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Patent code US10287292

Compile Data Set for Download or QSAR
Found 184 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385611
PNG
(US10287292, Compound 1.013)
Show SMILES CCc1cn2cccc2c(n1)N1CC[C@@H](C1)NC(=O)c1ncn(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H22FN7O/c1-2-16-12-28-10-3-4-19(28)21(25-16)29-11-9-17(13-29)26-22(31)20-24-14-30(27-20)18-7-5-15(23)6-8-18/h3-8,10,12,14,17H,2,9,11,13H2,1H3,(H,26,31)/t17-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385626
PNG
(US10287292, Compound 1.021)
Show SMILES Cc1cn2cccc2c(n1)N1CC[C@@H](C1)NC(=O)c1noc(n1)-c1ccccc1
Show InChI InChI=1S/C21H20N6O2/c1-14-12-26-10-5-8-17(26)19(22-14)27-11-9-16(13-27)23-20(28)18-24-21(29-25-18)15-6-3-2-4-7-15/h2-8,10,12,16H,9,11,13H2,1H3,(H,23,28)/t16-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385629
PNG
(US10287292, Compound 1.023)
Show SMILES Cc1cn2cccc2c(n1)N1CC[C@@H](C1)NC(=O)c1csc(n1)-c1ccccc1
Show InChI InChI=1S/C22H21N5OS/c1-15-12-26-10-5-8-19(26)20(23-15)27-11-9-17(13-27)24-21(28)18-14-29-22(25-18)16-6-3-2-4-7-16/h2-8,10,12,14,17H,9,11,13H2,1H3,(H,24,28)/t17-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385717
PNG
(US10287292, Compound 1.029)
Show SMILES Cc1cn2cccc2c(n1)N1CC[C@@H](C1)NC(=O)c1ccn(n1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H21ClN6O/c1-15-13-27-10-2-3-20(27)21(24-15)28-11-8-17(14-28)25-22(30)19-9-12-29(26-19)18-6-4-16(23)5-7-18/h2-7,9-10,12-13,17H,8,11,14H2,1H3,(H,25,30)/t17-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385819
PNG
(US10287292, Compound 1.035)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cnnc12)c1cn(cn1)-c1ccccc1
Show InChI InChI=1S/C19H18N8O/c28-19(16-11-27(12-21-16)15-4-2-1-3-5-15)23-14-6-8-25(10-14)17-18-24-22-13-26(18)9-7-20-17/h1-5,7,9,11-14H,6,8,10H2,(H,23,28)/t14-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385880
PNG
(US10287292, Compound 1.058)
Show SMILES OCC1(CCN(C1)c1nccn2ccnc12)NC(=O)c1csc(n1)N1CCC(O)CC1
Show InChI InChI=1S/C20H25N7O3S/c28-13-20(3-8-27(12-20)17-16-21-4-9-25(16)10-5-22-17)24-18(30)15-11-31-19(23-15)26-6-1-14(29)2-7-26/h4-5,9-11,14,28-29H,1-3,6-8,12-13H2,(H,24,30)
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385884
PNG
(US10287292, Compound 1.062)
Show SMILES O[C@H]1CN(CC1NC(=O)c1ccn(n1)-c1ccc(F)cc1)c1nccn2cccc12
Show InChI InChI=1S/C21H19FN6O2/c22-14-3-5-15(6-4-14)28-10-7-16(25-28)21(30)24-17-12-27(13-19(17)29)20-18-2-1-9-26(18)11-8-23-20/h1-11,17,19,29H,12-13H2,(H,24,30)/t17?,19-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385892
PNG
(US10287292, Compound 1.070)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2ccnc12)c1coc(n1)-c1ccccc1
Show InChI InChI=1S/C20H18N6O2/c27-19(16-13-28-20(24-16)14-4-2-1-3-5-14)23-15-6-9-26(12-15)18-17-21-7-10-25(17)11-8-22-18/h1-5,7-8,10-11,13,15H,6,9,12H2,(H,23,27)/t15-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385898
PNG
(US10287292, Compound 1.076)
Show SMILES Fc1ccc(cc1)-c1cnc(nc1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C22H19FN6O/c23-17-5-3-15(4-6-17)16-12-25-20(26-13-16)22(30)27-18-7-10-29(14-18)21-19-2-1-9-28(19)11-8-24-21/h1-6,8-9,11-13,18H,7,10,14H2,(H,27,30)/t18-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385914
PNG
(US10287292, Compound 1.092)
Show SMILES Fc1ccc(cc1)-n1ccc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2ccnc12
Show InChI InChI=1S/C20H18FN7O/c21-14-1-3-16(4-2-14)28-10-6-17(25-28)20(29)24-15-5-9-27(13-15)19-18-22-7-11-26(18)12-8-23-19/h1-4,6-8,10-12,15H,5,9,13H2,(H,24,29)/t15-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385915
PNG
(US10287292, Compound 1.093)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cccc12)c1ncc(cn1)-c1ccccc1
Show InChI InChI=1S/C22H20N6O/c29-22(20-24-13-17(14-25-20)16-5-2-1-3-6-16)26-18-8-11-28(15-18)21-19-7-4-10-27(19)12-9-23-21/h1-7,9-10,12-14,18H,8,11,15H2,(H,26,29)/t18-/m0/s1
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UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385921
PNG
(US10287292, Compound 1.099)
Show SMILES Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3ccn(n3)-c3cccc(F)c3)c12
Show InChI InChI=1S/C22H21FN6O/c1-15-5-9-27-12-8-24-21(20(15)27)28-10-6-17(14-28)25-22(30)19-7-11-29(26-19)18-4-2-3-16(23)13-18/h2-5,7-9,11-13,17H,6,10,14H2,1H3,(H,25,30)/t17-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385928
PNG
(US10287292, Compound 1.106)
Show SMILES Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3ccn(n3)-c3ccc(F)cc3)c12
Show InChI InChI=1S/C22H21FN6O/c1-15-6-10-27-13-9-24-21(20(15)27)28-11-7-17(14-28)25-22(30)19-8-12-29(26-19)18-4-2-16(23)3-5-18/h2-6,8-10,12-13,17H,7,11,14H2,1H3,(H,25,30)/t17-/m0/s1
UniProtKB/SwissProt

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UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385929
PNG
(US10287292, Compound 1.107)
Show SMILES Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3coc(n3)-c3ccccc3)c12
Show InChI InChI=1S/C22H21N5O2/c1-15-7-10-26-12-9-23-20(19(15)26)27-11-8-17(13-27)24-21(28)18-14-29-22(25-18)16-5-3-2-4-6-16/h2-7,9-10,12,14,17H,8,11,13H2,1H3,(H,24,28)/t17-/m0/s1
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UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385932
PNG
(US10287292, Compound 1.110)
Show SMILES Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3ncc(cn3)-c3ccccc3)c12
Show InChI InChI=1S/C23H22N6O/c1-16-7-10-28-12-9-24-22(20(16)28)29-11-8-19(15-29)27-23(30)21-25-13-18(14-26-21)17-5-3-2-4-6-17/h2-7,9-10,12-14,19H,8,11,15H2,1H3,(H,27,30)/t19-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385936
PNG
(US10287292, Compound 1.114)
Show SMILES Fc1cc(ccc1Cl)-n1ccc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C21H18ClFN6O/c22-16-4-3-15(12-17(16)23)29-10-6-18(26-29)21(30)25-14-5-9-28(13-14)20-19-2-1-8-27(19)11-7-24-20/h1-4,6-8,10-12,14H,5,9,13H2,(H,25,30)/t14-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385939
PNG
(US10287292, Compound 1.117)
Show SMILES Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3ncn(n3)-c3ccccc3)c12
Show InChI InChI=1S/C21H21N7O/c1-15-7-10-26-12-9-22-20(18(15)26)27-11-8-16(13-27)24-21(29)19-23-14-28(25-19)17-5-3-2-4-6-17/h2-7,9-10,12,14,16H,8,11,13H2,1H3,(H,24,29)/t16-/m0/s1
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UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385945
PNG
(US10287292, Compound 1.123)
Show SMILES Cc1ccccc1-n1ccc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C22H22N6O/c1-16-5-2-3-6-19(16)28-13-9-18(25-28)22(29)24-17-8-12-27(15-17)21-20-7-4-11-26(20)14-10-23-21/h2-7,9-11,13-14,17H,8,12,15H2,1H3,(H,24,29)/t17-/m0/s1
UniProtKB/SwissProt

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UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385951
PNG
(US10287292, Compound 1.129)
Show SMILES Clc1ccc(cc1)-n1ccc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C21H19ClN6O/c22-15-3-5-17(6-4-15)28-12-8-18(25-28)21(29)24-16-7-11-27(14-16)20-19-2-1-10-26(19)13-9-23-20/h1-6,8-10,12-13,16H,7,11,14H2,(H,24,29)/t16-/m0/s1
UniProtKB/SwissProt

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UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385597
PNG
(US10287292, Compound 1.001)
Show SMILES Cc1nc(nn1-c1ccc(F)cc1)C(=O)N[C@H]1CCN(C1)c1nccn2ccnc12
Show InChI InChI=1S/C20H19FN8O/c1-13-24-17(26-29(13)16-4-2-14(21)3-5-16)20(30)25-15-6-9-28(12-15)19-18-22-7-10-27(18)11-8-23-19/h2-5,7-8,10-11,15H,6,9,12H2,1H3,(H,25,30)/t15-/m0/s1
UniProtKB/SwissProt

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UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385743
PNG
(US10287292, Compound 1.031)
Show SMILES Cc1cn2ccnc2c(n1)N1CC[C@@H](C1)NC(=O)c1cn(cn1)-c1ccccc1
Show InChI InChI=1S/C21H21N7O/c1-15-11-27-10-8-22-19(27)20(24-15)26-9-7-16(12-26)25-21(29)18-13-28(14-23-18)17-5-3-2-4-6-17/h2-6,8,10-11,13-14,16H,7,9,12H2,1H3,(H,25,29)/t16-/m0/s1
UniProtKB/SwissProt

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UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385805
PNG
(US10287292, Compound 1.032)
Show SMILES Cc1cn2ccnc2c(n1)N1CC[C@@H](C1)NC(=O)c1ncn(n1)-c1ccccc1
Show InChI InChI=1S/C20H20N8O/c1-14-11-27-10-8-21-18(27)19(23-14)26-9-7-15(12-26)24-20(29)17-22-13-28(25-17)16-5-3-2-4-6-16/h2-6,8,10-11,13,15H,7,9,12H2,1H3,(H,24,29)/t15-/m0/s1
UniProtKB/SwissProt

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UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385864
PNG
(US10287292, Compound 1.042)
Show SMILES NC(=O)C1(CCN(C1)c1nccn2cccc12)NC(=O)c1ccn(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H20FN7O2/c23-15-3-5-16(6-4-15)30-11-7-17(27-30)20(31)26-22(21(24)32)8-12-29(14-22)19-18-2-1-10-28(18)13-9-25-19/h1-7,9-11,13H,8,12,14H2,(H2,24,32)(H,26,31)
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385873
PNG
(US10287292, Compound 1.051)
Show SMILES OCC1(CCN(C1)c1nccn2cccc12)NC(=O)c1ncn(n1)-c1ccccc1
Show InChI InChI=1S/C21H21N7O2/c29-14-21(8-11-27(13-21)19-17-7-4-10-26(17)12-9-22-19)24-20(30)18-23-15-28(25-18)16-5-2-1-3-6-16/h1-7,9-10,12,15,29H,8,11,13-14H2,(H,24,30)
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385882
PNG
(US10287292, Compound 1.060)
Show SMILES CC(C)c1cnc(nc1)C(=O)NC1(CO)CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C20H24N6O2/c1-14(2)15-10-22-17(23-11-15)19(28)24-20(13-27)5-8-26(12-20)18-16-4-3-7-25(16)9-6-21-18/h3-4,6-7,9-11,14,27H,5,8,12-13H2,1-2H3,(H,24,28)
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385889
PNG
(US10287292, Compound 1.067)
Show SMILES Fc1ccc(cc1)-n1ccc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2ncnc12
Show InChI InChI=1S/C19H17FN8O/c20-13-1-3-15(4-2-13)27-9-6-16(25-27)19(29)24-14-5-8-26(11-14)17-18-22-12-23-28(18)10-7-21-17/h1-4,6-7,9-10,12,14H,5,8,11H2,(H,24,29)/t14-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385895
PNG
(US10287292, Compound 1.073)
Show SMILES OCC1(CCN(C1)c1nccn2cccc12)NC(=O)c1ccn(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H21FN6O2/c23-16-3-5-17(6-4-16)29-11-7-18(26-29)21(31)25-22(15-30)8-12-28(14-22)20-19-2-1-10-27(19)13-9-24-20/h1-7,9-11,13,30H,8,12,14-15H2,(H,25,31)
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385904
PNG
(US10287292, Compound 1.082)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cccc12)c1noc(n1)C1CCOCC1
Show InChI InChI=1S/C19H22N6O3/c26-18(16-22-19(28-23-16)13-4-10-27-11-5-13)21-14-3-8-25(12-14)17-15-2-1-7-24(15)9-6-20-17/h1-2,6-7,9,13-14H,3-5,8,10-12H2,(H,21,26)/t14-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385912
PNG
(US10287292, Compound 1.090)
Show SMILES Fc1ccc(cc1)-n1cnc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2ccnc12
Show InChI InChI=1S/C19H17FN8O/c20-13-1-3-15(4-2-13)28-12-23-16(25-28)19(29)24-14-5-8-27(11-14)18-17-21-6-9-26(17)10-7-22-18/h1-4,6-7,9-10,12,14H,5,8,11H2,(H,24,29)/t14-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385915
PNG
(US10287292, Compound 1.093)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cccc12)c1ncc(cn1)-c1ccccc1
Show InChI InChI=1S/C22H20N6O/c29-22(20-24-13-17(14-25-20)16-5-2-1-3-6-16)26-18-8-11-28(15-18)21-19-7-4-10-27(19)12-9-23-21/h1-7,9-10,12-14,18H,8,11,15H2,(H,26,29)/t18-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385918
PNG
(US10287292, Compound 1.096)
Show SMILES Fc1ccc(cc1)-c1nc(cs1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C21H18FN5OS/c22-15-5-3-14(4-6-15)21-25-17(13-29-21)20(28)24-16-7-10-27(12-16)19-18-2-1-9-26(18)11-8-23-19/h1-6,8-9,11,13,16H,7,10,12H2,(H,24,28)/t16-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385922
PNG
(US10287292, Compound 1.100)
Show SMILES Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3ccn(n3)-c3ccc(Cl)c(F)c3)c12
Show InChI InChI=1S/C22H20ClFN6O/c1-14-4-8-28-11-7-25-21(20(14)28)29-9-5-15(13-29)26-22(31)19-6-10-30(27-19)16-2-3-17(23)18(24)12-16/h2-4,6-8,10-12,15H,5,9,13H2,1H3,(H,26,31)/t15-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385927
PNG
(US10287292, Compound 1.105)
Show SMILES Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3csc(n3)-c3ccccc3)c12
Show InChI InChI=1S/C22H21N5OS/c1-15-7-10-26-12-9-23-20(19(15)26)27-11-8-17(13-27)24-21(28)18-14-29-22(25-18)16-5-3-2-4-6-16/h2-7,9-10,12,14,17H,8,11,13H2,1H3,(H,24,28)/t17-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385930
PNG
(US10287292, Compound 1.108)
Show SMILES Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3csc(n3)-c3ccc(F)cc3)c12
Show InChI InChI=1S/C22H20FN5OS/c1-14-6-9-27-11-8-24-20(19(14)27)28-10-7-17(12-28)25-21(29)18-13-30-22(26-18)15-2-4-16(23)5-3-15/h2-6,8-9,11,13,17H,7,10,12H2,1H3,(H,25,29)/t17-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385931
PNG
(US10287292, Compound 1.109)
Show SMILES Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3ccn(n3)-c3ccccc3C)c12
Show InChI InChI=1S/C23H24N6O/c1-16-5-3-4-6-20(16)29-13-9-19(26-29)23(30)25-18-8-12-28(15-18)22-21-17(2)7-11-27(21)14-10-24-22/h3-7,9-11,13-14,18H,8,12,15H2,1-2H3,(H,25,30)/t18-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385933
PNG
(US10287292, Compound 1.111)
Show SMILES Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3noc(n3)-c3ccccc3)c12
Show InChI InChI=1S/C21H20N6O2/c1-14-7-10-26-12-9-22-19(17(14)26)27-11-8-16(13-27)23-20(28)18-24-21(29-25-18)15-5-3-2-4-6-15/h2-7,9-10,12,16H,8,11,13H2,1H3,(H,23,28)/t16-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385935
PNG
(US10287292, Compound 1.113)
Show SMILES Fc1cccc(c1)-n1ccc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C21H19FN6O/c22-15-3-1-4-17(13-15)28-11-7-18(25-28)21(29)24-16-6-10-27(14-16)20-19-5-2-9-26(19)12-8-23-20/h1-5,7-9,11-13,16H,6,10,14H2,(H,24,29)/t16-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385937
PNG
(US10287292, Compound 1.115)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cccc12)c1ccn(n1)-c1ccccc1CC#N
Show InChI InChI=1S/C23H21N7O/c24-10-7-17-4-1-2-5-20(17)30-14-9-19(27-30)23(31)26-18-8-13-29(16-18)22-21-6-3-12-28(21)15-11-25-22/h1-6,9,11-12,14-15,18H,7-8,13,16H2,(H,26,31)/t18-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385938
PNG
(US10287292, Compound 1.116)
Show SMILES Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3coc(n3)-c3ccc(F)cc3)c12
Show InChI InChI=1S/C22H20FN5O2/c1-14-6-9-27-11-8-24-20(19(14)27)28-10-7-17(12-28)25-21(29)18-13-30-22(26-18)15-2-4-16(23)5-3-15/h2-6,8-9,11,13,17H,7,10,12H2,1H3,(H,25,29)/t17-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385946
PNG
(US10287292, Compound 1.124)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cccc12)c1csc(n1)-c1ccccc1
Show InChI InChI=1S/C21H19N5OS/c27-20(17-14-28-21(24-17)15-5-2-1-3-6-15)23-16-8-11-26(13-16)19-18-7-4-10-25(18)12-9-22-19/h1-7,9-10,12,14,16H,8,11,13H2,(H,23,27)/t16-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385950
PNG
(US10287292, Compound 1.128)
Show SMILES Cc1ccc(cc1)-n1ccc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C22H22N6O/c1-16-4-6-18(7-5-16)28-13-9-19(25-28)22(29)24-17-8-12-27(15-17)21-20-3-2-11-26(20)14-10-23-21/h2-7,9-11,13-14,17H,8,12,15H2,1H3,(H,24,29)/t17-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385950
PNG
(US10287292, Compound 1.128)
Show SMILES Cc1ccc(cc1)-n1ccc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C22H22N6O/c1-16-4-6-18(7-5-16)28-13-9-19(25-28)22(29)24-17-8-12-27(15-17)21-20-3-2-11-26(20)14-10-23-21/h2-7,9-11,13-14,17H,8,12,15H2,1H3,(H,24,29)/t17-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385619
PNG
(US10287292, Compound 1.017)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cccc12)c1cn(nn1)-c1ccccc1
Show InChI InChI=1S/C20H19N7O/c28-20(17-14-27(24-23-17)16-5-2-1-3-6-16)22-15-8-11-26(13-15)19-18-7-4-10-25(18)12-9-21-19/h1-7,9-10,12,14-15H,8,11,13H2,(H,22,28)/t15-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385625
PNG
(US10287292, Compound 1.020)
Show SMILES Cc1cn2cccc2c(n1)N1CC[C@@H](C1)NC(=O)c1ncn(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H20FN7O/c1-14-11-27-9-2-3-18(27)20(24-14)28-10-8-16(12-28)25-21(30)19-23-13-29(26-19)17-6-4-15(22)5-7-17/h2-7,9,11,13,16H,8,10,12H2,1H3,(H,25,30)/t16-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385859
PNG
(US10287292, Compound 1.037)
Show SMILES Cc1cn2cccc2c(n1)N1CC[C@@H](C1)NC(=O)c1csc(n1)N1CCC(O)CC1
Show InChI InChI=1S/C21H26N6O2S/c1-14-11-26-7-2-3-18(26)19(22-14)27-8-4-15(12-27)23-20(29)17-13-30-21(24-17)25-9-5-16(28)6-10-25/h2-3,7,11,13,15-16,28H,4-6,8-10,12H2,1H3,(H,23,29)/t15-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385867
PNG
(US10287292, Compound 1.045)
Show SMILES Cc1ccccc1-c1nc(cs1)C(=O)N[C@H]1CCN(C1)c1nccn2ccnc12
Show InChI InChI=1S/C21H20N6OS/c1-14-4-2-3-5-16(14)21-25-17(13-29-21)20(28)24-15-6-9-27(12-15)19-18-22-7-10-26(18)11-8-23-19/h2-5,7-8,10-11,13,15H,6,9,12H2,1H3,(H,24,28)/t15-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385872
PNG
(US10287292, Compound 1.050)
Show SMILES OCC1(CCN(C1)c1nccn2ccnc12)NC(=O)c1ncn(n1)-c1ccccc1
Show InChI InChI=1S/C20H20N8O2/c29-13-20(6-9-27(12-20)18-17-21-7-10-26(17)11-8-22-18)24-19(30)16-23-14-28(25-16)15-4-2-1-3-5-15/h1-5,7-8,10-11,14,29H,6,9,12-13H2,(H,24,30)
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385876
PNG
(US10287292, Compound 1.054)
Show SMILES Cc1ccccc1-n1ccc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2cnnc12
Show InChI InChI=1S/C20H20N8O/c1-14-4-2-3-5-17(14)28-10-7-16(25-28)20(29)23-15-6-9-26(12-15)18-19-24-22-13-27(19)11-8-21-18/h2-5,7-8,10-11,13,15H,6,9,12H2,1H3,(H,23,29)/t15-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385898
PNG
(US10287292, Compound 1.076)
Show SMILES Fc1ccc(cc1)-c1cnc(nc1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C22H19FN6O/c23-17-5-3-15(4-6-17)16-12-25-20(26-13-16)22(30)27-18-7-10-29(14-18)21-19-2-1-9-28(19)11-8-24-21/h1-6,8-9,11-13,18H,7,10,14H2,(H,27,30)/t18-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385901
PNG
(US10287292, Compound 1.079)
Show SMILES OC1CCN(CC1)c1nc(cs1)C(=O)N[C@H]1CCN(C1)c1nccn2ccnc12
Show InChI InChI=1S/C19H23N7O2S/c27-14-2-7-25(8-3-14)19-23-15(12-29-19)18(28)22-13-1-6-26(11-13)17-16-20-4-9-24(16)10-5-21-17/h4-5,9-10,12-14,27H,1-3,6-8,11H2,(H,22,28)/t13-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385903
PNG
(US10287292, Compound 1.081)
Show SMILES Clc1ccc(nc1)-n1ccc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C20H18ClN7O/c21-14-3-4-18(23-12-14)28-10-6-16(25-28)20(29)24-15-5-9-27(13-15)19-17-2-1-8-26(17)11-7-22-19/h1-4,6-8,10-12,15H,5,9,13H2,(H,24,29)/t15-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385910
PNG
(US10287292, Compound 1.088)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cccc12)c1ccn(n1)C1CCOCC1
Show InChI InChI=1S/C20H24N6O2/c27-20(17-4-10-26(23-17)16-5-12-28-13-6-16)22-15-3-9-25(14-15)19-18-2-1-8-24(18)11-7-21-19/h1-2,4,7-8,10-11,15-16H,3,5-6,9,12-14H2,(H,22,27)/t15-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385910
PNG
(US10287292, Compound 1.088)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cccc12)c1ccn(n1)C1CCOCC1
Show InChI InChI=1S/C20H24N6O2/c27-20(17-4-10-26(23-17)16-5-12-28-13-6-16)22-15-3-9-25(14-15)19-18-2-1-8-24(18)11-7-21-19/h1-2,4,7-8,10-11,15-16H,3,5-6,9,12-14H2,(H,22,27)/t15-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385917
PNG
(US10287292, Compound 1.095)
Show SMILES Fc1ccc(cc1)-c1nc(co1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C21H18FN5O2/c22-15-5-3-14(4-6-15)21-25-17(13-29-21)20(28)24-16-7-10-27(12-16)19-18-2-1-9-26(18)11-8-23-19/h1-6,8-9,11,13,16H,7,10,12H2,(H,24,28)/t16-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385939
PNG
(US10287292, Compound 1.117)
Show SMILES Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3ncn(n3)-c3ccccc3)c12
Show InChI InChI=1S/C21H21N7O/c1-15-7-10-26-12-9-22-20(18(15)26)27-11-8-16(13-27)24-21(29)19-23-14-28(25-19)17-5-3-2-4-6-17/h2-7,9-10,12,14,16H,8,11,13H2,1H3,(H,24,29)/t16-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385940
PNG
(US10287292, Compound 1.118)
Show SMILES Cc1ccccc1-n1cnc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C21H21N7O/c1-15-5-2-3-6-17(15)28-14-23-19(25-28)21(29)24-16-8-11-27(13-16)20-18-7-4-10-26(18)12-9-22-20/h2-7,9-10,12,14,16H,8,11,13H2,1H3,(H,24,29)/t16-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385944
PNG
(US10287292, Compound 1.122)
Show SMILES Fc1ccc(cc1)-c1nc(co1)C(=O)N[C@H]1CCN(C1)c1nccn2cnnc12
Show InChI InChI=1S/C19H16FN7O2/c20-13-3-1-12(2-4-13)19-24-15(10-29-19)18(28)23-14-5-7-26(9-14)16-17-25-22-11-27(17)8-6-21-16/h1-4,6,8,10-11,14H,5,7,9H2,(H,23,28)/t14-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385947
PNG
(US10287292, Compound 1.125)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cccc12)c1coc(n1)-c1ccccc1
Show InChI InChI=1S/C21H19N5O2/c27-20(17-14-28-21(24-17)15-5-2-1-3-6-15)23-16-8-11-26(13-16)19-18-7-4-10-25(18)12-9-22-19/h1-7,9-10,12,14,16H,8,11,13H2,(H,23,27)/t16-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385949
PNG
(US10287292, Compound 1.127)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cnnc12)c1ncn(n1)-c1ccccc1
Show InChI InChI=1S/C18H17N9O/c28-18(15-20-11-27(24-15)14-4-2-1-3-5-14)22-13-6-8-25(10-13)16-17-23-21-12-26(17)9-7-19-16/h1-5,7,9,11-13H,6,8,10H2,(H,22,28)/t13-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385599
PNG
(US10287292, Compound 1.003)
Show SMILES Fc1ccc(cc1)-n1cnc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C20H18FN7O/c21-14-3-5-16(6-4-14)28-13-23-18(25-28)20(29)24-15-7-10-27(12-15)19-17-2-1-9-26(17)11-8-22-19/h1-6,8-9,11,13,15H,7,10,12H2,(H,24,29)/t15-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385861
PNG
(US10287292, Compound 1.039)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cccc12)c1cn(cn1)-c1ccccc1
Show InChI InChI=1S/C21H20N6O/c28-21(18-14-27(15-23-18)17-5-2-1-3-6-17)24-16-8-11-26(13-16)20-19-7-4-10-25(19)12-9-22-20/h1-7,9-10,12,14-16H,8,11,13H2,(H,24,28)/t16-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385862
PNG
(US10287292, Compound 1.040)
Show SMILES Cc1cn2cccc2c(n1)N1CC[C@@H](C1)NC(=O)c1ncn(n1)-c1ccccc1
Show InChI InChI=1S/C21H21N7O/c1-15-12-26-10-5-8-18(26)20(23-15)27-11-9-16(13-27)24-21(29)19-22-14-28(25-19)17-6-3-2-4-7-17/h2-8,10,12,14,16H,9,11,13H2,1H3,(H,24,29)/t16-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385870
PNG
(US10287292, Compound 1.048)
Show SMILES Cc1ccc2nc(ncc2c1)C(=O)N[C@H]1CCN(C1)c1nccn2ccnc12
Show InChI InChI=1S/C20H19N7O/c1-13-2-3-16-14(10-13)11-23-17(25-16)20(28)24-15-4-7-27(12-15)19-18-21-5-8-26(18)9-6-22-19/h2-3,5-6,8-11,15H,4,7,12H2,1H3,(H,24,28)/t15-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385874
PNG
(US10287292, Compound 1.052)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cccc12)c1cnc(cn1)C1CC1
Show InChI InChI=1S/C19H20N6O/c26-19(16-11-21-15(10-22-16)13-3-4-13)23-14-5-8-25(12-14)18-17-2-1-7-24(17)9-6-20-18/h1-2,6-7,9-11,13-14H,3-5,8,12H2,(H,23,26)/t14-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385875
PNG
(US10287292, Compound 1.053)
Show SMILES Clc1ccc2nc(ncc2c1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C20H17ClN6O/c21-14-3-4-16-13(10-14)11-23-18(25-16)20(28)24-15-5-8-27(12-15)19-17-2-1-7-26(17)9-6-22-19/h1-4,6-7,9-11,15H,5,8,12H2,(H,24,28)/t15-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385887
PNG
(US10287292, Compound 1.065)
Show SMILES CCc1cnc(nc1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C18H20N6O/c1-2-13-10-20-16(21-11-13)18(25)22-14-5-8-24(12-14)17-15-4-3-7-23(15)9-6-19-17/h3-4,6-7,9-11,14H,2,5,8,12H2,1H3,(H,22,25)/t14-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385901
PNG
(US10287292, Compound 1.079)
Show SMILES OC1CCN(CC1)c1nc(cs1)C(=O)N[C@H]1CCN(C1)c1nccn2ccnc12
Show InChI InChI=1S/C19H23N7O2S/c27-14-2-7-25(8-3-14)19-23-15(12-29-19)18(28)22-13-1-6-26(11-13)17-16-20-4-9-24(16)10-5-21-17/h4-5,9-10,12-14,27H,1-3,6-8,11H2,(H,22,28)/t13-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385911
PNG
(US10287292, Compound 1.089)
Show SMILES Fc1ccc(cc1)-n1cnc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2cnnc12
Show InChI InChI=1S/C18H16FN9O/c19-12-1-3-14(4-2-12)28-10-21-15(25-28)18(29)23-13-5-7-26(9-13)16-17-24-22-11-27(17)8-6-20-16/h1-4,6,8,10-11,13H,5,7,9H2,(H,23,29)/t13-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385914
PNG
(US10287292, Compound 1.092)
Show SMILES Fc1ccc(cc1)-n1ccc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2ccnc12
Show InChI InChI=1S/C20H18FN7O/c21-14-1-3-16(4-2-14)28-10-6-17(25-28)20(29)24-15-5-9-27(13-15)19-18-22-7-11-26(18)12-8-23-19/h1-4,6-8,10-12,15H,5,9,13H2,(H,24,29)/t15-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385918
PNG
(US10287292, Compound 1.096)
Show SMILES Fc1ccc(cc1)-c1nc(cs1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C21H18FN5OS/c22-15-5-3-14(4-6-15)21-25-17(13-29-21)20(28)24-16-7-10-27(12-16)19-18-2-1-9-26(18)11-8-23-19/h1-6,8-9,11,13,16H,7,10,12H2,(H,24,28)/t16-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385920
PNG
(US10287292, Compound 1,098)
Show SMILES OC1CCC(CC1)c1nc(cs1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C21H25N5O2S/c27-16-5-3-14(4-6-16)21-24-17(13-29-21)20(28)23-15-7-10-26(12-15)19-18-2-1-9-25(18)11-8-22-19/h1-2,8-9,11,13-16,27H,3-7,10,12H2,(H,23,28)/t14?,15-,16?/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385937
PNG
(US10287292, Compound 1.115)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cccc12)c1ccn(n1)-c1ccccc1CC#N
Show InChI InChI=1S/C23H21N7O/c24-10-7-17-4-1-2-5-20(17)30-14-9-19(27-30)23(31)26-18-8-13-29(16-18)22-21-6-3-12-28(21)15-11-25-22/h1-6,9,11-12,14-15,18H,7-8,13,16H2,(H,26,31)/t18-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385940
PNG
(US10287292, Compound 1.118)
Show SMILES Cc1ccccc1-n1cnc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C21H21N7O/c1-15-5-2-3-6-17(15)28-14-23-19(25-28)21(29)24-16-8-11-27(13-16)20-18-7-4-10-26(18)12-9-22-20/h2-7,9-10,12,14,16H,8,11,13H2,1H3,(H,24,29)/t16-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385946
PNG
(US10287292, Compound 1.124)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cccc12)c1csc(n1)-c1ccccc1
Show InChI InChI=1S/C21H19N5OS/c27-20(17-14-28-21(24-17)15-5-2-1-3-6-15)23-16-8-11-26(13-16)19-18-7-4-10-25(18)12-9-22-19/h1-7,9-10,12,14,16H,8,11,13H2,(H,23,27)/t16-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385948
PNG
(US10287292, Compound 1.126)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cccc12)c1ncn(n1)-c1ccccc1
Show InChI InChI=1S/C20H19N7O/c28-20(18-22-14-27(24-18)16-5-2-1-3-6-16)23-15-8-11-26(13-15)19-17-7-4-10-25(17)12-9-21-19/h1-7,9-10,12,14-15H,8,11,13H2,(H,23,28)/t15-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385606
PNG
(US10287292, Compound 1.009)
Show SMILES CC(C)c1cn2cccc2c(n1)N1CC[C@@H](C1)NC(=O)c1csc(n1)N1CCC(O)CC1
Show InChI InChI=1S/C23H30N6O2S/c1-15(2)18-13-28-8-3-4-20(28)21(25-18)29-9-5-16(12-29)24-22(31)19-14-32-23(26-19)27-10-6-17(30)7-11-27/h3-4,8,13-17,30H,5-7,9-12H2,1-2H3,(H,24,31)/t16-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385627
PNG
(US10287292, Compound 1.022)
Show SMILES Cc1cn2cccc2c(n1)N1CC[C@@H](C1)NC(=O)c1ncn(n1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H20ClN7O/c1-14-11-27-9-2-3-18(27)20(24-14)28-10-8-16(12-28)25-21(30)19-23-13-29(26-19)17-6-4-15(22)5-7-17/h2-7,9,11,13,16H,8,10,12H2,1H3,(H,25,30)/t16-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385630
PNG
(US10287292, Compound 1.024)
Show SMILES Cc1cn2cccc2c(n1)N1CC[C@@H](C1)NC(=O)c1coc(n1)-c1ccccc1
Show InChI InChI=1S/C22H21N5O2/c1-15-12-26-10-5-8-19(26)20(23-15)27-11-9-17(13-27)24-21(28)18-14-29-22(25-18)16-6-3-2-4-7-16/h2-8,10,12,14,17H,9,11,13H2,1H3,(H,24,28)/t17-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385860
PNG
(US10287292, Compound 1.038)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cccc12)c1csc(n1)N1CCCC1
Show InChI InChI=1S/C19H22N6OS/c26-18(15-13-27-19(22-15)24-7-1-2-8-24)21-14-5-10-25(12-14)17-16-4-3-9-23(16)11-6-20-17/h3-4,6,9,11,13-14H,1-2,5,7-8,10,12H2,(H,21,26)/t14-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385890
PNG
(US10287292, Compound 1.068)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2ccnc12)c1csc(n1)-c1ccccc1
Show InChI InChI=1S/C20H18N6OS/c27-19(16-13-28-20(24-16)14-4-2-1-3-5-14)23-15-6-9-26(12-15)18-17-21-7-10-25(17)11-8-22-18/h1-5,7-8,10-11,13,15H,6,9,12H2,(H,23,27)/t15-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385891
PNG
(US10287292, Compound 1.069)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cnnc12)c1coc(n1)-c1ccccc1
Show InChI InChI=1S/C19H17N7O2/c27-18(15-11-28-19(23-15)13-4-2-1-3-5-13)22-14-6-8-25(10-14)16-17-24-21-12-26(17)9-7-20-16/h1-5,7,9,11-12,14H,6,8,10H2,(H,22,27)/t14-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385893
PNG
(US10287292, Compound 1.071)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cccc12)c1ncc(cn1)C1CC1
Show InChI InChI=1S/C19H20N6O/c26-19(17-21-10-14(11-22-17)13-3-4-13)23-15-5-8-25(12-15)18-16-2-1-7-24(16)9-6-20-18/h1-2,6-7,9-11,13,15H,3-5,8,12H2,(H,23,26)/t15-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385902
PNG
(US10287292, Compound 1,080)
Show SMILES Cc1ccccc1-c1nc(co1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C22H21N5O2/c1-15-5-2-3-6-17(15)22-25-18(14-29-22)21(28)24-16-8-11-27(13-16)20-19-7-4-10-26(19)12-9-23-20/h2-7,9-10,12,14,16H,8,11,13H2,1H3,(H,24,28)/t16-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385906
PNG
(US10287292, Compound 1.084)
Show SMILES Fc1ccc(cc1)-n1ccc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2cnnc12
Show InChI InChI=1S/C19H17FN8O/c20-13-1-3-15(4-2-13)28-9-6-16(25-28)19(29)23-14-5-8-26(11-14)17-18-24-22-12-27(18)10-7-21-17/h1-4,6-7,9-10,12,14H,5,8,11H2,(H,23,29)/t14-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385906
PNG
(US10287292, Compound 1.084)
Show SMILES Fc1ccc(cc1)-n1ccc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2cnnc12
Show InChI InChI=1S/C19H17FN8O/c20-13-1-3-15(4-2-13)28-9-6-16(25-28)19(29)23-14-5-8-26(11-14)17-18-24-22-12-27(18)10-7-21-17/h1-4,6-7,9-10,12,14H,5,8,11H2,(H,23,29)/t14-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385907
PNG
(US10287292, Compound 1.085)
Show SMILES Cc1ccc2nc(ncc2c1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C21H20N6O/c1-14-4-5-17-15(11-14)12-23-19(25-17)21(28)24-16-6-9-27(13-16)20-18-3-2-8-26(18)10-7-22-20/h2-5,7-8,10-12,16H,6,9,13H2,1H3,(H,24,28)/t16-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385913
PNG
(US10287292, Compound 1.091)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2ccnc12)c1ncn(n1)-c1ccccc1
Show InChI InChI=1S/C19H18N8O/c28-19(16-22-13-27(24-16)15-4-2-1-3-5-15)23-14-6-9-26(12-14)18-17-20-7-10-25(17)11-8-21-18/h1-5,7-8,10-11,13-14H,6,9,12H2,(H,23,28)/t14-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385916
PNG
(US10287292, Compound 1.094)
Show SMILES Cc1cc(Cl)ccc1-n1ccc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C22H21ClN6O/c1-15-13-16(23)4-5-19(15)29-11-7-18(26-29)22(30)25-17-6-10-28(14-17)21-20-3-2-9-27(20)12-8-24-21/h2-5,7-9,11-13,17H,6,10,14H2,1H3,(H,25,30)/t17-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385919
PNG
(US10287292, Compound 1.097)
Show SMILES Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3csc(n3)C3CCC(O)CC3)c12
Show InChI InChI=1S/C22H27N5O2S/c1-14-6-9-26-11-8-23-20(19(14)26)27-10-7-16(12-27)24-21(29)18-13-30-22(25-18)15-2-4-17(28)5-3-15/h6,8-9,11,13,15-17,28H,2-5,7,10,12H2,1H3,(H,24,29)/t15?,16-,17?/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385924
PNG
(US10287292, Compound 1.102)
Show SMILES Clc1ccc(cc1)-n1ccc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2ccnc12
Show InChI InChI=1S/C20H18ClN7O/c21-14-1-3-16(4-2-14)28-10-6-17(25-28)20(29)24-15-5-9-27(13-15)19-18-22-7-11-26(18)12-8-23-19/h1-4,6-8,10-12,15H,5,9,13H2,(H,24,29)/t15-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385943
PNG
(US10287292, Compound 1.121)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2ccnc12)C1NOC(=N1)c1ccccc1
Show InChI InChI=1S/C19H19N7O2/c27-18(15-23-19(28-24-15)13-4-2-1-3-5-13)22-14-6-9-26(12-14)17-16-20-7-10-25(16)11-8-21-17/h1-5,7-8,10-11,14-15,24H,6,9,12H2,(H,22,27)/t14-,15?/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385947
PNG
(US10287292, Compound 1.125)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cccc12)c1coc(n1)-c1ccccc1
Show InChI InChI=1S/C21H19N5O2/c27-20(17-14-28-21(24-17)15-5-2-1-3-6-15)23-16-8-11-26(13-16)19-18-7-4-10-25(18)12-9-22-19/h1-7,9-10,12,14,16H,8,11,13H2,(H,23,27)/t16-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385602
PNG
(US10287292, Compound 1.006)
Show SMILES Fc1ccccc1-n1cnc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2ccnc12
Show InChI InChI=1S/C19H17FN8O/c20-14-3-1-2-4-15(14)28-12-23-16(25-28)19(29)24-13-5-8-27(11-13)18-17-21-6-9-26(17)10-7-22-18/h1-4,6-7,9-10,12-13H,5,8,11H2,(H,24,29)/t13-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385610
PNG
(US10287292, Compound 1.012)
Show SMILES CCc1cn2cccc2c(n1)N1CC[C@@H](C1)NC(=O)c1csc(n1)N1CCC(O)CC1
Show InChI InChI=1S/C22H28N6O2S/c1-2-15-12-27-8-3-4-19(27)20(23-15)28-9-5-16(13-28)24-21(30)18-14-31-22(25-18)26-10-6-17(29)7-11-26/h3-4,8,12,14,16-17,29H,2,5-7,9-11,13H2,1H3,(H,24,30)/t16-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385614
PNG
(US10287292, Compound 1.014)
Show SMILES Fc1ccc(cc1F)-n1cnc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2ccnc12
Show InChI InChI=1S/C19H16F2N8O/c20-14-2-1-13(9-15(14)21)29-11-24-16(26-29)19(30)25-12-3-6-28(10-12)18-17-22-4-7-27(17)8-5-23-18/h1-2,4-5,7-9,11-12H,3,6,10H2,(H,25,30)/t12-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385818
PNG
(US10287292, Compound 1.034)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2ccnc12)c1csc(n1)N1CCCC1
Show InChI InChI=1S/C18H21N7OS/c26-17(14-12-27-18(22-14)24-6-1-2-7-24)21-13-3-8-25(11-13)16-15-19-4-9-23(15)10-5-20-16/h4-5,9-10,12-13H,1-3,6-8,11H2,(H,21,26)/t13-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385877
PNG
(US10287292, Compound 1.055)
Show SMILES CC1(O)CCN(CC1)c1nc(cs1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C21H26N6O2S/c1-21(29)5-10-26(11-6-21)20-24-16(14-30-20)19(28)23-15-4-9-27(13-15)18-17-3-2-8-25(17)12-7-22-18/h2-3,7-8,12,14-15,29H,4-6,9-11,13H2,1H3,(H,23,28)/t15-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385886
PNG
(US10287292, Compound 1.064)
Show SMILES CC(C)c1cnc(nc1)C(=O)N[C@H]1CCN(C1)c1nccn2ccnc12
Show InChI InChI=1S/C18H21N7O/c1-12(2)13-9-21-15(22-10-13)18(26)23-14-3-6-25(11-14)17-16-19-4-7-24(16)8-5-20-17/h4-5,7-10,12,14H,3,6,11H2,1-2H3,(H,23,26)/t14-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385888
PNG
(US10287292, Compound 1.066)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cnnc12)c1csc(n1)-c1ccccc1
Show InChI InChI=1S/C19H17N7OS/c27-18(15-11-28-19(23-15)13-4-2-1-3-5-13)22-14-6-8-25(10-14)16-17-24-21-12-26(17)9-7-20-16/h1-5,7,9,11-12,14H,6,8,10H2,(H,22,27)/t14-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385894
PNG
(US10287292, Compound 1.072)
Show SMILES OCC1(CCN(C1)c1nccn2cccc12)NC(=O)c1csc(n1)N1CCC(O)CC1
Show InChI InChI=1S/C21H26N6O3S/c28-14-21(5-10-27(13-21)18-17-2-1-7-25(17)11-6-22-18)24-19(30)16-12-31-20(23-16)26-8-3-15(29)4-9-26/h1-2,6-7,11-12,15,28-29H,3-5,8-10,13-14H2,(H,24,30)
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385911
PNG
(US10287292, Compound 1.089)
Show SMILES Fc1ccc(cc1)-n1cnc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2cnnc12
Show InChI InChI=1S/C18H16FN9O/c19-12-1-3-14(4-2-12)28-10-21-15(25-28)18(29)23-13-5-7-26(9-13)16-17-24-22-11-27(17)8-6-20-16/h1-4,6,8,10-11,13H,5,7,9H2,(H,23,29)/t13-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385913
PNG
(US10287292, Compound 1.091)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2ccnc12)c1ncn(n1)-c1ccccc1
Show InChI InChI=1S/C19H18N8O/c28-19(16-22-13-27(24-16)15-4-2-1-3-5-15)23-14-6-9-26(12-14)18-17-20-7-10-25(17)11-8-21-18/h1-5,7-8,10-11,13-14H,6,9,12H2,(H,23,28)/t14-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385923
PNG
(US10287292, Compound 1.101)
Show SMILES Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3ccn(n3)-c3ccccc3CC#N)c12
Show InChI InChI=1S/C24H23N7O/c1-17-7-12-29-15-11-26-23(22(17)29)30-13-8-19(16-30)27-24(32)20-9-14-31(28-20)21-5-3-2-4-18(21)6-10-25/h2-5,7,9,11-12,14-15,19H,6,8,13,16H2,1H3,(H,27,32)/t19-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385926
PNG
(US10287292, Compound 1.104)
Show SMILES Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3ccn(n3)-c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C22H21ClN6O/c1-15-6-10-27-13-9-24-21(20(15)27)28-11-7-17(14-28)25-22(30)19-8-12-29(26-19)18-4-2-16(23)3-5-18/h2-6,8-10,12-13,17H,7,11,14H2,1H3,(H,25,30)/t17-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385934
PNG
(US10287292, Compound 1.112)
Show SMILES Clc1ccc(cc1)-n1ccc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2cnnc12
Show InChI InChI=1S/C19H17ClN8O/c20-13-1-3-15(4-2-13)28-9-6-16(25-28)19(29)23-14-5-8-26(11-14)17-18-24-22-12-27(18)10-7-21-17/h1-4,6-7,9-10,12,14H,5,8,11H2,(H,23,29)/t14-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385936
PNG
(US10287292, Compound 1.114)
Show SMILES Fc1cc(ccc1Cl)-n1ccc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C21H18ClFN6O/c22-16-4-3-15(12-17(16)23)29-10-6-18(26-29)21(30)25-14-5-9-28(13-14)20-19-2-1-8-27(19)11-7-24-20/h1-4,6-8,10-12,14H,5,9,13H2,(H,25,30)/t14-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385617
PNG
(US10287292, Compound 1.015)
Show SMILES CCc1cn2cccc2c(n1)N1CC[C@@H](C1)NC(=O)c1ncn(n1)-c1ccccc1
Show InChI InChI=1S/C22H23N7O/c1-2-16-13-27-11-6-9-19(27)21(24-16)28-12-10-17(14-28)25-22(30)20-23-15-29(26-20)18-7-4-3-5-8-18/h3-9,11,13,15,17H,2,10,12,14H2,1H3,(H,25,30)/t17-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385618
PNG
(US10287292, Compound 1.016)
Show SMILES Fc1cccc(c1)-n1cnc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2ccnc12
Show InChI InChI=1S/C19H17FN8O/c20-13-2-1-3-15(10-13)28-12-23-16(25-28)19(29)24-14-4-7-27(11-14)18-17-21-5-8-26(17)9-6-22-18/h1-3,5-6,8-10,12,14H,4,7,11H2,(H,24,29)/t14-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385623
PNG
(US10287292, Compound 1.019)
Show SMILES Cc1ccc2nc(ncc2c1)C(=O)N[C@H]1CCN(C1)c1nc(C)cn2cccc12
Show InChI InChI=1S/C22H22N6O/c1-14-5-6-18-16(10-14)11-23-20(26-18)22(29)25-17-7-9-28(13-17)21-19-4-3-8-27(19)12-15(2)24-21/h3-6,8,10-12,17H,7,9,13H2,1-2H3,(H,25,29)/t17-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385871
PNG
(US10287292, Compound 1.049)
Show SMILES CN(C)c1cnc(cn1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C18H21N7O/c1-23(2)16-11-20-14(10-21-16)18(26)22-13-5-8-25(12-13)17-15-4-3-7-24(15)9-6-19-17/h3-4,6-7,9-11,13H,5,8,12H2,1-2H3,(H,22,26)/t13-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385896
PNG
(US10287292, Compound 1.074)
Show SMILES OCC1(CCN(C1)c1nccn2cccc12)NC(=O)c1ccn(n1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H21ClN6O2/c23-16-3-5-17(6-4-16)29-11-7-18(26-29)21(31)25-22(15-30)8-12-28(14-22)20-19-2-1-10-27(19)13-9-24-20/h1-7,9-11,13,30H,8,12,14-15H2,(H,25,31)
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ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385899
PNG
(US10287292, Compound 1.077)
Show SMILES CC(C)c1cnc(nc1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C19H22N6O/c1-13(2)14-10-21-17(22-11-14)19(26)23-15-5-8-25(12-15)18-16-4-3-7-24(16)9-6-20-18/h3-4,6-7,9-11,13,15H,5,8,12H2,1-2H3,(H,23,26)/t15-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385900
PNG
(US10287292, Compound 1.078)
Show SMILES OC1CCN(CC1)c1nc(cs1)C(=O)N[C@H]1CCN(C1)c1nccn2cnnc12
Show InChI InChI=1S/C18H22N8O2S/c27-13-2-6-24(7-3-13)18-22-14(10-29-18)17(28)21-12-1-5-25(9-12)15-16-23-20-11-26(16)8-4-19-15/h4,8,10-13,27H,1-3,5-7,9H2,(H,21,28)/t12-/m0/s1
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ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385905
PNG
(US10287292, Compound 1.083)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cccc12)c1nnc([nH]1)-c1ccccc1
Show InChI InChI=1/C20H19N7O/c28-20(18-23-17(24-25-18)14-5-2-1-3-6-14)22-15-8-11-27(13-15)19-16-7-4-10-26(16)12-9-21-19/h1-7,9-10,12,15H,8,11,13H2,(H,22,28)(H,23,24,25)/t15-/s2
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385907
PNG
(US10287292, Compound 1.085)
Show SMILES Cc1ccc2nc(ncc2c1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C21H20N6O/c1-14-4-5-17-15(11-14)12-23-19(25-17)21(28)24-16-6-9-27(13-16)20-18-3-2-8-26(18)10-7-22-20/h2-5,7-8,10-12,16H,6,9,13H2,1H3,(H,24,28)/t16-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385917
PNG
(US10287292, Compound 1.095)
Show SMILES Fc1ccc(cc1)-c1nc(co1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C21H18FN5O2/c22-15-5-3-14(4-6-15)21-25-17(13-29-21)20(28)24-16-7-10-27(12-16)19-18-2-1-9-26(18)11-8-23-19/h1-6,8-9,11,13,16H,7,10,12H2,(H,24,28)/t16-/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385919
PNG
(US10287292, Compound 1.097)
Show SMILES Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3csc(n3)C3CCC(O)CC3)c12
Show InChI InChI=1S/C22H27N5O2S/c1-14-6-9-26-11-8-23-20(19(14)26)27-10-7-16(12-27)24-21(29)18-13-30-22(25-18)15-2-4-17(28)5-3-15/h6,8-9,11,13,15-17,28H,2-5,7,10,12H2,1H3,(H,24,29)/t15?,16-,17?/m0/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385920
PNG
(US10287292, Compound 1,098)
Show SMILES OC1CCC(CC1)c1nc(cs1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C21H25N5O2S/c27-16-5-3-14(4-6-16)21-24-17(13-29-21)20(28)23-15-7-10-26(12-15)19-18-2-1-9-25(18)11-8-22-19/h1-2,8-9,11,13-16,27H,3-7,10,12H2,(H,23,28)/t14?,15-,16?/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385921
PNG
(US10287292, Compound 1.099)
Show SMILES Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3ccn(n3)-c3cccc(F)c3)c12
Show InChI InChI=1S/C22H21FN6O/c1-15-5-9-27-12-8-24-21(20(15)27)28-10-6-17(14-28)25-22(30)19-7-11-29(26-19)18-4-2-3-16(23)13-18/h2-5,7-9,11-13,17H,6,10,14H2,1H3,(H,25,30)/t17-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385924
PNG
(US10287292, Compound 1.102)
Show SMILES Clc1ccc(cc1)-n1ccc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2ccnc12
Show InChI InChI=1S/C20H18ClN7O/c21-14-1-3-16(4-2-14)28-10-6-17(25-28)20(29)24-15-5-9-27(13-15)19-18-22-7-11-26(18)12-8-23-19/h1-4,6-8,10-12,15H,5,9,13H2,(H,24,29)/t15-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385942
PNG
(US10287292, Compound 1.120)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cccc12)c1noc(n1)-c1ccccc1
Show InChI InChI=1S/C20H18N6O2/c27-19(17-23-20(28-24-17)14-5-2-1-3-6-14)22-15-8-11-26(13-15)18-16-7-4-10-25(16)12-9-21-18/h1-7,9-10,12,15H,8,11,13H2,(H,22,27)/t15-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385942
PNG
(US10287292, Compound 1.120)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cccc12)c1noc(n1)-c1ccccc1
Show InChI InChI=1S/C20H18N6O2/c27-19(17-23-20(28-24-17)14-5-2-1-3-6-14)22-15-8-11-26(13-15)18-16-7-4-10-25(16)12-9-21-18/h1-7,9-10,12,15H,8,11,13H2,(H,22,27)/t15-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385943
PNG
(US10287292, Compound 1.121)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2ccnc12)C1NOC(=N1)c1ccccc1
Show InChI InChI=1S/C19H19N7O2/c27-18(15-23-19(28-24-15)13-4-2-1-3-5-13)22-14-6-9-26(12-14)17-16-20-7-10-25(16)11-8-21-17/h1-5,7-8,10-11,14-15,24H,6,9,12H2,(H,22,27)/t14-,15?/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385945
PNG
(US10287292, Compound 1.123)
Show SMILES Cc1ccccc1-n1ccc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C22H22N6O/c1-16-5-2-3-6-19(16)28-13-9-18(25-28)22(29)24-17-8-12-27(15-17)21-20-7-4-11-26(20)14-10-23-21/h2-7,9-11,13-14,17H,8,12,15H2,1H3,(H,24,29)/t17-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385948
PNG
(US10287292, Compound 1.126)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cccc12)c1ncn(n1)-c1ccccc1
Show InChI InChI=1S/C20H19N7O/c28-20(18-22-14-27(24-18)16-5-2-1-3-6-16)23-15-8-11-26(13-15)19-17-7-4-10-25(17)12-9-21-19/h1-7,9-10,12,14-15H,8,11,13H2,(H,23,28)/t15-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385631
PNG
(US10287292, Compound 1.025)
Show SMILES Cc1cn2cccc2c(n1)N1CC[C@@H](C1)NC(=O)c1csc(n1)N1CCCC1
Show InChI InChI=1S/C20H24N6OS/c1-14-11-25-9-4-5-17(25)18(21-14)26-10-6-15(12-26)22-19(27)16-13-28-20(23-16)24-7-2-3-8-24/h4-5,9,11,13,15H,2-3,6-8,10,12H2,1H3,(H,22,27)/t15-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385633
PNG
(US10287292, Compound 1.026)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2ccnc12)c1csc(n1)N1CCC1
Show InChI InChI=1S/C17H19N7OS/c25-16(13-11-26-17(21-13)23-5-1-6-23)20-12-2-7-24(10-12)15-14-18-3-8-22(14)9-4-19-15/h3-4,8-9,11-12H,1-2,5-7,10H2,(H,20,25)/t12-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385699
PNG
(US10287292, Compound 1.028)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cccc12)c1ncc(cn1)C1CCCC1
Show InChI InChI=1S/C21H24N6O/c28-21(19-23-12-16(13-24-19)15-4-1-2-5-15)25-17-7-10-27(14-17)20-18-6-3-9-26(18)11-8-22-20/h3,6,8-9,11-13,15,17H,1-2,4-5,7,10,14H2,(H,25,28)/t17-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385738
PNG
(US10287292, Compound 1.030)
Show SMILES Cc1cn2cccc2c(n1)N1CC[C@@H](C1)NC(=O)c1cn(cn1)-c1ccccc1
Show InChI InChI=1S/C22H22N6O/c1-16-12-26-10-5-8-20(26)21(24-16)27-11-9-17(13-27)25-22(29)19-14-28(15-23-19)18-6-3-2-4-7-18/h2-8,10,12,14-15,17H,9,11,13H2,1H3,(H,25,29)/t17-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385823
PNG
(US10287292, Compound 1.036)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2ccnc12)c1cn(cn1)-c1ccccc1
Show InChI InChI=1S/C20H19N7O/c28-20(17-13-27(14-23-17)16-4-2-1-3-5-16)24-15-6-9-26(12-15)19-18-21-7-10-25(18)11-8-22-19/h1-5,7-8,10-11,13-15H,6,9,12H2,(H,24,28)/t15-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385863
PNG
(US10287292, Compound 1.041)
Show SMILES Cc1cn2cccc2c(n1)N1CC[C@@H](C1)NC(=O)c1ccn(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H21FN6O/c1-15-13-27-10-2-3-20(27)21(24-15)28-11-8-17(14-28)25-22(30)19-9-12-29(26-19)18-6-4-16(23)5-7-18/h2-7,9-10,12-13,17H,8,11,14H2,1H3,(H,25,30)/t17-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385866
PNG
(US10287292, Compound 1.044)
Show SMILES Cc1ccc2nc(ncc2c1)C(=O)N[C@H]1CCN(C1)c1nccn2cnnc12
Show InChI InChI=1S/C19H18N8O/c1-12-2-3-15-13(8-12)9-21-16(24-15)19(28)23-14-4-6-26(10-14)17-18-25-22-11-27(18)7-5-20-17/h2-3,5,7-9,11,14H,4,6,10H2,1H3,(H,23,28)/t14-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385868
PNG
(US10287292, Compound 1.046)
Show SMILES Cc1ccccc1-c1nc(cs1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C22H21N5OS/c1-15-5-2-3-6-17(15)22-25-18(14-29-22)21(28)24-16-8-11-27(13-16)20-19-7-4-10-26(19)12-9-23-20/h2-7,9-10,12,14,16H,8,11,13H2,1H3,(H,24,28)/t16-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385879
PNG
(US10287292, Compound 1.057)
Show SMILES Cc1ccccc1-n1ccc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2ccnc12
Show InChI InChI=1S/C21H21N7O/c1-15-4-2-3-5-18(15)28-11-7-17(25-28)21(29)24-16-6-10-27(14-16)20-19-22-8-12-26(19)13-9-23-20/h2-5,7-9,11-13,16H,6,10,14H2,1H3,(H,24,29)/t16-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385881
PNG
(US10287292, Compound 1.059)
Show SMILES OCC1(CCN(C1)c1nccn2ccnc12)NC(=O)c1ccn(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H20FN7O2/c22-15-1-3-16(4-2-15)29-9-5-17(26-29)20(31)25-21(14-30)6-10-28(13-21)19-18-23-7-11-27(18)12-8-24-19/h1-5,7-9,11-12,30H,6,10,13-14H2,(H,25,31)
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385899
PNG
(US10287292, Compound 1.077)
Show SMILES CC(C)c1cnc(nc1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C19H22N6O/c1-13(2)14-10-21-17(22-11-14)19(26)23-15-5-8-25(12-15)18-16-4-3-7-24(16)9-6-20-18/h3-4,6-7,9-11,13,15H,5,8,12H2,1-2H3,(H,23,26)/t15-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385900
PNG
(US10287292, Compound 1.078)
Show SMILES OC1CCN(CC1)c1nc(cs1)C(=O)N[C@H]1CCN(C1)c1nccn2cnnc12
Show InChI InChI=1S/C18H22N8O2S/c27-13-2-6-24(7-3-13)18-22-14(10-29-18)17(28)21-12-1-5-25(9-12)15-16-23-20-11-26(16)8-4-19-15/h4,8,10-13,27H,1-3,5-7,9H2,(H,21,28)/t12-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385912
PNG
(US10287292, Compound 1.090)
Show SMILES Fc1ccc(cc1)-n1cnc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2ccnc12
Show InChI InChI=1S/C19H17FN8O/c20-13-1-3-15(4-2-13)28-12-23-16(25-28)19(29)24-14-5-8-27(11-14)18-17-21-6-9-26(17)10-7-22-18/h1-4,6-7,9-10,12,14H,5,8,11H2,(H,24,29)/t14-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385916
PNG
(US10287292, Compound 1.094)
Show SMILES Cc1cc(Cl)ccc1-n1ccc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C22H21ClN6O/c1-15-13-16(23)4-5-19(15)29-11-7-18(26-29)22(30)25-17-6-10-28(14-17)21-20-3-2-9-27(20)12-8-24-21/h2-5,7-9,11-13,17H,6,10,14H2,1H3,(H,25,30)/t17-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385925
PNG
(US10287292, Compound 1.103)
Show SMILES Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3ccn(n3)-c3ccc(Cl)cc3C)c12
Show InChI InChI=1S/C23H23ClN6O/c1-15-5-9-28-12-8-25-22(21(15)28)29-10-6-18(14-29)26-23(31)19-7-11-30(27-19)20-4-3-17(24)13-16(20)2/h3-5,7-9,11-13,18H,6,10,14H2,1-2H3,(H,26,31)/t18-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385935
PNG
(US10287292, Compound 1.113)
Show SMILES Fc1cccc(c1)-n1ccc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C21H19FN6O/c22-15-3-1-4-17(13-15)28-11-7-18(25-28)21(29)24-16-6-10-27(14-16)20-19-5-2-9-26(19)12-8-23-20/h1-5,7-9,11-13,16H,6,10,14H2,(H,24,29)/t16-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385941
PNG
(US10287292, Compound 1.119)
Show SMILES Clc1ccc(cc1)-n1cnc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C20H18ClN7O/c21-14-3-5-16(6-4-14)28-13-23-18(25-28)20(29)24-15-7-10-27(12-15)19-17-2-1-9-26(17)11-8-22-19/h1-6,8-9,11,13,15H,7,10,12H2,(H,24,29)/t15-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385944
PNG
(US10287292, Compound 1.122)
Show SMILES Fc1ccc(cc1)-c1nc(co1)C(=O)N[C@H]1CCN(C1)c1nccn2cnnc12
Show InChI InChI=1S/C19H16FN7O2/c20-13-3-1-12(2-4-13)19-24-15(10-29-19)18(28)23-14-5-7-26(9-14)16-17-25-22-11-27(17)8-6-21-16/h1-4,6,8,10-11,14H,5,7,9H2,(H,23,28)/t14-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385949
PNG
(US10287292, Compound 1.127)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cnnc12)c1ncn(n1)-c1ccccc1
Show InChI InChI=1S/C18H17N9O/c28-18(15-20-11-27(24-15)14-4-2-1-3-5-14)22-13-6-8-25(10-13)16-17-23-21-12-26(17)9-7-19-16/h1-5,7,9,11-13H,6,8,10H2,(H,22,28)/t13-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385951
PNG
(US10287292, Compound 1.129)
Show SMILES Clc1ccc(cc1)-n1ccc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C21H19ClN6O/c22-15-3-5-17(6-4-15)28-12-8-18(25-28)21(29)24-16-7-11-27(14-16)20-19-2-1-10-26(19)13-9-23-20/h1-6,8-10,12-13,16H,7,11,14H2,(H,24,29)/t16-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385905
PNG
(US10287292, Compound 1.083)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cccc12)c1nnc([nH]1)-c1ccccc1
Show InChI InChI=1/C20H19N7O/c28-20(18-23-17(24-25-18)14-5-2-1-3-6-14)22-15-8-11-27(13-15)19-16-7-4-10-26(16)12-9-21-19/h1-7,9-10,12,15H,8,11,13H2,(H,22,28)(H,23,24,25)/t15-/s2
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n/an/a 1.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385930
PNG
(US10287292, Compound 1.108)
Show SMILES Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3csc(n3)-c3ccc(F)cc3)c12
Show InChI InChI=1S/C22H20FN5OS/c1-14-6-9-27-11-8-24-20(19(14)27)28-10-7-17(12-28)25-21(29)18-13-30-22(26-18)15-2-4-16(23)5-3-15/h2-6,8-9,11,13,17H,7,10,12H2,1H3,(H,25,29)/t17-/m0/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385925
PNG
(US10287292, Compound 1.103)
Show SMILES Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3ccn(n3)-c3ccc(Cl)cc3C)c12
Show InChI InChI=1S/C23H23ClN6O/c1-15-5-9-28-12-8-25-22(21(15)28)29-10-6-18(14-29)26-23(31)19-7-11-30(27-19)20-4-3-17(24)13-16(20)2/h3-5,7-9,11-13,18H,6,10,14H2,1-2H3,(H,26,31)/t18-/m0/s1
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US Patent
n/an/a 1.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385883
PNG
(US10287292, Compound 1.061)
Show SMILES CC(C)c1cnc(nc1)C(=O)N[C@H]1CCN(C1)c1nccn2cnnc12
Show InChI InChI=1S/C17H20N8O/c1-11(2)12-7-19-14(20-8-12)17(26)22-13-3-5-24(9-13)15-16-23-21-10-25(16)6-4-18-15/h4,6-8,10-11,13H,3,5,9H2,1-2H3,(H,22,26)/t13-/m0/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385600
PNG
(US10287292, Compound 1.004)
Show SMILES Cc1ccc(cc1)-n1cnc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2ccnc12
Show InChI InChI=1S/C20H20N8O/c1-14-2-4-16(5-3-14)28-13-23-17(25-28)20(29)24-15-6-9-27(12-15)19-18-21-7-10-26(18)11-8-22-19/h2-5,7-8,10-11,13,15H,6,9,12H2,1H3,(H,24,29)/t15-/m0/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385933
PNG
(US10287292, Compound 1.111)
Show SMILES Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3noc(n3)-c3ccccc3)c12
Show InChI InChI=1S/C21H20N6O2/c1-14-7-10-26-12-9-22-19(17(14)26)27-11-8-16(13-27)23-20(28)18-24-21(29-25-18)15-5-3-2-4-6-15/h2-7,9-10,12,16H,8,11,13H2,1H3,(H,23,28)/t16-/m0/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385929
PNG
(US10287292, Compound 1.107)
Show SMILES Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3coc(n3)-c3ccccc3)c12
Show InChI InChI=1S/C22H21N5O2/c1-15-7-10-26-12-9-23-20(19(15)26)27-11-8-17(13-27)24-21(28)18-14-29-22(25-18)16-5-3-2-4-6-16/h2-7,9-10,12,14,17H,8,11,13H2,1H3,(H,24,28)/t17-/m0/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385903
PNG
(US10287292, Compound 1.081)
Show SMILES Clc1ccc(nc1)-n1ccc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C20H18ClN7O/c21-14-3-4-18(23-12-14)28-10-6-16(25-28)20(29)24-15-5-9-27(13-15)19-17-2-1-8-26(17)11-7-22-19/h1-4,6-8,10-12,15H,5,9,13H2,(H,24,29)/t15-/m0/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385607
PNG
(US10287292, Compound 1.010)
Show SMILES Fc1ccc(cc1)-n1cnc(n1)C(=O)N[C@@H]1CCN(C1)c1nccn2ccnc12
Show InChI InChI=1S/C19H17FN8O/c20-13-1-3-15(4-2-13)28-12-23-16(25-28)19(29)24-14-5-8-27(11-14)18-17-21-6-9-26(17)10-7-22-18/h1-4,6-7,9-10,12,14H,5,8,11H2,(H,24,29)/t14-/m1/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385928
PNG
(US10287292, Compound 1.106)
Show SMILES Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3ccn(n3)-c3ccc(F)cc3)c12
Show InChI InChI=1S/C22H21FN6O/c1-15-6-10-27-13-9-24-21(20(15)27)28-11-7-17(14-28)25-22(30)19-8-12-29(26-19)18-4-2-16(23)3-5-18/h2-6,8-10,12-13,17H,7,11,14H2,1H3,(H,25,30)/t17-/m0/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385941
PNG
(US10287292, Compound 1.119)
Show SMILES Clc1ccc(cc1)-n1cnc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C20H18ClN7O/c21-14-3-5-16(6-4-14)28-13-23-18(25-28)20(29)24-15-7-10-27(12-15)19-17-2-1-9-26(17)11-8-22-19/h1-6,8-9,11,13,15H,7,10,12H2,(H,24,29)/t15-/m0/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385927
PNG
(US10287292, Compound 1.105)
Show SMILES Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3csc(n3)-c3ccccc3)c12
Show InChI InChI=1S/C22H21N5OS/c1-15-7-10-26-12-9-23-20(19(15)26)27-11-8-17(13-27)24-21(28)18-14-29-22(25-18)16-5-3-2-4-6-16/h2-7,9-10,12,14,17H,8,11,13H2,1H3,(H,24,28)/t17-/m0/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385885
PNG
(US10287292, Compound 1.063)
Show SMILES Cc1cnc(nc1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C17H18N6O/c1-12-9-19-15(20-10-12)17(24)21-13-4-7-23(11-13)16-14-3-2-6-22(14)8-5-18-16/h2-3,5-6,8-10,13H,4,7,11H2,1H3,(H,21,24)/t13-/m0/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385897
PNG
(US10287292, Compound 1.075)
Show SMILES OC1CCN(CC1)c1cnc(cn1)C(=O)N[C@H]1CCN(C1)c1nccn2ccnc12
Show InChI InChI=1S/C20H24N8O2/c29-15-2-7-26(8-3-15)17-12-23-16(11-24-17)20(30)25-14-1-6-28(13-14)19-18-21-4-9-27(18)10-5-22-19/h4-5,9-12,14-15,29H,1-3,6-8,13H2,(H,25,30)/t14-/m0/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385902
PNG
(US10287292, Compound 1,080)
Show SMILES Cc1ccccc1-c1nc(co1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C22H21N5O2/c1-15-5-2-3-6-17(15)22-25-18(14-29-22)21(28)24-16-8-11-27(13-16)20-19-7-4-10-26(19)12-9-23-20/h2-7,9-10,12,14,16H,8,11,13H2,1H3,(H,24,28)/t16-/m0/s1
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US Patent
n/an/a 1.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385934
PNG
(US10287292, Compound 1.112)
Show SMILES Clc1ccc(cc1)-n1ccc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2cnnc12
Show InChI InChI=1S/C19H17ClN8O/c20-13-1-3-15(4-2-13)28-9-6-16(25-28)19(29)23-14-5-8-26(11-14)17-18-24-22-12-27(18)10-7-21-17/h1-4,6-7,9-10,12,14H,5,8,11H2,(H,23,29)/t14-/m0/s1
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US Patent
n/an/a 1.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385938
PNG
(US10287292, Compound 1.116)
Show SMILES Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3coc(n3)-c3ccc(F)cc3)c12
Show InChI InChI=1S/C22H20FN5O2/c1-14-6-9-27-11-8-24-20(19(14)27)28-10-7-17(12-28)25-21(29)18-13-30-22(26-18)15-2-4-16(23)5-3-15/h2-6,8-9,11,13,17H,7,10,12H2,1H3,(H,25,29)/t17-/m0/s1
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US Patent
n/an/a 1.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385908
PNG
(US10287292, Compound 1.086)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2ccnc12)c1ccn(n1)C1CCOCC1
Show InChI InChI=1S/C19H23N7O2/c27-19(16-2-8-26(23-16)15-3-11-28-12-4-15)22-14-1-7-25(13-14)18-17-20-5-9-24(17)10-6-21-18/h2,5-6,8-10,14-15H,1,3-4,7,11-13H2,(H,22,27)/t14-/m0/s1
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US Patent
n/an/a 1.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385923
PNG
(US10287292, Compound 1.101)
Show SMILES Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3ccn(n3)-c3ccccc3CC#N)c12
Show InChI InChI=1S/C24H23N7O/c1-17-7-12-29-15-11-26-23(22(17)29)30-13-8-19(16-30)27-24(32)20-9-14-31(28-20)21-5-3-2-4-18(21)6-10-25/h2-5,7,9,11-12,14-15,19H,6,8,13,16H2,1H3,(H,27,32)/t19-/m0/s1
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US Patent
n/an/a 1.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385603
PNG
(US10287292, Compound 1.007)
Show SMILES CC(C)c1cn2cccc2c(n1)N1CC[C@@H](C1)NC(=O)c1ncn(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C23H24FN7O/c1-15(2)19-13-29-10-3-4-20(29)22(27-19)30-11-9-17(12-30)26-23(32)21-25-14-31(28-21)18-7-5-16(24)6-8-18/h3-8,10,13-15,17H,9,11-12H2,1-2H3,(H,26,32)/t17-/m0/s1
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US Patent
n/an/a 1.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385696
PNG
(US10287292, Compound 1.027)
Show SMILES O=C(NC1CCN(C1)c1nccn2ccnc12)c1ncn(n1)-c1ccccc1
Show InChI InChI=1S/C19H18N8O/c28-19(16-22-13-27(24-16)15-4-2-1-3-5-15)23-14-6-9-26(12-14)18-17-20-7-10-25(17)11-8-21-18/h1-5,7-8,10-11,13-14H,6,9,12H2,(H,23,28)
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US Patent
n/an/a 1.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385908
PNG
(US10287292, Compound 1.086)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2ccnc12)c1ccn(n1)C1CCOCC1
Show InChI InChI=1S/C19H23N7O2/c27-19(16-2-8-26(23-16)15-3-11-28-12-4-15)22-14-1-7-25(13-14)18-17-20-5-9-24(17)10-6-21-18/h2,5-6,8-10,14-15H,1,3-4,7,11-13H2,(H,22,27)/t14-/m0/s1
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US Patent
n/an/a 1.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385931
PNG
(US10287292, Compound 1.109)
Show SMILES Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3ccn(n3)-c3ccccc3C)c12
Show InChI InChI=1S/C23H24N6O/c1-16-5-3-4-6-20(16)29-13-9-19(26-29)23(30)25-18-8-12-28(15-18)22-21-17(2)7-11-27(21)14-10-24-22/h3-7,9-11,13-14,18H,8,12,15H2,1-2H3,(H,25,30)/t18-/m0/s1
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US Patent
n/an/a 1.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385932
PNG
(US10287292, Compound 1.110)
Show SMILES Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3ncc(cn3)-c3ccccc3)c12
Show InChI InChI=1S/C23H22N6O/c1-16-7-10-28-12-9-24-22(20(16)28)29-11-8-19(15-29)27-23(30)21-25-13-18(14-26-21)17-5-3-2-4-6-17/h2-7,9-10,12-14,19H,8,11,15H2,1H3,(H,27,30)/t19-/m0/s1
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US Patent
n/an/a 1.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385604
PNG
(US10287292, Compound 1.008)
Show SMILES CC(C)c1cn2cccc2c(n1)N1CC[C@@H](C1)NC(=O)c1ncn(n1)-c1ccccc1
Show InChI InChI=1S/C23H25N7O/c1-16(2)19-14-28-11-6-9-20(28)22(26-19)29-12-10-17(13-29)25-23(31)21-24-15-30(27-21)18-7-4-3-5-8-18/h3-9,11,14-17H,10,12-13H2,1-2H3,(H,25,31)/t17-/m0/s1
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US Patent
n/an/a 1.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385817
PNG
(US10287292, Compound 1.033)
Show SMILES CC(O)c1cnc(nc1)C(=O)N[C@H]1CCN(C1)c1nccn2cccc12
Show InChI InChI=1S/C18H20N6O2/c1-12(25)13-9-20-16(21-10-13)18(26)22-14-4-7-24(11-14)17-15-3-2-6-23(15)8-5-19-17/h2-3,5-6,8-10,12,14,25H,4,7,11H2,1H3,(H,22,26)/t12?,14-/m0/s1
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US Patent
n/an/a 1.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385878
PNG
(US10287292, Compound 1.056)
Show SMILES CC1(O)CCN(CC1)c1nc(cs1)C(=O)N[C@H]1CCN(C1)c1nccn2ccnc12
Show InChI InChI=1S/C20H25N7O2S/c1-20(29)3-8-26(9-4-20)19-24-15(13-30-19)18(28)23-14-2-7-27(12-14)17-16-21-5-10-25(16)11-6-22-17/h5-6,10-11,13-14,29H,2-4,7-9,12H2,1H3,(H,23,28)/t14-/m0/s1
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US Patent
n/an/a 1.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385904
PNG
(US10287292, Compound 1.082)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cccc12)c1noc(n1)C1CCOCC1
Show InChI InChI=1S/C19H22N6O3/c26-18(16-22-19(28-23-16)13-4-10-27-11-5-13)21-14-3-8-25(12-14)17-15-2-1-7-24(15)9-6-20-17/h1-2,6-7,9,13-14H,3-5,8,10-12H2,(H,21,26)/t14-/m0/s1
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US Patent
n/an/a 1.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385909
PNG
(US10287292, Compound 1.087)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cnnc12)c1ccn(n1)C1CCOCC1
Show InChI InChI=1S/C18H22N8O2/c27-18(15-2-7-26(23-15)14-3-9-28-10-4-14)21-13-1-6-24(11-13)16-17-22-20-12-25(17)8-5-19-16/h2,5,7-8,12-14H,1,3-4,6,9-11H2,(H,21,27)/t13-/m0/s1
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US Patent
n/an/a 1.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385909
PNG
(US10287292, Compound 1.087)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2cnnc12)c1ccn(n1)C1CCOCC1
Show InChI InChI=1S/C18H22N8O2/c27-18(15-2-7-26(23-15)14-3-9-28-10-4-14)21-13-1-6-24(11-13)16-17-22-20-12-25(17)8-5-19-16/h2,5,7-8,12-14H,1,3-4,6,9-11H2,(H,21,27)/t13-/m0/s1
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n/an/a>2.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
Target compounds can be tested to determine their ability to bind with CXCR7 sites on MCF-7 and/or MDA-MB-435S CXCR7 transfected cells. Efficiency-ma...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385598
PNG
(US10287292, Compound 1.002)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2ccnc12)c1ncn(n1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C20H17N9O/c21-11-14-1-3-16(4-2-14)29-13-24-17(26-29)20(30)25-15-5-8-28(12-15)19-18-22-6-9-27(18)10-7-23-19/h1-4,6-7,9-10,13,15H,5,8,12H2,(H,25,30)/t15-/m0/s1
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n/an/a>2.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385865
PNG
(US10287292, Compound 1.043)
Show SMILES OC(=O)C1(CCN(C1)c1nccn2cccc12)NC(=O)c1ccn(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H19FN6O3/c23-15-3-5-16(6-4-15)29-11-7-17(26-29)20(30)25-22(21(31)32)8-12-28(14-22)19-18-2-1-10-27(18)13-9-24-19/h1-7,9-11,13H,8,12,14H2,(H,25,30)(H,31,32)
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n/an/a>2.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385897
PNG
(US10287292, Compound 1.075)
Show SMILES OC1CCN(CC1)c1cnc(cn1)C(=O)N[C@H]1CCN(C1)c1nccn2ccnc12
Show InChI InChI=1S/C20H24N8O2/c29-15-2-7-26(8-3-15)17-12-23-16(11-24-17)20(30)25-14-1-6-28(13-14)19-18-21-4-9-27(18)10-5-22-19/h4-5,9-12,14-15,29H,1-3,6-8,13H2,(H,25,30)/t14-/m0/s1
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n/an/a>2.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385622
PNG
(US10287292, Compound 1.018)
Show SMILES O=C(N[C@H]1CCN(C1)c1nccn2nccc12)c1ncn(n1)-c1ccccc1
Show InChI InChI=1S/C19H18N8O/c28-19(17-21-13-27(24-17)15-4-2-1-3-5-15)23-14-7-10-25(12-14)18-16-6-8-22-26(16)11-9-20-18/h1-6,8-9,11,13-14H,7,10,12H2,(H,23,28)/t14-/m0/s1
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n/an/a>2.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385869
PNG
(US10287292, Compound 1.047)
Show SMILES O[C@@H]1CC(CCC11CC1)c1nc(cs1)C(=O)N[C@H]1CCN(C1)c1nccn2ccnc12
Show InChI InChI=1S/C22H26N6O2S/c29-17-11-14(1-3-22(17)4-5-22)21-26-16(13-31-21)20(30)25-15-2-8-28(12-15)19-18-23-6-9-27(18)10-7-24-19/h6-7,9-10,13-15,17,29H,1-5,8,11-12H2,(H,25,30)/t14?,15-,17+/m0/s1
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n/an/a>2.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385926
PNG
(US10287292, Compound 1.104)
Show SMILES Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3ccn(n3)-c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C22H21ClN6O/c1-15-6-10-27-13-9-24-21(20(15)27)28-11-7-17(14-28)25-22(30)19-8-12-29(26-19)18-4-2-16(23)3-5-18/h2-6,8-10,12-13,17H,7,11,14H2,1H3,(H,25,30)/t17-/m0/s1
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n/an/a>2.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385609
PNG
(US10287292, Compound 1.011)
Show SMILES OC1CCN(CC1)c1ccc(nn1)C(=O)N[C@H]1CCN(C1)c1nccn2ccnc12
Show InChI InChI=1S/C20H24N8O2/c29-15-4-9-26(10-5-15)17-2-1-16(24-25-17)20(30)23-14-3-8-28(13-14)19-18-21-6-11-27(18)12-7-22-19/h1-2,6-7,11-12,14-15,29H,3-5,8-10,13H2,(H,23,30)/t14-/m0/s1
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a>2.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385601
PNG
(US10287292, Compound 1.005)
Show SMILES CS(=O)(=O)c1ccc(cc1)-n1cnc(n1)C(=O)N[C@H]1CCN(C1)c1nccn2ccnc12
Show InChI InChI=1S/C20H20N8O3S/c1-32(30,31)16-4-2-15(3-5-16)28-13-23-17(25-28)20(29)24-14-6-9-27(12-14)19-18-21-7-10-26(18)11-8-22-19/h2-5,7-8,10-11,13-14H,6,9,12H2,1H3,(H,24,29)/t14-/m0/s1
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a>2.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 7 (CXCR7)


(Homo sapiens (Human))		BDBM385922
PNG
(US10287292, Compound 1.100)
Show SMILES Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3ccn(n3)-c3ccc(Cl)c(F)c3)c12
Show InChI InChI=1S/C22H20ClFN6O/c1-14-4-8-28-11-7-25-21(20(14)28)29-9-5-15(13-29)26-22(31)19-6-10-30(27-19)16-2-3-17(23)18(24)12-16/h2-4,6-8,10-12,15H,5,9,13H2,1H3,(H,26,31)/t15-/m0/s1
UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a>2.50E+3n/an/an/an/an/an/a



ChemoCentryx, Inc.

US Patent


Assay Description
In order to more properly assess the binding efficacy of the compounds, radioligand binding assays were carried out in the presence of 100% human ser...

US Patent US10287292 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%