BindingDB logo
myBDB logout

Patent code US10294221

Compile Data Set for Download or QSAR
Found 63 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278409
PNG
((2S)-2-[3-(Difluoromethoxy)phenyl]-2-methoxy-N-[5-...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC(F)F)c1
Show InChI InChI=1/C20H21F2N7O3S/c1-31-16(12-4-2-5-14(10-12)32-18(21)22)17(30)25-20-28-27-19(33-20)24-13-7-9-29(11-13)15-6-3-8-23-26-15/h2-6,8,10,13,16,18H,7,9,11H2,1H3,(H,24,27)(H,25,28,30)/t13-,16+/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 14.8n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278401
PNG
((2R)-2-Methoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccccc1
Show InChI InChI=1/C19H21N7O2S/c1-28-16(13-6-3-2-4-7-13)17(27)22-19-25-24-18(29-19)21-14-9-11-26(12-14)15-8-5-10-20-23-15/h2-8,10,14,16H,9,11-12H2,1H3,(H,21,24)(H,22,25,27)/t14-,16-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 15.3n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278401
PNG
((2R)-2-Methoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccccc1
Show InChI InChI=1/C19H21N7O2S/c1-28-16(13-6-3-2-4-7-13)17(27)22-19-25-24-18(29-19)21-14-9-11-26(12-14)15-8-5-10-20-23-15/h2-8,10,14,16H,9,11-12H2,1H3,(H,21,24)(H,22,25,27)/t14-,16-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 16.2n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278413
PNG
((2S)-2-Methoxy-N-[5-[[(3R)-1-pyridazin-3-ylpyrroli...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1/C20H20F3N7O3S/c1-32-16(12-4-2-5-14(10-12)33-20(21,22)23)17(31)26-19-29-28-18(34-19)25-13-7-9-30(11-13)15-6-3-8-24-27-15/h2-6,8,10,13,16H,7,9,11H2,1H3,(H,25,28)(H,26,29,31)/t13-,16+/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 18.6n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM387867
PNG
(US10294221, Example 30(b))
Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC)c1
Show InChI InChI=1S/C21H25N7O3S/c1-3-31-18(14-6-4-7-16(12-14)30-2)19(29)24-21-27-26-20(32-21)23-15-9-11-28(13-15)17-8-5-10-22-25-17/h4-8,10,12,15,18H,3,9,11,13H2,1-2H3,(H,23,26)(H,24,27,29)/t15-,18+/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/a 21n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278400
PNG
((2S)-2-Methoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccccc1
Show InChI InChI=1/C19H21N7O2S/c1-28-16(13-6-3-2-4-7-13)17(27)22-19-25-24-18(29-19)21-14-9-11-26(12-14)15-8-5-10-20-23-15/h2-8,10,14,16H,9,11-12H2,1H3,(H,21,24)(H,22,25,27)/t14-,16+/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 21.3n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278405
PNG
((2S)-2-Methoxy-2-(3-methoxyphenyl)-N-[5-[[(3R)-1-p...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC)c1
Show InChI InChI=1/C20H23N7O3S/c1-29-15-6-3-5-13(11-15)17(30-2)18(28)23-20-26-25-19(31-20)22-14-8-10-27(12-14)16-7-4-9-21-24-16/h3-7,9,11,14,17H,8,10,12H2,1-2H3,(H,22,25)(H,23,26,28)/t14-,17+/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 21.5n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM387835
PNG
((2S)-2-(4-Fluorophenyl)-2-methoxy-N-[5-[[(3R)-1-py...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)cc1
Show InChI InChI=1S/C19H20FN7O2S/c1-29-16(12-4-6-13(20)7-5-12)17(28)23-19-26-25-18(30-19)22-14-8-10-27(11-14)15-3-2-9-21-24-15/h2-7,9,14,16H,8,10-11H2,1H3,(H,22,25)(H,23,26,28)/t14-,16+/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/a 22n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278422
PNG
((2S)-2-(4-Fluoro-3-methoxy-phenyl)-2-methoxy-N-[5-...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)c(OC)c1
Show InChI InChI=1/C20H22FN7O3S/c1-30-15-10-12(5-6-14(15)21)17(31-2)18(29)24-20-27-26-19(32-20)23-13-7-9-28(11-13)16-4-3-8-22-25-16/h3-6,8,10,13,17H,7,9,11H2,1-2H3,(H,23,26)(H,24,27,29)/t13-,17+/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 25.5n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM387837
PNG
((2S)-2-Ethoxy-2-(4-fluorophenyl)-N-[5-[[(3R)-1-pyr...)
Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)cc1
Show InChI InChI=1S/C20H22FN7O2S/c1-2-30-17(13-5-7-14(21)8-6-13)18(29)24-20-27-26-19(31-20)23-15-9-11-28(12-15)16-4-3-10-22-25-16/h3-8,10,15,17H,2,9,11-12H2,1H3,(H,23,26)(H,24,27,29)/t15-,17+/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/a 27n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278410
PNG
((2R)-2-[3-(Difluoromethoxy)phenyl]-2-methoxy-N-[5-...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC(F)F)c1
Show InChI InChI=1/C20H21F2N7O3S/c1-31-16(12-4-2-5-14(10-12)32-18(21)22)17(30)25-20-28-27-19(33-20)24-13-7-9-29(11-13)15-6-3-8-23-26-15/h2-6,8,10,13,16,18H,7,9,11H2,1H3,(H,24,27)(H,25,28,30)/t13-,16-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 27.1n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278415
PNG
((2S)-2-Ethoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-y...)
Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccccc1
Show InChI InChI=1/C20H23N7O2S/c1-2-29-17(14-7-4-3-5-8-14)18(28)23-20-26-25-19(30-20)22-15-10-12-27(13-15)16-9-6-11-21-24-16/h3-9,11,15,17H,2,10,12-13H2,1H3,(H,22,25)(H,23,26,28)/t15-,17+/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 27.6n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM387853
PNG
(US10294221, Example 23(a))
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cncnn2)s1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C19H20F2N8O3S/c1-31-15(11-3-2-4-13(7-11)32-17(20)21)16(30)25-19-28-27-18(33-19)24-12-5-6-29(9-12)14-8-22-10-23-26-14/h2-4,7-8,10,12,15,17H,5-6,9H2,1H3,(H,24,27)(H,25,28,30)/t12-,15-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/a 27.6n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM50172181
PNG
(CHEMBL3810394 | US10040788, Example 3 | US10294221...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cncnn2)s1)c1ccccc1
Show InChI InChI=1/C18H20N8O2S/c1-28-15(12-5-3-2-4-6-12)16(27)22-18-25-24-17(29-18)21-13-7-8-26(10-13)14-9-19-11-20-23-14/h2-6,9,11,13,15H,7-8,10H2,1H3,(H,21,24)(H,22,25,27)/t13-,15+/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 29n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278411
PNG
((2S)-2-Methoxy-N-[5-[[(3R)-1-(1,2,4-triazin-3-yl)p...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1/C19H19F3N8O3S/c1-32-14(11-3-2-4-13(9-11)33-19(20,21)22)15(31)26-18-29-28-17(34-18)25-12-5-8-30(10-12)16-23-6-7-24-27-16/h2-4,6-7,9,12,14H,5,8,10H2,1H3,(H,25,28)(H,26,29,31)/t12-,14+/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 30.6n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM50172239
PNG
(CHEMBL3809014 | US10040788, Example 11 | US1029422...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(OC)cc1
Show InChI InChI=1/C20H23N7O3S/c1-29-15-7-5-13(6-8-15)17(30-2)18(28)23-20-26-25-19(31-20)22-14-9-11-27(12-14)16-4-3-10-21-24-16/h3-8,10,14,17H,9,11-12H2,1-2H3,(H,22,25)(H,23,26,28)/t14-,17+/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 31n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278414
PNG
((2R)-2-Methoxy-N-[5-[[(3R)-1-pyridazin-3-ylpyrroli...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1/C20H20F3N7O3S/c1-32-16(12-4-2-5-14(10-12)33-20(21,22)23)17(31)26-19-29-28-18(34-19)25-13-7-9-30(11-13)15-6-3-8-24-27-15/h2-6,8,10,13,16H,7,9,11H2,1H3,(H,25,28)(H,26,29,31)/t13-,16-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 32.9n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278445
PNG
(US10040788, Example 28(a) | US10294221, Example 28...)
Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(OC)cc1
Show InChI InChI=1/C21H25N7O3S/c1-3-31-18(14-6-8-16(30-2)9-7-14)19(29)24-21-27-26-20(32-21)23-15-10-12-28(13-15)17-5-4-11-22-25-17/h4-9,11,15,18H,3,10,12-13H2,1-2H3,(H,23,26)(H,24,27,29)/t15-,18-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 34.1n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278439
PNG
(US10040788, Example 25(a) | US10294221, Example 25...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(OC)c(OC)c1
Show InChI InChI=1/C21H25N7O4S/c1-30-15-7-6-13(11-16(15)31-2)18(32-3)19(29)24-21-27-26-20(33-21)23-14-8-10-28(12-14)17-5-4-9-22-25-17/h4-7,9,11,14,18H,8,10,12H2,1-3H3,(H,23,26)(H,24,27,29)/t14-,18-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 35.4n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278403
PNG
((2S)-2-Methoxy-2-(3-methoxyphenyl)-N-[5-[[(3R)-1-(...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(OC)c1
Show InChI InChI=1/C19H22N8O3S/c1-29-14-5-3-4-12(10-14)15(30-2)16(28)23-19-26-25-18(31-19)22-13-6-9-27(11-13)17-20-7-8-21-24-17/h3-5,7-8,10,13,15H,6,9,11H2,1-2H3,(H,22,25)(H,23,26,28)/t13-,15+/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 35.5n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278434
PNG
(US10040788, Example 22(a) | US10294221, Example 22...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cncnn2)s1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1/C19H19F3N8O3S/c1-32-15(11-3-2-4-13(7-11)33-19(20,21)22)16(31)26-18-29-28-17(34-18)25-12-5-6-30(9-12)14-8-23-10-24-27-14/h2-4,7-8,10,12,15H,5-6,9H2,1H3,(H,25,28)(H,26,29,31)/t12-,15+/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 43.4n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278432
PNG
(US10040788, Example 21(a) | US10294221, Example 21...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cncnn2)s1)c1cccc(OC)c1
Show InChI InChI=1/C19H22N8O3S/c1-29-14-5-3-4-12(8-14)16(30-2)17(28)23-19-26-25-18(31-19)22-13-6-7-27(10-13)15-9-20-11-21-24-15/h3-5,8-9,11,13,16H,6-7,10H2,1-2H3,(H,22,25)(H,23,26,28)/t13-,16+/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 46.9n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278451
PNG
(US10040788, Example 31(a) | US10294221, Example 31...)
Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)c(OC)c1
Show InChI InChI=1/C21H24FN7O3S/c1-3-32-18(13-6-7-15(22)16(11-13)31-2)19(30)25-21-28-27-20(33-21)24-14-8-10-29(12-14)17-5-4-9-23-26-17/h4-7,9,11,14,18H,3,8,10,12H2,1-2H3,(H,24,27)(H,25,28,30)/t14-,18-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50.2n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278455
PNG
(US10040788, Example 33(a) | US10294221, Example 33...)
Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccc(F)c(OC)c1
Show InChI InChI=1/C20H23FN8O3S/c1-3-32-16(12-4-5-14(21)15(10-12)31-2)17(30)25-20-28-27-19(33-20)24-13-6-9-29(11-13)18-22-7-8-23-26-18/h4-5,7-8,10,13,16H,3,6,9,11H2,1-2H3,(H,24,27)(H,25,28,30)/t13-,16-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50.2n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278443
PNG
(US10040788, Example 27(a) | US10294221, Example 27...)
Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(OC)c1
Show InChI InChI=1/C20H24N8O3S/c1-3-31-16(13-5-4-6-15(11-13)30-2)17(29)24-20-27-26-19(32-20)23-14-7-10-28(12-14)18-21-8-9-22-25-18/h4-6,8-9,11,14,16H,3,7,10,12H2,1-2H3,(H,23,26)(H,24,27,29)/t14-,16-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50.8n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM50172138
PNG
(CHEMBL3808443 | US10040788, Example 1(a) | US10294...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccccc1
Show InChI InChI=1/C18H20N8O2S/c1-28-14(12-5-3-2-4-6-12)15(27)22-18-25-24-17(29-18)21-13-7-10-26(11-13)16-19-8-9-20-23-16/h2-6,8-9,13-14H,7,10-11H2,1H3,(H,21,24)(H,22,25,27)/t13-,14+/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
US Patent
n/an/a 62.8n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM387871
PNG
(US10294221, Example 32(b))
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccc(F)c(OC)c1
Show InChI InChI=1S/C19H21FN8O3S/c1-30-14-9-11(3-4-13(14)20)15(31-2)16(29)24-19-27-26-18(32-19)23-12-5-8-28(10-12)17-21-6-7-22-25-17/h3-4,6-7,9,12,15H,5,8,10H2,1-2H3,(H,23,26)(H,24,27,29)/t12-,15+/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/a 70.7n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM50172241
PNG
(CHEMBL3810168 | US10294221, Example 22(a))
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cncnn2)s1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1/C19H19F3N8O3S/c1-32-15(11-3-2-4-13(7-11)33-19(20,21)22)16(31)26-18-29-28-17(34-18)25-12-5-6-30(9-12)14-8-23-10-24-27-14/h2-4,7-8,10,12,15H,5-6,9H2,1H3,(H,25,28)(H,26,29,31)/t12-,15-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 72.9n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278438
PNG
((2S)-2-methoxy-2-(4- methoxyphenyl)-N-[5-[[(3R)- 1...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccc(OC)cc1
Show InChI InChI=1/C19H22N8O3S/c1-29-14-5-3-12(4-6-14)15(30-2)16(28)23-19-26-25-18(31-19)22-13-7-10-27(11-13)17-20-8-9-21-24-17/h3-6,8-9,13,15H,7,10-11H2,1-2H3,(H,22,25)(H,23,26,28)/t13-,15+/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 74.7n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM387863
PNG
(US10294221, Example 28(b))
Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(OC)cc1
Show InChI InChI=1S/C21H25N7O3S/c1-3-31-18(14-6-8-16(30-2)9-7-14)19(29)24-21-27-26-20(32-21)23-15-10-12-28(13-15)17-5-4-11-22-25-17/h4-9,11,15,18H,3,10,12-13H2,1-2H3,(H,23,26)(H,24,27,29)/t15-,18+/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/a 84.8n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278407
PNG
((2S)-2-[3-(Difluoromethoxy)phenyl]-2-methoxy-N-[5-...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(OC(F)F)c1
Show InChI InChI=1/C19H20F2N8O3S/c1-31-14(11-3-2-4-13(9-11)32-16(20)21)15(30)25-19-28-27-18(33-19)24-12-5-8-29(10-12)17-22-6-7-23-26-17/h2-4,6-7,9,12,14,16H,5,8,10H2,1H3,(H,24,27)(H,25,28,30)/t12-,14+/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 85.1n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278408
PNG
((2R)-2-[3-(Difluoromethoxy)phenyl]-2-methoxy-N-[5-...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(OC(F)F)c1
Show InChI InChI=1/C19H20F2N8O3S/c1-31-14(11-3-2-4-13(9-11)32-16(20)21)15(30)25-19-28-27-18(33-19)24-12-5-8-29(10-12)17-22-6-7-23-26-17/h2-4,6-7,9,12,14,16H,5,8,10H2,1H3,(H,24,27)(H,25,28,30)/t12-,14-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 85.1n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM387869
PNG
(US10294221, Example 31(b))
Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)c(OC)c1
Show InChI InChI=1S/C21H24FN7O3S/c1-3-32-18(13-6-7-15(22)16(11-13)31-2)19(30)25-21-28-27-20(33-21)24-14-8-10-29(12-14)17-5-4-9-23-26-17/h4-7,9,11,14,18H,3,8,10,12H2,1-2H3,(H,24,27)(H,25,28,30)/t14-,18+/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/a 86.2n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM387859
PNG
(US10294221, Example 26(b))
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C20H24N8O4S/c1-30-14-5-4-12(10-15(14)31-2)16(32-3)17(29)24-20-27-26-19(33-20)23-13-6-9-28(11-13)18-21-7-8-22-25-18/h4-5,7-8,10,13,16H,6,9,11H2,1-3H3,(H,23,26)(H,24,27,29)/t13-,16+/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/a 87.7n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278406
PNG
((2R)-2-Methoxy-2-(3-methoxyphenyl)-N-[5-[[(3R)-1-p...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC)c1
Show InChI InChI=1/C20H23N7O3S/c1-29-15-6-3-5-13(11-15)17(30-2)18(28)23-20-26-25-19(31-20)22-14-8-10-27(12-14)16-7-4-9-21-24-16/h3-7,9,11,14,17H,8,10,12H2,1-2H3,(H,22,25)(H,23,26,28)/t14-,17-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 87.9n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278457
PNG
(US10040788, Example 34(a) | US10294221, Example 34...)
Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccccc1
Show InChI InChI=1/C19H22N8O2S/c1-2-29-15(13-6-4-3-5-7-13)16(28)23-19-26-25-18(30-19)22-14-8-11-27(12-14)17-20-9-10-21-24-17/h3-7,9-10,14-15H,2,8,11-12H2,1H3,(H,22,25)(H,23,26,28)/t14-,15-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 88.1n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278425
PNG
(US10040788, Example 17(b) | US10294221, Example 17...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccc(F)cc1
Show InChI InChI=1/C18H19FN8O2S/c1-29-14(11-2-4-12(19)5-3-11)15(28)23-18-26-25-17(30-18)22-13-6-9-27(10-13)16-20-7-8-21-24-16/h2-5,7-8,13-14H,6,9-10H2,1H3,(H,22,25)(H,23,26,28)/t13-,14-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 92.6n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278449
PNG
(US10040788, Example 30(a) | US10294221, Example 30...)
Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC)c1
Show InChI InChI=1/C21H25N7O3S/c1-3-31-18(14-6-4-7-16(12-14)30-2)19(29)24-21-27-26-20(32-21)23-15-9-11-28(13-15)17-8-5-10-22-25-17/h4-8,10,12,15,18H,3,9,11,13H2,1-2H3,(H,23,26)(H,24,27,29)/t15-,18-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 92.8n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278418
PNG
((2S)-2-(4-Fluorophenyl)-2-methoxy-N-[5-[[(3R)-1-py...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)cc1
Show InChI InChI=1/C19H20FN7O2S/c1-29-16(12-4-6-13(20)7-5-12)17(28)23-19-26-25-18(30-19)22-14-8-10-27(11-14)15-3-2-9-21-24-15/h2-7,9,14,16H,8,10-11H2,1H3,(H,22,25)(H,23,26,28)/t14-,16-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 102n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278400
PNG
((2S)-2-Methoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccccc1
Show InChI InChI=1/C19H21N7O2S/c1-28-16(13-6-3-2-4-7-13)17(27)22-19-25-24-18(29-19)21-14-9-11-26(12-14)15-8-5-10-20-23-15/h2-8,10,14,16H,9,11-12H2,1H3,(H,21,24)(H,22,25,27)/t14-,16+/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 107n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278447
PNG
(US10040788, Example 29(a) | US10294221, Example 29...)
Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccc(OC)cc1
Show InChI InChI=1/C20H24N8O3S/c1-3-31-16(13-4-6-15(30-2)7-5-13)17(29)24-20-27-26-19(32-20)23-14-8-11-28(12-14)18-21-9-10-22-25-18/h4-7,9-10,14,16H,3,8,11-12H2,1-2H3,(H,23,26)(H,24,27,29)/t14-,16-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 108n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278416
PNG
((2R)-2-Ethoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-y...)
Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccccc1
Show InChI InChI=1/C20H23N7O2S/c1-2-29-17(14-7-4-3-5-8-14)18(28)23-20-26-25-19(30-20)22-15-10-12-27(13-15)16-9-6-11-21-24-16/h3-9,11,15,17H,2,10,12-13H2,1H3,(H,22,25)(H,23,26,28)/t15-,17-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 110n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278400
PNG
((2S)-2-Methoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccccc1
Show InChI InChI=1/C19H21N7O2S/c1-28-16(13-6-3-2-4-7-13)17(27)22-19-25-24-18(29-19)21-14-9-11-26(12-14)15-8-5-10-20-23-15/h2-8,10,14,16H,9,11-12H2,1H3,(H,21,24)(H,22,25,27)/t14-,16+/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 119n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM387857
PNG
(US10294221, Example 25(b))
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C21H25N7O4S/c1-30-15-7-6-13(11-16(15)31-2)18(32-3)19(29)24-21-27-26-20(33-21)23-14-8-10-28(12-14)17-5-4-9-22-25-17/h4-7,9,11,14,18H,8,10,12H2,1-3H3,(H,23,26)(H,24,27,29)/t14-,18+/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/a 135n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278401
PNG
((2R)-2-Methoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccccc1
Show InChI InChI=1/C19H21N7O2S/c1-28-16(13-6-3-2-4-7-13)17(27)22-19-25-24-18(29-19)21-14-9-11-26(12-14)15-8-5-10-20-23-15/h2-8,10,14,16H,9,11-12H2,1H3,(H,21,24)(H,22,25,27)/t14-,16-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 147n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278460
PNG
(US10040788, Example 35(b) | US10294221, Example 35...)
Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccc(F)cc1
Show InChI InChI=1/C19H21FN8O2S/c1-2-30-15(12-3-5-13(20)6-4-12)16(29)24-19-27-26-18(31-19)23-14-7-10-28(11-14)17-21-8-9-22-25-17/h3-6,8-9,14-15H,2,7,10-11H2,1H3,(H,23,26)(H,24,27,29)/t14-,15+/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 155n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278436
PNG
(US10040788, Example 23(a) | US10294221, Example 23...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cncnn2)s1)c1cccc(OC(F)F)c1
Show InChI InChI=1/C19H20F2N8O3S/c1-31-15(11-3-2-4-13(7-11)32-17(20)21)16(30)25-19-28-27-18(33-19)24-12-5-6-29(9-12)14-8-22-10-23-26-14/h2-4,7-8,10,12,15,17H,5-6,9H2,1H3,(H,24,27)(H,25,28,30)/t12-,15+/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 162n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM387849
PNG
(US10294221, Example 21(a))
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cncnn2)s1)c1cccc(OC)c1
Show InChI InChI=1S/C19H22N8O3S/c1-29-14-5-3-4-12(8-14)16(30-2)17(28)23-19-26-25-18(31-19)22-13-6-7-27(10-13)15-9-20-11-21-24-15/h3-5,8-9,11,13,16H,6-7,10H2,1-2H3,(H,22,25)(H,23,26,28)/t13-,16-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/a 162n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278423
PNG
((2R)-2-(4-Fluoro-3-methoxy-phenyl)-2-methoxy-N-[5-...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)c(OC)c1
Show InChI InChI=1/C20H22FN7O3S/c1-30-15-10-12(5-6-14(15)21)17(31-2)18(29)24-20-27-26-19(32-20)23-13-7-9-28(11-13)16-4-3-8-22-25-16/h3-6,8,10,13,17H,7,9,11H2,1-2H3,(H,23,26)(H,24,27,29)/t13-,17-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 168n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278420
PNG
((2S)-2-Ethoxy-2-(4-fluorophenyl)-N-[5-[[(3R)-1-pyr...)
Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)cc1
Show InChI InChI=1/C20H22FN7O2S/c1-2-30-17(13-5-7-14(21)8-6-13)18(29)24-20-27-26-19(31-20)23-15-9-11-28(12-15)16-4-3-10-22-25-16/h3-8,10,15,17H,2,9,11-12H2,1H3,(H,23,26)(H,24,27,29)/t15-,17-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 170n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278412
PNG
((2R)-2-Methoxy-N-[5-[[(3R)-1-(1,2,4-triazin-3-yl)p...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1/C19H19F3N8O3S/c1-32-14(11-3-2-4-13(9-11)33-19(20,21)22)15(31)26-18-29-28-17(34-18)25-12-5-8-30(10-12)16-23-6-7-24-27-16/h2-4,6-7,9,12,14H,5,8,10H2,1H3,(H,25,28)(H,26,29,31)/t12-,14-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 221n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278407
PNG
((2S)-2-[3-(Difluoromethoxy)phenyl]-2-methoxy-N-[5-...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(OC(F)F)c1
Show InChI InChI=1/C19H20F2N8O3S/c1-31-14(11-3-2-4-13(9-11)32-16(20)21)15(30)25-19-28-27-18(33-19)24-12-5-8-29(10-12)17-22-6-7-23-26-17/h2-4,6-7,9,12,14,16H,5,8,10H2,1H3,(H,24,27)(H,25,28,30)/t12-,14+/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 519n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278408
PNG
((2R)-2-[3-(Difluoromethoxy)phenyl]-2-methoxy-N-[5-...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(OC(F)F)c1
Show InChI InChI=1/C19H20F2N8O3S/c1-31-14(11-3-2-4-13(9-11)32-16(20)21)15(30)25-19-28-27-18(33-19)24-12-5-8-29(10-12)17-22-6-7-23-26-17/h2-4,6-7,9,12,14,16H,5,8,10H2,1H3,(H,24,27)(H,25,28,30)/t12-,14-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 519n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM387861
PNG
(US10294221, Example 27(b))
Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(OC)c1
Show InChI InChI=1S/C20H24N8O3S/c1-3-31-16(13-5-4-6-15(11-13)30-2)17(29)24-20-27-26-19(32-20)23-14-7-10-28(12-14)18-21-8-9-22-25-18/h4-6,8-9,11,14,16H,3,7,10,12H2,1-2H3,(H,23,26)(H,24,27,29)/t14-,16+/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
UniChem
US Patent
n/an/a 844n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278404
PNG
((2R)-2-Methoxy-2-(3-methoxyphenyl)-N-[5-[[(3R)-1-(...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(OC)c1
Show InChI InChI=1/C19H22N8O3S/c1-29-14-5-3-4-12(10-14)15(30-2)16(28)23-19-26-25-18(31-19)22-13-6-9-27(11-13)17-20-7-8-21-24-17/h3-5,7-8,10,13,15H,6,9,11H2,1-2H3,(H,22,25)(H,23,26,28)/t13-,15-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 908n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278448
PNG
(US10040788, Example 29(b) | US10294221, Example 29...)
Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccc(OC)cc1
Show InChI InChI=1/C20H24N8O3S/c1-3-31-16(13-4-6-15(30-2)7-5-13)17(29)24-20-27-26-19(32-20)23-14-8-11-28(12-14)18-21-9-10-22-25-18/h4-7,9-10,14,16H,3,8,11-12H2,1-2H3,(H,23,26)(H,24,27,29)/t14-,16+/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.37E+3n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278458
PNG
(US10040788, Example 34(b) | US10294221, Example 34...)
Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccccc1
Show InChI InChI=1/C19H22N8O2S/c1-2-29-15(13-6-4-3-5-7-13)16(28)23-19-26-25-18(30-19)22-14-8-11-27(12-14)17-20-9-10-21-24-17/h3-7,9-10,14-15H,2,8,11-12H2,1H3,(H,22,25)(H,23,26,28)/t14-,15+/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.48E+3n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278399
PNG
((2R)-2-Methoxy-2-phenyl-N-[5-[[(3R)-1-(1,2,4-triaz...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccccc1
Show InChI InChI=1/C18H20N8O2S/c1-28-14(12-5-3-2-4-6-12)15(27)22-18-25-24-17(29-18)21-13-7-10-26(11-13)16-19-8-9-20-23-16/h2-6,8-9,13-14H,7,10-11H2,1H3,(H,21,24)(H,22,25,27)/t13-,14-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.70E+3n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278459
PNG
(US10040788, Example 35(a) | US10294221, Example 35...)
Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccc(F)cc1
Show InChI InChI=1/C19H21FN8O2S/c1-2-30-15(12-3-5-13(20)6-4-12)16(29)24-19-27-26-18(31-19)23-14-7-10-28(11-14)17-21-8-9-22-25-17/h3-6,8-9,14-15H,2,7,10-11H2,1H3,(H,23,26)(H,24,27,29)/t14-,15-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.95E+3n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278456
PNG
(US10040788, Example 33(b) | US10294221, Example 33...)
Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccc(F)c(OC)c1
Show InChI InChI=1/C20H23FN8O3S/c1-3-32-16(12-4-5-14(21)15(10-12)31-2)17(30)25-20-28-27-19(33-20)24-13-6-9-29(11-13)18-22-7-8-23-26-18/h4-5,7-8,10,13,16H,3,6,9,11H2,1-2H3,(H,24,27)(H,25,28,30)/t13-,16+/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.97E+3n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM50172240
PNG
(CHEMBL3808882 | US10040788, Example 17(a) | US1029...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccc(F)cc1
Show InChI InChI=1/C18H19FN8O2S/c1-29-14(11-2-4-12(19)5-3-11)15(28)23-18-26-25-17(30-18)22-13-6-9-27(10-13)16-20-7-8-21-24-16/h2-5,7-8,13-14H,6,9-10H2,1H3,(H,22,25)(H,23,26,28)/t13-,14+/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
US Patent
n/an/a 2.19E+3n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278441
PNG
(US10040788, Example 26(a) | US10294221, Example 26...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccc(OC)c(OC)c1
Show InChI InChI=1/C20H24N8O4S/c1-30-14-5-4-12(10-15(14)31-2)16(32-3)17(29)24-20-27-26-19(33-20)23-13-6-9-28(11-13)18-21-7-8-22-25-18/h4-5,7-8,10,13,16H,6,9,11H2,1-3H3,(H,23,26)(H,24,27,29)/t13-,16-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.27E+3n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM278453
PNG
(US10040788, Example 32(a) | US10294221, Example 32...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1ccc(F)c(OC)c1
Show InChI InChI=1/C19H21FN8O3S/c1-30-14-9-11(3-4-13(14)20)15(31-2)16(29)24-19-27-26-18(32-19)23-12-5-8-28(10-12)17-21-6-7-22-25-17/h3-4,6-7,9,12,15H,5,8,10H2,1-2H3,(H,23,26)(H,24,27,29)/t12-,15-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.46E+3n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10294221 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%