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Patent code US10300067

Compile Data Set for Download or QSAR
Found 53 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Androgen Receptor


(Homo sapiens (Human))
BDBM391789
PNG
(4-(4-((5-(4-(2-Hydroxypropan-2-yl)piperidin-1-carb...)
Show SMILES CC(C)(O)C1CCN(CC1)C(=O)c1cnc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)o1
Show InChI InChI=1S/C27H28F3N7O3/c1-26(2,39)17-5-8-36(9-6-17)24(38)22-13-32-25(40-22)35-23-19-7-10-37(14-21(19)33-15-34-23)18-4-3-16(12-31)20(11-18)27(28,29)30/h3-4,11,13,15,17,39H,5-10,14H2,1-2H3,(H,32,33,34,35)
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n/an/a 0n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391797
PNG
(6-((7-(3-Chloro-4-cyanophenyl)-5,6,7,8-tetrahydrop...)
Show SMILES FC(F)(F)CNC(=O)c1ccc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(Cl)c2)nn1
Show InChI InChI=1S/C21H16ClF3N8O/c22-15-7-13(2-1-12(15)8-26)33-6-5-14-17(9-33)28-11-29-19(14)30-18-4-3-16(31-32-18)20(34)27-10-21(23,24)25/h1-4,7,11H,5-6,9-10H2,(H,27,34)(H,28,29,30,32)
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n/an/a 2n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391776
PNG
(6-((7-(4-Cyano-3-(trifluoromethyl)phenyl)-5,6,7,8-...)
Show SMILES FC(F)CNC(=O)c1ccc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)nn1
Show InChI InChI=1S/C22H17F5N8O/c23-18(24)9-29-21(36)16-3-4-19(34-33-16)32-20-14-5-6-35(10-17(14)30-11-31-20)13-2-1-12(8-28)15(7-13)22(25,26)27/h1-4,7,11,18H,5-6,9-10H2,(H,29,36)(H,30,31,32,34)
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391759
PNG
(6-((7-(4-Cyano-3-(trifluoromethyl)phenyl)-5,6,7,8,...)
Show SMILES FC(F)(F)CNC(=O)c1ccc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)nc1
Show InChI InChI=1S/C23H17F6N7O/c24-22(25,26)11-32-21(37)14-2-4-19(31-9-14)35-20-16-5-6-36(10-18(16)33-12-34-20)15-3-1-13(8-30)17(7-15)23(27,28)29/h1-4,7,9,12H,5-6,10-11H2,(H,32,37)(H,31,33,34,35)
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n/an/a 30n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391792
PNG
(2-Bromo-4-(4-((5-(2-hydroxypropan-2-yl)pyridin-2-y...)
Show SMILES CC(C)(O)c1ccc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(Br)c2)nc1
Show InChI InChI=1S/C22H21BrN6O/c1-22(2,30)15-4-6-20(25-11-15)28-21-17-7-8-29(12-19(17)26-13-27-21)16-5-3-14(10-24)18(23)9-16/h3-6,9,11,13,30H,7-8,12H2,1-2H3,(H,25,26,27,28)
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391802
PNG
(2-Chloro-4-(4-((5-(2-methyl-2-(1H-tetrazol-1-yl)pr...)
Show SMILES CC(C)(COc1ccc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(Cl)c2)nc1)n1cnnn1
Show InChI InChI=1S/C24H23ClN10O/c1-24(2,35-15-30-32-33-35)13-36-18-5-6-22(27-11-18)31-23-19-7-8-34(12-21(19)28-14-29-23)17-4-3-16(10-26)20(25)9-17/h3-6,9,11,14-15H,7-8,12-13H2,1-2H3,(H,27,28,29,31)
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n/an/a 55n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391779
PNG
(6-((7-(4-Cyano-3-(trifluoromethyl)phenyl)-5,6,7,8-...)
Show SMILES CC(C)(O)CNC(=O)c1ccc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)nn1
Show InChI InChI=1S/C24H23F3N8O2/c1-23(2,37)12-29-22(36)18-5-6-20(34-33-18)32-21-16-7-8-35(11-19(16)30-13-31-21)15-4-3-14(10-28)17(9-15)24(25,26)27/h3-6,9,13,37H,7-8,11-12H2,1-2H3,(H,29,36)(H,30,31,32,34)
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391774
PNG
(2-((7-(4-Cyano-3-(trifluoromethyl)phenyl)-5,6,7,8-...)
Show SMILES FC(F)(F)CNC(=O)c1sc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)nc1C(F)(F)F
Show InChI InChI=1S/C22H14F9N7OS/c23-20(24,25)8-33-18(39)15-16(22(29,30)31)36-19(40-15)37-17-12-3-4-38(7-14(12)34-9-35-17)11-2-1-10(6-32)13(5-11)21(26,27)28/h1-2,5,9H,3-4,7-8H2,(H,33,39)(H,34,35,36,37)
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391752
PNG
(2-Chloro-4-(4-((6-(2-hydroxypropan-2-yl)pyridazin-...)
Show SMILES CC(C)(O)c1ccc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(Cl)c2)nn1
Show InChI InChI=1S/C21H20ClN7O/c1-21(2,30)18-5-6-19(28-27-18)26-20-15-7-8-29(11-17(15)24-12-25-20)14-4-3-13(10-23)16(22)9-14/h3-6,9,12,30H,7-8,11H2,1-2H3,(H,24,25,26,28)
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391772
PNG
(6-((7-(4-Cyano-3-(trifluoromethyl)phenyl)-5,6,7,8-...)
Show SMILES FC(F)(F)CNC(=O)c1ccc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)nn1
Show InChI InChI=1S/C22H16F6N8O/c23-21(24,25)10-30-20(37)16-3-4-18(35-34-16)33-19-14-5-6-36(9-17(14)31-11-32-19)13-2-1-12(8-29)15(7-13)22(26,27)28/h1-4,7,11H,5-6,9-10H2,(H,30,37)(H,31,32,33,35)
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391795
PNG
(4-(4-((4-Fluoro-5-(2-hydroxypropan-2-yl)pyridin-2-...)
Show SMILES CC(C)(O)c1cnc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)cc1F
Show InChI InChI=1S/C23H20F4N6O/c1-22(2,34)17-10-29-20(8-18(17)24)32-21-15-5-6-33(11-19(15)30-12-31-21)14-4-3-13(9-28)16(7-14)23(25,26)27/h3-4,7-8,10,12,34H,5-6,11H2,1-2H3,(H,29,30,31,32)
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391730
PNG
(4-(4-((1,2,4-Thiadiazol-5-yl)amino)-5,6-dihydropyr...)
Show SMILES FC(F)(F)c1cc(ccc1C#N)N1CCc2c(C1)ncnc2Nc1ncns1
Show InChI InChI=1S/C17H12F3N7S/c18-17(19,20)13-5-11(2-1-10(13)6-21)27-4-3-12-14(7-27)22-8-23-15(12)26-16-24-9-25-28-16/h1-2,5,8-9H,3-4,7H2,(H,22,23,24,25,26)
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391775
PNG
(6-((7-(4-Cyano-3-(trifluoromethyl)phenyl)-5,6,7,8-...)
Show SMILES FC(F)CNC(=O)c1ccc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)nc1
Show InChI InChI=1S/C23H18F5N7O/c24-19(25)10-31-22(36)14-2-4-20(30-9-14)34-21-16-5-6-35(11-18(16)32-12-33-21)15-3-1-13(8-29)17(7-15)23(26,27)28/h1-4,7,9,12,19H,5-6,10-11H2,(H,31,36)(H,30,32,33,34)
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391758
PNG
(4-(4-((6-(2-Hydroxypropan-2-yl)pyridazin-3-yl)amin...)
Show SMILES CC(C)(O)c1ccc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)nn1
Show InChI InChI=1S/C22H20F3N7O/c1-21(2,33)18-5-6-19(31-30-18)29-20-15-7-8-32(11-17(15)27-12-28-20)14-4-3-13(10-26)16(9-14)22(23,24)25/h3-6,9,12,33H,7-8,11H2,1-2H3,(H,27,28,29,31)
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391768
PNG
(4-(4-((5-((1,4-Oxazepan-4-yl)sulfonyl)thiazol-2-yl...)
Show SMILES FC(F)(F)c1cc(ccc1C#N)N1CCc2c(C1)ncnc2Nc1ncc(s1)S(=O)(=O)N1CCCOCC1
Show InChI InChI=1S/C23H22F3N7O3S2/c24-23(25,26)18-10-16(3-2-15(18)11-27)32-6-4-17-19(13-32)29-14-30-21(17)31-22-28-12-20(37-22)38(34,35)33-5-1-8-36-9-7-33/h2-3,10,12,14H,1,4-9,13H2,(H,28,29,30,31)
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391761
PNG
(4-(4-((6-Isopropoxypyridin-3-yl)amino)-5,6-dihydro...)
Show SMILES CC(C)Oc1ccc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)cn1
Show InChI InChI=1S/C23H21F3N6O/c1-14(2)33-21-6-4-16(11-28-21)31-22-18-7-8-32(12-20(18)29-13-30-22)17-5-3-15(10-27)19(9-17)23(24,25)26/h3-6,9,11,13-14H,7-8,12H2,1-2H3,(H,29,30,31)
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391763
PNG
(4-(4-((6-(2-(1H-1,2,3-Triazol-1-yl)ethoxy)pyridin-...)
Show SMILES FC(F)(F)c1cc(ccc1C#N)N1CCc2c(C1)ncnc2Nc1ccc(OCCn2ccnn2)nc1
Show InChI InChI=1S/C24H20F3N9O/c25-24(26,27)20-11-18(3-1-16(20)12-28)35-7-5-19-21(14-35)30-15-31-23(19)33-17-2-4-22(29-13-17)37-10-9-36-8-6-32-34-36/h1-4,6,8,11,13,15H,5,7,9-10,14H2,(H,30,31,33)
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n/an/a 130n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391767
PNG
(6-((7-(4-Cyano-3-(trifluoromethyl)phenyl)-5,6,7,8-...)
Show SMILES FC(F)(F)c1cc(ccc1C#N)N1CCc2c(C1)ncnc2Nc1ccc(cn1)S(=O)(=O)NC1CC1
Show InChI InChI=1S/C23H20F3N7O2S/c24-23(25,26)19-9-16(4-1-14(19)10-27)33-8-7-18-20(12-33)29-13-30-22(18)31-21-6-5-17(11-28-21)36(34,35)32-15-2-3-15/h1,4-6,9,11,13,15,32H,2-3,7-8,12H2,(H,28,29,30,31)
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391800
PNG
(4-(4-((5-Chloro-6-(2-methyl-2-(1H-tetrazol-1-yl)pr...)
Show SMILES CC(C)(COc1ncc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)cc1Cl)n1cnnn1
Show InChI InChI=1S/C25H22ClF3N10O/c1-24(2,39-14-34-36-37-39)12-40-23-20(26)7-16(10-31-23)35-22-18-5-6-38(11-21(18)32-13-33-22)17-4-3-15(9-30)19(8-17)25(27,28)29/h3-4,7-8,10,13-14H,5-6,11-12H2,1-2H3,(H,32,33,35)
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n/an/a 150n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391753
PNG
(4-(4-((5-(2-Hydroxypropan-2-yl)pyridin-2-yl)amino)...)
Show SMILES CC(C)(O)c1ccc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)nc1
Show InChI InChI=1S/C23H21F3N6O/c1-22(2,33)15-4-6-20(28-11-15)31-21-17-7-8-32(12-19(17)29-13-30-21)16-5-3-14(10-27)18(9-16)23(24,25)26/h3-6,9,11,13,33H,7-8,12H2,1-2H3,(H,28,29,30,31)
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n/an/a 160n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391783
PNG
(6-((7-(4-Cano-3-(trifluoromethyl)phenyl)-5,6,7,8-t...)
Show SMILES FC(F)(F)c1csc(CNC(=O)c2ccc(Nc3ncnc4CN(CCc34)c3ccc(C#N)c(c3)C(F)(F)F)nc2)n1
Show InChI InChI=1S/C26H18F6N8OS/c27-25(28,29)18-7-16(3-1-14(18)8-33)40-6-5-17-19(11-40)36-13-37-23(17)39-21-4-2-15(9-34-21)24(41)35-10-22-38-20(12-42-22)26(30,31)32/h1-4,7,9,12-13H,5-6,10-11H2,(H,35,41)(H,34,36,37,39)
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n/an/a 170n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391784
PNG
((R)—N-(1-(1,3,4-Oxadiazol-2-yl)ethyl)-2-((7-(...)
Show SMILES C[C@@H](NC(=O)c1sc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)nc1C(F)(F)F)c1nnco1
Show InChI InChI=1S/C24H17F6N9O2S/c1-11(21-38-34-10-41-21)35-20(40)17-18(24(28,29)30)36-22(42-17)37-19-14-4-5-39(8-16(14)32-9-33-19)13-3-2-12(7-31)15(6-13)23(25,26)27/h2-3,6,9-11H,4-5,8H2,1H3,(H,35,40)(H,32,33,36,37)/t11-/m1/s1
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n/an/a 170n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391760
PNG
(4-(4-((5-(1-Hydroxycyclopropyl)pyridin-2-yl)amino)...)
Show SMILES OC1(CC1)c1ccc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)nc1
Show InChI InChI=1S/C23H19F3N6O/c24-23(25,26)18-9-16(3-1-14(18)10-27)32-8-5-17-19(12-32)29-13-30-21(17)31-20-4-2-15(11-28-20)22(33)6-7-22/h1-4,9,11,13,33H,5-8,12H2,(H,28,29,30,31)
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n/an/a 170n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391765
PNG
(4-(4-((5-(2-Methyl-2-(1H-tetrazol-1-yl)propoxy)pyr...)
Show SMILES CC(C)(COc1ccc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)nc1)n1cnnn1
Show InChI InChI=1S/C25H23F3N10O/c1-24(2,38-15-33-35-36-38)13-39-18-5-6-22(30-11-18)34-23-19-7-8-37(12-21(19)31-14-32-23)17-4-3-16(10-29)20(9-17)25(26,27)28/h3-6,9,11,14-15H,7-8,12-13H2,1-2H3,(H,30,31,32,34)
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391782
PNG
(5-((7-(4-Cano-3-(trifluoromethyl)phenyl)-5,6,7,8-t...)
Show SMILES Cn1nccc1CCNC(=O)c1nnc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)s1
Show InChI InChI=1S/C24H21F3N10OS/c1-36-15(5-8-32-36)4-7-29-21(38)22-34-35-23(39-22)33-20-17-6-9-37(12-19(17)30-13-31-20)16-3-2-14(11-28)18(10-16)24(25,26)27/h2-3,5,8,10,13H,4,6-7,9,12H2,1H3,(H,29,38)(H,30,31,33,35)
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391751
PNG
(4-(4-((6-Fluoro-5-(2-hydroxypropan-2-yl)pyridin-2-...)
Show SMILES CC(C)(O)c1ccc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)nc1F
Show InChI InChI=1S/C23H20F4N6O/c1-22(2,34)16-5-6-19(31-20(16)24)32-21-15-7-8-33(11-18(15)29-12-30-21)14-4-3-13(10-28)17(9-14)23(25,26)27/h3-6,9,12,34H,7-8,11H2,1-2H3,(H,29,30,31,32)
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n/an/a 190n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391777
PNG
(6-((7-(3-Chloro-4-cyanophenyl)-5,6,7,8-tetrahydrop...)
Show SMILES O[C@H]1CC[C@@H](CC1)NC(=O)c1ccc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(Cl)c2)nn1
Show InChI InChI=1S/C25H25ClN8O2/c26-20-11-17(4-1-15(20)12-27)34-10-9-19-22(13-34)28-14-29-24(19)31-23-8-7-21(32-33-23)25(36)30-16-2-5-18(35)6-3-16/h1,4,7-8,11,14,16,18,35H,2-3,5-6,9-10,13H2,(H,30,36)(H,28,29,31,33)/t16-,18-
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391764
PNG
(4-(4-((6-(2-Methyl-2-(1H-tetrazol-1-yl)propoxy)pyr...)
Show SMILES CC(C)(COc1ccc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)cn1)n1cnnn1
Show InChI InChI=1S/C25H23F3N10O/c1-24(2,38-15-33-35-36-38)13-39-22-6-4-17(11-30-22)34-23-19-7-8-37(12-21(19)31-14-32-23)18-5-3-16(10-29)20(9-18)25(26,27)28/h3-6,9,11,14-15H,7-8,12-13H2,1-2H3,(H,31,32,34)
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391794
PNG
(2-Chloro-4-(4-((6-fluoro-5-(2-hydroxypropan-2-yl)p...)
Show SMILES CC(C)(O)c1ccc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(Cl)c2)nc1F
Show InChI InChI=1S/C22H20ClFN6O/c1-22(2,31)16-5-6-19(28-20(16)24)29-21-15-7-8-30(11-18(15)26-12-27-21)14-4-3-13(10-25)17(23)9-14/h3-6,9,12,31H,7-8,11H2,1-2H3,(H,26,27,28,29)
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391755
PNG
(2-Chloro-4-(4-((5-(2-hydroxypropan-2-yl)pyridin-2-...)
Show SMILES CC(C)(O)c1ccc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(Cl)c2)nc1
Show InChI InChI=1S/C22H21ClN6O/c1-22(2,30)15-4-6-20(25-11-15)28-21-17-7-8-29(12-19(17)26-13-27-21)16-5-3-14(10-24)18(23)9-16/h3-6,9,11,13,30H,7-8,12H2,1-2H3,(H,25,26,27,28)
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391754
PNG
(4-(4-((5-(2-Hydroxypropan-2-yl)-4-(trifluoromethyl...)
Show SMILES CC(C)(O)c1sc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)nc1C(F)(F)F
Show InChI InChI=1S/C22H18F6N6OS/c1-20(2,35)17-16(22(26,27)28)32-19(36-17)33-18-13-5-6-34(9-15(13)30-10-31-18)12-4-3-11(8-29)14(7-12)21(23,24)25/h3-4,7,10,35H,5-6,9H2,1-2H3,(H,30,31,32,33)
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391787
PNG
((R)-6-((7-(4-Cyano-3-(trifluoromethyl)phenyl)-5,6,...)
Show SMILES C[C@@H](NC(=O)c1ccc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)nc1)c1nnc(o1)C(F)(F)F
Show InChI InChI=1S/C26H19F6N9O2/c1-13(23-39-40-24(43-23)26(30,31)32)37-22(42)15-3-5-20(34-10-15)38-21-17-6-7-41(11-19(17)35-12-36-21)16-4-2-14(9-33)18(8-16)25(27,28)29/h2-5,8,10,12-13H,6-7,11H2,1H3,(H,37,42)(H,34,35,36,38)/t13-/m1/s1
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391762
PNG
(4-(4-((4-(2-(1-Methyl-1H-pyrazol-5-yl)ethoxy)pheny...)
Show SMILES Cn1nccc1CCOc1ccc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C27H24F3N7O/c1-36-20(8-11-34-36)10-13-38-22-6-3-19(4-7-22)35-26-23-9-12-37(16-25(23)32-17-33-26)21-5-2-18(15-31)24(14-21)27(28,29)30/h2-8,11,14,17H,9-10,12-13,16H2,1H3,(H,32,33,35)
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391780
PNG
(5-((7-(4-Cyano-3-(trifluoromethyl)phenyl)-5,6,7,8-...)
Show SMILES CC(C)(O)CNC(=O)c1cnc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)cn1
Show InChI InChI=1S/C24H23F3N8O2/c1-23(2,37)12-31-22(36)18-9-30-20(10-29-18)34-21-16-5-6-35(11-19(16)32-13-33-21)15-4-3-14(8-28)17(7-15)24(25,26)27/h3-4,7,9-10,13,37H,5-6,11-12H2,1-2H3,(H,31,36)(H,30,32,33,34)
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391798
PNG
(4-(4-((5-Fluoro-6-(2-methyl-2-(1H-tetrazol-1-yl)pr...)
Show SMILES CC(C)(COc1ncc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)cc1F)n1cnnn1
Show InChI InChI=1S/C25H22F4N10O/c1-24(2,39-14-34-36-37-39)12-40-23-20(26)7-16(10-31-23)35-22-18-5-6-38(11-21(18)32-13-33-22)17-4-3-15(9-30)19(8-17)25(27,28)29/h3-4,7-8,10,13-14H,5-6,11-12H2,1-2H3,(H,32,33,35)
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391766
PNG
(4-(4-((4-(3-(4-(Methylsulfonyl)piperazin-1-yl)prop...)
Show SMILES CS(=O)(=O)N1CCN(CCCOc2ccc(Nc3ncnc4CN(CCc34)c3ccc(C#N)c(c3)C(F)(F)F)cc2)CC1
Show InChI InChI=1S/C29H32F3N7O3S/c1-43(40,41)39-14-12-37(13-15-39)10-2-16-42-24-7-4-22(5-8-24)36-28-25-9-11-38(19-27(25)34-20-35-28)23-6-3-21(18-33)26(17-23)29(30,31)32/h3-8,17,20H,2,9-16,19H2,1H3,(H,34,35,36)
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TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391748
PNG
(4-(4-((4-Isopropoxyphenyl)amino)-5,6-dihydropyrido...)
Show SMILES CC(C)Oc1ccc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C24H22F3N5O/c1-15(2)33-19-7-4-17(5-8-19)31-23-20-9-10-32(13-22(20)29-14-30-23)18-6-3-16(12-28)21(11-18)24(25,26)27/h3-8,11,14-15H,9-10,13H2,1-2H3,(H,29,30,31)
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n/an/a 370n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391770
PNG
(2-(6-((7-(4-Cyano-3-(trifluoromethyl)phenyl)-5,6,7...)
Show SMILES FC(F)(F)CNC(=O)Cc1ccc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)nc1
Show InChI InChI=1S/C24H19F6N7O/c25-23(26,27)12-33-21(38)7-14-1-4-20(32-10-14)36-22-17-5-6-37(11-19(17)34-13-35-22)16-3-2-15(9-31)18(8-16)24(28,29)30/h1-4,8,10,13H,5-7,11-12H2,(H,33,38)(H,32,34,35,36)
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n/an/a 370n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391769
PNG
(2,2,2-Trifluoroethyl (6-((7-(4-cyano-3-(trifluorom...)
Show SMILES FC(F)(F)COC(=O)Nc1ccc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)nc1
Show InChI InChI=1S/C23H17F6N7O2/c24-22(25,26)11-38-21(37)34-14-2-4-19(31-9-14)35-20-16-5-6-36(10-18(16)32-12-33-20)15-3-1-13(8-30)17(7-15)23(27,28)29/h1-4,7,9,12H,5-6,10-11H2,(H,34,37)(H,31,32,33,35)
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n/an/a 380n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391778
PNG
(2-((7-(4-Cyano-3-(trifluoromethyl)phenyl)-5,6,7,8-...)
Show SMILES FC(F)(F)CNC(=O)c1ccnc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)c1
Show InChI InChI=1S/C23H17F6N7O/c24-22(25,26)11-32-21(37)13-3-5-31-19(7-13)35-20-16-4-6-36(10-18(16)33-12-34-20)15-2-1-14(9-30)17(8-15)23(27,28)29/h1-3,5,7-8,12H,4,6,10-11H2,(H,32,37)(H,31,33,34,35)
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n/an/a 390n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391796
PNG
(5-((7-(4-Cyano-3-(trifluoromethyl)phenyl)-5,6,7,8-...)
Show SMILES FC(F)CNC(=O)c1ccc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)cn1
Show InChI InChI=1S/C23H18F5N7O/c24-20(25)10-31-22(36)18-4-2-14(9-30-18)34-21-16-5-6-35(11-19(16)32-12-33-21)15-3-1-13(8-29)17(7-15)23(26,27)28/h1-4,7,9,12,20H,5-6,10-11H2,(H,31,36)(H,32,33,34)
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n/an/a 490n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391749
PNG
(4-(4-((4-Methoxyphenyl)amino)-5,6-dihydropyrido[3,...)
Show SMILES COc1ccc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C22H18F3N5O/c1-31-17-6-3-15(4-7-17)29-21-18-8-9-30(12-20(18)27-13-28-21)16-5-2-14(11-26)19(10-16)22(23,24)25/h2-7,10,13H,8-9,12H2,1H3,(H,27,28,29)
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n/an/a 530n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391785
PNG
((R)—N-(1-(1,3,4-Oxadiazol-2-yl)ethyl)-6-((7-(...)
Show SMILES C[C@@H](NC(=O)c1ccc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)nc1)c1nnco1
Show InChI InChI=1S/C25H20F3N9O2/c1-14(24-36-33-13-39-24)34-23(38)16-3-5-21(30-10-16)35-22-18-6-7-37(11-20(18)31-12-32-22)17-4-2-15(9-29)19(8-17)25(26,27)28/h2-5,8,10,12-14H,6-7,11H2,1H3,(H,34,38)(H,30,31,32,35)/t14-/m1/s1
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n/an/a 560n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391750
PNG
(4-(4-((1,1′-Biphenyl)-3-ylamino)-5,6-dihydro...)
Show SMILES FC(F)(F)c1cc(ccc1C#N)N1CCc2c(C1)ncnc2Nc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C27H20F3N5/c28-27(29,30)24-14-22(10-9-20(24)15-31)35-12-11-23-25(16-35)32-17-33-26(23)34-21-8-4-7-19(13-21)18-5-2-1-3-6-18/h1-10,13-14,17H,11-12,16H2,(H,32,33,34)
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n/an/a 620n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391781
PNG
(2-((7-(4-Cyano-3-(trifluoromethyl)phenyl)-5,6,7,8-...)
Show SMILES CC(C)(O)CNC(=O)c1cnc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)nc1
Show InChI InChI=1S/C24H23F3N8O2/c1-23(2,37)12-31-21(36)15-9-29-22(30-10-15)34-20-17-5-6-35(11-19(17)32-13-33-20)16-4-3-14(8-28)18(7-16)24(25,26)27/h3-4,7,9-10,13,37H,5-6,11-12H2,1-2H3,(H,31,36)(H,29,30,32,33,34)
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n/an/a 700n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391791
PNG
(4-(4-((5-(4-(2-Hydroxypropan-2-yl)piperidin-1-carb...)
Show SMILES CC(C)(O)C1CCN(CC1)C(=O)c1nnc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)o1
Show InChI InChI=1S/C26H27F3N8O3/c1-25(2,39)16-5-8-36(9-6-16)23(38)22-34-35-24(40-22)33-21-18-7-10-37(13-20(18)31-14-32-21)17-4-3-15(12-30)19(11-17)26(27,28)29/h3-4,11,14,16,39H,5-10,13H2,1-2H3,(H,31,32,33,35)
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n/an/a 790n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391771
PNG
(N-(6-((7-(4-Cano-3-(trifluoromethyl)phenyl)-5,6,7,...)
Show SMILES FC(F)(F)CC(=O)Nc1ccc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)nc1
Show InChI InChI=1S/C23H17F6N7O/c24-22(25,26)8-20(37)34-14-2-4-19(31-10-14)35-21-16-5-6-36(11-18(16)32-12-33-21)15-3-1-13(9-30)17(7-15)23(27,28)29/h1-4,7,10,12H,5-6,8,11H2,(H,34,37)(H,31,32,33,35)
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n/an/a 800n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391803
PNG
(2-Chloro-4-(4-((6-fluoro-5-(1-hydroxycyclobutyl)py...)
Show SMILES OC1(CCC1)c1ccc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(Cl)c2)nc1F
Show InChI InChI=1S/C23H20ClFN6O/c24-18-10-15(3-2-14(18)11-26)31-9-6-16-19(12-31)27-13-28-22(16)30-20-5-4-17(21(25)29-20)23(32)7-1-8-23/h2-5,10,13,32H,1,6-9,12H2,(H,27,28,29,30)
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n/an/a 840n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391793
PNG
(2-Chloro-4-(4-((4-fluoro-5-(2-hydroxypropan-2-yl)p...)
Show SMILES CC(C)(O)c1cnc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(Cl)c2)cc1F
Show InChI InChI=1S/C22H20ClFN6O/c1-22(2,31)16-10-26-20(8-18(16)24)29-21-15-5-6-30(11-19(15)27-12-28-21)14-4-3-13(9-25)17(23)7-14/h3-4,7-8,10,12,31H,5-6,11H2,1-2H3,(H,26,27,28,29)
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n/an/a 940n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391799
PNG
(4-(4-((5-Fluoro-6-(2-methyl-2-(1H-1,2,3-triazol-1-...)
Show SMILES CC(C)(COc1ncc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)cc1F)n1ccnn1
Show InChI InChI=1S/C26H23F4N9O/c1-25(2,39-8-6-35-37-39)14-40-24-21(27)9-17(12-32-24)36-23-19-5-7-38(13-22(19)33-15-34-23)18-4-3-16(11-31)20(10-18)26(28,29)30/h3-4,6,8-10,12,15H,5,7,13-14H2,1-2H3,(H,33,34,36)
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n/an/a 1.10E+3n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391788
PNG
(4-(4-((4-(4-(2-Hydroxypropan-2-yl)piperidin-1-carb...)
Show SMILES CC(C)(O)C1CCN(CC1)C(=O)c1coc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)n1
Show InChI InChI=1S/C27H28F3N7O3/c1-26(2,39)17-5-8-36(9-6-17)24(38)22-14-40-25(34-22)35-23-19-7-10-37(13-21(19)32-15-33-23)18-4-3-16(12-31)20(11-18)27(28,29)30/h3-4,11,14-15,17,39H,5-10,13H2,1-2H3,(H,32,33,34,35)
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n/an/a 1.94E+3n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391786
PNG
((R)—N-(1-(1,3,4-Oxadiazol-2-yl)ethyl)-5-((7-(...)
Show SMILES C[C@@H](NC(=O)c1nnc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)s1)c1nnco1
Show InChI InChI=1S/C22H17F3N10O2S/c1-11(19-32-29-10-37-19)30-18(36)20-33-34-21(38-20)31-17-14-4-5-35(8-16(14)27-9-28-17)13-3-2-12(7-26)15(6-13)22(23,24)25/h2-3,6,9-11H,4-5,8H2,1H3,(H,30,36)(H,27,28,31,34)/t11-/m1/s1
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n/an/a 2.05E+3n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (Human))
BDBM391773
PNG
(3-((7-(4-Cyano-3-(trifluoromethyl)phenyl)-5,6,7,8-...)
Show SMILES FC(F)(F)CNC(=O)c1cnc(Nc2ncnc3CN(CCc23)c2ccc(C#N)c(c2)C(F)(F)F)nn1
Show InChI InChI=1S/C21H15F6N9O/c22-20(23,24)9-30-18(37)15-7-29-19(35-34-15)33-17-13-3-4-36(8-16(13)31-10-32-17)12-2-1-11(6-28)14(5-12)21(25,26)27/h1-2,5,7,10H,3-4,8-9H2,(H,30,37)(H,29,31,32,33,35)
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n/an/a 3.32E+3n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Antagonist activity for AR was evaluated according to the following method. COS-7 cells (ATCC) were transfected with pMMTV-luc vector (reporter plasm...


US Patent US10300067 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%