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Patent code US10294217

Compile Data Set for Download or QSAR
Found 35 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387795
PNG
(Cis-N-(3-Fluoropiperidin-4-yl)-1-(2-fluoropyridin-...)
Show SMILES FC1CNCCC1NC(=O)c1cn(Cc2ccnc(F)c2)c2c(F)ccc(F)c12
Show InChI InChI=1S/C20H18F4N4O/c21-13-1-2-14(22)19-18(13)12(20(29)27-16-4-5-25-8-15(16)23)10-28(19)9-11-3-6-26-17(24)7-11/h1-3,6-7,10,15-16,25H,4-5,8-9H2,(H,27,29)
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n/an/an/an/a 1.44E+3n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387804
PNG
(US10294217, Example 31 | US10294217, Example 32)
Show SMILES FC1CNCCC1NC(=O)c1cn(Cc2ccc(F)cc2)c2c(F)ccc(F)c12
Show InChI InChI=1S/C21H19F4N3O/c22-13-3-1-12(2-4-13)10-28-11-14(19-15(23)5-6-16(24)20(19)28)21(29)27-18-7-8-26-9-17(18)25/h1-6,11,17-18,26H,7-10H2,(H,27,29)
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n/an/an/an/a 1.61E+3n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387810
PNG
(US10294217, Example 37 | US10294217, Example 38)
Show SMILES COc1ccc(Cn2cc(C(=O)NC3CCNCC3F)c3c(F)cccc23)cc1
Show InChI InChI=1S/C22H23F2N3O2/c1-29-15-7-5-14(6-8-15)12-27-13-16(21-17(23)3-2-4-20(21)27)22(28)26-19-9-10-25-11-18(19)24/h2-8,13,18-19,25H,9-12H2,1H3,(H,26,28)
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n/an/an/an/a 1.99E+3n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387810
PNG
(US10294217, Example 37 | US10294217, Example 38)
Show SMILES COc1ccc(Cn2cc(C(=O)NC3CCNCC3F)c3c(F)cccc23)cc1
Show InChI InChI=1S/C22H23F2N3O2/c1-29-15-7-5-14(6-8-15)12-27-13-16(21-17(23)3-2-4-20(21)27)22(28)26-19-9-10-25-11-18(19)24/h2-8,13,18-19,25H,9-12H2,1H3,(H,26,28)
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n/an/an/an/a 1.45E+3n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387814
PNG
(US10294217, Example 45)
Show SMILES FC1CNCCC1NC(=O)c1cn(Cc2ccc3ncsc3c2)c2cccc(F)c12
Show InChI InChI=1S/C22H20F2N4OS/c23-15-2-1-3-19-21(15)14(22(29)27-17-6-7-25-9-16(17)24)11-28(19)10-13-4-5-18-20(8-13)30-12-26-18/h1-5,8,11-12,16-17,25H,6-7,9-10H2,(H,27,29)
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n/an/an/an/a 1.16E+3n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387785
PNG
(US10294217, Example 6)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1cn(Cc2ccnc(Cl)c2)c2c(F)ccc(F)c12
Show InChI InChI=1S/C21H20ClF2N3O2/c22-18-9-12(7-8-25-18)10-27-11-13(19-14(23)5-6-15(24)20(19)27)21(29)26-16-3-1-2-4-17(16)28/h5-9,11,16-17,28H,1-4,10H2,(H,26,29)/t16-,17-/m0/s1
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n/an/an/an/a 122n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387801
PNG
(US10294217, Example 28 | US10294217, Example 29)
Show SMILES FC1CNCCC1NC(=O)c1cn(Cc2ccnc(Cl)c2)c2c(F)ccc(F)c12
Show InChI InChI=1S/C20H18ClF3N4O/c21-17-7-11(3-6-26-17)9-28-10-12(18-13(22)1-2-14(23)19(18)28)20(29)27-16-4-5-25-8-15(16)24/h1-3,6-7,10,15-16,25H,4-5,8-9H2,(H,27,29)
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n/an/an/an/a 1.57E+3n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387781
PNG
(N-[(1S,2S)-2-Hydroxycyclohexyl]-1-(1-methyl-1H-pyr...)
Show SMILES Cn1cc(Cn2cc(C(=O)N[C@H]3CCCC[C@@H]3O)c3c(F)cccc23)cn1
Show InChI InChI=1S/C20H23FN4O2/c1-24-10-13(9-22-24)11-25-12-14(19-15(21)5-4-7-17(19)25)20(27)23-16-6-2-3-8-18(16)26/h4-5,7,9-10,12,16,18,26H,2-3,6,8,11H2,1H3,(H,23,27)/t16-,18-/m0/s1
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n/an/an/an/a 1.26E+3n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387783
PNG
(US10294217, Example 3)
Show SMILES Cn1cc(Cn2cc(C(=O)N[C@@H]3CCCC[C@H]3O)c3c(F)cccc23)cn1
Show InChI InChI=1S/C20H23FN4O2/c1-24-10-13(9-22-24)11-25-12-14(19-15(21)5-4-7-17(19)25)20(27)23-16-6-2-3-8-18(16)26/h4-5,7,9-10,12,16,18,26H,2-3,6,8,11H2,1H3,(H,23,27)/t16-,18-/m1/s1
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n/an/an/an/a 370n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387790
PNG
(US10294217, Example 11)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1cn(Cc2cc(F)ncc2F)c2cccc(F)c12
Show InChI InChI=1S/C21H20F3N3O2/c22-14-4-3-6-17-20(14)13(21(29)26-16-5-1-2-7-18(16)28)11-27(17)10-12-8-19(24)25-9-15(12)23/h3-4,6,8-9,11,16,18,28H,1-2,5,7,10H2,(H,26,29)/t16-,18-/m0/s1
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n/an/an/an/a 1.53E+3n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387795
PNG
(Cis-N-(3-Fluoropiperidin-4-yl)-1-(2-fluoropyridin-...)
Show SMILES FC1CNCCC1NC(=O)c1cn(Cc2ccnc(F)c2)c2c(F)ccc(F)c12
Show InChI InChI=1S/C20H18F4N4O/c21-13-1-2-14(22)19-18(13)12(20(29)27-16-4-5-25-8-15(16)23)10-28(19)9-11-3-6-26-17(24)7-11/h1-3,6-7,10,15-16,25H,4-5,8-9H2,(H,27,29)
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n/an/an/an/a 1.07E+3n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387801
PNG
(US10294217, Example 28 | US10294217, Example 29)
Show SMILES FC1CNCCC1NC(=O)c1cn(Cc2ccnc(Cl)c2)c2c(F)ccc(F)c12
Show InChI InChI=1S/C20H18ClF3N4O/c21-17-7-11(3-6-26-17)9-28-10-12(18-13(22)1-2-14(23)19(18)28)20(29)27-16-4-5-25-8-15(16)24/h1-3,6-7,10,15-16,25H,4-5,8-9H2,(H,27,29)
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n/an/an/an/a 2.92E+3n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387783
PNG
(US10294217, Example 3)
Show SMILES Cn1cc(Cn2cc(C(=O)N[C@@H]3CCCC[C@H]3O)c3c(F)cccc23)cn1
Show InChI InChI=1S/C20H23FN4O2/c1-24-10-13(9-22-24)11-25-12-14(19-15(21)5-4-7-17(19)25)20(27)23-16-6-2-3-8-18(16)26/h4-5,7,9-10,12,16,18,26H,2-3,6,8,11H2,1H3,(H,23,27)/t16-,18-/m1/s1
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n/an/an/an/a 1.64E+3n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387791
PNG
(US10294217, Example 12)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1cn(Cc2cc(F)ncc2F)c2c(F)ccc(F)c12
Show InChI InChI=1S/C21H19F4N3O2/c22-13-5-6-14(23)20-19(13)12(21(30)27-16-3-1-2-4-17(16)29)10-28(20)9-11-7-18(25)26-8-15(11)24/h5-8,10,16-17,29H,1-4,9H2,(H,27,30)/t16-,17-/m0/s1
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n/an/an/an/a 432n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387792
PNG
(US10294217, Example 13)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1cn(Cc2ccnc(F)c2F)c2cccc(F)c12
Show InChI InChI=1S/C21H20F3N3O2/c22-14-4-3-6-16-18(14)13(21(29)26-15-5-1-2-7-17(15)28)11-27(16)10-12-8-9-25-20(24)19(12)23/h3-4,6,8-9,11,15,17,28H,1-2,5,7,10H2,(H,26,29)/t15-,17-/m0/s1
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n/an/an/an/a 1.38E+3n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387793
PNG
(US10294217, Example 18)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1cn(Cc2ccc3ncsc3c2)c2cccc(F)c12
Show InChI InChI=1S/C23H22FN3O2S/c24-16-4-3-6-19-22(16)15(23(29)26-17-5-1-2-7-20(17)28)12-27(19)11-14-8-9-18-21(10-14)30-13-25-18/h3-4,6,8-10,12-13,17,20,28H,1-2,5,7,11H2,(H,26,29)/t17-,20-/m0/s1
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n/an/an/an/a 160n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387784
PNG
(US10294217, Example 4)
Show SMILES Cn1nc(Cn2cc(C(=O)N[C@H]3CCCC[C@@H]3O)c3c(F)cccc23)c2ccccc12
Show InChI InChI=1S/C24H25FN4O2/c1-28-20-10-4-2-7-15(20)19(27-28)14-29-13-16(23-17(25)8-6-11-21(23)29)24(31)26-18-9-3-5-12-22(18)30/h2,4,6-8,10-11,13,18,22,30H,3,5,9,12,14H2,1H3,(H,26,31)/t18-,22-/m0/s1
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n/an/an/an/a 1.49E+3n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387787
PNG
(US10294217, Example 8)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1cn(Cc2ccnc(F)c2)c2c(F)ccc(F)c12
Show InChI InChI=1S/C21H20F3N3O2/c22-14-5-6-15(23)20-19(14)13(21(29)26-16-3-1-2-4-17(16)28)11-27(20)10-12-7-8-25-18(24)9-12/h5-9,11,16-17,28H,1-4,10H2,(H,26,29)/t16-,17-/m0/s1
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n/an/an/an/a 192n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387789
PNG
(US10294217, Example 10)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1cn(Cc2ccncc2F)c2c(F)ccc(F)c12
Show InChI InChI=1S/C21H20F3N3O2/c22-14-5-6-15(23)20-19(14)13(21(29)26-17-3-1-2-4-18(17)28)11-27(20)10-12-7-8-25-9-16(12)24/h5-9,11,17-18,28H,1-4,10H2,(H,26,29)/t17-,18-/m0/s1
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n/an/an/an/a 940n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387800
PNG
(US10294217, Example 27)
Show SMILES FC1CNCCC1NC(=O)c1cn(Cc2ccnc(Cl)c2)c2cccc(F)c12
Show InChI InChI=1S/C20H19ClF2N4O/c21-18-8-12(4-7-25-18)10-27-11-13(19-14(22)2-1-3-17(19)27)20(28)26-16-5-6-24-9-15(16)23/h1-4,7-8,11,15-16,24H,5-6,9-10H2,(H,26,28)
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n/an/an/an/a 1.69E+3n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387803
PNG
(US10294217, Example 30)
Show SMILES FC1CNCCC1NC(=O)c1cn(Cc2ccc(F)cc2)c2cccc(F)c12
Show InChI InChI=1S/C21H20F3N3O/c22-14-6-4-13(5-7-14)11-27-12-15(20-16(23)2-1-3-19(20)27)21(28)26-18-8-9-25-10-17(18)24/h1-7,12,17-18,25H,8-11H2,(H,26,28)
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US Patent
n/an/an/an/a 1.08E+3n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387806
PNG
(US10294217, Example 33)
Show SMILES FC1CNCCC1NC(=O)c1cn(Cc2ccccc2F)c2cccc(F)c12
Show InChI InChI=1S/C21H20F3N3O/c22-15-5-2-1-4-13(15)11-27-12-14(20-16(23)6-3-7-19(20)27)21(28)26-18-8-9-25-10-17(18)24/h1-7,12,17-18,25H,8-11H2,(H,26,28)
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n/an/an/an/a 1.37E+3n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387808
PNG
(US10294217, Example 35 | US10294217, Example 36)
Show SMILES COc1cccc(Cn2cc(C(=O)NC3CCNCC3F)c3c(F)cccc23)c1
Show InChI InChI=1S/C22H23F2N3O2/c1-29-15-5-2-4-14(10-15)12-27-13-16(21-17(23)6-3-7-20(21)27)22(28)26-19-8-9-25-11-18(19)24/h2-7,10,13,18-19,25H,8-9,11-12H2,1H3,(H,26,28)
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n/an/an/an/a 1.35E+3n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387782
PNG
(N-[(1S,2S)-2-Hydroxycyclohexyl]-1-(2-chloropyridin...)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1cn(Cc2ccnc(Cl)c2)c2cccc(F)c12
Show InChI InChI=1S/C21H21ClFN3O2/c22-19-10-13(8-9-24-19)11-26-12-14(20-15(23)4-3-6-17(20)26)21(28)25-16-5-1-2-7-18(16)27/h3-4,6,8-10,12,16,18,27H,1-2,5,7,11H2,(H,25,28)/t16-,18-/m0/s1
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n/an/an/an/a 681n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387786
PNG
(US10294217, Example 7)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1cn(Cc2ccnc(F)c2)c2cccc(F)c12
Show InChI InChI=1S/C21H21F2N3O2/c22-15-4-3-6-17-20(15)14(21(28)25-16-5-1-2-7-18(16)27)12-26(17)11-13-8-9-24-19(23)10-13/h3-4,6,8-10,12,16,18,27H,1-2,5,7,11H2,(H,25,28)/t16-,18-/m0/s1
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n/an/an/an/a 1.36E+3n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387788
PNG
(US10294217, Example 9)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1cn(Cc2ccncc2F)c2cccc(F)c12
Show InChI InChI=1S/C21H21F2N3O2/c22-15-4-3-6-18-20(15)14(21(28)25-17-5-1-2-7-19(17)27)12-26(18)11-13-8-9-24-10-16(13)23/h3-4,6,8-10,12,17,19,27H,1-2,5,7,11H2,(H,25,28)/t17-,19-/m0/s1
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n/an/an/an/a 1.42E+3n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387794
PNG
(US10294217, Example 19)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1cn(Cc2cnn(CCF)c2)c2cccc(F)c12
Show InChI InChI=1S/C21H24F2N4O2/c22-8-9-27-12-14(10-24-27)11-26-13-15(20-16(23)4-3-6-18(20)26)21(29)25-17-5-1-2-7-19(17)28/h3-4,6,10,12-13,17,19,28H,1-2,5,7-9,11H2,(H,25,29)/t17-,19-/m0/s1
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n/an/an/an/a 744n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387804
PNG
(US10294217, Example 31 | US10294217, Example 32)
Show SMILES FC1CNCCC1NC(=O)c1cn(Cc2ccc(F)cc2)c2c(F)ccc(F)c12
Show InChI InChI=1S/C21H19F4N3O/c22-13-3-1-12(2-4-13)10-28-11-14(19-15(23)5-6-16(24)20(19)28)21(29)27-18-7-8-26-9-17(18)25/h1-6,11,17-18,26H,7-10H2,(H,27,29)
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n/an/an/an/a 1.59E+3n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387807
PNG
(US10294217, Example 34)
Show SMILES FC1CNCCC1NC(=O)c1cn(Cc2ccc(Cl)cc2)c2cccc(F)c12
Show InChI InChI=1S/C21H20ClF2N3O/c22-14-6-4-13(5-7-14)11-27-12-15(20-16(23)2-1-3-19(20)27)21(28)26-18-8-9-25-10-17(18)24/h1-7,12,17-18,25H,8-11H2,(H,26,28)
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n/an/an/an/a 1.39E+3n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387808
PNG
(US10294217, Example 35 | US10294217, Example 36)
Show SMILES COc1cccc(Cn2cc(C(=O)NC3CCNCC3F)c3c(F)cccc23)c1
Show InChI InChI=1S/C22H23F2N3O2/c1-29-15-5-2-4-14(10-15)12-27-13-16(21-17(23)6-3-7-20(21)27)22(28)26-19-8-9-25-11-18(19)24/h2-7,10,13,18-19,25H,8-9,11-12H2,1H3,(H,26,28)
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n/an/an/an/a 1.48E+3n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387812
PNG
(US10294217, Example 39)
Show SMILES COc1ccc(Cn2cc(C(=O)NC3CCNCC3F)c3c(F)ccc(F)c23)cc1
Show InChI InChI=1S/C22H22F3N3O2/c1-30-14-4-2-13(3-5-14)11-28-12-15(20-16(23)6-7-17(24)21(20)28)22(29)27-19-8-9-26-10-18(19)25/h2-7,12,18-19,26H,8-11H2,1H3,(H,27,29)
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n/an/an/an/a 1.49E+3n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387813
PNG
(US10294217, Example 44)
Show SMILES FC1CNCCC1NC(=O)c1cn(Cc2ccnc(F)c2)c2cccc(F)c12
Show InChI InChI=1S/C20H19F3N4O/c21-14-2-1-3-17-19(14)13(20(28)26-16-5-6-24-9-15(16)22)11-27(17)10-12-4-7-25-18(23)8-12/h1-4,7-8,11,15-16,24H,5-6,9-10H2,(H,26,28)
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n/an/an/an/a 1.31E+3n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387795
PNG
(Cis-N-(3-Fluoropiperidin-4-yl)-1-(2-fluoropyridin-...)
Show SMILES FC1CNCCC1NC(=O)c1cn(Cc2ccnc(F)c2)c2c(F)ccc(F)c12
Show InChI InChI=1S/C20H18F4N4O/c21-13-1-2-14(22)19-18(13)12(20(29)27-16-4-5-25-8-15(16)23)10-28(19)9-11-3-6-26-17(24)7-11/h1-3,6-7,10,15-16,25H,4-5,8-9H2,(H,27,29)
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n/an/an/an/a 1.50E+3n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387795
PNG
(Cis-N-(3-Fluoropiperidin-4-yl)-1-(2-fluoropyridin-...)
Show SMILES FC1CNCCC1NC(=O)c1cn(Cc2ccnc(F)c2)c2c(F)ccc(F)c12
Show InChI InChI=1S/C20H18F4N4O/c21-13-1-2-14(22)19-18(13)12(20(29)27-16-4-5-25-8-15(16)23)10-28(19)9-11-3-6-26-17(24)7-11/h1-3,6-7,10,15-16,25H,4-5,8-9H2,(H,27,29)
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n/an/an/an/a 1.39E+3n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM387799
PNG
(US10294217, Example 26)
Show SMILES FC1CNCCC1NC(=O)c1cn(Cc2ccncc2F)c2c(F)ccc(F)c12
Show InChI InChI=1S/C20H18F4N4O/c21-13-1-2-14(22)19-18(13)12(20(29)27-17-4-6-26-8-16(17)24)10-28(19)9-11-3-5-25-7-15(11)23/h1-3,5,7,10,16-17,26H,4,6,8-9H2,(H,27,29)
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n/an/an/an/a 1.11E+3n/an/an/an/a



Suven Life Sciences Limited

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...

US Patent US10294217 (2019)


BindingDB Entry DOI: 10.7270/Q2W37ZM1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%