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Patent code US10294230

Compile Data Set for Download or QSAR
Found 48 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM388296
PNG
(US10294230, Compound E1-2.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@@H](CNc3cncc4nncn34)C(F)(F)C2)cc1
Show InChI InChI=1S/C20H22F2N6O2/c1-14-2-4-15(5-3-14)11-30-19(29)27-7-6-16(20(21,22)12-27)8-24-17-9-23-10-18-26-25-13-28(17)18/h2-5,9-10,13,16,24H,6-8,11-12H2,1H3/t16-/m0/s1
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n/an/a 10.4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM388296
PNG
(US10294230, Compound E1-2.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@@H](CNc3cncc4nncn34)C(F)(F)C2)cc1
Show InChI InChI=1S/C20H22F2N6O2/c1-14-2-4-15(5-3-14)11-30-19(29)27-7-6-16(20(21,22)12-27)8-24-17-9-23-10-18-26-25-13-28(17)18/h2-5,9-10,13,16,24H,6-8,11-12H2,1H3/t16-/m0/s1
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n/an/a 10.4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM388296
PNG
(US10294230, Compound E1-2.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@@H](CNc3cncc4nncn34)C(F)(F)C2)cc1
Show InChI InChI=1S/C20H22F2N6O2/c1-14-2-4-15(5-3-14)11-30-19(29)27-7-6-16(20(21,22)12-27)8-24-17-9-23-10-18-26-25-13-28(17)18/h2-5,9-10,13,16,24H,6-8,11-12H2,1H3/t16-/m0/s1
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n/an/a 10.4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM388302
PNG
(US10294230, Compound E1-21.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@H](CNc3cnccn3)C(F)(F)C2)cc1
Show InChI InChI=1S/C19H22F2N4O2/c1-14-2-4-15(5-3-14)12-27-18(26)25-9-6-16(19(20,21)13-25)10-24-17-11-22-7-8-23-17/h2-5,7-8,11,16H,6,9-10,12-13H2,1H3,(H,23,24)/t16-/m1/s1
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n/an/a 14.4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM388302
PNG
(US10294230, Compound E1-21.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@H](CNc3cnccn3)C(F)(F)C2)cc1
Show InChI InChI=1S/C19H22F2N4O2/c1-14-2-4-15(5-3-14)12-27-18(26)25-9-6-16(19(20,21)13-25)10-24-17-11-22-7-8-23-17/h2-5,7-8,11,16H,6,9-10,12-13H2,1H3,(H,23,24)/t16-/m1/s1
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n/an/a 14.4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM388302
PNG
(US10294230, Compound E1-21.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@H](CNc3cnccn3)C(F)(F)C2)cc1
Show InChI InChI=1S/C19H22F2N4O2/c1-14-2-4-15(5-3-14)12-27-18(26)25-9-6-16(19(20,21)13-25)10-24-17-11-22-7-8-23-17/h2-5,7-8,11,16H,6,9-10,12-13H2,1H3,(H,23,24)/t16-/m1/s1
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n/an/a 14.4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM388299
PNG
(US10294230, Compound E1-1.3)
Show SMILES FC1(F)CN(CC[C@@H]1CNc1nccn2cnnc12)C(=O)OCc1ccc(Cl)cc1
Show InChI InChI=1S/C19H19ClF2N6O2/c20-15-3-1-13(2-4-15)10-30-18(29)27-7-5-14(19(21,22)11-27)9-24-16-17-26-25-12-28(17)8-6-23-16/h1-4,6,8,12,14H,5,7,9-11H2,(H,23,24)/t14-/m1/s1
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n/an/a 14.8n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM388299
PNG
(US10294230, Compound E1-1.3)
Show SMILES FC1(F)CN(CC[C@@H]1CNc1nccn2cnnc12)C(=O)OCc1ccc(Cl)cc1
Show InChI InChI=1S/C19H19ClF2N6O2/c20-15-3-1-13(2-4-15)10-30-18(29)27-7-5-14(19(21,22)11-27)9-24-16-17-26-25-12-28(17)8-6-23-16/h1-4,6,8,12,14H,5,7,9-11H2,(H,23,24)/t14-/m1/s1
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n/an/a 14.8n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM388299
PNG
(US10294230, Compound E1-1.3)
Show SMILES FC1(F)CN(CC[C@@H]1CNc1nccn2cnnc12)C(=O)OCc1ccc(Cl)cc1
Show InChI InChI=1S/C19H19ClF2N6O2/c20-15-3-1-13(2-4-15)10-30-18(29)27-7-5-14(19(21,22)11-27)9-24-16-17-26-25-12-28(17)8-6-23-16/h1-4,6,8,12,14H,5,7,9-11H2,(H,23,24)/t14-/m1/s1
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n/an/a 14.8n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM388298
PNG
(US10294230, Compound E1-8.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@@H](CNc3ncc4cn[nH]c4n3)C(F)(F)C2)cc1
Show InChI InChI=1/C20H22F2N6O2/c1-13-2-4-14(5-3-13)11-30-19(29)28-7-6-16(20(21,22)12-28)10-24-18-23-8-15-9-25-27-17(15)26-18/h2-5,8-9,16H,6-7,10-12H2,1H3,(H2,23,24,25,26,27)/t16-/s2
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n/an/a 17n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM388298
PNG
(US10294230, Compound E1-8.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@@H](CNc3ncc4cn[nH]c4n3)C(F)(F)C2)cc1
Show InChI InChI=1/C20H22F2N6O2/c1-13-2-4-14(5-3-13)11-30-19(29)28-7-6-16(20(21,22)12-28)10-24-18-23-8-15-9-25-27-17(15)26-18/h2-5,8-9,16H,6-7,10-12H2,1H3,(H2,23,24,25,26,27)/t16-/s2
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n/an/a 17n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM388298
PNG
(US10294230, Compound E1-8.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@@H](CNc3ncc4cn[nH]c4n3)C(F)(F)C2)cc1
Show InChI InChI=1/C20H22F2N6O2/c1-13-2-4-14(5-3-13)11-30-19(29)28-7-6-16(20(21,22)12-28)10-24-18-23-8-15-9-25-27-17(15)26-18/h2-5,8-9,16H,6-7,10-12H2,1H3,(H2,23,24,25,26,27)/t16-/s2
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n/an/a 17n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM388300
PNG
(US10294230, Compound E1-1.4)
Show SMILES Fc1ccc(COC(=O)N2CC[C@H](CNc3nccn4cnnc34)C(F)(F)C2)cc1
Show InChI InChI=1S/C19H19F3N6O2/c20-15-3-1-13(2-4-15)10-30-18(29)27-7-5-14(19(21,22)11-27)9-24-16-17-26-25-12-28(17)8-6-23-16/h1-4,6,8,12,14H,5,7,9-11H2,(H,23,24)/t14-/m1/s1
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n/an/a 20.5n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM388300
PNG
(US10294230, Compound E1-1.4)
Show SMILES Fc1ccc(COC(=O)N2CC[C@H](CNc3nccn4cnnc34)C(F)(F)C2)cc1
Show InChI InChI=1S/C19H19F3N6O2/c20-15-3-1-13(2-4-15)10-30-18(29)27-7-5-14(19(21,22)11-27)9-24-16-17-26-25-12-28(17)8-6-23-16/h1-4,6,8,12,14H,5,7,9-11H2,(H,23,24)/t14-/m1/s1
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n/an/a 20.5n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM388300
PNG
(US10294230, Compound E1-1.4)
Show SMILES Fc1ccc(COC(=O)N2CC[C@H](CNc3nccn4cnnc34)C(F)(F)C2)cc1
Show InChI InChI=1S/C19H19F3N6O2/c20-15-3-1-13(2-4-15)10-30-18(29)27-7-5-14(19(21,22)11-27)9-24-16-17-26-25-12-28(17)8-6-23-16/h1-4,6,8,12,14H,5,7,9-11H2,(H,23,24)/t14-/m1/s1
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n/an/a 20.5n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM388294
PNG
(US10294230, Compound E1-1.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@H](CNc3nccn4cnnc34)C(F)(F)C2)cc1
Show InChI InChI=1S/C20H22F2N6O2/c1-14-2-4-15(5-3-14)11-30-19(29)27-8-6-16(20(21,22)12-27)10-24-17-18-26-25-13-28(18)9-7-23-17/h2-5,7,9,13,16H,6,8,10-12H2,1H3,(H,23,24)/t16-/m1/s1
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n/an/a 21n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM388294
PNG
(US10294230, Compound E1-1.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@H](CNc3nccn4cnnc34)C(F)(F)C2)cc1
Show InChI InChI=1S/C20H22F2N6O2/c1-14-2-4-15(5-3-14)11-30-19(29)27-8-6-16(20(21,22)12-27)10-24-17-18-26-25-13-28(18)9-7-23-17/h2-5,7,9,13,16H,6,8,10-12H2,1H3,(H,23,24)/t16-/m1/s1
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n/an/a 21n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM388294
PNG
(US10294230, Compound E1-1.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@H](CNc3nccn4cnnc34)C(F)(F)C2)cc1
Show InChI InChI=1S/C20H22F2N6O2/c1-14-2-4-15(5-3-14)11-30-19(29)27-8-6-16(20(21,22)12-27)10-24-17-18-26-25-13-28(18)9-7-23-17/h2-5,7,9,13,16H,6,8,10-12H2,1H3,(H,23,24)/t16-/m1/s1
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n/an/a 21n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM280739
PNG
(US10030026, Compound LX-1 | US10221182, Compound L...)
Show SMILES FC(F)(F)c1ccc(cc1)C(F)(F)CN1CCC(CC1)Nc1ncnc2[nH]ncc12
Show InChI InChI=1S/C19H19F5N6/c20-18(21,12-1-3-13(4-2-12)19(22,23)24)10-30-7-5-14(6-8-30)28-16-15-9-27-29-17(15)26-11-25-16/h1-4,9,11,14H,5-8,10H2,(H2,25,26,27,28,29)
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n/an/a 24n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM280739
PNG
(US10030026, Compound LX-1 | US10221182, Compound L...)
Show SMILES FC(F)(F)c1ccc(cc1)C(F)(F)CN1CCC(CC1)Nc1ncnc2[nH]ncc12
Show InChI InChI=1S/C19H19F5N6/c20-18(21,12-1-3-13(4-2-12)19(22,23)24)10-30-7-5-14(6-8-30)28-16-15-9-27-29-17(15)26-11-25-16/h1-4,9,11,14H,5-8,10H2,(H2,25,26,27,28,29)
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Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM388303
PNG
(US10294230, Compound E1-21.26)
Show SMILES Cc1ccc(COC(=O)N2CC[C@H](CNc3cnc(C)cn3)C(F)(F)C2)cc1
Show InChI InChI=1S/C20H24F2N4O2/c1-14-3-5-16(6-4-14)12-28-19(27)26-8-7-17(20(21,22)13-26)10-25-18-11-23-15(2)9-24-18/h3-6,9,11,17H,7-8,10,12-13H2,1-2H3,(H,24,25)/t17-/m1/s1
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n/an/a 38.7n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM388303
PNG
(US10294230, Compound E1-21.26)
Show SMILES Cc1ccc(COC(=O)N2CC[C@H](CNc3cnc(C)cn3)C(F)(F)C2)cc1
Show InChI InChI=1S/C20H24F2N4O2/c1-14-3-5-16(6-4-14)12-28-19(27)26-8-7-17(20(21,22)13-26)10-25-18-11-23-15(2)9-24-18/h3-6,9,11,17H,7-8,10,12-13H2,1-2H3,(H,24,25)/t17-/m1/s1
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n/an/a 38.7n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM388303
PNG
(US10294230, Compound E1-21.26)
Show SMILES Cc1ccc(COC(=O)N2CC[C@H](CNc3cnc(C)cn3)C(F)(F)C2)cc1
Show InChI InChI=1S/C20H24F2N4O2/c1-14-3-5-16(6-4-14)12-28-19(27)26-8-7-17(20(21,22)13-26)10-25-18-11-23-15(2)9-24-18/h3-6,9,11,17H,7-8,10,12-13H2,1-2H3,(H,24,25)/t17-/m1/s1
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n/an/a 38.7n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM388301
PNG
(US10294230, Compound E1-22.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@H](CNc3ncccn3)C(F)(F)C2)cc1
Show InChI InChI=1S/C19H22F2N4O2/c1-14-3-5-15(6-4-14)12-27-18(26)25-10-7-16(19(20,21)13-25)11-24-17-22-8-2-9-23-17/h2-6,8-9,16H,7,10-13H2,1H3,(H,22,23,24)/t16-/m1/s1
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n/an/a 42.4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM388301
PNG
(US10294230, Compound E1-22.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@H](CNc3ncccn3)C(F)(F)C2)cc1
Show InChI InChI=1S/C19H22F2N4O2/c1-14-3-5-15(6-4-14)12-27-18(26)25-10-7-16(19(20,21)13-25)11-24-17-22-8-2-9-23-17/h2-6,8-9,16H,7,10-13H2,1H3,(H,22,23,24)/t16-/m1/s1
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n/an/a 42.4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM388301
PNG
(US10294230, Compound E1-22.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@H](CNc3ncccn3)C(F)(F)C2)cc1
Show InChI InChI=1S/C19H22F2N4O2/c1-14-3-5-15(6-4-14)12-27-18(26)25-10-7-16(19(20,21)13-25)11-24-17-22-8-2-9-23-17/h2-6,8-9,16H,7,10-13H2,1H3,(H,22,23,24)/t16-/m1/s1
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n/an/a 42.4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM388297
PNG
(US10294230, Compound E1-9.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@@H](CNc3nc4ccccn4n3)C(F)(F)C2)cc1
Show InChI InChI=1S/C21H23F2N5O2/c1-15-5-7-16(8-6-15)13-30-20(29)27-11-9-17(21(22,23)14-27)12-24-19-25-18-4-2-3-10-28(18)26-19/h2-8,10,17H,9,11-14H2,1H3,(H,24,26)/t17-/m0/s1
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n/an/a 48.2n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM388297
PNG
(US10294230, Compound E1-9.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@@H](CNc3nc4ccccn4n3)C(F)(F)C2)cc1
Show InChI InChI=1S/C21H23F2N5O2/c1-15-5-7-16(8-6-15)13-30-20(29)27-11-9-17(21(22,23)14-27)12-24-19-25-18-4-2-3-10-28(18)26-19/h2-8,10,17H,9,11-14H2,1H3,(H,24,26)/t17-/m0/s1
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n/an/a 48.2n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM388297
PNG
(US10294230, Compound E1-9.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@@H](CNc3nc4ccccn4n3)C(F)(F)C2)cc1
Show InChI InChI=1S/C21H23F2N5O2/c1-15-5-7-16(8-6-15)13-30-20(29)27-11-9-17(21(22,23)14-27)12-24-19-25-18-4-2-3-10-28(18)26-19/h2-8,10,17H,9,11-14H2,1H3,(H,24,26)/t17-/m0/s1
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n/an/a 48.2n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM388295
PNG
(US10294230, Compound E2-1.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@@H](CNc3nccn4cnnc34)C(F)(F)C2)cc1
Show InChI InChI=1S/C20H22F2N6O2/c1-14-2-4-15(5-3-14)11-30-19(29)27-8-6-16(20(21,22)12-27)10-24-17-18-26-25-13-28(18)9-7-23-17/h2-5,7,9,13,16H,6,8,10-12H2,1H3,(H,23,24)/t16-/m0/s1
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n/an/a 156n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM388295
PNG
(US10294230, Compound E2-1.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@@H](CNc3nccn4cnnc34)C(F)(F)C2)cc1
Show InChI InChI=1S/C20H22F2N6O2/c1-14-2-4-15(5-3-14)11-30-19(29)27-8-6-16(20(21,22)12-27)10-24-17-18-26-25-13-28(18)9-7-23-17/h2-5,7,9,13,16H,6,8,10-12H2,1H3,(H,23,24)/t16-/m0/s1
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n/an/a 156n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM388295
PNG
(US10294230, Compound E2-1.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@@H](CNc3nccn4cnnc34)C(F)(F)C2)cc1
Show InChI InChI=1S/C20H22F2N6O2/c1-14-2-4-15(5-3-14)11-30-19(29)27-8-6-16(20(21,22)12-27)10-24-17-18-26-25-13-28(18)9-7-23-17/h2-5,7,9,13,16H,6,8,10-12H2,1H3,(H,23,24)/t16-/m0/s1
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n/an/a 156n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Cytochrome P450 2D6


(Homo sapiens (Human))
BDBM280739
PNG
(US10030026, Compound LX-1 | US10221182, Compound L...)
Show SMILES FC(F)(F)c1ccc(cc1)C(F)(F)CN1CCC(CC1)Nc1ncnc2[nH]ncc12
Show InChI InChI=1S/C19H19F5N6/c20-18(21,12-1-3-13(4-2-12)19(22,23)24)10-30-7-5-14(6-8-30)28-16-15-9-27-29-17(15)26-11-25-16/h1-4,9,11,14H,5-8,10H2,(H2,25,26,27,28,29)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
Inhibitory activities of test compounds on 5 major isoforms of CYP P450 were evaluated by using pooled human liver microsome (HLM, purchased from BD ...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM280739
PNG
(US10030026, Compound LX-1 | US10221182, Compound L...)
Show SMILES FC(F)(F)c1ccc(cc1)C(F)(F)CN1CCC(CC1)Nc1ncnc2[nH]ncc12
Show InChI InChI=1S/C19H19F5N6/c20-18(21,12-1-3-13(4-2-12)19(22,23)24)10-30-7-5-14(6-8-30)28-16-15-9-27-29-17(15)26-11-25-16/h1-4,9,11,14H,5-8,10H2,(H2,25,26,27,28,29)
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n/an/a 4.50E+3n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
The assay was performed on hERG channel stably expressed in HEK293 cells. The cells were cultured at 37 C. in a humidified CO2 incubator in the grow...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Cytochrome P450 2D6


(Homo sapiens (Human))
BDBM388298
PNG
(US10294230, Compound E1-8.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@@H](CNc3ncc4cn[nH]c4n3)C(F)(F)C2)cc1
Show InChI InChI=1/C20H22F2N6O2/c1-13-2-4-14(5-3-13)11-30-19(29)28-7-6-16(20(21,22)12-28)10-24-18-23-8-15-9-25-27-17(15)26-18/h2-5,8-9,16H,6-7,10-12H2,1H3,(H2,23,24,25,26,27)/t16-/s2
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n/an/a 5.90E+3n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
Inhibitory activities of test compounds on 5 major isoforms of CYP P450 were evaluated by using pooled human liver microsome (HLM, purchased from BD ...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM388298
PNG
(US10294230, Compound E1-8.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@@H](CNc3ncc4cn[nH]c4n3)C(F)(F)C2)cc1
Show InChI InChI=1/C20H22F2N6O2/c1-13-2-4-14(5-3-13)11-30-19(29)28-7-6-16(20(21,22)12-28)10-24-18-23-8-15-9-25-27-17(15)26-18/h2-5,8-9,16H,6-7,10-12H2,1H3,(H2,23,24,25,26,27)/t16-/s2
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n/an/a 6.80E+3n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
The assay was performed on hERG channel stably expressed in HEK293 cells. The cells were cultured at 37 C. in a humidified CO2 incubator in the grow...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM388301
PNG
(US10294230, Compound E1-22.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@H](CNc3ncccn3)C(F)(F)C2)cc1
Show InChI InChI=1S/C19H22F2N4O2/c1-14-3-5-15(6-4-14)12-27-18(26)25-10-7-16(19(20,21)13-25)11-24-17-22-8-2-9-23-17/h2-6,8-9,16H,7,10-13H2,1H3,(H,22,23,24)/t16-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
The assay was performed on hERG channel stably expressed in HEK293 cells. The cells were cultured at 37 C. in a humidified CO2 incubator in the grow...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM388294
PNG
(US10294230, Compound E1-1.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@H](CNc3nccn4cnnc34)C(F)(F)C2)cc1
Show InChI InChI=1S/C20H22F2N6O2/c1-14-2-4-15(5-3-14)11-30-19(29)27-8-6-16(20(21,22)12-27)10-24-17-18-26-25-13-28(18)9-7-23-17/h2-5,7,9,13,16H,6,8,10-12H2,1H3,(H,23,24)/t16-/m1/s1
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n/an/a 4.00E+4n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
The assay was performed on hERG channel stably expressed in HEK293 cells. The cells were cultured at 37 C. in a humidified CO2 incubator in the grow...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens (Human))
BDBM388302
PNG
(US10294230, Compound E1-21.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@H](CNc3cnccn3)C(F)(F)C2)cc1
Show InChI InChI=1S/C19H22F2N4O2/c1-14-2-4-15(5-3-14)12-27-18(26)25-9-6-16(19(20,21)13-25)10-24-17-11-22-7-8-23-17/h2-5,7-8,11,16H,6,9-10,12-13H2,1H3,(H,23,24)/t16-/m1/s1
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n/an/a>1.00E+7n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens (Human))
BDBM388303
PNG
(US10294230, Compound E1-21.26)
Show SMILES Cc1ccc(COC(=O)N2CC[C@H](CNc3cnc(C)cn3)C(F)(F)C2)cc1
Show InChI InChI=1S/C20H24F2N4O2/c1-14-3-5-16(6-4-14)12-28-19(27)26-8-7-17(20(21,22)13-26)10-25-18-11-23-15(2)9-24-18/h3-6,9,11,17H,7-8,10,12-13H2,1-2H3,(H,24,25)/t17-/m1/s1
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n/an/a>1.00E+7n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens (Human))
BDBM388300
PNG
(US10294230, Compound E1-1.4)
Show SMILES Fc1ccc(COC(=O)N2CC[C@H](CNc3nccn4cnnc34)C(F)(F)C2)cc1
Show InChI InChI=1S/C19H19F3N6O2/c20-15-3-1-13(2-4-15)10-30-18(29)27-7-5-14(19(21,22)11-27)9-24-16-17-26-25-12-28(17)8-6-23-16/h1-4,6,8,12,14H,5,7,9-11H2,(H,23,24)/t14-/m1/s1
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n/an/a>1.00E+7n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens (Human))
BDBM388298
PNG
(US10294230, Compound E1-8.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@@H](CNc3ncc4cn[nH]c4n3)C(F)(F)C2)cc1
Show InChI InChI=1/C20H22F2N6O2/c1-13-2-4-14(5-3-13)11-30-19(29)28-7-6-16(20(21,22)12-28)10-24-18-23-8-15-9-25-27-17(15)26-18/h2-5,8-9,16H,6-7,10-12H2,1H3,(H2,23,24,25,26,27)/t16-/s2
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n/an/a>1.00E+7n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens (Human))
BDBM388295
PNG
(US10294230, Compound E2-1.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@@H](CNc3nccn4cnnc34)C(F)(F)C2)cc1
Show InChI InChI=1S/C20H22F2N6O2/c1-14-2-4-15(5-3-14)11-30-19(29)27-8-6-16(20(21,22)12-27)10-24-17-18-26-25-13-28(18)9-7-23-17/h2-5,7,9,13,16H,6,8,10-12H2,1H3,(H,23,24)/t16-/m0/s1
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n/an/a>1.00E+7n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens (Human))
BDBM388299
PNG
(US10294230, Compound E1-1.3)
Show SMILES FC1(F)CN(CC[C@@H]1CNc1nccn2cnnc12)C(=O)OCc1ccc(Cl)cc1
Show InChI InChI=1S/C19H19ClF2N6O2/c20-15-3-1-13(2-4-15)10-30-18(29)27-7-5-14(19(21,22)11-27)9-24-16-17-26-25-12-28(17)8-6-23-16/h1-4,6,8,12,14H,5,7,9-11H2,(H,23,24)/t14-/m1/s1
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n/an/a>1.00E+7n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens (Human))
BDBM388294
PNG
(US10294230, Compound E1-1.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@H](CNc3nccn4cnnc34)C(F)(F)C2)cc1
Show InChI InChI=1S/C20H22F2N6O2/c1-14-2-4-15(5-3-14)11-30-19(29)27-8-6-16(20(21,22)12-27)10-24-17-18-26-25-13-28(18)9-7-23-17/h2-5,7,9,13,16H,6,8,10-12H2,1H3,(H,23,24)/t16-/m1/s1
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n/an/a>1.00E+7n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens (Human))
BDBM388301
PNG
(US10294230, Compound E1-22.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@H](CNc3ncccn3)C(F)(F)C2)cc1
Show InChI InChI=1S/C19H22F2N4O2/c1-14-3-5-15(6-4-14)12-27-18(26)25-10-7-16(19(20,21)13-25)11-24-17-22-8-2-9-23-17/h2-6,8-9,16H,7,10-13H2,1H3,(H,22,23,24)/t16-/m1/s1
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n/an/a>1.00E+7n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens (Human))
BDBM388296
PNG
(US10294230, Compound E1-2.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@@H](CNc3cncc4nncn34)C(F)(F)C2)cc1
Show InChI InChI=1S/C20H22F2N6O2/c1-14-2-4-15(5-3-14)11-30-19(29)27-7-6-16(20(21,22)12-27)8-24-17-9-23-10-18-26-25-13-28(17)18/h2-5,9-10,13,16,24H,6-8,11-12H2,1H3/t16-/m0/s1
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n/an/a>1.00E+7n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
Glutamate [NMDA] receptor


(Homo sapiens (Human))
BDBM388297
PNG
(US10294230, Compound E1-9.2)
Show SMILES Cc1ccc(COC(=O)N2CC[C@@H](CNc3nc4ccccn4n3)C(F)(F)C2)cc1
Show InChI InChI=1S/C21H23F2N5O2/c1-15-5-7-16(8-6-15)13-30-20(29)27-11-9-17(21(22,23)14-27)12-24-19-25-18-4-2-3-10-28(18)26-19/h2-8,10,17H,9,11-14H2,1H3,(H,24,26)/t17-/m0/s1
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n/an/a>1.00E+7n/an/an/an/an/an/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...


US Patent US10294230 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%