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Patent code US10273259

Compile Data Set for Download or QSAR

Found 881 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382981
PNG
(US10273259, Example 692)
Show SMILES CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@H]1CC[C@@](C)(CC1)C(O)=O
Show InChI InChI=1S/C31H32F8N2O5S/c1-3-40-17-24-28(47(45,46)21-7-5-20(32)6-8-21,14-15-41(24)25(42)18-10-12-27(2,13-11-18)26(43)44)22-9-4-19(16-23(22)40)29(33,30(34,35)36)31(37,38)39/h4-9,16,18,24H,3,10-15,17H2,1-2H3,(H,43,44)/t18-,24?,27-,28?
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382638
PNG
(US10273259, Example 347 | US10273259, Example 348)
Show SMILES OC(=O)C1CCCC(C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C29H27F8NO5S/c30-20-6-8-21(9-7-20)44(42,43)26-12-13-38(24(39)17-2-1-3-18(14-17)25(40)41)23(26)11-4-16-15-19(5-10-22(16)26)27(31,28(32,33)34)29(35,36)37/h5-10,15,17-18,23H,1-4,11-14H2,(H,40,41)/t17?,18?,23-,26-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM383117
PNG
((4-fluoro-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(F)CCS(=O)(=O)CC1
Show InChI InChI=1S/C27H24F9NO5S2/c28-18-3-5-19(6-4-18)44(41,42)24-9-12-37(22(38)23(29)10-13-43(39,40)14-11-23)21(24)8-1-16-15-17(2-7-20(16)24)25(30,26(31,32)33)27(34,35)36/h2-7,15,21H,1,8-14H2/t21-,24-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382482
PNG
(US10273259, Example 191)
Show SMILES FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)C2CCS(=O)(=O)C2)c1)C(F)(F)F
Show InChI InChI=1S/C26H23ClF7NO5S2/c27-18-3-5-19(6-4-18)42(39,40)23-10-11-35(22(36)16-9-12-41(37,38)14-16)21(23)8-1-15-13-17(2-7-20(15)23)24(28,25(29,30)31)26(32,33)34/h2-7,13,16,21H,1,8-12,14H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382950
PNG
(US10273259, Example 661 | US10273259, Example 663)
Show SMILES COC(=O)C1CCN(CC1C)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C30H30F8N2O5S/c1-17-14-39(12-11-23(17)25(41)45-2)26(42)40-15-20-4-3-18-13-19(28(32,29(33,34)35)30(36,37)38)5-10-24(18)27(20,16-40)46(43,44)22-8-6-21(31)7-9-22/h5-10,13,17,20,23H,3-4,11-12,14-16H2,1-2H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382635
PNG
(US10273259, Example 344)
Show SMILES OC(=O)c1cc(Cl)c(cc1Cl)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C29H19Cl2F8NO5S/c30-21-13-19(25(42)43)22(31)12-18(21)24(41)40-10-9-26(46(44,45)17-5-3-16(32)4-6-17)20-7-2-15(11-14(20)1-8-23(26)40)27(33,28(34,35)36)29(37,38)39/h2-7,11-13,23H,1,8-10H2,(H,42,43)/t23-,26-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382866
PNG
(US10273259, Example 577)
Show SMILES OC12CCCC(CCC1)(C2)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C30H29F8NO4S/c31-20-4-6-21(7-5-20)44(42,43)27-13-14-39(24(40)25-9-1-11-26(41,17-25)12-2-10-25)23(27)16-18-15-19(3-8-22(18)27)28(32,29(33,34)35)30(36,37)38/h3-8,15,23,41H,1-2,9-14,16-17H2
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US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382439
PNG
(US10273259, Example 150)
Show SMILES OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C31H30F7NO5S/c32-29(30(33,34)35,31(36,37)38)22-7-8-23-19(12-22)6-9-24-28(23,45(43,44)17-18-4-2-1-3-5-18)10-11-39(24)25(40)20-13-27(14-20)15-21(16-27)26(41)42/h1-5,7-8,12,20-21,24H,6,9-11,13-17H2,(H,41,42)
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US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382654
PNG
(US10273259, Example 363)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)CC1CCS(=O)(=O)C1
Show InChI InChI=1S/C27H25F8NO5S2/c28-19-3-5-20(6-4-19)43(40,41)24-10-11-36(23(37)13-16-9-12-42(38,39)15-16)22(24)8-1-17-14-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,14,16,22H,1,8-13,15H2/t16?,22-,24-/m1/s1
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US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382696
PNG
(US10273259, Example 405)
Show SMILES OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C29H26Cl2F7NO5S/c30-21-9-7-19(14-22(21)31)45(43,44)26-11-12-39(24(40)15-1-3-16(4-2-15)25(41)42)23(26)10-5-17-13-18(6-8-20(17)26)27(32,28(33,34)35)29(36,37)38/h6-9,13-16,23H,1-5,10-12H2,(H,41,42)/t15-,16-,23?,26?
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US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382549
PNG
(US10273259, Example 258)
Show SMILES CN1CCC(CC1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H26F8N2O4S/c1-37-12-10-17(15-23(37)39)24(40)38-13-11-25(43(41,42)20-6-4-19(29)5-7-20)21-8-3-18(14-16(21)2-9-22(25)38)26(30,27(31,32)33)28(34,35)36/h3-8,14,17,22H,2,9-13,15H2,1H3/t17?,22-,25-/m1/s1
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382531
PNG
(US10273259, Example 240)
Show SMILES CN1CC(CC1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C27H24F8N2O4S/c1-36-14-16(13-22(36)38)23(39)37-11-10-24(42(40,41)19-6-4-18(28)5-7-19)20-8-3-17(12-15(20)2-9-21(24)37)25(29,26(30,31)32)27(33,34)35/h3-8,12,16,21H,2,9-11,13-14H2,1H3/t16?,21-,24-/m1/s1
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US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382681
PNG
(US10273259, Example 390 | US10273259, Example 391)
Show SMILES CC1CC(CCS1(=O)=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H27ClF7NO5S2/c1-16-14-18(10-13-43(16,39)40)24(38)37-12-11-25(44(41,42)21-6-4-20(29)5-7-21)22-8-3-19(15-17(22)2-9-23(25)37)26(30,27(31,32)33)28(34,35)36/h3-8,15-16,18,23H,2,9-14H2,1H3
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM383125
PNG
((1R,2S)-4-(9b-((3-fluorophenyl)sulfonyl)-7-(perflu...)
Show SMILES C[C@H]1CC(CC[C@H]1C(O)=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1
Show InChI InChI=1S/C30H29F8NO5S/c1-16-13-18(5-8-22(16)26(41)42)25(40)39-12-11-27(45(43,44)21-4-2-3-20(31)15-21)23-9-7-19(14-17(23)6-10-24(27)39)28(32,29(33,34)35)30(36,37)38/h2-4,7,9,14-16,18,22,24H,5-6,8,10-13H2,1H3,(H,41,42)/t16-,18?,22+,24?,27?/m0/s1
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US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382738
PNG
(US10273259, Example 447)
Show SMILES O[C@@H](C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(F)(F)F
Show InChI InChI=1S/C24H18F11NO4S/c25-14-3-5-15(6-4-14)41(39,40)20-9-10-36(19(38)18(37)22(27,28)29)17(20)8-1-12-11-13(2-7-16(12)20)21(26,23(30,31)32)24(33,34)35/h2-7,11,17-18,37H,1,8-10H2/t17-,18+,20-/m1/s1
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382530
PNG
(US10273259, Example 239)
Show SMILES CN1C(CCS1(=O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C26H24F8N2O5S2/c1-35-20(10-13-42(35,38)39)22(37)36-12-11-23(43(40,41)18-6-4-17(27)5-7-18)19-8-3-16(14-15(19)2-9-21(23)36)24(28,25(29,30)31)26(32,33)34/h3-8,14,20-21H,2,9-13H2,1H3/t20?,21-,23-/m1/s1
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US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382706
PNG
(US10273259, Example 415)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCOCC1
Show InChI InChI=1S/C27H25F8NO4S/c28-19-3-5-20(6-4-19)41(38,39)24-11-12-36(23(37)16-9-13-40-14-10-16)22(24)8-1-17-15-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,15-16,22H,1,8-14H2/t22-,24-/m1/s1
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US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382954
PNG
(US10273259, Example 665)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)NCC1CCS(=O)(=O)CC1
Show InChI InChI=1S/C28H28F8N2O5S2/c29-20-3-5-21(6-4-20)45(42,43)25-11-12-38(24(39)37-16-17-9-13-44(40,41)14-10-17)23(25)8-1-18-15-19(2-7-22(18)25)26(30,27(31,32)33)28(34,35)36/h2-7,15,17,23H,1,8-14,16H2,(H,37,39)/t23-,25-/m1/s1
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US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382805
PNG
(US10273259, Example 516)
Show SMILES Fc1ccc(cc1)S(=O)(=O)C12CCN(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1
Show InChI InChI=1S/C26H24F8N2O5S2/c27-17-2-4-18(5-3-17)43(40,41)23-9-10-36(22(37)15-7-11-42(38,39)12-8-15)21(23)14-35-20-13-16(1-6-19(20)23)24(28,25(29,30)31)26(32,33)34/h1-6,13,15,21,35H,7-12,14H2
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382704
PNG
(US10273259, Example 413)
Show SMILES OCC1(CCNCC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H28F8N2O4S/c29-19-3-5-20(6-4-19)43(41,42)25-11-14-38(23(40)24(16-39)9-12-37-13-10-24)22(25)8-1-17-15-18(2-7-21(17)25)26(30,27(31,32)33)28(34,35)36/h2-7,15,22,37,39H,1,8-14,16H2/t22-,25-/m1/s1
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382997
PNG
(US10273259, Example 708)
Show SMILES CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)C1CCS(=O)(=O)CC1
Show InChI InChI=1S/C27H26F8N2O5S2/c1-36-15-22-24(44(41,42)19-5-3-18(28)4-6-19,10-11-37(22)23(38)16-8-12-43(39,40)13-9-16)20-7-2-17(14-21(20)36)25(29,26(30,31)32)27(33,34)35/h2-7,14,16,22H,8-13,15H2,1H3
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382702
PNG
(US10273259, Example 411)
Show SMILES OC(=O)C12CC(C1)(C2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H23F8NO5S/c29-17-3-5-18(6-4-17)43(41,42)25-9-10-37(21(38)23-12-24(13-23,14-23)22(39)40)20(25)8-1-15-11-16(2-7-19(15)25)26(30,27(31,32)33)28(34,35)36/h2-7,11,20H,1,8-10,12-14H2,(H,39,40)/t20-,23?,24?,25-/m1/s1
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382373
PNG
(US10273259, Example 85)
Show SMILES CC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C27H26F7NO6S2/c1-23(10-13-42(37,38)14-11-23)22(36)35-12-9-24(43(39,40)18-5-3-2-4-6-18)19-8-7-17(15-20(19)41-16-21(24)35)25(28,26(29,30)31)27(32,33)34/h2-8,15,21H,9-14,16H2,1H3
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382555
PNG
(US10273259, Example 264)
Show SMILES CC(C)(CC(O)=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1
Show InChI InChI=1S/C27H25F8NO5S/c1-23(2,14-21(37)38)22(39)36-11-10-24(42(40,41)18-5-3-4-17(28)13-18)19-8-7-16(12-15(19)6-9-20(24)36)25(29,26(30,31)32)27(33,34)35/h3-5,7-8,12-13,20H,6,9-11,14H2,1-2H3,(H,37,38)
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382956
PNG
(US10273259, Example 667)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)NCC1CCS(=O)(=O)C1
Show InChI InChI=1S/C27H26F8N2O5S2/c28-19-3-5-20(6-4-19)44(41,42)24-10-11-37(23(38)36-14-16-9-12-43(39,40)15-16)22(24)8-1-17-13-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,13,16,22H,1,8-12,14-15H2,(H,36,38)/t16?,22-,24-/m1/s1
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382764
PNG
(US10273259, Example 473)
Show SMILES CC(C)(C)[C@H](O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C27H27F8NO4S/c1-23(2,3)21(37)22(38)36-13-12-24(41(39,40)18-8-6-17(28)7-9-18)19-10-5-16(14-15(19)4-11-20(24)36)25(29,26(30,31)32)27(33,34)35/h5-10,14,20-21,37H,4,11-13H2,1-3H3/t20-,21-,24-/m1/s1
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382806
PNG
(US10273259, Example 517)
Show SMILES Fc1cccc(c1)S(=O)(=O)C12CCN(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1
Show InChI InChI=1S/C26H24F8N2O5S2/c27-17-2-1-3-18(13-17)43(40,41)23-8-9-36(22(37)15-6-10-42(38,39)11-7-15)21(23)14-35-20-12-16(4-5-19(20)23)24(28,25(29,30)31)26(32,33)34/h1-5,12-13,15,21,35H,6-11,14H2
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382802
PNG
(US10273259, Example 513 | US10273259, Example 522)
Show SMILES CN1[C@@H](C[C@H](F)C1=O)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1
Show InChI InChI=1S/C26H22F9N3O4S/c1-37-19(11-17(28)21(37)39)22(40)38-8-7-23(43(41,42)15-4-2-3-14(27)10-15)16-6-5-13(9-18(16)36-12-20(23)38)24(29,25(30,31)32)26(33,34)35/h2-6,9-10,17,19-20,36H,7-8,11-12H2,1H3/t17-,19-,20?,23?/m0/s1
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM383110
PNG
((2-amino-5-methyl-2-oxido-1,3,2-dioxaphosphinan-5-...)
Show SMILES CC1(COP(N)(=O)OC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C26H25F8N2O6PS/c1-22(13-41-43(35,38)42-14-22)21(37)36-11-10-23(44(39,40)18-6-4-17(27)5-7-18)19-8-3-16(12-15(19)2-9-20(23)36)24(28,25(29,30)31)26(32,33)34/h3-8,12,20H,2,9-11,13-14H2,1H3,(H2,35,38)/t20-,22?,23-,43?/m1/s1
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM383104
PNG
(US10273259, Example 815)
Show SMILES OC1(CCN(CC1)C1COC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C30H30F8N2O5S/c31-20-3-5-22(6-4-20)46(43,44)27-11-14-40(25(41)26(42)9-12-39(13-10-26)21-16-45-17-21)24(27)8-1-18-15-19(2-7-23(18)27)28(32,29(33,34)35)30(36,37)38/h2-7,15,21,24,42H,1,8-14,16-17H2/t24-,27-/m1/s1
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382361
PNG
(US10273259, Example 74)
Show SMILES OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1CCc1cc(C=[F]C(F)(F)F)ccc21)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C30H30F5NO5S/c31-21-3-5-22(6-4-21)42(40,41)29-15-16-36(25(37)27-9-12-28(13-10-27,14-11-27)26(38)39)24(29)8-2-20-17-19(1-7-23(20)29)18-35-30(32,33)34/h1,3-7,17-18,24H,2,8-16H2,(H,38,39)
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382768
PNG
(US10273259, Example 477)
Show SMILES CCNS(=O)(=O)CCC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C26H26F8N2O5S2/c1-2-35-42(38,39)14-11-22(37)36-13-12-23(43(40,41)19-7-5-18(27)6-8-19)20-9-4-17(15-16(20)3-10-21(23)36)24(28,25(29,30)31)26(32,33)34/h4-9,15,21,35H,2-3,10-14H2,1H3/t21-,23-/m1/s1
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382367
PNG
(US10273259, Example 80)
Show SMILES OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H27F6NO5S/c29-20-7-9-21(10-8-20)41(39,40)26-13-14-35(24(36)16-1-3-17(4-2-16)25(37)38)23(26)12-5-18-15-19(6-11-22(18)26)27(30,31)28(32,33)34/h6-11,15-17,23H,1-5,12-14H2,(H,37,38)/t16-,17-,23?,26?
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382591
PNG
(US10273259, Example 300)
Show SMILES OC(=O)CN1[C@@H](CCC1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H24F8N2O6S/c29-17-3-5-18(6-4-17)45(43,44)25-11-12-37(24(42)20-8-10-22(39)38(20)14-23(40)41)21(25)9-1-15-13-16(2-7-19(15)25)26(30,27(31,32)33)28(34,35)36/h2-7,13,20-21H,1,8-12,14H2,(H,40,41)/t20-,21+,25+/m0/s1
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382734
PNG
(US10273259, Example 443 | US10273259, Example 475)
Show SMILES CC(C)(C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(F)(F)F
Show InChI InChI=1S/C26H22F11NO3S/c1-21(2,24(29,30)31)20(39)38-12-11-22(42(40,41)17-7-5-16(27)6-8-17)18-9-4-15(13-14(18)3-10-19(22)38)23(28,25(32,33)34)26(35,36)37/h4-9,13,19H,3,10-12H2,1-2H3/t19-,22-/m1/s1
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382988
PNG
(US10273259, Example 699)
Show SMILES CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@@]1(C)CC[C@@H](CC1)C(O)=O
Show InChI InChI=1S/C30H30F8N2O5S/c1-26(11-9-17(10-12-26)24(41)42)25(43)40-14-13-27(46(44,45)20-6-4-19(31)5-7-20)21-8-3-18(15-22(21)39(2)16-23(27)40)28(32,29(33,34)35)30(36,37)38/h3-8,15,17,23H,9-14,16H2,1-2H3,(H,41,42)/t17-,23?,26-,27?
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382380
PNG
(US10273259, Example 92 | US10273259, Example 94)
Show SMILES CN1[C@@H](CCC1=O)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C26H23F7N2O5S/c1-34-18(9-10-21(34)36)22(37)35-12-11-23(41(38,39)16-5-3-2-4-6-16)17-8-7-15(13-19(17)40-14-20(23)35)24(27,25(28,29)30)26(31,32)33/h2-8,13,18,20H,9-12,14H2,1H3/t18-,20?,23?/m0/s1
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Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382705
PNG
(US10273259, Example 414)
Show SMILES CS(=O)(=O)N1CCC(CO)(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C29H30F8N2O6S2/c1-46(42,43)38-13-10-25(17-40,11-14-38)24(41)39-15-12-26(47(44,45)21-6-4-20(30)5-7-21)22-8-3-19(16-18(22)2-9-23(26)39)27(31,28(32,33)34)29(35,36)37/h3-8,16,23,40H,2,9-15,17H2,1H3/t23-,26-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382481
PNG
(US10273259, Example 190)
Show SMILES CC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H27ClF7NO5S2/c1-24(11-14-43(39,40)15-12-24)23(38)37-13-10-25(44(41,42)20-6-4-19(29)5-7-20)21-8-3-18(16-17(21)2-9-22(25)37)26(30,27(31,32)33)28(34,35)36/h3-8,16,22H,2,9-15H2,1H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382791
PNG
(US10273259, Example 502)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc2cncn2c1
Show InChI InChI=1S/C29H21F8N3O3S/c30-20-4-7-22(8-5-20)44(42,43)26-11-12-40(25(41)18-1-6-21-14-38-16-39(21)15-18)24(26)10-2-17-13-19(3-9-23(17)26)27(31,28(32,33)34)29(35,36)37/h1,3-9,13-16,24H,2,10-12H2/t24-,26-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382655
PNG
(US10273259, Example 364)
Show SMILES CC(=O)N1CC(C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C27H24F8N2O4S/c1-15(38)36-13-17(14-36)23(39)37-11-10-24(42(40,41)20-6-4-19(28)5-7-20)21-8-3-18(12-16(21)2-9-22(24)37)25(29,26(30,31)32)27(33,34)35/h3-8,12,17,22H,2,9-11,13-14H2,1H3/t22-,24-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382698
PNG
(US10273259, Example 407)
Show SMILES Cc1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O
Show InChI InChI=1S/C30H28F9NO5S/c1-16-14-20(4-6-22(16)31)46(44,45)27-12-13-40(25(43)26(32)10-8-17(9-11-26)24(41)42)23(27)7-2-18-15-19(3-5-21(18)27)28(33,29(34,35)36)30(37,38)39/h3-6,14-15,17,23H,2,7-13H2,1H3,(H,41,42)/t17-,23?,26+,27?
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382476
PNG
(US10273259, Example 185)
Show SMILES FC(F)(F)c1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)C1
Show InChI InChI=1S/C27H23F10NO5S2/c28-24(26(32,33)34,27(35,36)37)18-4-7-20-15(13-18)1-8-21-23(20,10-11-38(21)22(39)16-9-12-44(40,41)14-16)45(42,43)19-5-2-17(3-6-19)25(29,30)31/h2-7,13,16,21H,1,8-12,14H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382345
PNG
(US10273259, Example 63)
Show SMILES OC(=O)[C@H]1CC[C@@](O)(CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H27ClF7NO6S/c30-19-3-5-20(6-4-19)45(43,44)26-13-14-38(24(41)25(42)11-9-16(10-12-25)23(39)40)22(26)8-1-17-15-18(2-7-21(17)26)27(31,28(32,33)34)29(35,36)37/h2-7,15-16,22,42H,1,8-14H2,(H,39,40)/t16-,22?,25+,26?
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382760
PNG
(US10273259, Example 469)
Show SMILES OC(C1CCOCC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H27F8NO5S/c29-19-3-5-20(6-4-19)43(40,41)25-11-12-37(24(39)23(38)16-9-13-42-14-10-16)22(25)8-1-17-15-18(2-7-21(17)25)26(30,27(31,32)33)28(34,35)36/h2-7,15-16,22-23,38H,1,8-14H2/t22-,23?,25-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382483
PNG
(US10273259, Example 192 | US10273259, Example 193)
Show SMILES FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)C2CCS(=O)(=O)C2)c1)C(F)(F)F
Show InChI InChI=1S/C26H23ClF7NO5S2/c27-18-3-5-19(6-4-18)42(39,40)23-10-11-35(22(36)16-9-12-41(37,38)14-16)21(23)8-1-15-13-17(2-7-20(15)23)24(28,25(29,30)31)26(32,33)34/h2-7,13,16,21H,1,8-12,14H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382483
PNG
(US10273259, Example 192 | US10273259, Example 193)
Show SMILES FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)C2CCS(=O)(=O)C2)c1)C(F)(F)F
Show InChI InChI=1S/C26H23ClF7NO5S2/c27-18-3-5-19(6-4-18)42(39,40)23-10-11-35(22(36)16-9-12-41(37,38)14-16)21(23)8-1-15-13-17(2-7-20(15)23)24(28,25(29,30)31)26(32,33)34/h2-7,13,16,21H,1,8-12,14H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382759
PNG
(US10273259, Example 468)
Show SMILES OC1(CCCCC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H27F8NO4S/c29-19-6-8-20(9-7-19)42(40,41)25-14-15-37(23(38)24(39)12-2-1-3-13-24)22(25)11-4-17-16-18(5-10-21(17)25)26(30,27(31,32)33)28(34,35)36/h5-10,16,22,39H,1-4,11-15H2/t22-,25-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382934
PNG
(US10273259, Example 645)
Show SMILES Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)NC1CCOCC1
Show InChI InChI=1S/C27H26F8N2O4S/c28-18-3-5-20(6-4-18)42(39,40)24-11-12-37(23(38)36-19-9-13-41-14-10-19)22(24)8-1-16-15-17(2-7-21(16)24)25(29,26(30,31)32)27(33,34)35/h2-7,15,19,22H,1,8-14H2,(H,36,38)/t22-,24-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Mus musculus)
BDBM382801
PNG
(US10273259, Example 512)
Show SMILES C[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C29H28F8N2O5S/c1-25(10-8-16(9-11-25)23(40)41)24(42)39-13-12-26(45(43,44)19-5-3-18(30)4-6-19)20-7-2-17(14-21(20)38-15-22(26)39)27(31,28(32,33)34)29(35,36)37/h2-7,14,16,22,38H,8-13,15H2,1H3,(H,40,41)/t16-,22?,25-,26?
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Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...


US Patent US10273259 (2019)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%