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Patent code US10273234

Compile Data Set for Download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM382145
PNG
(1-((5-((trans-4-(tert-butyl)cyclohexyl)oxy)naphtha...)
Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)Oc1cccc2cc(CN3CCC(CC3)C(O)=O)ccc12
Show InChI InChI=1S/C27H37NO3/c1-27(2,3)22-8-10-23(11-9-22)31-25-6-4-5-21-17-19(7-12-24(21)25)18-28-15-13-20(14-16-28)26(29)30/h4-7,12,17,20,22-23H,8-11,13-16,18H2,1-3H3,(H,29,30)/t22-,23-
PDB

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n/an/a<500n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
ATX (Autotaxin) is a 125 KDa glycoprotein with lysophospholipase D (LPLD) activity that generates the bioactive lipid lysophosphatidic acid (LPA) fro...


US Patent US10273234 (2019)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM382142
PNG
(1-((5-((trans-4-(tert-butyl)cyclohexyl)oxy)naphtha...)
Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)Oc1cccc2cc(CN3CC(C3)C(O)=O)ccc12
Show InChI InChI=1S/C25H33NO3/c1-25(2,3)20-8-10-21(11-9-20)29-23-6-4-5-18-13-17(7-12-22(18)23)14-26-15-19(16-26)24(27)28/h4-7,12-13,19-21H,8-11,14-16H2,1-3H3,(H,27,28)/t20-,21-
PDB

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n/an/a<500n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
ATX (Autotaxin) is a 125 KDa glycoprotein with lysophospholipase D (LPLD) activity that generates the bioactive lipid lysophosphatidic acid (LPA) fro...


US Patent US10273234 (2019)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM382158
PNG
(9-((5-((cis-4-methylcyclohexyl)oxy)naphthalen-2-yl...)
Show SMILES C[C@H]1CC[C@H](CC1)Oc1cccc2cc(CN3C4CCCC3CC(C4)C(O)=O)ccc12
Show InChI InChI=1S/C27H35NO3/c1-18-8-11-24(12-9-18)31-26-7-2-4-20-14-19(10-13-25(20)26)17-28-22-5-3-6-23(28)16-21(15-22)27(29)30/h2,4,7,10,13-14,18,21-24H,3,5-6,8-9,11-12,15-17H2,1H3,(H,29,30)/t18-,21?,22?,23?,24+
PDB

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n/an/a 2.75E+3n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
ATX (Autotaxin) is a 125 KDa glycoprotein with lysophospholipase D (LPLD) activity that generates the bioactive lipid lysophosphatidic acid (LPA) fro...


US Patent US10273234 (2019)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM382154
PNG
(1-((5-((trans-4-ethylcyclohexyl)oxy)naphthalen-2-y...)
Show SMILES CC[C@H]1CC[C@@H](CC1)Oc1cccc2cc(CN3CCC(CC3)C(O)=O)ccc12
Show InChI InChI=1S/C25H33NO3/c1-2-18-6-9-22(10-7-18)29-24-5-3-4-21-16-19(8-11-23(21)24)17-26-14-12-20(13-15-26)25(27)28/h3-5,8,11,16,18,20,22H,2,6-7,9-10,12-15,17H2,1H3,(H,27,28)/t18-,22-
PDB

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n/an/a 2.75E+3n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
ATX (Autotaxin) is a 125 KDa glycoprotein with lysophospholipase D (LPLD) activity that generates the bioactive lipid lysophosphatidic acid (LPA) fro...


US Patent US10273234 (2019)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM382147
PNG
(3-(((5-((trans-4-(tert-butyl)cyclohexyl)oxy)naphth...)
Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)Oc1cccc2cc(CNC3CC(C(O)=O)C3(C)C)ccc12
Show InChI InChI=1S/C28H39NO3/c1-27(2,3)20-10-12-21(13-11-20)32-24-8-6-7-19-15-18(9-14-22(19)24)17-29-25-16-23(26(30)31)28(25,4)5/h6-9,14-15,20-21,23,25,29H,10-13,16-17H2,1-5H3,(H,30,31)/t20-,21-,23?,25?
PDB

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n/an/a 2.75E+3n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
ATX (Autotaxin) is a 125 KDa glycoprotein with lysophospholipase D (LPLD) activity that generates the bioactive lipid lysophosphatidic acid (LPA) fro...


US Patent US10273234 (2019)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM382151
PNG
(1-((5-((trans-4-(trifluoromethyl)cyclohexyl)oxy)na...)
Show SMILES OC(=O)C1CCN(Cc2ccc3c(O[C@H]4CC[C@@H](CC4)C(F)(F)F)cccc3c2)CC1
Show InChI InChI=1S/C24H28F3NO3/c25-24(26,27)19-5-7-20(8-6-19)31-22-3-1-2-18-14-16(4-9-21(18)22)15-28-12-10-17(11-13-28)23(29)30/h1-4,9,14,17,19-20H,5-8,10-13,15H2,(H,29,30)/t19-,20-
PDB

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n/an/a 2.75E+3n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
ATX (Autotaxin) is a 125 KDa glycoprotein with lysophospholipase D (LPLD) activity that generates the bioactive lipid lysophosphatidic acid (LPA) fro...


US Patent US10273234 (2019)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM382159
PNG
(8-((5-((cis-4-methylcyclohexyl)oxy)naphthalen-2-yl...)
Show SMILES C[C@H]1CC[C@H](CC1)Oc1cccc2cc(CN3C4CCC3CC(C4)C(O)=O)ccc12
Show InChI InChI=1S/C26H33NO3/c1-17-5-10-23(11-6-17)30-25-4-2-3-19-13-18(7-12-24(19)25)16-27-21-8-9-22(27)15-20(14-21)26(28)29/h2-4,7,12-13,17,20-23H,5-6,8-11,14-16H2,1H3,(H,28,29)/t17-,20?,21?,22?,23+
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n/an/a 2.75E+3n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
ATX (Autotaxin) is a 125 KDa glycoprotein with lysophospholipase D (LPLD) activity that generates the bioactive lipid lysophosphatidic acid (LPA) fro...


US Patent US10273234 (2019)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM382155
PNG
(1-((5-((trans-4-methylcyclohexyl)oxy)naphthalen-2-...)
Show SMILES C[C@H]1CC[C@@H](CC1)Oc1cccc2cc(CN3CCC(CC3)C(O)=O)ccc12
Show InChI InChI=1S/C24H31NO3/c1-17-5-8-21(9-6-17)28-23-4-2-3-20-15-18(7-10-22(20)23)16-25-13-11-19(12-14-25)24(26)27/h2-4,7,10,15,17,19,21H,5-6,8-9,11-14,16H2,1H3,(H,26,27)/t17-,21-
PDB

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n/an/a 2.75E+3n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
ATX (Autotaxin) is a 125 KDa glycoprotein with lysophospholipase D (LPLD) activity that generates the bioactive lipid lysophosphatidic acid (LPA) fro...


US Patent US10273234 (2019)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM382153
PNG
(1-((5-((trans-4-isopropylcyclohexyl)oxy)naphthalen...)
Show SMILES CC(C)[C@H]1CC[C@@H](CC1)Oc1cccc2cc(CN3CCC(CC3)C(O)=O)ccc12
Show InChI InChI=1S/C26H35NO3/c1-18(2)20-7-9-23(10-8-20)30-25-5-3-4-22-16-19(6-11-24(22)25)17-27-14-12-21(13-15-27)26(28)29/h3-6,11,16,18,20-21,23H,7-10,12-15,17H2,1-2H3,(H,28,29)/t20-,23-
PDB

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BIOGEN MA INC.

US Patent


Assay Description
ATX (Autotaxin) is a 125 KDa glycoprotein with lysophospholipase D (LPLD) activity that generates the bioactive lipid lysophosphatidic acid (LPA) fro...


US Patent US10273234 (2019)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM382156
PNG
(1-((5-((trans-4-ethylcyclohexyl)oxy)naphthalen-2-y...)
Show SMILES CC[C@H]1CC[C@@H](CC1)Oc1cccc2cc(CN3CC(C3)C(O)=O)ccc12
Show InChI InChI=1S/C23H29NO3/c1-2-16-6-9-20(10-7-16)27-22-5-3-4-18-12-17(8-11-21(18)22)13-24-14-19(15-24)23(25)26/h3-5,8,11-12,16,19-20H,2,6-7,9-10,13-15H2,1H3,(H,25,26)/t16-,20-
PDB

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n/an/a 2.75E+3n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
ATX (Autotaxin) is a 125 KDa glycoprotein with lysophospholipase D (LPLD) activity that generates the bioactive lipid lysophosphatidic acid (LPA) fro...


US Patent US10273234 (2019)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM382149
PNG
(3-(((5-((trans-4-(tert-butyl)cyclohexyl)oxy)naphth...)
Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)Oc1cccc2cc(CNC3CC(C3)C(O)=O)ccc12
Show InChI InChI=1S/C26H35NO3/c1-26(2,3)20-8-10-22(11-9-20)30-24-6-4-5-18-13-17(7-12-23(18)24)16-27-21-14-19(15-21)25(28)29/h4-7,12-13,19-22,27H,8-11,14-16H2,1-3H3,(H,28,29)/t19?,20-,21?,22-
PDB

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BIOGEN MA INC.

US Patent


Assay Description
ATX (Autotaxin) is a 125 KDa glycoprotein with lysophospholipase D (LPLD) activity that generates the bioactive lipid lysophosphatidic acid (LPA) fro...


US Patent US10273234 (2019)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM382148
PNG
(2-((5-((trans-4-(tert-butyl)cyclohexyl)oxy)naphtha...)
Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)Oc1cccc2cc(CN3CC4CC(CC4C3)C(O)=O)ccc12
Show InChI InChI=1S/C29H39NO3/c1-29(2,3)24-8-10-25(11-9-24)33-27-6-4-5-20-13-19(7-12-26(20)27)16-30-17-22-14-21(28(31)32)15-23(22)18-30/h4-7,12-13,21-25H,8-11,14-18H2,1-3H3,(H,31,32)/t21?,22?,23?,24-,25-
PDB

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BIOGEN MA INC.

US Patent


Assay Description
ATX (Autotaxin) is a 125 KDa glycoprotein with lysophospholipase D (LPLD) activity that generates the bioactive lipid lysophosphatidic acid (LPA) fro...


US Patent US10273234 (2019)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM382157
PNG
(1-((5-((trans-4-(trifluoromethyl)cyclohexyl)oxy)na...)
Show SMILES OC(=O)C1CN(Cc2ccc3c(O[C@H]4CC[C@@H](CC4)C(F)(F)F)cccc3c2)C1
Show InChI InChI=1S/C22H24F3NO3/c23-22(24,25)17-5-7-18(8-6-17)29-20-3-1-2-15-10-14(4-9-19(15)20)11-26-12-16(13-26)21(27)28/h1-4,9-10,16-18H,5-8,11-13H2,(H,27,28)/t17-,18-
PDB

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n/an/a 2.75E+3n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
ATX (Autotaxin) is a 125 KDa glycoprotein with lysophospholipase D (LPLD) activity that generates the bioactive lipid lysophosphatidic acid (LPA) fro...


US Patent US10273234 (2019)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM382152
PNG
(1-((5-((cis-4-ethylcyclohexyl)oxy)naphthalen-2-yl)...)
Show SMILES CC[C@H]1CC[C@H](CC1)Oc1cccc2cc(CN3CCC(CC3)C(O)=O)ccc12
Show InChI InChI=1S/C25H33NO3/c1-2-18-6-9-22(10-7-18)29-24-5-3-4-21-16-19(8-11-23(21)24)17-26-14-12-20(13-15-26)25(27)28/h3-5,8,11,16,18,20,22H,2,6-7,9-10,12-15,17H2,1H3,(H,27,28)/t18-,22+
PDB

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n/an/a 2.75E+3n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
ATX (Autotaxin) is a 125 KDa glycoprotein with lysophospholipase D (LPLD) activity that generates the bioactive lipid lysophosphatidic acid (LPA) fro...


US Patent US10273234 (2019)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM382146
PNG
(8-((5-((trans-4-(tert-butyl)cyclohexyl)oxy)naphtha...)
Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)Oc1cccc2cc(CN3C4CCC3CC(C4)C(O)=O)ccc12
Show InChI InChI=1S/C29H39NO3/c1-29(2,3)22-8-12-25(13-9-22)33-27-6-4-5-20-15-19(7-14-26(20)27)18-30-23-10-11-24(30)17-21(16-23)28(31)32/h4-7,14-15,21-25H,8-13,16-18H2,1-3H3,(H,31,32)/t21?,22-,23?,24?,25-
PDB

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BIOGEN MA INC.

US Patent


Assay Description
ATX (Autotaxin) is a 125 KDa glycoprotein with lysophospholipase D (LPLD) activity that generates the bioactive lipid lysophosphatidic acid (LPA) fro...


US Patent US10273234 (2019)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM382162
PNG
(1-((5-((trans-4-(tert-butyl)cyclohexyl)oxy)naphtha...)
Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)Oc1cccc2cc(CN3CCCC(CC3)C(O)=O)ccc12
Show InChI InChI=1S/C28H39NO3/c1-28(2,3)23-10-12-24(13-11-23)32-26-8-4-6-22-18-20(9-14-25(22)26)19-29-16-5-7-21(15-17-29)27(30)31/h4,6,8-9,14,18,21,23-24H,5,7,10-13,15-17,19H2,1-3H3,(H,30,31)/t21?,23-,24-
PDB

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BIOGEN MA INC.

US Patent


Assay Description
ATX (Autotaxin) is a 125 KDa glycoprotein with lysophospholipase D (LPLD) activity that generates the bioactive lipid lysophosphatidic acid (LPA) fro...


US Patent US10273234 (2019)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM382166
PNG
(1-((5-((trans-4-phenylcyclohexyl)oxy)naphthalen-2-...)
Show SMILES OC(=O)C1CN(Cc2ccc3c(O[C@H]4CC[C@@H](CC4)c4ccccc4)cccc3c2)C1
Show InChI InChI=1S/C27H29NO3/c29-27(30)23-17-28(18-23)16-19-9-14-25-22(15-19)7-4-8-26(25)31-24-12-10-21(11-13-24)20-5-2-1-3-6-20/h1-9,14-15,21,23-24H,10-13,16-18H2,(H,29,30)/t21-,24-
PDB

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BIOGEN MA INC.

US Patent


Assay Description
ATX (Autotaxin) is a 125 KDa glycoprotein with lysophospholipase D (LPLD) activity that generates the bioactive lipid lysophosphatidic acid (LPA) fro...


US Patent US10273234 (2019)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM382170
PNG
(1-((5-(heptyloxy)naphthalen-2-yl)methyl)piperidine...)
Show SMILES CCCCCCCOc1cccc2cc(CN3CCC(CC3)C(O)=O)ccc12
Show InChI InChI=1S/C24H33NO3/c1-2-3-4-5-6-16-28-23-9-7-8-21-17-19(10-11-22(21)23)18-25-14-12-20(13-15-25)24(26)27/h7-11,17,20H,2-6,12-16,18H2,1H3,(H,26,27)
PDB

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BIOGEN MA INC.

US Patent


Assay Description
ATX (Autotaxin) is a 125 KDa glycoprotein with lysophospholipase D (LPLD) activity that generates the bioactive lipid lysophosphatidic acid (LPA) fro...


US Patent US10273234 (2019)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM382164
PNG
(1-((5-((cis-4-isopropylcyclohexyl)oxy)naphthalen-2...)
Show SMILES CC(C)[C@@H]1CC[C@@H](CC1)Oc1cccc2cc(CN3CCC(CC3)C(O)=O)ccc12
Show InChI InChI=1S/C26H35NO3/c1-18(2)20-7-9-23(10-8-20)30-25-5-3-4-22-16-19(6-11-24(22)25)17-27-14-12-21(13-15-27)26(28)29/h3-6,11,16,18,20-21,23H,7-10,12-15,17H2,1-2H3,(H,28,29)/t20-,23+
PDB

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BIOGEN MA INC.

US Patent


Assay Description
ATX (Autotaxin) is a 125 KDa glycoprotein with lysophospholipase D (LPLD) activity that generates the bioactive lipid lysophosphatidic acid (LPA) fro...


US Patent US10273234 (2019)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM382169
PNG
(1-((5-((trans-4-cyclopentylcyclohexyl)oxy)naphthal...)
Show SMILES OC(=O)C1CN(Cc2ccc3c(O[C@H]4CC[C@@H](CC4)C4CCCC4)cccc3c2)C1
Show InChI InChI=1S/C26H33NO3/c28-26(29)22-16-27(17-22)15-18-8-13-24-21(14-18)6-3-7-25(24)30-23-11-9-20(10-12-23)19-4-1-2-5-19/h3,6-8,13-14,19-20,22-23H,1-2,4-5,9-12,15-17H2,(H,28,29)/t20-,23-
PDB

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US Patent


Assay Description
ATX (Autotaxin) is a 125 KDa glycoprotein with lysophospholipase D (LPLD) activity that generates the bioactive lipid lysophosphatidic acid (LPA) fro...


US Patent US10273234 (2019)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM382160
PNG
(9-((5-((trans-4-(tert-butyl)cyclohexyl)oxy)naphtha...)
Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)Oc1cccc2cc(CN3C4CCCC3CC(C4)C(O)=O)ccc12
Show InChI InChI=1S/C30H41NO3/c1-30(2,3)23-11-13-26(14-12-23)34-28-9-4-6-21-16-20(10-15-27(21)28)19-31-24-7-5-8-25(31)18-22(17-24)29(32)33/h4,6,9-10,15-16,22-26H,5,7-8,11-14,17-19H2,1-3H3,(H,32,33)/t22?,23-,24?,25?,26-
PDB

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n/an/a>5.00E+3n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
ATX (Autotaxin) is a 125 KDa glycoprotein with lysophospholipase D (LPLD) activity that generates the bioactive lipid lysophosphatidic acid (LPA) fro...


US Patent US10273234 (2019)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM382167
PNG
(1-((5-((trans-4-isopropylcyclohexyl)oxy)naphthalen...)
Show SMILES CC(C)[C@H]1CC[C@@H](CC1)Oc1cccc2cc(CN3CC(C3)C(O)=O)ccc12
Show InChI InChI=1S/C24H31NO3/c1-16(2)18-7-9-21(10-8-18)28-23-5-3-4-19-12-17(6-11-22(19)23)13-25-14-20(15-25)24(26)27/h3-6,11-12,16,18,20-21H,7-10,13-15H2,1-2H3,(H,26,27)/t18-,21-
PDB

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n/an/a>5.00E+3n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
ATX (Autotaxin) is a 125 KDa glycoprotein with lysophospholipase D (LPLD) activity that generates the bioactive lipid lysophosphatidic acid (LPA) fro...


US Patent US10273234 (2019)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM382165
PNG
(1-((5-((trans-4-methylcyclohexyl)oxy)naphthalen-2-...)
Show SMILES C[C@H]1CC[C@@H](CC1)Oc1cccc2cc(CN3CC(C3)C(O)=O)ccc12
Show InChI InChI=1S/C22H27NO3/c1-15-5-8-19(9-6-15)26-21-4-2-3-17-11-16(7-10-20(17)21)12-23-13-18(14-23)22(24)25/h2-4,7,10-11,15,18-19H,5-6,8-9,12-14H2,1H3,(H,24,25)/t15-,19-
PDB

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n/an/a>5.00E+3n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
ATX (Autotaxin) is a 125 KDa glycoprotein with lysophospholipase D (LPLD) activity that generates the bioactive lipid lysophosphatidic acid (LPA) fro...


US Patent US10273234 (2019)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM382163
PNG
(1-((5-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naph...)
Show SMILES OC(=O)C1CCN(Cc2ccc3c(O[C@H]4CC[C@H](CC4)C(F)(F)F)cccc3c2)CC1
Show InChI InChI=1S/C24H28F3NO3/c25-24(26,27)19-5-7-20(8-6-19)31-22-3-1-2-18-14-16(4-9-21(18)22)15-28-12-10-17(11-13-28)23(29)30/h1-4,9,14,17,19-20H,5-8,10-13,15H2,(H,29,30)/t19-,20+
PDB

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n/an/a>5.00E+3n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
ATX (Autotaxin) is a 125 KDa glycoprotein with lysophospholipase D (LPLD) activity that generates the bioactive lipid lysophosphatidic acid (LPA) fro...


US Patent US10273234 (2019)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM382172
PNG
(1-((5-((cis-4-methylcyclohexyl)oxy)naphthalen-2-yl...)
Show SMILES C[C@H]1CC[C@H](CC1)Oc1cccc2cc(CN3CCC(CC3)C(O)=O)ccc12
Show InChI InChI=1S/C24H31NO3/c1-17-5-8-21(9-6-17)28-23-4-2-3-20-15-18(7-10-22(20)23)16-25-13-11-19(12-14-25)24(26)27/h2-4,7,10,15,17,19,21H,5-6,8-9,11-14,16H2,1H3,(H,26,27)/t17-,21+
PDB

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BIOGEN MA INC.

US Patent


Assay Description
ATX (Autotaxin) is a 125 KDa glycoprotein with lysophospholipase D (LPLD) activity that generates the bioactive lipid lysophosphatidic acid (LPA) fro...


US Patent US10273234 (2019)

More data for this
Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


(Homo sapiens (Human))
BDBM382168
PNG
(1-((5-((trans-4-butylcyclohexyl)oxy)naphthalen-2-y...)
Show SMILES CCCC[C@H]1CC[C@@H](CC1)Oc1cccc2cc(CN3CC(C3)C(O)=O)ccc12
Show InChI InChI=1S/C25H33NO3/c1-2-3-5-18-8-11-22(12-9-18)29-24-7-4-6-20-14-19(10-13-23(20)24)15-26-16-21(17-26)25(27)28/h4,6-7,10,13-14,18,21-22H,2-3,5,8-9,11-12,15-17H2,1H3,(H,27,28)/t18-,22-
PDB

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US Patent
n/an/a>5.00E+3n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
ATX (Autotaxin) is a 125 KDa glycoprotein with lysophospholipase D (LPLD) activity that generates the bioactive lipid lysophosphatidic acid (LPA) fro...


US Patent US10273234 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%