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Patent code US10287293

Compile Data Set for Download or QSAR
Found 45 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385987
PNG
((R)- or (S)-5- (hydroxymethyl)-2- methyl-7-(1-(4-(...)
Show SMILES CC(c1nc(CO)c2n1nc(C)[nH]c2=O)c1ccc(cc1)C1(C)CC1
PDB

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US Patent
0.400n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385981
PNG
((R)- or (S)-7-(1-(2- fluoro-4- (trifluoromethyl) p...)
Show SMILES CC(c1nc(CO)c2n1nc(C)[nH]c2=O)c1ccc(cc1F)C(F)(F)F
PDB

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0.800n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385968
PNG
((R)- or (S)-3- (1-(3- Fluoro- 4- (trifluoro- meth...)
Show SMILES CC(c1nn(CCF)c2c1nc(C)[nH]c2=O)c1ccc(c(F)c1)C(F)(F)F
PDB

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0.900n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385985
PNG
((R)- or (S)-7-(1-(3- fluoro-4- (trifluoromethyl) p...)
Show SMILES CC(c1nc(CO)c2n1nc(C)[nH]c2=O)c1ccc(c(F)c1)C(F)(F)F
PDB

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1n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM385968
PNG
((R)- or (S)-3- (1-(3- Fluoro- 4- (trifluoro- meth...)
Show SMILES CC(c1nn(CCF)c2c1nc(C)[nH]c2=O)c1ccc(c(F)c1)C(F)(F)F
PDB

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US Patent
1n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385958
PNG
((R)- or (S)-3- (1-(3- Fluoro- 4- (trifluoro- meth...)
Show SMILES CC(c1nn(CCO)c2c1nc(C)[nH]c2=O)c1ccc(c(F)c1)C(F)(F)F
PDB

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US Patent
1.10n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385979
PNG
(US10287293, Example 28 | US10287293, Example 29)
Show SMILES C[C@@H](c1nc(CO)c2n1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F
PDB

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US Patent
1.20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385983
PNG
((R)- or (S)-5- (hydroxymethyl)-2- methyl-7-(1-(4- ...)
Show SMILES CC(c1nc(CO)c2n1nc(C)[nH]c2=O)c1ccc(OC(F)(F)F)cc1
PDB

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1.20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385966
PNG
((R)- or (S)-3- (1-(4- (tert- Butyl) phenyl) ethyl...)
Show SMILES CC(c1nn(CCF)c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(C)(C)C
PDB

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1.30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385954
PNG
(US10287293, Example 3 | US10287293, Example 4)
Show SMILES C[C@H](c1nn(CCO)c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F
PDB

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1.70n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385991
PNG
(US10287293, Example 40)
Show SMILES C[C@@H](c1nc(CCO)c2n1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F
PDB

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1.70n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385964
PNG
(US10287293, Example 13 | US10287293, Example 14)
Show SMILES C[C@@H](c1nn(CCF)c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F
PDB

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1.80n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385956
PNG
((R)- or (S)-3-(1- (4-(tert- Butyl) phenyl) ethyl)...)
Show SMILES CC(c1nn(CCO)c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(C)(C)C
PDB

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2.70n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385989
PNG
(US10287293, Example 38)
Show SMILES CC(c1nc(CC#N)c2n1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F
PDB

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6.10n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM385962
PNG
(US10287293, Example 11 | US10287293, Example 12)
Show SMILES C[C@@H](c1nn(CC(F)(F)F)c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F
PDB

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6.30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385974
PNG
(US10287293, Example 23 | US10287293, Example 24)
Show SMILES C[C@@H](CO)n1nc([C@@H](C)c2ccc(cc2)C(F)(F)F)c2nc(C)[nH]c(=O)c12
PDB

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6.70n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385962
PNG
(US10287293, Example 11 | US10287293, Example 12)
Show SMILES C[C@@H](c1nn(CC(F)(F)F)c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F
PDB

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7n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385952
PNG
(US10287293, Example 1 | US10287293, Example 2)
Show SMILES C[C@@H](c1n[nH]c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C15H11F3N4O/c1-7(9-3-5-10(6-4-9)15(16,17)18)11-12-13(22-21-11)14(23)20-8(2)19-12/h3-7H,1-2H3/t7-/m1/s1
PDB

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15.2n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385972
PNG
(US10287293, Example 21 | US10287293, Example 22)
Show SMILES C[C@H](CO)n1nc([C@@H](C)c2ccc(cc2)C(F)(F)F)c2nc(C)[nH]c(=O)c12
PDB

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15.6n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385977
PNG
(US10287293, Example 26 | US10287293, Example 27)
Show SMILES C[C@@H](c1nc(C)c2n1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F
PDB

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17.2n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM385952
PNG
(US10287293, Example 1 | US10287293, Example 2)
Show SMILES C[C@@H](c1n[nH]c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C15H11F3N4O/c1-7(9-3-5-10(6-4-9)15(16,17)18)11-12-13(22-21-11)14(23)20-8(2)19-12/h3-7H,1-2H3/t7-/m1/s1
PDB

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17.8n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM385977
PNG
(US10287293, Example 26 | US10287293, Example 27)
Show SMILES C[C@@H](c1nc(C)c2n1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F
PDB

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21n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385968
PNG
((R)- or (S)-3- (1-(3- Fluoro- 4- (trifluoro- meth...)
Show SMILES CC(c1nn(CCF)c2c1nc(C)[nH]c2=O)c1ccc(c(F)c1)C(F)(F)F
PDB

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24.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385964
PNG
(US10287293, Example 13 | US10287293, Example 14)
Show SMILES C[C@@H](c1nn(CCF)c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F
PDB

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26.8n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385958
PNG
((R)- or (S)-3- (1-(3- Fluoro- 4- (trifluoro- meth...)
Show SMILES CC(c1nn(CCO)c2c1nc(C)[nH]c2=O)c1ccc(c(F)c1)C(F)(F)F
PDB

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32.1n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385976
PNG
(US10287293, Example 25)
Show SMILES CC(c1nn(C)c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F
PDB

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60.9n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385983
PNG
((R)- or (S)-5- (hydroxymethyl)-2- methyl-7-(1-(4- ...)
Show SMILES CC(c1nc(CO)c2n1nc(C)[nH]c2=O)c1ccc(OC(F)(F)F)cc1
PDB

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62.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385954
PNG
(US10287293, Example 3 | US10287293, Example 4)
Show SMILES C[C@H](c1nn(CCO)c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F
PDB

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64.7n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM385976
PNG
(US10287293, Example 25)
Show SMILES CC(c1nn(C)c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F
PDB

UniProtKB/TrEMBL

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US Patent
70.3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385966
PNG
((R)- or (S)-3- (1-(4- (tert- Butyl) phenyl) ethyl...)
Show SMILES CC(c1nn(CCF)c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(C)(C)C
PDB

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82.9n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385990
PNG
(US10287293, Example 39)
Show SMILES C[C@H](c1nc(CCO)c2n1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F
PDB

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90.3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385987
PNG
((R)- or (S)-5- (hydroxymethyl)-2- methyl-7-(1-(4-(...)
Show SMILES CC(c1nc(CO)c2n1nc(C)[nH]c2=O)c1ccc(cc1)C1(C)CC1
PDB

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109n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385956
PNG
((R)- or (S)-3-(1- (4-(tert- Butyl) phenyl) ethyl)...)
Show SMILES CC(c1nn(CCO)c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(C)(C)C
PDB

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125n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385974
PNG
(US10287293, Example 23 | US10287293, Example 24)
Show SMILES C[C@@H](CO)n1nc([C@@H](C)c2ccc(cc2)C(F)(F)F)c2nc(C)[nH]c(=O)c12
PDB

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142n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM385962
PNG
(US10287293, Example 11 | US10287293, Example 12)
Show SMILES C[C@@H](c1nn(CC(F)(F)F)c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F
PDB

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178n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385981
PNG
((R)- or (S)-7-(1-(2- fluoro-4- (trifluoromethyl) p...)
Show SMILES CC(c1nc(CO)c2n1nc(C)[nH]c2=O)c1ccc(cc1F)C(F)(F)F
PDB

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200n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385960
PNG
((R)- or (S)-3- (1-(2- Fluoro- 3- (trifluoro- meth...)
Show SMILES CC(c1nn(CCO)c2c1nc(C)[nH]c2=O)c1cccc(c1F)C(F)(F)F
PDB

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206n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385985
PNG
((R)- or (S)-7-(1-(3- fluoro-4- (trifluoromethyl) p...)
Show SMILES CC(c1nc(CO)c2n1nc(C)[nH]c2=O)c1ccc(c(F)c1)C(F)(F)F
PDB

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216n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385972
PNG
(US10287293, Example 21 | US10287293, Example 22)
Show SMILES C[C@H](CO)n1nc([C@@H](C)c2ccc(cc2)C(F)(F)F)c2nc(C)[nH]c(=O)c12
PDB

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239n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM385952
PNG
(US10287293, Example 1 | US10287293, Example 2)
Show SMILES C[C@@H](c1n[nH]c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C15H11F3N4O/c1-7(9-3-5-10(6-4-9)15(16,17)18)11-12-13(22-21-11)14(23)20-8(2)19-12/h3-7H,1-2H3/t7-/m1/s1
PDB

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293n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385979
PNG
(US10287293, Example 28 | US10287293, Example 29)
Show SMILES C[C@@H](c1nc(CO)c2n1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F
PDB

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298n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385970
PNG
(US10287293, Example 19 | US10287293, Example 20)
Show SMILES C[C@H](c1nn(CCC(F)(F)F)c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F
PDB

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324n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385970
PNG
(US10287293, Example 19 | US10287293, Example 20)
Show SMILES C[C@H](c1nn(CCC(F)(F)F)c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F
PDB

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521n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM385977
PNG
(US10287293, Example 26 | US10287293, Example 27)
Show SMILES C[C@@H](c1nc(C)c2n1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F
PDB

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779n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM385960
PNG
((R)- or (S)-3- (1-(2- Fluoro- 3- (trifluoro- meth...)
Show SMILES CC(c1nn(CCO)c2c1nc(C)[nH]c2=O)c1cccc(c1F)C(F)(F)F
PDB

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2.80E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10287293 (2019)


BindingDB Entry DOI: 10.7270/Q2G1634M
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%