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Patent code US10287253

Compile Data Set for Download or QSAR
Found 52 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385005
PNG
(3-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl)...)
Show SMILES CCCCNc1nc(N)nc(C)c1Cc1cc(ccc1OC)S(O)(=O)=O
Show InChI InChI=1S/C17H24N4O4S/c1-4-5-8-19-16-14(11(2)20-17(18)21-16)10-12-9-13(26(22,23)24)6-7-15(12)25-3/h6-7,9H,4-5,8,10H2,1-3H3,(H,22,23,24)(H3,18,19,20,21)
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n/an/an/an/a<100n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385037
PNG
((S)-3-(5-(5-((2H-tetrazol-5-yl)methyl)-2-methoxybe...)
Show SMILES CCCC[C@@H](CCSC)Nc1nc(N)nc(CCC(O)=O)c1Cc1cc(Cc2nn[nH]n2)ccc1OC
Show InChI InChI=1S/C25H36N8O3S/c1-4-5-6-18(11-12-37-3)27-24-19(20(8-10-23(34)35)28-25(26)29-24)15-17-13-16(7-9-21(17)36-2)14-22-30-32-33-31-22/h7,9,13,18H,4-6,8,10-12,14-15H2,1-3H3,(H,34,35)(H3,26,27,28,29)(H,30,31,32,33)/t18-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385025
PNG
((S)—N4-(1-(2H-tetrazol-5-yl)heptan-3-yl)-S-(2...)
Show SMILES CCCC[C@@H](CCc1nn[nH]n1)Nc1nc(N)nc(C)c1Cc1ccccc1OC
Show InChI InChI=1S/C21H30N8O/c1-4-5-9-16(11-12-19-26-28-29-27-19)24-20-17(14(2)23-21(22)25-20)13-15-8-6-7-10-18(15)30-3/h6-8,10,16H,4-5,9,11-13H2,1-3H3,(H3,22,23,24,25)(H,26,27,28,29)/t16-/m0/s1
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US Patent
n/an/an/an/a 550n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385036
PNG
(3-(2-amino-6-(butylamino)-5-(2-methoxybenzyl)pyrim...)
Show SMILES CCCCNc1nc(N)nc(CCCO)c1Cc1ccccc1OC
Show InChI InChI=1S/C19H28N4O2/c1-3-4-11-21-18-15(13-14-8-5-6-10-17(14)25-2)16(9-7-12-24)22-19(20)23-18/h5-6,8,10,24H,3-4,7,9,11-13H2,1-2H3,(H3,20,21,22,23)
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n/an/an/an/a 550n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM384878
PNG
(US10287253, Example 3)
Show SMILES CCCCNc1nc(N)nc(C)c1Cc1cc(Cc2nn[nH]n2)ccc1OC
Show InChI InChI=1S/C19H26N8O/c1-4-5-8-21-18-15(12(2)22-19(20)23-18)11-14-9-13(6-7-16(14)28-3)10-17-24-26-27-25-17/h6-7,9H,4-5,8,10-11H2,1-3H3,(H3,20,21,22,23)(H,24,25,26,27)
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US Patent
n/an/an/an/a 550n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM384924
PNG
(3-(3-((2-amino-4-(butylamino)-6-methylpyrimidin-5-...)
Show SMILES CCCCNc1nc(N)nc(C)c1Cc1cc(CCC(O)=O)ccc1OC
Show InChI InChI=1S/C20H28N4O3/c1-4-5-10-22-19-16(13(2)23-20(21)24-19)12-15-11-14(7-9-18(25)26)6-8-17(15)27-3/h6,8,11H,4-5,7,9-10,12H2,1-3H3,(H,25,26)(H3,21,22,23,24)
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n/an/an/an/a 5.50E+3n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM384995
PNG
((3-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl...)
Show SMILES CCCCNc1nc(N)nc(C)c1Cc1cc(CP(O)(O)=O)ccc1OC
Show InChI InChI=1S/C18H27N4O4P/c1-4-5-8-20-17-15(12(2)21-18(19)22-17)10-14-9-13(11-27(23,24)25)6-7-16(14)26-3/h6-7,9H,4-5,8,10-11H2,1-3H3,(H2,23,24,25)(H3,19,20,21,22)
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n/an/an/an/a 5.50E+3n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385002
PNG
(1-(3-((2-amino-4-(butylamino)-6-methylpyrimidin-5-...)
Show SMILES CCCCNc1nc(N)nc(C)c1Cc1cc(ccc1OC)C1(CC1)C(O)=O
Show InChI InChI=1S/C21H28N4O3/c1-4-5-10-23-18-16(13(2)24-20(22)25-18)12-14-11-15(6-7-17(14)28-3)21(8-9-21)19(26)27/h6-7,11H,4-5,8-10,12H2,1-3H3,(H,26,27)(H3,22,23,24,25)
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n/an/an/an/a 5.50E+3n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385006
PNG
((S)-3-((5-(5-((2H-tetrazol-5-yl)methyl)-2-methoxyb...)
Show SMILES CCCC[C@@H](CCO)Nc1nc(N)nc(C)c1Cc1cc(Cc2nn[nH]n2)ccc1OC
Show InChI InChI=1/C22H32N8O2/c1-4-5-6-17(9-10-31)25-21-18(14(2)24-22(23)26-21)13-16-11-15(7-8-19(16)32-3)12-20-27-29-30-28-20/h7-8,11,17,31H,4-6,9-10,12-13H2,1-3H3,(H3,23,24,25,26)(H,27,28,29,30)/t17-/s2
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n/an/an/an/a<100n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385012
PNG
((S)-5-(5-((2H-tetrazol-5-yl)methyl)-2-methoxybenzy...)
Show SMILES CCCC[C@@H](CCS(C)(=O)=O)Nc1nc(N)nc(C)c1Cc1cc(Cc2nn[nH]n2)ccc1OC
Show InChI InChI=1/C23H34N8O3S/c1-5-6-7-18(10-11-35(4,32)33)26-22-19(15(2)25-23(24)27-22)14-17-12-16(8-9-20(17)34-3)13-21-28-30-31-29-21/h8-9,12,18H,5-7,10-11,13-14H2,1-4H3,(H3,24,25,26,27)(H,28,29,30,31)/t18-/s2
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n/an/an/an/a<100n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385020
PNG
(5-((5-((2H-tetrazol-5-yl)methyl)-2-methoxyphenyl)t...)
Show SMILES CCCCNc1nc(N)nc(C)c1Sc1cc(Cc2nn[nH]n2)ccc1OC
Show InChI InChI=1S/C18H24N8OS/c1-4-5-8-20-17-16(11(2)21-18(19)22-17)28-14-9-12(6-7-13(14)27-3)10-15-23-25-26-24-15/h6-7,9H,4-5,8,10H2,1-3H3,(H3,19,20,21,22)(H,23,24,25,26)
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n/an/an/an/a 5.50E+3n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385032
PNG
(2-(3-((2-amino-4-(butylamino)-6-(2-carboxyethyl)py...)
Show SMILES CCCCNc1nc(N)nc(CCC(O)=O)c1Cc1cc(ccc1OC)C(C)(C)C(O)=O
Show InChI InChI=1S/C23H32N4O5/c1-5-6-11-25-20-16(17(8-10-19(28)29)26-22(24)27-20)13-14-12-15(7-9-18(14)32-4)23(2,3)21(30)31/h7,9,12H,5-6,8,10-11,13H2,1-4H3,(H,28,29)(H,30,31)(H3,24,25,26,27)
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n/an/an/an/a 5.50E+3n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385016
PNG
((S)-3-(2-amino-6-((1-hydroxyheptan-3-yl)amino)-5-(...)
Show SMILES CCCC[C@@H](CCO)Nc1nc(N)nc(CCC(O)=O)c1Cc1ccccc1OC
Show InChI InChI=1S/C22H32N4O4/c1-3-4-8-16(12-13-27)24-21-17(14-15-7-5-6-9-19(15)30-2)18(10-11-20(28)29)25-22(23)26-21/h5-7,9,16,27H,3-4,8,10-14H2,1-2H3,(H,28,29)(H3,23,24,25,26)/t16-/m0/s1
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n/an/an/an/a 550n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385018
PNG
((S)-3-((2-amino-6-(2-carboxyethyl)-5-(2-methoxyben...)
Show SMILES CCCC[C@@H](CC(O)=O)Nc1nc(N)nc(CCC(O)=O)c1Cc1ccccc1OC
Show InChI InChI=1S/C22H30N4O5/c1-3-4-8-15(13-20(29)30)24-21-16(12-14-7-5-6-9-18(14)31-2)17(10-11-19(27)28)25-22(23)26-21/h5-7,9,15H,3-4,8,10-13H2,1-2H3,(H,27,28)(H,29,30)(H3,23,24,25,26)/t15-/m0/s1
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n/an/an/an/a 550n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385021
PNG
((S)-5-(5-((2H-tetrazol-5-yl)methyl)-2-methoxybenzy...)
Show SMILES CCCC[C@@H](CCOC)Nc1nc(N)nc(C)c1Cc1cc(Cc2nn[nH]n2)ccc1OC
Show InChI InChI=1/C23H34N8O2/c1-5-6-7-18(10-11-32-3)26-22-19(15(2)25-23(24)27-22)14-17-12-16(8-9-20(17)33-4)13-21-28-30-31-29-21/h8-9,12,18H,5-7,10-11,13-14H2,1-4H3,(H3,24,25,26,27)(H,28,29,30,31)/t18-/s2
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n/an/an/an/a<100n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385026
PNG
(6-(2-(2H-tetrazol-5-yl)ethyl)-N4-butyl-5-(2-methox...)
Show SMILES CCCCNc1nc(N)nc(CCc2nn[nH]n2)c1Cc1ccccc1OC
Show InChI InChI=1S/C19H26N8O/c1-3-4-11-21-18-14(12-13-7-5-6-8-16(13)28-2)15(22-19(20)23-18)9-10-17-24-26-27-25-17/h5-8H,3-4,9-12H2,1-2H3,(H3,20,21,22,23)(H,24,25,26,27)
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n/an/an/an/a 550n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385030
PNG
((S)-3-((2-amino-5-(2-methoxybenzyl)-6-methylpyrimi...)
Show SMILES CCCC[C@@H](CC(O)=O)Nc1nc(N)nc(C)c1Cc1ccccc1OC
Show InChI InChI=1S/C20H28N4O3/c1-4-5-9-15(12-18(25)26)23-19-16(13(2)22-20(21)24-19)11-14-8-6-7-10-17(14)27-3/h6-8,10,15H,4-5,9,11-12H2,1-3H3,(H,25,26)(H3,21,22,23,24)/t15-/m0/s1
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n/an/an/an/a 550n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385033
PNG
((S)-3-((2-amino-5-(2-methoxy-S-((3-phosphonopropyl...)
Show SMILES CCCC[C@@H](CC(O)=O)Nc1nc(N)nc(C)c1Cc1cc(ccc1OC)C(=O)NCCCP(O)(O)=O
Show InChI InChI=1S/C24H36N5O7P/c1-4-5-7-18(14-21(30)31)28-22-19(15(2)27-24(25)29-22)13-17-12-16(8-9-20(17)36-3)23(32)26-10-6-11-37(33,34)35/h8-9,12,18H,4-7,10-11,13-14H2,1-3H3,(H,26,32)(H,30,31)(H2,33,34,35)(H3,25,27,28,29)/t18-/m0/s1
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n/an/an/an/a 550n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM384994
PNG
(2-(5-(3-((2-amino-4-(butylamino)-6-methylpyrimidin...)
Show SMILES CCCCNc1nc(N)nc(C)c1Cc1cc(Cc2nnnn2CC(O)=O)ccc1OC
Show InChI InChI=1S/C21H28N8O3/c1-4-5-8-23-20-16(13(2)24-21(22)25-20)11-15-9-14(6-7-17(15)32-3)10-18-26-27-28-29(18)12-19(30)31/h6-7,9H,4-5,8,10-12H2,1-3H3,(H,30,31)(H3,22,23,24,25)
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n/an/an/an/a 5.50E+3n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385003
PNG
(3-(2-amino-6-(butylamino)-5-(2-methoxybenzyl)pyrim...)
Show SMILES CCCCNc1nc(N)nc(CCC(O)=O)c1Cc1ccccc1OC
Show InChI InChI=1S/C19H26N4O3/c1-3-4-11-21-18-14(12-13-7-5-6-8-16(13)26-2)15(9-10-17(24)25)22-19(20)23-18/h5-8H,3-4,9-12H2,1-2H3,(H,24,25)(H3,20,21,22,23)
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US Patent
n/an/an/an/a 550n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385019
PNG
((3-(3-((2-amino-4-(butylamino)-6-methylpyrimidin-5...)
Show SMILES CCCCNc1nc(N)nc(C)c1Cc1cc(ccc1OC)C(=O)NCCCP(O)(O)=O
Show InChI InChI=1S/C21H32N5O5P/c1-4-5-9-23-19-17(14(2)25-21(22)26-19)13-16-12-15(7-8-18(16)31-3)20(27)24-10-6-11-32(28,29)30/h7-8,12H,4-6,9-11,13H2,1-3H3,(H,24,27)(H2,28,29,30)(H3,22,23,25,26)
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US Patent
n/an/an/an/a 550n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385038
PNG
((S)-3-(5-(5-((2H-tetrazol-5-yl)methyl)-2-methoxybe...)
Show SMILES CCCC[C@@H](CCOC)Nc1nc(N)nc(CC)c1Cc1cc(Cc2nn[nH]n2)ccc1OC
Show InChI InChI=1/C24H36N8O2/c1-5-7-8-18(11-12-33-3)26-23-19(20(6-2)27-24(25)28-23)15-17-13-16(9-10-21(17)34-4)14-22-29-31-32-30-22/h9-10,13,18H,5-8,11-12,14-15H2,1-4H3,(H3,25,26,27,28)(H,29,30,31,32)/t18-/s2
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n/an/an/an/a 550n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385039
PNG
((S)-3-(2-amino-5-(5-(carboxymethyl)-2-methoxybenzy...)
Show SMILES CCCC[C@@H](CCS(C)(=O)=O)Nc1nc(N)nc(CCC(O)=O)c1Cc1cc(CC(O)=O)ccc1OC
Show InChI InChI=1S/C25H36N4O7S/c1-4-5-6-18(11-12-37(3,34)35)27-24-19(20(8-10-22(30)31)28-25(26)29-24)15-17-13-16(14-23(32)33)7-9-21(17)36-2/h7,9,13,18H,4-6,8,10-12,14-15H2,1-3H3,(H,30,31)(H,32,33)(H3,26,27,28,29)/t18-/m0/s1
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n/an/an/an/a 550n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM384998
PNG
(5-(5-(2-(2H-tetrazol-5-yl)propan-2-yl)-2-methoxybe...)
Show SMILES CCCCNc1nc(N)nc(C)c1Cc1cc(ccc1OC)C(C)(C)c1nn[nH]n1
Show InChI InChI=1S/C21H30N8O/c1-6-7-10-23-18-16(13(2)24-20(22)25-18)12-14-11-15(8-9-17(14)30-5)21(3,4)19-26-28-29-27-19/h8-9,11H,6-7,10,12H2,1-5H3,(H3,22,23,24,25)(H,26,27,28,29)
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n/an/an/an/a 550n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385001
PNG
(5-(5-(1-(2H-tetrazol-5-yl)cyclopropyl)-2-methoxybe...)
Show SMILES CCCCNc1nc(N)nc(C)c1Cc1cc(ccc1OC)C1(CC1)c1nn[nH]n1
Show InChI InChI=1S/C21H28N8O/c1-4-5-10-23-18-16(13(2)24-20(22)25-18)12-14-11-15(6-7-17(14)30-3)21(8-9-21)19-26-28-29-27-19/h6-7,11H,4-5,8-10,12H2,1-3H3,(H3,22,23,24,25)(H,26,27,28,29)
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n/an/an/an/a 550n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385004
PNG
(2-(3-((2-amino-4-(butylamino)-6-methylpyrimidin-5-...)
Show SMILES CCCCNc1nc(N)nc(C)c1Cc1cc(ccc1OC)C(=O)NCCS(O)(=O)=O
Show InChI InChI=1S/C20H29N5O5S/c1-4-5-8-22-18-16(13(2)24-20(21)25-18)12-15-11-14(6-7-17(15)30-3)19(26)23-9-10-31(27,28)29/h6-7,11H,4-5,8-10,12H2,1-3H3,(H,23,26)(H,27,28,29)(H3,21,22,24,25)
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n/an/an/an/a 550n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385034
PNG
((S)-3-((2-amino-6-(2-carboxyethyl)-5-(5-(2-carboxy...)
Show SMILES CCCC[C@@H](CC(O)=O)Nc1nc(N)nc(CCC(O)=O)c1Cc1cc(ccc1OC)C(C)(C)C(O)=O
Show InChI InChI=1S/C26H36N4O7/c1-5-6-7-17(14-22(33)34)28-23-18(19(9-11-21(31)32)29-25(27)30-23)13-15-12-16(8-10-20(15)37-4)26(2,3)24(35)36/h8,10,12,17H,5-7,9,11,13-14H2,1-4H3,(H,31,32)(H,33,34)(H,35,36)(H3,27,28,29,30)/t17-/m0/s1
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n/an/an/an/a 5.50E+3n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385035
PNG
((S)-3-((5-(5-((2H-tetrazol-5-yl)methyl)-2-methoxyb...)
Show SMILES CCCC[C@@H](CC(O)=O)Nc1nc(N)nc(CCC(O)=O)c1Cc1cc(Cc2nn[nH]n2)ccc1OC
Show InChI InChI=1S/C24H32N8O5/c1-3-4-5-16(13-22(35)36)26-23-17(18(7-9-21(33)34)27-24(25)28-23)12-15-10-14(6-8-19(15)37-2)11-20-29-31-32-30-20/h6,8,10,16H,3-5,7,9,11-13H2,1-2H3,(H,33,34)(H,35,36)(H3,25,26,27,28)(H,29,30,31,32)/t16-/m0/s1
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n/an/an/an/a 550n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385000
PNG
((3-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl...)
Show SMILES CCCCNc1nc(N)nc(C)c1Cc1cc(ccc1OC)P(O)(O)=O
Show InChI InChI=1S/C17H25N4O4P/c1-4-5-8-19-16-14(11(2)20-17(18)21-16)10-12-9-13(26(22,23)24)6-7-15(12)25-3/h6-7,9H,4-5,8,10H2,1-3H3,(H2,22,23,24)(H3,18,19,20,21)
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n/an/an/an/a 550n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385007
PNG
(3-(2-amino-6-(butylamino)-5-(4-methoxyphenethyl)py...)
Show SMILES CCCCNc1nc(N)nc(CCC(O)=O)c1CCc1ccc(OC)cc1
Show InChI InChI=1S/C20H28N4O3/c1-3-4-13-22-19-16(10-7-14-5-8-15(27-2)9-6-14)17(11-12-18(25)26)23-20(21)24-19/h5-6,8-9H,3-4,7,10-13H2,1-2H3,(H,25,26)(H3,21,22,23,24)
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n/an/an/an/a 5.50E+3n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385009
PNG
((R)-3-((5-(5-((2H-tetrazol-5-yl)methyl)-2-methoxyb...)
Show SMILES CCCC[C@H](CC(O)=O)Nc1nc(N)nc(C)c1Cc1cc(Cc2nn[nH]n2)ccc1OC
Show InChI InChI=1/C22H30N8O3/c1-4-5-6-16(12-20(31)32)25-21-17(13(2)24-22(23)26-21)11-15-9-14(7-8-18(15)33-3)10-19-27-29-30-28-19/h7-9,16H,4-6,10-12H2,1-3H3,(H,31,32)(H3,23,24,25,26)(H,27,28,29,30)/t16-/s2
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n/an/an/an/a 5.50E+3n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385010
PNG
((S)-3-(2-amino-6-((1-hydroxyheptan-3-yl)amino)-5-m...)
Show SMILES CCCC[C@@H](CCO)Nc1nc(N)nc(CCC(O)=O)c1OC
Show InChI InChI=1S/C15H26N4O4/c1-3-4-5-10(8-9-20)17-14-13(23-2)11(6-7-12(21)22)18-15(16)19-14/h10,20H,3-9H2,1-2H3,(H,21,22)(H3,16,17,18,19)/t10-/m0/s1
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n/an/an/an/a 5.50E+3n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385015
PNG
(5-(5-((2H-tetrazol-5-yl)methyl)-2-methoxybenzyl)-6...)
Show SMILES CCCCCNc1nc(N)nc(C)c1Cc1cc(Cc2nn[nH]n2)ccc1OC
Show InChI InChI=1S/C20H28N8O/c1-4-5-6-9-22-19-16(13(2)23-20(21)24-19)12-15-10-14(7-8-17(15)29-3)11-18-25-27-28-26-18/h7-8,10H,4-6,9,11-12H2,1-3H3,(H3,21,22,23,24)(H,25,26,27,28)
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n/an/an/an/a 550n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385023
PNG
((S)-5-(2-methoxy-5-(2H-tetrazol-5-yl)benzyl)-6-met...)
Show SMILES CCCC[C@@H](CCSC)Nc1nc(N)nc(C)c1Cc1cc(ccc1OC)-c1nn[nH]n1
Show InChI InChI=1S/C22H32N8OS/c1-5-6-7-17(10-11-32-4)25-21-18(14(2)24-22(23)26-21)13-16-12-15(8-9-19(16)31-3)20-27-29-30-28-20/h8-9,12,17H,5-7,10-11,13H2,1-4H3,(H3,23,24,25,26)(H,27,28,29,30)/t17-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385028
PNG
(5-(5-((2H-tetrazol-5-yl)methyl)-2-methoxybenzyl)-6...)
Show SMILES CCCC(C)Nc1nc(N)nc(C)c1Cc1cc(Cc2nn[nH]n2)ccc1OC
Show InChI InChI=1/C20H28N8O/c1-5-6-12(2)22-19-16(13(3)23-20(21)24-19)11-15-9-14(7-8-17(15)29-4)10-18-25-27-28-26-18/h7-9,12H,5-6,10-11H2,1-4H3,(H3,21,22,23,24)(H,25,26,27,28)
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n/an/an/an/a 550n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385029
PNG
(3-(5-(5-((2H-tetrazol-5-yl)methyl)-2-methoxybenzyl...)
Show SMILES CCCCNc1nc(N)nc(CCC(O)=O)c1Cc1cc(Cc2nn[nH]n2)ccc1OC
Show InChI InChI=1S/C21H28N8O3/c1-3-4-9-23-20-15(16(6-8-19(30)31)24-21(22)25-20)12-14-10-13(5-7-17(14)32-2)11-18-26-28-29-27-18/h5,7,10H,3-4,6,8-9,11-12H2,1-2H3,(H,30,31)(H3,22,23,24,25)(H,26,27,28,29)
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n/an/an/an/a 550n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385031
PNG
((S)-3-((2-amino-5-(5-(2-carboxypropan-2-yl)-2-meth...)
Show SMILES CCCC[C@@H](CC(O)=O)Nc1nc(N)nc(C)c1Cc1cc(ccc1OC)C(C)(C)C(O)=O
Show InChI InChI=1S/C24H34N4O5/c1-6-7-8-17(13-20(29)30)27-21-18(14(2)26-23(25)28-21)12-15-11-16(9-10-19(15)33-5)24(3,4)22(31)32/h9-11,17H,6-8,12-13H2,1-5H3,(H,29,30)(H,31,32)(H3,25,26,27,28)/t17-/m0/s1
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n/an/an/an/a 550n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385040
PNG
(US10287253, Example 51A)
Show SMILES CCCC[C@@H](CCS(C)(=O)=O)Nc1nc(N)nc(C)c1Cc1cc(CC(O)=O)ccc1OC
Show InChI InChI=1S/C23H34N4O5S/c1-5-6-7-18(10-11-33(4,30)31)26-22-19(15(2)25-23(24)27-22)14-17-12-16(13-21(28)29)8-9-20(17)32-3/h8-9,12,18H,5-7,10-11,13-14H2,1-4H3,(H,28,29)(H3,24,25,26,27)/t18-/m0/s1
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n/an/an/an/a 550n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM384814
PNG
(3-(4-((2-amino-4-(butylamino)-6-methylpyrimidin-5-...)
Show SMILES CCCCNc1nc(N)nc(C)c1Cc1ccc(CCC(O)=O)cc1OC
Show InChI InChI=1S/C20H28N4O3/c1-4-5-10-22-19-16(13(2)23-20(21)24-19)12-15-8-6-14(7-9-18(25)26)11-17(15)27-3/h6,8,11H,4-5,7,9-10,12H2,1-3H3,(H,25,26)(H3,21,22,23,24)
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n/an/an/an/a 5.50E+3n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM384872
PNG
(5-(4-((2H-tetrazol-5-yl)methyl)-2-methoxybenzyl)-N...)
Show SMILES CCCCNc1nc(N)nc(C)c1Cc1ccc(Cc2nn[nH]n2)cc1OC
Show InChI InChI=1S/C19H26N8O/c1-4-5-8-21-18-15(12(2)22-19(20)23-18)11-14-7-6-13(9-16(14)28-3)10-17-24-26-27-25-17/h6-7,9H,4-5,8,10-11H2,1-3H3,(H3,20,21,22,23)(H,24,25,26,27)
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n/an/an/an/a 5.50E+3n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM384993
PNG
(2-(5-(3-((2-amino-4-(butylamino)-6-methylpyrimidin...)
Show SMILES CCCCNc1nc(N)nc(C)c1Cc1cc(Cc2nnn(CC(O)=O)n2)ccc1OC
Show InChI InChI=1S/C21H28N8O3/c1-4-5-8-23-20-16(13(2)24-21(22)25-20)11-15-9-14(6-7-17(15)32-3)10-18-26-28-29(27-18)12-19(30)31/h6-7,9H,4-5,8,10-12H2,1-3H3,(H,30,31)(H3,22,23,24,25)
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n/an/an/an/a 5.50E+3n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM384996
PNG
((S)-2-((5-(5-((2H-tetrazol-5-yl)methyl)-2-methoxyb...)
Show SMILES CCC[C@@H](CO)Nc1nc(N)nc(C)c1Cc1cc(Cc2nn[nH]n2)ccc1OC
Show InChI InChI=1/C20H28N8O2/c1-4-5-15(11-29)23-19-16(12(2)22-20(21)24-19)10-14-8-13(6-7-17(14)30-3)9-18-25-27-28-26-18/h6-8,15,29H,4-5,9-11H2,1-3H3,(H3,21,22,23,24)(H,25,26,27,28)/t15-/s2
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n/an/an/an/a 550n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM384999
PNG
(N4-butyl-5-(2-methoxy-5-(2H-tetrazol-5-yl)benzyl)-...)
Show SMILES CCCCNc1nc(N)nc(C)c1Cc1cc(ccc1OC)-c1nn[nH]n1
Show InChI InChI=1S/C18H24N8O/c1-4-5-8-20-17-14(11(2)21-18(19)22-17)10-13-9-12(6-7-15(13)27-3)16-23-25-26-24-16/h6-7,9H,4-5,8,10H2,1-3H3,(H3,19,20,21,22)(H,23,24,25,26)
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n/an/an/an/a 550n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385008
PNG
((S)-3-((5-(5-((2H-tetrazol-5-yl)methyl)-2-methoxyb...)
Show SMILES CCCC[C@@H](CC(O)=O)Nc1nc(N)nc(C)c1Cc1cc(Cc2nn[nH]n2)ccc1OC
Show InChI InChI=1S/C22H30N8O3/c1-4-5-6-16(12-20(31)32)25-21-17(13(2)24-22(23)26-21)11-15-9-14(7-8-18(15)33-3)10-19-27-29-30-28-19/h7-9,16H,4-6,10-12H2,1-3H3,(H,31,32)(H3,23,24,25,26)(H,27,28,29,30)/t16-/m0/s1
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n/an/an/an/a 550n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385011
PNG
((S)-5-(5-((2H-tetrazol-5-yl)methyl)-2-methoxybenzy...)
Show SMILES CCCC[C@@H](CCSC)Nc1nc(N)nc(C)c1Cc1cc(Cc2nn[nH]n2)ccc1OC
Show InChI InChI=1S/C23H34N8OS/c1-5-6-7-18(10-11-33-4)26-22-19(15(2)25-23(24)27-22)14-17-12-16(8-9-20(17)32-3)13-21-28-30-31-29-21/h8-9,12,18H,5-7,10-11,13-14H2,1-4H3,(H3,24,25,26,27)(H,28,29,30,31)/t18-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385013
PNG
((3-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl...)
Show SMILES CCCCNc1nc(N)nc(C)c1Cc1cc(ccc1OC)B(O)O
Show InChI InChI=1S/C17H25BN4O3/c1-4-5-8-20-16-14(11(2)21-17(19)22-16)10-12-9-13(18(23)24)6-7-15(12)25-3/h6-7,9,23-24H,4-5,8,10H2,1-3H3,(H3,19,20,21,22)
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n/an/an/an/a<100n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385016
PNG
((S)-3-(2-amino-6-((1-hydroxyheptan-3-yl)amino)-5-(...)
Show SMILES CCCC[C@@H](CCO)Nc1nc(N)nc(CCC(O)=O)c1Cc1ccccc1OC
Show InChI InChI=1S/C22H32N4O4/c1-3-4-8-16(12-13-27)24-21-17(14-15-7-5-6-9-19(15)30-2)18(10-11-20(28)29)25-22(23)26-21/h5-7,9,16,27H,3-4,8,10-14H2,1-2H3,(H,28,29)(H3,23,24,25,26)/t16-/m0/s1
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n/an/an/an/a 5.50E+3n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385022
PNG
((S)-2-(3-((2-amino-4-methyl-6-((1-(methylthio)hept...)
Show SMILES CCCC[C@@H](CCSC)Nc1nc(N)nc(C)c1Cc1cc(ccc1OC)C(C)(C)C(O)=O
Show InChI InChI=1S/C25H38N4O3S/c1-7-8-9-19(12-13-33-6)28-22-20(16(2)27-24(26)29-22)15-17-14-18(10-11-21(17)32-5)25(3,4)23(30)31/h10-11,14,19H,7-9,12-13,15H2,1-6H3,(H,30,31)(H3,26,27,28,29)/t19-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385024
PNG
((S)-(3-(3-((2-amino-4-methyl-6-((1-(methylthio)hep...)
Show SMILES CCCC[C@@H](CCSC)Nc1nc(N)nc(C)c1Cc1cc(ccc1OC)C(=O)NCCCP(O)(O)=O
Show InChI InChI=1S/C25H40N5O5PS/c1-5-6-8-20(11-14-37-4)29-23-21(17(2)28-25(26)30-23)16-19-15-18(9-10-22(19)35-3)24(31)27-12-7-13-36(32,33)34/h9-10,15,20H,5-8,11-14,16H2,1-4H3,(H,27,31)(H2,32,33,34)(H3,26,28,29,30)/t20-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM384997
PNG
(2-(3-((2-amino-4-(butylamino)-6-methylpyrimidin-5-...)
Show SMILES CCCCNc1nc(N)nc(C)c1Cc1cc(ccc1OC)C(C)(C)C(O)=O
Show InChI InChI=1S/C21H30N4O3/c1-6-7-10-23-18-16(13(2)24-20(22)25-18)12-14-11-15(8-9-17(14)28-5)21(3,4)19(26)27/h8-9,11H,6-7,10,12H2,1-5H3,(H,26,27)(H3,22,23,24,25)
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n/an/an/an/a 550n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385027
PNG
((S)-3-(2-amino-5-(2-methoxybenzyl)-6-((1-(methylth...)
Show SMILES CCCC[C@@H](CCSC)Nc1nc(N)nc(CCC(O)=O)c1Cc1ccccc1OC
Show InChI InChI=1S/C23H34N4O3S/c1-4-5-9-17(13-14-31-3)25-22-18(15-16-8-6-7-10-20(16)30-2)19(11-12-21(28)29)26-23(24)27-22/h6-8,10,17H,4-5,9,11-15H2,1-3H3,(H,28,29)(H3,24,25,26,27)/t17-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM385014
PNG
(4-(3-((2-amino-4-(butylamino)-6-methylpyrimidin-5-...)
Show SMILES CCCCNc1nc(N)nc(C)c1Cc1cc(ccc1OC)C(=O)NCCCC(O)=O
Show InChI InChI=1S/C22H31N5O4/c1-4-5-10-24-20-17(14(2)26-22(23)27-20)13-16-12-15(8-9-18(16)31-3)21(30)25-11-6-7-19(28)29/h8-9,12H,4-7,10-11,13H2,1-3H3,(H,25,30)(H,28,29)(H3,23,24,26,27)
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n/an/an/an/a 550n/an/an/an/a



APROS THERAPEUTICS, INC.

US Patent


Assay Description
HEK-Blue TLR7 cells were purchased from Invivogen (San Diego, Calif.). The following description was taken from the product information sheet."HEK-Bl...


US Patent US10287253 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%