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Patent code US10301272

Compile Data Set for Download or QSAR

Found 844 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392065
PNG
(US10301272, Example 6/63)
Show SMILES Cc1c(Cl)c(c(Cl)cc1-c1sc(nc1CC1CCCCC1)C(=O)NC1CCS(=O)(=O)CC1)S(=O)(=O)NC(C)(C)C
Show InChI InChI=1S/C27H37Cl2N3O5S3/c1-16-19(15-20(28)24(22(16)29)40(36,37)32-27(2,3)4)23-21(14-17-8-6-5-7-9-17)31-26(38-23)25(33)30-18-10-12-39(34,35)13-11-18/h15,17-18,32H,5-14H2,1-4H3,(H,30,33)
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n/an/a 0.631n/an/an/an/an/an/a



Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before firefly (FF) luciferase activities were measured sequentially in the same cell extract using a Dual-L...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392031
PNG
(US10301272, Example 6/29)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)NCC(C)(C)O)c(Cl)c1Cl
Show InChI InChI=1S/C25H35Cl2N3O4S2/c1-24(2,3)30-36(33,34)18-12-11-16(19(26)20(18)27)21-17(13-15-9-7-6-8-10-15)29-23(35-21)22(31)28-14-25(4,5)32/h11-12,15,30,32H,6-10,13-14H2,1-5H3,(H,28,31)
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n/an/a 1n/an/an/an/an/an/a



Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392075
PNG
(US10301272, Example 7/8)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)N[C@H]2C[C@@H](C2)C(O)=O)c2CCCCc12
Show InChI InChI=1S/C30H41N3O5S2/c1-30(2,3)33-40(37,38)25-14-13-23(21-11-7-8-12-22(21)25)26-24(15-18-9-5-4-6-10-18)32-28(39-26)27(34)31-20-16-19(17-20)29(35)36/h13-14,18-20,33H,4-12,15-17H2,1-3H3,(H,31,34)(H,35,36)/t19-,20-
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n/an/a 1n/an/an/an/an/an/a



Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392013
PNG
(US10301272, Example 6/11)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)NC2CCOCC2)c2ccccc12
Show InChI InChI=1S/C30H39N3O4S2/c1-30(2,3)33-39(35,36)26-14-13-24(22-11-7-8-12-23(22)26)27-25(19-20-9-5-4-6-10-20)32-29(38-27)28(34)31-21-15-17-37-18-16-21/h7-8,11-14,20-21,33H,4-6,9-10,15-19H2,1-3H3,(H,31,34)
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392013
PNG
(US10301272, Example 6/11)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)NC2CCOCC2)c2ccccc12
Show InChI InChI=1S/C30H39N3O4S2/c1-30(2,3)33-39(35,36)26-14-13-24(22-11-7-8-12-23(22)26)27-25(19-20-9-5-4-6-10-20)32-29(38-27)28(34)31-21-15-17-37-18-16-21/h7-8,11-14,20-21,33H,4-6,9-10,15-19H2,1-3H3,(H,31,34)
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n/an/a 1n/an/an/an/an/an/a



Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before firefly (FF) luciferase activities were measured sequentially in the same cell extract using a Dual-L...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392066
PNG
(US10301272, Example 6/64)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)NCC(C)(C)C(N)=O)c2ccccc12
Show InChI InChI=1S/C30H40N4O4S2/c1-29(2,3)34-40(37,38)24-16-15-22(20-13-9-10-14-21(20)24)25-23(17-19-11-7-6-8-12-19)33-27(39-25)26(35)32-18-30(4,5)28(31)36/h9-10,13-16,19,34H,6-8,11-12,17-18H2,1-5H3,(H2,31,36)(H,32,35)
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n/an/a 1n/an/an/an/an/an/a



Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392202
PNG
(US10301272, Example 25/2)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2nc(sc2CC2CCCCC2)C(=O)NC2CCS(=O)(=O)CC2)c2ccccc12
Show InChI InChI=1S/C30H39N3O5S3/c1-30(2,3)33-41(37,38)26-14-13-24(22-11-7-8-12-23(22)26)27-25(19-20-9-5-4-6-10-20)39-29(32-27)28(34)31-21-15-17-40(35,36)18-16-21/h7-8,11-14,20-21,33H,4-6,9-10,15-19H2,1-3H3,(H,31,34)
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392075
PNG
(US10301272, Example 7/8)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)N[C@H]2C[C@@H](C2)C(O)=O)c2CCCCc12
Show InChI InChI=1S/C30H41N3O5S2/c1-30(2,3)33-40(37,38)25-14-13-23(21-11-7-8-12-22(21)25)26-24(15-18-9-5-4-6-10-18)32-28(39-26)27(34)31-20-16-19(17-20)29(35)36/h13-14,18-20,33H,4-12,15-17H2,1-3H3,(H,31,34)(H,35,36)/t19-,20-
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n/an/a 1n/an/an/an/an/an/a



Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before firefly (FF) luciferase activities were measured sequentially in the same cell extract using a Dual-L...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM50044179
PNG
(CHEMBL3314002 | US10301272, Example 7/4)
Show SMILES CCC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)N[C@H]2C[C@@H](C2)C(O)=O)c(Cl)c1C
Show InChI InChI=1/C28H38ClN3O5S2/c1-5-28(3,4)32-39(36,37)22-12-11-20(23(29)16(22)2)24-21(13-17-9-7-6-8-10-17)31-26(38-24)25(33)30-19-14-18(15-19)27(34)35/h11-12,17-19,32H,5-10,13-15H2,1-4H3,(H,30,33)(H,34,35)/t18-,19-
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before firefly (FF) luciferase activities were measured sequentially in the same cell extract using a Dual-L...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392202
PNG
(US10301272, Example 25/2)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2nc(sc2CC2CCCCC2)C(=O)NC2CCS(=O)(=O)CC2)c2ccccc12
Show InChI InChI=1S/C30H39N3O5S3/c1-30(2,3)33-41(37,38)26-14-13-24(22-11-7-8-12-23(22)26)27-25(19-20-9-5-4-6-10-20)39-29(32-27)28(34)31-21-15-17-40(35,36)18-16-21/h7-8,11-14,20-21,33H,4-6,9-10,15-19H2,1-3H3,(H,31,34)
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before firefly (FF) luciferase activities were measured sequentially in the same cell extract using a Dual-L...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392142
PNG
(US10301272, Example 15/4)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)NC2CS(=O)(=O)C2)c(Cl)c1Cl
Show InChI InChI=1S/C24H31Cl2N3O5S3/c1-24(2,3)29-37(33,34)18-10-9-16(19(25)20(18)26)21-17(11-14-7-5-4-6-8-14)28-23(35-21)22(30)27-15-12-36(31,32)13-15/h9-10,14-15,29H,4-8,11-13H2,1-3H3,(H,27,30)
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n/an/a 1n/an/an/an/an/an/a



Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392106
PNG
(US10301272, Example 8/11)
Show SMILES CC(NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCC2)C(=O)NC2CCS(=O)(=O)CC2)c2ccccc12)C(F)(F)F
Show InChI InChI=1S/C28H32F3N3O5S3/c1-17(28(29,30)31)34-42(38,39)24-11-10-22(20-8-4-5-9-21(20)24)25-23(16-18-6-2-3-7-18)33-27(40-25)26(35)32-19-12-14-41(36,37)15-13-19/h4-5,8-11,17-19,34H,2-3,6-7,12-16H2,1H3,(H,32,35)
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before firefly (FF) luciferase activities were measured sequentially in the same cell extract using a Dual-L...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392136
PNG
(US10301272, Example 14/6)
Show SMILES CCC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)N[C@H]2C[C@@H](C2)C(O)=O)c2ccccc12
Show InChI InChI=1S/C31H39N3O5S2/c1-4-31(2,3)34-41(38,39)26-15-14-24(22-12-8-9-13-23(22)26)27-25(16-19-10-6-5-7-11-19)33-29(40-27)28(35)32-21-17-20(18-21)30(36)37/h8-9,12-15,19-21,34H,4-7,10-11,16-18H2,1-3H3,(H,32,35)(H,36,37)/t20-,21-
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before firefly (FF) luciferase activities were measured sequentially in the same cell extract using a Dual-L...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392008
PNG
(US10301272, Example 6/6)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)NC2CCS(=O)(=O)CC2)c2ccccc12
Show InChI InChI=1S/C30H39N3O5S3/c1-30(2,3)33-41(37,38)26-14-13-24(22-11-7-8-12-23(22)26)27-25(19-20-9-5-4-6-10-20)32-29(39-27)28(34)31-21-15-17-40(35,36)18-16-21/h7-8,11-14,20-21,33H,4-6,9-10,15-19H2,1-3H3,(H,31,34)
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before firefly (FF) luciferase activities were measured sequentially in the same cell extract using a Dual-L...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392102
PNG
(US10301272, Example 8/7)
Show SMILES C[C@H](NC(=O)c1cc(cc(c1)C1(C)CC1)-c1sc(nc1CC1CCCCC1)C(=O)N[C@H]1C[C@@H](C1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C30H36F3N3O4S/c1-16(30(31,32)33)34-25(37)19-11-18(12-21(13-19)29(2)8-9-29)24-23(10-17-6-4-3-5-7-17)36-27(41-24)26(38)35-22-14-20(15-22)28(39)40/h11-13,16-17,20,22H,3-10,14-15H2,1-2H3,(H,34,37)(H,35,38)(H,39,40)/t16-,20-,22-/m0/s1
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392008
PNG
(US10301272, Example 6/6)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)NC2CCS(=O)(=O)CC2)c2ccccc12
Show InChI InChI=1S/C30H39N3O5S3/c1-30(2,3)33-41(37,38)26-14-13-24(22-11-7-8-12-23(22)26)27-25(19-20-9-5-4-6-10-20)32-29(39-27)28(34)31-21-15-17-40(35,36)18-16-21/h7-8,11-14,20-21,33H,4-6,9-10,15-19H2,1-3H3,(H,31,34)
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM50044179
PNG
(CHEMBL3314002 | US10301272, Example 7/4)
Show SMILES CCC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)N[C@H]2C[C@@H](C2)C(O)=O)c(Cl)c1C
Show InChI InChI=1/C28H38ClN3O5S2/c1-5-28(3,4)32-39(36,37)22-12-11-20(23(29)16(22)2)24-21(13-17-9-7-6-8-10-17)31-26(38-24)25(33)30-19-14-18(15-19)27(34)35/h11-12,17-19,32H,5-10,13-15H2,1-4H3,(H,30,33)(H,34,35)/t18-,19-
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392136
PNG
(US10301272, Example 14/6)
Show SMILES CCC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)N[C@H]2C[C@@H](C2)C(O)=O)c2ccccc12
Show InChI InChI=1S/C31H39N3O5S2/c1-4-31(2,3)34-41(38,39)26-15-14-24(22-12-8-9-13-23(22)26)27-25(16-19-10-6-5-7-11-19)33-29(40-27)28(35)32-21-17-20(18-21)30(36)37/h8-9,12-15,19-21,34H,4-7,10-11,16-18H2,1-3H3,(H,32,35)(H,36,37)/t20-,21-
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392031
PNG
(US10301272, Example 6/29)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)NCC(C)(C)O)c(Cl)c1Cl
Show InChI InChI=1S/C25H35Cl2N3O4S2/c1-24(2,3)30-36(33,34)18-12-11-16(19(26)20(18)27)21-17(13-15-9-7-6-8-10-15)29-23(35-21)22(31)28-14-25(4,5)32/h11-12,15,30,32H,6-10,13-14H2,1-5H3,(H,28,31)
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n/an/a 1n/an/an/an/an/an/a



Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before firefly (FF) luciferase activities were measured sequentially in the same cell extract using a Dual-L...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392076
PNG
(US10301272, Example 7/9)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)N[C@H]2C[C@@H](C2)C(O)=O)c2ccccc12
Show InChI InChI=1S/C30H37N3O5S2/c1-30(2,3)33-40(37,38)25-14-13-23(21-11-7-8-12-22(21)25)26-24(15-18-9-5-4-6-10-18)32-28(39-26)27(34)31-20-16-19(17-20)29(35)36/h7-8,11-14,18-20,33H,4-6,9-10,15-17H2,1-3H3,(H,31,34)(H,35,36)/t19-,20-
PDB

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n/an/a 1n/an/an/an/an/an/a



Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392106
PNG
(US10301272, Example 8/11)
Show SMILES CC(NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCC2)C(=O)NC2CCS(=O)(=O)CC2)c2ccccc12)C(F)(F)F
Show InChI InChI=1S/C28H32F3N3O5S3/c1-17(28(29,30)31)34-42(38,39)24-11-10-22(20-8-4-5-9-21(20)24)25-23(16-18-6-2-3-7-18)33-27(40-25)26(35)32-19-12-14-41(36,37)15-13-19/h4-5,8-11,17-19,34H,2-3,6-7,12-16H2,1H3,(H,32,35)
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392168
PNG
(US10301272, Example 20 | trans-3-(4-(Cyclohexylmet...)
Show SMILES CC(C)(CCF)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)N[C@H]2C[C@@H](C2)C(O)=O)c2ccccc12
Show InChI InChI=1S/C31H38FN3O5S2/c1-31(2,14-15-32)35-42(39,40)26-13-12-24(22-10-6-7-11-23(22)26)27-25(16-19-8-4-3-5-9-19)34-29(41-27)28(36)33-21-17-20(18-21)30(37)38/h6-7,10-13,19-21,35H,3-5,8-9,14-18H2,1-2H3,(H,33,36)(H,37,38)/t20-,21-
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392107
PNG
(US10301272, Example 8/12)
Show SMILES CC(NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCC2)C(=O)NC2CCS(=O)(=O)CC2)c(Cl)c1Cl)C(F)(F)F
Show InChI InChI=1S/C24H28Cl2F3N3O5S3/c1-13(24(27,28)29)32-40(36,37)18-7-6-16(19(25)20(18)26)21-17(12-14-4-2-3-5-14)31-23(38-21)22(33)30-15-8-10-39(34,35)11-9-15/h6-7,13-15,32H,2-5,8-12H2,1H3,(H,30,33)
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392201
PNG
(US10301272, Example 25/1)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2nc(sc2CC2CCCCC2)C(=O)N[C@H]2C[C@@H](C2)C(O)=O)c2ccccc12
Show InChI InChI=1S/C30H37N3O5S2/c1-30(2,3)33-40(37,38)25-14-13-23(21-11-7-8-12-22(21)25)26-24(15-18-9-5-4-6-10-18)39-28(32-26)27(34)31-20-16-19(17-20)29(35)36/h7-8,11-14,18-20,33H,4-6,9-10,15-17H2,1-3H3,(H,31,34)(H,35,36)/t19-,20-
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before firefly (FF) luciferase activities were measured sequentially in the same cell extract using a Dual-L...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392107
PNG
(US10301272, Example 8/12)
Show SMILES CC(NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCC2)C(=O)NC2CCS(=O)(=O)CC2)c(Cl)c1Cl)C(F)(F)F
Show InChI InChI=1S/C24H28Cl2F3N3O5S3/c1-13(24(27,28)29)32-40(36,37)18-7-6-16(19(25)20(18)26)21-17(12-14-4-2-3-5-14)31-23(38-21)22(33)30-15-8-10-39(34,35)11-9-15/h6-7,13-15,32H,2-5,8-12H2,1H3,(H,30,33)
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before firefly (FF) luciferase activities were measured sequentially in the same cell extract using a Dual-L...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392065
PNG
(US10301272, Example 6/63)
Show SMILES Cc1c(Cl)c(c(Cl)cc1-c1sc(nc1CC1CCCCC1)C(=O)NC1CCS(=O)(=O)CC1)S(=O)(=O)NC(C)(C)C
Show InChI InChI=1S/C27H37Cl2N3O5S3/c1-16-19(15-20(28)24(22(16)29)40(36,37)32-27(2,3)4)23-21(14-17-8-6-5-7-9-17)31-26(38-23)25(33)30-18-10-12-39(34,35)13-11-18/h15,17-18,32H,5-14H2,1-4H3,(H,30,33)
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392066
PNG
(US10301272, Example 6/64)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)NCC(C)(C)C(N)=O)c2ccccc12
Show InChI InChI=1S/C30H40N4O4S2/c1-29(2,3)34-40(37,38)24-16-15-22(20-13-9-10-14-21(20)24)25-23(17-19-11-7-6-8-12-19)33-27(39-25)26(35)32-18-30(4,5)28(31)36/h9-10,13-16,19,34H,6-8,11-12,17-18H2,1-5H3,(H2,31,36)(H,32,35)
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before firefly (FF) luciferase activities were measured sequentially in the same cell extract using a Dual-L...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392201
PNG
(US10301272, Example 25/1)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2nc(sc2CC2CCCCC2)C(=O)N[C@H]2C[C@@H](C2)C(O)=O)c2ccccc12
Show InChI InChI=1S/C30H37N3O5S2/c1-30(2,3)33-40(37,38)25-14-13-23(21-11-7-8-12-22(21)25)26-24(15-18-9-5-4-6-10-18)39-28(32-26)27(34)31-20-16-19(17-20)29(35)36/h7-8,11-14,18-20,33H,4-6,9-10,15-17H2,1-3H3,(H,31,34)(H,35,36)/t19-,20-
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392014
PNG
(US10301272, Example 6/12)
Show SMILES CC(NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)NC2CCOCC2)c2ccccc12)C(F)(F)F
Show InChI InChI=1S/C29H34F3N3O4S2/c1-18(29(30,31)32)35-41(37,38)25-12-11-23(21-9-5-6-10-22(21)25)26-24(17-19-7-3-2-4-8-19)34-28(40-26)27(36)33-20-13-15-39-16-14-20/h5-6,9-12,18-20,35H,2-4,7-8,13-17H2,1H3,(H,33,36)
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392076
PNG
(US10301272, Example 7/9)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)N[C@H]2C[C@@H](C2)C(O)=O)c2ccccc12
Show InChI InChI=1S/C30H37N3O5S2/c1-30(2,3)33-40(37,38)25-14-13-23(21-11-7-8-12-22(21)25)26-24(15-18-9-5-4-6-10-18)32-28(39-26)27(34)31-20-16-19(17-20)29(35)36/h7-8,11-14,18-20,33H,4-6,9-10,15-17H2,1-3H3,(H,31,34)(H,35,36)/t19-,20-
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before firefly (FF) luciferase activities were measured sequentially in the same cell extract using a Dual-L...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392005
PNG
(US10301272, Example 6/3)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)NCC2(CCOCC2)C(N)=O)c2ccccc12
Show InChI InChI=1S/C32H42N4O5S2/c1-31(2,3)36-43(39,40)26-14-13-24(22-11-7-8-12-23(22)26)27-25(19-21-9-5-4-6-10-21)35-29(42-27)28(37)34-20-32(30(33)38)15-17-41-18-16-32/h7-8,11-14,21,36H,4-6,9-10,15-20H2,1-3H3,(H2,33,38)(H,34,37)
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392016
PNG
(US10301272, Example 6/14)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)NC2CSC2)c2ccccc12
Show InChI InChI=1S/C28H35N3O3S3/c1-28(2,3)31-37(33,34)24-14-13-22(20-11-7-8-12-21(20)24)25-23(15-18-9-5-4-6-10-18)30-27(36-25)26(32)29-19-16-35-17-19/h7-8,11-14,18-19,31H,4-6,9-10,15-17H2,1-3H3,(H,29,32)
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before firefly (FF) luciferase activities were measured sequentially in the same cell extract using a Dual-L...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392020
PNG
(US10301272, Example 6/18)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)NCC(C)(C)O)c(F)c1C(F)F
Show InChI InChI=1S/C26H36F3N3O4S2/c1-25(2,3)32-38(35,36)18-12-11-16(20(27)19(18)22(28)29)21-17(13-15-9-7-6-8-10-15)31-24(37-21)23(33)30-14-26(4,5)34/h11-12,15,22,32,34H,6-10,13-14H2,1-5H3,(H,30,33)
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392077
PNG
(US10301272, Example 7/10)
Show SMILES CC(NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)N[C@H]2C[C@@H](C2)C(O)=O)c2ccccc12)C(F)(F)F
Show InChI InChI=1S/C29H32F3N3O5S2/c1-16(29(30,31)32)35-42(39,40)24-12-11-22(20-9-5-6-10-21(20)24)25-23(13-17-7-3-2-4-8-17)34-27(41-25)26(36)33-19-14-18(15-19)28(37)38/h5-6,9-12,16-19,35H,2-4,7-8,13-15H2,1H3,(H,33,36)(H,37,38)/t16?,18-,19-
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392100
PNG
(US10301272, Example 8/5)
Show SMILES CC(C)(O)CNC(=O)c1nc(CC2CCCCC2)c(s1)-c1ccc(c2ccccc12)S(=O)(=O)NC1(C)COC1
Show InChI InChI=1S/C29H37N3O5S2/c1-28(2,34)16-30-26(33)27-31-23(15-19-9-5-4-6-10-19)25(38-27)22-13-14-24(21-12-8-7-11-20(21)22)39(35,36)32-29(3)17-37-18-29/h7-8,11-14,19,32,34H,4-6,9-10,15-18H2,1-3H3,(H,30,33)
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392060
PNG
(US10301272, Example 6/58)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)NCC(C)(C)C#N)c2ccccc12
Show InChI InChI=1S/C30H38N4O3S2/c1-29(2,3)34-39(36,37)25-16-15-23(21-13-9-10-14-22(21)25)26-24(17-20-11-7-6-8-12-20)33-28(38-26)27(35)32-19-30(4,5)18-31/h9-10,13-16,20,34H,6-8,11-12,17,19H2,1-5H3,(H,32,35)
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before firefly (FF) luciferase activities were measured sequentially in the same cell extract using a Dual-L...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392245
PNG
(US10301272, Example 205)
Show SMILES CCS(=O)(=O)c1ccc(CNC(=O)c2nc(Cc3ccccc3)c(s2)-c2ccc(c3ccccc23)S(=O)(=O)NC(C)(C)C)cc1
Show InChI InChI=1S/C34H35N3O5S3/c1-5-44(39,40)25-17-15-24(16-18-25)22-35-32(38)33-36-29(21-23-11-7-6-8-12-23)31(43-33)28-19-20-30(27-14-10-9-13-26(27)28)45(41,42)37-34(2,3)4/h6-20,37H,5,21-22H2,1-4H3,(H,35,38)
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392012
PNG
(US10301272, Example 6/10)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)N2CC(C2)C(C)(C)C(O)=O)c2ccccc12
Show InChI InChI=1S/C32H41N3O5S2/c1-31(2,3)34-42(39,40)26-16-15-24(22-13-9-10-14-23(22)26)27-25(17-20-11-7-6-8-12-20)33-28(41-27)29(36)35-18-21(19-35)32(4,5)30(37)38/h9-10,13-16,20-21,34H,6-8,11-12,17-19H2,1-5H3,(H,37,38)
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before firefly (FF) luciferase activities were measured sequentially in the same cell extract using a Dual-L...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392045
PNG
(US10301272, Example 6/43)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)NC2CCS(=O)(=O)CC2)c(Cl)c1Cl
Show InChI InChI=1S/C26H35Cl2N3O5S3/c1-26(2,3)31-39(35,36)20-10-9-18(21(27)22(20)28)23-19(15-16-7-5-4-6-8-16)30-25(37-23)24(32)29-17-11-13-38(33,34)14-12-17/h9-10,16-17,31H,4-8,11-15H2,1-3H3,(H,29,32)
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before firefly (FF) luciferase activities were measured sequentially in the same cell extract using a Dual-L...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392102
PNG
(US10301272, Example 8/7)
Show SMILES C[C@H](NC(=O)c1cc(cc(c1)C1(C)CC1)-c1sc(nc1CC1CCCCC1)C(=O)N[C@H]1C[C@@H](C1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C30H36F3N3O4S/c1-16(30(31,32)33)34-25(37)19-11-18(12-21(13-19)29(2)8-9-29)24-23(10-17-6-4-3-5-7-17)36-27(41-24)26(38)35-22-14-20(15-22)28(39)40/h11-13,16-17,20,22H,3-10,14-15H2,1-2H3,(H,34,37)(H,35,38)(H,39,40)/t16-,20-,22-/m0/s1
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before firefly (FF) luciferase activities were measured sequentially in the same cell extract using a Dual-L...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392245
PNG
(US10301272, Example 205)
Show SMILES CCS(=O)(=O)c1ccc(CNC(=O)c2nc(Cc3ccccc3)c(s2)-c2ccc(c3ccccc23)S(=O)(=O)NC(C)(C)C)cc1
Show InChI InChI=1S/C34H35N3O5S3/c1-5-44(39,40)25-17-15-24(16-18-25)22-35-32(38)33-36-29(21-23-11-7-6-8-12-23)31(43-33)28-19-20-30(27-14-10-9-13-26(27)28)45(41,42)37-34(2,3)4/h6-20,37H,5,21-22H2,1-4H3,(H,35,38)
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before firefly (FF) luciferase activities were measured sequentially in the same cell extract using a Dual-L...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392045
PNG
(US10301272, Example 6/43)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)NC2CCS(=O)(=O)CC2)c(Cl)c1Cl
Show InChI InChI=1S/C26H35Cl2N3O5S3/c1-26(2,3)31-39(35,36)20-10-9-18(21(27)22(20)28)23-19(15-16-7-5-4-6-8-16)30-25(37-23)24(32)29-17-11-13-38(33,34)14-12-17/h9-10,16-17,31H,4-8,11-15H2,1-3H3,(H,29,32)
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392060
PNG
(US10301272, Example 6/58)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)NCC(C)(C)C#N)c2ccccc12
Show InChI InChI=1S/C30H38N4O3S2/c1-29(2,3)34-39(36,37)25-16-15-23(21-13-9-10-14-22(21)25)26-24(17-20-11-7-6-8-12-20)33-28(38-26)27(35)32-19-30(4,5)18-31/h9-10,13-16,20,34H,6-8,11-12,17,19H2,1-5H3,(H,32,35)
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392062
PNG
(US10301272, Example 6/60)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)NCC(C)(C)c2noc(=O)[nH]2)c2ccccc12
Show InChI InChI=1S/C31H39N5O5S2/c1-30(2,3)36-43(39,40)24-16-15-22(20-13-9-10-14-21(20)24)25-23(17-19-11-7-6-8-12-19)33-27(42-25)26(37)32-18-31(4,5)28-34-29(38)41-35-28/h9-10,13-16,19,36H,6-8,11-12,17-18H2,1-5H3,(H,32,37)(H,34,35,38)
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392168
PNG
(US10301272, Example 20 | trans-3-(4-(Cyclohexylmet...)
Show SMILES CC(C)(CCF)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)N[C@H]2C[C@@H](C2)C(O)=O)c2ccccc12
Show InChI InChI=1S/C31H38FN3O5S2/c1-31(2,14-15-32)35-42(39,40)26-13-12-24(22-10-6-7-11-23(22)26)27-25(16-19-8-4-3-5-9-19)34-29(41-27)28(36)33-21-17-20(18-21)30(37)38/h6-7,10-13,19-21,35H,3-5,8-9,14-18H2,1-2H3,(H,33,36)(H,37,38)/t20-,21-
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before firefly (FF) luciferase activities were measured sequentially in the same cell extract using a Dual-L...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392006
PNG
(US10301272, Example 6/4)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)NCC(C)(C)O)c2ccccc12
Show InChI InChI=1S/C29H39N3O4S2/c1-28(2,3)32-38(35,36)24-16-15-22(20-13-9-10-14-21(20)24)25-23(17-19-11-7-6-8-12-19)31-27(37-25)26(33)30-18-29(4,5)34/h9-10,13-16,19,32,34H,6-8,11-12,17-18H2,1-5H3,(H,30,33)
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392012
PNG
(US10301272, Example 6/10)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)N2CC(C2)C(C)(C)C(O)=O)c2ccccc12
Show InChI InChI=1S/C32H41N3O5S2/c1-31(2,3)34-42(39,40)26-16-15-24(22-13-9-10-14-23(22)26)27-25(17-20-11-7-6-8-12-20)33-28(41-27)29(36)35-18-21(19-35)32(4,5)30(37)38/h9-10,13-16,20-21,34H,6-8,11-12,17-19H2,1-5H3,(H,37,38)
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392016
PNG
(US10301272, Example 6/14)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)NC2CSC2)c2ccccc12
Show InChI InChI=1S/C28H35N3O3S3/c1-28(2,3)31-37(33,34)24-14-13-22(20-11-7-8-12-21(20)24)25-23(15-18-9-5-4-6-10-18)30-27(36-25)26(32)29-19-16-35-17-19/h7-8,11-14,18-19,31H,4-6,9-10,15-17H2,1-3H3,(H,29,32)
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392032
PNG
(US10301272, Example 6/30)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)NC2CSC2)c(Cl)c1Cl
Show InChI InChI=1S/C24H31Cl2N3O3S3/c1-24(2,3)29-35(31,32)18-10-9-16(19(25)20(18)26)21-17(11-14-7-5-4-6-8-14)28-23(34-21)22(30)27-15-12-33-13-15/h9-10,14-15,29H,4-8,11-13H2,1-3H3,(H,27,30)
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM392074
PNG
(US10301272, Example 7/7)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)N[C@H]2C[C@@H](C2)C(O)=O)c(Cl)c1Cl
Show InChI InChI=1S/C26H33Cl2N3O5S2/c1-26(2,3)31-38(35,36)19-10-9-17(20(27)21(19)28)22-18(11-14-7-5-4-6-8-14)30-24(37-22)23(32)29-16-12-15(13-16)25(33)34/h9-10,14-16,31H,4-8,11-13H2,1-3H3,(H,29,32)(H,33,34)/t15-,16-
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Phenex Pharmaceuticals AG

US Patent


Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...


US Patent US10301272 (2019)

More data for this
Ligand-Target Pair
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