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Patent code US10280164

Compile Data Set for Download or QSAR
Found 16 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM383906
PNG
(US10280164, Example 5)
Show SMILES COc1cccc(F)c1-n1cc2c(n[nH]c2cc1=O)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C24H24FN5O2/c1-28-10-12-29(13-11-28)17-8-6-16(7-9-17)23-18-15-30(22(31)14-20(18)26-27-23)24-19(25)4-3-5-21(24)32-2/h3-9,14-15,26H,10-13H2,1-2H3
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<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10280164 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM383904
PNG
(US10280164, Example 3)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cc(=O)n(cc12)-c1ccccc1C
Show InChI InChI=1S/C24H25N5O/c1-17-5-3-4-6-22(17)29-16-20-21(15-23(29)30)25-26-24(20)18-7-9-19(10-8-18)28-13-11-27(2)12-14-28/h3-10,15-16,25H,11-14H2,1-2H3
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<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10280164 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM383909
PNG
(US10280164, Example 8)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cc(=O)n(cc12)-c1ncccc1F
Show InChI InChI=1S/C22H21FN6O/c1-27-9-11-28(12-10-27)16-6-4-15(5-7-16)21-17-14-29(20(30)13-19(17)25-26-21)22-18(23)3-2-8-24-22/h2-8,13-14,25H,9-12H2,1H3
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<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10280164 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM383905
PNG
(US10280164, Example 4)
Show SMILES COc1ccccc1-n1cc2c(n[nH]c2cc1=O)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C24H25N5O2/c1-27-11-13-28(14-12-27)18-9-7-17(8-10-18)24-19-16-29(23(30)15-20(19)25-26-24)21-5-3-4-6-22(21)31-2/h3-10,15-16,25H,11-14H2,1-2H3
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<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10280164 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM383903
PNG
(US10280164, Example 2)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cc(=O)n(cc12)-c1ccccc1F
Show InChI InChI=1S/C23H22FN5O/c1-27-10-12-28(13-11-27)17-8-6-16(7-9-17)23-18-15-29(21-5-3-2-4-19(21)24)22(30)14-20(18)25-26-23/h2-9,14-15,25H,10-13H2,1H3
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<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10280164 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM383908
PNG
(US10280164, Example 7)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cc(=O)n(cc12)-c1cccc2OCCOc12
Show InChI InChI=1S/C25H25N5O3/c1-28-9-11-29(12-10-28)18-7-5-17(6-8-18)24-19-16-30(23(31)15-20(19)26-27-24)21-3-2-4-22-25(21)33-14-13-32-22/h2-8,15-16,26H,9-14H2,1H3
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<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10280164 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM383914
PNG
(US10280164, Example 13)
Show SMILES CC(c1ccccc1C(F)(F)F)n1cc2c(n[nH]c2cc1=O)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1/C26H26F3N5O/c1-17(20-5-3-4-6-22(20)26(27,28)29)34-16-21-23(15-24(34)35)30-31-25(21)18-7-9-19(10-8-18)33-13-11-32(2)12-14-33/h3-10,15-17,30H,11-14H2,1-2H3
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<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10280164 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM383915
PNG
(US10280164, Example 14)
Show SMILES CC(c1ccccc1)n1cc2c(n[nH]c2cc1=O)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1/C25H27N5O/c1-18(19-6-4-3-5-7-19)30-17-22-23(16-24(30)31)26-27-25(22)20-8-10-21(11-9-20)29-14-12-28(2)13-15-29/h3-11,16-18,26H,12-15H2,1-2H3
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<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10280164 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM383907
PNG
(US10280164, Example 6)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cc(=O)n(cc12)-c1cccc2CNCCc12
Show InChI InChI=1S/C26H28N6O/c1-30-11-13-31(14-12-30)20-7-5-18(6-8-20)26-22-17-32(25(33)15-23(22)28-29-26)24-4-2-3-19-16-27-10-9-21(19)24/h2-8,15,17,27-28H,9-14,16H2,1H3
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<100n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10280164 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM383913
PNG
(US10280164, Example 12)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cc(=O)n(CC3CCCCC3)cc12
Show InChI InChI=1S/C24H31N5O/c1-27-11-13-28(14-12-27)20-9-7-19(8-10-20)24-21-17-29(16-18-5-3-2-4-6-18)23(30)15-22(21)25-26-24/h7-10,15,17-18,25H,2-6,11-14,16H2,1H3
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300n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10280164 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM383902
PNG
(US10280164, Example 1)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cc(=O)n(cc12)-c1ccccc1
Show InChI InChI=1S/C23H23N5O/c1-26-11-13-27(14-12-26)18-9-7-17(8-10-18)23-20-16-28(19-5-3-2-4-6-19)22(29)15-21(20)24-25-23/h2-10,15-16,24H,11-14H2,1H3
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300n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10280164 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM383917
PNG
(US10280164, Example 16)
Show SMILES CC1OCCCC1n1cc2c(n[nH]c2cc1=O)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1/C23H29N5O2/c1-16-21(4-3-13-30-16)28-15-19-20(14-22(28)29)24-25-23(19)17-5-7-18(8-6-17)27-11-9-26(2)10-12-27/h5-8,14-16,21,24H,3-4,9-13H2,1-2H3
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300n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10280164 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM383910
PNG
(US10280164, Example 9)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cc(=O)n(cc12)C1CCCCC1
Show InChI InChI=1S/C23H29N5O/c1-26-11-13-27(14-12-26)18-9-7-17(8-10-18)23-20-16-28(19-5-3-2-4-6-19)22(29)15-21(20)24-25-23/h7-10,15-16,19,24H,2-6,11-14H2,1H3
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300n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10280164 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM383912
PNG
(US10280164, Example 11)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cc(=O)n(Cc3ccccc3)cc12
Show InChI InChI=1S/C24H25N5O/c1-27-11-13-28(14-12-27)20-9-7-19(8-10-20)24-21-17-29(16-18-5-3-2-4-6-18)23(30)15-22(21)25-26-24/h2-10,15,17,25H,11-14,16H2,1H3
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300n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10280164 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM383911
PNG
(US10280164, Example 10)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cc(=O)n(cc12)C1CCOC1
Show InChI InChI=1/C21H25N5O2/c1-24-7-9-25(10-8-24)16-4-2-15(3-5-16)21-18-13-26(17-6-11-28-14-17)20(27)12-19(18)22-23-21/h2-5,12-13,17,22H,6-11,14H2,1H3
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1.75E+3n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10280164 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM383916
PNG
(US10280164, Example 15)
Show SMILES CN1CCC(C1=O)n1cc2c(n[nH]c2cc1=O)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1/C22H26N6O2/c1-25-9-11-27(12-10-25)16-5-3-15(4-6-16)21-17-14-28(19-7-8-26(2)22(19)30)20(29)13-18(17)23-24-21/h3-6,13-14,19,23H,7-12H2,1-2H3
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1.75E+3n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US10280164 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%