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Patent code US10292981

Compile Data Set for Download or QSAR
Found 53 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-2


(Homo sapiens (Human))
BDBM387262
PNG
(N-(5′- (5,5-Dimethyl-4-oxo- 4,5-dihydroisoxa...)
Show SMILES COc1ccc(cc1-c1ccc(NC(=O)c2snnc2C)cc1)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C22H20N4O4S/c1-12-19(31-26-24-12)21(28)23-15-8-5-13(6-9-15)16-11-14(7-10-17(16)29-4)18-20(27)22(2,3)30-25-18/h5-11H,1-4H3,(H,23,28)
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n/an/a<100n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387266
PNG
(N-(5′- (4-Ethyl-5-oxo-4,5- dihydro-1,3,4- ...)
Show SMILES CCn1nc(oc1=O)-c1ccc(C)c(c1)-c1ccc(NC(=O)c2c(F)cccc2F)cc1
Show InChI InChI=1S/C24H19F2N3O3/c1-3-29-24(31)32-23(28-29)16-8-7-14(2)18(13-16)15-9-11-17(12-10-15)27-22(30)21-19(25)5-4-6-20(21)26/h4-13H,3H2,1-2H3,(H,27,30)
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n/an/a<100n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387276
PNG
(5-(5- (5,5-Dimethyl-4-oxo- 4,5-dihydroisoxazol- 3-...)
Show SMILES CCc1ccc(cc1-c1ccc(s1)C(=O)Nc1ccncc1C)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C24H23N3O3S/c1-5-15-6-7-16(21-22(28)24(3,4)30-27-21)12-17(15)19-8-9-20(31-19)23(29)26-18-10-11-25-13-14(18)2/h6-13H,5H2,1-4H3,(H,25,26,29)
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n/an/a<100n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387271
PNG
(2,6- Difluoro-N-(5-(2- methoxy-5-(4- methyl-5-oxo-...)
Show SMILES COc1ccc(cc1-c1cnc(NC(=O)c2c(F)cccc2F)cn1)-c1nn(C)c(=O)o1
Show InChI InChI=1S/C21H15F2N5O4/c1-28-21(30)32-20(27-28)11-6-7-16(31-2)12(8-11)15-9-25-17(10-24-15)26-19(29)18-13(22)4-3-5-14(18)23/h3-10H,1-2H3,(H,25,26,29)
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n/an/a<100n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387273
PNG
(US10292981, Example 135 | rrr)
Show SMILES CNc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C25H21F2N3O3/c1-25(2)23(31)22(30-33-25)15-9-12-20(28-3)17(13-15)14-7-10-16(11-8-14)29-24(32)21-18(26)5-4-6-19(21)27/h4-13,28H,1-3H3,(H,29,32)
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n/an/a<100n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387263
PNG
(N-(2′- acetamido-5′-(5,5- dimethyl-4-o...)
Show SMILES CC(=O)Nc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C26H21F2N3O4/c1-14(32)29-21-12-9-16(23-24(33)26(2,3)35-31-23)13-18(21)15-7-10-17(11-8-15)30-25(34)22-19(27)5-4-6-20(22)28/h4-13H,1-3H3,(H,29,32)(H,30,34)
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n/an/a<100n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387278
PNG
(N-(2,6- Difluorophenyl)-5-(2- ethyl-5-(4-methyl-5-...)
Show SMILES CCc1ccc(cc1-c1ccc(s1)C(=O)Nc1c(F)cccc1F)-c1nn(C)c(=O)o1
Show InChI InChI=1S/C22H17F2N3O3S/c1-3-12-7-8-13(21-26-27(2)22(29)30-21)11-14(12)17-9-10-18(31-17)20(28)25-19-15(23)5-4-6-16(19)24/h4-11H,3H2,1-2H3,(H,25,28)
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n/an/a<100n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387265
PNG
(2,6- Difluoro-N-(2′- methyl-5′-(4-meth...)
Show SMILES Cc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)-c1nn(C)c(=O)o1
Show InChI InChI=1S/C23H17F2N3O3/c1-13-6-7-15(22-27-28(2)23(30)31-22)12-17(13)14-8-10-16(11-9-14)26-21(29)20-18(24)4-3-5-19(20)25/h3-12H,1-2H3,(H,26,29)
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n/an/a<100n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387261
PNG
(N-(5′- (5,5-Dimethyl-4-oxo- 4,5-dihydroisoxa...)
Show SMILES Cc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C25H20F2N2O3/c1-14-7-8-16(22-23(30)25(2,3)32-29-22)13-18(14)15-9-11-17(12-10-15)28-24(31)21-19(26)5-4-6-20(21)27/h4-13H,1-3H3,(H,28,31)
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n/an/a<100n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387280
PNG
(N-(2,6- Difluorophenyl)-5-(2- methyl-3-(4-methyl- ...)
Show SMILES Cc1c(cccc1-c1nn(C)c(=O)o1)-c1ccc(s1)C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C21H15F2N3O3S/c1-11-12(5-3-6-13(11)20-25-26(2)21(28)29-20)16-9-10-17(30-16)19(27)24-18-14(22)7-4-8-15(18)23/h3-10H,1-2H3,(H,24,27)
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n/an/a<100n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387279
PNG
(5-(2- (Difluoromethoxy)-5- (4-methyl-5-oxo-4,5- di...)
Show SMILES Cn1nc(oc1=O)-c1ccc(OC(F)F)c(c1)-c1ccc(s1)C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C21H13F4N3O4S/c1-28-21(30)32-19(27-28)10-5-6-14(31-20(24)25)11(9-10)15-7-8-16(33-15)18(29)26-17-12(22)3-2-4-13(17)23/h2-9,20H,1H3,(H,26,29)
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n/an/a<100n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387277
PNG
(N-(2,6- Difluorophenyl)-5-(5- (5,5-dimethyl-4-oxo-...)
Show SMILES COc1ccc(cc1-c1ccc(s1)C(=O)Nc1c(F)cccc1F)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C23H18F2N2O4S/c1-23(2)21(28)19(27-31-23)12-7-8-16(30-3)13(11-12)17-9-10-18(32-17)22(29)26-20-14(24)5-4-6-15(20)25/h4-11H,1-3H3,(H,26,29)
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n/an/a<100n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387268
PNG
(N-(2′- Chloro-5′-(4-methyl- 5-oxo-4,5-...)
Show SMILES Cn1nc(oc1=O)-c1ccc(Cl)c(c1)-c1ccc(NC(=O)c2c(F)cccc2F)cc1
Show InChI InChI=1S/C22H14ClF2N3O3/c1-28-22(30)31-21(27-28)13-7-10-16(23)15(11-13)12-5-8-14(9-6-12)26-20(29)19-17(24)3-2-4-18(19)25/h2-11H,1H3,(H,26,29)
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n/an/a<100n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387272
PNG
(N-(5-(5- (5,5-dimethyl-4-oxo- 4,5-dihydroisoxazol-...)
Show SMILES Cc1ccc(cc1-c1cnc(NC(=O)c2c(F)cncc2F)cn1)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C22H17F2N5O3/c1-11-4-5-12(19-20(30)22(2,3)32-29-19)6-13(11)16-9-27-17(10-26-16)28-21(31)18-14(23)7-25-8-15(18)24/h4-10H,1-3H3,(H,27,28,31)
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n/an/a<100n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387269
PNG
(2- Chloro-N-(5-(5-(5,5- dimethyl-4-oxo-4,5- dihydr...)
Show SMILES Cc1ccc(cc1-c1cnc(NC(=O)c2c(F)cccc2Cl)cn1)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C23H18ClFN4O3/c1-12-7-8-13(20-21(30)23(2,3)32-29-20)9-14(12)17-10-27-18(11-26-17)28-22(31)19-15(24)5-4-6-16(19)25/h4-11H,1-3H3,(H,27,28,31)
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n/an/a<100n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387274
PNG
(N-(2,6- Difluorophenyl)-5-(5- (5,5-dimethyl-4-oxo-...)
Show SMILES CCc1ccc(cc1-c1ccc(s1)C(=O)Nc1c(F)cccc1F)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C24H20F2N2O3S/c1-4-13-8-9-14(20-22(29)24(2,3)31-28-20)12-15(13)18-10-11-19(32-18)23(30)27-21-16(25)6-5-7-17(21)26/h5-12H,4H2,1-3H3,(H,27,30)
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n/an/a<100n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387267
PNG
(2,6- Difluoro-N-(2′- methoxy-5′-(4- me...)
Show SMILES COc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)-c1nn(C)c(=O)o1
Show InChI InChI=1S/C23H17F2N3O4/c1-28-23(30)32-22(27-28)14-8-11-19(31-2)16(12-14)13-6-9-15(10-7-13)26-21(29)20-17(24)4-3-5-18(20)25/h3-12H,1-2H3,(H,26,29)
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n/an/a<100n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387264
PNG
(N-(3′- (5,5-Dimethyl-4-oxo- 4,5-dihydroisoxa...)
Show SMILES Cc1c(cccc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C25H20F2N2O3/c1-14-17(6-4-7-18(14)22-23(30)25(2,3)32-29-22)15-10-12-16(13-11-15)28-24(31)21-19(26)8-5-9-20(21)27/h4-13H,1-3H3,(H,28,31)
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n/an/a<100n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387270
PNG
(2,6- Difluoro-N-(5-(2- methyl-5-(4- methyl-5-oxo-4...)
Show SMILES Cc1ccc(cc1-c1cnc(NC(=O)c2c(F)cccc2F)cn1)-c1nn(C)c(=O)o1
Show InChI InChI=1S/C21H15F2N5O3/c1-11-6-7-12(20-27-28(2)21(30)31-20)8-13(11)16-9-25-17(10-24-16)26-19(29)18-14(22)4-3-5-15(18)23/h3-10H,1-2H3,(H,25,26,29)
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n/an/a<100n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Nuclear factor of activated T-cells, cytoplasmic 2


(Homo sapiens (Human))
BDBM387315
PNG
(4- Methyl-N-(2′-methyl- 3′-(4-methyl-5...)
Show SMILES Cc1nnsc1C(=O)Nc1ccc(cc1)-c1cccc(-c2nn(C)c(=O)o2)c1C
Show InChI InChI=1S/C20H17N5O3S/c1-11-15(5-4-6-16(11)19-23-25(3)20(27)28-19)13-7-9-14(10-8-13)21-18(26)17-12(2)22-24-29-17/h4-10H,1-3H3,(H,21,26)
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n/an/a<500n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
HEK 293 cells were stably transfected with a NFAT-Luc reporter gene. 30,000-80,000 cells were seeded per well. Test compounds from this invention wer...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Nuclear factor of activated T-cells, cytoplasmic 2


(Homo sapiens (Human))
BDBM387273
PNG
(US10292981, Example 135 | rrr)
Show SMILES CNc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C25H21F2N3O3/c1-25(2)23(31)22(30-33-25)15-9-12-20(28-3)17(13-15)14-7-10-16(11-8-14)29-24(32)21-18(26)5-4-6-19(21)27/h4-13,28H,1-3H3,(H,29,32)
PDB

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n/an/a<500n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
HEK 293 cells were stably transfected with a NFAT-Luc reporter gene. 30,000-80,000 cells were seeded per well. Test compounds from this invention wer...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Nuclear factor of activated T-cells, cytoplasmic 2


(Homo sapiens (Human))
BDBM387280
PNG
(N-(2,6- Difluorophenyl)-5-(2- methyl-3-(4-methyl- ...)
Show SMILES Cc1c(cccc1-c1nn(C)c(=O)o1)-c1ccc(s1)C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C21H15F2N3O3S/c1-11-12(5-3-6-13(11)20-25-26(2)21(28)29-20)16-9-10-17(30-16)19(27)24-18-14(22)7-4-8-15(18)23/h3-10H,1-2H3,(H,24,27)
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n/an/a<500n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
HEK 293 cells were stably transfected with a NFAT-Luc reporter gene. 30,000-80,000 cells were seeded per well. Test compounds from this invention wer...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Nuclear factor of activated T-cells, cytoplasmic 2


(Homo sapiens (Human))
BDBM387264
PNG
(N-(3′- (5,5-Dimethyl-4-oxo- 4,5-dihydroisoxa...)
Show SMILES Cc1c(cccc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C25H20F2N2O3/c1-14-17(6-4-7-18(14)22-23(30)25(2,3)32-29-22)15-10-12-16(13-11-15)28-24(31)21-19(26)8-5-9-20(21)27/h4-13H,1-3H3,(H,28,31)
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n/an/a<500n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
HEK 293 cells were stably transfected with a NFAT-Luc reporter gene. 30,000-80,000 cells were seeded per well. Test compounds from this invention wer...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387289
PNG
(N-(5-(5- (5,5-dimethyl-4-oxo- 4,5-dihydroisoxazol-...)
Show SMILES Cc1ccc(cc1-c1cnc(NC(=O)c2cccnc2C)cn1)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C23H21N5O3/c1-13-7-8-15(20-21(29)23(3,4)31-28-20)10-17(13)18-11-26-19(12-25-18)27-22(30)16-6-5-9-24-14(16)2/h5-12H,1-4H3,(H,26,27,30)
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n/an/a 550n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387295
PNG
(3,5- Dichloro-N-(5-(5-(5,5- dimethyl-4-oxo-4,5- di...)
Show SMILES Cc1ccc(cc1-c1cnc(NC(=O)c2c(Cl)cncc2Cl)cn1)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C22H17Cl2N5O3/c1-11-4-5-12(19-20(30)22(2,3)32-29-19)6-13(11)16-9-27-17(10-26-16)28-21(31)18-14(23)7-25-8-15(18)24/h4-10H,1-3H3,(H,27,28,31)
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n/an/a 550n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387290
PNG
(N-(5- (5,5-Dimethyl-4,5- dihydroisoxazol-3- yl)-2-...)
Show SMILES Cc1ccc(cc1-c1cnc(NC(=O)c2c(F)cccc2F)cn1)C1=NOC(C)(C)C1
Show InChI InChI=1S/C23H20F2N4O2/c1-13-7-8-14(18-10-23(2,3)31-29-18)9-15(13)19-11-27-20(12-26-19)28-22(30)21-16(24)5-4-6-17(21)25/h4-9,11-12H,10H2,1-3H3,(H,27,28,30)
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n/an/a 550n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387287
PNG
(2,6- Difluoro-N-(5′-(4- methoxy-5,5- dimethy...)
Show SMILES COC1C(=NOC1(C)C)c1ccc(C)c(c1)-c1ccc(NC(=O)c2c(F)cccc2F)cc1
Show InChI InChI=1S/C26H24F2N2O3/c1-15-8-9-17(23-24(32-4)26(2,3)33-30-23)14-19(15)16-10-12-18(13-11-16)29-25(31)22-20(27)6-5-7-21(22)28/h5-14,24H,1-4H3,(H,29,31)
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n/an/a 550n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387293
PNG
(N-(5-(5- (5,5-Dimethyl-4-oxo- 4,5-dihydroisoxazol-...)
Show SMILES Cc1ccc(cc1-c1cnc(NC(=O)c2cc(F)ccc2F)cn1)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C23H18F2N4O3/c1-12-4-5-13(20-21(30)23(2,3)32-29-20)8-15(12)18-10-27-19(11-26-18)28-22(31)16-9-14(24)6-7-17(16)25/h4-11H,1-3H3,(H,27,28,31)
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n/an/a 550n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387291
PNG
(2,6- Difluoro-N-(2′- methyl-5′-(4-oxo-...)
Show SMILES Cc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)C1=NOC2(CCCCC2)C1=O
Show InChI InChI=1S/C28H24F2N2O3/c1-17-8-9-19(25-26(33)28(35-32-25)14-3-2-4-15-28)16-21(17)18-10-12-20(13-11-18)31-27(34)24-22(29)6-5-7-23(24)30/h5-13,16H,2-4,14-15H2,1H3,(H,31,34)
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n/an/a 550n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387286
PNG
(2,6- difluoro-N-(5-(5-(4- methoxy-5,5- dimethyl-4,...)
Show SMILES COC1C(=NOC1(C)C)c1ccc(C)c(c1)-c1cnc(NC(=O)c2c(F)cccc2F)cn1
Show InChI InChI=1S/C24H22F2N4O3/c1-13-8-9-14(21-22(32-4)24(2,3)33-30-21)10-15(13)18-11-28-19(12-27-18)29-23(31)20-16(25)6-5-7-17(20)26/h5-12,22H,1-4H3,(H,28,29,31)
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n/an/a 550n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387285
PNG
(N-(6-(5- (5,5-dimethyl-4-oxo- 4,5-dihydroisoxazol-...)
Show SMILES COc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cn1)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C24H19F2N3O4/c1-24(2)22(30)21(29-33-24)13-7-10-19(32-3)15(11-13)18-9-8-14(12-27-18)28-23(31)20-16(25)5-4-6-17(20)26/h4-12H,1-3H3,(H,28,31)
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n/an/a 550n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387284
PNG
(N-(2′- chloro-5′-(5,5- dimethyl-4-oxo-...)
Show SMILES CC1(C)ON=C(C1=O)c1ccc(Cl)c(c1)-c1ccc(NC(=O)c2c(F)cccc2F)cc1
Show InChI InChI=1S/C24H17ClF2N2O3/c1-24(2)22(30)21(29-32-24)14-8-11-17(25)16(12-14)13-6-9-15(10-7-13)28-23(31)20-18(26)4-3-5-19(20)27/h3-12H,1-2H3,(H,28,31)
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n/an/a 550n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387297
PNG
(US10292981, Example 121 | rrr)
Show SMILES Cc1ccc(cc1-c1cnc(cn1)C(=O)Nc1c(F)cccc1F)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C23H18F2N4O3/c1-12-7-8-13(19-21(30)23(2,3)32-29-19)9-14(12)17-10-27-18(11-26-17)22(31)28-20-15(24)5-4-6-16(20)25/h4-11H,1-3H3,(H,28,31)
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n/an/a 550n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387299
PNG
(N-(5-(5- (5,5-dimethyl-4-oxo- 4,5-dihydroisoxazol-...)
Show SMILES CC(C)Oc1ccc(cc1-c1cnc(NC(=O)c2c(F)cccc2F)cn1)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C25H22F2N4O4/c1-13(2)34-19-9-8-14(22-23(32)25(3,4)35-31-22)10-15(19)18-11-29-20(12-28-18)30-24(33)21-16(26)6-5-7-17(21)27/h5-13H,1-4H3,(H,29,30,33)
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n/an/a 550n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387283
PNG
(N-(5-(5- (5,5-dimethyl-4-oxo- 4,5-dihydroisoxazol-...)
Show SMILES CC(C)c1ccc(cc1-c1cnc(NC(=O)c2c(F)cccc2F)cn1)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C25H22F2N4O3/c1-13(2)15-9-8-14(22-23(32)25(3,4)34-31-22)10-16(15)19-11-29-20(12-28-19)30-24(33)21-17(26)6-5-7-18(21)27/h5-13H,1-4H3,(H,29,30,33)
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n/an/a 550n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387288
PNG
(N-(3′- (5,5-Dimethyl-4-oxo- 4,5-dihydroisoxa...)
Show SMILES COc1c(cccc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C25H20F2N2O4/c1-25(2)23(30)21(29-33-25)17-7-4-6-16(22(17)32-3)14-10-12-15(13-11-14)28-24(31)20-18(26)8-5-9-19(20)27/h4-13H,1-3H3,(H,28,31)
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n/an/a 550n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387296
PNG
(N-(5-(5- (5,5-dimethyl-4-oxo- 4,5-dihydroisoxazol-...)
Show SMILES Cc1ccc(cc1-c1cnc(NC(=O)c2ccncc2F)cn1)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C22H18FN5O3/c1-12-4-5-13(19-20(29)22(2,3)31-28-19)8-15(12)17-10-26-18(11-25-17)27-21(30)14-6-7-24-9-16(14)23/h4-11H,1-3H3,(H,26,27,30)
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n/an/a 550n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387307
PNG
(US10292981, Example 138 | rrr)
Show SMILES Cc1c(cccc1-c1cnc(NC(=O)C2CCc3ccccc3C2)cn1)-c1nn(C)c(=O)o1
Show InChI InChI=1S/C25H23N5O3/c1-15-19(8-5-9-20(15)24-29-30(2)25(32)33-24)21-13-27-22(14-26-21)28-23(31)18-11-10-16-6-3-4-7-17(16)12-18/h3-9,13-14,18H,10-12H2,1-2H3,(H,27,28,31)
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n/an/a 550n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387281
PNG
(N-(5-(5- (5,5-Dimethyl-4-oxo- 4,5-dihydroisoxazol-...)
Show SMILES Cc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)nc1)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C24H19F2N3O3/c1-13-7-8-14(21-22(30)24(2,3)32-29-21)11-16(13)15-9-10-19(27-12-15)28-23(31)20-17(25)5-4-6-18(20)26/h4-12H,1-3H3,(H,27,28,31)
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n/an/a 550n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387282
PNG
(N-(6-(5- (5,5-dimethyl-4-oxo- 4,5-dihydroisoxazol-...)
Show SMILES CCc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cn1)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C25H21F2N3O3/c1-4-14-8-9-15(22-23(31)25(2,3)33-30-22)12-17(14)20-11-10-16(13-28-20)29-24(32)21-18(26)6-5-7-19(21)27/h5-13H,4H2,1-3H3,(H,29,32)
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n/an/a 550n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387292
PNG
(N-(5′- (4,4-dimethyl-4,5- dihydrooxazol-2-y...)
Show SMILES Cc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)C1=NC(C)(C)CO1
Show InChI InChI=1S/C25H22F2N2O2/c1-15-7-8-17(24-29-25(2,3)14-31-24)13-19(15)16-9-11-18(12-10-16)28-23(30)22-20(26)5-4-6-21(22)27/h4-13H,14H2,1-3H3,(H,28,30)
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n/an/a 550n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387301
PNG
(N-(2′- (allyloxy)-5′-(5,5- dimethyl-4-...)
Show SMILES CC1(C)ON=C(C1=O)c1ccc(OCC=C)c(c1)-c1ccc(NC(=O)c2c(F)cccc2F)cc1
Show InChI InChI=1S/C27H22F2N2O4/c1-4-14-34-22-13-10-17(24-25(32)27(2,3)35-31-24)15-19(22)16-8-11-18(12-9-16)30-26(33)23-20(28)6-5-7-21(23)29/h4-13,15H,1,14H2,2-3H3,(H,30,33)
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n/an/a 550n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387306
PNG
(US10292981, Example 136 | rrr)
Show SMILES CN(C)c1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C26H23F2N3O3/c1-26(2)24(32)23(30-34-26)16-10-13-21(31(3)4)18(14-16)15-8-11-17(12-9-15)29-25(33)22-19(27)6-5-7-20(22)28/h5-14H,1-4H3,(H,29,33)
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n/an/a 550n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387294
PNG
(US10292981, Example 78 | rrr)
Show SMILES Cc1ccc(cc1-c1cnc(NC(=O)c2ccccc2Cl)cn1)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C23H19ClN4O3/c1-13-8-9-14(20-21(29)23(2,3)31-28-20)10-16(13)18-11-26-19(12-25-18)27-22(30)15-6-4-5-7-17(15)24/h4-12H,1-3H3,(H,26,27,30)
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n/an/a 550n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387312
PNG
(2,6- Difluoro-N-(5′-(5-(2- hydroxyethyl)-5- ...)
Show SMILES Cc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)C1=NOC(CO)(CCO)C1
Show InChI InChI=1S/C26H24F2N2O4/c1-16-5-6-18(23-14-26(15-32,11-12-31)34-30-23)13-20(16)17-7-9-19(10-8-17)29-25(33)24-21(27)3-2-4-22(24)28/h2-10,13,31-32H,11-12,14-15H2,1H3,(H,29,33)
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US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Store-operated calcium entry-associated regulatory factor


(Homo sapiens (Human))
BDBM387313
PNG
(N-(5′- (5,5-dimethyl-4-oxo- 4,5-dihydroisox...)
Show SMILES COc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C25H20F2N2O4/c1-25(2)23(30)22(29-33-25)15-9-12-20(32-3)17(13-15)14-7-10-16(11-8-14)28-24(31)21-18(26)5-4-6-19(21)27/h4-13H,1-3H3,(H,28,31)
PDB

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US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat E6.1 cells were seeded at a density of 1-2105 cells per well in calcium-4 dye prepared in calcium free HBSS (Sigma, USA). Test compounds from...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Store-operated calcium entry-associated regulatory factor


(Homo sapiens (Human))
BDBM387277
PNG
(N-(2,6- Difluorophenyl)-5-(5- (5,5-dimethyl-4-oxo-...)
Show SMILES COc1ccc(cc1-c1ccc(s1)C(=O)Nc1c(F)cccc1F)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C23H18F2N2O4S/c1-23(2)21(28)19(27-31-23)12-7-8-16(30-3)13(11-12)17-9-10-18(32-17)22(29)26-20-14(24)5-4-6-15(20)25/h4-11H,1-3H3,(H,26,29)
PDB

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US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat E6.1 cells were seeded at a density of 1-2105 cells per well in calcium-4 dye prepared in calcium free HBSS (Sigma, USA). Test compounds from...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Store-operated calcium entry-associated regulatory factor


(Homo sapiens (Human))
BDBM387314
PNG
(2- Chloro-6-fluoro-N- (2′-methoxy-5′-(...)
Show SMILES COc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2Cl)cc1)-c1nn(C)c(=O)o1
Show InChI InChI=1S/C23H17ClFN3O4/c1-28-23(30)32-22(27-28)14-8-11-19(31-2)16(12-14)13-6-9-15(10-7-13)26-21(29)20-17(24)4-3-5-18(20)25/h3-12H,1-2H3,(H,26,29)
PDB

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US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat E6.1 cells were seeded at a density of 1-2105 cells per well in calcium-4 dye prepared in calcium free HBSS (Sigma, USA). Test compounds from...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387310
PNG
(N-(5-(5- (5,5-Dimethyl-4-oxo- 4,5-dihydroisoxazol-...)
Show SMILES Cc1ccc(cc1-c1cnc(NC(=O)c2ccc(F)cc2)cn1)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C23H19FN4O3/c1-13-4-5-15(20-21(29)23(2,3)31-28-20)10-17(13)18-11-26-19(12-25-18)27-22(30)14-6-8-16(24)9-7-14/h4-12H,1-3H3,(H,26,27,30)
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US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Store-operated calcium entry-associated regulatory factor


(Homo sapiens (Human))
BDBM387280
PNG
(N-(2,6- Difluorophenyl)-5-(2- methyl-3-(4-methyl- ...)
Show SMILES Cc1c(cccc1-c1nn(C)c(=O)o1)-c1ccc(s1)C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C21H15F2N3O3S/c1-11-12(5-3-6-13(11)20-25-26(2)21(28)29-20)16-9-10-17(30-16)19(27)24-18-14(22)7-4-8-15(18)23/h3-10H,1-2H3,(H,24,27)
PDB

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US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat E6.1 cells were seeded at a density of 1-2105 cells per well in calcium-4 dye prepared in calcium free HBSS (Sigma, USA). Test compounds from...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387308
PNG
(N-(2′- (tert-butyl)-5′-(5,5- dimethyl-...)
Show SMILES CC(C)(C)c1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C28H26F2N2O3/c1-27(2,3)20-14-11-17(24-25(33)28(4,5)35-32-24)15-19(20)16-9-12-18(13-10-16)31-26(34)23-21(29)7-6-8-22(23)30/h6-15H,1-5H3,(H,31,34)
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US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))
BDBM387309
PNG
(N-(5-(5- (5,5-dimethyl-4-oxo- 4,5-dihydroisoxazol...)
Show SMILES COc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)nc1)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C24H19F2N3O4/c1-24(2)22(30)21(29-33-24)13-7-9-18(32-3)15(11-13)14-8-10-19(27-12-14)28-23(31)20-16(25)5-4-6-17(20)26/h4-12H,1-3H3,(H,27,28,31)
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US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
Store-operated calcium entry-associated regulatory factor


(Homo sapiens (Human))
BDBM387273
PNG
(US10292981, Example 135 | rrr)
Show SMILES CNc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)C1=NOC(C)(C)C1=O
Show InChI InChI=1S/C25H21F2N3O3/c1-25(2)23(31)22(30-33-25)15-9-12-20(28-3)17(13-15)14-7-10-16(11-8-14)29-24(32)21-18(26)5-4-6-19(21)27/h4-13,28H,1-3H3,(H,29,32)
PDB

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US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



LUPIN LIMITED

US Patent


Assay Description
Jurkat E6.1 cells were seeded at a density of 1-2105 cells per well in calcium-4 dye prepared in calcium free HBSS (Sigma, USA). Test compounds from...


US Patent US10292981 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%