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Patent code US10272074

Compile Data Set for Download or QSAR

Found 477 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381450
PNG
(4-chloro-1-(pyridin-3-ylmethyl)-N-(4-(trifluoromet...)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2cnc3n(Cc4cccnc4)ncc3c2Cl)cc1
Show InChI InChI=1S/C20H13ClF3N5O/c21-17-15-10-27-29(11-12-2-1-7-25-8-12)18(15)26-9-16(17)19(30)28-14-5-3-13(4-6-14)20(22,23)24/h1-10H,11H2,(H,28,30)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381453
PNG
(4-chloro-1-(pyridin-2-ylmethyl)-N-(4-(trifluoromet...)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2cnc3n(Cc4ccccn4)ncc3c2Cl)cc1
Show InChI InChI=1S/C20H13ClF3N5O/c21-17-15-10-27-29(11-14-3-1-2-8-25-14)18(15)26-9-16(17)19(30)28-13-6-4-12(5-7-13)20(22,23)24/h1-10H,11H2,(H,28,30)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381464
PNG
(4-chloro-N-(4-isopropylphenyl)-1- ((1-methyl-1H-im...)
Show SMILES CC(C)c1ccc(NC(=O)c2cnc3n(Cc4cncn4C)ncc3c2Cl)cc1
Show InChI InChI=1S/C21H21ClN6O/c1-13(2)14-4-6-15(7-5-14)26-21(29)18-9-24-20-17(19(18)22)10-25-28(20)11-16-8-23-12-27(16)3/h4-10,12-13H,11H2,1-3H3,(H,26,29)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381543
PNG
(4-Chloro-3-methyl-1-thiazol-4- ylmethyl-1H-pyrazol...)
Show SMILES Cc1nn(Cc2cscn2)c2ncc(C(=O)Nc3ccc(cc3)C(F)(F)F)c(Cl)c12
Show InChI InChI=1S/C19H13ClF3N5OS/c1-10-15-16(20)14(6-24-17(15)28(27-10)7-13-8-30-9-25-13)18(29)26-12-4-2-11(3-5-12)19(21,22)23/h2-6,8-9H,7H2,1H3,(H,26,29)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381604
PNG
(4-Chloro-1-(5,6-dihydro-4H- pyrrolo[1,2-b]pyrazol-...)
Show SMILES Cc1nn(Cc2cc3CCCn3n2)c2ncc(C(=O)Nc3ccc(cc3)C(F)(F)F)c(Cl)c12
Show InChI InChI=1S/C22H18ClF3N6O/c1-12-18-19(23)17(21(33)28-14-6-4-13(5-7-14)22(24,25)26)10-27-20(18)32(29-12)11-15-9-16-3-2-8-31(16)30-15/h4-7,9-10H,2-3,8,11H2,1H3,(H,28,33)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381174
PNG
(4-Chloro-3-methyl-1-phenyl-1H- pyrazolo[3,4-b]pyri...)
Show SMILES CC(C)c1ccc(NC(=O)c2cnc3n(nc(C)c3c2Cl)-c2ccccc2)cc1
Show InChI InChI=1S/C23H21ClN4O/c1-14(2)16-9-11-17(12-10-16)26-23(29)19-13-25-22-20(21(19)24)15(3)27-28(22)18-7-5-4-6-8-18/h4-14H,1-3H3,(H,26,29)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381181
PNG
(4-Chloro-3-methyl-1-phenyl-1H- pyrazolo[3,4-b]pyri...)
Show SMILES COCc1ccc(NC(=O)c2cnc3n(nc(C)c3c2Cl)-c2ccccc2)cc1
Show InChI InChI=1S/C22H19ClN4O2/c1-14-19-20(23)18(22(28)25-16-10-8-15(9-11-16)13-29-2)12-24-21(19)27(26-14)17-6-4-3-5-7-17/h3-12H,13H2,1-2H3,(H,25,28)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381317
PNG
(4-chloro-1-(2-methoxyethyl)-3- methyl-N-(4- (trifl...)
Show SMILES COCCn1nc(C)c2c(Cl)c(cnc12)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C18H16ClF3N4O2/c1-10-14-15(19)13(9-23-16(14)26(25-10)7-8-28-2)17(27)24-12-5-3-11(4-6-12)18(20,21)22/h3-6,9H,7-8H2,1-2H3,(H,24,27)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381368
PNG
(4-chloro-N-(4-chlorophenyl)-1- (1,1-dioxidotetrahy...)
Show SMILES Cc1nn(C2CCS(=O)(=O)CC2)c2ncc(C(=O)Nc3ccc(Cl)cc3)c(Cl)c12
Show InChI InChI=1S/C19H18Cl2N4O3S/c1-11-16-17(21)15(19(26)23-13-4-2-12(20)3-5-13)10-22-18(16)25(24-11)14-6-8-29(27,28)9-7-14/h2-5,10,14H,6-9H2,1H3,(H,23,26)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381373
PNG
(4-Chloro-1-(1-ethyl-piperidin-4- yl)-1H-pyrazolo[3...)
Show SMILES CCN1CCC(CC1)n1ncc2c(Cl)c(cnc12)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H21ClF3N5O/c1-2-29-9-7-15(8-10-29)30-19-16(12-27-30)18(22)17(11-26-19)20(31)28-14-5-3-13(4-6-14)21(23,24)25/h3-6,11-12,15H,2,7-10H2,1H3,(H,28,31)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381377
PNG
(4-chloro-1-(1-methyl-piperidin-4- yl)-1H-pyrazolo[...)
Show SMILES CN1CCC(CC1)n1ncc2c(Cl)c(cnc12)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C20H19ClF3N5O/c1-28-8-6-14(7-9-28)29-18-15(11-26-29)17(21)16(10-25-18)19(30)27-13-4-2-12(3-5-13)20(22,23)24/h2-5,10-11,14H,6-9H2,1H3,(H,27,30)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381379
PNG
(4-Chloro-1-(tetrahydro-pyran-4- yl)-1H-pyrazolo[3,...)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2cnc3n(ncc3c2Cl)C2CCOCC2)cc1
Show InChI InChI=1S/C19H16ClF3N4O2/c20-16-14-10-25-27(13-5-7-29-8-6-13)17(14)24-9-15(16)18(28)26-12-3-1-11(2-4-12)19(21,22)23/h1-4,9-10,13H,5-8H2,(H,26,28)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381398
PNG
(4-chloro-N-(4-chlorophenyl)-3- methyl-1-(pyridin-4...)
Show SMILES Cc1nn(Cc2ccncc2)c2ncc(C(=O)Nc3ccc(Cl)cc3)c(Cl)c12
Show InChI InChI=1S/C20H15Cl2N5O/c1-12-17-18(22)16(20(28)25-15-4-2-14(21)3-5-15)10-24-19(17)27(26-12)11-13-6-8-23-9-7-13/h2-10H,11H2,1H3,(H,25,28)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381399
PNG
(4-chloro-3-methyl-1-(pyridin-4- ylmethyl)-N-(4- (t...)
Show SMILES Cc1nn(Cc2ccncc2)c2ncc(C(=O)Nc3ccc(cc3)C(F)(F)F)c(Cl)c12
Show InChI InChI=1S/C21H15ClF3N5O/c1-12-17-18(22)16(20(31)28-15-4-2-14(3-5-15)21(23,24)25)10-27-19(17)30(29-12)11-13-6-8-26-9-7-13/h2-10H,11H2,1H3,(H,28,31)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381413
PNG
(4-Chloro-3-methyl-1-(6-methyl- pyridin-3-methyl)-1...)
Show SMILES Cc1nn(Cc2ccc(C)nc2)c2ncc(C(=O)Nc3ccc(cc3)C(F)(F)F)c(Cl)c12
Show InChI InChI=1S/C22H17ClF3N5O/c1-12-3-4-14(9-27-12)11-31-20-18(13(2)30-31)19(23)17(10-28-20)21(32)29-16-7-5-15(6-8-16)22(24,25)26/h3-10H,11H2,1-2H3,(H,29,32)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381532
PNG
(4-Chloro-1-(6-methoxy-pyrimidin- 4-ylmethyl)-3-met...)
Show SMILES COc1cc(Cn2nc(C)c3c(Cl)c(cnc23)C(=O)Nc2ccc(cc2)C(F)(F)F)ncn1
Show InChI InChI=1S/C21H16ClF3N6O2/c1-11-17-18(22)15(20(32)29-13-5-3-12(4-6-13)21(23,24)25)8-26-19(17)31(30-11)9-14-7-16(33-2)28-10-27-14/h3-8,10H,9H2,1-2H3,(H,29,32)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381546
PNG
(4-Chloro-3-methyl-1-(2-piperazin- 1-yl-ethyl)-1H-p...)
Show SMILES Cc1nn(CCN2CCNCC2)c2ncc(C(=O)Nc3ccc(cc3)C(F)(F)F)c(Cl)c12
Show InChI InChI=1S/C21H22ClF3N6O/c1-13-17-18(22)16(20(32)28-15-4-2-14(3-5-15)21(23,24)25)12-27-19(17)31(29-13)11-10-30-8-6-26-7-9-30/h2-5,12,26H,6-11H2,1H3,(H,28,32)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381556
PNG
(1-[2-(4-Acetyl-piperazin-1-yl)- ethyl]-4-chloro-3-...)
Show SMILES CC(=O)N1CCN(CCn2nc(C)c3c(Cl)c(cnc23)C(=O)Nc2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C22H24Cl2N6O2/c1-14-19-20(24)18(22(32)26-17-5-3-16(23)4-6-17)13-25-21(19)30(27-14)12-9-28-7-10-29(11-8-28)15(2)31/h3-6,13H,7-12H2,1-2H3,(H,26,32)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381310
PNG
(4-Chloro-1-ethyl-3-methyl-1H- pyrazolo[3,4-b]pyrid...)
Show SMILES CCn1nc(C)c2c(Cl)c(cnc12)C(=O)Nc1ccc(cc1)C(C)C
Show InChI InChI=1S/C19H21ClN4O/c1-5-24-18-16(12(4)23-24)17(20)15(10-21-18)19(25)22-14-8-6-13(7-9-14)11(2)3/h6-11H,5H2,1-4H3,(H,22,25)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381320
PNG
(4-Chloro-1-(3-methoxy-propyl)-3- methyl-1H-pyrazol...)
Show SMILES COCCCn1nc(C)c2c(Cl)c(cnc12)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H18ClF3N4O2/c1-11-15-16(20)14(10-24-17(15)27(26-11)8-3-9-29-2)18(28)25-13-6-4-12(5-7-13)19(21,22)23/h4-7,10H,3,8-9H2,1-2H3,(H,25,28)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381360
PNG
(1-(1-acetylpiperidin-4-yl)-4-chloro- 3-methyl-N-(4...)
Show SMILES CC(=O)N1CCC(CC1)n1nc(C)c2c(Cl)c(cnc12)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C22H21ClF3N5O2/c1-12-18-19(23)17(21(33)28-15-5-3-14(4-6-15)22(24,25)26)11-27-20(18)31(29-12)16-7-9-30(10-8-16)13(2)32/h3-6,11,16H,7-10H2,1-2H3,(H,28,33)
PDB

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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381378
PNG
(4-Chloro-1-(tetrahydro-pyran-4- yl)-1H-pyrazolo[3,...)
Show SMILES Clc1ccc(NC(=O)c2cnc3n(ncc3c2Cl)C2CCOCC2)cc1
Show InChI InChI=1S/C18H16Cl2N4O2/c19-11-1-3-12(4-2-11)23-18(25)15-9-21-17-14(16(15)20)10-22-24(17)13-5-7-26-8-6-13/h1-4,9-10,13H,5-8H2,(H,23,25)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381387
PNG
(4-Chloro-3-fluoro-1-(tetrahydro- pyran-4-yl)-1H-py...)
Show SMILES Fc1nn(C2CCOCC2)c2ncc(C(=O)Nc3ccc(Cl)cc3)c(Cl)c12
Show InChI InChI=1S/C18H15Cl2FN4O2/c19-10-1-3-11(4-2-10)23-18(26)13-9-22-17-14(15(13)20)16(21)24-25(17)12-5-7-27-8-6-12/h1-4,9,12H,5-8H2,(H,23,26)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381396
PNG
(4-chloro-1-(1,1-dioxidotetrahydro- 2H-thiopyran-4-...)
Show SMILES CC(C)c1ccc(NC(=O)c2cnc3n(ncc3c2Cl)C2CCS(=O)(=O)CC2)cc1
Show InChI InChI=1S/C21H23ClN4O3S/c1-13(2)14-3-5-15(6-4-14)25-21(27)18-11-23-20-17(19(18)22)12-24-26(20)16-7-9-30(28,29)10-8-16/h3-6,11-13,16H,7-10H2,1-2H3,(H,25,27)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381527
PNG
(4-Chloro-3-methyl-1-(6-methyl- pyrimidin-4-ylmethy...)
Show SMILES CC(C)c1ccc(NC(=O)c2cnc3n(Cc4cc(C)ncn4)nc(C)c3c2Cl)cc1
Show InChI InChI=1S/C23H23ClN6O/c1-13(2)16-5-7-17(8-6-16)28-23(31)19-10-25-22-20(21(19)24)15(4)29-30(22)11-18-9-14(3)26-12-27-18/h5-10,12-13H,11H2,1-4H3,(H,28,31)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381528
PNG
(4-Chloro-3-methyl-1-(6-methyl- pyrimidin-4-ylmethy...)
Show SMILES COc1ccc(NC(=O)c2cnc3n(Cc4cc(C)ncn4)nc(C)c3c2Cl)cc1
Show InChI InChI=1S/C21H19ClN6O2/c1-12-8-15(25-11-24-12)10-28-20-18(13(2)27-28)19(22)17(9-23-20)21(29)26-14-4-6-16(30-3)7-5-14/h4-9,11H,10H2,1-3H3,(H,26,29)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381553
PNG
(4-Chloro-1-[2-(4-methanesulfonyl- piperazin-1-yl)-...)
Show SMILES Cc1nn(CCN2CCN(CC2)S(C)(=O)=O)c2ncc(C(=O)Nc3ccc(cc3)C(F)(F)F)c(Cl)c12
Show InChI InChI=1S/C22H24ClF3N6O3S/c1-14-18-19(23)17(21(33)28-16-5-3-15(4-6-16)22(24,25)26)13-27-20(18)32(29-14)12-9-30-7-10-31(11-8-30)36(2,34)35/h3-6,13H,7-12H2,1-2H3,(H,28,33)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381555
PNG
(1-[2-(4-Acetyl-piperazin-1-yl)- ethyl]-4-chloro-3-...)
Show SMILES CC(=O)N1CCN(CCn2nc(C)c3c(Cl)c(cnc23)C(=O)Nc2ccc(cc2)C(F)(F)F)CC1
Show InChI InChI=1S/C23H24ClF3N6O2/c1-14-19-20(24)18(22(35)29-17-5-3-16(4-6-17)23(25,26)27)13-28-21(19)33(30-14)12-9-31-7-10-32(11-8-31)15(2)34/h3-6,13H,7-12H2,1-2H3,(H,29,35)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381593
PNG
(4-chloro-3-methyl-1-((5-methyl- 1H-1,2,3-triazol-4...)
Show SMILES Cc1nn(Cc2nn[nH]c2C)c2ncc(C(=O)Nc3ccc(cc3)C(F)(F)F)c(Cl)c12
Show InChI InChI=1S/C19H15ClF3N7O/c1-9-14(27-29-26-9)8-30-17-15(10(2)28-30)16(20)13(7-24-17)18(31)25-12-5-3-11(4-6-12)19(21,22)23/h3-7H,8H2,1-2H3,(H,25,31)(H,26,27,29)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381619
PNG
(4-Chloro-1-(1H-imidazol-2- ylmethyl)-3-methyl-1H- ...)
Show SMILES Cc1nn(Cc2ncc[nH]2)c2ncc(C(=O)Nc3ccc(Cl)cc3)c(Cl)c12
Show InChI InChI=1S/C18H14Cl2N6O/c1-10-15-16(20)13(18(27)24-12-4-2-11(19)3-5-12)8-23-17(15)26(25-10)9-14-21-6-7-22-14/h2-8H,9H2,1H3,(H,21,22)(H,24,27)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381259
PNG
(4-Chloro-1,3-dimethyl-1H- pyrazolo[3,4-b]pyridine-...)
Show SMILES Cc1nn(C)c2ncc(C(=O)Nc3cccc(Br)c3)c(Cl)c12
Show InChI InChI=1S/C15H12BrClN4O/c1-8-12-13(17)11(7-18-14(12)21(2)20-8)15(22)19-10-5-3-4-9(16)6-10/h3-7H,1-2H3,(H,19,22)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381293
PNG
(4-Chloro-1-methyl-1H- pyrazolo[3,4-b]pyridine-5- c...)
Show SMILES Cn1ncc2c(Cl)c(cnc12)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C14H10Cl2N4O/c1-20-13-10(7-18-20)12(16)11(6-17-13)14(21)19-9-4-2-8(15)3-5-9/h2-7H,1H3,(H,19,21)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381322
PNG
(4-chloro-1-(3-methoxy-propyl)-3- methyl-1H-pyrazol...)
Show SMILES COCCCn1nc(C)c2c(Cl)c(cnc12)C(=O)Nc1ccc(cc1)C(C)C
Show InChI InChI=1S/C21H25ClN4O2/c1-13(2)15-6-8-16(9-7-15)24-21(27)17-12-23-20-18(19(17)22)14(3)25-26(20)10-5-11-28-4/h6-9,12-13H,5,10-11H2,1-4H3,(H,24,27)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381335
PNG
(4-Chloro-3-methyl-1-(tetrahydro- pyran-4-yl)-1H-py...)
Show SMILES CC(C)c1ccc(NC(=O)c2cnc3n(nc(C)c3c2Cl)C2CCOCC2)cc1
Show InChI InChI=1S/C22H25ClN4O2/c1-13(2)15-4-6-16(7-5-15)25-22(28)18-12-24-21-19(20(18)23)14(3)26-27(21)17-8-10-29-11-9-17/h4-7,12-13,17H,8-11H2,1-3H3,(H,25,28)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381345
PNG
(4-chloro-N-(4-chlorophenyl)-3- methyl-1-(1-methylp...)
Show SMILES CN1CCC(CC1)n1nc(C)c2c(Cl)c(cnc12)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C20H21Cl2N5O/c1-12-17-18(22)16(20(28)24-14-5-3-13(21)4-6-14)11-23-19(17)27(25-12)15-7-9-26(2)10-8-15/h3-6,11,15H,7-10H2,1-2H3,(H,24,28)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381353
PNG
(1-(1-benzylpiperidin-4-yl)-4- chloro-3-methyl-N-(4...)
Show SMILES Cc1nn(C2CCN(Cc3ccccc3)CC2)c2ncc(C(=O)Nc3ccc(cc3)C(F)(F)F)c(Cl)c12
Show InChI InChI=1S/C27H25ClF3N5O/c1-17-23-24(28)22(26(37)33-20-9-7-19(8-10-20)27(29,30)31)15-32-25(23)36(34-17)21-11-13-35(14-12-21)16-18-5-3-2-4-6-18/h2-10,15,21H,11-14,16H2,1H3,(H,33,37)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381366
PNG
(4-chloro-3-methyl-1-(tetrahydro- 2H-thiopyran-4-yl...)
Show SMILES Cc1nn(C2CCSCC2)c2ncc(C(=O)Nc3ccc(cc3)C(F)(F)F)c(Cl)c12
Show InChI InChI=1S/C20H18ClF3N4OS/c1-11-16-17(21)15(10-25-18(16)28(27-11)14-6-8-30-9-7-14)19(29)26-13-4-2-12(3-5-13)20(22,23)24/h2-5,10,14H,6-9H2,1H3,(H,26,29)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381390
PNG
(4-chloro-1-(tetrahydro-2H- thiopyran-4-yl)-N-(4- (...)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2cnc3n(ncc3c2Cl)C2CCSCC2)cc1
Show InChI InChI=1S/C19H16ClF3N4OS/c20-16-14-10-25-27(13-5-7-29-8-6-13)17(14)24-9-15(16)18(28)26-12-3-1-11(2-4-12)19(21,22)23/h1-4,9-10,13H,5-8H2,(H,26,28)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381397
PNG
(4-chloro-1-(1,1-dioxidotetrahydro- 2H-thiopyran-4-...)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2cnc3n(ncc3c2Cl)C2CCS(=O)(=O)CC2)cc1
Show InChI InChI=1S/C19H16ClF3N4O3S/c20-16-14-10-25-27(13-5-7-31(29,30)8-6-13)17(14)24-9-15(16)18(28)26-12-3-1-11(2-4-12)19(21,22)23/h1-4,9-10,13H,5-8H2,(H,26,28)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381415
PNG
(4-Chloro-1-(5-methoxy-pyridin-2- ylmethyl)-3-methy...)
Show SMILES COc1ccc(Cn2nc(C)c3c(Cl)c(cnc23)C(=O)Nc2ccc(cc2)C(F)(F)F)nc1
Show InChI InChI=1S/C22H17ClF3N5O2/c1-12-18-19(23)17(21(32)29-14-5-3-13(4-6-14)22(24,25)26)10-28-20(18)31(30-12)11-15-7-8-16(33-2)9-27-15/h3-10H,11H2,1-2H3,(H,29,32)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381439
PNG
(4-chloro-N-(4-chlorophenyl)-1-((1- ethyl-1H-imidaz...)
Show SMILES CCn1ccnc1Cn1nc(C)c2c(Cl)c(cnc12)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C20H18Cl2N6O/c1-3-27-9-8-23-16(27)11-28-19-17(12(2)26-28)18(22)15(10-24-19)20(29)25-14-6-4-13(21)5-7-14/h4-10H,3,11H2,1-2H3,(H,25,29)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381448
PNG
(4-chloro-N-(4-isopropylphenyl)-1-(pyridin-4-ylmeth...)
Show SMILES CC(C)c1ccc(NC(=O)c2cnc3n(Cc4ccncc4)ncc3c2Cl)cc1
Show InChI InChI=1S/C22H20ClN5O/c1-14(2)16-3-5-17(6-4-16)27-22(29)19-11-25-21-18(20(19)23)12-26-28(21)13-15-7-9-24-10-8-15/h3-12,14H,13H2,1-2H3,(H,27,29)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381510
PNG
(4-Chloro-3-methyl-1-(2-morpholin- 4-yl-ethyl)-1H-p...)
Show SMILES Cc1nn(CCN2CCOCC2)c2ncc(C(=O)Nc3ccc(cc3)C(F)(F)F)c(Cl)c12
Show InChI InChI=1S/C21H21ClF3N5O2/c1-13-17-18(22)16(20(31)27-15-4-2-14(3-5-15)21(23,24)25)12-26-19(17)30(28-13)7-6-29-8-10-32-11-9-29/h2-5,12H,6-11H2,1H3,(H,27,31)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381511
PNG
(4-Chloro-3-methyl-1-(2-morpholin- 4-yl-ethyl)-1H-p...)
Show SMILES CC(C)c1ccc(NC(=O)c2cnc3n(CCN4CCOCC4)nc(C)c3c2Cl)cc1
Show InChI InChI=1S/C23H28ClN5O2/c1-15(2)17-4-6-18(7-5-17)26-23(30)19-14-25-22-20(21(19)24)16(3)27-29(22)9-8-28-10-12-31-13-11-28/h4-7,14-15H,8-13H2,1-3H3,(H,26,30)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381530
PNG
(4-Chloro-1-(3,4-dimethoxy- pyridin-2-ylmethyl)-3-m...)
Show SMILES COc1ccnc(Cn2nc(C)c3c(Cl)c(cnc23)C(=O)Nc2ccc(cc2)C(F)(F)F)c1OC
Show InChI InChI=1S/C23H19ClF3N5O3/c1-12-18-19(24)15(22(33)30-14-6-4-13(5-7-14)23(25,26)27)10-29-21(18)32(31-12)11-16-20(35-3)17(34-2)8-9-28-16/h4-10H,11H2,1-3H3,(H,30,33)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381537
PNG
(4-Chloro-3-methyl-1-oxazol-2- ylmethyl-1H-pyrazolo...)
Show SMILES Cc1nn(Cc2ncco2)c2ncc(C(=O)Nc3ccc(Cl)cc3)c(Cl)c12
Show InChI InChI=1S/C18H13Cl2N5O2/c1-10-15-16(20)13(18(26)23-12-4-2-11(19)3-5-12)8-22-17(15)25(24-10)9-14-21-6-7-27-14/h2-8H,9H2,1H3,(H,23,26)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381354
PNG
(1-(1-benzylpiperidin-4-yl)-4- chloro-N-(4-isopropy...)
Show SMILES CC(C)c1ccc(NC(=O)c2cnc3n(nc(C)c3c2Cl)C2CCN(Cc3ccccc3)CC2)cc1
Show InChI InChI=1S/C29H32ClN5O/c1-19(2)22-9-11-23(12-10-22)32-29(36)25-17-31-28-26(27(25)30)20(3)33-35(28)24-13-15-34(16-14-24)18-21-7-5-4-6-8-21/h4-12,17,19,24H,13-16,18H2,1-3H3,(H,32,36)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381635
PNG
(4-chloro-N-(4-isopropylphenyl)-1- (piperidin-4-yl)...)
Show SMILES CC(C)c1ccc(NC(=O)c2cnc3n(ncc3c2Cl)C2CCNCC2)cc1
Show InChI InChI=1S/C21H24ClN5O/c1-13(2)14-3-5-15(6-4-14)26-21(28)18-11-24-20-17(19(18)22)12-25-27(20)16-7-9-23-10-8-16/h3-6,11-13,16,23H,7-10H2,1-2H3,(H,26,28)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381641
PNG
(4-chloro-N-(4-isopropylphenyl)-3- methyl-1-(piperi...)
Show SMILES CC(C)c1ccc(NC(=O)c2cnc3n(nc(C)c3c2Cl)C2CCNCC2)cc1
Show InChI InChI=1S/C22H26ClN5O/c1-13(2)15-4-6-16(7-5-15)26-22(29)18-12-25-21-19(20(18)23)14(3)27-28(21)17-8-10-24-11-9-17/h4-7,12-13,17,24H,8-11H2,1-3H3,(H,26,29)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM381239
PNG
(4-Chloro-1-(4-dimethylamino- phenyl)-3-methyl-1H-p...)
Show SMILES CN(C)c1ccc(cc1)-n1nc(C)c2c(Cl)c(cnc12)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C22H19Cl2N5O/c1-13-19-20(24)18(22(30)26-15-6-4-14(23)5-7-15)12-25-21(19)29(27-13)17-10-8-16(9-11-17)28(2)3/h4-12H,1-3H3,(H,26,30)
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n/an/a<50n/an/an/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...


US Patent US10272074 (2019)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%