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Patent code US10294259

Compile Data Set for Download or QSAR
Found 6 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))		BDBM254941
PNG
(US10294259, Compound Table 3.2 | US9505734, I-D1-6)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)C2OC(C)C(O)C(O)C2O)cc1
Show InChI InChI=1S/C21H25ClO5/c1-3-26-16-7-4-13(5-8-16)10-15-11-14(6-9-17(15)22)21-20(25)19(24)18(23)12(2)27-21/h4-9,11-12,18-21,23-25H,3,10H2,1-2H3
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US Patent
n/an/a 0.670n/an/an/an/an/an/a



Tianjin Institute of Pharmaceutical Research

US Patent


Assay Description
IC50 values of inhibition of some compounds described in the present invention and related compounds on SGLT2 and SGLT1 are determined according to t...

US Patent US10294259 (2019)


BindingDB Entry DOI: 10.7270/Q2QC05V6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))		BDBM388440
PNG
(US10294259, Compound Table 3.1)
Show SMILES COc1ccc(Cc2cc(ccc2Cl)C2OC(C)C(O)C(O)C2O)cc1
Show InChI InChI=1S/C20H23ClO5/c1-11-17(22)18(23)19(24)20(26-11)13-5-8-16(21)14(10-13)9-12-3-6-15(25-2)7-4-12/h3-8,10-11,17-20,22-24H,9H2,1-2H3
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US Patent
n/an/a 3.30n/an/an/an/an/an/a



Tianjin Institute of Pharmaceutical Research

US Patent


Assay Description
IC50 values of inhibition of some compounds described in the present invention and related compounds on SGLT2 and SGLT1 are determined according to t...

US Patent US10294259 (2019)


BindingDB Entry DOI: 10.7270/Q2QC05V6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))		BDBM388442
PNG
(US10294259, Compound Table 3.3)
Show SMILES CCOc1ccc(Cc2cc(ccc2C)C2OC(C)C(O)C(O)C2O)cc1
Show InChI InChI=1S/C22H28O5/c1-4-26-18-9-6-15(7-10-18)11-17-12-16(8-5-13(17)2)22-21(25)20(24)19(23)14(3)27-22/h5-10,12,14,19-25H,4,11H2,1-3H3
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US Patent
n/an/a 7.80n/an/an/an/an/an/a



Tianjin Institute of Pharmaceutical Research

US Patent


Assay Description
IC50 values of inhibition of some compounds described in the present invention and related compounds on SGLT2 and SGLT1 are determined according to t...

US Patent US10294259 (2019)


BindingDB Entry DOI: 10.7270/Q2QC05V6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))		BDBM388440
PNG
(US10294259, Compound Table 3.1)
Show SMILES COc1ccc(Cc2cc(ccc2Cl)C2OC(C)C(O)C(O)C2O)cc1
Show InChI InChI=1S/C20H23ClO5/c1-11-17(22)18(23)19(24)20(26-11)13-5-8-16(21)14(10-13)9-12-3-6-15(25-2)7-4-12/h3-8,10-11,17-20,22-24H,9H2,1-2H3
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PC sid
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US Patent
n/an/a 86n/an/an/an/an/an/a



Tianjin Institute of Pharmaceutical Research

US Patent


Assay Description
IC50 values of inhibition of some compounds described in the present invention and related compounds on SGLT2 and SGLT1 are determined according to t...

US Patent US10294259 (2019)


BindingDB Entry DOI: 10.7270/Q2QC05V6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))		BDBM388442
PNG
(US10294259, Compound Table 3.3)
Show SMILES CCOc1ccc(Cc2cc(ccc2C)C2OC(C)C(O)C(O)C2O)cc1
Show InChI InChI=1S/C22H28O5/c1-4-26-18-9-6-15(7-10-18)11-17-12-16(8-5-13(17)2)22-21(25)20(24)19(23)14(3)27-22/h5-10,12,14,19-25H,4,11H2,1-3H3
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PC cid
PC sid
UniChem
US Patent
n/an/a 187n/an/an/an/an/an/a



Tianjin Institute of Pharmaceutical Research

US Patent


Assay Description
IC50 values of inhibition of some compounds described in the present invention and related compounds on SGLT2 and SGLT1 are determined according to t...

US Patent US10294259 (2019)


BindingDB Entry DOI: 10.7270/Q2QC05V6
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))		BDBM254941
PNG
(US10294259, Compound Table 3.2 | US9505734, I-D1-6)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)C2OC(C)C(O)C(O)C2O)cc1
Show InChI InChI=1S/C21H25ClO5/c1-3-26-16-7-4-13(5-8-16)10-15-11-14(6-9-17(15)22)21-20(25)19(24)18(23)12(2)27-21/h4-9,11-12,18-21,23-25H,3,10H2,1-2H3
Reactome pathway

UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 251n/an/an/an/an/an/a



Tianjin Institute of Pharmaceutical Research

US Patent


Assay Description
IC50 values of inhibition of some compounds described in the present invention and related compounds on SGLT2 and SGLT1 are determined according to t...

US Patent US10294259 (2019)


BindingDB Entry DOI: 10.7270/Q2QC05V6
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%