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Patent code US10287274

Compile Data Set for Download or QSAR
Found 43 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352210
PNG
(US10239868, Entry 14 | US10287274, Entry 14 | US98...)
Show SMILES CCC1(CC)CC(CCN2CCN(CC2)c2ccccc2C(C)C)OC1=O
Show InChI InChI=1/C23H36N2O2/c1-5-23(6-2)17-19(27-22(23)26)11-12-24-13-15-25(16-14-24)21-10-8-7-9-20(21)18(3)4/h7-10,18-19H,5-6,11-17H2,1-4H3
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n/an/a 6n/an/an/an/an/an/a



TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352200
PNG
(US10239868, Entry 4 | US10287274, Entry 4 | US9802...)
Show SMILES CCC1(CC)CC(CCN2CCN(CC2)c2ccc(C)cc2)OC1=O
Show InChI InChI=1/C21H32N2O2/c1-4-21(5-2)16-19(25-20(21)24)10-11-22-12-14-23(15-13-22)18-8-6-17(3)7-9-18/h6-9,19H,4-5,10-16H2,1-3H3
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n/an/a 10n/an/an/an/an/an/a



TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352214
PNG
(US10239868, Entry 18 | US10287274, Entry 18 | US98...)
Show SMILES CCC1(CC)CC(CCN2CCc3ccccc3C2)OC1=O
Show InChI InChI=1/C19H27NO2/c1-3-19(4-2)13-17(22-18(19)21)10-12-20-11-9-15-7-5-6-8-16(15)14-20/h5-8,17H,3-4,9-14H2,1-2H3
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TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352240
PNG
(US10239868, Entry 42 | US10287274, Entry 42 | US98...)
Show SMILES O=C1OC(CCN2CCN(CC2)c2ccccc2N2CCOCC2)CC11CCCC1
Show InChI InChI=1/C24H35N3O3/c28-23-24(8-3-4-9-24)19-20(30-23)7-10-25-11-13-26(14-12-25)21-5-1-2-6-22(21)27-15-17-29-18-16-27/h1-2,5-6,20H,3-4,7-19H2
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n/an/a 17n/an/an/an/an/an/a



TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352207
PNG
(US10239868, Entry 11 | US10287274, Entry 11 | US98...)
Show SMILES CCC1(CC)CC(CCN2CCN(CC2)c2ccccc2)OC1=O
Show InChI InChI=1/C20H30N2O2/c1-3-20(4-2)16-18(24-19(20)23)10-11-21-12-14-22(15-13-21)17-8-6-5-7-9-17/h5-9,18H,3-4,10-16H2,1-2H3
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n/an/a 21n/an/an/an/an/an/a



TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352238
PNG
(US10239868, Entry 39 | US10287274, Entry 39 | US98...)
Show SMILES CC(C)c1ccccc1N1CCN(CCC2CC3(CCCC3)C(=O)O2)CC1
Show InChI InChI=1/C23H34N2O2/c1-18(2)20-7-3-4-8-21(20)25-15-13-24(14-16-25)12-9-19-17-23(22(26)27-19)10-5-6-11-23/h3-4,7-8,18-19H,5-6,9-17H2,1-2H3
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TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352235
PNG
(US10239868, Entry 36 | US10287274, Entry 36 | US98...)
Show SMILES Clc1ccc(nc1)N1CCN(CCC2CC3(CCCCC3)C(=O)O2)CC1
Show InChI InChI=1/C20H28ClN3O2/c21-16-4-5-18(22-15-16)24-12-10-23(11-13-24)9-6-17-14-20(19(25)26-17)7-2-1-3-8-20/h4-5,15,17H,1-3,6-14H2
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n/an/a 33n/an/an/an/an/an/a



TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352218
PNG
(US10239868, Entry 22 | US10287274, Entry 22 | US98...)
Show SMILES O=C1OC(CCN2CCN(CC2)c2ccccc2)CC11CCCCC1
Show InChI InChI=1/C21H30N2O2/c24-20-21(10-5-2-6-11-21)17-19(25-20)9-12-22-13-15-23(16-14-22)18-7-3-1-4-8-18/h1,3-4,7-8,19H,2,5-6,9-17H2
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TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352224
PNG
(US10239868, Entry 28 | US10287274, Entry 28 | US98...)
Show SMILES Clc1ccc(cc1)N1CCN(CCC2CC3(CCCCC3)C(=O)O2)CC1
Show InChI InChI=1/C21H29ClN2O2/c22-17-4-6-18(7-5-17)24-14-12-23(13-15-24)11-8-19-16-21(20(25)26-19)9-2-1-3-10-21/h4-7,19H,1-3,8-16H2
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TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352222
PNG
(US10239868, Entry 26 | US10287274, Entry 26 | US98...)
Show SMILES O=C1OC(CCN2CCN(CC2)c2ccccn2)CC11CCCCC1
Show InChI InChI=1/C20H29N3O2/c24-19-20(8-3-1-4-9-20)16-17(25-19)7-11-22-12-14-23(15-13-22)18-6-2-5-10-21-18/h2,5-6,10,17H,1,3-4,7-9,11-16H2
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TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352205
PNG
(US10239868, Entry 9 | US10287274, Entry 9 | US9802...)
Show SMILES CCC1(CC)CC(CCN2CCN(CC2)c2ccccn2)OC1=O
Show InChI InChI=1/C19H29N3O2/c1-3-19(4-2)15-16(24-18(19)23)8-10-21-11-13-22(14-12-21)17-7-5-6-9-20-17/h5-7,9,16H,3-4,8,10-15H2,1-2H3
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TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352221
PNG
(US10239868, Entry 25 | US10287274, Entry 25 | US98...)
Show SMILES Oc1ccccc1N1CCN(CCC2CC3(CCCCC3)C(=O)O2)CC1
Show InChI InChI=1/C21H30N2O3/c24-19-7-3-2-6-18(19)23-14-12-22(13-15-23)11-8-17-16-21(20(25)26-17)9-4-1-5-10-21/h2-3,6-7,17,24H,1,4-5,8-16H2
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TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352198
PNG
(US10239868, Entry 2 | US10287274, Entry 2 | US9802...)
Show SMILES CCC1(CC)CC(CCN2CCN(CC2)c2ccc(cc2)[N+]([O-])=O)OC1=O
Show InChI InChI=1/C20H29N3O4/c1-3-20(4-2)15-18(27-19(20)24)9-10-21-11-13-22(14-12-21)16-5-7-17(8-6-16)23(25)26/h5-8,18H,3-4,9-15H2,1-2H3
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TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352219
PNG
(US10239868, Entry 23 | US10287274, Entry 23 | US98...)
Show SMILES COc1cccc(c1)N1CCN(CCC2CC3(CCCCC3)C(=O)O2)CC1
Show InChI InChI=1/C22H32N2O3/c1-26-19-7-5-6-18(16-19)24-14-12-23(13-15-24)11-8-20-17-22(21(25)27-20)9-3-2-4-10-22/h5-7,16,20H,2-4,8-15,17H2,1H3
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TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352220
PNG
(US10239868, Entry 24 | US10287274, Entry 24 | US98...)
Show SMILES COc1ccccc1N1CCN(CCC2CC3(CCCCC3)C(=O)O2)CC1
Show InChI InChI=1/C22H32N2O3/c1-26-20-8-4-3-7-19(20)24-15-13-23(14-16-24)12-9-18-17-22(21(25)27-18)10-5-2-6-11-22/h3-4,7-8,18H,2,5-6,9-17H2,1H3
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TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352215
PNG
(US10287274, Entry 19 | US9802924, Entry 19)
Show SMILES CC1(C)CC(CCN2CCN(CC2)c2ccccc2C#N)OC1=O
Show InChI InChI=1/C19H25N3O2/c1-19(2)13-16(24-18(19)23)7-8-21-9-11-22(12-10-21)17-6-4-3-5-15(17)14-20/h3-6,16H,7-13H2,1-2H3
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TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352237
PNG
(US10239868, Entry 38 | US10287274, Entry 38 | US98...)
Show SMILES CCC1(CC)CC(CCN2CCC(CC2)=C(c2ccccc2)c2ccccc2)OC1=O
Show InChI InChI=1/C28H35NO2/c1-3-28(4-2)21-25(31-27(28)30)17-20-29-18-15-24(16-19-29)26(22-11-7-5-8-12-22)23-13-9-6-10-14-23/h5-14,25H,3-4,15-21H2,1-2H3
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TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352223
PNG
(US10239868, Entry 27 | US10287274, Entry 27 | US98...)
Show SMILES Clc1ccccc1N1CCN(CCC2CC3(CCCCC3)C(=O)O2)CC1
Show InChI InChI=1/C21H29ClN2O2/c22-18-6-2-3-7-19(18)24-14-12-23(13-15-24)11-8-17-16-21(20(25)26-17)9-4-1-5-10-21/h2-3,6-7,17H,1,4-5,8-16H2
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TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352211
PNG
(US10239868, Entry 15 | US10287274, Entry 15 | US98...)
Show SMILES CCC1(CC)CC(CCN2CCN(CC2)C(c2ccccc2)c2ccccc2)OC1=O
Show InChI InChI=1/C27H36N2O2/c1-3-27(4-2)21-24(31-26(27)30)15-16-28-17-19-29(20-18-28)25(22-11-7-5-8-12-22)23-13-9-6-10-14-23/h5-14,24-25H,3-4,15-21H2,1-2H3
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TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352197
PNG
(US10239868, Entry 1 | US10287274, Entry 1 | US9802...)
Show SMILES CCC1(CC)CC(CCN2CCN(CC2)c2ccc(O)cc2)OC1=O
Show InChI InChI=1/C20H30N2O3/c1-3-20(4-2)15-18(25-19(20)24)9-10-21-11-13-22(14-12-21)16-5-7-17(23)8-6-16/h5-8,18,23H,3-4,9-15H2,1-2H3
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TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352226
PNG
(US10239868, Entry 31 | US10287274, Entry 31 | US98...)
Show SMILES Oc1ccc(cc1)N1CCN(CCC2CC3(CCCCC3)C(=O)O2)CC1
Show InChI InChI=1/C21H30N2O3/c24-18-6-4-17(5-7-18)23-14-12-22(13-15-23)11-8-19-16-21(20(25)26-19)9-2-1-3-10-21/h4-7,19,24H,1-3,8-16H2
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TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352212
PNG
(US10239868, Entry 16 | US10287274, Entry 16 | US98...)
Show SMILES CCC1(CC)CC(CCN2CCN(CC2)c2ccccc2C)OC1=O
Show InChI InChI=1/C21H32N2O2/c1-4-21(5-2)16-18(25-20(21)24)10-11-22-12-14-23(15-13-22)19-9-7-6-8-17(19)3/h6-9,18H,4-5,10-16H2,1-3H3
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TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352241
PNG
(US10239868, Entry 43 | US10287274, Entry 43 | US98...)
Show SMILES CCC1(CC)CC(CCN2CCN(CC2)c2ccccc2OC)OC1=O
Show InChI InChI=1/C21H32N2O3/c1-4-21(5-2)16-17(26-20(21)24)10-11-22-12-14-23(15-13-22)18-8-6-7-9-19(18)25-3/h6-9,17H,4-5,10-16H2,1-3H3
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n/an/a 118n/an/an/an/an/an/a



TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352199
PNG
(US10239868, Entry 3 | US10287274, Entry 3 | US9802...)
Show SMILES CCC1(CC)CC(CCN2CCN(CC2)c2ccc(cc2)C#N)OC1=O
Show InChI InChI=1/C21H29N3O2/c1-3-21(4-2)15-19(26-20(21)25)9-10-23-11-13-24(14-12-23)18-7-5-17(16-22)6-8-18/h5-8,19H,3-4,9-15H2,1-2H3
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n/an/a 134n/an/an/an/an/an/a



TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352242
PNG
(US10239868, Entry 45 | US10287274, Entry 45 | US98...)
Show SMILES Cc1ccc(cc1)N1CCN(CCC2CC(C(=O)O2)(c2ccccc2)c2ccccc2)CC1
Show InChI InChI=1/C29H32N2O2/c1-23-12-14-26(15-13-23)31-20-18-30(19-21-31)17-16-27-22-29(28(32)33-27,24-8-4-2-5-9-24)25-10-6-3-7-11-25/h2-15,27H,16-22H2,1H3
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n/an/a 145n/an/an/an/an/an/a



TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352243
PNG
(US10239868, Entry 46 | US10287274, Entry 46 | US98...)
Show SMILES Cc1ccc(cc1)N1CCN(CCCC2CC(C(=O)O2)(c2ccccc2)c2ccccc2)CC1
Show InChI InChI=1/C30H34N2O2/c1-24-14-16-27(17-15-24)32-21-19-31(20-22-32)18-8-13-28-23-30(29(33)34-28,25-9-4-2-5-10-25)26-11-6-3-7-12-26/h2-7,9-12,14-17,28H,8,13,18-23H2,1H3
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n/an/a 146n/an/an/an/an/an/a



TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352202
PNG
(US10239868, Entry 6 | US10287274, Entry 6 | US9802...)
Show SMILES CCC1(CC)CC(CCN2CCN(CC2)c2ccccc2O)OC1=O
Show InChI InChI=1/C20H30N2O3/c1-3-20(4-2)15-16(25-19(20)24)9-10-21-11-13-22(14-12-21)17-7-5-6-8-18(17)23/h5-8,16,23H,3-4,9-15H2,1-2H3
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n/an/a 156n/an/an/an/an/an/a



TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352203
PNG
(US10239868, Entry 7 | US10287274, Entry 7 | US9802...)
Show SMILES CCC1(CC)CC(CCN2CCN(CC2)c2cccc(OC)c2)OC1=O
Show InChI InChI=1/C21H32N2O3/c1-4-21(5-2)16-19(26-20(21)24)9-10-22-11-13-23(14-12-22)17-7-6-8-18(15-17)25-3/h6-8,15,19H,4-5,9-14,16H2,1-3H3
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n/an/a 165n/an/an/an/an/an/a



TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352225
PNG
(US10239868, Entry 29 | US10287274, Entry 29 | US98...)
Show SMILES FC(F)(F)c1ccc(cc1)N1CCN(CCC2CC3(CCCCC3)C(=O)O2)CC1
Show InChI InChI=1/C22H29F3N2O2/c23-22(24,25)17-4-6-18(7-5-17)27-14-12-26(13-15-27)11-8-19-16-21(20(28)29-19)9-2-1-3-10-21/h4-7,19H,1-3,8-16H2
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n/an/a 183n/an/an/an/an/an/a



TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352217
PNG
(US10239868, Entry 21 | US10287274, Entry 21 | US98...)
Show SMILES Oc1cccc(c1)N1CCN(CCC2CC3(CCCCC3)C(=O)O2)CC1
Show InChI InChI=1/C21H30N2O3/c24-18-6-4-5-17(15-18)23-13-11-22(12-14-23)10-7-19-16-21(20(25)26-19)8-2-1-3-9-21/h4-6,15,19,24H,1-3,7-14,16H2
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TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352234
PNG
(US10239868, Entry 35 | US10287274, Entry 35 | US98...)
Show SMILES FC(F)(F)c1ccc(nc1)N1CCN(CCC2CC3(CCCCC3)C(=O)O2)CC1
Show InChI InChI=1/C21H28F3N3O2/c22-21(23,24)16-4-5-18(25-15-16)27-12-10-26(11-13-27)9-6-17-14-20(19(28)29-17)7-2-1-3-8-20/h4-5,15,17H,1-3,6-14H2
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n/an/a 254n/an/an/an/an/an/a



TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352204
PNG
(US10239868, Entry 8 | US10287274, Entry 8 | US9802...)
Show SMILES CCC1(CC)CC(CCN2CCN(CC2)c2cccc(O)c2)OC1=O
Show InChI InChI=1/C20H30N2O3/c1-3-20(4-2)15-18(25-19(20)24)8-9-21-10-12-22(13-11-21)16-6-5-7-17(23)14-16/h5-7,14,18,23H,3-4,8-13,15H2,1-2H3
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n/an/a 324n/an/an/an/an/an/a



TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352213
PNG
(US10239868, Entry 17 | US10287274, Entry 17 | US98...)
Show SMILES CCC1(CC)CC(CCN2CCN(CC2)c2ccc(C)cc2C)OC1=O
Show InChI InChI=1/C22H34N2O2/c1-5-22(6-2)16-19(26-21(22)25)9-10-23-11-13-24(14-12-23)20-8-7-17(3)15-18(20)4/h7-8,15,19H,5-6,9-14,16H2,1-4H3
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n/an/a 363n/an/an/an/an/an/a



TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352228
PNG
(US10239868, Entry 33 | US10287274, Entry 33 | US98...)
Show SMILES O=C1OC(CCN2CCN(CC2)c2ccc(cc2)C#N)CC11CCCCC1
Show InChI InChI=1/C22H29N3O2/c23-17-18-4-6-19(7-5-18)25-14-12-24(13-15-25)11-8-20-16-22(21(26)27-20)9-2-1-3-10-22/h4-7,20H,1-3,8-16H2
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n/an/a 402n/an/an/an/an/an/a



TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352208
PNG
(US10239868, Entry 12 | US10287274, Entry 12 | US98...)
Show SMILES CCC1(CC)CC(CCN2CCN(CC2)c2ccc(N)cc2)OC1=O
Show InChI InChI=1/C20H31N3O2/c1-3-20(4-2)15-18(25-19(20)24)9-10-22-11-13-23(14-12-22)17-7-5-16(21)6-8-17/h5-8,18H,3-4,9-15,21H2,1-2H3
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TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352201
PNG
(US10239868, Entry 5 | US10287274, Entry 5 | US9802...)
Show SMILES CCC1(CC)CC(CCN2CCN(CCc3ccccc3)CC2)OC1=O
Show InChI InChI=1/C22H34N2O2/c1-3-22(4-2)18-20(26-21(22)25)11-13-24-16-14-23(15-17-24)12-10-19-8-6-5-7-9-19/h5-9,20H,3-4,10-18H2,1-2H3
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TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352227
PNG
(US10239868, Entry 32 | US10287274, Entry 32 | US98...)
Show SMILES O=C1OC(CCN2CCN(CC2)c2cccnc2)CC11CCCCC1
Show InChI InChI=1/C20H29N3O2/c24-19-20(7-2-1-3-8-20)15-18(25-19)6-10-22-11-13-23(14-12-22)17-5-4-9-21-16-17/h4-5,9,16,18H,1-3,6-8,10-15H2
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n/an/a 749n/an/an/an/an/an/a



TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352216
PNG
(US10239868, Entry 20 | US10287274, Entry 20 | US98...)
Show SMILES COc1ccc(cc1)N1CCN(CCC2CC3(CCCCC3)C(=O)O2)CC1
Show InChI InChI=1/C22H32N2O3/c1-26-19-7-5-18(6-8-19)24-15-13-23(14-16-24)12-9-20-17-22(21(25)27-20)10-3-2-4-11-22/h5-8,20H,2-4,9-17H2,1H3
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n/an/a 898n/an/an/an/an/an/a



TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352206
PNG
(US10239868, Entry 10 | US10287274, Entry 10 | US98...)
Show SMILES CCC1(CC)CC(CCN2CCN(CC2)c2c(C)cccc2C)OC1=O
Show InChI InChI=1/C22H34N2O2/c1-5-22(6-2)16-19(26-21(22)25)10-11-23-12-14-24(15-13-23)20-17(3)8-7-9-18(20)4/h7-9,19H,5-6,10-16H2,1-4H3
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n/an/a 1.38E+3n/an/an/an/an/an/a



TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352229
PNG
(US10239868, Entry 34 | US10287274, Entry 34 | US98...)
Show SMILES O=C1OC(CCN2CCN(CC2)c2ccc(cn2)C#N)CC11CCCCC1
Show InChI InChI=1/C21H28N4O2/c22-15-17-4-5-19(23-16-17)25-12-10-24(11-13-25)9-6-18-14-21(20(26)27-18)7-2-1-3-8-21/h4-5,16,18H,1-3,6-14H2
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n/an/a 1.52E+3n/an/an/an/an/an/a



TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352239
PNG
(US10239868, Entry 40 | US10287274, Entry 40 | US98...)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CCC2CC3(CCCC3)C(=O)O2)CC1
Show InChI InChI=1/C24H36N2O2/c1-23(2,3)20-8-4-5-9-21(20)26-16-14-25(15-17-26)13-10-19-18-24(22(27)28-19)11-6-7-12-24/h4-5,8-9,19H,6-7,10-18H2,1-3H3
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n/an/a 1.92E+3n/an/an/an/an/an/a



TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM371610
PNG
(US10239868, Entry 37 | US10287274, Entry 37)
Show SMILES CCC1(CC)CC(CCN2CCC(CC2)C(O)(c2ccccc2)c2ccccc2)OC1=O
Show InChI InChI=1/C28H37NO3/c1-3-27(4-2)21-25(32-26(27)30)17-20-29-18-15-24(16-19-29)28(31,22-11-7-5-8-12-22)23-13-9-6-10-14-23/h5-14,24-25,31H,3-4,15-21H2,1-2H3
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n/an/a 3.16E+3n/an/an/an/an/an/a



TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))		BDBM352209
PNG
(US10239868, Entry 13 | US10287274, Entry 13 | US98...)
Show SMILES CCC1(CC)CC(CCN2CCN(CC2)C2CCCCC2)OC1=O
Show InChI InChI=1/C20H36N2O2/c1-3-20(4-2)16-18(24-19(20)23)10-11-21-12-14-22(15-13-21)17-8-6-5-7-9-17/h17-18H,3-16H2,1-2H3
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n/an/a 3.76E+3n/an/an/an/an/an/a



TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer or DMSO according to its solubility. A simil...

US Patent US10287274 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%