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Patent code US10280149

Compile Data Set for Download or QSAR

Found 220 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383693
PNG
(2-(6-(1-cyclobutyl-4-methylpiperidine-3-carbonyl)-...)
Show SMILES COc1ccc2cc(ccc2c1CC#N)C(=O)[C@@H]1CN(CC[C@@H]1C)C1CCC1
Show InChI InChI=1S/C24H28N2O2/c1-16-11-13-26(19-4-3-5-19)15-22(16)24(27)18-6-8-20-17(14-18)7-9-23(28-2)21(20)10-12-25/h6-9,14,16,19,22H,3-5,10-11,13,15H2,1-2H3/t16-,22+/m0/s1
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US Patent
n/an/a 1.12n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383699
PNG
(US10280149, Example 184b)
Show SMILES CCC[C@H]1CCN(C[C@H]1C(=O)c1ccc2c(CC#N)c(OC)ccc2c1)C1CCC1
Show InChI InChI=1S/C26H32N2O2/c1-3-5-18-13-15-28(21-6-4-7-21)17-24(18)26(29)20-8-10-22-19(16-20)9-11-25(30-2)23(22)12-14-27/h8-11,16,18,21,24H,3-7,12-13,15,17H2,1-2H3/t18-,24+/m0/s1
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US Patent
n/an/a 1.41n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383697
PNG
(US10280149, Example 183d)
Show SMILES CC[C@H]1CCN(C[C@H]1C(=O)c1ccc2c(CC#N)c(OC)ccc2c1)C1CCC1
Show InChI InChI=1S/C25H30N2O2/c1-3-17-12-14-27(20-5-4-6-20)16-23(17)25(28)19-7-9-21-18(15-19)8-10-24(29-2)22(21)11-13-26/h7-10,15,17,20,23H,3-6,11-12,14,16H2,1-2H3/t17-,23+/m0/s1
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US Patent
n/an/a 1.53n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383703
PNG
(2-(6-(1-cyclobutyl-4-isobutylpiperidine-3-carbonyl...)
Show SMILES COc1ccc2cc(ccc2c1CC#N)C(=O)[C@H]1CN(CC[C@H]1CC(C)C)C1CCC1
Show InChI InChI=1S/C27H34N2O2/c1-18(2)15-20-12-14-29(22-5-4-6-22)17-25(20)27(30)21-7-9-23-19(16-21)8-10-26(31-3)24(23)11-13-28/h7-10,16,18,20,22,25H,4-6,11-12,14-15,17H2,1-3H3/t20-,25-/m0/s1
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US Patent
n/an/a 2n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383695
PNG
(US10280149, Example 183b)
Show SMILES CC[C@H]1CCN(C[C@@H]1C(=O)c1ccc2c(CC#N)c(OC)ccc2c1)C1CCC1
Show InChI InChI=1S/C25H30N2O2/c1-3-17-12-14-27(20-5-4-6-20)16-23(17)25(28)19-7-9-21-18(15-19)8-10-24(29-2)22(21)11-13-26/h7-10,15,17,20,23H,3-6,11-12,14,16H2,1-2H3/t17-,23-/m0/s1
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US Patent
n/an/a 2.06n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383705
PNG
(2-(6-(1-cyclobutyl-4-isopropylpiperidine-3-carbony...)
Show SMILES COc1ccc2cc(ccc2c1CC#N)C(=O)[C@H]1CN(CC[C@H]1C(C)C)C1CCC1
Show InChI InChI=1S/C26H32N2O2/c1-17(2)21-12-14-28(20-5-4-6-20)16-24(21)26(29)19-7-9-22-18(15-19)8-10-25(30-3)23(22)11-13-27/h7-10,15,17,20-21,24H,4-6,11-12,14,16H2,1-3H3/t21-,24-/m0/s1
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US Patent
n/an/a 2.12n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383700
PNG
(US10280149, Example 184c)
Show SMILES CCC[C@@H]1CCN(C[C@H]1C(=O)c1ccc2c(CC#N)c(OC)ccc2c1)C1CCC1
Show InChI InChI=1S/C26H32N2O2/c1-3-5-18-13-15-28(21-6-4-7-21)17-24(18)26(29)20-8-10-22-19(16-20)9-11-25(30-2)23(22)12-14-27/h8-11,16,18,21,24H,3-7,12-13,15,17H2,1-2H3/t18-,24-/m1/s1
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US Patent
n/an/a 3.13n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383650
PNG
((1-cyclopropyl-4-ethylpiperidin-3-yl)(6-methoxynap...)
Show SMILES CC[C@H]1CCN(C[C@H]1C(=O)c1ccc2cc(OC)ccc2c1)C1CC1
Show InChI InChI=1S/C22H27NO2/c1-3-15-10-11-23(19-7-8-19)14-21(15)22(24)18-5-4-17-13-20(25-2)9-6-16(17)12-18/h4-6,9,12-13,15,19,21H,3,7-8,10-11,14H2,1-2H3/t15-,21+/m0/s1
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US Patent
n/an/a 4.90n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383634
PNG
(US10280149, Example 140c)
Show SMILES CCC[C@H]1CCN(C[C@H]1C(=O)c1ccc2cc(OC)ccc2c1)C1CCC1
Show InChI InChI=1S/C24H31NO2/c1-3-5-17-12-13-25(21-6-4-7-21)16-23(17)24(26)20-9-8-19-15-22(27-2)11-10-18(19)14-20/h8-11,14-15,17,21,23H,3-7,12-13,16H2,1-2H3/t17-,23+/m0/s1
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US Patent
n/an/a 5.48n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383644
PNG
((1-cyclobutyl-4-isobutylpiperidin-3-yl)(6-methoxyn...)
Show SMILES COc1ccc2cc(ccc2c1)C(=O)[C@@H]1CN(CC[C@@H]1CC(C)C)C1CCC1
Show InChI InChI=1S/C25H33NO2/c1-17(2)13-20-11-12-26(22-5-4-6-22)16-24(20)25(27)21-8-7-19-15-23(28-3)10-9-18(19)14-21/h7-10,14-15,17,20,22,24H,4-6,11-13,16H2,1-3H3/t20-,24-/m1/s1
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n/an/a 5.60n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383688
PNG
(2-(6-(1-cyclobutylpiperidine-3-carbonyl)-2-methoxy...)
Show SMILES COc1ccc2cc(ccc2c1CC#N)C(=O)[C@H]1CCCN(C1)C1CCC1
Show InChI InChI=1S/C23H26N2O2/c1-27-22-10-8-16-14-17(7-9-20(16)21(22)11-12-24)23(26)18-4-3-13-25(15-18)19-5-2-6-19/h7-10,14,18-19H,2-6,11,13,15H2,1H3/t18-/m0/s1
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US Patent
n/an/a 5.65n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383641
PNG
(US10280149, Example 142d)
Show SMILES CC[C@H]1CCN(C[C@H]1C(=O)c1ccc2cc(OC)ccc2c1)C1CCC1
Show InChI InChI=1S/C23H29NO2/c1-3-16-11-12-24(20-5-4-6-20)15-22(16)23(25)19-8-7-18-14-21(26-2)10-9-17(18)13-19/h7-10,13-14,16,20,22H,3-6,11-12,15H2,1-2H3/t16-,22+/m0/s1
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n/an/a 6.56n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383635
PNG
(US10280149, Example 140d)
Show SMILES CCC[C@@H]1CCN(C[C@H]1C(=O)c1ccc2cc(OC)ccc2c1)C1CCC1
Show InChI InChI=1S/C24H31NO2/c1-3-5-17-12-13-25(21-6-4-7-21)16-23(17)24(26)20-9-8-19-15-22(27-2)11-10-18(19)14-20/h8-11,14-15,17,21,23H,3-7,12-13,16H2,1-2H3/t17-,23-/m1/s1
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n/an/a 9.96n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383638
PNG
(US10280149, Example 142a)
Show SMILES CC[C@@H]1CCN(C[C@H]1C(=O)c1ccc2cc(OC)ccc2c1)C1CCC1
Show InChI InChI=1S/C23H29NO2/c1-3-16-11-12-24(20-5-4-6-20)15-22(16)23(25)19-8-7-18-14-21(26-2)10-9-17(18)13-19/h7-10,13-14,16,20,22H,3-6,11-12,15H2,1-2H3/t16-,22-/m1/s1
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n/an/a 11.4n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383691
PNG
(2-(2-methoxy-6-(4-methyl-1-propylpiperidine-3-carb...)
Show SMILES CCCN1CC[C@H](C)[C@@H](C1)C(=O)c1ccc2c(CC#N)c(OC)ccc2c1
Show InChI InChI=1S/C23H28N2O2/c1-4-12-25-13-10-16(2)21(15-25)23(26)18-5-7-19-17(14-18)6-8-22(27-3)20(19)9-11-24/h5-8,14,16,21H,4,9-10,12-13,15H2,1-3H3/t16-,21+/m0/s1
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n/an/a 12.3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383668
PNG
(6-(1-cyclobutyl-4-methylpiperidine-3-carbonyl)-2-n...)
Show SMILES C[C@@H]1CCN(C[C@H]1C(=O)c1ccc2cc(ccc2c1)C#N)C1CCC1
Show InChI InChI=1S/C22H24N2O/c1-15-9-10-24(20-3-2-4-20)14-21(15)22(25)19-8-7-17-11-16(13-23)5-6-18(17)12-19/h5-8,11-12,15,20-21H,2-4,9-10,14H2,1H3/t15-,21-/m1/s1
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n/an/a 12.3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383546
PNG
(2-[6-(1-cyclobutylpiperidine-3-carbonyl)-2-methoxy...)
Show SMILES COc1ccc2cc(ccc2c1CC#N)C(=O)C1CCCN(C1)C1CCC1
Show InChI InChI=1S/C23H26N2O2/c1-27-22-10-8-16-14-17(7-9-20(16)21(22)11-12-24)23(26)18-4-3-13-25(15-18)19-5-2-6-19/h7-10,14,18-19H,2-6,11,13,15H2,1H3
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n/an/a 13.2n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383643
PNG
(US10280149, Example 143b)
Show SMILES COc1ccc2cc(ccc2c1)C(=O)[C@H]1CN(CC[C@H]1C(C)C)C1CCC1
Show InChI InChI=1S/C24H31NO2/c1-16(2)22-11-12-25(20-5-4-6-20)15-23(22)24(26)19-8-7-18-14-21(27-3)10-9-17(18)13-19/h7-10,13-14,16,20,22-23H,4-6,11-12,15H2,1-3H3/t22-,23-/m0/s1
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n/an/a 15.9n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383711
PNG
(3-[[4-cyclobutyl-2-(6-methoxynaphthalene-2-carbony...)
Show SMILES COc1ccc2cc(ccc2c1)C(=O)C1CN(CCN1Cc1cccc(c1)C#N)C1CCC1
Show InChI InChI=1S/C28H29N3O2/c1-33-26-11-10-22-15-24(9-8-23(22)16-26)28(32)27-19-30(25-6-3-7-25)12-13-31(27)18-21-5-2-4-20(14-21)17-29/h2,4-5,8-11,14-16,25,27H,3,6-7,12-13,18-19H2,1H3
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n/an/a 22.3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383541
PNG
((6-methoxy-5-methyl-2-naphthyl)-(1-propyl-3-piperi...)
Show SMILES CCCN1CCCC(C1)C(=O)c1ccc2c(C)c(OC)ccc2c1
Show InChI InChI=1S/C21H27NO2/c1-4-11-22-12-5-6-18(14-22)21(23)17-7-9-19-15(2)20(24-3)10-8-16(19)13-17/h7-10,13,18H,4-6,11-12,14H2,1-3H3
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n/an/a 26n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383717
PNG
(4-[[4-cyclobutyl-2-(6-methoxynaphthalene-2-carbony...)
Show SMILES COc1ccc2cc(ccc2c1)C(=O)C1CN(CCN1Cc1ccc(cc1)C#N)C1CCC1
Show InChI InChI=1S/C28H29N3O2/c1-33-26-12-11-22-15-24(10-9-23(22)16-26)28(32)27-19-30(25-3-2-4-25)13-14-31(27)18-21-7-5-20(17-29)6-8-21/h5-12,15-16,25,27H,2-4,13-14,18-19H2,1H3
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US Patent
n/an/a 30.9n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383544
PNG
(2-[6-[1-(cyclopropylmethyl)piperidine-3-carbonyl]-...)
Show SMILES COc1ccc2cc(ccc2c1CC#N)C(=O)C1CCCN(CC2CC2)C1
Show InChI InChI=1S/C23H26N2O2/c1-27-22-9-7-17-13-18(6-8-20(17)21(22)10-11-24)23(26)19-3-2-12-25(15-19)14-16-4-5-16/h6-9,13,16,19H,2-5,10,12,14-15H2,1H3
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n/an/a 33.5n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383543
PNG
((1-cyclobutyl-3-piperidyl)-(6-methoxy-5-methyl-2-n...)
Show SMILES COc1ccc2cc(ccc2c1C)C(=O)C1CCCN(C1)C1CCC1
Show InChI InChI=1S/C22H27NO2/c1-15-20-10-8-17(13-16(20)9-11-21(15)25-2)22(24)18-5-4-12-23(14-18)19-6-3-7-19/h8-11,13,18-19H,3-7,12,14H2,1-2H3
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n/an/a 39.4n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383654
PNG
((1-(cyclopropylmethyl)-4-methylpiperidin-3-yl)(5-h...)
Show SMILES C[C@H]1CCN(CC2CC2)C[C@H]1C(=O)c1ccc2c(O)cccc2c1
Show InChI InChI=1S/C21H25NO2/c1-14-9-10-22(12-15-5-6-15)13-19(14)21(24)17-7-8-18-16(11-17)3-2-4-20(18)23/h2-4,7-8,11,14-15,19,23H,5-6,9-10,12-13H2,1H3/t14-,19+/m0/s1
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n/an/a 39.5n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383545
PNG
(2-[6-(1-cyclopentylpiperidine-3-carbonyl)-2-methox...)
Show SMILES COc1ccc2cc(ccc2c1CC#N)C(=O)C1CCCN(C1)C1CCCC1
Show InChI InChI=1S/C24H28N2O2/c1-28-23-11-9-17-15-18(8-10-21(17)22(23)12-13-25)24(27)19-5-4-14-26(16-19)20-6-2-3-7-20/h8-11,15,19-20H,2-7,12,14,16H2,1H3
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n/an/a 39.5n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383622
PNG
((1-(cyclopropylmethyl)-4-methylpiperidin-3-yl)(5-m...)
Show SMILES COc1cccc2cc(ccc12)C(=O)[C@H]1CN(CC2CC2)CC[C@H]1C
Show InChI InChI=1S/C22H27NO2/c1-15-10-11-23(13-16-6-7-16)14-20(15)22(24)18-8-9-19-17(12-18)4-3-5-21(19)25-2/h3-5,8-9,12,15-16,20H,6-7,10-11,13-14H2,1-2H3/t15-,20+/m1/s1
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n/an/a 41.4n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383679
PNG
((1-cyclobutylpiperidin-3-yl)(6-(methylsulfonyl)nap...)
Show SMILES CS(=O)(=O)c1ccc2cc(ccc2c1)C(=O)C1CCCN(C1)C1CCC1
Show InChI InChI=1S/C21H25NO3S/c1-26(24,25)20-10-9-15-12-17(8-7-16(15)13-20)21(23)18-4-3-11-22(14-18)19-5-2-6-19/h7-10,12-13,18-19H,2-6,11,14H2,1H3
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n/an/a 42.6n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383555
PNG
((1-cyclobutyl-3-piperidyl)-[4-(1-hydroxyethyl)-2-n...)
Show SMILES CC(O)c1cc(cc2ccccc12)C(=O)C1CCCN(C1)C1CCC1
Show InChI InChI=1S/C22H27NO2/c1-15(24)21-13-18(12-16-6-2-3-10-20(16)21)22(25)17-7-5-11-23(14-17)19-8-4-9-19/h2-3,6,10,12-13,15,17,19,24H,4-5,7-9,11,14H2,1H3
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n/an/a 43.8n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383672
PNG
(6-(4-methyl-1-propylpiperidine-3-carbonyl)-2-napht...)
Show SMILES CCCN1CC[C@@H](C)[C@@H](C1)C(=O)c1ccc2cc(ccc2c1)C#N
Show InChI InChI=1S/C21H24N2O/c1-3-9-23-10-8-15(2)20(14-23)21(24)19-7-6-17-11-16(13-22)4-5-18(17)12-19/h4-7,11-12,15,20H,3,8-10,14H2,1-2H3/t15-,20-/m1/s1
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n/an/a 45.4n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383549
PNG
((1-cyclobutyl-3-piperidyl)-[4-(hydroxymethyl)-2-na...)
Show SMILES OCc1cc(cc2ccccc12)C(=O)C1CCCN(C1)C1CCC1
Show InChI InChI=1S/C21H25NO2/c23-14-18-12-17(11-15-5-1-2-9-20(15)18)21(24)16-6-4-10-22(13-16)19-7-3-8-19/h1-2,5,9,11-12,16,19,23H,3-4,6-8,10,13-14H2
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n/an/a 47.6n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383702
PNG
(2-(6-(1-cyclobutyl-4-isobutylpiperidine-3-carbonyl...)
Show SMILES COc1ccc2cc(ccc2c1CC#N)C(=O)[C@@H]1CN(CC[C@@H]1CC(C)C)C1CCC1
Show InChI InChI=1S/C27H34N2O2/c1-18(2)15-20-12-14-29(22-5-4-6-22)17-25(20)27(30)21-7-9-23-19(16-21)8-10-26(31-3)24(23)11-13-28/h7-10,16,18,20,22,25H,4-6,11-12,14-15,17H2,1-3H3/t20-,25-/m1/s1
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n/an/a 53.5n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383694
PNG
(US10280149, Example 183a)
Show SMILES CC[C@@H]1CCN(C[C@H]1C(=O)c1ccc2c(CC#N)c(OC)ccc2c1)C1CCC1
Show InChI InChI=1S/C25H30N2O2/c1-3-17-12-14-27(20-5-4-6-20)16-23(17)25(28)19-7-9-21-18(15-19)8-10-24(29-2)22(21)11-13-26/h7-10,15,17,20,23H,3-6,11-12,14,16H2,1-2H3/t17-,23-/m1/s1
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n/an/a 55.2n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383707
PNG
((1-cyclobutylpiperidin-3-yl)(5-(hydroxymethyl)-6-m...)
Show SMILES COc1ccc2cc(ccc2c1CO)C(=O)C1CCCN(C1)C1CCC1
Show InChI InChI=1S/C22H27NO3/c1-26-21-10-8-15-12-16(7-9-19(15)20(21)14-24)22(25)17-4-3-11-23(13-17)18-5-2-6-18/h7-10,12,17-18,24H,2-6,11,13-14H2,1H3
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n/an/a 55.3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383619
PNG
((1-cyclobutylpiperidin-3-yl)(6,7,8,9-tetrahydro-5H...)
Show SMILES O=C(C1CCCN(C1)C1CCC1)c1ccc2CCCCCc2c1
Show InChI InChI=1S/C21H29NO/c23-21(19-8-5-13-22(15-19)20-9-4-10-20)18-12-11-16-6-2-1-3-7-17(16)14-18/h11-12,14,19-20H,1-10,13,15H2
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n/an/a 55.3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383505
PNG
(US10280149, Example 10 | [(3S)-1-cyclopentyl-3-pip...)
Show SMILES COc1ccc2cc(ccc2c1)C(=O)[C@H]1CCCN(C1)C1CCCC1
Show InChI InChI=1S/C22H27NO2/c1-25-21-11-10-16-13-18(9-8-17(16)14-21)22(24)19-5-4-12-23(15-19)20-6-2-3-7-20/h8-11,13-14,19-20H,2-7,12,15H2,1H3/t19-/m0/s1
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n/an/a 56.6n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383557
PNG
(US10280149, Example 66 | [1-(3,3-difluorocyclobuty...)
Show SMILES COc1ccc2cc(ccc2c1)C(=O)C1CCCN(C1)C1CC(F)(F)C1
Show InChI InChI=1S/C21H23F2NO2/c1-26-19-7-6-14-9-16(5-4-15(14)10-19)20(25)17-3-2-8-24(13-17)18-11-21(22,23)12-18/h4-7,9-10,17-18H,2-3,8,11-13H2,1H3
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n/an/a 67.5n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383664
PNG
(6-(1-(cyclopropylmethyl)piperidine-3-carbonyl)-2-n...)
Show SMILES O=C(C1CCCN(CC2CC2)C1)c1ccc2cc(ccc2c1)C#N
Show InChI InChI=1S/C21H22N2O/c22-12-16-5-6-18-11-19(8-7-17(18)10-16)21(24)20-2-1-9-23(14-20)13-15-3-4-15/h5-8,10-11,15,20H,1-4,9,13-14H2
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n/an/a 68.8n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383704
PNG
(2-(6-(1-cyclobutyl-4-isopropylpiperidine-3-carbony...)
Show SMILES COc1ccc2cc(ccc2c1CC#N)C(=O)[C@@H]1CN(CC[C@@H]1C(C)C)C1CCC1
Show InChI InChI=1S/C26H32N2O2/c1-17(2)21-12-14-28(20-5-4-6-20)16-24(21)26(29)19-7-9-22-18(15-19)8-10-25(30-3)23(22)11-13-27/h7-10,15,17,20-21,24H,4-6,11-12,14,16H2,1-3H3/t21-,24-/m1/s1
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n/an/a 70.1n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383624
PNG
(US10280149, Example 137a)
Show SMILES COc1ccc2cc(ccc2c1)C(=O)[C@@H]1CC(CC[C@@H]1C)NC1CC1
Show InChI InChI=1S/C22H27NO2/c1-14-3-7-19(23-18-8-9-18)13-21(14)22(24)17-5-4-16-12-20(25-2)10-6-15(16)11-17/h4-6,10-12,14,18-19,21,23H,3,7-9,13H2,1-2H3/t14-,19?,21+/m0/s1
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n/an/a 70.6n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383559
PNG
(US10280149, Example 68 | [4-(1-hydroxyethyl)-2-nap...)
Show SMILES CCCN1CCCC(C1)C(=O)c1cc(C(C)O)c2ccccc2c1
Show InChI InChI=1S/C21H27NO2/c1-3-10-22-11-6-8-17(14-22)21(24)18-12-16-7-4-5-9-19(16)20(13-18)15(2)23/h4-5,7,9,12-13,15,17,23H,3,6,8,10-11,14H2,1-2H3
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n/an/a 76.2n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383698
PNG
(US10280149, Example 184a)
Show SMILES CCC[C@@H]1CCN(C[C@@H]1C(=O)c1ccc2c(CC#N)c(OC)ccc2c1)C1CCC1
Show InChI InChI=1S/C26H32N2O2/c1-3-5-18-13-15-28(21-6-4-7-21)17-24(18)26(29)20-8-10-22-19(16-20)9-11-25(30-2)23(22)12-14-27/h8-11,16,18,21,24H,3-7,12-13,15,17H2,1-2H3/t18-,24+/m1/s1
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n/an/a 77.4n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383696
PNG
(US10280149, Example 183c)
Show SMILES CC[C@@H]1CCN(C[C@@H]1C(=O)c1ccc2c(CC#N)c(OC)ccc2c1)C1CCC1
Show InChI InChI=1S/C25H30N2O2/c1-3-17-12-14-27(20-5-4-6-20)16-23(17)25(28)19-7-9-21-18(15-19)8-10-24(29-2)22(21)11-13-26/h7-10,15,17,20,23H,3-6,11-12,14,16H2,1-2H3/t17-,23+/m1/s1
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n/an/a 78n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383670
PNG
(6-(1-cyclopentyl-4-methylpiperidine-3-carbonyl)-2-...)
Show SMILES C[C@@H]1CCN(C[C@H]1C(=O)c1ccc2cc(ccc2c1)C#N)C1CCCC1
Show InChI InChI=1S/C23H26N2O/c1-16-10-11-25(21-4-2-3-5-21)15-22(16)23(26)20-9-8-18-12-17(14-24)6-7-19(18)13-20/h6-9,12-13,16,21-22H,2-5,10-11,15H2,1H3/t16-,22-/m1/s1
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n/an/a 85.7n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383563
PNG
(6-(1-cyclobutylpiperidine-3-carbonyl)-1-methyl-2-n...)
Show SMILES Cc1c(ccc2cc(ccc12)C(=O)C1CCCN(C1)C1CCC1)C#N
Show InChI InChI=1S/C22H24N2O/c1-15-18(13-23)8-7-16-12-17(9-10-21(15)16)22(25)19-4-3-11-24(14-19)20-5-2-6-20/h7-10,12,19-20H,2-6,11,14H2,1H3
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n/an/a 87.5n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383609
PNG
((5-(benzyloxy)naphthalen-2-yl)(1-(cyclopropylmethy...)
Show SMILES O=C(C1CCCN(CC2CC2)C1)c1ccc2c(OCc3ccccc3)cccc2c1
Show InChI InChI=1S/C27H29NO2/c29-27(24-9-5-15-28(18-24)17-20-11-12-20)23-13-14-25-22(16-23)8-4-10-26(25)30-19-21-6-2-1-3-7-21/h1-4,6-8,10,13-14,16,20,24H,5,9,11-12,15,17-19H2
PDB

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UniChem
US Patent
n/an/a 90.9n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383561
PNG
(1-methyl-6-(1-propylpiperidine-3-carbonyl)-2-napht...)
Show SMILES CCCN1CCCC(C1)C(=O)c1ccc2c(C)c(ccc2c1)C#N
Show InChI InChI=1S/C21H24N2O/c1-3-10-23-11-4-5-19(14-23)21(24)17-8-9-20-15(2)18(13-22)7-6-16(20)12-17/h6-9,12,19H,3-5,10-11,14H2,1-2H3
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UniChem
US Patent
n/an/a 91.8n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383625
PNG
(US10280149, Example 137b)
Show SMILES COc1ccc2cc(ccc2c1)C(=O)[C@@H]1CN(CC2CC2)CC[C@H]1C
Show InChI InChI=1S/C22H27NO2/c1-15-9-10-23(13-16-3-4-16)14-21(15)22(24)19-6-5-18-12-20(25-2)8-7-17(18)11-19/h5-8,11-12,15-16,21H,3-4,9-10,13-14H2,1-2H3/t15-,21-/m1/s1
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US Patent
n/an/a 92.8n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383524
PNG
(US10280149, Example 33 | [(3S)-1-(cyclopropylmethy...)
Show SMILES O=C([C@H]1CCCN(CC2CC2)C1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C22H25NO/c24-22(21-7-4-14-23(16-21)15-17-8-9-17)20-12-10-19(11-13-20)18-5-2-1-3-6-18/h1-3,5-6,10-13,17,21H,4,7-9,14-16H2/t21-/m0/s1
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UniChem
US Patent
n/an/a 95.4n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383637
PNG
((1-cyclobutyl-4-phenylpiperidin-3-yl)(6-methoxynap...)
Show SMILES COc1ccc2cc(ccc2c1)C(=O)[C@H]1CN(CC[C@H]1c1ccccc1)C1CCC1
Show InChI InChI=1S/C27H29NO2/c1-30-24-13-12-20-16-22(11-10-21(20)17-24)27(29)26-18-28(23-8-5-9-23)15-14-25(26)19-6-3-2-4-7-19/h2-4,6-7,10-13,16-17,23,25-26H,5,8-9,14-15,18H2,1H3/t25-,26-/m0/s1
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US Patent
n/an/a 98.7n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 2B


(Homo sapiens (Human))
BDBM383538
PNG
(3-(1-cyclobutylpiperidine-3-carbonyl)naphthalene-1...)
Show SMILES NC(=O)c1cc(cc2ccccc12)C(=O)C1CCCN(C1)C1CCC1
Show InChI InChI=1S/C21H24N2O2/c22-21(25)19-12-16(11-14-5-1-2-9-18(14)19)20(24)15-6-4-10-23(13-15)17-7-3-8-17/h1-2,5,9,11-12,15,17H,3-4,6-8,10,13H2,(H2,22,25)
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US Patent
n/an/a 99.7n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10280149 (2019)

More data for this
Ligand-Target Pair
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