25-20)24-15-7-5-4-6-12(15)11-26/h4-10,26H,11H2,1-3H3,(H2,22,23,24,25)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379406
PNG
(US10266549, Example 304a)
Show SMILES Nc1ccc(Nc2ncc(c(NC3CC3)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C14H14F3N5/c15-14(16,17)11-7-19-13(22-12(11)20-9-5-6-9)21-10-3-1-8(18)2-4-10/h1-4,7,9H,5-6,18H2,(H2,19,20,21,22)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379415
PNG
(6-((4-((3-aminopropyl)amino)-5-(trifluoromethyl)py...)
Show SMILES NCCCNc1nc(Nc2ccc3NC(=O)CCc3c2)ncc1C(F)(F)F
Show InChI InChI=1S/C17H19F3N6O/c18-17(19,20)12-9-23-16(26-15(12)22-7-1-6-21)24-11-3-4-13-10(8-11)2-5-14(27)25-13/h3-4,8-9H,1-2,5-7,21H2,(H,25,27)(H2,22,23,24,26)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379441
PNG
(US10266549, Example 335b)
Show SMILES COc1cc(Nc2nc(Oc3cccc4CCCN(C(C)=O)c34)ncc2Br)cc(O)c1OC
Show InChI InChI=1S/C23H23BrN4O5/c1-13(29)28-9-5-7-14-6-4-8-18(20(14)28)33-23-25-12-16(24)22(27-23)26-15-10-17(30)21(32-3)19(11-15)31-2/h4,6,8,10-12,30H,5,7,9H2,1-3H3,(H,25,26,27)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379124
PNG
(2-(2-(1H-indol-5-ylamino)-5-bromopyrimidin-4-ylami...)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3[nH]ccc3c2)ncc1Br
Show InChI InChI=1S/C20H17BrN6O/c1-22-19(28)14-4-2-3-5-17(14)26-18-15(21)11-24-20(27-18)25-13-6-7-16-12(10-13)8-9-23-16/h2-11,23H,1H3,(H,22,28)(H2,24,25,26,27)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379167
PNG
(N-Methyl-2-(5-phenyl-2-(3,4,5-trimethoxyphenylamin...)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1-c1ccccc1
Show InChI InChI=1S/C27H27N5O4/c1-28-26(33)19-12-8-9-13-21(19)31-25-20(17-10-6-5-7-11-17)16-29-27(32-25)30-18-14-22(34-2)24(36-4)23(15-18)35-3/h5-16H,1-4H3,(H,28,33)(H2,29,30,31,32)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379180
PNG
(N-Methyl-2-(5-(trifluoromethyl)-2-(3,4,5-trimethox...)
Show SMILES CNC(=O)c1ccccc1Oc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1C(F)(F)F
Show InChI InChI=1S/C22H21F3N4O5/c1-26-19(30)13-7-5-6-8-15(13)34-20-14(22(23,24)25)11-27-21(29-20)28-12-9-16(31-2)18(33-4)17(10-12)32-3/h5-11H,1-4H3,(H,26,30)(H,27,28,29)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379223
PNG
(6-((4-((2,3-dihydro-1H-inden-5-yl)amino)-5-(triflu...)
Show SMILES FC(F)(F)c1cnc(Nc2ccc3NC(=O)CCc3c2)nc1Nc1ccc2CCCc2c1
Show InChI InChI=1S/C23H20F3N5O/c24-23(25,26)18-12-27-22(29-17-7-8-19-15(11-17)5-9-20(32)30-19)31-21(18)28-16-6-4-13-2-1-3-14(13)10-16/h4,6-8,10-12H,1-3,5,9H2,(H,30,32)(H2,27,28,29,31)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379224
PNG
(US10266549, Example 130a)
Show SMILES FC(F)(F)c1cnc(Nc2ccc3NC(=O)CCc3c2)nc1NC1Cc2ccccc2C1
Show InChI InChI=1S/C23H20F3N5O/c24-23(25,26)18-12-27-22(29-16-6-7-19-15(11-16)5-8-20(32)30-19)31-21(18)28-17-9-13-3-1-2-4-14(13)10-17/h1-4,6-7,11-12,17H,5,8-10H2,(H,30,32)(H2,27,28,29,31)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379234
PNG
(US10266549, Example 138*)
Show SMILES NC(=O)c1cccc(Nc2ncc(c(Nc3ccc4OCOc4c3)n2)C(F)(F)F)c1
Show InChI InChI=1S/C19H14F3N5O3/c20-19(21,22)13-8-24-18(26-11-3-1-2-10(6-11)16(23)28)27-17(13)25-12-4-5-14-15(7-12)30-9-29-14/h1-8H,9H2,(H2,23,28)(H2,24,25,26,27)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379238
PNG
(US10266549, Example 141b)
Show SMILES Fc1c(Nc2nc(Nc3ccc4OCOc4c3)ncc2C(F)(F)F)cccc1C(F)(F)F
Show InChI InChI=1S/C19H11F7N4O2/c20-15-10(18(21,22)23)2-1-3-12(15)29-16-11(19(24,25)26)7-27-17(30-16)28-9-4-5-13-14(6-9)32-8-31-13/h1-7H,8H2,(H2,27,28,29,30)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379239
PNG
(6-((5-bromo-4-((3-methoxyphenyl)amino)pyrimidin-2-...)
Show SMILES COc1cccc(Nc2nc(Nc3ccc4NC(=O)CCc4c3)ncc2Br)c1
Show InChI InChI=1S/C20H18BrN5O2/c1-28-15-4-2-3-13(10-15)23-19-16(21)11-22-20(26-19)24-14-6-7-17-12(9-14)5-8-18(27)25-17/h2-4,6-7,9-11H,5,8H2,1H3,(H,25,27)(H2,22,23,24,26)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379251
PNG
(US10266549, Example 151b)
Show SMILES COCCNc1ncc(c(Nc2ccc3NC(=O)CCc3c2)n1)C(F)(F)F
Show InChI InChI=1S/C17H18F3N5O2/c1-27-7-6-21-16-22-9-12(17(18,19)20)15(25-16)23-11-3-4-13-10(8-11)2-5-14(26)24-13/h3-4,8-9H,2,5-7H2,1H3,(H,24,26)(H2,21,22,23,25)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379276
PNG
(US10266549, Example 168a)
Show SMILES FC(F)(F)c1cnc(NC2CCC2)nc1Nc1ccc2OCOc2c1
Show InChI InChI=1S/C16H15F3N4O2/c17-16(18,19)11-7-20-15(22-9-2-1-3-9)23-14(11)21-10-4-5-12-13(6-10)25-8-24-12/h4-7,9H,1-3,8H2,(H2,20,21,22,23)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379177
PNG
(2-(5-Bromo-2-(3,4,5-trimethoxyphenylamino)pyrimidi...)
Show SMILES CNC(=O)c1ccccc1Oc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Br
Show InChI InChI=1S/C21H21BrN4O5/c1-23-19(27)13-7-5-6-8-15(13)31-20-14(22)11-24-21(26-20)25-12-9-16(28-2)18(30-4)17(10-12)29-3/h5-11H,1-4H3,(H,23,27)(H,24,25,26)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379285
PNG
(5-bromo-N4-cyclopropyl-N2-(1H-pyrrolo[2,3-b]pyridi...)
Show SMILES Brc1cnc(Nc2cnc3[nH]ccc3c2)nc1NC1CC1
Show InChI InChI=1S/C14H13BrN6/c15-11-7-18-14(21-13(11)19-9-1-2-9)20-10-5-8-3-4-16-12(8)17-6-10/h3-7,9H,1-2H2,(H,16,17)(H2,18,19,20,21)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379304
PNG
(5-bromo-N4-cyclopropyl-N2-(3,4,5-trimethoxyphenyl)...)
Show SMILES COc1cc(Nc2ncc(c(NC3CC3)n2)C(F)(F)F)cc(OC)c1OC
Show InChI InChI=1S/C17H19F3N4O3/c1-25-12-6-10(7-13(26-2)14(12)27-3)23-16-21-8-11(17(18,19)20)15(24-16)22-9-4-5-9/h6-9H,4-5H2,1-3H3,(H2,21,22,23,24)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379319
PNG
(6-((4-(cyclopropyl(methyl)amino)-5-(trifluoromethy...)
Show SMILES CN(C1CC1)c1nc(Nc2ccc3NC(=O)CCc3c2)ncc1C(F)(F)F
Show InChI InChI=1S/C18H18F3N5O/c1-26(12-4-5-12)16-13(18(19,20)21)9-22-17(25-16)23-11-3-6-14-10(8-11)2-7-15(27)24-14/h3,6,8-9,12H,2,4-5,7H2,1H3,(H,24,27)(H,22,23,25)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379343
PNG
(US10266549, Example 221a)
Show SMILES FC(F)(F)c1cnc(Nc2ccnnc2)nc1NC1CC1
Show InChI InChI=1S/C12H11F3N6/c13-12(14,15)9-6-16-11(20-8-3-4-17-18-5-8)21-10(9)19-7-1-2-7/h3-7H,1-2H2,(H2,16,17,19,20,21)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379351
PNG
(N4-cyclopropyl-N2-(6-methoxypyridin-2-yl)-5-(trifl...)
Show SMILES COc1cccc(Nc2ncc(c(NC3CC3)n2)C(F)(F)F)n1
Show InChI InChI=1S/C14H14F3N5O/c1-23-11-4-2-3-10(20-11)21-13-18-7-9(14(15,16)17)12(22-13)19-8-5-6-8/h2-4,7-8H,5-6H2,1H3,(H2,18,19,20,21,22)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379356
PNG
(5,5′-((5-bromopyrimidine-2,4-diyl)bis(azaned...)
Show SMILES Brc1cnc(Nc2ccc3[nH]c(=O)[nH]c3c2)nc1Nc1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C18H13BrN8O2/c19-10-7-20-16(22-9-2-4-12-14(6-9)26-18(29)24-12)27-15(10)21-8-1-3-11-13(5-8)25-17(28)23-11/h1-7H,(H2,23,25,28)(H2,24,26,29)(H2,20,21,22,27)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379371
PNG
(2-((5-bromo-2-((3,4,5-trimethoxyphenyl)amino)pyrim...)
Show SMILES CNC(=O)c1cccc(OC)c1Oc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Br
Show InChI InChI=1S/C22H23BrN4O6/c1-24-20(28)13-7-6-8-15(29-2)18(13)33-21-14(23)11-25-22(27-21)26-12-9-16(30-3)19(32-5)17(10-12)31-4/h6-11H,1-5H3,(H,24,28)(H,25,26,27)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379375
PNG
(2-((5-bromo-2-((3,4,5-trimethoxyphenyl)amino)pyrim...)
Show SMILES CNC(=O)c1c(O)cccc1Oc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Br
Show InChI InChI=1S/C21H21BrN4O6/c1-23-19(28)17-13(27)6-5-7-14(17)32-20-12(22)10-24-21(26-20)25-11-8-15(29-2)18(31-4)16(9-11)30-3/h5-10,27H,1-4H3,(H,23,28)(H,24,25,26)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379388
PNG
((2-((5-bromo-2-((3,4,5-trimethoxyphenyl)amino)pyri...)
Show SMILES COc1cc(Nc2ncc(Br)c(Oc3ccccc3C(=O)N3CCCC3)n2)cc(OC)c1OC
Show InChI InChI=1S/C24H25BrN4O5/c1-31-19-12-15(13-20(32-2)21(19)33-3)27-24-26-14-17(25)22(28-24)34-18-9-5-4-8-16(18)23(30)29-10-6-7-11-29/h4-5,8-9,12-14H,6-7,10-11H2,1-3H3,(H,26,27,28)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379400
PNG
(N2-(1H-benzo[d]imidazol-6-yl)-N4-(5-cyclobutyl-1H-...)
Show SMILES FC(F)(F)c1cnc(Nc2ccc3nc[nH]c3c2)nc1Nc1cc([nH]n1)C1CCC1
Show InChI InChI=1S/C19H17F3N8/c20-19(21,22)12-8-23-18(26-11-4-5-13-15(6-11)25-9-24-13)28-17(12)27-16-7-14(29-30-16)10-2-1-3-10/h4-10H,1-3H2,(H,24,25)(H3,23,26,27,28,29,30)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379408
PNG
(N4-cyclopropyl-N2-(quinoxalin-6-yl)-5-(trifluorome...)
Show SMILES FC(F)(F)c1cnc(Nc2ccc3nccnc3c2)nc1NC1CC1
Show InChI InChI=1S/C16H13F3N6/c17-16(18,19)11-8-22-15(25-14(11)23-9-1-2-9)24-10-3-4-12-13(7-10)21-6-5-20-12/h3-9H,1-2H2,(H2,22,23,24,25)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379115
PNG
(2-(5-Bromo-2-(3,4,5-trimethoxyphenylamino)pyrimidi...)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Br
Show InChI InChI=1S/C21H22BrN5O4/c1-23-20(28)13-7-5-6-8-15(13)26-19-14(22)11-24-21(27-19)25-12-9-16(29-2)18(31-4)17(10-12)30-3/h5-11H,1-4H3,(H,23,28)(H2,24,25,26,27)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379143
PNG
(6-(4-(Benzylamino)-5-(trifluoromethyl)pyrimidin-2-...)
Show SMILES FC(F)(F)c1cnc(Nc2ccc3NC(=O)CCc3c2)nc1NCc1ccccc1
Show InChI InChI=1S/C21H18F3N5O/c22-21(23,24)16-12-26-20(29-19(16)25-11-13-4-2-1-3-5-13)27-15-7-8-17-14(10-15)6-9-18(30)28-17/h1-5,7-8,10,12H,6,9,11H2,(H,28,30)(H2,25,26,27,29)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379158
PNG
(N-Methyl-2-(2-(3,4,5-trimethoxyphenylamino)pyrimid...)
Show SMILES CNC(=O)c1ccccc1Nc1ccnc(Nc2cc(OC)c(OC)c(OC)c2)n1
Show InChI InChI=1S/C21H23N5O4/c1-22-20(27)14-7-5-6-8-15(14)25-18-9-10-23-21(26-18)24-13-11-16(28-2)19(30-4)17(12-13)29-3/h5-12H,1-4H3,(H,22,27)(H2,23,24,25,26)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379222
PNG
(N-methyl-3-((2-((2-oxo-1,2,3,4-tetrahydroquinolin-...)
Show SMILES CNC(=O)c1cccc(Nc2nc(Nc3ccc4NC(=O)CCc4c3)ncc2C(F)(F)F)c1
Show InChI InChI=1S/C22H19F3N6O2/c1-26-20(33)13-3-2-4-14(10-13)28-19-16(22(23,24)25)11-27-21(31-19)29-15-6-7-17-12(9-15)5-8-18(32)30-17/h2-4,6-7,9-11H,5,8H2,1H3,(H,26,33)(H,30,32)(H2,27,28,29,31)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379230
PNG
(6,6′-((5-chloropyrimidine-2,4-diyl)bis(azane...)
Show SMILES Clc1cnc(Nc2ccc3NC(=O)CCc3c2)nc1Nc1ccc2NC(=O)CCc2c1
Show InChI InChI=1S/C22H19ClN6O2/c23-16-11-24-22(26-15-4-6-18-13(10-15)2-8-20(31)28-18)29-21(16)25-14-3-5-17-12(9-14)1-7-19(30)27-17/h3-6,9-11H,1-2,7-8H2,(H,27,30)(H,28,31)(H2,24,25,26,29)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379250
PNG
(US10266549, Example 151a)
Show SMILES COCCNc1nc(Nc2ccc3NC(=O)CCc3c2)ncc1C(F)(F)F
Show InChI InChI=1S/C17H18F3N5O2/c1-27-7-6-21-15-12(17(18,19)20)9-22-16(25-15)23-11-3-4-13-10(8-11)2-5-14(26)24-13/h3-4,8-9H,2,5-7H2,1H3,(H,24,26)(H2,21,22,23,25)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379274
PNG
(US10266549, Example 167a)
Show SMILES FC(F)(F)c1cnc(NCC2CC2)nc1Nc1ccc2OCOc2c1
Show InChI InChI=1S/C16H15F3N4O2/c17-16(18,19)11-7-21-15(20-6-9-1-2-9)23-14(11)22-10-3-4-12-13(5-10)25-8-24-12/h3-5,7,9H,1-2,6,8H2,(H2,20,21,22,23)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379286
PNG
(6-((4-cyclobutoxy-5-(trifluoromethyl)pyrimidin-2-y...)
Show SMILES FC(F)(F)c1cnc(Nc2ccc3NC(=O)CCc3c2)nc1OC1CCC1
Show InChI InChI=1S/C18H17F3N4O2/c19-18(20,21)13-9-22-17(25-16(13)27-12-2-1-3-12)23-11-5-6-14-10(8-11)4-7-15(26)24-14/h5-6,8-9,12H,1-4,7H2,(H,24,26)(H,22,23,25)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379336
PNG
(6-((4-((cyclopropylmethyl)amino)-5-(trifluoromethy...)
Show SMILES FC(F)(F)c1cnc(Nc2ccc3NC(=O)CCc3c2)nc1NCC1CC1
Show InChI InChI=1S/C18H18F3N5O/c19-18(20,21)13-9-23-17(26-16(13)22-8-10-1-2-10)24-12-4-5-14-11(7-12)3-6-15(27)25-14/h4-5,7,9-10H,1-3,6,8H2,(H,25,27)(H2,22,23,24,26)
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SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%