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Patent code US10300051

Compile Data Set for Download or QSAR
Found 61 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391663
PNG
(3-[4-(4-fluorobenzyl)-4-({[(1R,2S)-2-phenylcyclopr...)
Show SMILES CNC(=O)CCN1CCC(CN[C@@H]2CC2c2ccccc2)(Cc2ccc(F)cc2)CC1
Show InChI InChI=1S/C26H34FN3O/c1-28-25(31)11-14-30-15-12-26(13-16-30,18-20-7-9-22(27)10-8-20)19-29-24-17-23(24)21-5-3-2-4-6-21/h2-10,23-24,29H,11-19H2,1H3,(H,28,31)/t23?,24-/m1/s1
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US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391713
PNG
(3-[4-(3-methoxybenzyl)-4-({[(1R,2S)-2-phenylcyclop...)
Show SMILES COc1cccc(CC2(CN[C@@H]3CC3c3ccccc3)CCN(CCC(O)=O)CC2)c1
Show InChI InChI=1S/C26H34N2O3/c1-31-22-9-5-6-20(16-22)18-26(11-14-28(15-12-26)13-10-25(29)30)19-27-24-17-23(24)21-7-3-2-4-8-21/h2-9,16,23-24,27H,10-15,17-19H2,1H3,(H,29,30)/t23?,24-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391692
PNG
(3-[4-[(3-fluorophenoxy)methyl]-4-({[(1R,2S)-2-phen...)
Show SMILES OC(=O)CCN1CCC(CN[C@@H]2CC2c2ccccc2)(COc2cccc(F)c2)CC1
Show InChI InChI=1S/C25H31FN2O3/c26-20-7-4-8-21(15-20)31-18-25(10-13-28(14-11-25)12-9-24(29)30)17-27-23-16-22(23)19-5-2-1-3-6-19/h1-8,15,22-23,27H,9-14,16-18H2,(H,29,30)/t22?,23-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391698
PNG
(3-[4-[(4-cyanophenoxy)methyl]-4-({[(1R,2S)-2-pheny...)
Show SMILES OC(=O)CCN1CCC(CN[C@@H]2CC2c2ccccc2)(COc2ccc(cc2)C#N)CC1
Show InChI InChI=1S/C26H31N3O3/c27-17-20-6-8-22(9-7-20)32-19-26(11-14-29(15-12-26)13-10-25(30)31)18-28-24-16-23(24)21-4-2-1-3-5-21/h1-9,23-24,28H,10-16,18-19H2,(H,30,31)/t23?,24-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391703
PNG
((1R,2S)—N-{[4-(methoxymethyl)-1-(morpholin-4-...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C(=O)N1CCOCC1
Show InChI InChI=1S/C22H33N3O3/c1-27-17-22(16-23-20-15-19(20)18-5-3-2-4-6-18)7-9-24(10-8-22)21(26)25-11-13-28-14-12-25/h2-6,19-20,23H,7-17H2,1H3/t19?,20-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391715
PNG
((1R,2S)—N-{[4-(methoxymethyl)-1-(morpholin-4-...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C(=O)CN1CCOCC1
Show InChI InChI=1S/C23H35N3O3/c1-28-18-23(17-24-21-15-20(21)19-5-3-2-4-6-19)7-9-26(10-8-23)22(27)16-25-11-13-29-14-12-25/h2-6,20-21,24H,7-18H2,1H3/t20?,21-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391623
PNG
((1-Acetyl-4-{[(trans-2-phenylcyclopropyl)amino]met...)
Show SMILES CC(=O)N1CCC(CNC2CC2c2ccccc2)(CC#N)CC1
Show InChI InChI=1S/C19H25N3O/c1-15(23)22-11-8-19(7-10-20,9-12-22)14-21-18-13-17(18)16-5-3-2-4-6-16/h2-6,17-18,21H,7-9,11-14H2,1H3
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391657
PNG
(4-(Cyanomethyl)-N,N-dimethyl-4-{[(trans-2-phenylcy...)
Show SMILES CN(C)C(=O)N1CCC(CNC2CC2c2ccccc2)(CC#N)CC1
Show InChI InChI=1S/C20H28N4O/c1-23(2)19(25)24-12-9-20(8-11-21,10-13-24)15-22-18-14-17(18)16-6-4-3-5-7-16/h3-7,17-18,22H,8-10,12-15H2,1-2H3
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391666
PNG
((1S,2R)—N-{[4-(4-fluorobenzyl)piperidin-4-yl]...)
Show SMILES Fc1ccc(CC2(CN[C@H]3C[C@@H]3c3ccccc3)CCNCC2)cc1
Show InChI InChI=1S/C22H27FN2/c23-19-8-6-17(7-9-19)15-22(10-12-24-13-11-22)16-25-21-14-20(21)18-4-2-1-3-5-18/h1-9,20-21,24-25H,10-16H2/t20-,21+/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391672
PNG
(3-[4-(2,4-difluorobenzyl)-4-({[(1R,2S)-2-phenylcyc...)
Show SMILES OC(=O)CCN1CCC(CN[C@@H]2CC2c2ccccc2)(Cc2ccc(F)cc2F)CC1
Show InChI InChI=1S/C25H30F2N2O2/c26-20-7-6-19(22(27)14-20)16-25(9-12-29(13-10-25)11-8-24(30)31)17-28-23-15-21(23)18-4-2-1-3-5-18/h1-7,14,21,23,28H,8-13,15-17H2,(H,30,31)/t21?,23-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391676
PNG
(3-[4-(methoxymethyl)-4-({[(1R,2S)-2-phenylcyclopro...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CCC(O)=O)CC1
Show InChI InChI=1S/C20H30N2O3/c1-25-15-20(8-11-22(12-9-20)10-7-19(23)24)14-21-18-13-17(18)16-5-3-2-4-6-16/h2-6,17-18,21H,7-15H2,1H3,(H,23,24)/t17?,18-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391687
PNG
(3-{[4-({[(1R,2S)-2-phenylcyclopropyl]amino}methyl)...)
Show SMILES OC(=O)c1cccc(CC2(CN[C@@H]3CC3c3ccccc3)CCN(Cc3cccnc3)CC2)c1
Show InChI InChI=1S/C29H33N3O2/c33-28(34)25-10-4-6-22(16-25)18-29(21-31-27-17-26(27)24-8-2-1-3-9-24)11-14-32(15-12-29)20-23-7-5-13-30-19-23/h1-10,13,16,19,26-27,31H,11-12,14-15,17-18,20-21H2,(H,33,34)/t26?,27-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391708
PNG
(3-[4-[(5-fluoropyridin-2-yl)methyl]-4-({[(1R,2S)-2...)
Show SMILES OC(=O)CCN1CCC(CN[C@@H]2CC2c2ccccc2)(Cc2ccc(F)cn2)CC1
Show InChI InChI=1S/C24H30FN3O2/c25-19-6-7-20(26-16-19)15-24(9-12-28(13-10-24)11-8-23(29)30)17-27-22-14-21(22)18-4-2-1-3-5-18/h1-7,16,21-22,27H,8-15,17H2,(H,29,30)/t21?,22-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391710
PNG
(3-{[1-(2-cyanoethyl)-4-({[(1R,2S)-2-phenylcyclopro...)
Show SMILES OC(=O)c1cccc(CC2(CN[C@@H]3CC3c3ccccc3)CCN(CCC#N)CC2)c1
Show InChI InChI=1S/C26H31N3O2/c27-12-5-13-29-14-10-26(11-15-29,18-20-6-4-9-22(16-20)25(30)31)19-28-24-17-23(24)21-7-2-1-3-8-21/h1-4,6-9,16,23-24,28H,5,10-11,13-15,17-19H2,(H,30,31)/t23?,24-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391665
PNG
((1R,2S)—N-{[4-(4-fluorobenzyl)piperidin-4-yl]...)
Show SMILES Fc1ccc(CC2(CN[C@@H]3CC3c3ccccc3)CCNCC2)cc1
Show InChI InChI=1S/C22H27FN2/c23-19-8-6-17(7-9-19)15-22(10-12-24-13-11-22)16-25-21-14-20(21)18-4-2-1-3-5-18/h1-9,20-21,24-25H,10-16H2/t20?,21-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391674
PNG
(3-[4-(3,4-difluorobenzyl)-4-({[(1R,2S)-2-phenylcyc...)
Show SMILES OC(=O)CCN1CCC(CN[C@@H]2CC2c2ccccc2)(Cc2ccc(F)c(F)c2)CC1
Show InChI InChI=1S/C25H30F2N2O2/c26-21-7-6-18(14-22(21)27)16-25(9-12-29(13-10-25)11-8-24(30)31)17-28-23-15-20(23)19-4-2-1-3-5-19/h1-7,14,20,23,28H,8-13,15-17H2,(H,30,31)/t20?,23-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391686
PNG
(3-{[4-({[(1R,2S)-2-phenylcyclopropyl]amino}methyl)...)
Show SMILES OC(=O)c1cccc(CC2(CN[C@@H]3CC3c3ccccc3)CCN(Cc3ccccn3)CC2)c1
Show InChI InChI=1S/C29H33N3O2/c33-28(34)24-10-6-7-22(17-24)19-29(21-31-27-18-26(27)23-8-2-1-3-9-23)12-15-32(16-13-29)20-25-11-4-5-14-30-25/h1-11,14,17,26-27,31H,12-13,15-16,18-21H2,(H,33,34)/t26?,27-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391705
PNG
(3-[4-(ethoxymethyl)-4-({[(1R,2S)-2-phenylcycloprop...)
Show SMILES CCOCC1(CN[C@@H]2CC2c2ccccc2)CCN(CCC(O)=O)CC1
Show InChI InChI=1S/C21H32N2O3/c1-2-26-16-21(9-12-23(13-10-21)11-8-20(24)25)15-22-19-14-18(19)17-6-4-3-5-7-17/h3-7,18-19,22H,2,8-16H2,1H3,(H,24,25)/t18?,19-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391707
PNG
(3-[4-[(cyclohexyloxy)methyl]-4-({[(1R,2S)-2-phenyl...)
Show SMILES OC(=O)CCN1CCC(CN[C@@H]2CC2c2ccccc2)(COC2CCCCC2)CC1
Show InChI InChI=1S/C25H38N2O3/c28-24(29)11-14-27-15-12-25(13-16-27,19-30-21-9-5-2-6-10-21)18-26-23-17-22(23)20-7-3-1-4-8-20/h1,3-4,7-8,21-23,26H,2,5-6,9-19H2,(H,28,29)/t22?,23-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391714
PNG
(3-[4-(3-ethoxybenzyl)-4-({[(1R,2S)-2-phenylcyclopr...)
Show SMILES CCOc1cccc(CC2(CN[C@@H]3CC3c3ccccc3)CCN(CCC(O)=O)CC2)c1
Show InChI InChI=1S/C27H36N2O3/c1-2-32-23-10-6-7-21(17-23)19-27(12-15-29(16-13-27)14-11-26(30)31)20-28-25-18-24(25)22-8-4-3-5-9-22/h3-10,17,24-25,28H,2,11-16,18-20H2,1H3,(H,30,31)/t24?,25-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391660
PNG
((4-{[(trans-2-Phenylcyclopropyl)amino]methyl}piper...)
Show SMILES N#CCC1(CNC2CC2c2ccccc2)CCNCC1
Show InChI InChI=1S/C17H23N3/c18-9-6-17(7-10-19-11-8-17)13-20-16-12-15(16)14-4-2-1-3-5-14/h1-5,15-16,19-20H,6-8,10-13H2
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391661
PNG
(US10300051, Example 7 | [4-{[(trans-2-Phenylcyclop...)
Show SMILES N#CCC1(CNC2CC2c2ccccc2)CCN(Cc2cccnc2)CC1
Show InChI InChI=1S/C23H28N4/c24-11-8-23(18-26-22-15-21(22)20-6-2-1-3-7-20)9-13-27(14-10-23)17-19-5-4-12-25-16-19/h1-7,12,16,21-22,26H,8-10,13-15,17-18H2
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391664
PNG
(3-[4-(4-fluorobenzyl)-4-({[(1R,2S)-2-phenylcyclopr...)
Show SMILES CN(C)C(=O)CCN1CCC(CN[C@@H]2CC2c2ccccc2)(Cc2ccc(F)cc2)CC1
Show InChI InChI=1S/C27H36FN3O/c1-30(2)26(32)12-15-31-16-13-27(14-17-31,19-21-8-10-23(28)11-9-21)20-29-25-18-24(25)22-6-4-3-5-7-22/h3-11,24-25,29H,12-20H2,1-2H3/t24?,25-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391697
PNG
(3-[4-[(2-cyanophenoxy)methyl]-4-({[(1R,2S)-2-pheny...)
Show SMILES OC(=O)CCN1CCC(CN[C@@H]2CC2c2ccccc2)(COc2ccccc2C#N)CC1
Show InChI InChI=1S/C26H31N3O3/c27-17-21-8-4-5-9-24(21)32-19-26(11-14-29(15-12-26)13-10-25(30)31)18-28-23-16-22(23)20-6-2-1-3-7-20/h1-9,22-23,28H,10-16,18-19H2,(H,30,31)/t22?,23-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391700
PNG
(3-[4-{[(5-fluoropyrimidin-2-yl)oxy]methyl}-4-({[(1...)
Show SMILES OC(=O)CCN1CCC(CN[C@@H]2CC2c2ccccc2)(COc2ncc(F)cn2)CC1
Show InChI InChI=1S/C23H29FN4O3/c24-18-13-25-22(26-14-18)31-16-23(7-10-28(11-8-23)9-6-21(29)30)15-27-20-12-19(20)17-4-2-1-3-5-17/h1-5,13-14,19-20,27H,6-12,15-16H2,(H,29,30)/t19?,20-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391701
PNG
(3-[4-[(3-cyanophenoxy)methyl]-4-({[(1R,2S)-2-pheny...)
Show SMILES OC(=O)CCN1CCC(CN[C@@H]2CC2c2ccccc2)(COc2cccc(c2)C#N)CC1
Show InChI InChI=1S/C26H31N3O3/c27-17-20-5-4-8-22(15-20)32-19-26(10-13-29(14-11-26)12-9-25(30)31)18-28-24-16-23(24)21-6-2-1-3-7-21/h1-8,15,23-24,28H,9-14,16,18-19H2,(H,30,31)/t23?,24-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391702
PNG
(3-[4-(methoxymethyl)-4-({[(1R,2S)-2-phenylcyclopro...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC(C)(C)C(O)=O)CC1
Show InChI InChI=1S/C22H34N2O3/c1-21(2,20(25)26)15-24-11-9-22(10-12-24,16-27-3)14-23-19-13-18(19)17-7-5-4-6-8-17/h4-8,18-19,23H,9-16H2,1-3H3,(H,25,26)/t18?,19-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391667
PNG
(US10300051, Example 13 | [4-(4-fluorobenzyl)-4-({[...)
Show SMILES OC(=O)CN1CCC(CN[C@@H]2CC2c2ccccc2)(Cc2ccc(F)cc2)CC1
Show InChI InChI=1S/C24H29FN2O2/c25-20-8-6-18(7-9-20)15-24(10-12-27(13-11-24)16-23(28)29)17-26-22-14-21(22)19-4-2-1-3-5-19/h1-9,21-22,26H,10-17H2,(H,28,29)/t21?,22-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391670
PNG
(3-[4-(2-fluorobenzyl)-4-({[(1R,2S)-2-phenylcyclopr...)
Show SMILES OC(=O)CCN1CCC(CN[C@@H]2CC2c2ccccc2)(Cc2ccccc2F)CC1
Show InChI InChI=1S/C25H31FN2O2/c26-22-9-5-4-8-20(22)17-25(11-14-28(15-12-25)13-10-24(29)30)18-27-23-16-21(23)19-6-2-1-3-7-19/h1-9,21,23,27H,10-18H2,(H,29,30)/t21?,23-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391682
PNG
(3-{[1-methyl-4-({[(1R,2S)-2-phenylcyclopropyl]amin...)
Show SMILES CN1CCC(CN[C@@H]2CC2c2ccccc2)(Cc2cccc(c2)C(O)=O)CC1
Show InChI InChI=1S/C24H30N2O2/c1-26-12-10-24(11-13-26,16-18-6-5-9-20(14-18)23(27)28)17-25-22-15-21(22)19-7-3-2-4-8-19/h2-9,14,21-22,25H,10-13,15-17H2,1H3,(H,27,28)/t21?,22-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391689
PNG
(3-(4-({[(1R,2S)-2-phenylcyclopropyl]amino}methyl)-...)
Show SMILES OC(=O)CCN1CCC(CN[C@@H]2CC2c2ccccc2)(Cc2cccc(O[C@@H]3CCOC3)c2)CC1
Show InChI InChI=1S/C29H38N2O4/c32-28(33)9-13-31-14-11-29(12-15-31,21-30-27-18-26(27)23-6-2-1-3-7-23)19-22-5-4-8-24(17-22)35-25-10-16-34-20-25/h1-8,17,25-27,30H,9-16,18-21H2,(H,32,33)/t25-,26?,27-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391693
PNG
(3-[4-[(4-fluorophenoxy)methyl]-4-({[(1R,2S)-2-phen...)
Show SMILES OC(=O)CCN1CCC(CN[C@@H]2CC2c2ccccc2)(COc2ccc(F)cc2)CC1
Show InChI InChI=1S/C25H31FN2O3/c26-20-6-8-21(9-7-20)31-18-25(11-14-28(15-12-25)13-10-24(29)30)17-27-23-16-22(23)19-4-2-1-3-5-19/h1-9,22-23,27H,10-18H2,(H,29,30)/t22?,23-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391694
PNG
(3-[4-[(benzyloxy)methyl]-4-({[(1R,2S)-2-phenylcycl...)
Show SMILES OC(=O)CCN1CCC(CN[C@@H]2CC2c2ccccc2)(COCc2ccccc2)CC1
Show InChI InChI=1S/C26H34N2O3/c29-25(30)11-14-28-15-12-26(13-16-28,20-31-18-21-7-3-1-4-8-21)19-27-24-17-23(24)22-9-5-2-6-10-22/h1-10,23-24,27H,11-20H2,(H,29,30)/t23?,24-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391699
PNG
(3-[4-{[(5-fluoropyridin-2-yl)oxy]methyl}-4-({[(1R,...)
Show SMILES OC(=O)CCN1CCC(CN[C@@H]2CC2c2ccccc2)(COc2ccc(F)cn2)CC1
Show InChI InChI=1S/C24H30FN3O3/c25-19-6-7-22(26-15-19)31-17-24(9-12-28(13-10-24)11-8-23(29)30)16-27-21-14-20(21)18-4-2-1-3-5-18/h1-7,15,20-21,27H,8-14,16-17H2,(H,29,30)/t20?,21-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391709
PNG
(3-[4-(4-methoxybenzyl)-4-({[(1R,2S)-2-phenylcyclop...)
Show SMILES COc1ccc(CC2(CN[C@@H]3CC3c3ccccc3)CCN(CCC(O)=O)CC2)cc1
Show InChI InChI=1S/C26H34N2O3/c1-31-22-9-7-20(8-10-22)18-26(12-15-28(16-13-26)14-11-25(29)30)19-27-24-17-23(24)21-5-3-2-4-6-21/h2-10,23-24,27H,11-19H2,1H3,(H,29,30)/t23?,24-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391712
PNG
(3-{[1-[(dimethylamino)acetyl]-4-({[(1R,2S)-2-pheny...)
Show SMILES CN(C)CC(=O)N1CCC(CN[C@@H]2CC2c2ccccc2)(Cc2cccc(c2)C(N)=O)CC1
Show InChI InChI=1S/C27H36N4O2/c1-30(2)18-25(32)31-13-11-27(12-14-31,17-20-7-6-10-22(15-20)26(28)33)19-29-24-16-23(24)21-8-4-3-5-9-21/h3-10,15,23-24,29H,11-14,16-19H2,1-2H3,(H2,28,33)/t23?,24-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391658
PNG
((1-(Methylsulfonyl)-4-{[(trans-2-phenylcyclopropyl...)
Show SMILES CS(=O)(=O)N1CCC(CNC2CC2c2ccccc2)(CC#N)CC1
Show InChI InChI=1S/C18H25N3O2S/c1-24(22,23)21-11-8-18(7-10-19,9-12-21)14-20-17-13-16(17)15-5-3-2-4-6-15/h2-6,16-17,20H,7-9,11-14H2,1H3
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391659
PNG
((1-Methyl-4-{[(trans-2-phenylcyclopropyl)amino]met...)
Show SMILES CN1CCC(CNC2CC2c2ccccc2)(CC#N)CC1
Show InChI InChI=1S/C18H25N3/c1-21-11-8-18(7-10-19,9-12-21)14-20-17-13-16(17)15-5-3-2-4-6-15/h2-6,16-17,20H,7-9,11-14H2,1H3
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391671
PNG
(3-[4-(3-fluorobenzyl)-4-({[(1R,2S)-2-phenylcyclopr...)
Show SMILES OC(=O)CCN1CCC(CN[C@@H]2CC2c2ccccc2)(Cc2cccc(F)c2)CC1
Show InChI InChI=1S/C25H31FN2O2/c26-21-8-4-5-19(15-21)17-25(10-13-28(14-11-25)12-9-24(29)30)18-27-23-16-22(23)20-6-2-1-3-7-20/h1-8,15,22-23,27H,9-14,16-18H2,(H,29,30)/t22?,23-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391690
PNG
(3-{4-({[(1R,2S)-2-phenylcyclopropyl]amino}methyl)-...)
Show SMILES OC(=O)CCN1CCC(CN[C@@H]2CC2c2ccccc2)(Cc2cccc(OC3CCOCC3)c2)CC1
Show InChI InChI=1S/C30H40N2O4/c33-29(34)9-14-32-15-12-30(13-16-32,22-31-28-20-27(28)24-6-2-1-3-7-24)21-23-5-4-8-26(19-23)36-25-10-17-35-18-11-25/h1-8,19,25,27-28,31H,9-18,20-22H2,(H,33,34)/t27?,28-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391691
PNG
(3-[4-[(2-fluorophenoxy)methyl]-4-({[(1R,2S)-2-phen...)
Show SMILES OC(=O)CCN1CCC(CN[C@@H]2CC2c2ccccc2)(COc2ccccc2F)CC1
Show InChI InChI=1S/C25H31FN2O3/c26-21-8-4-5-9-23(21)31-18-25(11-14-28(15-12-25)13-10-24(29)30)17-27-22-16-20(22)19-6-2-1-3-7-19/h1-9,20,22,27H,10-18H2,(H,29,30)/t20?,22-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391706
PNG
(3-[4-[(cyclobutylmethoxy)methyl]-4-({[(1R,2S)-2-ph...)
Show SMILES OC(=O)CCN1CCC(CN[C@@H]2CC2c2ccccc2)(COCC2CCC2)CC1
Show InChI InChI=1S/C24H36N2O3/c27-23(28)9-12-26-13-10-24(11-14-26,18-29-16-19-5-4-6-19)17-25-22-15-21(22)20-7-2-1-3-8-20/h1-3,7-8,19,21-22,25H,4-6,9-18H2,(H,27,28)/t21?,22-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391668
PNG
((1R,2S)—N-{[1-[(2S)-2-aminopropanoyl]-4-(4-fl...)
Show SMILES C[C@H](N)C(=O)N1CCC(CN[C@@H]2CC2c2ccccc2)(Cc2ccc(F)cc2)CC1
Show InChI InChI=1S/C25H32FN3O/c1-18(27)24(30)29-13-11-25(12-14-29,16-19-7-9-21(26)10-8-19)17-28-23-15-22(23)20-5-3-2-4-6-20/h2-10,18,22-23,28H,11-17,27H2,1H3/t18-,22?,23+/m0/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391669
PNG
((1R,2S)—N-{[1-[(2R)-2-aminopropanoyl]-4-(4-fl...)
Show SMILES C[C@@H](N)C(=O)N1CCC(CN[C@@H]2CC2c2ccccc2)(Cc2ccc(F)cc2)CC1
Show InChI InChI=1S/C25H32FN3O/c1-18(27)24(30)29-13-11-25(12-14-29,16-19-7-9-21(26)10-8-19)17-28-23-15-22(23)20-5-3-2-4-6-20/h2-10,18,22-23,28H,11-17,27H2,1H3/t18-,22?,23-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391675
PNG
((1R,2S)—N-{[4-(methoxymethyl)piperidin-4-yl]m...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCNCC1
Show InChI InChI=1S/C17H26N2O/c1-20-13-17(7-9-18-10-8-17)12-19-16-11-15(16)14-5-3-2-4-6-14/h2-6,15-16,18-19H,7-13H2,1H3/t15?,16-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391677
PNG
(3-[4-(methoxymethyl)-4-({[(1R,2S)-2-phenylcyclopro...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CCC(=O)N(C)C)CC1
Show InChI InChI=1S/C22H35N3O2/c1-24(2)21(26)9-12-25-13-10-22(11-14-25,17-27-3)16-23-20-15-19(20)18-7-5-4-6-8-18/h4-8,19-20,23H,9-17H2,1-3H3/t19?,20-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391684
PNG
(3-{[1-(cyclopropylmethyl)-4-({[(1R,2S)-2-phenylcyc...)
Show SMILES OC(=O)c1cccc(CC2(CN[C@@H]3CC3c3ccccc3)CCN(CC3CC3)CC2)c1
Show InChI InChI=1S/C27H34N2O2/c30-26(31)23-8-4-5-21(15-23)17-27(11-13-29(14-12-27)18-20-9-10-20)19-28-25-16-24(25)22-6-2-1-3-7-22/h1-8,15,20,24-25,28H,9-14,16-19H2,(H,30,31)/t24?,25-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391685
PNG
(3-{[4-({[(1R,2S)-2-phenylcyclopropyl]amino}methyl)...)
Show SMILES OC(=O)c1cccc(CC2(CN[C@@H]3CC3c3ccccc3)CCN(CC2)C2CCOCC2)c1
Show InChI InChI=1S/C28H36N2O3/c31-27(32)23-8-4-5-21(17-23)19-28(11-13-30(14-12-28)24-9-15-33-16-10-24)20-29-26-18-25(26)22-6-2-1-3-7-22/h1-8,17,24-26,29H,9-16,18-20H2,(H,31,32)/t25?,26-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391695
PNG
(3-[4-(4-cyanobenzyl)-4-({[(1R,2S)-2-phenylcyclopro...)
Show SMILES OC(=O)CCN1CCC(CN[C@@H]2CC2c2ccccc2)(Cc2ccc(cc2)C#N)CC1
Show InChI InChI=1S/C26H31N3O2/c27-18-21-8-6-20(7-9-21)17-26(11-14-29(15-12-26)13-10-25(30)31)19-28-24-16-23(24)22-4-2-1-3-5-22/h1-9,23-24,28H,10-17,19H2,(H,30,31)/t23?,24-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391696
PNG
(3-[4-(4-cyano-2-fluorobenzyl)-4-({[(1R,2S)-2-pheny...)
Show SMILES OC(=O)CCN1CCC(CN[C@@H]2CC2c2ccccc2)(Cc2ccc(cc2F)C#N)CC1
Show InChI InChI=1S/C26H30FN3O2/c27-23-14-19(17-28)6-7-21(23)16-26(9-12-30(13-10-26)11-8-25(31)32)18-29-24-15-22(24)20-4-2-1-3-5-20/h1-7,14,22,24,29H,8-13,15-16,18H2,(H,31,32)/t22?,24-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391704
PNG
(3-[4-[(6-methoxypyridin-3-yl)methyl]-4-({[(1R,2S)-...)
Show SMILES COc1ccc(CC2(CN[C@@H]3CC3c3ccccc3)CCN(CCC(O)=O)CC2)cn1
Show InChI InChI=1S/C25H33N3O3/c1-31-23-8-7-19(17-26-23)16-25(10-13-28(14-11-25)12-9-24(29)30)18-27-22-15-21(22)20-5-3-2-4-6-20/h2-8,17,21-22,27H,9-16,18H2,1H3,(H,29,30)/t21?,22-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391633
PNG
(Methyl 4-(cyanomethyl)-4-{[(trans-2-phenylcyclopro...)
Show SMILES COC(=O)N1CCC(CNC2CC2c2ccccc2)(CC#N)CC1
Show InChI InChI=1S/C19H25N3O2/c1-24-18(23)22-11-8-19(7-10-20,9-12-22)14-21-17-13-16(17)15-5-3-2-4-6-15/h2-6,16-17,21H,7-9,11-14H2,1H3
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391662
PNG
(3-[4-(4-fluorobenzyl)-4-({[(1R,2S)-2-phenylcyclopr...)
Show SMILES OC(=O)CCN1CCC(CN[C@@H]2CC2c2ccccc2)(Cc2ccc(F)cc2)CC1
Show InChI InChI=1S/C25H31FN2O2/c26-21-8-6-19(7-9-21)17-25(11-14-28(15-12-25)13-10-24(29)30)18-27-23-16-22(23)20-4-2-1-3-5-20/h1-9,22-23,27H,10-18H2,(H,29,30)/t22?,23-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391673
PNG
(3-[4-(2,3-difluorobenzyl)-4-({[(1R,2S)-2-phenylcyc...)
Show SMILES OC(=O)CCN1CCC(CN[C@@H]2CC2c2ccccc2)(Cc2cccc(F)c2F)CC1
Show InChI InChI=1S/C25H30F2N2O2/c26-21-8-4-7-19(24(21)27)16-25(10-13-29(14-11-25)12-9-23(30)31)17-28-22-15-20(22)18-5-2-1-3-6-18/h1-8,20,22,28H,9-17H2,(H,30,31)/t20?,22-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391678
PNG
(3-[4-(methoxymethyl)-4-({[(1R,2S)-2-phenylcyclopro...)
Show SMILES CNC(=O)CCN1CCC(CN[C@@H]2CC2c2ccccc2)(COC)CC1
Show InChI InChI=1S/C21H33N3O2/c1-22-20(25)8-11-24-12-9-21(10-13-24,16-26-2)15-23-19-14-18(19)17-6-4-3-5-7-17/h3-7,18-19,23H,8-16H2,1-2H3,(H,22,25)/t18?,19-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391679
PNG
(3-[4-[4-(cyanomethyl)benzyl]-4-({[(1R,2S)-2-phenyl...)
Show SMILES OC(=O)CCN1CCC(CN[C@@H]2CC2c2ccccc2)(Cc2ccc(CC#N)cc2)CC1
Show InChI InChI=1S/C27H33N3O2/c28-14-10-21-6-8-22(9-7-21)19-27(12-16-30(17-13-27)15-11-26(31)32)20-29-25-18-24(25)23-4-2-1-3-5-23/h1-9,24-25,29H,10-13,15-20H2,(H,31,32)/t24?,25-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391680
PNG
(3-[4-[4-(1-cyanocyclopropyl)benzyl]-4-({[(1R,2S)-2...)
Show SMILES OC(=O)CCN1CCC(CN[C@@H]2CC2c2ccccc2)(Cc2ccc(cc2)C2(CC2)C#N)CC1
Show InChI InChI=1S/C29H35N3O2/c30-20-29(11-12-29)24-8-6-22(7-9-24)19-28(13-16-32(17-14-28)15-10-27(33)34)21-31-26-18-25(26)23-4-2-1-3-5-23/h1-9,25-26,31H,10-19,21H2,(H,33,34)/t25?,26-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391681
PNG
(3-[4-[3-(1-methyl-1H-pyrazol-4-yl)benzyl]-4-({[(1R...)
Show SMILES Cn1cc(cn1)-c1cccc(CC2(CN[C@@H]3CC3c3ccccc3)CCN(CCC(O)=O)CC2)c1
Show InChI InChI=1S/C29H36N4O2/c1-32-20-25(19-31-32)24-9-5-6-22(16-24)18-29(11-14-33(15-12-29)13-10-28(34)35)21-30-27-17-26(27)23-7-3-2-4-8-23/h2-9,16,19-20,26-27,30H,10-15,17-18,21H2,1H3,(H,34,35)/t26?,27-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391683
PNG
(3-{[1-ethyl-4-({[(1R,2S)-2-phenylcyclopropyl]amino...)
Show SMILES CCN1CCC(CN[C@@H]2CC2c2ccccc2)(Cc2cccc(c2)C(O)=O)CC1
Show InChI InChI=1S/C25H32N2O2/c1-2-27-13-11-25(12-14-27,17-19-7-6-10-21(15-19)24(28)29)18-26-23-16-22(23)20-8-4-3-5-9-20/h3-10,15,22-23,26H,2,11-14,16-18H2,1H3,(H,28,29)/t22?,23-/m1/s1
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Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391711
PNG
(3-{[1-[(dimethylamino)acetyl]-4-({[(1R,2S)-2-pheny...)
Show SMILES CN(C)CC(=O)N1CCC(CN[C@@H]2CC2c2ccccc2)(Cc2cccc(c2)C#N)CC1
Show InChI InChI=1S/C27H34N4O/c1-30(2)19-26(32)31-13-11-27(12-14-31,17-21-7-6-8-22(15-21)18-28)20-29-25-16-24(25)23-9-4-3-5-10-23/h3-10,15,24-25,29H,11-14,16-17,19-20H2,1-2H3/t24?,25-/m1/s1
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Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM391688
PNG
(3-{[1-isopropyl-4-({[(1R,2S)-2-phenylcyclopropyl]a...)
Show SMILES CC(C)N1CCC(CN[C@@H]2CC2c2ccccc2)(Cc2cccc(c2)C(O)=O)CC1
Show InChI InChI=1S/C26H34N2O2/c1-19(2)28-13-11-26(12-14-28,17-20-7-6-10-22(15-20)25(29)30)18-27-24-16-23(24)21-8-4-3-5-9-21/h3-10,15,19,23-24,27H,11-14,16-18H2,1-2H3,(H,29,30)/t23?,24-/m1/s1
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Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10300051 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%