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Patent code US10280167

Compile Data Set for Download or QSAR
Found 39 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384107
PNG
(US10280167, Example 36)
Show SMILES Nc1nc(nc2n(Cc3ccccc3)c(=O)[nH]c12)-n1cccn1
Show InChI InChI=1S/C15H13N7O/c16-12-11-13(20-14(19-12)22-8-4-7-17-22)21(15(23)18-11)9-10-5-2-1-3-6-10/h1-8H,9H2,(H,18,23)(H2,16,19,20)
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 47n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384087
PNG
(US10280167, Example 10)
Show SMILES Nc1nc(nc2n(CC3CCOCC3)c(=O)[nH]c12)-c1nc(c[nH]1)C1CC1
Show InChI InChI=1S/C17H19N7O2/c18-13-12-16(24(17(25)21-12)8-9-3-5-26-6-4-9)23-15(22-13)14-19-7-11(20-14)10-1-2-10/h7,9-10H,1-6,8H2,(H2,18,22)/b15-14+
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 730n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384078
PNG
(US10280167, Example 1)
Show SMILES Nc1nc(nc2n(Cc3ccccc3)c(=O)[nH]c12)-c1nc(c[nH]1)C1CC1
Show InChI InChI=1S/C18H15N7O/c19-14-13-17(25(18(26)22-13)9-10-4-2-1-3-5-10)24-16(23-14)15-20-8-12(21-15)11-6-7-11/h1-5,8,11H,6-7,9H2,(H2,19,23)/b16-15+
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 81n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384082
PNG
(US10280167, Example 5)
Show SMILES Cc1[nH]c(nc1C1CC1)-c1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1
Show InChI InChI=1S/C19H17N7O/c1-10-13(12-7-8-12)22-16(21-10)17-24-15(20)14-18(25-17)26(19(27)23-14)9-11-5-3-2-4-6-11/h2-6,12H,7-9H2,1H3,(H2,20,24)/b17-16+
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 200n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384089
PNG
(US10280167, Example 12)
Show SMILES Cn1ccnc1-c1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1
Show InChI InChI=1S/C16H15N7O/c1-22-8-7-18-15(22)13-20-12(17)11-14(21-13)23(16(24)19-11)9-10-5-3-2-4-6-10/h2-8H,9H2,1H3,(H,19,24)(H2,17,20,21)
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 590n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384098
PNG
(US10280167, Example 27)
Show SMILES Nc1nc(nc2n(Cc3ccccc3)c(=O)[nH]c12)-c1nccn1CCO
Show InChI InChI=1S/C17H17N7O2/c18-13-12-15(22-14(21-13)16-19-6-7-23(16)8-9-25)24(17(26)20-12)10-11-4-2-1-3-5-11/h1-7,25H,8-10H2,(H,20,26)(H2,18,21,22)
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 800n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384101
PNG
(US10280167, Example 30)
Show SMILES CCc1c[nH]c(n1)-c1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1
Show InChI InChI=1S/C17H15N7O/c1-2-11-8-19-14(20-11)15-22-13(18)12-16(23-15)24(17(25)21-12)9-10-6-4-3-5-7-10/h3-8H,2,9H2,1H3,(H2,18,22)/b15-14+
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 170n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384105
PNG
(US10280167, Example 34)
Show SMILES COCCc1nnc(o1)-c1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1
Show InChI InChI=1S/C17H17N7O3/c1-26-8-7-11-22-23-16(27-11)14-20-13(18)12-15(21-14)24(17(25)19-12)9-10-5-3-2-4-6-10/h2-6H,7-9H2,1H3,(H,19,25)(H2,18,20,21)
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 690n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384111
PNG
(US10280167, Example 57)
Show SMILES COC(=O)COc1ccc(Cn2c3nc(nc(N)c3[nH]c2=O)-c2ncc[nH]2)cn1
Show InChI InChI=1S/C17H14N8O4/c1-28-11(26)8-29-10-3-2-9(6-21-10)7-25-16-12(22-17(25)27)13(18)23-15(24-16)14-19-4-5-20-14/h2-6H,7-8H2,1H3,(H2,18,23)
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 1.21E+3n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384113
PNG
(US10280167, Example 60)
Show SMILES Nc1nc(nc2n(Cc3ccc4CCNCc4c3)c(=O)[nH]c12)-c1nc(c[nH]1)C1CC1
Show InChI InChI=1S/C21H20N8O/c22-17-16-20(28-19(27-17)18-24-9-15(25-18)13-3-4-13)29(21(30)26-16)10-11-1-2-12-5-6-23-8-14(12)7-11/h1-2,7,9,13,23H,3-6,8,10H2,(H2,22,27)/b19-18+
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 34n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384114
PNG
(US10280167, Example 61)
Show SMILES CN1CCN(CCCCCn2c3nc(nc(N)c3[nH]c2=O)-c2ncc[nH]2)CC1
Show InChI InChI=1S/C18H25N9O/c1-25-9-11-26(12-10-25)7-3-2-4-8-27-17-13(22-18(27)28)14(19)23-16(24-17)15-20-5-6-21-15/h5-6H,2-4,7-12H2,1H3,(H2,19,23)
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 1.34E+3n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384096
PNG
(US10280167, Example 25)
Show SMILES Nc1nc(nc2n(Cc3cccc(CN4CCCC4)c3)c(=O)[nH]c12)-c1ncc[nH]1
Show InChI InChI=1S/C20H20N8O/c21-16-15-19(26-18(25-16)17-22-6-7-23-17)28(20(29)24-15)12-14-5-3-4-13(10-14)11-27-8-1-2-9-27/h3-7,10H,1-2,8-9,11-12H2,(H2,21,25)
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 6n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384099
PNG
(US10280167, Example 28)
Show SMILES CC(C)(C)c1c[nH]c(n1)-c1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1
Show InChI InChI=1S/C19H19N7O/c1-19(2,3)12-9-21-15(22-12)16-24-14(20)13-17(25-16)26(18(27)23-13)10-11-7-5-4-6-8-11/h4-9H,10H2,1-3H3,(H2,20,24)/b16-15+
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a>2.38E+4n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384091
PNG
(US10280167, Example 18)
Show SMILES Nc1nc(nc2n(Cc3ccccc3)c(=O)[nH]c12)-c1ccc[nH]1
Show InChI InChI=1S/C16H12N6O/c17-13-12-15(21-14(20-13)11-7-4-8-18-11)22(16(23)19-12)9-10-5-2-1-3-6-10/h1-8H,9H2,(H2,17,20)/b14-11+
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 2.58E+3n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384100
PNG
(US10280167, Example 29)
Show SMILES CC(C)c1c[nH]c(n1)-c1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1
Show InChI InChI=1S/C18H17N7O/c1-10(2)12-8-20-15(21-12)16-23-14(19)13-17(24-16)25(18(26)22-13)9-11-6-4-3-5-7-11/h3-8,10H,9H2,1-2H3,(H2,19,23)/b16-15+
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 1.66E+3n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384102
PNG
(US10280167, Example 31)
Show SMILES Nc1nc(nc2n(Cc3ccccc3)c(=O)[nH]c12)-c1nc(c[nH]1)C(F)(F)F
Show InChI InChI=1S/C16H10F3N7O/c17-16(18,19)9-6-21-12(22-9)13-24-11(20)10-14(25-13)26(15(27)23-10)7-8-4-2-1-3-5-8/h1-6H,7H2,(H2,20,24)/b13-12+
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 1.30E+3n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384106
PNG
(US10280167, Example 35)
Show SMILES Cc1cnn(c1)-c1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1
Show InChI InChI=1S/C16H15N7O/c1-10-7-18-23(8-10)15-20-13(17)12-14(21-15)22(16(24)19-12)9-11-5-3-2-4-6-11/h2-8H,9H2,1H3,(H,19,24)(H2,17,20,21)
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 170n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384110
PNG
(US10280167, Example 55)
Show SMILES Nc1nc(nc2n(Cc3cccc(c3)C(=O)N3CCCC3)c(=O)[nH]c12)-c1nnc[nH]1
Show InChI InChI=1S/C19H17N9O2/c20-14-13-17(25-16(24-14)15-21-10-22-26-15)28(19(30)23-13)9-11-4-3-5-12(8-11)18(29)27-6-1-2-7-27/h3-5,8,10H,1-2,6-7,9H2,(H2,20,24)/b16-15+
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 1.27E+3n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384079
PNG
(US10280167, Example 2)
Show SMILES Nc1nc(nc2n(Cc3ccccc3)c(=O)[nH]c12)-c1nc(c[nH]1)-c1ccccc1
Show InChI InChI=1S/C21H15N7O/c22-17-16-20(28(21(29)25-16)12-13-7-3-1-4-8-13)27-19(26-17)18-23-11-15(24-18)14-9-5-2-6-10-14/h1-11H,12H2,(H2,22,26)/b19-18+
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 531n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384085
PNG
(US10280167, Example 8)
Show SMILES Cc1c[nH]c(n1)-c1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1
Show InChI InChI=1S/C16H13N7O/c1-9-7-18-13(19-9)14-21-12(17)11-15(22-14)23(16(24)20-11)8-10-5-3-2-4-6-10/h2-7H,8H2,1H3,(H2,17,21)/b14-13+
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 170n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384094
PNG
(US10280167, Example 23)
Show SMILES Nc1nc(nc2n(Cc3ccccc3)c(=O)[nH]c12)-c1ccn[nH]1
Show InChI InChI=1S/C15H11N7O/c16-12-11-14(20-13(19-12)10-6-7-17-21-10)22(15(23)18-11)8-9-4-2-1-3-5-9/h1-7H,8H2,(H2,16,19)/b13-10+
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 130n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384104
PNG
(US10280167, Example 33)
Show SMILES Cc1noc(n1)-c1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1
Show InChI InChI=1S/C15H13N7O2/c1-8-17-14(24-21-8)12-19-11(16)10-13(20-12)22(15(23)18-10)7-9-5-3-2-4-6-9/h2-6H,7H2,1H3,(H,18,23)(H2,16,19,20)
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 810n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384084
PNG
(US10280167, Example 7)
Show SMILES Cc1nc([nH]c1C)-c1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1
Show InChI InChI=1S/C17H15N7O/c1-9-10(2)20-14(19-9)15-22-13(18)12-16(23-15)24(17(25)21-12)8-11-6-4-3-5-7-11/h3-7H,8H2,1-2H3,(H2,18,22)
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 640n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384090
PNG
(US10280167, Example 15)
Show SMILES Nc1nc(nc2n(Cc3ccccc3)c(=O)[nH]c12)-c1cncnc1
Show InChI InChI=1S/C16H13N7O/c17-13-12-15(22-14(21-13)11-6-18-9-19-7-11)23(16(24)20-12)8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H,20,24)(H2,17,21,22)
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 1.69E+4n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384092
PNG
(US10280167, Example 19)
Show SMILES Nc1nc(nc2n(Cc3ccccc3)c(=O)[nH]c12)-c1cn[nH]c1
Show InChI InChI=1S/C15H11N7O/c16-12-11-14(21-13(20-12)10-6-17-18-7-10)22(15(23)19-11)8-9-4-2-1-3-5-9/h1-7H,8H2,(H2,16,20)
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 1.24E+4n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384093
PNG
(US10280167, Example 20)
Show SMILES Nc1nc(nc2n(Cc3ccccc3)c(=O)[nH]c12)-c1ccco1
Show InChI InChI=1S/C16H13N5O2/c17-13-12-15(20-14(19-13)11-7-4-8-23-11)21(16(22)18-12)9-10-5-2-1-3-6-10/h1-8H,9H2,(H,18,22)(H2,17,19,20)
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 680n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384097
PNG
(US10280167, Example 26)
Show SMILES Cc1ccc(Cn2c3nc(nc(N)c3[nH]c2=O)-c2nc(c[nH]2)C2CC2)cn1
Show InChI InChI=1S/C18H16N8O/c1-9-2-3-10(6-20-9)8-26-17-13(23-18(26)27)14(19)24-16(25-17)15-21-7-12(22-15)11-4-5-11/h2-3,6-7,11H,4-5,8H2,1H3,(H2,19,24)/b16-15+
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 5n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384116
PNG
(US10280167, Example 63)
Show SMILES Nc1nc(nc2n(CC3CCOCC3)c(=O)[nH]c12)-c1ncc[nH]1
Show InChI InChI=1S/C14H15N7O2/c15-10-9-13(20-12(19-10)11-16-3-4-17-11)21(14(22)18-9)7-8-1-5-23-6-2-8/h3-4,8H,1-2,5-7H2,(H2,15,19)
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 6.72E+3n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384080
PNG
(US10280167, Example 3)
Show SMILES Nc1nc(nc2n(Cc3ccccc3)c(=O)[nH]c12)-c1nc(c[nH]1)C1CCCC1
Show InChI InChI=1S/C20H19N7O/c21-16-15-19(27(20(28)24-15)11-12-6-2-1-3-7-12)26-18(25-16)17-22-10-14(23-17)13-8-4-5-9-13/h1-3,6-7,10,13H,4-5,8-9,11H2,(H2,21,25)/b18-17+
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 1.40E+4n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384081
PNG
(US10280167, Example 4)
Show SMILES Nc1nc(nc2n(Cc3ccccc3)c(=O)[nH]c12)-c1ncc[nH]1
Show InChI InChI=1S/C15H11N7O/c16-11-10-14(21-13(20-11)12-17-6-7-18-12)22(15(23)19-10)8-9-4-2-1-3-5-9/h1-7H,8H2,(H2,16,20)
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 160n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384086
PNG
(US10280167, Example 9)
Show SMILES Cc1ccc(Cn2c3nc(nc(N)c3[nH]c2=O)-c2ncc[nH]2)cn1
Show InChI InChI=1S/C15H12N8O/c1-8-2-3-9(6-19-8)7-23-14-10(20-15(23)24)11(16)21-13(22-14)12-17-4-5-18-12/h2-6H,7H2,1H3,(H2,16,21)
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 50n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384088
PNG
(US10280167, Example 11)
Show SMILES COCCn1ccnc1-c1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1
Show InChI InChI=1S/C18H19N7O2/c1-27-10-9-24-8-7-20-17(24)15-22-14(19)13-16(23-15)25(18(26)21-13)11-12-5-3-2-4-6-12/h2-8H,9-11H2,1H3,(H,21,26)(H2,19,22,23)
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 330n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384103
PNG
(US10280167, Example 32)
Show SMILES Nc1nc(nc2n(Cc3ccccc3)c(=O)[nH]c12)-c1cnco1
Show InChI InChI=1S/C15H12N6O2/c16-12-11-14(20-13(19-12)10-6-17-8-23-10)21(15(22)18-11)7-9-4-2-1-3-5-9/h1-6,8H,7H2,(H,18,22)(H2,16,19,20)
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 1.51E+3n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384095
PNG
(US10280167, Example 24)
Show SMILES Nc1nc(nc2n(Cc3ccc4CCNCc4c3)c(=O)[nH]c12)-c1ncc[nH]1
Show InChI InChI=1S/C18H16N8O/c19-14-13-17(25-16(24-14)15-21-5-6-22-15)26(18(27)23-13)9-10-1-2-11-3-4-20-8-12(11)7-10/h1-2,5-7,20H,3-4,8-9H2,(H2,19,24)
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 46n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384108
PNG
(US10280167, Example 53)
Show SMILES Cc1cn[nH]c1-c1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1
Show InChI InChI=1S/C16H13N7O/c1-9-7-18-22-11(9)14-20-13(17)12-15(21-14)23(16(24)19-12)8-10-5-3-2-4-6-10/h2-7H,8H2,1H3,(H2,17,20)/b14-11+
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 760n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384109
PNG
(US10280167, Example 54)
Show SMILES CN(C)CCOc1ccc(Cn2c3nc(nc(N)c3[nH]c2=O)-c2nc(c[nH]2)C2CC2)cn1
Show InChI InChI=1S/C21H23N9O2/c1-29(2)7-8-32-15-6-3-12(9-23-15)11-30-20-16(26-21(30)31)17(22)27-19(28-20)18-24-10-14(25-18)13-4-5-13/h3,6,9-10,13H,4-5,7-8,11H2,1-2H3,(H2,22,27)/b19-18+
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 50n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384112
PNG
(US10280167, Example 58)
Show SMILES Nc1nc(nc2n(Cc3ccc(OCC(O)=O)nc3)c(=O)[nH]c12)-c1ncc[nH]1
Show InChI InChI=1S/C16H12N8O4/c17-12-11-15(23-14(22-12)13-18-3-4-19-13)24(16(27)21-11)6-8-1-2-9(20-5-8)28-7-10(25)26/h1-5H,6-7H2,(H2,17,22)(H,25,26)
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 2.75E+3n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384083
PNG
(US10280167, Example 6)
Show SMILES CCc1[nH]c(nc1C1CC1)-c1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1
Show InChI InChI=1S/C20H19N7O/c1-2-13-14(12-8-9-12)23-17(22-13)18-25-16(21)15-19(26-18)27(20(28)24-15)10-11-6-4-3-5-7-11/h3-7,12H,2,8-10H2,1H3,(H2,21,25)/b18-17+
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 53n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase


(Hepatitis C virus)
BDBM384115
PNG
(US10280167, Example 62)
Show SMILES Nc1nc(nc2n(CCCCCCN3CCCC3)c(=O)[nH]c12)-c1nc(c[nH]1)C1CC1
Show InChI InChI=1S/C21H28N8O/c22-17-16-20(27-19(26-17)18-23-13-15(24-18)14-7-8-14)29(21(30)25-16)12-4-2-1-3-9-28-10-5-6-11-28/h13-14H,1-12H2,(H2,22,26)/b19-18+
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/an/an/a 700n/an/an/an/a



Janssen Sciences Ireland UC

US Patent


Assay Description
Activation of human TLR7 results in robust production of interferon by plasmacytoid dendritic cells present in human blood. The potential of compound...


US Patent US10280167 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%