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Patent code US10273214

Compile Data Set for Download or QSAR
Found 78 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM50436102
PNG
(CHEMBL2397256 | US10273214, Example 1180-26)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)ccc23)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1/C25H24ClNO4/c1-29-20-6-8-21(9-7-20)31-16-24-23-11-10-22(30-2)15-17(23)12-13-27(24)25(28)18-4-3-5-19(26)14-18/h3-11,14-15,24H,12-13,16H2,1-2H3
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n/an/a 800n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM50436102
PNG
(CHEMBL2397256 | US10273214, Example 1180-26)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)ccc23)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1/C25H24ClNO4/c1-29-20-6-8-21(9-7-20)31-16-24-23-11-10-22(30-2)15-17(23)12-13-27(24)25(28)18-4-3-5-19(26)14-18/h3-11,14-15,24H,12-13,16H2,1-2H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Emory University

US Patent




US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM50436101
PNG
(CHEMBL2397257 | US10273214, Example 1180-27)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)ccc23)C(=O)c2cccc(Br)c2)cc1
Show InChI InChI=1/C25H24BrNO4/c1-29-20-6-8-21(9-7-20)31-16-24-23-11-10-22(30-2)15-17(23)12-13-27(24)25(28)18-4-3-5-19(26)14-18/h3-11,14-15,24H,12-13,16H2,1-2H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Emory University

US Patent




US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM50436101
PNG
(CHEMBL2397257 | US10273214, Example 1180-27)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)ccc23)C(=O)c2cccc(Br)c2)cc1
Show InChI InChI=1/C25H24BrNO4/c1-29-20-6-8-21(9-7-20)31-16-24-23-11-10-22(30-2)15-17(23)12-13-27(24)25(28)18-4-3-5-19(26)14-18/h3-11,14-15,24H,12-13,16H2,1-2H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM50436082
PNG
(CHEMBL2397103 | US10273214, Example 1391)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(Br)c2)cc1
Show InChI InChI=1/C26H26BrNO5/c1-30-20-7-9-21(10-8-20)33-16-23-22-15-25(32-3)24(31-2)14-17(22)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM50436090
PNG
(CHEMBL2397119 | US10273214, Example 1180-31)
Show SMILES COc1ccc(\C=C\C2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1/C27H26ClNO4/c1-31-22-10-7-18(8-11-22)9-12-24-23-17-26(33-3)25(32-2)16-19(23)13-14-29(24)27(30)20-5-4-6-21(28)15-20/h4-12,15-17,24H,13-14H2,1-3H3/b12-9+
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n/an/a 1.20E+3n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM50436090
PNG
(CHEMBL2397119 | US10273214, Example 1180-31)
Show SMILES COc1ccc(\C=C\C2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1/C27H26ClNO4/c1-31-22-10-7-18(8-11-22)9-12-24-23-17-26(33-3)25(32-2)16-19(23)13-14-29(24)27(30)20-5-4-6-21(28)15-20/h4-12,15-17,24H,13-14H2,1-3H3/b12-9+
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n/an/a 1.50E+3n/an/an/an/an/an/a



Emory University

US Patent




US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM50436078
PNG
(CHEMBL2397109 | US10273214, Example 1180-12)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(Cl)c2Cl)cc1
Show InChI InChI=1/C26H25Cl2NO5/c1-31-17-7-9-18(10-8-17)34-15-22-20-14-24(33-3)23(32-2)13-16(20)11-12-29(22)26(30)19-5-4-6-21(27)25(19)28/h4-10,13-14,22H,11-12,15H2,1-3H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM50436072
PNG
(CHEMBL2397211 | US10273214, Example 1426)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1/C27H26F3NO5/c1-33-20-7-9-21(10-8-20)36-16-23-22-15-25(35-3)24(34-2)14-17(22)11-12-31(23)26(32)18-5-4-6-19(13-18)27(28,29)30/h4-10,13-15,23H,11-12,16H2,1-3H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM50436082
PNG
(CHEMBL2397103 | US10273214, Example 1391)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(Br)c2)cc1
Show InChI InChI=1/C26H26BrNO5/c1-30-20-7-9-21(10-8-20)33-16-23-22-15-25(32-3)24(31-2)14-17(22)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Emory University

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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM50436072
PNG
(CHEMBL2397211 | US10273214, Example 1426)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1/C27H26F3NO5/c1-33-20-7-9-21(10-8-20)36-16-23-22-15-25(35-3)24(34-2)14-17(22)11-12-31(23)26(32)18-5-4-6-19(13-18)27(28,29)30/h4-10,13-15,23H,11-12,16H2,1-3H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Emory University

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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM50436085
PNG
(CHEMBL2397093 | US10273214, Example 1180-15)
Show SMILES COc1ccc(OC[C@H]2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1/C26H26ClNO5/c1-30-20-7-9-21(10-8-20)33-16-23-22-15-25(32-3)24(31-2)14-17(22)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3/t23-/s2
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n/an/a 2.40E+3n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM50436067
PNG
(CHEMBL2397233 | US10273214, Example 1366)
Show SMILES CCc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2ccccc2)cc1
Show InChI InChI=1/C27H29NO4/c1-4-19-10-12-22(13-11-19)32-18-24-23-17-26(31-3)25(30-2)16-21(23)14-15-28(24)27(29)20-8-6-5-7-9-20/h5-13,16-17,24H,4,14-15,18H2,1-3H3
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n/an/a 3.00E+3n/an/an/an/an/an/a



Emory University

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Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM50436060
PNG
(CHEMBL2397100 | US10273214, Example 1390)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1/C26H26ClNO5/c1-30-20-7-9-21(10-8-20)33-16-23-22-15-25(32-3)24(31-2)14-17(22)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3
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n/an/a 3.00E+3n/an/an/an/an/an/a



Emory University

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Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM50436060
PNG
(CHEMBL2397100 | US10273214, Example 1390)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1/C26H26ClNO5/c1-30-20-7-9-21(10-8-20)33-16-23-22-15-25(32-3)24(31-2)14-17(22)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3
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Emory University

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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM50436079
PNG
(CHEMBL2397108 | US10273214, Example 1180-10)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1/C26H25Cl2NO5/c1-31-18-5-7-19(8-6-18)34-15-23-20-14-25(33-3)24(32-2)13-16(20)10-11-29(23)26(30)17-4-9-21(27)22(28)12-17/h4-9,12-14,23H,10-11,15H2,1-3H3
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n/an/a 3.00E+3n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM50436085
PNG
(CHEMBL2397093 | US10273214, Example 1180-15)
Show SMILES COc1ccc(OC[C@H]2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1/C26H26ClNO5/c1-30-20-7-9-21(10-8-20)33-16-23-22-15-25(32-3)24(31-2)14-17(22)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3/t23-/s2
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n/an/a 4.00E+3n/an/an/an/an/an/a



Emory University

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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM50436061
PNG
(CHEMBL2397099 | US10273214, Example 1368)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2ccc(Cl)cc2)cc1
Show InChI InChI=1/C26H26ClNO5/c1-30-20-8-10-21(11-9-20)33-16-23-22-15-25(32-3)24(31-2)14-18(22)12-13-28(23)26(29)17-4-6-19(27)7-5-17/h4-11,14-15,23H,12-13,16H2,1-3H3
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n/an/a 4.00E+3n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM50436083
PNG
(CHEMBL2397097 | US10273214, Example 1425)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(C)c2)cc1
Show InChI InChI=1/C27H29NO5/c1-18-6-5-7-20(14-18)27(29)28-13-12-19-15-25(31-3)26(32-4)16-23(19)24(28)17-33-22-10-8-21(30-2)9-11-22/h5-11,14-16,24H,12-13,17H2,1-4H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM50436083
PNG
(CHEMBL2397097 | US10273214, Example 1425)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(C)c2)cc1
Show InChI InChI=1/C27H29NO5/c1-18-6-5-7-20(14-18)27(29)28-13-12-19-15-25(31-3)26(32-4)16-23(19)24(28)17-33-22-10-8-21(30-2)9-11-22/h5-11,14-16,24H,12-13,17H2,1-4H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



Emory University

US Patent




US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM50436061
PNG
(CHEMBL2397099 | US10273214, Example 1368)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2ccc(Cl)cc2)cc1
Show InChI InChI=1/C26H26ClNO5/c1-30-20-8-10-21(11-9-20)33-16-23-22-15-25(32-3)24(31-2)14-18(22)12-13-28(23)26(29)17-4-6-19(27)7-5-17/h4-11,14-15,23H,12-13,16H2,1-3H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



Emory University

US Patent




US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM50436081
PNG
(CHEMBL2397105 | US10273214, Example 1392)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(OC)c2)cc1
Show InChI InChI=1/C27H29NO6/c1-30-20-8-10-21(11-9-20)34-17-24-23-16-26(33-4)25(32-3)15-18(23)12-13-28(24)27(29)19-6-5-7-22(14-19)31-2/h5-11,14-16,24H,12-13,17H2,1-4H3
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n/an/a 6.00E+3n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM50436076
PNG
(CHEMBL2397124 | US10273214, Example 1180-18)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2ccc(F)c(Cl)c2)cc1
Show InChI InChI=1/C26H25ClFNO5/c1-31-18-5-7-19(8-6-18)34-15-23-20-14-25(33-3)24(32-2)13-16(20)10-11-29(23)26(30)17-4-9-22(28)21(27)12-17/h4-9,12-14,23H,10-11,15H2,1-3H3
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Emory University

US Patent


Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM50436069
PNG
(CHEMBL2397221 | US10273214, Example 1486)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccs2)cc1
Show InChI InChI=1/C24H25NO5S/c1-27-17-6-8-18(9-7-17)30-15-20-19-14-22(29-3)21(28-2)13-16(19)10-11-25(20)24(26)23-5-4-12-31-23/h4-9,12-14,20H,10-11,15H2,1-3H3
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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM50436076
PNG
(CHEMBL2397124 | US10273214, Example 1180-18)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2ccc(F)c(Cl)c2)cc1
Show InChI InChI=1/C26H25ClFNO5/c1-31-18-5-7-19(8-6-18)34-15-23-20-14-25(33-3)24(32-2)13-16(20)10-11-29(23)26(30)17-4-9-22(28)21(27)12-17/h4-9,12-14,23H,10-11,15H2,1-3H3
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Emory University

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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM50436064
PNG
(CHEMBL2397250 | US10273214, Example 1180-25)
Show SMILES COc1ccc(OCC2N(CCc3cc4OCOc4cc23)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1/C25H22ClNO5/c1-29-19-5-7-20(8-6-19)30-14-22-21-13-24-23(31-15-32-24)12-16(21)9-10-27(22)25(28)17-3-2-4-18(26)11-17/h2-8,11-13,22H,9-10,14-15H2,1H3
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Emory University

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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM50436075
PNG
(CHEMBL2397208 | US10273214, Example 1369)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(F)c2)cc1
Show InChI InChI=1/C26H26FNO5/c1-30-20-7-9-21(10-8-20)33-16-23-22-15-25(32-3)24(31-2)14-17(22)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3
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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM50436104
PNG
(CHEMBL2397254 | US10273214, Example 1180-21)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)cc(OC)c23)C(=O)c2cccc(Br)c2)cc1
Show InChI InChI=1/C26H26BrNO5/c1-30-20-7-9-21(10-8-20)33-16-23-25-17(14-22(31-2)15-24(25)32-3)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3
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n/an/a 7.00E+3n/an/an/an/an/an/a



Emory University

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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM50436075
PNG
(CHEMBL2397208 | US10273214, Example 1369)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(F)c2)cc1
Show InChI InChI=1/C26H26FNO5/c1-30-20-7-9-21(10-8-20)33-16-23-22-15-25(32-3)24(31-2)14-17(22)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3
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Emory University

US Patent


Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM50436104
PNG
(CHEMBL2397254 | US10273214, Example 1180-21)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)cc(OC)c23)C(=O)c2cccc(Br)c2)cc1
Show InChI InChI=1/C26H26BrNO5/c1-30-20-7-9-21(10-8-20)33-16-23-25-17(14-22(31-2)15-24(25)32-3)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3
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Emory University

US Patent


Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM50436079
PNG
(CHEMBL2397108 | US10273214, Example 1180-10)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1/C26H25Cl2NO5/c1-31-18-5-7-19(8-6-18)34-15-23-20-14-25(33-3)24(32-2)13-16(20)10-11-29(23)26(30)17-4-9-21(27)22(28)12-17/h4-9,12-14,23H,10-11,15H2,1-3H3
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n/an/a 8.00E+3n/an/an/an/an/an/a



Emory University

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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM50436062
PNG
(CHEMBL2397252 | US10273214, Example 1180-19)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)cc(OC)c23)C(=O)c2ccccc2)cc1
Show InChI InChI=1/C26H27NO5/c1-29-20-9-11-21(12-10-20)32-17-23-25-19(15-22(30-2)16-24(25)31-3)13-14-27(23)26(28)18-7-5-4-6-8-18/h4-12,15-16,23H,13-14,17H2,1-3H3
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n/an/a 9.00E+3n/an/an/an/an/an/a



Emory University

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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM50436069
PNG
(CHEMBL2397221 | US10273214, Example 1486)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccs2)cc1
Show InChI InChI=1/C24H25NO5S/c1-27-17-6-8-18(9-7-17)30-15-20-19-14-22(29-3)21(28-2)13-16(19)10-11-25(20)24(26)23-5-4-12-31-23/h4-9,12-14,20H,10-11,15H2,1-3H3
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Emory University

US Patent


Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM50436062
PNG
(CHEMBL2397252 | US10273214, Example 1180-19)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)cc(OC)c23)C(=O)c2ccccc2)cc1
Show InChI InChI=1/C26H27NO5/c1-29-20-9-11-21(12-10-20)32-17-23-25-19(15-22(30-2)16-24(25)31-3)13-14-27(23)26(28)18-7-5-4-6-8-18/h4-12,15-16,23H,13-14,17H2,1-3H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM50436084
PNG
(CHEMBL2397095 | US10273214, Example 1180)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2ccccc2)cc1
Show InChI InChI=1/C26H27NO5/c1-29-20-9-11-21(12-10-20)32-17-23-22-16-25(31-3)24(30-2)15-19(22)13-14-27(23)26(28)18-7-5-4-6-8-18/h4-12,15-16,23H,13-14,17H2,1-3H3
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n/an/a 1.10E+4n/an/an/an/an/an/a



Emory University

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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM50436105
PNG
(CHEMBL2397253 | US10273214, Example 1180-20)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)cc(OC)c23)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1/C26H26ClNO5/c1-30-20-7-9-21(10-8-20)33-16-23-25-17(14-22(31-2)15-24(25)32-3)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3
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Emory University

US Patent


Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM381963
PNG
(US10273214, Example 1434)
Show SMILES Cc1ccc(cc1)-c1csc(NC(=O)c2ccc(cc2)C(C)(C)C)c1C(O)=O
Show InChI InChI=1S/C23H23NO3S/c1-14-5-7-15(8-6-14)18-13-28-21(19(18)22(26)27)24-20(25)16-9-11-17(12-10-16)23(2,3)4/h5-13H,1-4H3,(H,24,25)(H,26,27)
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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM50436084
PNG
(CHEMBL2397095 | US10273214, Example 1180)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2ccccc2)cc1
Show InChI InChI=1/C26H27NO5/c1-29-20-9-11-21(12-10-20)32-17-23-22-16-25(31-3)24(30-2)15-19(22)13-14-27(23)26(28)18-7-5-4-6-8-18/h4-12,15-16,23H,13-14,17H2,1-3H3
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n/an/a 1.20E+4n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM50436081
PNG
(CHEMBL2397105 | US10273214, Example 1392)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(OC)c2)cc1
Show InChI InChI=1/C27H29NO6/c1-30-20-8-10-21(11-9-20)34-17-24-23-16-26(33-4)25(32-3)15-18(23)12-13-28(24)27(29)19-6-5-7-22(14-19)31-2/h5-11,14-16,24H,12-13,17H2,1-4H3
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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM50436064
PNG
(CHEMBL2397250 | US10273214, Example 1180-25)
Show SMILES COc1ccc(OCC2N(CCc3cc4OCOc4cc23)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1/C25H22ClNO5/c1-29-19-5-7-20(8-6-19)30-14-22-21-13-24-23(31-15-32-24)12-16(21)9-10-27(22)25(28)17-3-2-4-18(26)11-17/h2-8,11-13,22H,9-10,14-15H2,1H3
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Emory University

US Patent


Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM50436080
PNG
(CHEMBL2397107 | US10273214, Example 1180-16)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(c2)[N+]([O-])=O)cc1
Show InChI InChI=1/C26H26N2O7/c1-32-20-7-9-21(10-8-20)35-16-23-22-15-25(34-3)24(33-2)14-17(22)11-12-27(23)26(29)18-5-4-6-19(13-18)28(30)31/h4-10,13-15,23H,11-12,16H2,1-3H3
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n/an/a 1.30E+4n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM381963
PNG
(US10273214, Example 1434)
Show SMILES Cc1ccc(cc1)-c1csc(NC(=O)c2ccc(cc2)C(C)(C)C)c1C(O)=O
Show InChI InChI=1S/C23H23NO3S/c1-14-5-7-15(8-6-14)18-13-28-21(19(18)22(26)27)24-20(25)16-9-11-17(12-10-16)23(2,3)4/h5-13H,1-4H3,(H,24,25)(H,26,27)
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n/an/a 1.60E+4n/an/an/an/an/an/a



Emory University

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Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM50436080
PNG
(CHEMBL2397107 | US10273214, Example 1180-16)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(c2)[N+]([O-])=O)cc1
Show InChI InChI=1/C26H26N2O7/c1-32-20-7-9-21(10-8-20)35-16-23-22-15-25(34-3)24(33-2)14-17(22)11-12-27(23)26(29)18-5-4-6-19(13-18)28(30)31/h4-10,13-15,23H,11-12,16H2,1-3H3
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n/an/a 1.60E+4n/an/an/an/an/an/a



Emory University

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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM381957
PNG
(US10273214, Example 1417)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)Nc1sc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C20H23NO3S/c1-20(2,3)13-10-8-12(9-11-13)17(22)21-18-16(19(23)24)14-6-4-5-7-15(14)25-18/h8-11H,4-7H2,1-3H3,(H,21,22)(H,23,24)
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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM381958
PNG
(US10273214, Example 1482)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)NC1=C(C2CCCCCC2S1)C(O)=O
Show InChI InChI=1S/C21H27NO3S/c1-21(2,3)14-11-9-13(10-12-14)18(23)22-19-17(20(24)25)15-7-5-4-6-8-16(15)26-19/h9-12,15-16H,4-8H2,1-3H3,(H,22,23)(H,24,25)
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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM381961
PNG
(US10273214, Example 1423)
Show SMILES CCOc1ccc(cc1)-c1csc(NC(=O)c2ccc(cc2)C(C)(C)C)c1C(O)=O
Show InChI InChI=1S/C24H25NO4S/c1-5-29-18-12-8-15(9-13-18)19-14-30-22(20(19)23(27)28)25-21(26)16-6-10-17(11-7-16)24(2,3)4/h6-14H,5H2,1-4H3,(H,25,26)(H,27,28)
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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM50436105
PNG
(CHEMBL2397253 | US10273214, Example 1180-20)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)cc(OC)c23)C(=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1/C26H26ClNO5/c1-30-20-7-9-21(10-8-20)33-16-23-25-17(14-22(31-2)15-24(25)32-3)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3
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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM381963
PNG
(US10273214, Example 1434)
Show SMILES Cc1ccc(cc1)-c1csc(NC(=O)c2ccc(cc2)C(C)(C)C)c1C(O)=O
Show InChI InChI=1S/C23H23NO3S/c1-14-5-7-15(8-6-14)18-13-28-21(19(18)22(26)27)24-20(25)16-9-11-17(12-10-16)23(2,3)4/h5-13H,1-4H3,(H,24,25)(H,26,27)
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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM53433
PNG
(2-[(4-tert-butylbenzoyl)amino]-4-(4-methoxyphenyl)...)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)c2ccc(cc2)C(C)(C)C)c1C(O)=O
Show InChI InChI=1S/C23H23NO4S/c1-23(2,3)16-9-5-15(6-10-16)20(25)24-21-19(22(26)27)18(13-29-21)14-7-11-17(28-4)12-8-14/h5-13H,1-4H3,(H,24,25)(H,26,27)
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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM381958
PNG
(US10273214, Example 1482)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)NC1=C(C2CCCCCC2S1)C(O)=O
Show InChI InChI=1S/C21H27NO3S/c1-21(2,3)14-11-9-13(10-12-14)18(23)22-19-17(20(24)25)15-7-5-4-6-8-16(15)26-19/h9-12,15-16H,4-8H2,1-3H3,(H,22,23)(H,24,25)
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Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM381957
PNG
(US10273214, Example 1417)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)Nc1sc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C20H23NO3S/c1-20(2,3)13-10-8-12(9-11-13)17(22)21-18-16(19(23)24)14-6-4-5-7-15(14)25-18/h8-11H,4-7H2,1-3H3,(H,21,22)(H,23,24)
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Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM381959
PNG
(US10273214, Example 1481)
Show SMILES CC1CCc2c(C1)sc(NC(=O)c1ccc(cc1)C(C)(C)C)c2C(O)=O
Show InChI InChI=1S/C21H25NO3S/c1-12-5-10-15-16(11-12)26-19(17(15)20(24)25)22-18(23)13-6-8-14(9-7-13)21(2,3)4/h6-9,12H,5,10-11H2,1-4H3,(H,22,23)(H,24,25)
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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM381968
PNG
(US10273214, Example 1563)
Show SMILES CC(C)(C)c1ccc(CSc2nc(N)cc(O)n2)cc1
Show InChI InChI=1S/C15H19N3OS/c1-15(2,3)11-6-4-10(5-7-11)9-20-14-17-12(16)8-13(19)18-14/h4-8H,9H2,1-3H3,(H3,16,17,18,19)
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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM381961
PNG
(US10273214, Example 1423)
Show SMILES CCOc1ccc(cc1)-c1csc(NC(=O)c2ccc(cc2)C(C)(C)C)c1C(O)=O
Show InChI InChI=1S/C24H25NO4S/c1-5-29-18-12-8-15(9-13-18)19-14-30-22(20(19)23(27)28)25-21(26)16-6-10-17(11-7-16)24(2,3)4/h6-14H,5H2,1-4H3,(H,25,26)(H,27,28)
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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM81081
PNG
(2-[(4-tert-butylbenzoyl)amino]-5,6-dihydro-4H-cycl...)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)Nc1sc2CCCc2c1C(O)=O
Show InChI InChI=1S/C19H21NO3S/c1-19(2,3)12-9-7-11(8-10-12)16(21)20-17-15(18(22)23)13-5-4-6-14(13)24-17/h7-10H,4-6H2,1-3H3,(H,20,21)(H,22,23)
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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM381961
PNG
(US10273214, Example 1423)
Show SMILES CCOc1ccc(cc1)-c1csc(NC(=O)c2ccc(cc2)C(C)(C)C)c1C(O)=O
Show InChI InChI=1S/C24H25NO4S/c1-5-29-18-12-8-15(9-13-18)19-14-30-22(20(19)23(27)28)25-21(26)16-6-10-17(11-7-16)24(2,3)4/h6-14H,5H2,1-4H3,(H,25,26)(H,27,28)
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Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM50436074
PNG
(CHEMBL2397209 | US10273214, Example 1180-11)
Show SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(I)c2)cc1
Show InChI InChI=1/C26H26INO5/c1-30-20-7-9-21(10-8-20)33-16-23-22-15-25(32-3)24(31-2)14-17(22)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3
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Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM381954
PNG
(US10273214, Example 1418)
Show SMILES Cc1sc(NC(=O)c2ccc(cc2)C(C)(C)C)c(C(O)=O)c1C
Show InChI InChI=1S/C18H21NO3S/c1-10-11(2)23-16(14(10)17(21)22)19-15(20)12-6-8-13(9-7-12)18(3,4)5/h6-9H,1-5H3,(H,19,20)(H,21,22)
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Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM381965
PNG
(US10273214, Example 1433)
Show SMILES Cc1sc(NC(=O)c2ccc(cc2)C(C)(C)C)c(C(N)=O)c1C
Show InChI InChI=1S/C18H22N2O2S/c1-10-11(2)23-17(14(10)15(19)21)20-16(22)12-6-8-13(9-7-12)18(3,4)5/h6-9H,1-5H3,(H2,19,21)(H,20,22)
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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM381955
PNG
(US10273214, Example 1421)
Show SMILES CCc1cc(C(O)=O)c(NC(=O)c2ccc(cc2)C(C)(C)C)s1
Show InChI InChI=1S/C18H21NO3S/c1-5-13-10-14(17(21)22)16(23-13)19-15(20)11-6-8-12(9-7-11)18(2,3)4/h6-10H,5H2,1-4H3,(H,19,20)(H,21,22)
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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM381954
PNG
(US10273214, Example 1418)
Show SMILES Cc1sc(NC(=O)c2ccc(cc2)C(C)(C)C)c(C(O)=O)c1C
Show InChI InChI=1S/C18H21NO3S/c1-10-11(2)23-16(14(10)17(21)22)19-15(20)12-6-8-13(9-7-12)18(3,4)5/h6-9H,1-5H3,(H,19,20)(H,21,22)
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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM381960
PNG
(US10273214, Example 1406)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)Nc1scc(c1C(O)=O)-c1ccccc1
Show InChI InChI=1S/C22H21NO3S/c1-22(2,3)16-11-9-15(10-12-16)19(24)23-20-18(21(25)26)17(13-27-20)14-7-5-4-6-8-14/h4-13H,1-3H3,(H,23,24)(H,25,26)
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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM381968
PNG
(US10273214, Example 1563)
Show SMILES CC(C)(C)c1ccc(CSc2nc(N)cc(O)n2)cc1
Show InChI InChI=1S/C15H19N3OS/c1-15(2,3)11-6-4-10(5-7-11)9-20-14-17-12(16)8-13(19)18-14/h4-8H,9H2,1-3H3,(H3,16,17,18,19)
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Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM381955
PNG
(US10273214, Example 1421)
Show SMILES CCc1cc(C(O)=O)c(NC(=O)c2ccc(cc2)C(C)(C)C)s1
Show InChI InChI=1S/C18H21NO3S/c1-5-13-10-14(17(21)22)16(23-13)19-15(20)11-6-8-12(9-7-11)18(2,3)4/h6-10H,5H2,1-4H3,(H,19,20)(H,21,22)
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Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM53433
PNG
(2-[(4-tert-butylbenzoyl)amino]-4-(4-methoxyphenyl)...)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)c2ccc(cc2)C(C)(C)C)c1C(O)=O
Show InChI InChI=1S/C23H23NO4S/c1-23(2,3)16-9-5-15(6-10-16)20(25)24-21-19(22(26)27)18(13-29-21)14-7-11-17(28-4)12-8-14/h5-13H,1-4H3,(H,24,25)(H,26,27)
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Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM53433
PNG
(2-[(4-tert-butylbenzoyl)amino]-4-(4-methoxyphenyl)...)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)c2ccc(cc2)C(C)(C)C)c1C(O)=O
Show InChI InChI=1S/C23H23NO4S/c1-23(2,3)16-9-5-15(6-10-16)20(25)24-21-19(22(26)27)18(13-29-21)14-7-11-17(28-4)12-8-14/h5-13H,1-4H3,(H,24,25)(H,26,27)
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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM381964
PNG
(US10273214, Example 1441)
Show SMILES OC(=O)c1c(NC(=O)c2cccc3ccccc23)sc2CCCc12
Show InChI InChI=1S/C19H15NO3S/c21-17(13-8-3-6-11-5-1-2-7-12(11)13)20-18-16(19(22)23)14-9-4-10-15(14)24-18/h1-3,5-8H,4,9-10H2,(H,20,21)(H,22,23)
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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM381960
PNG
(US10273214, Example 1406)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)Nc1scc(c1C(O)=O)-c1ccccc1
Show InChI InChI=1S/C22H21NO3S/c1-22(2,3)16-11-9-15(10-12-16)19(24)23-20-18(21(25)26)17(13-27-20)14-7-5-4-6-8-14/h4-13H,1-3H3,(H,23,24)(H,25,26)
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n/an/a 4.40E+4n/an/an/an/an/an/a



Emory University

US Patent




US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM381960
PNG
(US10273214, Example 1406)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)Nc1scc(c1C(O)=O)-c1ccccc1
Show InChI InChI=1S/C22H21NO3S/c1-22(2,3)16-11-9-15(10-12-16)19(24)23-20-18(21(25)26)17(13-27-20)14-7-5-4-6-8-14/h4-13H,1-3H3,(H,23,24)(H,25,26)
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n/an/a 4.50E+4n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM381965
PNG
(US10273214, Example 1433)
Show SMILES Cc1sc(NC(=O)c2ccc(cc2)C(C)(C)C)c(C(N)=O)c1C
Show InChI InChI=1S/C18H22N2O2S/c1-10-11(2)23-17(14(10)15(19)21)20-16(22)12-6-8-13(9-7-12)18(3,4)5/h6-9H,1-5H3,(H2,19,21)(H,20,22)
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n/an/a 5.10E+4n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM381968
PNG
(US10273214, Example 1563)
Show SMILES CC(C)(C)c1ccc(CSc2nc(N)cc(O)n2)cc1
Show InChI InChI=1S/C15H19N3OS/c1-15(2,3)11-6-4-10(5-7-11)9-20-14-17-12(16)8-13(19)18-14/h4-8H,9H2,1-3H3,(H3,16,17,18,19)
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n/an/a 6.80E+4n/an/an/an/an/an/a



Emory University

US Patent




US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM81081
PNG
(2-[(4-tert-butylbenzoyl)amino]-5,6-dihydro-4H-cycl...)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)Nc1sc2CCCc2c1C(O)=O
Show InChI InChI=1S/C19H21NO3S/c1-19(2,3)12-9-7-11(8-10-12)16(21)20-17-15(18(22)23)13-5-4-6-14(13)24-17/h7-10H,4-6H2,1-3H3,(H,20,21)(H,22,23)
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PC sid
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US Patent
n/an/a 7.70E+4n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM381953
PNG
(US10273214, Example 1357)
Show SMILES Cc1cc(C(O)=O)c(NC(=O)c2ccc(cc2)C(C)(C)C)s1
Show InChI InChI=1S/C17H19NO3S/c1-10-9-13(16(20)21)15(22-10)18-14(19)11-5-7-12(8-6-11)17(2,3)4/h5-9H,1-4H3,(H,18,19)(H,20,21)
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n/an/a 1.20E+5n/an/an/an/an/an/a



Emory University

US Patent




US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM381966
PNG
(US10273214, Example 1343)
Show SMILES CSC1=NCCN1C(=O)c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C15H20N2OS/c1-15(2,3)12-7-5-11(6-8-12)13(18)17-10-9-16-14(17)19-4/h5-8H,9-10H2,1-4H3
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n/an/a 1.38E+5n/an/an/an/an/an/a



Emory University

US Patent




US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM381966
PNG
(US10273214, Example 1343)
Show SMILES CSC1=NCCN1C(=O)c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C15H20N2OS/c1-15(2,3)12-7-5-11(6-8-12)13(18)17-10-9-16-14(17)19-4/h5-8H,9-10H2,1-4H3
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n/an/a 1.39E+5n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM381967
PNG
(US10273214, Example 1344)
Show SMILES CSC1=NCCN1C(=O)c1ccc(C)cc1
Show InChI InChI=1S/C12H14N2OS/c1-9-3-5-10(6-4-9)11(15)14-8-7-13-12(14)16-2/h3-6H,7-8H2,1-2H3
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n/an/a 1.74E+5n/an/an/an/an/an/a



Emory University

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US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2C


(Homo sapiens (Human))
BDBM381953
PNG
(US10273214, Example 1357)
Show SMILES Cc1cc(C(O)=O)c(NC(=O)c2ccc(cc2)C(C)(C)C)s1
Show InChI InChI=1S/C17H19NO3S/c1-10-9-13(16(20)21)15(22-10)18-14(19)11-5-7-12(8-6-11)17(2,3)4/h5-9H,1-4H3,(H,18,19)(H,20,21)
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n/an/a 1.75E+5n/an/an/an/an/an/a



Emory University

US Patent


Assay Description
The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...


US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(Homo sapiens (Human))
BDBM381966
PNG
(US10273214, Example 1343)
Show SMILES CSC1=NCCN1C(=O)c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C15H20N2OS/c1-15(2,3)12-7-5-11(6-8-12)13(18)17-10-9-16-14(17)19-4/h5-8H,9-10H2,1-4H3
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n/an/a 2.10E+5n/an/an/an/an/an/a



Emory University

US Patent




US Patent US10273214 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%