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Patent code US10301280

Compile Data Set for Download or QSAR

Found 257 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM392372
PNG
(N-(2-phenyl-1H-pyrrolo[2,3-b] pyridin-5-yl)-1H-pyr...)
Show SMILES O=S(=O)(Nc1cnc2[nH]c(cc2c1)-c1ccccc1)c1cn[nH]c1
Show InChI InChI=1S/C16H13N5O2S/c22-24(23,14-9-18-19-10-14)21-13-6-12-7-15(20-16(12)17-8-13)11-4-2-1-3-5-11/h1-10,21H,(H,17,20)(H,18,19)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392373
PNG
(N-[2-(4-fluorophenyl)-1H-pyrrolo [2,3-b]pyridin-5-...)
Show SMILES Cc1cc([nH]n1)C(=O)Nc1cnc2[nH]c(cc2c1)-c1ccc(F)cc1
Show InChI InChI=1S/C18H14FN5O/c1-10-6-16(24-23-10)18(25)21-14-7-12-8-15(22-17(12)20-9-14)11-2-4-13(19)5-3-11/h2-9H,1H3,(H,20,22)(H,21,25)(H,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM392382
PNG
(2-ethyl-N-[2-(4-fluorophenyl)-1H- pyrrolo[2,3-b]py...)
Show SMILES CCn1nccc1S(=O)(=O)Nc1cnc2[nH]c(cc2c1)-c1ccc(F)cc1
Show InChI InChI=1S/C18H16FN5O2S/c1-2-24-17(7-8-21-24)27(25,26)23-15-9-13-10-16(22-18(13)20-11-15)12-3-5-14(19)6-4-12/h3-11,23H,2H2,1H3,(H,20,22)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392398
PNG
(N-[2-(4-fluorophenyl)-1H-pyrrolo [2,3-b]pyridin-5-...)
Show SMILES Fc1ccc(cc1)-c1cc2cc(NC(=O)c3n[nH]c4CCCCc34)cnc2[nH]1
Show InChI InChI=1S/C21H18FN5O/c22-14-7-5-12(6-8-14)18-10-13-9-15(11-23-20(13)25-18)24-21(28)19-16-3-1-2-4-17(16)26-27-19/h5-11H,1-4H2,(H,23,25)(H,24,28)(H,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392437
PNG
(3-methyl-N-(2-pyrazol-1-yl-1H- pyrrolo[2,3-b]pyrid...)
Show SMILES Cc1cc([nH]n1)C(=O)Nc1cnc2[nH]c(cc2c1)-n1cccn1
Show InChI InChI=1S/C15H13N7O/c1-9-5-12(21-20-9)15(23)18-11-6-10-7-13(19-14(10)16-8-11)22-4-2-3-17-22/h2-8H,1H3,(H,16,19)(H,18,23)(H,20,21)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392477
PNG
(N-[2-(5-methoxy-3-pyridyl)-1H- pyrrolo[2,3-b]pyrid...)
Show SMILES COc1cncc(c1)-c1cc2cc(NC(=O)c3[nH]nc(C)c3C)cnc2[nH]1
Show InChI InChI=1S/C19H18N6O2/c1-10-11(2)24-25-17(10)19(26)22-14-4-12-6-16(23-18(12)21-8-14)13-5-15(27-3)9-20-7-13/h4-9H,1-3H3,(H,21,23)(H,22,26)(H,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392488
PNG
(3-[5-[(3,4-dimethyl-1H-pyrazole-5- carbonyl)amino]...)
Show SMILES Cc1n[nH]c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2cnccc2C(N)=O)c1C
Show InChI InChI=1S/C19H17N7O2/c1-9-10(2)25-26-16(9)19(28)23-12-5-11-6-15(24-18(11)22-7-12)14-8-21-4-3-13(14)17(20)27/h3-8H,1-2H3,(H2,20,27)(H,22,24)(H,23,28)(H,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM392328
PNG
(N-(3-carbamoylphenyl)-2-phenyl- 1H-pyrrolo[2,3-b]p...)
Show SMILES NC(=O)c1cccc(NC(=O)c2cnc3[nH]c(cc3c2)-c2ccccc2)c1
Show InChI InChI=1S/C21H16N4O2/c22-19(26)14-7-4-8-17(10-14)24-21(27)16-9-15-11-18(25-20(15)23-12-16)13-5-2-1-3-6-13/h1-12H,(H2,22,26)(H,23,25)(H,24,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392377
PNG
(N-[2-(4-fluorophenyl)-1H-pyrrolo [2,3-b]pyridin-5-...)
Show SMILES Cc1n[nH]c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2ccc(F)cc2)c1C
Show InChI InChI=1S/C19H16FN5O/c1-10-11(2)24-25-17(10)19(26)22-15-7-13-8-16(23-18(13)21-9-15)12-3-5-14(20)6-4-12/h3-9H,1-2H3,(H,21,23)(H,22,26)(H,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM392379
PNG
(3-acetamido-N-[2-(4-fluorophenyl)- 1H-pyrrolo[2,3-...)
Show SMILES CC(=O)Nc1cccc(c1)C(=O)Nc1cnc2[nH]c(cc2c1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H17FN4O2/c1-13(28)25-18-4-2-3-15(9-18)22(29)26-19-10-16-11-20(27-21(16)24-12-19)14-5-7-17(23)8-6-14/h2-12H,1H3,(H,24,27)(H,25,28)(H,26,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392400
PNG
(N-(2-chloro-1H-pyrrolo[2,3-b] pyridin-5-yl)-3,4-di...)
Show SMILES Cc1n[nH]c(C(=O)Nc2cnc3[nH]c(Cl)cc3c2)c1C
Show InChI InChI=1S/C13H12ClN5O/c1-6-7(2)18-19-11(6)13(20)16-9-3-8-4-10(14)17-12(8)15-5-9/h3-5H,1-2H3,(H,15,17)(H,16,20)(H,18,19)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392409
PNG
(3-methyl-N-(2-morpholino-1H- pyrrolo[2,3-b]pyridin...)
Show SMILES Cc1cc([nH]n1)C(=O)Nc1cnc2[nH]c(cc2c1)N1CCOCC1
Show InChI InChI=1S/C16H18N6O2/c1-10-6-13(21-20-10)16(23)18-12-7-11-8-14(19-15(11)17-9-12)22-2-4-24-5-3-22/h6-9H,2-5H2,1H3,(H,17,19)(H,18,23)(H,20,21)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM392371
PNG
(4,5-dimethyl-N-(2-phenyl-1H- pyrrolo[2,3-b]pyridin...)
Show SMILES Cc1onc(C(=O)Nc2cnc3[nH]c(cc3c2)-c2ccccc2)c1C
Show InChI InChI=1S/C19H16N4O2/c1-11-12(2)25-23-17(11)19(24)21-15-8-14-9-16(22-18(14)20-10-15)13-6-4-3-5-7-13/h3-10H,1-2H3,(H,20,22)(H,21,24)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392396
PNG
(N-(6-anilino-3-pyridyl)-3,4-dimethyl- 1H-pyrazole-...)
Show SMILES Cc1n[nH]c(C(=O)Nc2ccc(Nc3ccccc3)nc2)c1C
Show InChI InChI=1S/C17H17N5O/c1-11-12(2)21-22-16(11)17(23)20-14-8-9-15(18-10-14)19-13-6-4-3-5-7-13/h3-10H,1-2H3,(H,18,19)(H,20,23)(H,21,22)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392507
PNG
(3-[(2-phenyl-1H-pyrrolo[2,3- b]pyridin-5-yl)carbam...)
Show SMILES OC(=O)c1cccc(c1)C(=O)Nc1cnc2[nH]c(cc2c1)-c1ccccc1
Show InChI InChI=1S/C21H15N3O3/c25-20(14-7-4-8-15(9-14)21(26)27)23-17-10-16-11-18(24-19(16)22-12-17)13-5-2-1-3-6-13/h1-12H,(H,22,24)(H,23,25)(H,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392365
PNG
(5-fluoro-N-(2-phenyl-1H-pyrrolo [2,3-b]pyridin-5-y...)
Show SMILES Fc1ccc2[nH]nc(C(=O)Nc3cnc4[nH]c(cc4c3)-c3ccccc3)c2c1
Show InChI InChI=1S/C21H14FN5O/c22-14-6-7-17-16(10-14)19(27-26-17)21(28)24-15-8-13-9-18(25-20(13)23-11-15)12-4-2-1-3-5-12/h1-11H,(H,23,25)(H,24,28)(H,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM392366
PNG
(N-(2-phenyl-1H-pyrrolo[2,3-b] pyridin-5-yl)pyrimid...)
Show SMILES O=C(Nc1cnc2[nH]c(cc2c1)-c1ccccc1)c1ccncn1
Show InChI InChI=1S/C18H13N5O/c24-18(15-6-7-19-11-21-15)22-14-8-13-9-16(23-17(13)20-10-14)12-4-2-1-3-5-12/h1-11H,(H,20,23)(H,22,24)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392401
PNG
(N-[2-[3- (ethylsulfamoyl)anilino]pyrimidin-5- yl]-...)
Show SMILES CCNS(=O)(=O)c1cccc(Nc2ncc(NC(=O)c3[nH]nc(C)c3C)cn2)c1
Show InChI InChI=1S/C18H21N7O3S/c1-4-21-29(27,28)15-7-5-6-13(8-15)23-18-19-9-14(10-20-18)22-17(26)16-11(2)12(3)24-25-16/h5-10,21H,4H2,1-3H3,(H,22,26)(H,24,25)(H,19,20,23)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392470
PNG
(3,4-dimethyl-N-[2-[2- (trifluoromethyl)-3-pyridyl]...)
Show SMILES Cc1n[nH]c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2cccnc2C(F)(F)F)c1C
Show InChI InChI=1S/C19H15F3N6O/c1-9-10(2)27-28-15(9)18(29)25-12-6-11-7-14(26-17(11)24-8-12)13-4-3-5-23-16(13)19(20,21)22/h3-8H,1-2H3,(H,24,26)(H,25,29)(H,27,28)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392489
PNG
(N-[2-(2,3-dihydrobenzofuran-7-yl)- 1H-pyrrolo[2,3-...)
Show SMILES Cc1n[nH]c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2cccc3CCOc23)c1C
Show InChI InChI=1S/C21H19N5O2/c1-11-12(2)25-26-18(11)21(27)23-15-8-14-9-17(24-20(14)22-10-15)16-5-3-4-13-6-7-28-19(13)16/h3-5,8-10H,6-7H2,1-2H3,(H,22,24)(H,23,27)(H,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392494
PNG
(N-[2-(3-chloro-4-pyridyl)-1H- pyrrolo[2,3-b]pyridi...)
Show SMILES Cc1n[nH]c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2ccncc2Cl)c1C
Show InChI InChI=1S/C18H15ClN6O/c1-9-10(2)24-25-16(9)18(26)22-12-5-11-6-15(23-17(11)21-7-12)13-3-4-20-8-14(13)19/h3-8H,1-2H3,(H,21,23)(H,22,26)(H,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392497
PNG
(N-[2-(2,2-difluoro-1,3- benzodioxol-4-yl)-1H- pyrr...)
Show SMILES Cc1n[nH]c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2cccc3OC(F)(F)Oc23)c1C
Show InChI InChI=1S/C20H15F2N5O3/c1-9-10(2)26-27-16(9)19(28)24-12-6-11-7-14(25-18(11)23-8-12)13-4-3-5-15-17(13)30-20(21,22)29-15/h3-8H,1-2H3,(H,23,25)(H,24,28)(H,26,27)
PDB

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<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392514
PNG
(N-(2-methyl-1H-pyrrolo[2,3- b]pyridin-5-yl)-2H-ind...)
Show SMILES Cc1cc2cc(NC(=O)c3cccc4n[nH]cc34)cnc2[nH]1
Show InChI InChI=1S/C16H13N5O/c1-9-5-10-6-11(7-17-15(10)19-9)20-16(22)12-3-2-4-14-13(12)8-18-21-14/h2-8H,1H3,(H,17,19)(H,18,21)(H,20,22)
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<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM392368
PNG
(3,5-dimethyl-N-(2-phenyl-1H- pyrrolo[2,3-b]pyridin...)
Show SMILES Cc1noc(C)c1C(=O)Nc1cnc2[nH]c(cc2c1)-c1ccccc1
Show InChI InChI=1S/C19H16N4O2/c1-11-17(12(2)25-23-11)19(24)21-15-8-14-9-16(22-18(14)20-10-15)13-6-4-3-5-7-13/h3-10H,1-2H3,(H,20,22)(H,21,24)
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<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM392378
PNG
(3-cyano-N-[2-(4-fluorophenyl)-1H- pyrrolo[2,3-b]py...)
Show SMILES Fc1ccc(cc1)-c1cc2cc(NC(=O)c3cccc(c3)C#N)cnc2[nH]1
Show InChI InChI=1S/C21H13FN4O/c22-17-6-4-14(5-7-17)19-10-16-9-18(12-24-20(16)26-19)25-21(27)15-3-1-2-13(8-15)11-23/h1-10,12H,(H,24,26)(H,25,27)
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<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392486
PNG
(N-[2-(5-cyano-3-pyridyl)-1H- pyrrolo[2,3-b]pyridin...)
Show SMILES Cc1n[nH]c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2cncc(c2)C#N)c1C
Show InChI InChI=1S/C19H15N7O/c1-10-11(2)25-26-17(10)19(27)23-15-4-13-5-16(24-18(13)22-9-15)14-3-12(6-20)7-21-8-14/h3-5,7-9H,1-2H3,(H,22,24)(H,23,27)(H,25,26)
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<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392395
PNG
(N-(2-anilinopyrimidin-5-yl)-3,4- dimethyl-1H-pyraz...)
Show SMILES Cc1n[nH]c(C(=O)Nc2cnc(Nc3ccccc3)nc2)c1C
Show InChI InChI=1S/C16H16N6O/c1-10-11(2)21-22-14(10)15(23)19-13-8-17-16(18-9-13)20-12-6-4-3-5-7-12/h3-9H,1-2H3,(H,19,23)(H,21,22)(H,17,18,20)
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<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM392422
PNG
(N-(4,5-dimethyl-1H-pyrazol-3-yl)-2- phenyl-1H-pyrr...)
Show SMILES Cc1[nH]nc(NC(=O)c2cnc3[nH]c(cc3c2)-c2ccccc2)c1C
Show InChI InChI=1S/C19H17N5O/c1-11-12(2)23-24-17(11)22-19(25)15-8-14-9-16(21-18(14)20-10-15)13-6-4-3-5-7-13/h3-10H,1-2H3,(H,20,21)(H2,22,23,24,25)
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<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392438
PNG
(N-[2-[3-[4- (cyclopropanecarbonyl)piperazin-1- yl]...)
Show SMILES Cc1n[nH]c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2cccc(c2)N2CCN(CC2)C(=O)C2CC2)c1C
Show InChI InChI=1S/C27H29N7O2/c1-16-17(2)31-32-24(16)26(35)29-21-12-20-14-23(30-25(20)28-15-21)19-4-3-5-22(13-19)33-8-10-34(11-9-33)27(36)18-6-7-18/h3-5,12-15,18H,6-11H2,1-2H3,(H,28,30)(H,29,35)(H,31,32)
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<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392493
PNG
(N-[2-(4-chloro-2-methyl-phenyl)- 1H-pyrrolo[2,3-b]...)
Show SMILES Cc1n[nH]c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2ccc(Cl)cc2C)c1C
Show InChI InChI=1S/C20H18ClN5O/c1-10-6-14(21)4-5-16(10)17-8-13-7-15(9-22-19(13)24-17)23-20(27)18-11(2)12(3)25-26-18/h4-9H,1-3H3,(H,22,24)(H,23,27)(H,25,26)
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<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392506
PNG
(US10301280, Compound P-2290 | methyl 3-[(2-phenyl-...)
Show SMILES COC(=O)c1cccc(c1)C(=O)Nc1cnc2[nH]c(cc2c1)-c1ccccc1
Show InChI InChI=1S/C22H17N3O3/c1-28-22(27)16-9-5-8-15(10-16)21(26)24-18-11-17-12-19(25-20(17)23-13-18)14-6-3-2-4-7-14/h2-13H,1H3,(H,23,25)(H,24,26)
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<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392384
PNG
(3,4-dimethyl-N-(1H-pyrrolo[2,3- b]pyridin-5-yl)-1H...)
Show SMILES Cc1n[nH]c(C(=O)Nc2cnc3[nH]ccc3c2)c1C
Show InChI InChI=1S/C13H13N5O/c1-7-8(2)17-18-11(7)13(19)16-10-5-9-3-4-14-12(9)15-6-10/h3-6H,1-2H3,(H,14,15)(H,16,19)(H,17,18)
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<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392397
PNG
(N-[2-(4-fluorophenyl)-1H-pyrrolo [2,3-b]pyridin-5-...)
Show SMILES Fc1ccc(cc1)-c1cc2cc(NC(=O)c3n[nH]c4ccccc34)cnc2[nH]1
Show InChI InChI=1S/C21H14FN5O/c22-14-7-5-12(6-8-14)18-10-13-9-15(11-23-20(13)25-18)24-21(28)19-16-3-1-2-4-17(16)26-27-19/h1-11H,(H,23,25)(H,24,28)(H,26,27)
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<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392475
PNG
(N-[2-(2,4-dimethylphenyl)-1H- pyrrolo[2,3-b]pyridi...)
Show SMILES Cc1n[nH]c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2ccc(C)cc2C)c1C
Show InChI InChI=1S/C21H21N5O/c1-11-5-6-17(12(2)7-11)18-9-15-8-16(10-22-20(15)24-18)23-21(27)19-13(3)14(4)25-26-19/h5-10H,1-4H3,(H,22,24)(H,23,27)(H,25,26)
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<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM392507
PNG
(3-[(2-phenyl-1H-pyrrolo[2,3- b]pyridin-5-yl)carbam...)
Show SMILES OC(=O)c1cccc(c1)C(=O)Nc1cnc2[nH]c(cc2c1)-c1ccccc1
Show InChI InChI=1S/C21H15N3O3/c25-20(14-7-4-8-15(9-14)21(26)27)23-17-10-16-11-18(24-19(16)22-12-17)13-5-2-1-3-6-13/h1-12H,(H,22,24)(H,23,25)(H,26,27)
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<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM392364
PNG
(3-cyclopropyl-N-(2-phenyl-1H- pyrrolo[2,3-b]pyridi...)
Show SMILES O=C(Nc1cnc2[nH]c(cc2c1)-c1ccccc1)c1cc(n[nH]1)C1CC1
Show InChI InChI=1S/C20H17N5O/c26-20(18-10-17(24-25-18)13-6-7-13)22-15-8-14-9-16(23-19(14)21-11-15)12-4-2-1-3-5-12/h1-5,8-11,13H,6-7H2,(H,21,23)(H,22,26)(H,24,25)
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<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM392375
PNG
(3-(cyanomethyl)-N-[2-(4- fluorophenyl)- 1H-pyrrolo...)
Show SMILES Fc1ccc(cc1)-c1cc2cc(NC(=O)c3cccc(CC#N)c3)cnc2[nH]1
Show InChI InChI=1S/C22H15FN4O/c23-18-6-4-15(5-7-18)20-12-17-11-19(13-25-21(17)27-20)26-22(28)16-3-1-2-14(10-16)8-9-24/h1-7,10-13H,8H2,(H,25,27)(H,26,28)
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<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392385
PNG
(N-[1-(benzenesulfonyl)-2-[1- (morpholine-4-carbony...)
Show SMILES Cc1n[nH]c(C(=O)Nc2cnc3n(c(cc3c2)C2=CCN(CC2)C(=O)N2CCOCC2)S(=O)(=O)c2ccccc2)c1C
Show InChI InChI=1S/C29H31N7O5S/c1-19-20(2)32-33-26(19)28(37)31-23-16-22-17-25(21-8-10-34(11-9-21)29(38)35-12-14-41-15-13-35)36(27(22)30-18-23)42(39,40)24-6-4-3-5-7-24/h3-8,16-18H,9-15H2,1-2H3,(H,31,37)(H,32,33)
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<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392391
PNG
(3,4-dimethyl-N-(3-methyl-1H- pyrazolo[3,4-b]pyridi...)
Show SMILES Cc1n[nH]c(C(=O)Nc2cnc3[nH]nc(C)c3c2)c1C
Show InChI InChI=1S/C13H14N6O/c1-6-7(2)16-18-11(6)13(20)15-9-4-10-8(3)17-19-12(10)14-5-9/h4-5H,1-3H3,(H,15,20)(H,16,18)(H,14,17,19)
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<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392472
PNG
(N-[2-(6-ethyl-3-pyridyl)-1H- pyrrolo[2,3-b]pyridin...)
Show SMILES CCc1ccc(cn1)-c1cc2cc(NC(=O)c3[nH]nc(C)c3C)cnc2[nH]1
Show InChI InChI=1S/C20H20N6O/c1-4-15-6-5-13(9-21-15)17-8-14-7-16(10-22-19(14)24-17)23-20(27)18-11(2)12(3)25-26-18/h5-10H,4H2,1-3H3,(H,22,24)(H,23,27)(H,25,26)
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<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392495
PNG
(N-[2-(4-fluoro-2,3-dimethyl- phenyl)-1H-pyrrolo[2,...)
Show SMILES Cc1n[nH]c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2ccc(F)c(C)c2C)c1C
Show InChI InChI=1S/C21H20FN5O/c1-10-11(2)17(22)6-5-16(10)18-8-14-7-15(9-23-20(14)25-18)24-21(28)19-12(3)13(4)26-27-19/h5-9H,1-4H3,(H,23,25)(H,24,28)(H,26,27)
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<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392496
PNG
(N-[2-(2,6-difluoro-3-pyridyl)-1H- pyrrolo[2,3-b]py...)
Show SMILES Cc1n[nH]c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2ccc(F)nc2F)c1C
Show InChI InChI=1S/C18H14F2N6O/c1-8-9(2)25-26-15(8)18(27)22-11-5-10-6-13(23-17(10)21-7-11)12-3-4-14(19)24-16(12)20/h3-7H,1-2H3,(H,21,23)(H,22,27)(H,25,26)
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<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM392506
PNG
(US10301280, Compound P-2290 | methyl 3-[(2-phenyl-...)
Show SMILES COC(=O)c1cccc(c1)C(=O)Nc1cnc2[nH]c(cc2c1)-c1ccccc1
Show InChI InChI=1S/C22H17N3O3/c1-28-22(27)16-9-5-8-15(10-16)21(26)24-18-11-17-12-19(25-20(17)23-13-18)14-6-3-2-4-7-14/h2-13H,1H3,(H,23,25)(H,24,26)
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<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM392365
PNG
(5-fluoro-N-(2-phenyl-1H-pyrrolo [2,3-b]pyridin-5-y...)
Show SMILES Fc1ccc2[nH]nc(C(=O)Nc3cnc4[nH]c(cc4c3)-c3ccccc3)c2c1
Show InChI InChI=1S/C21H14FN5O/c22-14-6-7-17-16(10-14)19(27-26-17)21(28)24-15-8-13-9-18(25-20(13)23-11-15)12-4-2-1-3-5-12/h1-11H,(H,23,25)(H,24,28)(H,26,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392372
PNG
(N-(2-phenyl-1H-pyrrolo[2,3-b] pyridin-5-yl)-1H-pyr...)
Show SMILES O=S(=O)(Nc1cnc2[nH]c(cc2c1)-c1ccccc1)c1cn[nH]c1
Show InChI InChI=1S/C16H13N5O2S/c22-24(23,14-9-18-19-10-14)21-13-6-12-7-15(20-16(12)17-8-13)11-4-2-1-3-5-11/h1-10,21H,(H,17,20)(H,18,19)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<1.00E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM392401
PNG
(N-[2-[3- (ethylsulfamoyl)anilino]pyrimidin-5- yl]-...)
Show SMILES CCNS(=O)(=O)c1cccc(Nc2ncc(NC(=O)c3[nH]nc(C)c3C)cn2)c1
Show InChI InChI=1S/C18H21N7O3S/c1-4-21-29(27,28)15-7-5-6-13(8-15)23-18-19-9-14(10-20-18)22-17(26)16-11(2)12(3)24-25-16/h5-10,21H,4H2,1-3H3,(H,22,26)(H,24,25)(H,19,20,23)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
5.50E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392480
PNG
(3,4-dimethyl-N-[2-[2-(4- methylsulfonylpiperazin-1...)
Show SMILES Cc1n[nH]c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2ccnc(c2)N2CCN(CC2)S(C)(=O)=O)c1C
Show InChI InChI=1S/C23H26N8O3S/c1-14-15(2)28-29-21(14)23(32)26-18-10-17-11-19(27-22(17)25-13-18)16-4-5-24-20(12-16)30-6-8-31(9-7-30)35(3,33)34/h4-5,10-13H,6-9H2,1-3H3,(H,25,27)(H,26,32)(H,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
5.50E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM392428
PNG
(N-[2-(2-chloro-5-methoxy-phenyl)- 1H-pyrrolo[2,3-b...)
Show SMILES COc1ccc(Cl)c(c1)-c1cc2cc(NC(=O)c3[nH]nc(C)c3C)cnc2[nH]1
Show InChI InChI=1S/C20H18ClN5O2/c1-10-11(2)25-26-18(10)20(27)23-13-6-12-7-17(24-19(12)22-9-13)15-8-14(28-3)4-5-16(15)21/h4-9H,1-3H3,(H,22,24)(H,23,27)(H,25,26)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
5.50E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM392431
PNG
(N-[2-(4-aminocyclohexen-1-yl)-1H- pyrrolo[2,3-b]py...)
Show SMILES Cc1n[nH]c(C(=O)Nc2cnc3[nH]c(cc3c2)C2=CCC(N)CC2)c1C
Show InChI InChI=1/C19H22N6O/c1-10-11(2)24-25-17(10)19(26)22-15-7-13-8-16(23-18(13)21-9-15)12-3-5-14(20)6-4-12/h3,7-9,14H,4-6,20H2,1-2H3,(H,21,23)(H,22,26)(H,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
5.50E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM392437
PNG
(3-methyl-N-(2-pyrazol-1-yl-1H- pyrrolo[2,3-b]pyrid...)
Show SMILES Cc1cc([nH]n1)C(=O)Nc1cnc2[nH]c(cc2c1)-n1cccn1
Show InChI InChI=1S/C15H13N7O/c1-9-5-12(21-20-9)15(23)18-11-6-10-7-13(19-14(10)16-8-11)22-4-2-3-17-22/h2-8H,1H3,(H,16,19)(H,18,23)(H,20,21)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
5.50E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...


US Patent US10301280 (2019)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%