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Patent code US10300056

Compile Data Set for Download or QSAR
Found 14 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calcitonin-gene-related peptide receptor, CALCRL/RAMP1


(Homo sapiens (Human))
BDBM391716
PNG
(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 1 | ...)
Show SMILES Cc1cc(C[C@@H](NC(=O)N2CCC(CC2)n2c3cccnc3[nH]c2=O)C(=O)N[C@@H](CC2CCNCC2)C(=O)N2CCN(CC2)c2ccncc2)cc2cn[nH]c12
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0.0200n/an/an/an/an/an/an/an/a



Heptares Therapeutics Limited

US Patent


Assay Description
Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...


US Patent US10300056 (2019)


BindingDB Entry DOI: 10.7270/Q2T155ZX
More data for this
Ligand-Target Pair
Calcitonin-gene-related peptide receptor, CALCRL/RAMP1


(Homo sapiens (Human))
BDBM391727
PNG
(N-[(2R)-1-({(2S)-3-{1-[2- | US10300056, Example 12...)
Show SMILES CN(C)CCN1CCC(C[C@H](NC(=O)[C@@H](Cc2cc(C)c3[nH]ncc3c2)NC(=O)N2CCC(CC2)n2c3cccnc3[nH]c2=O)C(=O)N2CCN(CC2)c2ccncc2)CC1
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0.0250n/an/an/an/an/an/an/an/a



Heptares Therapeutics Limited

US Patent


Assay Description
Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...


US Patent US10300056 (2019)


BindingDB Entry DOI: 10.7270/Q2T155ZX
More data for this
Ligand-Target Pair
Calcitonin-gene-related peptide receptor, CALCRL/RAMP1


(Homo sapiens (Human))
BDBM391726
PNG
(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 11 |...)
Show SMILES Cc1cc(C[C@@H](NC(=O)N2CCC3(CC2)OC(=O)Nc2ncccc32)C(=O)N[C@@H](CC2CCNCC2)C(=O)N2CCN(CC2)c2ccncc2)cc2cn[nH]c12
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0.0320n/an/an/an/an/an/an/an/a



Heptares Therapeutics Limited

US Patent


Assay Description
Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...


US Patent US10300056 (2019)


BindingDB Entry DOI: 10.7270/Q2T155ZX
More data for this
Ligand-Target Pair
Calcitonin-gene-related peptide receptor, CALCRL/RAMP1


(Homo sapiens (Human))
BDBM391723
PNG
(3,5-dibromo-Nalpha-{[4-(2- | US10300056, Example 8...)
Show SMILES Oc1c(Br)cc(C[C@@H](NC(=O)N2CCC(CC2)n2c3cccnc3[nH]c2=O)C(=O)N[C@@H](CC2CCNCC2)C(=O)N2CCN(CC2)c2ccncc2)cc1Br
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0.0400n/an/an/an/an/an/an/an/a



Heptares Therapeutics Limited

US Patent


Assay Description
Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...


US Patent US10300056 (2019)


BindingDB Entry DOI: 10.7270/Q2T155ZX
More data for this
Ligand-Target Pair
Calcitonin-gene-related peptide receptor, CALCRL/RAMP1


(Homo sapiens (Human))
BDBM391719
PNG
(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 4 | ...)
Show SMILES CCCN1CCC(C[C@H](NC(=O)[C@@H](Cc2cc(C)c3[nH]ncc3c2)NC(=O)N2CCC(CC2)c2cc3ccccc3[nH]c2=O)C(=O)N2CCN(CC2)c2ccncc2)CC1
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0.0400n/an/an/an/an/an/an/an/a



Heptares Therapeutics Limited

US Patent


Assay Description
Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...


US Patent US10300056 (2019)


BindingDB Entry DOI: 10.7270/Q2T155ZX
More data for this
Ligand-Target Pair
Calcitonin-gene-related peptide receptor, CALCRL/RAMP1


(Homo sapiens (Human))
BDBM391722
PNG
(N-[(2R)-1-({(2S)-3-(1- | US10300056, Example 7 | U...)
Show SMILES CCN1CCC(C[C@H](NC(=O)[C@@H](Cc2cc(C)c3[nH]ncc3c2)NC(=O)N2CCC(CC2)c2cc3ccccc3[nH]c2=O)C(=O)N2CCN(CC2)c2ccncc2)CC1
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0.0400n/an/an/an/an/an/an/an/a



Heptares Therapeutics Limited

US Patent


Assay Description
Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...


US Patent US10300056 (2019)


BindingDB Entry DOI: 10.7270/Q2T155ZX
More data for this
Ligand-Target Pair
Calcitonin-gene-related peptide receptor, CALCRL/RAMP1


(Homo sapiens (Human))
BDBM391725
PNG
(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 10 |...)
Show SMILES Cc1cc(C[C@@H](NC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C(=O)N[C@@H](CC2CCNCC2)C(=O)N2CCN(CC2)c2ccncc2)cc2cn[nH]c12
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0.0630n/an/an/an/an/an/an/an/a



Heptares Therapeutics Limited

US Patent


Assay Description
Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...


US Patent US10300056 (2019)


BindingDB Entry DOI: 10.7270/Q2T155ZX
More data for this
Ligand-Target Pair
Calcitonin-gene-related peptide receptor, CALCRL/RAMP1


(Homo sapiens (Human))
BDBM391720
PNG
(3,5-dibromo-Nalpha-{[4-(2- | US10300056, Example 5...)
Show SMILES Oc1c(Br)cc(C[C@@H](NC(=O)N2CCC(CC2)c2cc3ccccc3[nH]c2=O)C(=O)N[C@@H](CC2CCNCC2)C(=O)N2CCN(CC2)c2ccncc2)cc1Br
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0.0630n/an/an/an/an/an/an/an/a



Heptares Therapeutics Limited

US Patent


Assay Description
Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...


US Patent US10300056 (2019)


BindingDB Entry DOI: 10.7270/Q2T155ZX
More data for this
Ligand-Target Pair
Calcitonin-gene-related peptide receptor, CALCRL/RAMP1


(Homo sapiens (Human))
BDBM391729
PNG
(3,5-dibromo-Nalpha-[(2'-oxo- | US10300056, Example...)
Show SMILES Oc1c(Br)cc(C[C@@H](NC(=O)N2CCC3(CC2)OC(=O)Nc2ncccc32)C(=O)N[C@@H](CC2CCNCC2)C(=O)N2CCN(CC2)c2ccncc2)cc1Br
Show InChI InChI=1S/C38H45Br2N9O6/c39-28-20-25(21-29(40)32(28)50)23-30(45-36(53)49-14-7-38(8-15-49)27-2-1-9-43-33(27)46-37(54)55-38)34(51)44-31(22-24-3-10-41-11-4-24)35(52)48-18-16-47(17-19-48)26-5-12-42-13-6-26/h1-2,5-6,9,12-13,20-21,24,30-31,41,50H,3-4,7-8,10-11,14-19,22-23H2,(H,44,51)(H,45,53)(H,43,46,54)/t30-,31+/m1/s1
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0.0790n/an/an/an/an/an/an/an/a



Heptares Therapeutics Limited

US Patent


Assay Description
Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...


US Patent US10300056 (2019)


BindingDB Entry DOI: 10.7270/Q2T155ZX
More data for this
Ligand-Target Pair
Calcitonin-gene-related peptide receptor, CALCRL/RAMP1


(Homo sapiens (Human))
BDBM391724
PNG
(3,5-dibromo-Nalpha-{[4-(2- | US10300056, Example 9...)
Show SMILES Oc1c(Br)cc(C[C@@H](NC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C(=O)N[C@@H](CC2CCNCC2)C(=O)N2CCN(CC2)c2ccncc2)cc1Br
Show InChI InChI=1S/C40H49Br2N9O5/c41-31-21-27(22-32(42)36(31)52)24-34(47-39(55)50-15-9-30(10-16-50)51-25-28-3-1-2-4-33(28)46-40(51)56)37(53)45-35(23-26-5-11-43-12-6-26)38(54)49-19-17-48(18-20-49)29-7-13-44-14-8-29/h1-4,7-8,13-14,21-22,26,30,34-35,43,52H,5-6,9-12,15-20,23-25H2,(H,45,53)(H,46,56)(H,47,55)/t34-,35+/m1/s1
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0.0790n/an/an/an/an/an/an/an/a



Heptares Therapeutics Limited

US Patent


Assay Description
Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...


US Patent US10300056 (2019)


BindingDB Entry DOI: 10.7270/Q2T155ZX
More data for this
Ligand-Target Pair
Calcitonin-gene-related peptide receptor, CALCRL/RAMP1


(Homo sapiens (Human))
BDBM391718
PNG
(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 3 | ...)
Show SMILES Cc1cc(C[C@@H](NC(=O)N2CCC(CC2)c2cc3ccccc3[nH]c2=O)C(=O)N[C@@H](CC2CCNCC2)C(=O)N2CCN(CC2)c2ccncc2)cc2cn[nH]c12
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0.0790n/an/an/an/an/an/an/an/a



Heptares Therapeutics Limited

US Patent


Assay Description
Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...


US Patent US10300056 (2019)


BindingDB Entry DOI: 10.7270/Q2T155ZX
More data for this
Ligand-Target Pair
Calcitonin-gene-related peptide receptor, CALCRL/RAMP1


(Homo sapiens (Human))
BDBM391728
PNG
(3-(4-{(2S)-2-{[(2R)-3-(7- | US10300056, Example 13...)
Show SMILES Cc1cc(C[C@@H](NC(=O)N2CCC(CC2)n2c3cccnc3[nH]c2=O)C(=O)N[C@@H](CC2CCN(CC2)C(=O)CC([O-])=O)C(=O)N2CCN(CC2)c2ccncc2)cc2cn[nH]c12
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0.100n/an/an/an/an/an/an/an/a



Heptares Therapeutics Limited

US Patent


Assay Description
Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...


US Patent US10300056 (2019)


BindingDB Entry DOI: 10.7270/Q2T155ZX
More data for this
Ligand-Target Pair
Calcitonin-gene-related peptide receptor, CALCRL/RAMP1


(Homo sapiens (Human))
BDBM391721
PNG
(N-[(2R)-3-(7-methyl-1H- | US10300056, Example 6 | ...)
Show SMILES CCCCC(=O)N1CCC(C[C@H](NC(=O)[C@@H](Cc2cc(C)c3[nH]ncc3c2)NC(=O)N2CCC(CC2)c2cc3ccccc3[nH]c2=O)C(=O)N2CCN(CC2)c2ccncc2)CC1
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0.100n/an/an/an/an/an/an/an/a



Heptares Therapeutics Limited

US Patent


Assay Description
Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...


US Patent US10300056 (2019)


BindingDB Entry DOI: 10.7270/Q2T155ZX
More data for this
Ligand-Target Pair
Calcitonin-gene-related peptide receptor, CALCRL/RAMP1


(Homo sapiens (Human))
BDBM391717
PNG
(US10300056, Example 2 | US10888561, Example 2 | te...)
Show SMILES Cc1cc(C[C@@H](NC(=O)N2CCC(CC2)c2cc3ccccc3[nH]c2=O)C(=O)N[C@@H](CC2CCN(CC2)C(=O)OC(C)(C)C)C(=O)N2CCN(CC2)c2ccncc2)cc2cn[nH]c12
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0.100n/an/an/an/an/an/an/an/a



Heptares Therapeutics Limited

US Patent


Assay Description
Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...


US Patent US10300056 (2019)


BindingDB Entry DOI: 10.7270/Q2T155ZX
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%