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Patent code US10266560

Compile Data Set for Download or QSAR
Found 65 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Bile acid receptor


(Homo sapiens (Human))		BDBM379473
PNG
(US10266560, Example 9)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H](C(C)CC(=O)NS(=O)(=O)CC=C)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C28H47NO5S/c1-6-14-35(33,34)29-24(31)15-17(3)20-8-9-21-25-22(11-13-27(20,21)4)28(5)12-10-18(30)16-23(28)19(7-2)26(25)32/h6,17-23,25-26,30,32H,1,7-16H2,2-5H3,(H,29,31)/t17?,18-,19-,20-,21+,22+,23+,25+,26-,27-,28-/m1/s1
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n/an/an/an/a 550n/an/an/an/a



Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379479
PNG
(US10266560, Example 10)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H](C(C)CC(=O)NS(=O)(=O)C(F)(F)F)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C26H42F3NO5S/c1-5-16-20-13-15(31)8-10-25(20,4)19-9-11-24(3)17(6-7-18(24)22(19)23(16)33)14(2)12-21(32)30-36(34,35)26(27,28)29/h14-20,22-23,31,33H,5-13H2,1-4H3,(H,30,32)/t14?,15-,16-,17-,18+,19+,20+,22+,23-,24-,25-/m1/s1
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n/an/an/an/a 5.50E+3n/an/an/an/a



Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379481
PNG
(US10266560, Example 12)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H](C(C)CC(=O)NS(=O)(=O)C4(C)CC4)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C29H49NO5S/c1-6-19-23-16-18(31)9-11-29(23,5)22-10-12-28(4)20(7-8-21(28)25(22)26(19)33)17(2)15-24(32)30-36(34,35)27(3)13-14-27/h17-23,25-26,31,33H,6-16H2,1-5H3,(H,30,32)/t17?,18-,19-,20-,21+,22+,23+,25+,26-,28-,29-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM350702
PNG
(US10208081, Example 10 | US10266560, Example 18)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)CCC(=O)NS(=O)(=O)c4ccccc4)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C32H49NO5S/c1-5-23-27-19-21(34)15-17-32(27,4)26-16-18-31(3)24(12-13-25(31)29(26)30(23)36)20(2)11-14-28(35)33-39(37,38)22-9-7-6-8-10-22/h6-10,20-21,23-27,29-30,34,36H,5,11-19H2,1-4H3,(H,33,35)/t20-,21-,23-,24-,25+,26+,27+,29+,30-,31-,32-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379503
PNG
(US10266560, Example 462)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4ccccn4)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C31H48N2O5S/c1-5-21-25-18-20(34)13-15-31(25,4)24-14-16-30(3)22(10-11-23(30)28(24)29(21)36)19(2)9-12-26(35)33-39(37,38)27-8-6-7-17-32-27/h6-8,17,19-25,28-29,34,36H,5,9-16,18H2,1-4H3,(H,33,35)/t19-,20-,21-,22?,23+,24+,25?,28+,29-,30?,31?/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379507
PNG
(US10266560, Example 466)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4cccnc4)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C31H48N2O5S/c1-5-22-26-17-20(34)12-14-31(26,4)25-13-15-30(3)23(9-10-24(30)28(25)29(22)36)19(2)8-11-27(35)33-39(37,38)21-7-6-16-32-18-21/h6-7,16,18-20,22-26,28-29,34,36H,5,8-15,17H2,1-4H3,(H,33,35)/t19-,20-,22-,23?,24+,25+,26?,28+,29-,30?,31?/m1/s1
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n/an/an/an/a 5.50E+3n/an/an/an/a



Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379511
PNG
(US10266560, Example 470)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4cccc5ncccc45)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C35H50N2O5S/c1-5-23-28-20-22(38)15-17-35(28,4)27-16-18-34(3)25(12-13-26(34)32(27)33(23)40)21(2)11-14-31(39)37-43(41,42)30-10-6-9-29-24(30)8-7-19-36-29/h6-10,19,21-23,25-28,32-33,38,40H,5,11-18,20H2,1-4H3,(H,37,39)/t21-,22-,23-,25?,26+,27+,28?,32+,33-,34?,35?/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379500
PNG
(US10266560, Example 459 | US10266560, Example 475)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4ccc(cc4)C(F)(F)F)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C33H48F3NO5S/c1-5-23-27-18-21(38)14-16-32(27,4)26-15-17-31(3)24(11-12-25(31)29(26)30(23)40)19(2)6-13-28(39)37-43(41,42)22-9-7-20(8-10-22)33(34,35)36/h7-10,19,21,23-27,29-30,38,40H,5-6,11-18H2,1-4H3,(H,37,39)/t19-,21-,23-,24?,25+,26+,27?,29+,30-,31?,32?/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379521
PNG
(US10266560, Example 480)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4ccc(Cl)cc4)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C32H48ClNO5S/c1-5-23-27-18-21(35)14-16-32(27,4)26-15-17-31(3)24(11-12-25(31)29(26)30(23)37)19(2)6-13-28(36)34-40(38,39)22-9-7-20(33)8-10-22/h7-10,19,21,23-27,29-30,35,37H,5-6,11-18H2,1-4H3,(H,34,36)/t19-,21-,23-,24?,25+,26+,27?,29+,30-,31?,32?/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379482
PNG
(US10266560, Example 14)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H](C(C)CC(=O)NS(=O)(=O)N4CCCC4)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C29H50N2O5S/c1-5-20-24-17-19(32)10-12-29(24,4)23-11-13-28(3)21(8-9-22(28)26(23)27(20)34)18(2)16-25(33)30-37(35,36)31-14-6-7-15-31/h18-24,26-27,32,34H,5-17H2,1-4H3,(H,30,33)/t18?,19-,20-,21-,22+,23+,24+,26+,27-,28-,29-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379495
PNG
(US10266560, Example 454)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4ccc(cc4)[N+]([O-])=O)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C32H48N2O7S/c1-5-23-27-18-21(35)14-16-32(27,4)26-15-17-31(3)24(11-12-25(31)29(26)30(23)37)19(2)6-13-28(36)33-42(40,41)22-9-7-20(8-10-22)34(38)39/h7-10,19,21,23-27,29-30,35,37H,5-6,11-18H2,1-4H3,(H,33,36)/t19-,21-,23-,24?,25+,26+,27?,29+,30-,31?,32?/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379499
PNG
(US10266560, Example 458)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4cn(C)cn4)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C30H49N3O5S/c1-6-20-24-15-19(34)11-13-30(24,4)23-12-14-29(3)21(8-9-22(29)27(23)28(20)36)18(2)7-10-25(35)32-39(37,38)26-16-33(5)17-31-26/h16-24,27-28,34,36H,6-15H2,1-5H3,(H,32,35)/t18-,19-,20-,21?,22+,23+,24?,27+,28-,29?,30?/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379517
PNG
(US10266560, Example 476)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4ccc(OC)c(F)c4)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C33H50FNO6S/c1-6-22-26-17-20(36)13-15-33(26,4)25-14-16-32(3)23(9-10-24(32)30(25)31(22)38)19(2)7-12-29(37)35-42(39,40)21-8-11-28(41-5)27(34)18-21/h8,11,18-20,22-26,30-31,36,38H,6-7,9-10,12-17H2,1-5H3,(H,35,37)/t19-,20-,22-,23?,24+,25+,26?,30+,31-,32?,33?/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379524
PNG
(US10266560, Example 483)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4cccc5ccccc45)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C36H51NO5S/c1-5-25-30-21-24(38)17-19-36(30,4)29-18-20-35(3)27(14-15-28(35)33(29)34(25)40)22(2)13-16-32(39)37-43(41,42)31-12-8-10-23-9-6-7-11-26(23)31/h6-12,22,24-25,27-30,33-34,38,40H,5,13-21H2,1-4H3,(H,37,39)/t22-,24-,25-,27?,28+,29+,30?,33+,34-,35?,36?/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379528
PNG
(US10266560, Example 487)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)C[C@@H](C)C(=O)NS(=O)(=O)c4ccc(OC(F)(F)F)cc4)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C34H50F3NO6S/c1-6-24-28-18-21(39)13-15-33(28,5)27-14-16-32(4)25(11-12-26(32)29(27)30(24)40)19(2)17-20(3)31(41)38-45(42,43)23-9-7-22(8-10-23)44-34(35,36)37/h7-10,19-21,24-30,39-40H,6,11-18H2,1-5H3,(H,38,41)/t19-,20-,21-,24-,25-,26+,27+,28+,29+,30-,32-,33-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379532
PNG
(US10266560, Example 491)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)CCCC(=O)NS(=O)(=O)c4ccc(cc4)C(C)(C)C)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C37H59NO5S/c1-8-27-31-22-25(39)18-20-37(31,7)30-19-21-36(6)28(16-17-29(36)33(30)34(27)41)23(2)10-9-11-32(40)38-44(42,43)26-14-12-24(13-15-26)35(3,4)5/h12-15,23,25,27-31,33-34,39,41H,8-11,16-22H2,1-7H3,(H,38,40)/t23-,25-,27-,28-,29+,30+,31+,33+,34-,36-,37-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM21675
PNG
((4R)-4-[(1S,2S,5R,7S,8R,9R,10S,11S,14R,15R)-8-ethy...)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)CCC(O)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C26H44O4/c1-5-17-21-14-16(27)10-12-26(21,4)20-11-13-25(3)18(15(2)6-9-22(28)29)7-8-19(25)23(20)24(17)30/h15-21,23-24,27,30H,5-14H2,1-4H3,(H,28,29)/t15-,16-,17-,18-,19+,20+,21+,23+,24-,25-,26-/m1/s1
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n/an/an/an/a 550n/an/an/an/a



Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Bile acid receptor


(Homo sapiens (Human))		BDBM379463
PNG
(US10266560, Example 1)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H](C(C)CC(=O)NS(C)(=O)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C26H45NO5S/c1-6-17-21-14-16(28)9-11-26(21,4)20-10-12-25(3)18(7-8-19(25)23(20)24(17)30)15(2)13-22(29)27-33(5,31)32/h15-21,23-24,28,30H,6-14H2,1-5H3,(H,27,29)/t15?,16-,17-,18-,19+,20+,21+,23+,24-,25-,26-/m1/s1
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n/an/an/an/a 550n/an/an/an/a



Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379467
PNG
(US10266560, Example 4)
Show SMILES CCCCS(=O)(=O)NC(=O)CC(C)[C@H]1CC[C@H]2[C@@H]3[C@H](O)[C@H](CC)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
Show InChI InChI=1S/C29H51NO5S/c1-6-8-15-36(34,35)30-25(32)16-18(3)21-9-10-22-26-23(12-14-28(21,22)4)29(5)13-11-19(31)17-24(29)20(7-2)27(26)33/h18-24,26-27,31,33H,6-17H2,1-5H3,(H,30,32)/t18?,19-,20-,21-,22+,23+,24+,26+,27-,28-,29-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379480
PNG
(US10266560, Example 11)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H](C(C)CC(=O)NS(=O)(=O)C4CC4)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C28H47NO5S/c1-5-19-23-15-17(30)10-12-28(23,4)22-11-13-27(3)20(8-9-21(27)25(22)26(19)32)16(2)14-24(31)29-35(33,34)18-6-7-18/h16-23,25-26,30,32H,5-15H2,1-4H3,(H,29,31)/t16?,17-,19-,20-,21+,22+,23+,25+,26-,27-,28-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379488
PNG
(US10266560, Example 22)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H](C(C)CC(=O)NS(=O)(=O)c4ccccc4F)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C31H46FNO5S/c1-5-20-24-17-19(34)12-14-31(24,4)23-13-15-30(3)21(10-11-22(30)28(23)29(20)36)18(2)16-27(35)33-39(37,38)26-9-7-6-8-25(26)32/h6-9,18-24,28-29,34,36H,5,10-17H2,1-4H3,(H,33,35)/t18?,19-,20-,21-,22+,23+,24+,28+,29-,30-,31-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379500
PNG
(US10266560, Example 459 | US10266560, Example 475)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4ccc(cc4)C(F)(F)F)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C33H48F3NO5S/c1-5-23-27-18-21(38)14-16-32(27,4)26-15-17-31(3)24(11-12-25(31)29(26)30(23)40)19(2)6-13-28(39)37-43(41,42)22-9-7-20(8-10-22)33(34,35)36/h7-10,19,21,23-27,29-30,38,40H,5-6,11-18H2,1-4H3,(H,37,39)/t19-,21-,23-,24?,25+,26+,27?,29+,30-,31?,32?/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379504
PNG
(US10266560, Example 463)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4ccncc4)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C31H48N2O5S/c1-5-22-26-18-20(34)10-14-31(26,4)25-11-15-30(3)23(7-8-24(30)28(25)29(22)36)19(2)6-9-27(35)33-39(37,38)21-12-16-32-17-13-21/h12-13,16-17,19-20,22-26,28-29,34,36H,5-11,14-15,18H2,1-4H3,(H,33,35)/t19-,20-,22-,23?,24+,25+,26?,28+,29-,30?,31?/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379505
PNG
(US10266560, Example 464)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4cc(F)cc(F)c4)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C32H47F2NO5S/c1-5-23-27-17-21(36)10-12-32(27,4)26-11-13-31(3)24(7-8-25(31)29(26)30(23)38)18(2)6-9-28(37)35-41(39,40)22-15-19(33)14-20(34)16-22/h14-16,18,21,23-27,29-30,36,38H,5-13,17H2,1-4H3,(H,35,37)/t18-,21-,23-,24?,25+,26+,27?,29+,30-,31?,32?/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379509
PNG
(US10266560, Example 468)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)C4CCCCC4)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C32H55NO5S/c1-5-23-27-19-21(34)15-17-32(27,4)26-16-18-31(3)24(12-13-25(31)29(26)30(23)36)20(2)11-14-28(35)33-39(37,38)22-9-7-6-8-10-22/h20-27,29-30,34,36H,5-19H2,1-4H3,(H,33,35)/t20-,21-,23-,24?,25+,26+,27?,29+,30-,31?,32?/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379519
PNG
(US10266560, Example 478)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4ccc(OC)c(OC)c4)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C34H53NO7S/c1-7-23-27-18-21(36)14-16-34(27,4)26-15-17-33(3)24(10-11-25(33)31(26)32(23)38)20(2)8-13-30(37)35-43(39,40)22-9-12-28(41-5)29(19-22)42-6/h9,12,19-21,23-27,31-32,36,38H,7-8,10-11,13-18H2,1-6H3,(H,35,37)/t20-,21-,23-,24?,25+,26+,27?,31+,32-,33?,34?/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379529
PNG
(US10266560, Example 488)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)C[C@H](C)C(=O)NS(=O)(=O)c4ccc(cc4)C(C)(C)C)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C37H59NO5S/c1-9-27-31-21-25(39)16-18-37(31,8)30-17-19-36(7)28(14-15-29(36)32(30)33(27)40)22(2)20-23(3)34(41)38-44(42,43)26-12-10-24(11-13-26)35(4,5)6/h10-13,22-23,25,27-33,39-40H,9,14-21H2,1-8H3,(H,38,41)/t22-,23+,25-,27-,28-,29+,30+,31+,32+,33-,36-,37-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379466
PNG
(US10266560, Example 3)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H](C(C)CC(=O)NS(=O)(=O)C(C)C)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C28H49NO5S/c1-7-19-23-15-18(30)10-12-28(23,6)22-11-13-27(5)20(8-9-21(27)25(22)26(19)32)17(4)14-24(31)29-35(33,34)16(2)3/h16-23,25-26,30,32H,7-15H2,1-6H3,(H,29,31)/t17?,18-,19-,20-,21+,22+,23+,25+,26-,27-,28-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379469
PNG
(US10266560, Example 5)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H](C(C)CC(=O)NS(=O)(=O)C(C)(C)C)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C29H51NO5S/c1-8-19-23-16-18(31)11-13-29(23,7)22-12-14-28(6)20(9-10-21(28)25(22)26(19)33)17(2)15-24(32)30-36(34,35)27(3,4)5/h17-23,25-26,31,33H,8-16H2,1-7H3,(H,30,32)/t17?,18-,19-,20-,21+,22+,23+,25+,26-,28-,29-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379487
PNG
(US10266560, Example 20)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H](C(C)CC(=O)NS(=O)(=O)c4ccccc4C)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C32H49NO5S/c1-6-22-26-18-21(34)13-15-32(26,5)25-14-16-31(4)23(11-12-24(31)29(25)30(22)36)20(3)17-28(35)33-39(37,38)27-10-8-7-9-19(27)2/h7-10,20-26,29-30,34,36H,6,11-18H2,1-5H3,(H,33,35)/t20?,21-,22-,23-,24+,25+,26+,29+,30-,31-,32-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379490
PNG
(US10266560, Example 24)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H](C(C)CC(=O)NS(=O)(=O)c4ccc(C)cc4)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C32H49NO5S/c1-6-23-27-18-21(34)13-15-32(27,5)26-14-16-31(4)24(11-12-25(31)29(26)30(23)36)20(3)17-28(35)33-39(37,38)22-9-7-19(2)8-10-22/h7-10,20-21,23-27,29-30,34,36H,6,11-18H2,1-5H3,(H,33,35)/t20?,21-,23-,24-,25+,26+,27+,29+,30-,31-,32-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379518
PNG
(US10266560, Example 477)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4cccc(OC)c4)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C33H51NO6S/c1-6-24-28-18-21(35)14-16-33(28,4)27-15-17-32(3)25(11-12-26(32)30(27)31(24)37)20(2)10-13-29(36)34-41(38,39)23-9-7-8-22(19-23)40-5/h7-9,19-21,24-28,30-31,35,37H,6,10-18H2,1-5H3,(H,34,36)/t20-,21-,24-,25?,26+,27+,28?,30+,31-,32?,33?/m1/s1
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n/an/an/an/a<100n/an/an/an/a



Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379520
PNG
(US10266560, Example 479)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4cccc(Cl)c4)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C32H48ClNO5S/c1-5-23-27-18-21(35)13-15-32(27,4)26-14-16-31(3)24(10-11-25(31)29(26)30(23)37)19(2)9-12-28(36)34-40(38,39)22-8-6-7-20(33)17-22/h6-8,17,19,21,23-27,29-30,35,37H,5,9-16,18H2,1-4H3,(H,34,36)/t19-,21-,23-,24?,25+,26+,27?,29+,30-,31?,32?/m1/s1
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n/an/an/an/a<100n/an/an/an/a



Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379523
PNG
(US10266560, Example 482)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)C4CCCC4)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C31H53NO5S/c1-5-22-26-18-20(33)14-16-31(26,4)25-15-17-30(3)23(11-12-24(30)28(25)29(22)35)19(2)10-13-27(34)32-38(36,37)21-8-6-7-9-21/h19-26,28-29,33,35H,5-18H2,1-4H3,(H,32,34)/t19-,20-,22-,23?,24+,25+,26?,28+,29-,30?,31?/m1/s1
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n/an/an/an/a<100n/an/an/an/a



Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379525
PNG
(US10266560, Example 484)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4ccc(cc4)C(C)(C)C)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C36H57NO5S/c1-8-26-30-21-24(38)17-19-36(30,7)29-18-20-35(6)27(14-15-28(35)32(29)33(26)40)22(2)9-16-31(39)37-43(41,42)25-12-10-23(11-13-25)34(3,4)5/h10-13,22,24,26-30,32-33,38,40H,8-9,14-21H2,1-7H3,(H,37,39)/t22-,24-,26-,27?,28+,29+,30?,32+,33-,35?,36?/m1/s1
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n/an/an/an/a<100n/an/an/an/a



Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379526
PNG
(US10266560, Example 485)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)C[C@@H](C)C(=O)NS(=O)(=O)c4ccc(cc4)C(C)(C)C)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C37H59NO5S/c1-9-27-31-21-25(39)16-18-37(31,8)30-17-19-36(7)28(14-15-29(36)32(30)33(27)40)22(2)20-23(3)34(41)38-44(42,43)26-12-10-24(11-13-26)35(4,5)6/h10-13,22-23,25,27-33,39-40H,9,14-21H2,1-8H3,(H,38,41)/t22-,23-,25-,27-,28-,29+,30+,31+,32+,33-,36-,37-/m1/s1
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n/an/an/an/a 550n/an/an/an/a



Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379527
PNG
(US10266560, Example 486)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)C[C@@H](C)C(=O)NS(=O)(=O)C4CC4)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C30H51NO5S/c1-6-21-25-16-19(32)11-13-30(25,5)24-12-14-29(4)22(9-10-23(29)26(24)27(21)33)17(2)15-18(3)28(34)31-37(35,36)20-7-8-20/h17-27,32-33H,6-16H2,1-5H3,(H,31,34)/t17-,18-,19-,21-,22-,23+,24+,25+,26+,27-,29-,30-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379533
PNG
(US10266560, Example 492)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)CCCC(=O)NS(=O)(=O)C4(C)CC4)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C31H53NO5S/c1-6-21-25-18-20(33)12-14-31(25,5)24-13-15-30(4)22(10-11-23(30)27(24)28(21)35)19(2)8-7-9-26(34)32-38(36,37)29(3)16-17-29/h19-25,27-28,33,35H,6-18H2,1-5H3,(H,32,34)/t19-,20-,21-,22-,23+,24+,25+,27+,28-,30-,31-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379470
PNG
(US10266560, Example 6)
Show SMILES CCCS(=O)(=O)NC(=O)CC(C)[C@H]1CC[C@H]2[C@@H]3[C@H](O)[C@H](CC)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
Show InChI InChI=1S/C28H49NO5S/c1-6-14-35(33,34)29-24(31)15-17(3)20-8-9-21-25-22(11-13-27(20,21)4)28(5)12-10-18(30)16-23(28)19(7-2)26(25)32/h17-23,25-26,30,32H,6-16H2,1-5H3,(H,29,31)/t17?,18-,19-,20-,21+,22+,23+,25+,26-,27-,28-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379491
PNG
(US10266560, Example 25)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H](C(C)CC(=O)NS(F)(=O)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C25H42FNO5S/c1-5-16-20-13-15(28)8-10-25(20,4)19-9-11-24(3)17(6-7-18(24)22(19)23(16)30)14(2)12-21(29)27-33(26,31)32/h14-20,22-23,28,30H,5-13H2,1-4H3,(H,27,29)/t14?,15-,16-,17-,18+,19+,20+,22+,23-,24-,25-/m1/s1
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n/an/an/an/a 5.50E+3n/an/an/an/a



Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379493
PNG
(US10266560, Example 452)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4cccc(c4)[N+]([O-])=O)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C32H48N2O7S/c1-5-23-27-18-21(35)13-15-32(27,4)26-14-16-31(3)24(10-11-25(31)29(26)30(23)37)19(2)9-12-28(36)33-42(40,41)22-8-6-7-20(17-22)34(38)39/h6-8,17,19,21,23-27,29-30,35,37H,5,9-16,18H2,1-4H3,(H,33,36)/t19-,21-,23-,24?,25+,26+,27?,29+,30-,31?,32?/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379497
PNG
(US10266560, Example 456)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4cccc(F)c4)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C32H48FNO5S/c1-5-23-27-18-21(35)13-15-32(27,4)26-14-16-31(3)24(10-11-25(31)29(26)30(23)37)19(2)9-12-28(36)34-40(38,39)22-8-6-7-20(33)17-22/h6-8,17,19,21,23-27,29-30,35,37H,5,9-16,18H2,1-4H3,(H,34,36)/t19-,21-,23-,24?,25+,26+,27?,29+,30-,31?,32?/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379508
PNG
(US10266560, Example 467)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4cccs4)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C30H47NO5S2/c1-5-20-24-17-19(32)12-14-30(24,4)23-13-15-29(3)21(9-10-22(29)27(23)28(20)34)18(2)8-11-25(33)31-38(35,36)26-7-6-16-37-26/h6-7,16,18-24,27-28,32,34H,5,8-15,17H2,1-4H3,(H,31,33)/t18-,19-,20-,21?,22+,23+,24?,27+,28-,29?,30?/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379512
PNG
(US10266560, Example 471)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4cccc(OC(F)(F)F)c4)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C33H48F3NO6S/c1-5-23-27-17-20(38)13-15-32(27,4)26-14-16-31(3)24(10-11-25(31)29(26)30(23)40)19(2)9-12-28(39)37-44(41,42)22-8-6-7-21(18-22)43-33(34,35)36/h6-8,18-20,23-27,29-30,38,40H,5,9-17H2,1-4H3,(H,37,39)/t19-,20-,23-,24?,25+,26+,27?,29+,30-,31?,32?/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379531
PNG
(US10266560, Example 490)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)CCCC(=O)NS(=O)(=O)C4CC4)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C30H51NO5S/c1-5-21-25-17-19(32)13-15-30(25,4)24-14-16-29(3)22(11-12-23(29)27(24)28(21)34)18(2)7-6-8-26(33)31-37(35,36)20-9-10-20/h18-25,27-28,32,34H,5-17H2,1-4H3,(H,31,33)/t18-,19-,21-,22-,23+,24+,25+,27+,28-,29-,30-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379472
PNG
(US10266560, Example 7)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H](C(C)CC(=O)NS(=O)(=O)Cc4ccccc4)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C32H49NO5S/c1-5-23-27-18-22(34)13-15-32(27,4)26-14-16-31(3)24(11-12-25(31)29(26)30(23)36)20(2)17-28(35)33-39(37,38)19-21-9-7-6-8-10-21/h6-10,20,22-27,29-30,34,36H,5,11-19H2,1-4H3,(H,33,35)/t20?,22-,23-,24-,25+,26+,27+,29+,30-,31-,32-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379484
PNG
(US10266560, Example 17)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H](C(C)CC(=O)NS(N)(=O)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C25H44N2O5S/c1-5-16-20-13-15(28)8-10-25(20,4)19-9-11-24(3)17(6-7-18(24)22(19)23(16)30)14(2)12-21(29)27-33(26,31)32/h14-20,22-23,28,30H,5-13H2,1-4H3,(H,27,29)(H2,26,31,32)/t14?,15-,16-,17-,18+,19+,20+,22+,23-,24-,25-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379486
PNG
(US10266560, Example 19)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H](C(C)CC(=O)NS(=O)(=O)c4ccccc4N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C31H48N2O5S/c1-5-20-24-17-19(34)12-14-31(24,4)23-13-15-30(3)21(10-11-22(30)28(23)29(20)36)18(2)16-27(35)33-39(37,38)26-9-7-6-8-25(26)32/h6-9,18-24,28-29,34,36H,5,10-17,32H2,1-4H3,(H,33,35)/t18?,19-,20-,21-,22+,23+,24+,28+,29-,30-,31-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379489
PNG
(US10266560, Example 23)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H](C(C)CC(=O)NS(=O)(=O)c4ccccc4[N+]([O-])=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C31H46N2O7S/c1-5-20-24-17-19(34)12-14-31(24,4)23-13-15-30(3)21(10-11-22(30)28(23)29(20)36)18(2)16-27(35)32-41(39,40)26-9-7-6-8-25(26)33(37)38/h6-9,18-24,28-29,34,36H,5,10-17H2,1-4H3,(H,32,35)/t18?,19-,20-,21-,22+,23+,24+,28+,29-,30-,31-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379506
PNG
(US10266560, Example 465)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4ccc(C)c(F)c4)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C33H50FNO5S/c1-6-23-27-17-21(36)13-15-33(27,5)26-14-16-32(4)24(10-11-25(32)30(26)31(23)38)19(2)8-12-29(37)35-41(39,40)22-9-7-20(3)28(34)18-22/h7,9,18-19,21,23-27,30-31,36,38H,6,8,10-17H2,1-5H3,(H,35,37)/t19-,21-,23-,24?,25+,26+,27?,30+,31-,32?,33?/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379514
PNG
(US10266560, Example 473)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4ccc(OC(F)(F)F)cc4)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C33H48F3NO6S/c1-5-23-27-18-20(38)14-16-32(27,4)26-15-17-31(3)24(11-12-25(31)29(26)30(23)40)19(2)6-13-28(39)37-44(41,42)22-9-7-21(8-10-22)43-33(34,35)36/h7-10,19-20,23-27,29-30,38,40H,5-6,11-18H2,1-4H3,(H,37,39)/t19-,20-,23-,24?,25+,26+,27?,29+,30-,31?,32?/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379483
PNG
(US10266560, Example 16)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H](C(C)CC(=O)NS(=O)(=O)N4CCOCC4)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C29H50N2O6S/c1-5-20-24-17-19(32)8-10-29(24,4)23-9-11-28(3)21(6-7-22(28)26(23)27(20)34)18(2)16-25(33)30-38(35,36)31-12-14-37-15-13-31/h18-24,26-27,32,34H,5-17H2,1-4H3,(H,30,33)/t18?,19-,20-,21-,22+,23+,24+,26+,27-,28-,29-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379498
PNG
(US10266560, Example 457)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4cccc(C)c4)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C33H51NO5S/c1-6-24-28-19-22(35)14-16-33(28,5)27-15-17-32(4)25(11-12-26(32)30(27)31(24)37)21(3)10-13-29(36)34-40(38,39)23-9-7-8-20(2)18-23/h7-9,18,21-22,24-28,30-31,35,37H,6,10-17,19H2,1-5H3,(H,34,36)/t21-,22-,24-,25?,26+,27+,28?,30+,31-,32?,33?/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379501
PNG
(US10266560, Example 460)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4cccc(c4)C(F)(F)F)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C33H48F3NO5S/c1-5-23-27-18-21(38)13-15-32(27,4)26-14-16-31(3)24(10-11-25(31)29(26)30(23)40)19(2)9-12-28(39)37-43(41,42)22-8-6-7-20(17-22)33(34,35)36/h6-8,17,19,21,23-27,29-30,38,40H,5,9-16,18H2,1-4H3,(H,37,39)/t19-,21-,23-,24?,25+,26+,27?,29+,30-,31?,32?/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379502
PNG
(US10266560, Example 461)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4ccc(cc4)C#N)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C33H48N2O5S/c1-5-24-28-18-22(36)14-16-33(28,4)27-15-17-32(3)25(11-12-26(32)30(27)31(24)38)20(2)6-13-29(37)35-41(39,40)23-9-7-21(19-34)8-10-23/h7-10,20,22,24-28,30-31,36,38H,5-6,11-18H2,1-4H3,(H,35,37)/t20-,22-,24-,25?,26+,27+,28?,30+,31-,32?,33?/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379510
PNG
(US10266560, Example 469)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4cnccn4)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C30H47N3O5S/c1-5-20-24-16-19(34)10-12-30(24,4)23-11-13-29(3)21(7-8-22(29)27(23)28(20)36)18(2)6-9-25(35)33-39(37,38)26-17-31-14-15-32-26/h14-15,17-24,27-28,34,36H,5-13,16H2,1-4H3,(H,33,35)/t18-,19-,20-,21?,22+,23+,24?,27+,28-,29?,30?/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379513
PNG
(US10266560, Example 472)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4ccc5ccccc5c4)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C36H51NO5S/c1-5-27-31-21-25(38)16-18-36(31,4)30-17-19-35(3)28(13-14-29(35)33(30)34(27)40)22(2)10-15-32(39)37-43(41,42)26-12-11-23-8-6-7-9-24(23)20-26/h6-9,11-12,20,22,25,27-31,33-34,38,40H,5,10,13-19,21H2,1-4H3,(H,37,39)/t22-,25-,27-,28?,29+,30+,31?,33+,34-,35?,36?/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379530
PNG
(US10266560, Example 489)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)CCC(=O)N(C)S(=O)(=O)c4ccccc4)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C33H51NO5S/c1-6-24-28-20-22(35)16-18-33(28,4)27-17-19-32(3)25(13-14-26(32)30(27)31(24)37)21(2)12-15-29(36)34(5)40(38,39)23-10-8-7-9-11-23/h7-11,21-22,24-28,30-31,35,37H,6,12-20H2,1-5H3/t21-,22-,24-,25-,26+,27+,28+,30+,31-,32-,33-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379113
PNG
(US10266560, Example CDCA | US10323060, Example CDC...)
Show SMILES C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)CC4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
Show InChI InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15?,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379464
PNG
(US10266560, Example 2)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H](C(C)CC(=O)NS(=O)(=O)CC)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C27H47NO5S/c1-6-18-22-15-17(29)10-12-27(22,5)21-11-13-26(4)19(8-9-20(26)24(21)25(18)31)16(3)14-23(30)28-34(32,33)7-2/h16-22,24-25,29,31H,6-15H2,1-5H3,(H,28,30)/t16?,17-,18-,19-,20+,21+,22+,24+,25-,26-,27-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379492
PNG
(US10266560, Example 451)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4ccccc4Cl)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C32H48ClNO5S/c1-5-21-25-18-20(35)14-16-32(25,4)24-15-17-31(3)22(11-12-23(31)29(24)30(21)37)19(2)10-13-28(36)34-40(38,39)27-9-7-6-8-26(27)33/h6-9,19-25,29-30,35,37H,5,10-18H2,1-4H3,(H,34,36)/t19-,20-,21-,22?,23+,24+,25?,29+,30-,31?,32?/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379494
PNG
(US10266560, Example 453)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4ccc(F)cc4)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C32H48FNO5S/c1-5-23-27-18-21(35)14-16-32(27,4)26-15-17-31(3)24(11-12-25(31)29(26)30(23)37)19(2)6-13-28(36)34-40(38,39)22-9-7-20(33)8-10-22/h7-10,19,21,23-27,29-30,35,37H,5-6,11-18H2,1-4H3,(H,34,36)/t19-,21-,23-,24?,25+,26+,27?,29+,30-,31?,32?/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379496
PNG
(US10266560, Example 455)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4ccc(OC)cc4)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C33H51NO6S/c1-6-24-28-19-21(35)15-17-33(28,4)27-16-18-32(3)25(12-13-26(32)30(27)31(24)37)20(2)7-14-29(36)34-41(38,39)23-10-8-22(40-5)9-11-23/h8-11,20-21,24-28,30-31,35,37H,6-7,12-19H2,1-5H3,(H,34,36)/t20-,21-,24-,25?,26+,27+,28?,30+,31-,32?,33?/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379515
PNG
(US10266560, Example 474)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4nccs4)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C29H46N2O5S2/c1-5-19-23-16-18(32)10-12-29(23,4)22-11-13-28(3)20(7-8-21(28)25(22)26(19)34)17(2)6-9-24(33)31-38(35,36)27-30-14-15-37-27/h14-15,17-23,25-26,32,34H,5-13,16H2,1-4H3,(H,31,33)/t17-,18-,19-,20?,21+,22+,23?,25+,26-,28?,29?/m1/s1
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n/an/an/an/a 5.50E+3n/an/an/an/a



Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM379522
PNG
(US10266560, Example 481)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CCC([C@H](C)CCC(=O)NS(=O)(=O)c4ccc5OCOc5c4)C3(C)CC[C@@H]2C2(C)CC[C@@H](O)CC12
Show InChI InChI=1S/C33H49NO7S/c1-5-22-26-16-20(35)12-14-33(26,4)25-13-15-32(3)23(8-9-24(32)30(25)31(22)37)19(2)6-11-29(36)34-42(38,39)21-7-10-27-28(17-21)41-18-40-27/h7,10,17,19-20,22-26,30-31,35,37H,5-6,8-9,11-16,18H2,1-4H3,(H,34,36)/t19-,20-,22-,23?,24+,25+,26?,30+,31-,32?,33?/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<100n/an/an/an/a



Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...

US Patent US10266560 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GSP
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%