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Patent code US10301269

Compile Data Set for Download or QSAR
Found 41 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391956
PNG
(1-(4-Bromophenyl)-3- [1-(1H-imidazol-2- yl)propyl]...)
Show SMILES CCC(NC(=O)Nc1ccc(Br)cc1)c1ncc[nH]1
Show InChI InChI=1/C13H15BrN4O/c1-2-11(12-15-7-8-16-12)18-13(19)17-10-5-3-9(14)4-6-10/h3-8,11H,2H2,1H3,(H,15,16)(H2,17,18,19)
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n/an/an/an/a 898n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391996
PNG
(N,N-Dimethyl-2-(2- {(1S)-2-methyl-1-[({[4- (triflu...)
Show SMILES CC(C)[C@H](NC(=O)Nc1ccc(cc1)C(F)(F)F)c1nccn1CC(=O)N(C)C
Show InChI InChI=1S/C19H24F3N5O2/c1-12(2)16(17-23-9-10-27(17)11-15(28)26(3)4)25-18(29)24-14-7-5-13(6-8-14)19(20,21)22/h5-10,12,16H,11H2,1-4H3,(H2,24,25,29)/t16-/m0/s1
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n/an/an/an/a 277n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391968
PNG
(1-(4-Bromophenyl)-3- {1-[1-(2-hydroxyethyl)- 1H-im...)
Show SMILES CC(NC(=O)Nc1ccc(Br)cc1)c1nccn1CCO
Show InChI InChI=1S/C14H17BrN4O2/c1-10(13-16-6-7-19(13)8-9-20)17-14(21)18-12-4-2-11(15)3-5-12/h2-7,10,20H,8-9H2,1H3,(H2,17,18,21)
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n/an/an/an/a 200n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391978
PNG
(Ethyl 3-[2-(1-{[(4- Bromophenyl)carbamoyl] amino}p...)
Show SMILES CCOC(=O)CCn1ccnc1C(CC)NC(=O)Nc1ccc(Br)cc1
Show InChI InChI=1S/C18H23BrN4O3/c1-3-15(22-18(25)21-14-7-5-13(19)6-8-14)17-20-10-12-23(17)11-9-16(24)26-4-2/h5-8,10,12,15H,3-4,9,11H2,1-2H3,(H2,21,22,25)
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n/an/an/an/a 1.21E+3n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391980
PNG
(Ethyl 3-{2-[1-({[4- (trifluoromethyl)phenyl] carba...)
Show SMILES CCOC(=O)CCn1ccnc1C(CC)NC(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H23F3N4O3/c1-3-15(17-23-10-12-26(17)11-9-16(27)29-4-2)25-18(28)24-14-7-5-13(6-8-14)19(20,21)22/h5-8,10,12,15H,3-4,9,11H2,1-2H3,(H2,24,25,28)
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n/an/an/an/a 1.11E+3n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391992
PNG
(US10301269, Number 38 | {2-[(1S)-1-({[(4-bromo- 2-...)
Show SMILES CC(C)[C@H](NC(=O)Nc1ccc(Br)cc1F)c1nccn1CC(O)=O
Show InChI InChI=1S/C16H18BrFN4O3/c1-9(2)14(15-19-5-6-22(15)8-13(23)24)21-16(25)20-12-4-3-10(17)7-11(12)18/h3-7,9,14H,8H2,1-2H3,(H,23,24)(H2,20,21,25)/t14-/m0/s1
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n/an/an/an/a 14n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391994
PNG
(2-(2-{(1S)-2-methyl-1- [({[4-(trifluoromethyl) phe...)
Show SMILES CC(C)[C@H](NC(=O)Nc1ccc(cc1)C(F)(F)F)c1nccn1CC(N)=O
Show InChI InChI=1S/C17H20F3N5O2/c1-10(2)14(15-22-7-8-25(15)9-13(21)26)24-16(27)23-12-5-3-11(4-6-12)17(18,19)20/h3-8,10,14H,9H2,1-2H3,(H2,21,26)(H2,23,24,27)/t14-/m0/s1
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n/an/an/an/a 43n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391962
PNG
(Ethyl [2-(1-{[(4- Bromophenyl)carbamoyl] amino}pro...)
Show SMILES CCOC(=O)Cn1ccnc1C(CC)NC(=O)Nc1ccc(Br)cc1
Show InChI InChI=1S/C17H21BrN4O3/c1-3-14(16-19-9-10-22(16)11-15(23)25-4-2)21-17(24)20-13-7-5-12(18)6-8-13/h5-10,14H,3-4,11H2,1-2H3,(H2,20,21,24)
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n/an/an/an/a 439n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391964
PNG
(US10301269, Number 9 | tert-Butyl {2-[(1S)-1- {[(4...)
Show SMILES CCC[C@H](NC(=O)Nc1ccc(Br)cc1)c1nccn1CC(=O)OC(C)(C)C
Show InChI InChI=1S/C20H27BrN4O3/c1-5-6-16(24-19(27)23-15-9-7-14(21)8-10-15)18-22-11-12-25(18)13-17(26)28-20(2,3)4/h7-12,16H,5-6,13H2,1-4H3,(H2,23,24,27)/t16-/m0/s1
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n/an/an/an/a 1.29E+3n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391969
PNG
(Ethyl 2-[2-({[(4- Bromophenyl)carbamoyl] amino}met...)
Show SMILES CCOC(=O)C(C)n1ccnc1CNC(=O)Nc1ccc(Br)cc1
Show InChI InChI=1S/C16H19BrN4O3/c1-3-24-15(22)11(2)21-9-8-18-14(21)10-19-16(23)20-13-6-4-12(17)5-7-13/h4-9,11H,3,10H2,1-2H3,(H2,19,20,23)
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n/an/an/an/a 584n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391971
PNG
(US10301269, Number 16 | [2-(1-{[(4- Bromophenyl)ca...)
Show SMILES CCC(NC(=O)Nc1ccc(Br)cc1)c1nccn1CC(O)=O
Show InChI InChI=1S/C15H17BrN4O3/c1-2-12(14-17-7-8-20(14)9-13(21)22)19-15(23)18-11-5-3-10(16)4-6-11/h3-8,12H,2,9H2,1H3,(H,21,22)(H2,18,19,23)
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n/an/an/an/a 47n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391972
PNG
(US10301269, Number 17 | [2-({[(4- Bromophenyl)carb...)
Show SMILES OC(=O)Cn1ccnc1CNC(=O)Nc1ccc(Br)cc1
Show InChI InChI=1S/C13H13BrN4O3/c14-9-1-3-10(4-2-9)17-13(21)16-7-11-15-5-6-18(11)8-12(19)20/h1-6H,7-8H2,(H,19,20)(H2,16,17,21)
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n/an/an/an/a 3.28E+3n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391966
PNG
(Ethyl [2-({[(4- Bromophenyl)carbamoyl] amino}methy...)
Show SMILES CCOC(=O)Cn1ccnc1CNC(=O)Nc1ccc(Br)cc1
Show InChI InChI=1S/C15H17BrN4O3/c1-2-23-14(21)10-20-8-7-17-13(20)9-18-15(22)19-12-5-3-11(16)4-6-12/h3-8H,2,9-10H2,1H3,(H2,18,19,22)
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n/an/an/an/a 400n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391991
PNG
(US10301269, Number 37 | {2-[(1S)-1-({[(4- Chloroph...)
Show SMILES CC(C)[C@H](NC(=O)Nc1ccc(Cl)cc1)c1nccn1CC(O)=O
Show InChI InChI=1S/C16H19ClN4O3/c1-10(2)14(15-18-7-8-21(15)9-13(22)23)20-16(24)19-12-5-3-11(17)4-6-12/h3-8,10,14H,9H2,1-2H3,(H,22,23)(H2,19,20,24)/t14-/m0/s1
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n/an/an/an/a 40n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391995
PNG
(2-(2-{(1S)-2-methyl-1- [({[4-(trifluoromethyl) phe...)
Show SMILES CCCNC(=O)Cn1ccnc1[C@@H](NC(=O)Nc1ccc(cc1)C(F)(F)F)C(C)C
Show InChI InChI=1S/C20H26F3N5O2/c1-4-9-24-16(29)12-28-11-10-25-18(28)17(13(2)3)27-19(30)26-15-7-5-14(6-8-15)20(21,22)23/h5-8,10-11,13,17H,4,9,12H2,1-3H3,(H,24,29)(H2,26,27,30)/t17-/m0/s1
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n/an/an/an/a 206n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391977
PNG
(3-{2-[1-({[4- (Trifluoromethyl)phenyl] carbamoyl}a...)
Show SMILES CCC(NC(=O)Nc1ccc(cc1)C(F)(F)F)c1nccn1CCC(O)=O
Show InChI InChI=1S/C17H19F3N4O3/c1-2-13(15-21-8-10-24(15)9-7-14(25)26)23-16(27)22-12-5-3-11(4-6-12)17(18,19)20/h3-6,8,10,13H,2,7,9H2,1H3,(H,25,26)(H2,22,23,27)
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n/an/an/an/a 23n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391981
PNG
(US10301269, Number 26 | {2-[(1S)-1-{[(4- Bromophen...)
Show SMILES CCC[C@H](NC(=O)Nc1ccc(Br)cc1)c1nccn1CC(O)=O
Show InChI InChI=1S/C16H19BrN4O3/c1-2-3-13(15-18-8-9-21(15)10-14(22)23)20-16(24)19-12-6-4-11(17)5-7-12/h4-9,13H,2-3,10H2,1H3,(H,22,23)(H2,19,20,24)/t13-/m0/s1
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n/an/an/an/a 173n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391985
PNG
(1-(4-Bromo-2- fluorophenyl)-3-[(1S)-1- (1H-imidazo...)
Show SMILES CC(C)[C@H](NC(=O)Nc1ccc(Br)cc1F)c1ncc[nH]1
Show InChI InChI=1/C14H16BrFN4O/c1-8(2)12(13-17-5-6-18-13)20-14(21)19-11-4-3-9(15)7-10(11)16/h3-8,12H,1-2H3,(H,17,18)(H2,19,20,21)/t12-/s2
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n/an/an/an/a 8n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391988
PNG
(US10301269, Number 34 | tert-Butyl {2-[(1S)-1- ({[...)
Show SMILES CC(C)[C@H](NC(=O)Nc1ccc(Br)cc1F)c1nccn1CC(=O)OC(C)(C)C
Show InChI InChI=1S/C20H26BrFN4O3/c1-12(2)17(25-19(28)24-15-7-6-13(21)10-14(15)22)18-23-8-9-26(18)11-16(27)29-20(3,4)5/h6-10,12,17H,11H2,1-5H3,(H2,24,25,28)/t17-/m0/s1
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n/an/an/an/a 855n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391990
PNG
((2-{(1S)-2-Methyl-1- [({[4- (trifluoromethyl)pheny...)
Show SMILES CC(C)[C@H](NC(=O)Nc1ccc(cc1)C(F)(F)F)c1nccn1CC(O)=O
Show InChI InChI=1S/C17H19F3N4O3/c1-10(2)14(15-21-7-8-24(15)9-13(25)26)23-16(27)22-12-5-3-11(4-6-12)17(18,19)20/h3-8,10,14H,9H2,1-2H3,(H,25,26)(H2,22,23,27)/t14-/m0/s1
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n/an/an/an/a 3n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391960
PNG
(1-(4-Bromophenyl)-3- [1-(1H-imidazol-2- yl)ethyl]u...)
Show SMILES CC(NC(=O)Nc1ccc(Br)cc1)c1ncc[nH]1
Show InChI InChI=1/C12H13BrN4O/c1-8(11-14-6-7-15-11)16-12(18)17-10-4-2-9(13)3-5-10/h2-8H,1H3,(H,14,15)(H2,16,17,18)
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n/an/an/an/a 401n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391970
PNG
(Ethyl {2-[1-({[4- (trifluoromethyl)phenyl] carbamo...)
Show SMILES CCOC(=O)Cn1ccnc1C(CC)NC(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C18H21F3N4O3/c1-3-14(16-22-9-10-25(16)11-15(26)28-4-2)24-17(27)23-13-7-5-12(6-8-13)18(19,20)21/h5-10,14H,3-4,11H2,1-2H3,(H2,23,24,27)
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n/an/an/an/a 332n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391974
PNG
(2-[2-({[(4- Bromophenyl)carbamoyl] amino}methyl)-1...)
Show SMILES CC(C(O)=O)n1ccnc1CNC(=O)Nc1ccc(Br)cc1
Show InChI InChI=1S/C14H15BrN4O3/c1-9(13(20)21)19-7-6-16-12(19)8-17-14(22)18-11-4-2-10(15)3-5-11/h2-7,9H,8H2,1H3,(H,20,21)(H2,17,18,22)
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US Patent
n/an/an/an/a 270n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391979
PNG
(Ethyl 3-[2-(1-{[(4- Bromophenyl)carbamoyl] amino}e...)
Show SMILES CCOC(=O)CCn1ccnc1C(C)NC(=O)Nc1ccc(Br)cc1
Show InChI InChI=1S/C17H21BrN4O3/c1-3-25-15(23)8-10-22-11-9-19-16(22)12(2)20-17(24)21-14-6-4-13(18)5-7-14/h4-7,9,11-12H,3,8,10H2,1-2H3,(H2,20,21,24)
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US Patent
n/an/an/an/a 734n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391957
PNG
(1-(4-Bromophenyl)-3- [(1S)-1-(1H-imidazol-2- yl)bu...)
Show SMILES CCC[C@H](NC(=O)Nc1ccc(Br)cc1)c1ncc[nH]1
Show InChI InChI=1/C14H17BrN4O/c1-2-3-12(13-16-8-9-17-13)19-14(20)18-11-6-4-10(15)5-7-11/h4-9,12H,2-3H2,1H3,(H,16,17)(H2,18,19,20)/t12-/s2
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US Patent
n/an/an/an/a 2.07E+3n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391973
PNG
(US10301269, Number 18 | [2-(1-{[(4- Bromophenyl)ca...)
Show SMILES CC(NC(=O)Nc1ccc(Br)cc1)c1nccn1CC(O)=O
Show InChI InChI=1S/C14H15BrN4O3/c1-9(13-16-6-7-19(13)8-12(20)21)17-14(22)18-11-4-2-10(15)3-5-11/h2-7,9H,8H2,1H3,(H,20,21)(H2,17,18,22)
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US Patent
n/an/an/an/a 30n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391975
PNG
(3-[2-(1-{[(4- Bromophenyl)carbamoyl] amino}propyl)...)
Show SMILES CCC(NC(=O)Nc1ccc(Br)cc1)c1nccn1CCC(O)=O
Show InChI InChI=1S/C16H19BrN4O3/c1-2-13(15-18-8-10-21(15)9-7-14(22)23)20-16(24)19-12-5-3-11(17)4-6-12/h3-6,8,10,13H,2,7,9H2,1H3,(H,22,23)(H2,19,20,24)
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n/an/an/an/a 42n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391982
PNG
(US10301269, Number 27 | {2-[(1S)-1-{[(4- Bromophen...)
Show SMILES CC(C)[C@H](NC(=O)Nc1ccc(Br)cc1)c1nccn1CC(O)=O
Show InChI InChI=1S/C16H19BrN4O3/c1-10(2)14(15-18-7-8-21(15)9-13(22)23)20-16(24)19-12-5-3-11(17)4-6-12/h3-8,10,14H,9H2,1-2H3,(H,22,23)(H2,19,20,24)/t14-/m0/s1
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n/an/an/an/a 46n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391986
PNG
(1-[(1S)-1-(1H-imidazol- 2-yl)-2-methylpropyl]- 3-(...)
Show SMILES COc1ccc(NC(=O)N[C@@H](C(C)C)c2ncc[nH]2)cc1
Show InChI InChI=1/C15H20N4O2/c1-10(2)13(14-16-8-9-17-14)19-15(20)18-11-4-6-12(21-3)7-5-11/h4-10,13H,1-3H3,(H,16,17)(H2,18,19,20)/t13-/s2
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n/an/an/an/a 109n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391989
PNG
(US10301269, Number 35 | tert-Butyl {2-[(1S)-1- ({[...)
Show SMILES COc1ccc(NC(=O)N[C@@H](C(C)C)c2nccn2CC(=O)OC(C)(C)C)cc1
Show InChI InChI=1S/C21H30N4O4/c1-14(2)18(24-20(27)23-15-7-9-16(28-6)10-8-15)19-22-11-12-25(19)13-17(26)29-21(3,4)5/h7-12,14,18H,13H2,1-6H3,(H2,23,24,27)/t18-/m0/s1
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n/an/an/an/a 139n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391958
PNG
(1-(4-Bromophenyl)-3- [(1S)-1-(1H-imidazol-2- yl)-2...)
Show SMILES CC(C)[C@H](NC(=O)Nc1ccc(Br)cc1)c1ncc[nH]1
Show InChI InChI=1/C14H17BrN4O/c1-9(2)12(13-16-7-8-17-13)19-14(20)18-11-5-3-10(15)4-6-11/h3-9,12H,1-2H3,(H,16,17)(H2,18,19,20)/t12-/s2
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n/an/an/an/a 46n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391959
PNG
(1-(4-Bromophenyl)-3- (1H-imidazol-2- ylmethyl)urea...)
Show SMILES Brc1ccc(NC(=O)NCc2ncc[nH]2)cc1
Show InChI InChI=1S/C11H11BrN4O/c12-8-1-3-9(4-2-8)16-11(17)15-7-10-13-5-6-14-10/h1-6H,7H2,(H,13,14)(H2,15,16,17)
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n/an/an/an/a 175n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391961
PNG
(1-[1-(1H-Imidazol-2- yl)propyl]-3-[4- (trifluorome...)
Show SMILES CCC(NC(=O)Nc1ccc(cc1)C(F)(F)F)c1ncc[nH]1
Show InChI InChI=1/C14H15F3N4O/c1-2-11(12-18-7-8-19-12)21-13(22)20-10-5-3-9(4-6-10)14(15,16)17/h3-8,11H,2H2,1H3,(H,18,19)(H2,20,21,22)
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n/an/an/an/a 199n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391965
PNG
(US10301269, Number 10 | tert-Butyl {2-[(1S)-1- {[(...)
Show SMILES CC(C)[C@H](NC(=O)Nc1ccc(Br)cc1)c1nccn1CC(=O)OC(C)(C)C
Show InChI InChI=1S/C20H27BrN4O3/c1-13(2)17(24-19(27)23-15-8-6-14(21)7-9-15)18-22-10-11-25(18)12-16(26)28-20(3,4)5/h6-11,13,17H,12H2,1-5H3,(H2,23,24,27)/t17-/m0/s1
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n/an/an/an/a 1.11E+3n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391967
PNG
(Ethyl [2-(1-{[(4- Bromophenyl)carbamoyl] amino}eth...)
Show SMILES CCOC(=O)Cn1ccnc1C(C)NC(=O)Nc1ccc(Br)cc1
Show InChI InChI=1S/C16H19BrN4O3/c1-3-24-14(22)10-21-9-8-18-15(21)11(2)19-16(23)20-13-6-4-12(17)5-7-13/h4-9,11H,3,10H2,1-2H3,(H2,19,20,23)
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n/an/an/an/a>2.00E+3n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391976
PNG
(US10301269, Number 21 | {2-[1-({[4- (Trifluorometh...)
Show SMILES CCC(NC(=O)Nc1ccc(cc1)C(F)(F)F)c1nccn1CC(O)=O
Show InChI InChI=1S/C16H17F3N4O3/c1-2-12(14-20-7-8-23(14)9-13(24)25)22-15(26)21-11-5-3-10(4-6-11)16(17,18)19/h3-8,12H,2,9H2,1H3,(H,24,25)(H2,21,22,26)
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n/an/an/an/a 6.60n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391987
PNG
(US10301269, Number 33 | tert-Butyl {2-[(1S)-1- ({[...)
Show SMILES CC(C)[C@H](NC(=O)Nc1ccc(Cl)cc1)c1nccn1CC(=O)OC(C)(C)C
Show InChI InChI=1S/C20H27ClN4O3/c1-13(2)17(24-19(27)23-15-8-6-14(21)7-9-15)18-22-10-11-25(18)12-16(26)28-20(3,4)5/h6-11,13,17H,12H2,1-5H3,(H2,23,24,27)/t17-/m0/s1
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n/an/an/an/a 361n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391993
PNG
(US10301269, Number 39 | {2-[(1S)-1-({[(4- methoxyp...)
Show SMILES COc1ccc(NC(=O)N[C@@H](C(C)C)c2nccn2CC(O)=O)cc1
Show InChI InChI=1S/C17H22N4O4/c1-11(2)15(16-18-8-9-21(16)10-14(22)23)20-17(24)19-12-4-6-13(25-3)7-5-12/h4-9,11,15H,10H2,1-3H3,(H,22,23)(H2,19,20,24)/t15-/m0/s1
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n/an/an/an/a 106n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391983
PNG
(1-[(1S)-1-(1H-imidazol- 2-yl)-2-methylpropyl]- 3-[...)
Show SMILES CC(C)[C@H](NC(=O)Nc1ccc(cc1)C(F)(F)F)c1ncc[nH]1
Show InChI InChI=1/C15H17F3N4O/c1-9(2)12(13-19-7-8-20-13)22-14(23)21-11-5-3-10(4-6-11)15(16,17)18/h3-9,12H,1-2H3,(H,19,20)(H2,21,22,23)/t12-/s2
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n/an/an/an/a 4n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391984
PNG
(1-(4-Chlorophenyl)-3- [(1S)-1-(1H-imidazol-2- yl)-...)
Show SMILES CC(C)[C@H](NC(=O)Nc1ccc(Cl)cc1)c1ncc[nH]1
Show InChI InChI=1/C14H17ClN4O/c1-9(2)12(13-16-7-8-17-13)19-14(20)18-11-5-3-10(15)4-6-11/h3-9,12H,1-2H3,(H,16,17)(H2,18,19,20)/t12-/s2
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n/an/an/an/a 9n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM391963
PNG
(Ethyl {2-[(1S)-1-{[(4- bromophenyl)carbamoyl] amin...)
Show SMILES CCC[C@H](NC(=O)Nc1ccc(Br)cc1)c1nccn1CC(=O)OCC
Show InChI InChI=1S/C18H23BrN4O3/c1-3-5-15(17-20-10-11-23(17)12-16(24)26-4-2)22-18(25)21-14-8-6-13(19)7-9-14/h6-11,15H,3-5,12H2,1-2H3,(H2,21,22,25)/t15-/m0/s1
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n/an/an/an/a 1.09E+3n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biological activity of compounds according to Formula I is set forth in Table 7 below. CHO-Gα16 cells stably expressing FPR2 were cultured in (F...


US Patent US10301269 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%