BindingDB logo
myBDB logout

Patent code US10273244

Compile Data Set for Download or QSAR

Found 348 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM382217
PNG
(US10273244, Example 64)
Show SMILES Cn1c(SCCCN2C[C@@H]3CCN([C@@H]3C2)c2ccc(F)cc2)nnc1C1CCCCC1
Show InChI InChI=1S/C24H34FN5S/c1-28-23(18-6-3-2-4-7-18)26-27-24(28)31-15-5-13-29-16-19-12-14-30(22(19)17-29)21-10-8-20(25)9-11-21/h8-11,18-19,22H,2-7,12-17H2,1H3/t19-,22+/m0/s1
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.182n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50154890
PNG
(CHEMBL3774425 | US10273244, Example 113)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2cccc(c2)C(F)(F)F)nnc1-c1cnccn1
Show InChI InChI=1/C23H26F3N7S/c1-31-21(19-13-27-7-8-28-19)29-30-22(31)34-11-3-9-32-14-16-6-10-33(20(16)15-32)18-5-2-4-17(12-18)23(24,25)26/h2,4-5,7-8,12-13,16,20H,3,6,9-11,14-15H2,1H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
0.224n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50154897
PNG
(CHEMBL3774463 | US10273244, Example 56)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(cc2)C(F)(F)F)nnc1C1CCCCC1
Show InChI InChI=1/C25H34F3N5S/c1-31-23(18-6-3-2-4-7-18)29-30-24(31)34-15-5-13-32-16-19-12-14-33(22(19)17-32)21-10-8-20(9-11-21)25(26,27)28/h8-11,18-19,22H,2-7,12-17H2,1H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
0.331n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50154878
PNG
(CHEMBL3774895 | US10273244, Example 114)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2cccc(OC(F)(F)F)c2)nnc1-c1cnccn1
Show InChI InChI=1/C23H26F3N7OS/c1-31-21(19-13-27-7-8-28-19)29-30-22(31)35-11-3-9-32-14-16-6-10-33(20(16)15-32)17-4-2-5-18(12-17)34-23(24,25)26/h2,4-5,7-8,12-13,16,20H,3,6,9-11,14-15H2,1H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
0.355n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM382214
PNG
(US10273244, Example 59)
Show SMILES Cn1c(SCCCN2C[C@@H]3CCN([C@@H]3C2)c2ccc(cc2)C(F)(F)F)nnc1C1CCCCC1
Show InChI InChI=1S/C25H34F3N5S/c1-31-23(18-6-3-2-4-7-18)29-30-24(31)34-15-5-13-32-16-19-12-14-33(22(19)17-32)21-10-8-20(9-11-21)25(26,27)28/h8-11,18-19,22H,2-7,12-17H2,1H3/t19-,22+/m0/s1
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.398n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50154898
PNG
(CHEMBL3774431 | US10273244, Example 61)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(F)cc2)nnc1C1CCCCC1
Show InChI InChI=1/C24H34FN5S/c1-28-23(18-6-3-2-4-7-18)26-27-24(28)31-15-5-13-29-16-19-12-14-30(22(19)17-29)21-10-8-20(25)9-11-21/h8-11,18-19,22H,2-7,12-17H2,1H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
0.407n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM382215
PNG
(US10273244, Example 60)
Show SMILES Cn1c(SCCCN2C[C@H]3CCN([C@H]3C2)c2ccc(cc2)C(F)(F)F)nnc1C1CCCCC1
Show InChI InChI=1S/C25H34F3N5S/c1-31-23(18-6-3-2-4-7-18)29-30-24(31)34-15-5-13-32-16-19-12-14-33(22(19)17-32)21-10-8-20(9-11-21)25(26,27)28/h8-11,18-19,22H,2-7,12-17H2,1H3/t19-,22+/m1/s1
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.407n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50154894
PNG
(CHEMBL3775338 | US10273244, Example 28)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2CC3CCN(C3C2)c2cc(Cl)cc(Cl)c2)n1C
Show InChI InChI=1/C22H26Cl2N6OS/c1-14-20(31-13-25-14)21-26-27-22(28(21)2)32-7-3-5-29-11-15-4-6-30(19(15)12-29)18-9-16(23)8-17(24)10-18/h8-10,13,15,19H,3-7,11-12H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
0.417n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM382318
PNG
(US10273244, Example 199)
Show SMILES Cn1c(SCCCN2C[C@H]3CCN([C@H]3C2)c2ccc(F)cc2)nnc1-c1ccc(nc1)C(N)=O
Show InChI InChI=1S/C24H28FN7OS/c1-30-23(16-3-8-20(22(26)33)27-13-16)28-29-24(30)34-12-2-10-31-14-17-9-11-32(21(17)15-31)19-6-4-18(25)5-7-19/h3-8,13,17,21H,2,9-12,14-15H2,1H3,(H2,26,33)/t17-,21+/m1/s1
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.513n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM382317
PNG
(US10273244, Example 198)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(F)cc2)nnc1-c1ccc(nc1)C(N)=O
Show InChI InChI=1S/C24H28FN7OS/c1-30-23(16-3-8-20(22(26)33)27-13-16)28-29-24(30)34-12-2-10-31-14-17-9-11-32(21(17)15-31)19-6-4-18(25)5-7-19/h3-8,13,17,21H,2,9-12,14-15H2,1H3,(H2,26,33)
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.525n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM382315
PNG
(US10273244, Example 196)
Show SMILES Cn1c(SCCCN2C[C@H]3CCN([C@H]3C2)c2ccc(cc2)C(F)(F)F)nnc1-c1ccc(nc1)C(N)=O
Show InChI InChI=1S/C25H28F3N7OS/c1-33-23(16-3-8-20(22(29)36)30-13-16)31-32-24(33)37-12-2-10-34-14-17-9-11-35(21(17)15-34)19-6-4-18(5-7-19)25(26,27)28/h3-8,13,17,21H,2,9-12,14-15H2,1H3,(H2,29,36)/t17-,21+/m1/s1
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.589n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM382324
PNG
(US10273244, Example 205)
Show SMILES Cn1c(SCCCN2C[C@H]3CCN([C@H]3C2)c2c(F)cc(F)cc2F)nnc1-c1ccc(nc1)C(N)=O
Show InChI InChI=1S/C24H26F3N7OS/c1-32-23(14-3-4-19(22(28)35)29-11-14)30-31-24(32)36-8-2-6-33-12-15-5-7-34(20(15)13-33)21-17(26)9-16(25)10-18(21)27/h3-4,9-11,15,20H,2,5-8,12-13H2,1H3,(H2,28,35)/t15-,20+/m1/s1
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.646n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM382178
PNG
(US10273244, Example 10)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2C[C@@H]3CCN([C@@H]3C2)c2cccc(c2)C#N)n1C
Show InChI InChI=1S/C23H27N7OS/c1-16-21(31-15-25-16)22-26-27-23(28(22)2)32-10-4-8-29-13-18-7-9-30(20(18)14-29)19-6-3-5-17(11-19)12-24/h3,5-6,11,15,18,20H,4,7-10,13-14H2,1-2H3/t18-,20+/m0/s1
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.646n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM382314
PNG
(US10273244, Example 195)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(cc2)C(F)(F)F)nnc1-c1ccc(nc1)C(N)=O
Show InChI InChI=1S/C25H28F3N7OS/c1-33-23(16-3-8-20(22(29)36)30-13-16)31-32-24(33)37-12-2-10-34-14-17-9-11-35(21(17)15-34)19-6-4-18(5-7-19)25(26,27)28/h3-8,13,17,21H,2,9-12,14-15H2,1H3,(H2,29,36)
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.776n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM382218
PNG
(US10273244, Example 65)
Show SMILES Cn1c(SCCCN2C[C@H]3CCN([C@H]3C2)c2ccc(F)cc2)nnc1C1CCCCC1
Show InChI InChI=1S/C24H34FN5S/c1-28-23(18-6-3-2-4-7-18)26-27-24(28)31-15-5-13-29-16-19-12-14-30(22(19)17-29)21-10-8-20(25)9-11-21/h8-11,18-19,22H,2-7,12-17H2,1H3/t19-,22+/m1/s1
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.832n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM382301
PNG
(US10273244, Example 178)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2cccc(c2)C(F)(F)F)nnc1-c1ccc(=O)[nH]c1
Show InChI InChI=1/C24H27F3N6OS/c1-31-22(16-6-7-21(34)28-13-16)29-30-23(31)35-11-3-9-32-14-17-8-10-33(20(17)15-32)19-5-2-4-18(12-19)24(25,26)27/h2,4-7,12-13,17,20H,3,8-11,14-15H2,1H3,(H,28,34)
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.851n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50154877
PNG
(CHEMBL3774621 | US10273244, Example 96)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccccc2OC(F)(F)F)nnc1-c1cnccn1
Show InChI InChI=1/C23H26F3N7OS/c1-31-21(17-13-27-8-9-28-17)29-30-22(31)35-12-4-10-32-14-16-7-11-33(19(16)15-32)18-5-2-3-6-20(18)34-23(24,25)26/h2-3,5-6,8-9,13,16,19H,4,7,10-12,14-15H2,1H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
0.851n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM382188
PNG
(US10273244, Example 23)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2C[C@H]3CCN([C@H]3C2)c2ccc(F)cc2)n1C
Show InChI InChI=1S/C22H27FN6OS/c1-15-20(30-14-24-15)21-25-26-22(27(21)2)31-11-3-9-28-12-16-8-10-29(19(16)13-28)18-6-4-17(23)5-7-18/h4-7,14,16,19H,3,8-13H2,1-2H3/t16-,19+/m1/s1
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.871n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM382203
PNG
(US10273244, Example 44)
Show SMILES Cn1c(SCCCN2C[C@@H]3CCN([C@@H]3C2)c2ccc(F)cc2)nnc1C1CCOCC1
Show InChI InChI=1S/C23H32FN5OS/c1-27-22(17-8-12-30-13-9-17)25-26-23(27)31-14-2-10-28-15-18-7-11-29(21(18)16-28)20-5-3-19(24)4-6-20/h3-6,17-18,21H,2,7-16H2,1H3/t18-,21+/m0/s1
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.912n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM382316
PNG
(US10273244, Example 197)
Show SMILES Cn1c(SCCCN2C[C@@H]3CCN([C@@H]3C2)c2ccc(cc2)C(F)(F)F)nnc1-c1ccc(nc1)C(N)=O
Show InChI InChI=1S/C25H28F3N7OS/c1-33-23(16-3-8-20(22(29)36)30-13-16)31-32-24(33)37-12-2-10-34-14-17-9-11-35(21(17)15-34)19-6-4-18(5-7-19)25(26,27)28/h3-8,13,17,21H,2,9-12,14-15H2,1H3,(H2,29,36)/t17-,21+/m0/s1
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
0.933n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM382323
PNG
(US10273244, Example 204)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2c(F)cc(F)cc2F)nnc1-c1ccc(nc1)C(N)=O
Show InChI InChI=1S/C24H26F3N7OS/c1-32-23(14-3-4-19(22(28)35)29-11-14)30-31-24(32)36-8-2-6-33-12-15-5-7-34(20(15)13-33)21-17(26)9-16(25)10-18(21)27/h3-4,9-11,15,20H,2,5-8,12-13H2,1H3,(H2,28,35)
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
1.05n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50154891
PNG
(CHEMBL3775872 | US10273244, Example 25)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2CC3CCN(C3C2)c2ccccc2OC(F)(F)F)n1C
Show InChI InChI=1/C23H27F3N6O2S/c1-15-20(33-14-27-15)21-28-29-22(30(21)2)35-11-5-9-31-12-16-8-10-32(18(16)13-31)17-6-3-4-7-19(17)34-23(24,25)26/h3-4,6-7,14,16,18H,5,8-13H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
1.07n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50154869
PNG
(CHEMBL3774519 | US10273244, Example 133)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2c(F)cc(F)cc2F)nnc1-c1cnccn1
Show InChI InChI=1/C22H24F3N7S/c1-30-21(18-11-26-4-5-27-18)28-29-22(30)33-8-2-6-31-12-14-3-7-32(19(14)13-31)20-16(24)9-15(23)10-17(20)25/h4-5,9-11,14,19H,2-3,6-8,12-13H2,1H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
1.07n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM382335
PNG
(US10273244, Example 221)
Show SMILES Cn1c(SCCCN2C[C@H]3CCN([C@H]3C2)c2ccc(cc2)C(F)(F)F)nnc1C1CCC(O)CC1
Show InChI InChI=1S/C25H34F3N5OS/c1-31-23(17-3-9-21(34)10-4-17)29-30-24(31)35-14-2-12-32-15-18-11-13-33(22(18)16-32)20-7-5-19(6-8-20)25(26,27)28/h5-8,17-18,21-22,34H,2-4,9-16H2,1H3/t17?,18-,21?,22+/m1/s1
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
1.10n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM382186
PNG
(US10273244, Example 21)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2C[C@H]3CCN([C@H]3C2)c2ccc(cc2F)C(F)(F)F)n1C
Show InChI InChI=1S/C23H26F4N6OS/c1-14-20(34-13-28-14)21-29-30-22(31(21)2)35-9-3-7-32-11-15-6-8-33(19(15)12-32)18-5-4-16(10-17(18)24)23(25,26)27/h4-5,10,13,15,19H,3,6-9,11-12H2,1-2H3/t15-,19+/m1/s1
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
1.20n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM382183
PNG
(US10273244, Example 16)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2C[C@H]3CCN([C@H]3C2)c2ccccc2)n1C
Show InChI InChI=1S/C22H28N6OS/c1-16-20(29-15-23-16)21-24-25-22(26(21)2)30-12-6-10-27-13-17-9-11-28(19(17)14-27)18-7-4-3-5-8-18/h3-5,7-8,15,17,19H,6,9-14H2,1-2H3/t17-,19+/m1/s1
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
1.23n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM382333
PNG
(US10273244, Example 218)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(cc2)C(F)(F)F)nnc1C1CCC(O)CC1
Show InChI InChI=1S/C25H34F3N5OS/c1-31-23(17-3-9-21(34)10-4-17)29-30-24(31)35-14-2-12-32-15-18-11-13-33(22(18)16-32)20-7-5-19(6-8-20)25(26,27)28/h5-8,17-18,21-22,34H,2-4,9-16H2,1H3
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
1.26n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50154867
PNG
(CHEMBL3775810 | US10273244, Example 134)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(cc2)C(F)(F)F)nnc1-c1ccncn1
Show InChI InChI=1/C23H26F3N7S/c1-31-21(19-7-9-27-15-28-19)29-30-22(31)34-12-2-10-32-13-16-8-11-33(20(16)14-32)18-5-3-17(4-6-18)23(24,25)26/h3-7,9,15-16,20H,2,8,10-14H2,1H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
1.32n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM382322
PNG
(US10273244, Example 203)
Show SMILES Cn1c(SCCCN2C[C@@H]3CCN([C@@H]3C2)c2c(F)cccc2F)nnc1-c1ccc(nc1)C(N)=O
Show InChI InChI=1S/C24H27F2N7OS/c1-31-23(15-6-7-19(22(27)34)28-12-15)29-30-24(31)35-11-3-9-32-13-16-8-10-33(20(16)14-32)21-17(25)4-2-5-18(21)26/h2,4-7,12,16,20H,3,8-11,13-14H2,1H3,(H2,27,34)/t16-,20+/m0/s1
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
1.32n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50154850
PNG
(CHEMBL3774588 | US10273244, Example 22)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2CC3CCN(C3C2)c2ccc(F)cc2)n1C
Show InChI InChI=1/C22H27FN6OS/c1-15-20(30-14-24-15)21-25-26-22(27(21)2)31-11-3-9-28-12-16-8-10-29(19(16)13-28)18-6-4-17(23)5-7-18/h4-7,14,16,19H,3,8-13H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
1.38n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM382320
PNG
(US10273244, Example 201)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2c(F)cccc2F)nnc1-c1ccc(nc1)C(N)=O
Show InChI InChI=1S/C24H27F2N7OS/c1-31-23(15-6-7-19(22(27)34)28-12-15)29-30-24(31)35-11-3-9-32-13-16-8-10-33(20(16)14-32)21-17(25)4-2-5-18(21)26/h2,4-7,12,16,20H,3,8-11,13-14H2,1H3,(H2,27,34)
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
1.41n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50154895
PNG
(CHEMBL3775534 | US10273244, Example 7)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2CC3CCN(C3C2)c2cccc(c2)C#N)n1C
Show InChI InChI=1/C23H27N7OS/c1-16-21(31-15-25-16)22-26-27-23(28(22)2)32-10-4-8-29-13-18-7-9-30(20(18)14-29)19-6-3-5-17(11-19)12-24/h3,5-6,11,15,18,20H,4,7-10,13-14H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
1.41n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50154851
PNG
(CHEMBL3774683 | US10273244, Example 89)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(cc2)C(F)(F)F)nnc1-c1cnccn1
Show InChI InChI=1/C23H26F3N7S/c1-31-21(19-13-27-8-9-28-19)29-30-22(31)34-12-2-10-32-14-16-7-11-33(20(16)15-32)18-5-3-17(4-6-18)23(24,25)26/h3-6,8-9,13,16,20H,2,7,10-12,14-15H2,1H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
1.45n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM382269
PNG
(US10273244, Example 138)
Show SMILES Cn1c(SCCCN2C[C@H]3CCN([C@H]3C2)c2ccc(cc2)C(F)(F)F)nnc1-c1ccncn1
Show InChI InChI=1S/C23H26F3N7S/c1-31-21(19-7-9-27-15-28-19)29-30-22(31)34-12-2-10-32-13-16-8-11-33(20(16)14-32)18-5-3-17(4-6-18)23(24,25)26/h3-7,9,15-16,20H,2,8,10-14H2,1H3/t16-,20+/m1/s1
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
1.48n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50154896
PNG
(CHEMBL3774462 | US10273244, Example 51)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(cc2)C(F)(F)F)nnc1C1CCCC1
Show InChI InChI=1/C24H32F3N5S/c1-30-22(17-5-2-3-6-17)28-29-23(30)33-14-4-12-31-15-18-11-13-32(21(18)16-31)20-9-7-19(8-10-20)24(25,26)27/h7-10,17-18,21H,2-6,11-16H2,1H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
1.48n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM382270
PNG
(US10273244, Example 139)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(F)cc2)nnc1-c1ccncn1
Show InChI InChI=1S/C22H26FN7S/c1-28-21(19-7-9-24-15-25-19)26-27-22(28)31-12-2-10-29-13-16-8-11-30(20(16)14-29)18-5-3-17(23)4-6-18/h3-7,9,15-16,20H,2,8,10-14H2,1H3
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
1.48n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM382307
PNG
(US10273244, Example 188)
Show SMILES Cn1nccc1-c1nnc(SCCCN2C[C@@H]3CCN([C@@H]3C2)c2ccccc2C(F)(F)F)n1C
Show InChI InChI=1S/C23H28F3N7S/c1-30-21(19-8-10-27-31(19)2)28-29-22(30)34-13-5-11-32-14-16-9-12-33(20(16)15-32)18-7-4-3-6-17(18)23(24,25)26/h3-4,6-8,10,16,20H,5,9,11-15H2,1-2H3/t16-,20+/m0/s1
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
1.62n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50154902
PNG
(CHEMBL3774540 | US10273244, Example 2)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2CC3CCN(C3C2)c2ccc(cc2)C(F)(F)F)n1C
Show InChI InChI=1/C23H27F3N6OS/c1-15-20(33-14-27-15)21-28-29-22(30(21)2)34-11-3-9-31-12-16-8-10-32(19(16)13-31)18-6-4-17(5-7-18)23(24,25)26/h4-7,14,16,19H,3,8-13H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
1.74n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM382283
PNG
(US10273244, Example 158)
Show SMILES Cn1c(SCCCN2C[C@@H]3CCN([C@@H]3C2)c2ccccc2C(F)(F)F)nnc1-c1ccncc1
Show InChI InChI=1S/C24H27F3N6S/c1-31-22(17-7-10-28-11-8-17)29-30-23(31)34-14-4-12-32-15-18-9-13-33(21(18)16-32)20-6-3-2-5-19(20)24(25,26)27/h2-3,5-8,10-11,18,21H,4,9,12-16H2,1H3/t18-,21+/m0/s1
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
1.78n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50154859
PNG
(CHEMBL3775554 | US10273244, Example 160)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(cc2)C(F)(F)F)nnc1-c1ccccn1
Show InChI InChI=1/C24H27F3N6S/c1-31-22(20-5-2-3-11-28-20)29-30-23(31)34-14-4-12-32-15-17-10-13-33(21(17)16-32)19-8-6-18(7-9-19)24(25,26)27/h2-3,5-9,11,17,21H,4,10,12-16H2,1H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
1.78n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM382319
PNG
(US10273244, Example 200)
Show SMILES Cn1c(SCCCN2C[C@@H]3CCN([C@@H]3C2)c2ccc(F)cc2)nnc1-c1ccc(nc1)C(N)=O
Show InChI InChI=1S/C24H28FN7OS/c1-30-23(16-3-8-20(22(26)33)27-13-16)28-29-24(30)34-12-2-10-31-14-17-9-11-32(21(17)15-31)19-6-4-18(25)5-7-19/h3-8,13,17,21H,2,9-12,14-15H2,1H3,(H2,26,33)/t17-,21+/m0/s1
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
1.78n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50154860
PNG
(CHEMBL3774490 | US10273244, Example 153)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(cc2)C(F)(F)F)nnc1-c1ccncc1
Show InChI InChI=1/C24H27F3N6S/c1-31-22(17-7-10-28-11-8-17)29-30-23(31)34-14-2-12-32-15-18-9-13-33(21(18)16-32)20-5-3-19(4-6-20)24(25,26)27/h3-8,10-11,18,21H,2,9,12-16H2,1H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
1.86n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM382230
PNG
(US10273244, Example 85)
Show SMILES Cn1c(SCCCN2C[C@H]3CCN([C@H]3C2)c2ccc(cc2)C(F)(F)F)nnc1N1CCOCC1
Show InChI InChI=1S/C23H31F3N6OS/c1-29-21(31-10-12-33-13-11-31)27-28-22(29)34-14-2-8-30-15-17-7-9-32(20(17)16-30)19-5-3-18(4-6-19)23(24,25)26/h3-6,17,20H,2,7-16H2,1H3/t17-,20+/m1/s1
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
2n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM382236
PNG
(US10273244, Example 93)
Show SMILES Cn1c(SCCCN2C[C@H]3CCN([C@H]3C2)c2ccc(cc2)C(F)(F)F)nnc1-c1cnccn1
Show InChI InChI=1S/C23H26F3N7S/c1-31-21(19-13-27-8-9-28-19)29-30-22(31)34-12-2-10-32-14-16-7-11-33(20(16)15-32)18-5-3-17(4-6-18)23(24,25)26/h3-6,8-9,13,16,20H,2,7,10-12,14-15H2,1H3/t16-,20+/m1/s1
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
2n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50154843
PNG
(CHEMBL3775226 | US10273244, Example 17)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2CC3CCN(C3C2)c2ccc(cc2F)C(F)(F)F)n1C
Show InChI InChI=1/C23H26F4N6OS/c1-14-20(34-13-28-14)21-29-30-22(31(21)2)35-9-3-7-32-11-15-6-8-33(19(15)12-32)18-5-4-16(10-17(18)24)23(25,26)27/h4-5,10,13,15,19H,3,6-9,11-12H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
2.04n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50154888
PNG
(CHEMBL3774996 | US10273244, Example 95)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(F)cc2)nnc1-c1cnccn1
Show InChI InChI=1/C22H26FN7S/c1-28-21(19-13-24-8-9-25-19)26-27-22(28)31-12-2-10-29-14-16-7-11-30(20(16)15-29)18-5-3-17(23)4-6-18/h3-6,8-9,13,16,20H,2,7,10-12,14-15H2,1H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
2.09n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50154875
PNG
(CHEMBL3775667 | US10273244, Example 94)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2cccc(c2)C#N)nnc1-c1cnccn1
Show InChI InChI=1/C23H26N8S/c1-29-22(20-14-25-7-8-26-20)27-28-23(29)32-11-3-9-30-15-18-6-10-31(21(18)16-30)19-5-2-4-17(12-19)13-24/h2,4-5,7-8,12,14,18,21H,3,6,9-11,15-16H2,1H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
2.09n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM382274
PNG
(US10273244, Example 145)
Show SMILES Cn1c(SCCCN2C[C@H]3CCN([C@H]3C2)c2ccc(cc2)C(F)(F)F)nnc1-c1cccnc1
Show InChI InChI=1S/C24H27F3N6S/c1-31-22(17-4-2-10-28-14-17)29-30-23(31)34-13-3-11-32-15-18-9-12-33(21(18)16-32)20-7-5-19(6-8-20)24(25,26)27/h2,4-8,10,14,18,21H,3,9,11-13,15-16H2,1H3/t18-,21+/m1/s1
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
2.14n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM382334
PNG
(US10273244, Example 219)
Show SMILES Cn1c(SCCCN2C[C@@H]3CCN([C@@H]3C2)c2ccc(cc2)C(F)(F)F)nnc1C1CCC(O)CC1
Show InChI InChI=1S/C25H34F3N5OS/c1-31-23(17-3-9-21(34)10-4-17)29-30-24(31)35-14-2-12-32-15-18-11-13-33(22(18)16-32)20-7-5-19(6-8-20)25(26,27)28/h5-8,17-18,21-22,34H,2-4,9-16H2,1H3/t17?,18-,21?,22+/m0/s1
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
2.14n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM382178
PNG
(US10273244, Example 10)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2C[C@@H]3CCN([C@@H]3C2)c2cccc(c2)C#N)n1C
Show InChI InChI=1S/C23H27N7OS/c1-16-21(31-15-25-16)22-26-27-23(28(22)2)32-10-4-8-29-13-18-7-9-30(20(18)14-29)19-6-3-5-17(11-19)12-24/h3,5-6,11,15,18,20H,4,7-10,13-14H2,1-2H3/t18-,20+/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
UniChem
US Patent
2.19n/an/an/an/an/an/an/an/a



INDIVIOR UK LIMITED

US Patent


Assay Description
Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 348 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%