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Patent code US10280150

Compile Data Set for Download or QSAR

Found 297 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
IDH1 R132H


(Homo sapiens (Human))
BDBM383879
PNG
(US10280150, Cmpd No I-162 | US10550099, Compound I...)
Show SMILES COc1nc(N[C@@H](C)c2cc3cc(Cl)c(Br)cc3[nH]c2=O)ncc1C#N
PDB

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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132C


(Homo sapiens (Human))
BDBM383890
PNG
(US10280150, Cmpd No I-173 | US10550099, Compound I...)
Show SMILES CC(C)n1cncc1-c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3n(C)c2=O)n1
Show InChI InChI=1S/C22H23ClN6O/c1-13(2)29-12-24-11-20(29)18-7-8-25-22(27-18)26-14(3)17-10-15-9-16(23)5-6-19(15)28(4)21(17)30/h5-14H,1-4H3,(H,25,26,27)/t14-/m0/s1
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132C


(Homo sapiens (Human))
BDBM383892
PNG
(US10280150, Cmpd No I-175 | US10550099, Compound I...)
Show SMILES COc1nc(N[C@@H](C)c2cc3cc(Cl)c(OC(C)C)cc3[nH]c2=O)ncc1C#N
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383893
PNG
(US10280150, Cmpd No I-176 | US10550099, Compound I...)
Show SMILES COc1nc(N[C@@H](C)c2cc3cc(Cl)c(cc3[nH]c2=O)C2CC2)ncc1C#N
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132C


(Homo sapiens (Human))
BDBM383896
PNG
(US10280150, Cmpd No I-179 | US10550099, Compound I...)
Show SMILES C[C@H](Nc1nccc(NC(C)=O)n1)c1cc2cc(Cl)c(F)cc2[nH]c1=O
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383899
PNG
(US10280150, Cmpd No I-182 | US10550099, Compound I...)
Show SMILES C[C@H](Nc1nccc(NC(C)=O)n1)c1cc2cc(Cl)cnc2[nH]c1=O
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132C


(Homo sapiens (Human))
BDBM383900
PNG
(US10280150, Cmpd No I-183 | US10550099, Compound I...)
Show SMILES C[C@H](Nc1nccc(n1)-n1nnnc1C1CC1)c1cc2cc(Cl)ccc2[nH]c1=O
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383728
PNG
(US10280150, Cmpd No I-11 | US10550099, Compound I-...)
Show SMILES CC(C)N(c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1)S(=O)(=O)CC1CC1
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383739
PNG
(US10280150, Cmpd No I-22 | US10550099, Compound I-...)
Show SMILES COC(=O)Nc1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383746
PNG
(US10280150, Cmpd No I-29 | US10550099, Compound I-...)
Show SMILES C[C@H](Nc1nccc(NC(=O)C2CC2)n1)c1cc2cc(Cl)ccc2[nH]c1=O
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383750
PNG
(US10280150, Cmpd No I-33 | US10550099, Compound I-...)
Show SMILES CCC(=O)Nc1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1
PDB

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PC sid
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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383765
PNG
(US10280150, Cmpd No I-48 | US10550099, Compound I-...)
Show SMILES CC(Nc1nccc(n1)N1CCOC1=O)c1cc2cc(Cl)ccc2[nH]c1=O
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383781
PNG
(US10280150, Cmpd No I-64 | US10550099, Compound I-...)
Show SMILES CC(C)n1cncc1-c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383798
PNG
(US10280150, Cmpd No I-81 | US10550099, Compound I-...)
Show SMILES C[C@H](Nc1nccc(n1)-c1cccn1C)c1cc2cc(Cl)ccc2[nH]c1=O
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383818
PNG
(US10280150, Cmpd No I-101 | US10550099, Compound I...)
Show SMILES C[C@H](Nc1nccc(n1)-c1ccccc1)c1cc2cc(Cl)ccc2[nH]c1=O
PDB

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PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383828
PNG
(US10280150, Cmpd No I-111 | US10550099, Compound I...)
Show SMILES C[C@H](Nc1nccc(n1)S(C)=O)c1cc2cc(Cl)ccc2[nH]c1=O
PDB

GoogleScholar
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PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383831
PNG
(US10280150, Cmpd No I-114 | US10550099, Compound I...)
Show SMILES C[C@H](Nc1nccc(n1)C(N)=O)c1cc2cc(Cl)ccc2[nH]c1=O
PDB

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PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132C


(Homo sapiens (Human))
BDBM383860
PNG
(US10280150, Cmpd No I-143 | US10550099, Compound I...)
Show SMILES COc1cc2[nH]c(=O)c(cc2cc1Cl)[C@H](C)Nc1ncc(C#N)c(OC)n1
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132C


(Homo sapiens (Human))
BDBM383866
PNG
(US10280150, Cmpd No I-149 | US10550099, Compound I...)
Show SMILES CC(Nc1nccc(NC(C)=O)n1)c1cc2cc(Cl)c(OCc3ccccn3)cc2[nH]c1=O
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132C


(Homo sapiens (Human))
BDBM383876
PNG
(US10280150, Cmpd No I-159 | US10550099, Compound I...)
Show SMILES COc1nc(N[C@@H](C)c2cc3cc(Cl)c(OCC4CC4)cc3[nH]c2=O)ncc1C#N
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383877
PNG
(US10280150, Cmpd No I-160 | US10550099, Compound I...)
Show SMILES C[C@H](Nc1nccc(NC(C)=O)n1)c1cc2cc(Cl)cc(F)c2[nH]c1=O
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383895
PNG
(US10280150, Cmpd No I-178 | US10550099, Compound I...)
Show SMILES C[C@H](Nc1ncc(C#N)c(=O)[nH]1)c1cc2cc(Cl)ccc2[nH]c1=O
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383718
PNG
(US10280150, Cmpd No I-1 | US10550099, Compound I-1)
Show SMILES C[C@H](Nc1nccc(n1)N(CC(C)(C)C)S(C)(=O)=O)c1cc2cc(Cl)ccc2[nH]c1=O
PDB

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PC cid
PC sid
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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132C


(Homo sapiens (Human))
BDBM383750
PNG
(US10280150, Cmpd No I-33 | US10550099, Compound I-...)
Show SMILES CCC(=O)Nc1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383759
PNG
(US10280150, Cmpd No I-42 | US10550099, Compound I-...)
Show SMILES CC(C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1
PDB

GoogleScholar
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PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132C


(Homo sapiens (Human))
BDBM383759
PNG
(US10280150, Cmpd No I-42 | US10550099, Compound I-...)
Show SMILES CC(C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1
PDB

GoogleScholar
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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383770
PNG
(US10280150, Cmpd No I-53)
Show SMILES C[C@H](Nc1nccc(n1)-n1ccc(C)c1C)c1cc2cc(Cl)ccc2[nH]c1=O
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383788
PNG
(US10280150, Cmpd No I-71 | US10550099, Compound I-...)
Show SMILES C[C@H](Nc1nccc(n1)-c1cncn1C)c1cc2cc(Cl)ccc2[nH]c1=O
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383797
PNG
(US10280150, Cmpd No I-80 | US10550099, Compound I-...)
Show SMILES C[C@H](Nc1nccc(n1)-c1cscc1C)c1cc2cc(Cl)ccc2[nH]c1=O
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383813
PNG
(US10280150, Cmpd No I-96 | US10550099, Compound I-...)
Show SMILES C[C@H](Nc1nccc(n1)-c1ccncc1C)c1cc2cc(Cl)ccc2[nH]c1=O
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383855
PNG
(US10280150, Cmpd No I-138 | US10550099, Compound I...)
Show SMILES C[C@H](Nc1nccc(n1)N1CCCC1=O)c1cc2cc(Cl)ccc2[nH]c1=O
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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132C


(Homo sapiens (Human))
BDBM383871
PNG
(US10280150, Cmpd No I-154 | US10550099, Compound I...)
Show SMILES COC(=O)Nc1ccnc(N[C@@H](C)c2cc3cc(Cl)c(OCc4ccccn4)cc3[nH]c2=O)n1
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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132C


(Homo sapiens (Human))
BDBM383877
PNG
(US10280150, Cmpd No I-160 | US10550099, Compound I...)
Show SMILES C[C@H](Nc1nccc(NC(C)=O)n1)c1cc2cc(Cl)cc(F)c2[nH]c1=O
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383892
PNG
(US10280150, Cmpd No I-175 | US10550099, Compound I...)
Show SMILES COc1nc(N[C@@H](C)c2cc3cc(Cl)c(OC(C)C)cc3[nH]c2=O)ncc1C#N
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383896
PNG
(US10280150, Cmpd No I-179 | US10550099, Compound I...)
Show SMILES C[C@H](Nc1nccc(NC(C)=O)n1)c1cc2cc(Cl)c(F)cc2[nH]c1=O
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383900
PNG
(US10280150, Cmpd No I-183 | US10550099, Compound I...)
Show SMILES C[C@H](Nc1nccc(n1)-n1nnnc1C1CC1)c1cc2cc(Cl)ccc2[nH]c1=O
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383719
PNG
(US10280150, Cmpd No I-2 | US10550099, Compound I-2)
Show SMILES C[C@H](Nc1nccc(n1)N(CC1CC1)S(C)(=O)=O)c1cc2cc(Cl)ccc2[nH]c1=O
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132C


(Homo sapiens (Human))
BDBM383721
PNG
(US10280150, Cmpd No I-4 | US10550099, Compound I-4)
Show SMILES CC(C)N(c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1)S(=O)(=O)c1cccnc1
PDB

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n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383722
PNG
(US10280150, Cmpd No I-5 | US10550099, Compound I-5)
Show SMILES CC(C)CS(=O)(=O)N(C(C)C)c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1
PDB

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n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132C


(Homo sapiens (Human))
BDBM383728
PNG
(US10280150, Cmpd No I-11 | US10550099, Compound I-...)
Show SMILES CC(C)N(c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1)S(=O)(=O)CC1CC1
PDB

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n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383742
PNG
(US10280150, Cmpd No I-25 | US10550099, Compound I-...)
Show SMILES C[C@H](Nc1nccc(NC(C)=O)n1)c1cc2cc(Cl)ccc2[nH]c1=O
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383756
PNG
(US10280150, Cmpd No I-39 | US10550099, Compound I-...)
Show SMILES C[C@H](Nc1ncc(C#N)c(C)n1)c1cc2cc(Cl)ccc2[nH]c1=O
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383757
PNG
(US10280150, Cmpd No I-40 | US10550099, Compound I-...)
Show SMILES C[C@H](Nc1ncc(C#N)c(n1)C1CC1)c1cc2cc(Cl)ccc2[nH]c1=O
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132C


(Homo sapiens (Human))
BDBM383763
PNG
(US10280150, Cmpd No I-46 | US10550099, Compound I-...)
Show SMILES CC(C)[C@H]1COC(=O)N1c1ccnc(NCc2cc3cc(Cl)ccc3[nH]c2=O)n1
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383768
PNG
(US10280150, Cmpd No I-51 | US10550099, Compound I-...)
Show SMILES C[C@H](Nc1nccc(n1)-n1cccc1C)c1cc2cc(Cl)ccc2[nH]c1=O
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383778
PNG
(US10280150, Cmpd No I-61 | US10550099, Compound I-...)
Show SMILES C[C@H](Nc1nccc(n1)-c1cncn1CC1CC1)c1cc2cc(Cl)ccc2[nH]c1=O
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132C


(Homo sapiens (Human))
BDBM383780
PNG
(US10280150, Cmpd No I-63 | US10550099, Compound I-...)
Show SMILES C[C@H](Nc1nccc(n1)-c1cnc2ccccn12)c1cc2cc(Cl)ccc2[nH]c1=O
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383796
PNG
(US10280150, Cmpd No I-79 | US10550099, Compound I-...)
Show SMILES C[C@H](Nc1nccc(n1)-c1ccnn1C1CCCCO1)c1cc2cc(Cl)ccc2[nH]c1=O
PDB

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n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383805
PNG
(US10280150, Cmpd No I-88 | US10550099, Compound I-...)
Show SMILES C[C@H](Nc1nccc(n1)-c1cnsc1)c1cc2cc(Cl)ccc2[nH]c1=O
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM383826
PNG
(US10280150, Cmpd No I-109 | US10550099, Compound I...)
Show SMILES CC(C)C[S@](=O)c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



FORMA TM2, INC.

US Patent


Assay Description
Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...


US Patent US10280150 (2019)


BindingDB Entry DOI: 10.7270/Q2QR50FF
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%