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Patent code US10280160

Compile Data Set for Download or QSAR
Found 31 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160522
PNG
(US10280160, Example 14. | US9682969, 14)
Show SMILES Cc1nc2ccc(cc2o1)N(C1CC1)C(=O)Cn1nc(-c2cccc(F)c2)c2ccc(O)cc2c1=O
Show InChI InChI=1S/C27H21FN4O4/c1-15-29-23-10-7-19(12-24(23)36-15)32(18-5-6-18)25(34)14-31-27(35)22-13-20(33)8-9-21(22)26(30-31)16-3-2-4-17(28)11-16/h2-4,7-13,18,33H,5-6,14H2,1H3
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US Patent
n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160516
PNG
(US10280160, Example 8. | US9682969, 8)
Show SMILES CCN(C(=O)Cn1nc(-c2cccc(F)c2)c2ccc(OC)cc2c1=O)c1ccc2nc(C)oc2c1
Show InChI InChI=1S/C27H23FN4O4/c1-4-31(19-8-11-23-24(13-19)36-16(2)29-23)25(33)15-32-27(34)22-14-20(35-3)9-10-21(22)26(30-32)17-6-5-7-18(28)12-17/h5-14H,4,15H2,1-3H3
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n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160526
PNG
(US10280160, Example 18. | US9682969, 18)
Show SMILES CCOc1ccc2c(nn(CC(=O)N(C3CC3)c3ccc4nc(C)oc4c3)c(=O)c2c1)-c1cccc(Cl)c1
Show InChI InChI=1S/C29H25ClN4O4/c1-3-37-22-10-11-23-24(15-22)29(36)33(32-28(23)18-5-4-6-19(30)13-18)16-27(35)34(20-7-8-20)21-9-12-25-26(14-21)38-17(2)31-25/h4-6,9-15,20H,3,7-8,16H2,1-2H3
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n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160525
PNG
(US10280160, Example 22. | US9682969, 17 | US968296...)
Show SMILES CCOc1ccc2c(nn(CC(=O)N(C)c3ccc4nc(C)oc4c3)c(=O)c2c1)-c1cccc(F)c1
Show InChI InChI=1S/C27H23FN4O4/c1-4-35-20-9-10-21-22(14-20)27(34)32(30-26(21)17-6-5-7-18(28)12-17)15-25(33)31(3)19-8-11-23-24(13-19)36-16(2)29-23/h5-14H,4,15H2,1-3H3
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n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160528
PNG
(US10280160, Example 25. | US9682969, 20 | US968296...)
Show SMILES CC(C)Oc1ccc2c(nn(CC(=O)N(C)c3ccc4nc(C)oc4c3)c(=O)c2c1)-c1cccc(Cl)c1
Show InChI InChI=1S/C28H25ClN4O4/c1-16(2)36-21-9-10-22-23(14-21)28(35)33(31-27(22)18-6-5-7-19(29)12-18)15-26(34)32(4)20-8-11-24-25(13-20)37-17(3)30-24/h5-14,16H,15H2,1-4H3
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n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160545
PNG
(US10280160, Example 30. | US9682969, 30)
Show SMILES CCOc1cc2c(cc1Cl)c(nn(CC(=O)N(C)c1ccc3nc(C)oc3c1)c2=O)-c1cccc(F)c1
Show InChI InChI=1S/C27H22ClFN4O4/c1-4-36-23-13-20-19(12-21(23)28)26(16-6-5-7-17(29)10-16)31-33(27(20)35)14-25(34)32(3)18-8-9-22-24(11-18)37-15(2)30-22/h5-13H,4,14H2,1-3H3
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n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160512
PNG
(US10280160, Example 6. | US9682969, 4 | US9682969,...)
Show SMILES COc1ccc2c(nn(CC(=O)N(C)c3ccc4nc(C)oc4c3)c(=O)c2c1)-c1cccc(Cl)c1
Show InChI InChI=1S/C26H21ClN4O4/c1-15-28-22-10-7-18(12-23(22)35-15)30(2)24(32)14-31-26(33)21-13-19(34-3)8-9-20(21)25(29-31)16-5-4-6-17(27)11-16/h4-13H,14H2,1-3H3
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n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160515
PNG
(US10280160, Example 9. | US9682969, 7 | US9682969,...)
Show SMILES CCN(C(=O)Cn1nc(-c2cccc(Cl)c2)c2ccc(OC)cc2c1=O)c1ccc2nc(C)oc2c1
Show InChI InChI=1S/C27H23ClN4O4/c1-4-31(19-8-11-23-24(13-19)36-16(2)29-23)25(33)15-32-27(34)22-14-20(35-3)9-10-21(22)26(30-32)17-6-5-7-18(28)12-17/h5-14H,4,15H2,1-3H3
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n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160519
PNG
(US10280160, Example 11. | US9682969, 11)
Show SMILES COc1cc2c(cc1Cl)c(nn(CC(=O)N(C)c1ccc3nc(C)oc3c1)c2=O)-c1cccc(Cl)c1
Show InChI InChI=1S/C26H20Cl2N4O4/c1-14-29-21-8-7-17(10-23(21)36-14)31(2)24(33)13-32-26(34)19-12-22(35-3)20(28)11-18(19)25(30-32)15-5-4-6-16(27)9-15/h4-12H,13H2,1-3H3
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n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160535
PNG
(US10280160, Example 27. | US9682969, 27)
Show SMILES CN(C(=O)Cn1nc(-c2cccc(F)c2)c2ccc(OC3CCOCC3)cc2c1=O)c1ccc2nc(C)oc2c1
Show InChI InChI=1S/C30H27FN4O5/c1-18-32-26-9-6-21(15-27(26)39-18)34(2)28(36)17-35-30(37)25-16-23(40-22-10-12-38-13-11-22)7-8-24(25)29(33-35)19-4-3-5-20(31)14-19/h3-9,14-16,22H,10-13,17H2,1-2H3
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n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160520
PNG
(US10280160, Example 12. | US9682969, 12)
Show SMILES COc1ccc2c(nn(CC(=O)N(C3CC3)c3ccc4nc(C)oc4c3)c(=O)c2c1)-c1cccc(F)c1
Show InChI InChI=1S/C28H23FN4O4/c1-16-30-24-11-8-20(13-25(24)37-16)33(19-6-7-19)26(34)15-32-28(35)23-14-21(36-2)9-10-22(23)27(31-32)17-4-3-5-18(29)12-17/h3-5,8-14,19H,6-7,15H2,1-2H3
PDB

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n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160524
PNG
(US10280160, Example 16. | US9682969, 16)
Show SMILES CN(C(=O)Cn1nc(-c2cccc(Cl)c2)c2ccc(O)cc2c1=O)c1ccc2nc(C)oc2c1
Show InChI InChI=1S/C25H19ClN4O4/c1-14-27-21-9-6-17(11-22(21)34-14)29(2)23(32)13-30-25(33)20-12-18(31)7-8-19(20)24(28-30)15-4-3-5-16(26)10-15/h3-12,31H,13H2,1-2H3
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n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160525
PNG
(US10280160, Example 22. | US9682969, 17 | US968296...)
Show SMILES CCOc1ccc2c(nn(CC(=O)N(C)c3ccc4nc(C)oc4c3)c(=O)c2c1)-c1cccc(F)c1
Show InChI InChI=1S/C27H23FN4O4/c1-4-35-20-9-10-21-22(14-20)27(34)32(30-26(21)17-6-5-7-18(28)12-17)15-25(33)31(3)19-8-11-23-24(13-19)36-16(2)29-23/h5-14H,4,15H2,1-3H3
PDB

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n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160528
PNG
(US10280160, Example 25. | US9682969, 20 | US968296...)
Show SMILES CC(C)Oc1ccc2c(nn(CC(=O)N(C)c3ccc4nc(C)oc4c3)c(=O)c2c1)-c1cccc(Cl)c1
Show InChI InChI=1S/C28H25ClN4O4/c1-16(2)36-21-9-10-22-23(14-21)28(35)33(31-27(22)18-6-5-7-19(29)12-18)15-26(34)32(4)20-8-11-24-25(13-20)37-17(3)30-24/h5-14,16H,15H2,1-4H3
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n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160509
PNG
(US10280160, Example 1. | US9682969, 1)
Show SMILES CN(C(=O)Cn1nc(-c2cccc(Cl)c2)c2ccccc2c1=O)c1ccc2nc(C)oc2c1
Show InChI InChI=1S/C25H19ClN4O3/c1-15-27-21-11-10-18(13-22(21)33-15)29(2)23(31)14-30-25(32)20-9-4-3-8-19(20)24(28-30)16-6-5-7-17(26)12-16/h3-13H,14H2,1-2H3
PDB

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n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160510
PNG
(US10280160, Example 2. | US9682969, 2)
Show SMILES CN(C(=O)Cn1nc(-c2cccc(F)c2)c2ccccc2c1=O)c1ccc2nc(C)oc2c1
Show InChI InChI=1S/C25H19FN4O3/c1-15-27-21-11-10-18(13-22(21)33-15)29(2)23(31)14-30-25(32)20-9-4-3-8-19(20)24(28-30)16-6-5-7-17(26)12-16/h3-13H,14H2,1-2H3
PDB

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n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160513
PNG
(US10280160, Example 5. | US9682969, 5)
Show SMILES COc1ccc2c(nn(CC(=O)N(C3CC3)c3ccc4nc(C)oc4c3)c(=O)c2c1)-c1cccc(Cl)c1
Show InChI InChI=1S/C28H23ClN4O4/c1-16-30-24-11-8-20(13-25(24)37-16)33(19-6-7-19)26(34)15-32-28(35)23-14-21(36-2)9-10-22(23)27(31-32)17-4-3-5-18(29)12-17/h3-5,8-14,19H,6-7,15H2,1-2H3
PDB

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n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160515
PNG
(US10280160, Example 9. | US9682969, 7 | US9682969,...)
Show SMILES CCN(C(=O)Cn1nc(-c2cccc(Cl)c2)c2ccc(OC)cc2c1=O)c1ccc2nc(C)oc2c1
Show InChI InChI=1S/C27H23ClN4O4/c1-4-31(19-8-11-23-24(13-19)36-16(2)29-23)25(33)15-32-27(34)22-14-20(35-3)9-10-21(22)26(30-32)17-6-5-7-18(28)12-17/h5-14H,4,15H2,1-3H3
PDB

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n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160529
PNG
(US10280160, Example 21. | US9682969, 21)
Show SMILES CCOc1ccc2c(nn(CC(=O)N(C3CC3)c3ccc4nc(C)oc4c3)c(=O)c2c1)-c1cccc(F)c1
Show InChI InChI=1S/C29H25FN4O4/c1-3-37-22-10-11-23-24(15-22)29(36)33(32-28(23)18-5-4-6-19(30)13-18)16-27(35)34(20-7-8-20)21-9-12-25-26(14-21)38-17(2)31-25/h4-6,9-15,20H,3,7-8,16H2,1-2H3
PDB

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US Patent
n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160511
PNG
(US10280160, Example 3. | US9682969, 3)
Show SMILES COc1ccc2c(nn(CC(=O)N(C)c3ccc4nc(C)oc4c3)c(=O)c2c1)-c1cccc(F)c1
Show InChI InChI=1S/C26H21FN4O4/c1-15-28-22-10-7-18(12-23(22)35-15)30(2)24(32)14-31-26(33)21-13-19(34-3)8-9-20(21)25(29-31)16-5-4-6-17(27)11-16/h4-13H,14H2,1-3H3
PDB

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n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160531
PNG
(US10280160, Example 24. | US9682969, 23 | US968296...)
Show SMILES CN(C(=O)Cn1nc(-c2cccc(Cl)c2)c2ccc(OCC3CC3)cc2c1=O)c1ccc2nc(C)oc2c1
Show InChI InChI=1S/C29H25ClN4O4/c1-17-31-25-11-8-21(13-26(25)38-17)33(2)27(35)15-34-29(36)24-14-22(37-16-18-6-7-18)9-10-23(24)28(32-34)19-4-3-5-20(30)12-19/h3-5,8-14,18H,6-7,15-16H2,1-2H3
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n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160512
PNG
(US10280160, Example 6. | US9682969, 4 | US9682969,...)
Show SMILES COc1ccc2c(nn(CC(=O)N(C)c3ccc4nc(C)oc4c3)c(=O)c2c1)-c1cccc(Cl)c1
Show InChI InChI=1S/C26H21ClN4O4/c1-15-28-22-10-7-18(12-23(22)35-15)30(2)24(32)14-31-26(33)21-13-19(34-3)8-9-20(21)25(29-31)16-5-4-6-17(27)11-16/h4-13H,14H2,1-3H3
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n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160521
PNG
(US10280160, Example 13. | US9682969, 13)
Show SMILES CN(C(=O)Cn1nc(-c2cccc(F)c2)c2ccc(O)cc2c1=O)c1ccc2nc(C)oc2c1
Show InChI InChI=1S/C25H19FN4O4/c1-14-27-21-9-6-17(11-22(21)34-14)29(2)23(32)13-30-25(33)20-12-18(31)7-8-19(20)24(28-30)15-4-3-5-16(26)10-15/h3-12,31H,13H2,1-2H3
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n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160536
PNG
(US10280160, Example 28. | US9682969, 28)
Show SMILES CN(C(=O)Cn1nc(-c2cccc(F)c2)c2ccc(OC3CCCCC3)cc2c1=O)c1ccc2nc(C)oc2c1
Show InChI InChI=1S/C31H29FN4O4/c1-19-33-27-14-11-22(16-28(27)39-19)35(2)29(37)18-36-31(38)26-17-24(40-23-9-4-3-5-10-23)12-13-25(26)30(34-36)20-7-6-8-21(32)15-20/h6-8,11-17,23H,3-5,9-10,18H2,1-2H3
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n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160537
PNG
(US10280160, Example 29. | US9682969, 29)
Show SMILES CN(C(=O)Cn1nc(-c2cccc(Cl)c2)c2ccc(OC3CCOCC3)cc2c1=O)c1ccc2nc(C)oc2c1
Show InChI InChI=1S/C30H27ClN4O5/c1-18-32-26-9-6-21(15-27(26)39-18)34(2)28(36)17-35-30(37)25-16-23(40-22-10-12-38-13-11-22)7-8-24(25)29(33-35)19-4-3-5-20(31)14-19/h3-9,14-16,22H,10-13,17H2,1-2H3
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n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160546
PNG
(US10280160, Example 31. | US9682969, 31)
Show SMILES CCOc1cc2c(cc1Cl)c(nn(CC(=O)N(C)c1ccc3nc(C)oc3c1)c2=O)-c1cccc(Cl)c1
Show InChI InChI=1S/C27H22Cl2N4O4/c1-4-36-23-13-20-19(12-21(23)29)26(16-6-5-7-17(28)10-16)31-33(27(20)35)14-25(34)32(3)18-8-9-22-24(11-18)37-15(2)30-22/h5-13H,4,14H2,1-3H3
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n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160518
PNG
(US10280160, Example 10. | US9682969, 10)
Show SMILES COc1cc2c(cc1Cl)c(nn(CC(=O)N(C)c1ccc3nc(C)oc3c1)c2=O)-c1cccc(F)c1
Show InChI InChI=1S/C26H20ClFN4O4/c1-14-29-21-8-7-17(10-23(21)36-14)31(2)24(33)13-32-26(34)19-12-22(35-3)20(27)11-18(19)25(30-32)15-5-4-6-16(28)9-15/h4-12H,13H2,1-3H3
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n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160527
PNG
(US10280160, Example 19. | US9682969, 19)
Show SMILES CCOc1ccc2c(nn(CC(=O)N(C)c3ccc4nc(C)oc4c3)c(=O)c2c1)-c1cccc(Cl)c1
Show InChI InChI=1S/C27H23ClN4O4/c1-4-35-20-9-10-21-22(14-20)27(34)32(30-26(21)17-6-5-7-18(28)12-17)15-25(33)31(3)19-8-11-23-24(13-19)36-16(2)29-23/h5-14H,4,15H2,1-3H3
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n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160531
PNG
(US10280160, Example 24. | US9682969, 23 | US968296...)
Show SMILES CN(C(=O)Cn1nc(-c2cccc(Cl)c2)c2ccc(OCC3CC3)cc2c1=O)c1ccc2nc(C)oc2c1
Show InChI InChI=1S/C29H25ClN4O4/c1-17-31-25-11-8-21(13-26(25)38-17)33(2)27(35)15-34-29(36)24-14-22(37-16-18-6-7-18)9-10-23(24)28(32-34)19-4-3-5-20(30)12-19/h3-5,8-14,18H,6-7,15-16H2,1-2H3
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n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160534
PNG
(US10280160, Example 26. | US9682969, 26)
Show SMILES CN(C(=O)Cn1nc(-c2cccc(Cl)c2)c2ccc(OC3CCCCC3)cc2c1=O)c1ccc2nc(C)oc2c1
Show InChI InChI=1S/C31H29ClN4O4/c1-19-33-27-14-11-22(16-28(27)39-19)35(2)29(37)18-36-31(38)26-17-24(40-23-9-4-3-5-10-23)12-13-25(26)30(34-36)20-7-6-8-21(32)15-20/h6-8,11-17,23H,3-5,9-10,18H2,1-2H3
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n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))
BDBM160523
PNG
(US10280160, Example 15. | US9682969, 15)
Show SMILES Cc1nc2ccc(cc2o1)N(C1CC1)C(=O)Cn1nc(-c2cccc(Cl)c2)c2ccc(O)cc2c1=O
Show InChI InChI=1S/C27H21ClN4O4/c1-15-29-23-10-7-19(12-24(23)36-15)32(18-5-6-18)25(34)14-31-27(35)22-13-20(33)8-9-21(22)26(30-31)16-3-2-4-17(28)11-16/h2-4,7-13,18,33H,5-6,14H2,1H3
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n/an/an/an/a<1.00E+4n/an/an/an/a



FLATLEY DISCOVERY LAB, LLC

US Patent


Assay Description
Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...


US Patent US10280160 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%