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Patent code US10287279

Compile Data Set for Download or QSAR
Found 42 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385580
PNG
(US10287279, Compound 22)
Show SMILES CCCNC1OC(=NC1C#N)c1cccc2ccccc12
Show InChI InChI=1S/C17H17N3O/c1-2-10-19-17-15(11-18)20-16(21-17)14-9-5-7-12-6-3-4-8-13(12)14/h3-9,15,17,19H,2,10H2,1H3
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n/an/a 100n/an/an/an/an/an/a



THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385579
PNG
(US10287279, Compound 21)
Show SMILES CCNC1OC(=NC1C#N)c1cccc2ccccc12
Show InChI InChI=1S/C16H15N3O/c1-2-18-16-14(10-17)19-15(20-16)13-9-5-7-11-6-3-4-8-12(11)13/h3-9,14,16,18H,2H2,1H3
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n/an/a 120n/an/an/an/an/an/a



THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385581
PNG
(US10287279, Compound 23)
Show SMILES CCCCNC1OC(=NC1C#N)c1cccc2ccccc12
Show InChI InChI=1S/C18H19N3O/c1-2-3-11-20-18-16(12-19)21-17(22-18)15-10-6-8-13-7-4-5-9-14(13)15/h4-10,16,18,20H,2-3,11H2,1H3
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n/an/a 120n/an/an/an/an/an/a



THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385559
PNG
(US10287279, Compound 1 | US10287279, Compound 20)
Show SMILES CNC1OC(=NC1C#N)c1cccc2ccccc12
Show InChI InChI=1S/C15H13N3O/c1-17-15-13(9-16)18-14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,13,15,17H,1H3
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n/an/a 200n/an/an/an/an/an/a



THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385559
PNG
(US10287279, Compound 1 | US10287279, Compound 20)
Show SMILES CNC1OC(=NC1C#N)c1cccc2ccccc12
Show InChI InChI=1S/C15H13N3O/c1-17-15-13(9-16)18-14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,13,15,17H,1H3
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n/an/a 200n/an/an/an/an/an/a



THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385559
PNG
(US10287279, Compound 1 | US10287279, Compound 20)
Show SMILES CNC1OC(=NC1C#N)c1cccc2ccccc12
Show InChI InChI=1S/C15H13N3O/c1-17-15-13(9-16)18-14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,13,15,17H,1H3
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n/an/a 200n/an/an/an/an/an/a



THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385582
PNG
(US10287279, Compound 24)
Show SMILES CCCCCNC1OC(=NC1C#N)c1cccc2ccccc12
Show InChI InChI=1S/C19H21N3O/c1-2-3-6-12-21-19-17(13-20)22-18(23-19)16-11-7-9-14-8-4-5-10-15(14)16/h4-5,7-11,17,19,21H,2-3,6,12H2,1H3
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n/an/a 300n/an/an/an/an/an/a



THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385565
PNG
(US10287279, Compound 7)
Show SMILES CNC1OC(=NC1C#N)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C11H9Cl2N3O/c1-15-11-8(5-14)16-10(17-11)6-3-2-4-7(12)9(6)13/h2-4,8,11,15H,1H3
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n/an/a 460n/an/an/an/an/an/a



THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385590
PNG
(US10287279, Compound 32)
Show SMILES CNC1SC(=NC1C#N)c1cccc2ccccc12
Show InChI InChI=1S/C15H13N3S/c1-17-15-13(9-16)18-14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,13,15,17H,1H3
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n/an/a 550n/an/an/an/an/an/a



THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385563
PNG
(US10287279, Compound 5)
Show SMILES CNC1OC(=NC1C#N)c1ccc2cnccc2c1
Show InChI InChI=1S/C14H12N4O/c1-16-14-12(7-15)18-13(19-14)10-2-3-11-8-17-5-4-9(11)6-10/h2-6,8,12,14,16H,1H3
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n/an/a 730n/an/an/an/an/an/a



THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385566
PNG
(US10287279, Compound 8)
Show SMILES CNC1OC(=NC1C#N)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C11H9Cl2N3O/c1-15-11-9(5-14)16-10(17-11)6-2-3-7(12)8(13)4-6/h2-4,9,11,15H,1H3
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n/an/a 810n/an/an/an/an/an/a



THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385583
PNG
(US10287279, Compound 25)
Show SMILES C=CCNC1OC(=NC1C#N)c1cccc2ccccc12
Show InChI InChI=1S/C17H15N3O/c1-2-10-19-17-15(11-18)20-16(21-17)14-9-5-7-12-6-3-4-8-13(12)14/h2-9,15,17,19H,1,10H2
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n/an/a 3.00E+3n/an/an/an/an/an/a



THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385562
PNG
(US10287279, Compound 4)
Show SMILES CNC1OC(=NC1C#N)c1cccc2ncccc12
Show InChI InChI=1S/C14H12N4O/c1-16-14-12(8-15)18-13(19-14)10-4-2-6-11-9(10)5-3-7-17-11/h2-7,12,14,16H,1H3
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n/an/a 3.60E+3n/an/an/an/an/an/a



THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385572
PNG
(US10287279, Compound 14)
Show SMILES CNC1OC(=NC1C#N)c1c[nH]c2ccccc12
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n/an/a 3.90E+3n/an/an/an/an/an/a



THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385593
PNG
(US10287279, Compound 35)
Show SMILES CNC1NN=C(O1)c1cccc2ccccc12
Show InChI InChI=1S/C13H13N3O/c1-14-13-16-15-12(17-13)11-8-4-6-9-5-2-3-7-10(9)11/h2-8,13-14,16H,1H3
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n/an/a 5.40E+3n/an/an/an/an/an/a



THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385574
PNG
(US10287279, Compound 16)
Show SMILES CNC1OC(=NC1C#N)c1cccc(Cl)c1
Show InChI InChI=1S/C11H10ClN3O/c1-14-11-9(6-13)15-10(16-11)7-3-2-4-8(12)5-7/h2-5,9,11,14H,1H3
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n/an/a 6.30E+3n/an/an/an/an/an/a



THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385568
PNG
(US10287279, Compound 10)
Show SMILES CNC1OC(=NC1C#N)c1ccc2OCOc2c1
Show InChI InChI=1S/C12H11N3O3/c1-14-12-8(5-13)15-11(18-12)7-2-3-9-10(4-7)17-6-16-9/h2-4,8,12,14H,6H2,1H3
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n/an/a 7.60E+3n/an/an/an/an/an/a



THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385585
PNG
(US10287279, Compound 27)
Show SMILES CC(=O)NC1OC(=NC1C#N)c1cccc2ccccc12
Show InChI InChI=1S/C16H13N3O2/c1-10(20)18-16-14(9-17)19-15(21-16)13-8-4-6-11-5-2-3-7-12(11)13/h2-8,14,16H,1H3,(H,18,20)
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n/an/a 1.00E+4n/an/an/an/an/an/a



THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385575
PNG
(US10287279, Compound 17)
Show SMILES CNC1OC(=NC1C#N)c1ccc(F)cc1
Show InChI InChI=1S/C11H10FN3O/c1-14-11-9(6-13)15-10(16-11)7-2-4-8(12)5-3-7/h2-5,9,11,14H,1H3
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THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385570
PNG
(US10287279, Compound 12)
Show SMILES CNC1OC(=NC1C#N)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C17H15N3O/c1-19-17-15(11-18)20-16(21-17)14-10-6-5-9-13(14)12-7-3-2-4-8-12/h2-10,15,17,19H,1H3
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THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385588
PNG
(US10287279, Compound 30)
Show SMILES N#CC1N=C(OC1NC1COC1)c1cccc2ccccc12
Show InChI InChI=1S/C17H15N3O2/c18-8-15-17(19-12-9-21-10-12)22-16(20-15)14-7-3-5-11-4-1-2-6-13(11)14/h1-7,12,15,17,19H,9-10H2
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n/an/a>2.50E+4n/an/an/an/an/an/a



THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385577
PNG
(US10287279, Compound 19)
Show SMILES NC1OC(=NC1C#N)c1cccc2ccccc12
Show InChI InChI=1S/C14H11N3O/c15-8-12-13(16)18-14(17-12)11-7-3-5-9-4-1-2-6-10(9)11/h1-7,12-13H,16H2
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THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385573
PNG
(US10287279, Compound 15)
Show SMILES CNC1OC(=NC1C#N)c1ccc(Cl)cc1
Show InChI InChI=1S/C11H10ClN3O/c1-14-11-9(6-13)15-10(16-11)7-2-4-8(12)5-3-7/h2-5,9,11,14H,1H3
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THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385560
PNG
(US10287279, Compound 2)
Show SMILES CNC1OC(=NC1C#N)c1ccc2ccccc2c1
Show InChI InChI=1S/C15H13N3O/c1-17-15-13(9-16)18-14(19-15)12-7-6-10-4-2-3-5-11(10)8-12/h2-8,13,15,17H,1H3
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THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385559
PNG
(US10287279, Compound 1 | US10287279, Compound 20)
Show SMILES CNC1OC(=NC1C#N)c1cccc2ccccc12
Show InChI InChI=1S/C15H13N3O/c1-17-15-13(9-16)18-14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,13,15,17H,1H3
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THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385561
PNG
(US10287279, Compound 3)
Show SMILES CNC1OC(=NC1C#N)c1cccc2cnccc12
Show InChI InChI=1S/C14H12N4O/c1-16-14-12(7-15)18-13(19-14)11-4-2-3-9-8-17-6-5-10(9)11/h2-6,8,12,14,16H,1H3
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THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385587
PNG
(US10287279, Compound 29)
Show SMILES N#CC1N=C(OC1Nc1ccccc1)c1cccc2ccccc12
Show InChI InChI=1S/C20H15N3O/c21-13-18-20(22-15-9-2-1-3-10-15)24-19(23-18)17-12-6-8-14-7-4-5-11-16(14)17/h1-12,18,20,22H
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THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385586
PNG
(US10287279, Compound 28)
Show SMILES N#CC1N=C(OC1NCc1ccccc1)c1cccc2ccccc12
Show InChI InChI=1S/C21H17N3O/c22-13-19-21(23-14-15-7-2-1-3-8-15)25-20(24-19)18-12-6-10-16-9-4-5-11-17(16)18/h1-12,19,21,23H,14H2
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THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385596
PNG
(US10287279, Compound 38)
Show SMILES CNC1SC(=NC1C(=O)OC)c1cccc2ccccc12
Show InChI InChI=1S/C16H16N2O2S/c1-17-15-13(16(19)20-2)18-14(21-15)12-9-5-7-10-6-3-4-8-11(10)12/h3-9,13,15,17H,1-2H3
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THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385569
PNG
(US10287279, Compound 11)
Show SMILES CNC1OC(=NC1C#N)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C17H15N3O/c1-19-17-15(11-18)20-16(21-17)14-9-7-13(8-10-14)12-5-3-2-4-6-12/h2-10,15,17,19H,1H3
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THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385591
PNG
(US10287279, Compound 33)
Show SMILES CNC1NC=C(O1)c1cccc2ccccc12
Show InChI InChI=1S/C14H14N2O/c1-15-14-16-9-13(17-14)12-8-4-6-10-5-2-3-7-11(10)12/h2-9,14-16H,1H3
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THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385595
PNG
(US10287279, Compound 37)
Show SMILES CNC1OC(=NC1C(=O)OC)c1cccc2ccccc12
Show InChI InChI=1S/C16H16N2O3/c1-17-15-13(16(19)20-2)18-14(21-15)12-9-5-7-10-6-3-4-8-11(10)12/h3-9,13,15,17H,1-2H3
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THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385592
PNG
(US10287279, Compound 34)
Show SMILES CNC1NC(C#N)=C(O1)c1cccc2ccccc12
Show InChI InChI=1S/C15H13N3O/c1-17-15-18-13(9-16)14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,15,17-18H,1H3
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THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385589
PNG
(US10287279, Compound 31)
Show SMILES N#CC1N=C(OC1NC1CNC1)c1cccc2ccccc12
Show InChI InChI=1S/C17H16N4O/c18-8-15-17(20-12-9-19-10-12)22-16(21-15)14-7-3-5-11-4-1-2-6-13(11)14/h1-7,12,15,17,19-20H,9-10H2
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THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385584
PNG
(US10287279, Compound 26)
Show SMILES CC(C)NC1OC(=NC1C#N)c1cccc2ccccc12
Show InChI InChI=1S/C17H17N3O/c1-11(2)19-17-15(10-18)20-16(21-17)14-9-5-7-12-6-3-4-8-13(12)14/h3-9,11,15,17,19H,1-2H3
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THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385571
PNG
(US10287279, Compound 13)
Show SMILES CNC1OC(=NC1C#N)c1ccc2cc[nH]c2c1
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THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385594
PNG
(US10287279, Compound 36)
Show SMILES CNC1NN=C(S1)c1cccc2ccccc12
Show InChI InChI=1S/C13H13N3S/c1-14-13-16-15-12(17-13)11-8-4-6-9-5-2-3-7-10(9)11/h2-8,13-14,16H,1H3
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THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50011790
PNG
(CHEMBL3262932 | US10287279, Compound 40)
Show SMILES CNc1nccc(n1)-c1cccc2ccccc12
Show InChI InChI=1S/C15H13N3/c1-16-15-17-10-9-14(18-15)13-8-4-6-11-5-2-3-7-12(11)13/h2-10H,1H3,(H,16,17,18)
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US Patent
n/an/a>4.00E+4n/an/an/an/an/an/a



THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385564
PNG
(US10287279, Compound 6)
Show SMILES CNC1OC(=NC1C#N)c1cccc2nccnc12
Show InChI InChI=1S/C13H11N5O/c1-15-13-10(7-14)18-12(19-13)8-3-2-4-9-11(8)17-6-5-16-9/h2-6,10,13,15H,1H3
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THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385567
PNG
(US10287279, Compound 9)
Show SMILES CNC1OC(=NC1C#N)c1ccc2OCCOc2c1
Show InChI InChI=1S/C13H13N3O3/c1-15-13-9(7-14)16-12(19-13)8-2-3-10-11(6-8)18-5-4-17-10/h2-3,6,9,13,15H,4-5H2,1H3
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THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50011789
PNG
(CHEMBL3262931 | US10287279, Compound 39)
Show SMILES CNc1nc(ccc1C#N)-c1cccc2ccccc12
Show InChI InChI=1S/C17H13N3/c1-19-17-13(11-18)9-10-16(20-17)15-8-4-6-12-5-2-3-7-14(12)15/h2-10H,1H3,(H,19,20)
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THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM385576
PNG
(US10287279, Compound 18)
Show SMILES CNC1OC(=NC1C#N)C1CCCC1
Show InChI InChI=1S/C10H15N3O/c1-12-10-8(6-11)13-9(14-10)7-4-2-3-5-7/h7-8,10,12H,2-5H2,1H3
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THE CHILDREN'S HOSPITAL CORPORATION

US Patent


Assay Description
The inhibitor compounds were screened initially using one concentration point on a Perkin-Elmer Lambda 40 UV-Vis spectrometer. The percent inhibition...


US Patent US10287279 (2019)


BindingDB Entry DOI: 10.7270/Q2V98BD1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%