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Patent code US10287279

Compile Data Set for Download or QSAR
Found 42 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385580
PNG
(US10287279, Compound 22)
Show SMILES CCCNC1OC(=NC1C#N)c1cccc2ccccc12
Show InChI InChI=1S/C17H17N3O/c1-2-10-19-17-15(11-18)20-16(21-17)14-9-5-7-12-6-3-4-8-13(12)14/h3-9,15,17,19H,2,10H2,1H3
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n/an/a 100n/an/an/an/an/an/a



THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385579
PNG
(US10287279, Compound 21)
Show SMILES CCNC1OC(=NC1C#N)c1cccc2ccccc12
Show InChI InChI=1S/C16H15N3O/c1-2-18-16-14(10-17)19-15(20-16)13-9-5-7-11-6-3-4-8-12(11)13/h3-9,14,16,18H,2H2,1H3
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n/an/a 120n/an/an/an/an/an/a



THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385581
PNG
(US10287279, Compound 23)
Show SMILES CCCCNC1OC(=NC1C#N)c1cccc2ccccc12
Show InChI InChI=1S/C18H19N3O/c1-2-3-11-20-18-16(12-19)21-17(22-18)15-10-6-8-13-7-4-5-9-14(13)15/h4-10,16,18,20H,2-3,11H2,1H3
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n/an/a 120n/an/an/an/an/an/a



THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385559
PNG
(US10287279, Compound 1 | US10287279, Compound 20)
Show SMILES CNC1OC(=NC1C#N)c1cccc2ccccc12
Show InChI InChI=1S/C15H13N3O/c1-17-15-13(9-16)18-14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,13,15,17H,1H3
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n/an/a 200n/an/an/an/an/an/a



THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385559
PNG
(US10287279, Compound 1 | US10287279, Compound 20)
Show SMILES CNC1OC(=NC1C#N)c1cccc2ccccc12
Show InChI InChI=1S/C15H13N3O/c1-17-15-13(9-16)18-14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,13,15,17H,1H3
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n/an/a 200n/an/an/an/an/an/a



THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385559
PNG
(US10287279, Compound 1 | US10287279, Compound 20)
Show SMILES CNC1OC(=NC1C#N)c1cccc2ccccc12
Show InChI InChI=1S/C15H13N3O/c1-17-15-13(9-16)18-14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,13,15,17H,1H3
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n/an/a 200n/an/an/an/an/an/a



THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385582
PNG
(US10287279, Compound 24)
Show SMILES CCCCCNC1OC(=NC1C#N)c1cccc2ccccc12
Show InChI InChI=1S/C19H21N3O/c1-2-3-6-12-21-19-17(13-20)22-18(23-19)16-11-7-9-14-8-4-5-10-15(14)16/h4-5,7-11,17,19,21H,2-3,6,12H2,1H3
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n/an/a 300n/an/an/an/an/an/a



THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385565
PNG
(US10287279, Compound 7)
Show SMILES CNC1OC(=NC1C#N)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C11H9Cl2N3O/c1-15-11-8(5-14)16-10(17-11)6-3-2-4-7(12)9(6)13/h2-4,8,11,15H,1H3
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n/an/a 460n/an/an/an/an/an/a



THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385590
PNG
(US10287279, Compound 32)
Show SMILES CNC1SC(=NC1C#N)c1cccc2ccccc12
Show InChI InChI=1S/C15H13N3S/c1-17-15-13(9-16)18-14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,13,15,17H,1H3
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n/an/a 550n/an/an/an/an/an/a



THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385563
PNG
(US10287279, Compound 5)
Show SMILES CNC1OC(=NC1C#N)c1ccc2cnccc2c1
Show InChI InChI=1S/C14H12N4O/c1-16-14-12(7-15)18-13(19-14)10-2-3-11-8-17-5-4-9(11)6-10/h2-6,8,12,14,16H,1H3
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n/an/a 730n/an/an/an/an/an/a



THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385566
PNG
(US10287279, Compound 8)
Show SMILES CNC1OC(=NC1C#N)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C11H9Cl2N3O/c1-15-11-9(5-14)16-10(17-11)6-2-3-7(12)8(13)4-6/h2-4,9,11,15H,1H3
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n/an/a 810n/an/an/an/an/an/a



THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385583
PNG
(US10287279, Compound 25)
Show SMILES C=CCNC1OC(=NC1C#N)c1cccc2ccccc12
Show InChI InChI=1S/C17H15N3O/c1-2-10-19-17-15(11-18)20-16(21-17)14-9-5-7-12-6-3-4-8-13(12)14/h2-9,15,17,19H,1,10H2
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n/an/a 3.00E+3n/an/an/an/an/an/a



THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385562
PNG
(US10287279, Compound 4)
Show SMILES CNC1OC(=NC1C#N)c1cccc2ncccc12
Show InChI InChI=1S/C14H12N4O/c1-16-14-12(8-15)18-13(19-14)10-4-2-6-11-9(10)5-3-7-17-11/h2-7,12,14,16H,1H3
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n/an/a 3.60E+3n/an/an/an/an/an/a



THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385572
PNG
(US10287279, Compound 14)
Show SMILES CNC1OC(=NC1C#N)c1c[nH]c2ccccc12
Show InChI InChI=1/C13H12N4O/c1-15-13-11(6-14)17-12(18-13)9-7-16-10-5-3-2-4-8(9)10/h2-5,7,11,13,15-16H,1H3
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n/an/a 3.90E+3n/an/an/an/an/an/a



THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385593
PNG
(US10287279, Compound 35)
Show SMILES CNC1NN=C(O1)c1cccc2ccccc12
Show InChI InChI=1S/C13H13N3O/c1-14-13-16-15-12(17-13)11-8-4-6-9-5-2-3-7-10(9)11/h2-8,13-14,16H,1H3
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n/an/a 5.40E+3n/an/an/an/an/an/a



THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385574
PNG
(US10287279, Compound 16)
Show SMILES CNC1OC(=NC1C#N)c1cccc(Cl)c1
Show InChI InChI=1S/C11H10ClN3O/c1-14-11-9(6-13)15-10(16-11)7-3-2-4-8(12)5-7/h2-5,9,11,14H,1H3
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n/an/a 6.30E+3n/an/an/an/an/an/a



THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385568
PNG
(US10287279, Compound 10)
Show SMILES CNC1OC(=NC1C#N)c1ccc2OCOc2c1
Show InChI InChI=1S/C12H11N3O3/c1-14-12-8(5-13)15-11(18-12)7-2-3-9-10(4-7)17-6-16-9/h2-4,8,12,14H,6H2,1H3
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n/an/a 7.60E+3n/an/an/an/an/an/a



THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385585
PNG
(US10287279, Compound 27)
Show SMILES CC(=O)NC1OC(=NC1C#N)c1cccc2ccccc12
Show InChI InChI=1S/C16H13N3O2/c1-10(20)18-16-14(9-17)19-15(21-16)13-8-4-6-11-5-2-3-7-12(11)13/h2-8,14,16H,1H3,(H,18,20)
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n/an/a 1.00E+4n/an/an/an/an/an/a



THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385575
PNG
(US10287279, Compound 17)
Show SMILES CNC1OC(=NC1C#N)c1ccc(F)cc1
Show InChI InChI=1S/C11H10FN3O/c1-14-11-9(6-13)15-10(16-11)7-2-4-8(12)5-3-7/h2-5,9,11,14H,1H3
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n/an/a 1.50E+4n/an/an/an/an/an/a



THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385570
PNG
(US10287279, Compound 12)
Show SMILES CNC1OC(=NC1C#N)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C17H15N3O/c1-19-17-15(11-18)20-16(21-17)14-10-6-5-9-13(14)12-7-3-2-4-8-12/h2-10,15,17,19H,1H3
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n/an/a 2.30E+4n/an/an/an/an/an/a



THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385588
PNG
(US10287279, Compound 30)
Show SMILES N#CC1N=C(OC1NC1COC1)c1cccc2ccccc12
Show InChI InChI=1S/C17H15N3O2/c18-8-15-17(19-12-9-21-10-12)22-16(20-15)14-7-3-5-11-4-1-2-6-13(11)14/h1-7,12,15,17,19H,9-10H2
PDB

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n/an/a>2.50E+4n/an/an/an/an/an/a



THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385577
PNG
(US10287279, Compound 19)
Show SMILES NC1OC(=NC1C#N)c1cccc2ccccc12
Show InChI InChI=1S/C14H11N3O/c15-8-12-13(16)18-14(17-12)11-7-3-5-9-4-1-2-6-10(9)11/h1-7,12-13H,16H2
PDB

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n/an/a 2.50E+4n/an/an/an/an/an/a



THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385573
PNG
(US10287279, Compound 15)
Show SMILES CNC1OC(=NC1C#N)c1ccc(Cl)cc1
Show InChI InChI=1S/C11H10ClN3O/c1-14-11-9(6-13)15-10(16-11)7-2-4-8(12)5-3-7/h2-5,9,11,14H,1H3
PDB

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n/an/a 2.50E+4n/an/an/an/an/an/a



THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385560
PNG
(US10287279, Compound 2)
Show SMILES CNC1OC(=NC1C#N)c1ccc2ccccc2c1
Show InChI InChI=1S/C15H13N3O/c1-17-15-13(9-16)18-14(19-15)12-7-6-10-4-2-3-5-11(10)8-12/h2-8,13,15,17H,1H3
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THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385559
PNG
(US10287279, Compound 1 | US10287279, Compound 20)
Show SMILES CNC1OC(=NC1C#N)c1cccc2ccccc12
Show InChI InChI=1S/C15H13N3O/c1-17-15-13(9-16)18-14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,13,15,17H,1H3
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THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385561
PNG
(US10287279, Compound 3)
Show SMILES CNC1OC(=NC1C#N)c1cccc2cnccc12
Show InChI InChI=1S/C14H12N4O/c1-16-14-12(7-15)18-13(19-14)11-4-2-3-9-8-17-6-5-10(9)11/h2-6,8,12,14,16H,1H3
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THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385587
PNG
(US10287279, Compound 29)
Show SMILES N#CC1N=C(OC1Nc1ccccc1)c1cccc2ccccc12
Show InChI InChI=1S/C20H15N3O/c21-13-18-20(22-15-9-2-1-3-10-15)24-19(23-18)17-12-6-8-14-7-4-5-11-16(14)17/h1-12,18,20,22H
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n/an/a>3.00E+4n/an/an/an/an/an/a



THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385586
PNG
(US10287279, Compound 28)
Show SMILES N#CC1N=C(OC1NCc1ccccc1)c1cccc2ccccc12
Show InChI InChI=1S/C21H17N3O/c22-13-19-21(23-14-15-7-2-1-3-8-15)25-20(24-19)18-12-6-10-16-9-4-5-11-17(16)18/h1-12,19,21,23H,14H2
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THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385596
PNG
(US10287279, Compound 38)
Show SMILES CNC1SC(=NC1C(=O)OC)c1cccc2ccccc12
Show InChI InChI=1S/C16H16N2O2S/c1-17-15-13(16(19)20-2)18-14(21-15)12-9-5-7-10-6-3-4-8-11(10)12/h3-9,13,15,17H,1-2H3
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THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385569
PNG
(US10287279, Compound 11)
Show SMILES CNC1OC(=NC1C#N)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C17H15N3O/c1-19-17-15(11-18)20-16(21-17)14-9-7-13(8-10-14)12-5-3-2-4-6-12/h2-10,15,17,19H,1H3
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n/an/a>4.00E+4n/an/an/an/an/an/a



THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385591
PNG
(US10287279, Compound 33)
Show SMILES CNC1NC=C(O1)c1cccc2ccccc12
Show InChI InChI=1S/C14H14N2O/c1-15-14-16-9-13(17-14)12-8-4-6-10-5-2-3-7-11(10)12/h2-9,14-16H,1H3
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THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385595
PNG
(US10287279, Compound 37)
Show SMILES CNC1OC(=NC1C(=O)OC)c1cccc2ccccc12
Show InChI InChI=1S/C16H16N2O3/c1-17-15-13(16(19)20-2)18-14(21-15)12-9-5-7-10-6-3-4-8-11(10)12/h3-9,13,15,17H,1-2H3
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THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385592
PNG
(US10287279, Compound 34)
Show SMILES CNC1NC(C#N)=C(O1)c1cccc2ccccc12
Show InChI InChI=1S/C15H13N3O/c1-17-15-18-13(9-16)14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,15,17-18H,1H3
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THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385589
PNG
(US10287279, Compound 31)
Show SMILES N#CC1N=C(OC1NC1CNC1)c1cccc2ccccc12
Show InChI InChI=1S/C17H16N4O/c18-8-15-17(20-12-9-19-10-12)22-16(21-15)14-7-3-5-11-4-1-2-6-13(11)14/h1-7,12,15,17,19-20H,9-10H2
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THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385584
PNG
(US10287279, Compound 26)
Show SMILES CC(C)NC1OC(=NC1C#N)c1cccc2ccccc12
Show InChI InChI=1S/C17H17N3O/c1-11(2)19-17-15(10-18)20-16(21-17)14-9-5-7-12-6-3-4-8-13(12)14/h3-9,11,15,17,19H,1-2H3
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THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385571
PNG
(US10287279, Compound 13)
Show SMILES CNC1OC(=NC1C#N)c1ccc2cc[nH]c2c1
Show InChI InChI=1/C13H12N4O/c1-15-13-11(7-14)17-12(18-13)9-3-2-8-4-5-16-10(8)6-9/h2-6,11,13,15-16H,1H3
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THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385594
PNG
(US10287279, Compound 36)
Show SMILES CNC1NN=C(S1)c1cccc2ccccc12
Show InChI InChI=1S/C13H13N3S/c1-14-13-16-15-12(17-13)11-8-4-6-9-5-2-3-7-10(9)11/h2-8,13-14,16H,1H3
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THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50011790
PNG
(CHEMBL3262932 | US10287279, Compound 40)
Show SMILES CNc1nccc(n1)-c1cccc2ccccc12
Show InChI InChI=1S/C15H13N3/c1-16-15-17-10-9-14(18-15)13-8-4-6-11-5-2-3-7-12(11)13/h2-10H,1H3,(H,16,17,18)
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n/an/a>4.00E+4n/an/an/an/an/an/a



THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385564
PNG
(US10287279, Compound 6)
Show SMILES CNC1OC(=NC1C#N)c1cccc2nccnc12
Show InChI InChI=1S/C13H11N5O/c1-15-13-10(7-14)18-12(19-13)8-3-2-4-9-11(8)17-6-5-16-9/h2-6,10,13,15H,1H3
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THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385567
PNG
(US10287279, Compound 9)
Show SMILES CNC1OC(=NC1C#N)c1ccc2OCCOc2c1
Show InChI InChI=1S/C13H13N3O3/c1-15-13-9(7-14)16-12(19-13)8-2-3-10-11(6-8)18-5-4-17-10/h2-3,6,9,13,15H,4-5H2,1H3
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n/an/a>4.00E+4n/an/an/an/an/an/a



THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50011789
PNG
(CHEMBL3262931 | US10287279, Compound 39)
Show SMILES CNc1nc(ccc1C#N)-c1cccc2ccccc12
Show InChI InChI=1S/C17H13N3/c1-19-17-13(11-18)9-10-16(20-17)15-8-4-6-12-5-2-3-7-14(12)15/h2-10H,1H3,(H,19,20)
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n/an/a>4.00E+4n/an/an/an/an/an/a



THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385576
PNG
(US10287279, Compound 18)
Show SMILES CNC1OC(=NC1C#N)C1CCCC1
Show InChI InChI=1S/C10H15N3O/c1-12-10-8(6-11)13-9(14-10)7-4-2-3-5-7/h7-8,10,12H,2-5H2,1H3
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THE CHILDREN''S HOSPITAL CORPORATION; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%