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Patent code US10273223

Compile Data Set for Download or QSAR

Found 391 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM382444
PNG
(US10273223, Compound D-51)
Show SMILES CNCCN1CCC(CC1)c1cc(C(=O)NCC2=C(C)C=C(C)NC2C)c2cnn(C3CCCC3)c2c1
Show InChI InChI=1S/C30H44N6O/c1-20-15-21(2)34-22(3)27(20)18-32-30(37)26-16-24(23-9-12-35(13-10-23)14-11-31-4)17-29-28(26)19-33-36(29)25-7-5-6-8-25/h15-17,19,22-23,25,31,34H,5-14,18H2,1-4H3,(H,32,37)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM325817
PNG
(US10273223, Compound A-13 | US9637472, Compound A-...)
Show SMILES CC(C)n1ncc2c(cc(nc12)-c1cccc(c1)C(=O)NCCCN(C)C)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C30H37N7O3/c1-18(2)37-27-25(17-33-37)23(29(39)32-16-24-19(3)13-20(4)34-30(24)40)15-26(35-27)21-9-7-10-22(14-21)28(38)31-11-8-12-36(5)6/h7,9-10,13-15,17-18H,8,11-12,16H2,1-6H3,(H,31,38)(H,32,39)(H,34,40)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326069
PNG
(US10273223, Compound C-2 | US9637472, Compound C-2)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)-c2ccc(CN3CCOCC3)nc2)c(=O)[nH]1
Show InChI InChI=1S/C31H36N6O3/c1-20-13-21(2)35-31(39)27(20)17-33-30(38)26-14-23(15-29-28(26)18-34-37(29)25-5-3-4-6-25)22-7-8-24(32-16-22)19-36-9-11-40-12-10-36/h7-8,13-16,18,25H,3-6,9-12,17,19H2,1-2H3,(H,33,38)(H,35,39)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326071
PNG
(US10273223, Compound C-4 | US9637472, Compound C-4)
Show SMILES CN(C)CCCOCc1ccc(cc1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C3CCCC3)c2c1
Show InChI InChI=1S/C33H41N5O3/c1-22-16-23(2)36-33(40)29(22)19-34-32(39)28-17-26(18-31-30(28)20-35-38(31)27-8-5-6-9-27)25-12-10-24(11-13-25)21-41-15-7-14-37(3)4/h10-13,16-18,20,27H,5-9,14-15,19,21H2,1-4H3,(H,34,39)(H,36,40)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326076
PNG
(US10273223, Compound C-9 | US9637472, Compound C-9)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)-c2cccc(CNCCO)c2)c(=O)[nH]1
Show InChI InChI=1S/C30H35N5O3/c1-19-12-20(2)34-30(38)26(19)17-32-29(37)25-14-23(22-7-5-6-21(13-22)16-31-10-11-36)15-28-27(25)18-33-35(28)24-8-3-4-9-24/h5-7,12-15,18,24,31,36H,3-4,8-11,16-17H2,1-2H3,(H,32,37)(H,34,38)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM382371
PNG
(US10273223, Compound C-13)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)-c2ccc(CN3CCC[C@@H]3C(N)=O)cc2)c(=O)[nH]1
Show InChI InChI=1/C33H38N6O3/c1-20-14-21(2)37-33(42)27(20)17-35-32(41)26-15-24(16-30-28(26)18-36-39(30)25-6-3-4-7-25)23-11-9-22(10-12-23)19-38-13-5-8-29(38)31(34)40/h9-12,14-16,18,25,29H,3-8,13,17,19H2,1-2H3,(H2,34,40)(H,35,41)(H,37,42)/t29-/s2
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326087
PNG
(US10273223, Compound C-20 | US9637472, Compound C-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)-c2ccc(COCCN3CCOCC3)cc2)c(=O)[nH]1
Show InChI InChI=1S/C34H41N5O4/c1-23-17-24(2)37-34(41)30(23)20-35-33(40)29-18-27(19-32-31(29)21-36-39(32)28-5-3-4-6-28)26-9-7-25(8-10-26)22-43-16-13-38-11-14-42-15-12-38/h7-10,17-19,21,28H,3-6,11-16,20,22H2,1-2H3,(H,35,40)(H,37,41)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326120
PNG
(US10273223, Compound D-18 | US9637472, Compound D-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)N2CCN(CC2)C(=O)C2CCNCC2)c(=O)[nH]1
Show InChI InChI=1S/C31H41N7O3/c1-20-15-21(2)35-30(40)26(20)18-33-29(39)25-16-24(17-28-27(25)19-34-38(28)23-5-3-4-6-23)36-11-13-37(14-12-36)31(41)22-7-9-32-10-8-22/h15-17,19,22-23,32H,3-14,18H2,1-2H3,(H,33,39)(H,35,40)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326140
PNG
(US10273223, Compound D-38 | US9637472, Compound D-...)
Show SMILES CN(C)CC(=O)N1CCC(=CC1)c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C3CCCC3)c2c1
Show InChI InChI=1S/C30H38N6O3/c1-19-13-20(2)33-30(39)25(19)16-31-29(38)24-14-22(21-9-11-35(12-10-21)28(37)18-34(3)4)15-27-26(24)17-32-36(27)23-7-5-6-8-23/h9,13-15,17,23H,5-8,10-12,16,18H2,1-4H3,(H,31,38)(H,33,39)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326146
PNG
(US10273223, Compound D-44 | US9637472, Compound D-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)C2=CCN(CC2)C2CCNCC2)c(=O)[nH]1
Show InChI InChI=1S/C31H40N6O2/c1-20-15-21(2)35-31(39)27(20)18-33-30(38)26-16-23(17-29-28(26)19-34-37(29)25-5-3-4-6-25)22-9-13-36(14-10-22)24-7-11-32-12-8-24/h9,15-17,19,24-25,32H,3-8,10-14,18H2,1-2H3,(H,33,38)(H,35,39)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326147
PNG
(US10273223, Compound D-45 | US9637472, Compound D-...)
Show SMILES CNCC(=O)N1CCC(=CC1)c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C3CCCC3)c2c1
Show InChI InChI=1S/C29H36N6O3/c1-18-12-19(2)33-29(38)24(18)15-31-28(37)23-13-21(20-8-10-34(11-9-20)27(36)17-30-3)14-26-25(23)16-32-35(26)22-6-4-5-7-22/h8,12-14,16,22,30H,4-7,9-11,15,17H2,1-3H3,(H,31,37)(H,33,38)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326154
PNG
(US10273223, Compound D-52 | US9637472, Compound D-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(Br)cc3n(ncc23)C2CCN(CC2)C(=O)C2CCNCC2)c(=O)[nH]1
Show InChI InChI=1S/C27H33BrN6O3/c1-16-11-17(2)32-26(36)22(16)14-30-25(35)21-12-19(28)13-24-23(21)15-31-34(24)20-5-9-33(10-6-20)27(37)18-3-7-29-8-4-18/h11-13,15,18,20,29H,3-10,14H2,1-2H3,(H,30,35)(H,32,36)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50149602
PNG
(CHEMBL3770239 | US10273223, Compound A-10 | US9637...)
Show SMILES CC(C)n1ncc2c(cc(nc12)-c1ccc(nc1)N1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C27H32N8O2/c1-16(2)35-25-22(15-31-35)20(26(36)30-14-21-17(3)11-18(4)32-27(21)37)12-23(33-25)19-5-6-24(29-13-19)34-9-7-28-8-10-34/h5-6,11-13,15-16,28H,7-10,14H2,1-4H3,(H,30,36)(H,32,37)
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n/an/a<300n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326197
PNG
(US10273223, Compound D-96 | US9637472, Compound D-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)C2CCN(CCN)CC2)c(=O)[nH]1
Show InChI InChI=1S/C28H38N6O2/c1-18-13-19(2)32-28(36)24(18)16-30-27(35)23-14-21(20-7-10-33(11-8-20)12-9-29)15-26-25(23)17-31-34(26)22-5-3-4-6-22/h13-15,17,20,22H,3-12,16,29H2,1-2H3,(H,30,35)(H,32,36)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM325914
PNG
(US10273223, Compound B-8 | US9637472, Compound B-8)
Show SMILES CC(C)n1ncc2c(cc(nc12)C1CCN(CC1)C(=O)C1CN(C)C1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C28H37N7O3/c1-16(2)35-25-23(13-30-35)21(26(36)29-12-22-17(3)10-18(4)31-27(22)37)11-24(32-25)19-6-8-34(9-7-19)28(38)20-14-33(5)15-20/h10-11,13,16,19-20H,6-9,12,14-15H2,1-5H3,(H,29,36)(H,31,37)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM325940
PNG
(US10273223, Compound B-34 | US9637472, Compound B-...)
Show SMILES CC(C)n1ncc2c(cc(nc12)C1=CCN(CC1)C(=O)C1CCN(C)CC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C30H39N7O3/c1-18(2)37-27-25(17-32-37)23(28(38)31-16-24-19(3)14-20(4)33-29(24)39)15-26(34-27)21-8-12-36(13-9-21)30(40)22-6-10-35(5)11-7-22/h8,14-15,17-18,22H,6-7,9-13,16H2,1-5H3,(H,31,38)(H,33,39)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326078
PNG
(US10273223, Compound C-11 | US9637472, Compound C-...)
Show SMILES CN(C)CCCOc1cccc(c1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C3CCCC3)c2c1
Show InChI InChI=1S/C32H39N5O3/c1-21-15-22(2)35-32(39)28(21)19-33-31(38)27-17-24(18-30-29(27)20-34-37(30)25-10-5-6-11-25)23-9-7-12-26(16-23)40-14-8-13-36(3)4/h7,9,12,15-18,20,25H,5-6,8,10-11,13-14,19H2,1-4H3,(H,33,38)(H,35,39)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326086
PNG
(US10273223, Compound C-19 | US9637472, Compound C-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)-c2cccc(C[N+](C)(C)CCO)c2)c(=O)[nH]1
Show InChI InChI=1S/C32H39N5O3/c1-21-14-22(2)35-32(40)28(21)18-33-31(39)27-16-25(17-30-29(27)19-34-36(30)26-10-5-6-11-26)24-9-7-8-23(15-24)20-37(3,4)12-13-38/h7-9,14-17,19,26,38H,5-6,10-13,18,20H2,1-4H3,(H-,33,35,39,40)/p+1
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326088
PNG
(US10273223, Compound C-21 | US9637472, Compound C-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)-c2cccnc2)c(=O)[nH]1
Show InChI InChI=1S/C26H27N5O2/c1-16-10-17(2)30-26(33)22(16)14-28-25(32)21-11-19(18-6-5-9-27-13-18)12-24-23(21)15-29-31(24)20-7-3-4-8-20/h5-6,9-13,15,20H,3-4,7-8,14H2,1-2H3,(H,28,32)(H,30,33)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326099
PNG
(US10273223, Compound C-32 | US9637472, Compound C-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)-c2ccc(CN3CCOCC3)cc2Cl)c(=O)[nH]1
Show InChI InChI=1S/C32H36ClN5O3/c1-20-13-21(2)36-32(40)27(20)17-34-31(39)26-15-23(16-30-28(26)18-35-38(30)24-5-3-4-6-24)25-8-7-22(14-29(25)33)19-37-9-11-41-12-10-37/h7-8,13-16,18,24H,3-6,9-12,17,19H2,1-2H3,(H,34,39)(H,36,40)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326104
PNG
(US10273223, Compound D-2 | US9637472, Compound D-2)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)C2=CC(C)(C)NC(C)(C)C2)c(=O)[nH]1
Show InChI InChI=1S/C30H39N5O2/c1-18-11-19(2)33-28(37)24(18)16-31-27(36)23-12-20(21-14-29(3,4)34-30(5,6)15-21)13-26-25(23)17-32-35(26)22-9-7-8-10-22/h11-14,17,22,34H,7-10,15-16H2,1-6H3,(H,31,36)(H,33,37)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326116
PNG
(US10273223, Compound D-14 | US9637472, Compound D-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(Br)cc3n(ncc23)C2CCN(CC2)C(=O)C2CNC2)c(=O)[nH]1
Show InChI InChI=1S/C25H29BrN6O3/c1-14-7-15(2)30-24(34)20(14)12-28-23(33)19-8-17(26)9-22-21(19)13-29-32(22)18-3-5-31(6-4-18)25(35)16-10-27-11-16/h7-9,13,16,18,27H,3-6,10-12H2,1-2H3,(H,28,33)(H,30,34)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM325822
PNG
(US10273223, Compound A-18 | US9637472, Compound A-...)
Show SMILES CC(C)n1ncc2c(cc(nc12)-c1ccc(cc1)C(=O)NCCN(C)C)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C29H35N7O3/c1-17(2)36-26-24(16-32-36)22(28(38)31-15-23-18(3)13-19(4)33-29(23)39)14-25(34-26)20-7-9-21(10-8-20)27(37)30-11-12-35(5)6/h7-10,13-14,16-17H,11-12,15H2,1-6H3,(H,30,37)(H,31,38)(H,33,39)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326079
PNG
(US10273223, Compound C-12 | US9637472, Compound C-...)
Show SMILES CNCCCOc1ccc(cc1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C3CCCC3)c2c1
Show InChI InChI=1S/C31H37N5O3/c1-20-15-21(2)35-31(38)27(20)18-33-30(37)26-16-23(22-9-11-25(12-10-22)39-14-6-13-32-3)17-29-28(26)19-34-36(29)24-7-4-5-8-24/h9-12,15-17,19,24,32H,4-8,13-14,18H2,1-3H3,(H,33,37)(H,35,38)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326096
PNG
(US10273223, Compound C-29 | US9637472, Compound C-...)
Show SMILES CN(CCO)Cc1cccc(c1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C3CCCC3)c2c1
Show InChI InChI=1S/C31H37N5O3/c1-20-13-21(2)34-31(39)27(20)17-32-30(38)26-15-24(23-8-6-7-22(14-23)19-35(3)11-12-37)16-29-28(26)18-33-36(29)25-9-4-5-10-25/h6-8,13-16,18,25,37H,4-5,9-12,17,19H2,1-3H3,(H,32,38)(H,34,39)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326119
PNG
(US10273223, Compound D-17 | US9637472, Compound D-...)
Show SMILES CN(C)Cc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(Br)cc2n(ncc12)C1CCCC1
Show InChI InChI=1S/C23H28BrN5O2/c1-14-8-15(13-28(2)3)19(23(31)27-14)11-25-22(30)18-9-16(24)10-21-20(18)12-26-29(21)17-6-4-5-7-17/h8-10,12,17H,4-7,11,13H2,1-3H3,(H,25,30)(H,27,31)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326127
PNG
(US10273223, Compound D-25 | US9637472, Compound D-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCN(CC2)C(=O)C(C)(C)C)C2=CC(C)(C)NC(C)(C)C2)c(=O)[nH]1
Show InChI InChI=1S/C35H48N6O3/c1-21-14-22(2)38-31(43)27(21)19-36-30(42)26-15-23(24-17-34(6,7)39-35(8,9)18-24)16-29-28(26)20-37-41(29)25-10-12-40(13-11-25)32(44)33(3,4)5/h14-17,20,25,39H,10-13,18-19H2,1-9H3,(H,36,42)(H,38,43)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326143
PNG
(US10273223, Compound D-41 | US9637472, Compound D-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)C2=CCNCC2)c(=O)[nH]1
Show InChI InChI=1S/C26H31N5O2/c1-16-11-17(2)30-26(33)22(16)14-28-25(32)21-12-19(18-7-9-27-10-8-18)13-24-23(21)15-29-31(24)20-5-3-4-6-20/h7,11-13,15,20,27H,3-6,8-10,14H2,1-2H3,(H,28,32)(H,30,33)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326144
PNG
(US10273223, Compound D-42 | US9637472, Compound D-...)
Show SMILES CC(C)C(=O)N1CCC(CC1)n1ncc2c(cc(Br)cc12)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C25H30BrN5O3/c1-14(2)25(34)30-7-5-18(6-8-30)31-22-11-17(26)10-19(21(22)13-28-31)23(32)27-12-20-15(3)9-16(4)29-24(20)33/h9-11,13-14,18H,5-8,12H2,1-4H3,(H,27,32)(H,29,33)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM325926
PNG
(US10273223, Compound B-20 | US9637472, Compound B-...)
Show SMILES CC(C)n1ncc2c(cc(nc12)C1=CCN(CC1)C(=O)C1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C29H37N7O3/c1-17(2)36-26-24(16-32-36)22(27(37)31-15-23-18(3)13-19(4)33-28(23)38)14-25(34-26)20-7-11-35(12-8-20)29(39)21-5-9-30-10-6-21/h7,13-14,16-17,21,30H,5-6,8-12,15H2,1-4H3,(H,31,37)(H,33,38)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM325934
PNG
(US10273223, Compound B-28 | US9637472, Compound B-...)
Show SMILES CC(C)n1ncc2c(cc(nc12)C1=CCN(CC1)C(=O)C1CCCNC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1/C29H37N7O3/c1-17(2)36-26-24(16-32-36)22(27(37)31-15-23-18(3)12-19(4)33-28(23)38)13-25(34-26)20-7-10-35(11-8-20)29(39)21-6-5-9-30-14-21/h7,12-13,16-17,21,30H,5-6,8-11,14-15H2,1-4H3,(H,31,37)(H,33,38)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326077
PNG
(US10273223, Compound C-10 | US9637472, Compound C-...)
Show SMILES CNCCCOc1cccc(c1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C3CCCC3)c2c1
Show InChI InChI=1S/C31H37N5O3/c1-20-14-21(2)35-31(38)27(20)18-33-30(37)26-16-23(22-8-6-11-25(15-22)39-13-7-12-32-3)17-29-28(26)19-34-36(29)24-9-4-5-10-24/h6,8,11,14-17,19,24,32H,4-5,7,9-10,12-13,18H2,1-3H3,(H,33,37)(H,35,38)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326102
PNG
(US10273223, Compound C-35 | US9637472, Compound C-...)
Show SMILES CN(C)CCCOc1ccc(cc1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C3CCCC3)c2c1
Show InChI InChI=1S/C32H39N5O3/c1-21-16-22(2)35-32(39)28(21)19-33-31(38)27-17-24(18-30-29(27)20-34-37(30)25-8-5-6-9-25)23-10-12-26(13-11-23)40-15-7-14-36(3)4/h10-13,16-18,20,25H,5-9,14-15,19H2,1-4H3,(H,33,38)(H,35,39)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326118
PNG
(US10273223, Compound D-16 | US9637472, Compound D-...)
Show SMILES CN1CCC(CC1)N1CCC(CC1)n1ncc2c(cc(Br)cc12)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C27H35BrN6O2/c1-17-12-18(2)31-27(36)23(17)15-29-26(35)22-13-19(28)14-25-24(22)16-30-34(25)21-6-10-33(11-7-21)20-4-8-32(3)9-5-20/h12-14,16,20-21H,4-11,15H2,1-3H3,(H,29,35)(H,31,36)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM325821
PNG
(US10273223, Compound A-17 | US9637472, Compound A-...)
Show SMILES CC(C)n1nc(Br)c2c(cc(nc12)-c1ccc(CN2CCOCC2)cc1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C29H33BrN6O3/c1-17(2)36-27-25(26(30)34-36)22(28(37)31-15-23-18(3)13-19(4)32-29(23)38)14-24(33-27)21-7-5-20(6-8-21)16-35-9-11-39-12-10-35/h5-8,13-14,17H,9-12,15-16H2,1-4H3,(H,31,37)(H,32,38)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM382207
PNG
(US10273223, Compound B-4)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(nc3n(ncc23)C2CCCC2)C2CC(C)(C)NC(C)(C)C2)c(=O)[nH]1
Show InChI InChI=1S/C29H40N6O2/c1-17-11-18(2)32-27(37)22(17)15-30-26(36)21-12-24(19-13-28(3,4)34-29(5,6)14-19)33-25-23(21)16-31-35(25)20-9-7-8-10-20/h11-12,16,19-20,34H,7-10,13-15H2,1-6H3,(H,30,36)(H,32,37)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM325931
PNG
(US10273223, Compound B-25 | US9637472, Compound B-...)
Show SMILES CCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(nc2n(ncc12)C(C)C)C1=CC(C)(C)NC(C)(C)C1
Show InChI InChI=1S/C28H38N6O2/c1-9-18-10-17(4)31-26(36)21(18)14-29-25(35)20-11-23(19-12-27(5,6)33-28(7,8)13-19)32-24-22(20)15-30-34(24)16(2)3/h10-12,15-16,33H,9,13-14H2,1-8H3,(H,29,35)(H,31,36)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM325936
PNG
(US10273223, Compound B-30 | US9637472, Compound B-...)
Show SMILES CC(C)n1ncc2c(cc(nc12)C1=CCN(CC1)C(=O)C1CNC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C27H33N7O3/c1-15(2)34-24-22(14-30-34)20(25(35)29-13-21-16(3)9-17(4)31-26(21)36)10-23(32-24)18-5-7-33(8-6-18)27(37)19-11-28-12-19/h5,9-10,14-15,19,28H,6-8,11-13H2,1-4H3,(H,29,35)(H,31,36)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM325939
PNG
(US10273223, Compound B-33 | US9637472, Compound B-...)
Show SMILES CC(C)n1ncc2c(cc(nc12)C1=CCN(CC1)C1CCN(CCS(C)(=O)=O)CC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C31H43N7O4S/c1-20(2)38-29-27(19-33-38)25(30(39)32-18-26-21(3)16-22(4)34-31(26)40)17-28(35-29)23-6-12-37(13-7-23)24-8-10-36(11-9-24)14-15-43(5,41)42/h6,16-17,19-20,24H,7-15,18H2,1-5H3,(H,32,39)(H,34,40)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50075051
PNG
(CHEMBL3360855 | EPZ005687 | US10273223, Compound C...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)-c2ccc(CN3CCOCC3)cc2)c(=O)[nH]1
Show InChI InChI=1S/C32H37N5O3/c1-21-15-22(2)35-32(39)28(21)18-33-31(38)27-16-25(17-30-29(27)19-34-37(30)26-5-3-4-6-26)24-9-7-23(8-10-24)20-36-11-13-40-14-12-36/h7-10,15-17,19,26H,3-6,11-14,18,20H2,1-2H3,(H,33,38)(H,35,39)
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n/an/a<300n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326070
PNG
(US10273223, Compound C-3 | US9637472, Compound C-3)
Show SMILES CN(C)Cc1ccc(cc1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C3CCCC3)c2c1
Show InChI InChI=1S/C30H35N5O2/c1-19-13-20(2)33-30(37)26(19)16-31-29(36)25-14-23(22-11-9-21(10-12-22)18-34(3)4)15-28-27(25)17-32-35(28)24-7-5-6-8-24/h9-15,17,24H,5-8,16,18H2,1-4H3,(H,31,36)(H,33,37)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326081
PNG
(US10273223, Compound C-14 | US9637472, Compound C-...)
Show SMILES CCOc1ccc(cc1-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2cnn(C3CCCC3)c2c1)S(=O)(=O)N1CCN(CC)CC1
Show InChI InChI=1S/C35H44N6O5S/c1-5-39-13-15-40(16-14-39)47(44,45)27-11-12-33(46-6-2)28(20-27)25-18-29(31-22-37-41(32(31)19-25)26-9-7-8-10-26)34(42)36-21-30-23(3)17-24(4)38-35(30)43/h11-12,17-20,22,26H,5-10,13-16,21H2,1-4H3,(H,36,42)(H,38,43)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326082
PNG
(US10273223, Compound C-15 | US9637472, Compound C-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)-c2ccc(CN3CCOCC3)cn2)c(=O)[nH]1
Show InChI InChI=1S/C31H36N6O3/c1-20-13-21(2)35-31(39)26(20)17-33-30(38)25-14-23(15-29-27(25)18-34-37(29)24-5-3-4-6-24)28-8-7-22(16-32-28)19-36-9-11-40-12-10-36/h7-8,13-16,18,24H,3-6,9-12,17,19H2,1-2H3,(H,33,38)(H,35,39)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326085
PNG
(US10273223, Compound C-18 | US9637472, Compound C-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)-c2ccc(COCCCN3CCOCC3)cc2)c(=O)[nH]1
Show InChI InChI=1S/C35H43N5O4/c1-24-18-25(2)38-35(42)31(24)21-36-34(41)30-19-28(20-33-32(30)22-37-40(33)29-6-3-4-7-29)27-10-8-26(9-11-27)23-44-15-5-12-39-13-16-43-17-14-39/h8-11,18-20,22,29H,3-7,12-17,21,23H2,1-2H3,(H,36,41)(H,38,42)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326090
PNG
(US10273223, Compound C-23 | US9637472, Compound C-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)-c2cccc(COCCN)c2)c(=O)[nH]1
Show InChI InChI=1S/C30H35N5O3/c1-19-12-20(2)34-30(37)26(19)16-32-29(36)25-14-23(22-7-5-6-21(13-22)18-38-11-10-31)15-28-27(25)17-33-35(28)24-8-3-4-9-24/h5-7,12-15,17,24H,3-4,8-11,16,18,31H2,1-2H3,(H,32,36)(H,34,37)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326100
PNG
(US10273223, Compound C-33 | US9637472, Compound C-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)-c2cnn(CCN3CCOCC3)c2)c(=O)[nH]1
Show InChI InChI=1S/C30H37N7O3/c1-20-13-21(2)34-30(39)26(20)17-31-29(38)25-14-22(15-28-27(25)18-33-37(28)24-5-3-4-6-24)23-16-32-36(19-23)8-7-35-9-11-40-12-10-35/h13-16,18-19,24H,3-12,17H2,1-2H3,(H,31,38)(H,34,39)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326101
PNG
(US10273223, Compound C-34 | US9637472, Compound C-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCN(CC2)C(=O)C(C)(C)C)-c2cnn(CCN3CCOCC3)c2)c(=O)[nH]1
Show InChI InChI=1S/C35H46N8O4/c1-23-16-24(2)39-33(45)29(23)20-36-32(44)28-17-25(26-19-37-42(22-26)11-10-40-12-14-47-15-13-40)18-31-30(28)21-38-43(31)27-6-8-41(9-7-27)34(46)35(3,4)5/h16-19,21-22,27H,6-15,20H2,1-5H3,(H,36,44)(H,39,45)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326108
PNG
(US10273223, Compound D-6 | US9637472, Compound D-6)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)C2CCN(CC2)C2CCNCC2)c(=O)[nH]1
Show InChI InChI=1S/C31H42N6O2/c1-20-15-21(2)35-31(39)27(20)18-33-30(38)26-16-23(17-29-28(26)19-34-37(29)25-5-3-4-6-25)22-9-13-36(14-10-22)24-7-11-32-12-8-24/h15-17,19,22,24-25,32H,3-14,18H2,1-2H3,(H,33,38)(H,35,39)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326114
PNG
(US10273223, Compound D-12 | US9637472, Compound D-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(Br)cc3n(ncc23)C2CCN(CC2)C(=O)OC(C)(C)C)c(=O)[nH]1
Show InChI InChI=1S/C26H32BrN5O4/c1-15-10-16(2)30-24(34)20(15)13-28-23(33)19-11-17(27)12-22-21(19)14-29-32(22)18-6-8-31(9-7-18)25(35)36-26(3,4)5/h10-12,14,18H,6-9,13H2,1-5H3,(H,28,33)(H,30,34)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM326126
PNG
(US10273223, Compound D-24 | US9637472, Compound D-...)
Show SMILES Cc1cc(C)c(CNC(=O)c2cc(Cl)cc3n(ncc23)C2CCN(CC2)C(=O)C(C)(C)C)c(=O)[nH]1
Show InChI InChI=1S/C26H32ClN5O3/c1-15-10-16(2)30-24(34)20(15)13-28-23(33)19-11-17(27)12-22-21(19)14-29-32(22)18-6-8-31(9-7-18)25(35)26(3,4)5/h10-12,14,18H,6-9,13H2,1-5H3,(H,28,33)(H,30,34)
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Epizyme, Inc.

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%