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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM384842 (N-[(1R)-1-(4-cyclopropyl-3- fluorophenyl)-2,2-dime...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM384991 (2-(dimethylamino)-N-{(1S)-2- hydroxy-2-methyl-1-[4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 0.0730 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM384842 (N-[(1R)-1-(4-cyclopropyl-3- fluorophenyl)-2,2-dime...) | PDB GoogleScholar | UniChem | US Patent | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM384789 (US10285989, Example 2) | PDB GoogleScholar | UniChem | US Patent | 0.110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM384822 (2-(dimethylamino)-N-{(1R)-2,2- dimethyl-1-[4-(pent...) | PDB GoogleScholar | UniChem | US Patent | 0.110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM384860 (N-{(1R)-1-[4-(1,1- difluoroethyl)phenyl]-2,2- dime...) | PDB GoogleScholar | UniChem | US Patent | 0.110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM384950 (N-{(1R)-2,2-dimethyl-1-[4- (trifluoromethyl)phenyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 0.110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM384819 (N-[(1R)-1-(4-cyclopropylphenyl)-2,2- dimethylpropy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 0.110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM384821 (2-(dimethylamino)-N-{(1R)-1-[2- fluoro-4-(trifluor...) | PDB GoogleScholar | UniChem | US Patent | 0.110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM384887 (2-(dimethylamino)-N-[(1R)-2,2- dimethyl-1-{4- [(tr...) | PDB GoogleScholar | UniChem | US Patent | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM384860 (N-{(1R)-1-[4-(1,1- difluoroethyl)phenyl]-2,2- dime...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM384819 (N-[(1R)-1-(4-cyclopropylphenyl)-2,2- dimethylpropy...) | PDB GoogleScholar | UniChem | US Patent | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM384988 (2-(dimethylamino)-N-{(1S)-1-[3- fluoro-4- (trifluo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM384887 (2-(dimethylamino)-N-[(1R)-2,2- dimethyl-1-{4- [(tr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM384885 (2-(dimethylamino)-N-{(1R)-1-[3-fluoro- 4-(trifluor...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM384821 (2-(dimethylamino)-N-{(1R)-1-[2- fluoro-4-(trifluor...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM384885 (2-(dimethylamino)-N-{(1R)-1-[3-fluoro- 4-(trifluor...) | PDB GoogleScholar | UniChem | US Patent | 0.140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM384949 (N-{(1R)-2,2-dimethyl-1-[4- (trifluoromethyl)phenyl...) | PDB GoogleScholar | UniChem | US Patent | 0.140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM384822 (2-(dimethylamino)-N-{(1R)-2,2- dimethyl-1-[4-(pent...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 0.140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM384928 (N-[(1R)-2- methyl-1-{4- [(trifluoromethyl) sulfany...) | PDB GoogleScholar | UniChem | US Patent | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM384908 ((S)- or (R)-2-(dimethylamino)-N-{1-[2- fluoro-4-(p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM384789 (US10285989, Example 2) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM384949 (N-{(1R)-2,2-dimethyl-1-[4- (trifluoromethyl)phenyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 0.170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM384884 (2-(dimethylamino)-N-{(1R)-2,2- dimethyl-1-[4- (tri...) | PDB GoogleScholar | UniChem | US Patent | 0.170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM384857 (N-{(1R)-1-[4-(difluoromethyl)-2- fluorophenyl]-2,2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 0.170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM384879 (N-{(1R)-2-methyl-1-[4- (trifluoromethyl)phenyl]pro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM384886 (2-(dimethylamino)-N-{(1R)-1-[3-fluoro- 4-(trifluor...) | PDB GoogleScholar | UniChem | US Patent | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM384928 (N-[(1R)-2- methyl-1-{4- [(trifluoromethyl) sulfany...) | PDB GoogleScholar | UniChem | US Patent | 0.190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM384861 (N-{(1R)-1-[4-(1,1-difluoroethyl)-3- fluorophenyl]-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 0.190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM384875 (2-(dimethylamino)-N-{(1R)-2- methyl-1-[4- (trifluo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 0.190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM50204596 (CHEMBL3977461 | US10285989, Example 30) | PDB GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | US Patent | 0.190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM384880 (2-(dimethylamino)-N-[(1R)-1-{3- fluoro-4- [(triflu...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM384886 (2-(dimethylamino)-N-{(1R)-1-[3-fluoro- 4-(trifluor...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM384929 (2-azetidin-1-yl-N- [(1R)-2-methyl-1- {4-[(trifluor...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM384861 (N-{(1R)-1-[4-(1,1-difluoroethyl)-3- fluorophenyl]-...) | PDB GoogleScholar | UniChem | US Patent | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM384811 (N-[(R)-cyclopropyl{4- [(trifluoromethyl)sulfanyl]p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM384884 (2-(dimethylamino)-N-{(1R)-2,2- dimethyl-1-[4- (tri...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM384855 (N-[(R)-(4-cyclopropylphenyl)(1- methylcyclopropyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM384813 (N-[(1R)-1-{3-fluoro-4- [(trifluoromethyl)sulfanyl]...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 0.220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM50204596 (CHEMBL3977461 | US10285989, Example 30) | PDB GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | US Patent | 0.220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM384908 ((S)- or (R)-2-(dimethylamino)-N-{1-[2- fluoro-4-(p...) | PDB GoogleScholar | UniChem | US Patent | 0.220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM384827 (2-(dimethylamino)-N-{(R)-(1- methylcyclopropyl)[4-...) | PDB GoogleScholar | UniChem | US Patent | 0.230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM384882 (2-(dimethylamino)-N-[(1R)-1-{3- fluoro-4- [(triflu...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 0.230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM384855 (N-[(R)-(4-cyclopropylphenyl)(1- methylcyclopropyl)...) | PDB GoogleScholar | UniChem | US Patent | 0.230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM384931 (2-(dimethylamino)- N-[(1R)-1-{3- fluoro-4- [(trifl...) | PDB GoogleScholar | UniChem | US Patent | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM384928 (N-[(1R)-2- methyl-1-{4- [(trifluoromethyl) sulfany...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM384857 (N-{(1R)-1-[4-(difluoromethyl)-2- fluorophenyl]-2,2...) | PDB GoogleScholar | UniChem | US Patent | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM384896 (2-(dimethylamino)-N-{(1R)-1-[3- fluoro-4-(trifluor...) | PDB GoogleScholar | UniChem | US Patent | 0.270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM384841 (2-(dimethylamino)-N-{(R)-(1- methylcyclopropyl)[4-...) | PDB GoogleScholar | UniChem | US Patent | 0.280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM384874 (2-(dimethylamino)-N-{(1R)-1-[3- fluoro-4- (trifluo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | UniChem | US Patent | 0.280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | US Patent US10285989 (2019) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
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