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Patent code US10301288

Compile Data Set for Download or QSAR
Found 61 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM392703
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-(3-((dimethylphosph...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4cccc(CP(C)(C)=O)c4)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C47H53N8O7P/c1-8-32-26-34(44(56)48-20-21-60-24-25-61-23-22-59-5)29-35(27-32)50-45-49-19-18-43(53-45)62-40-17-16-39(37-14-9-10-15-38(37)40)51-46(57)52-42-30-41(47(2,3)4)54-55(42)36-13-11-12-33(28-36)31-63(6,7)58/h1,9-19,26-30H,20-25,31H2,2-7H3,(H,48,56)(H,49,50,53)(H2,51,52,57)
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n/an/a 4n/an/an/an/an/an/a



Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM392690
PNG
(3-Ethynyl-5-((4-((4-(3-(3-isopropyl-1-(p-tolyl)-1H...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C44H46N8O6/c1-6-31-25-32(42(53)45-19-20-56-23-24-57-22-21-55-5)27-33(26-31)47-43-46-18-17-41(50-43)58-39-16-15-37(35-9-7-8-10-36(35)39)48-44(54)49-40-28-38(29(2)3)51-52(40)34-13-11-30(4)12-14-34/h1,7-18,25-29H,19-24H2,2-5H3,(H,45,53)(H,46,47,50)(H2,48,49,54)
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Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM392694
PNG
(US10301288, Example 5)
Show SMILES COCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(OC)cc4)C(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C42H42N8O6/c1-6-28-23-29(40(51)43-19-20-55-22-21-53-4)25-30(24-28)45-41-44-18-17-39(48-41)56-37-16-15-35(33-9-7-8-10-34(33)37)46-42(52)47-38-26-36(27(2)3)49-50(38)31-11-13-32(54-5)14-12-31/h1,7-18,23-27H,19-22H2,2-5H3,(H,43,51)(H,44,45,48)(H2,46,47,52)
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Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM392692
PNG
(US10301288, Example 3)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(OC)cc4)C(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C44H46N8O7/c1-6-30-25-31(42(53)45-19-20-57-23-24-58-22-21-55-4)27-32(26-30)47-43-46-18-17-41(50-43)59-39-16-15-37(35-9-7-8-10-36(35)39)48-44(54)49-40-28-38(29(2)3)51-52(40)33-11-13-34(56-5)14-12-33/h1,7-18,25-29H,19-24H2,2-5H3,(H,45,53)(H,46,47,50)(H2,48,49,54)
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Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM392705
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-(4-(dimethylamino)p...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(cc4)N(C)C)C(C)(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C45H53N9O7/c1-45(2,3)39-29-40(54(52-39)33-14-12-32(13-15-33)53(4)5)50-44(56)49-37-16-17-38(36-11-9-8-10-35(36)37)61-41-18-19-47-43(51-41)48-31-26-30(27-34(28-31)58-7)42(55)46-20-21-59-24-25-60-23-22-57-6/h8-19,26-29H,20-25H2,1-7H3,(H,46,55)(H,47,48,51)(H2,49,50,56)
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Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM392698
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-(4-(dimethylamino)p...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(cc4)N(C)C)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C46H51N9O6/c1-8-31-27-32(43(56)47-21-22-59-25-26-60-24-23-58-7)29-33(28-31)49-44-48-20-19-42(52-44)61-39-18-17-38(36-11-9-10-12-37(36)39)50-45(57)51-41-30-40(46(2,3)4)53-55(41)35-15-13-34(14-16-35)54(5)6/h1,9-20,27-30H,21-26H2,2-7H3,(H,47,56)(H,48,49,52)(H2,50,51,57)
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM392695
PNG
(US10301288, Example 12 | US10301288, Example 6)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C45H48N8O6/c1-7-31-26-32(42(54)46-20-21-57-24-25-58-23-22-56-6)28-33(27-31)48-43-47-19-18-41(51-43)59-38-17-16-37(35-10-8-9-11-36(35)38)49-44(55)50-40-29-39(45(3,4)5)52-53(40)34-14-12-30(2)13-15-34/h1,8-19,26-29H,20-25H2,2-6H3,(H,46,54)(H,47,48,51)(H2,49,50,55)
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM392696
PNG
(US10301288, Example 7)
Show SMILES COCCOCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C47H52N8O7/c1-7-33-28-34(44(56)48-20-21-59-24-25-61-27-26-60-23-22-58-6)30-35(29-33)50-45-49-19-18-43(53-45)62-40-17-16-39(37-10-8-9-11-38(37)40)51-46(57)52-42-31-41(47(3,4)5)54-55(42)36-14-12-32(2)13-15-36/h1,8-19,28-31H,20-27H2,2-6H3,(H,48,56)(H,49,50,53)(H2,51,52,57)
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM392704
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-(3-((dimethylphosph...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(nn4-c4cccc(CP(C)(C)=O)c4)C(C)(C)C)c4ccccc34)ccn2)cc(OC)c1
Show InChI InChI=1S/C47H56N7O8P/c1-47(2,3)42-30-44(54(53-42)35-12-10-11-32(25-35)31-63(6,7)57)52-46(56)51-40-15-16-41(39-14-9-8-13-38(39)40)62-36-17-18-48-43(29-36)50-34-26-33(27-37(28-34)59-5)45(55)49-19-20-60-23-24-61-22-21-58-4/h8-18,25-30H,19-24,31H2,1-7H3,(H,48,50)(H,49,55)(H2,51,52,56)
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM392693
PNG
(US10301288, Example 4)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)ccn2)cc(OC)c1
Show InChI InChI=1S/C44H49N7O7/c1-29(2)39-28-42(51(50-39)33-12-10-30(3)11-13-33)49-44(53)48-38-14-15-40(37-9-7-6-8-36(37)38)58-34-16-17-45-41(27-34)47-32-24-31(25-35(26-32)55-5)43(52)46-18-19-56-22-23-57-21-20-54-4/h6-17,24-29H,18-23H2,1-5H3,(H,45,47)(H,46,52)(H2,48,49,53)
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Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM392697
PNG
(US10301288, Example 8)
Show SMILES COCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C43H44N8O5/c1-7-29-24-30(40(52)44-20-21-55-23-22-54-6)26-31(25-29)46-41-45-19-18-39(49-41)56-36-17-16-35(33-10-8-9-11-34(33)36)47-42(53)48-38-27-37(43(3,4)5)50-51(38)32-14-12-28(2)13-15-32/h1,8-19,24-27H,20-23H2,2-6H3,(H,44,52)(H,45,46,49)(H2,47,48,53)
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Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM392703
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-(3-((dimethylphosph...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4cccc(CP(C)(C)=O)c4)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C47H53N8O7P/c1-8-32-26-34(44(56)48-20-21-60-24-25-61-23-22-59-5)29-35(27-32)50-45-49-19-18-43(53-45)62-40-17-16-39(37-14-9-10-15-38(37)40)51-46(57)52-42-30-41(47(2,3)4)54-55(42)36-13-11-12-33(28-36)31-63(6,7)58/h1,9-19,26-30H,20-25,31H2,2-7H3,(H,48,56)(H,49,50,53)(H2,51,52,57)
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Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM392702
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-(2,4-dimethoxypheny...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(OC)cc4OC)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C46H50N8O8/c1-8-30-25-31(43(55)47-19-20-60-23-24-61-22-21-57-5)27-32(26-30)49-44-48-18-17-42(52-44)62-38-16-14-36(34-11-9-10-12-35(34)38)50-45(56)51-41-29-40(46(2,3)4)53-54(41)37-15-13-33(58-6)28-39(37)59-7/h1,9-18,25-29H,19-24H2,2-7H3,(H,47,55)(H,48,49,52)(H2,50,51,56)
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM392690
PNG
(3-Ethynyl-5-((4-((4-(3-(3-isopropyl-1-(p-tolyl)-1H...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C44H46N8O6/c1-6-31-25-32(42(53)45-19-20-56-23-24-57-22-21-55-5)27-33(26-31)47-43-46-18-17-41(50-43)58-39-16-15-37(35-9-7-8-10-36(35)39)48-44(54)49-40-28-38(29(2)3)51-52(40)34-13-11-30(4)12-14-34/h1,7-18,25-29H,19-24H2,2-5H3,(H,45,53)(H,46,47,50)(H2,48,49,54)
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Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determining the leve...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM392699
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-(4-(dimethylamino)p...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(cc4)N(C)C)C(C)(C)C)c4ccccc34)ccn2)cc(OC)c1
Show InChI InChI=1S/C46H54N8O7/c1-46(2,3)41-30-43(54(52-41)34-14-12-33(13-15-34)53(4)5)51-45(56)50-39-16-17-40(38-11-9-8-10-37(38)39)61-35-18-19-47-42(29-35)49-32-26-31(27-36(28-32)58-7)44(55)48-20-21-59-24-25-60-23-22-57-6/h8-19,26-30H,20-25H2,1-7H3,(H,47,49)(H,48,55)(H2,50,51,56)
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM392705
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-(4-(dimethylamino)p...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(cc4)N(C)C)C(C)(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C45H53N9O7/c1-45(2,3)39-29-40(54(52-39)33-14-12-32(13-15-33)53(4)5)50-44(56)49-37-16-17-38(36-11-9-8-10-35(36)37)61-41-18-19-47-43(51-41)48-31-26-30(27-34(28-31)58-7)42(55)46-20-21-59-24-25-60-23-22-57-6/h8-19,26-29H,20-25H2,1-7H3,(H,46,55)(H,47,48,51)(H2,49,50,56)
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Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM392690
PNG
(3-Ethynyl-5-((4-((4-(3-(3-isopropyl-1-(p-tolyl)-1H...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C44H46N8O6/c1-6-31-25-32(42(53)45-19-20-56-23-24-57-22-21-55-5)27-33(26-31)47-43-46-18-17-41(50-43)58-39-16-15-37(35-9-7-8-10-36(35)39)48-44(54)49-40-28-38(29(2)3)51-52(40)34-13-11-30(4)12-14-34/h1,7-18,25-29H,19-24H2,2-5H3,(H,45,53)(H,46,47,50)(H2,48,49,54)
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Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM392692
PNG
(US10301288, Example 3)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(OC)cc4)C(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C44H46N8O7/c1-6-30-25-31(42(53)45-19-20-57-23-24-58-22-21-55-4)27-32(26-30)47-43-46-18-17-41(50-43)59-39-16-15-37(35-9-7-8-10-36(35)39)48-44(54)49-40-28-38(29(2)3)51-52(40)33-11-13-34(56-5)14-12-33/h1,7-18,25-29H,19-24H2,2-5H3,(H,45,53)(H,46,47,50)(H2,48,49,54)
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Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM392694
PNG
(US10301288, Example 5)
Show SMILES COCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(OC)cc4)C(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C42H42N8O6/c1-6-28-23-29(40(51)43-19-20-55-22-21-53-4)25-30(24-28)45-41-44-18-17-39(48-41)56-37-16-15-35(33-9-7-8-10-34(33)37)46-42(52)47-38-26-36(27(2)3)49-50(38)31-11-13-32(54-5)14-12-31/h1,7-18,23-27H,19-22H2,2-5H3,(H,43,51)(H,44,45,48)(H2,46,47,52)
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n/an/a 33n/an/an/an/an/an/a



Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determining the leve...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM392704
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-(3-((dimethylphosph...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(nn4-c4cccc(CP(C)(C)=O)c4)C(C)(C)C)c4ccccc34)ccn2)cc(OC)c1
Show InChI InChI=1S/C47H56N7O8P/c1-47(2,3)42-30-44(54(53-42)35-12-10-11-32(25-35)31-63(6,7)57)52-46(56)51-40-15-16-41(39-14-9-8-13-38(39)40)62-36-17-18-48-43(29-36)50-34-26-33(27-37(28-34)59-5)45(55)49-19-20-60-23-24-61-22-21-58-4/h8-18,25-30H,19-24,31H2,1-7H3,(H,48,50)(H,49,55)(H2,51,52,56)
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n/an/a 34n/an/an/an/an/an/a



Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determining the leve...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM392694
PNG
(US10301288, Example 5)
Show SMILES COCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(OC)cc4)C(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C42H42N8O6/c1-6-28-23-29(40(51)43-19-20-55-22-21-53-4)25-30(24-28)45-41-44-18-17-39(48-41)56-37-16-15-35(33-9-7-8-10-34(33)37)46-42(52)47-38-26-36(27(2)3)49-50(38)31-11-13-32(54-5)14-12-31/h1,7-18,23-27H,19-22H2,2-5H3,(H,43,51)(H,44,45,48)(H2,46,47,52)
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Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM392698
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-(4-(dimethylamino)p...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(cc4)N(C)C)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C46H51N9O6/c1-8-31-27-32(43(56)47-21-22-59-25-26-60-24-23-58-7)29-33(28-31)49-44-48-20-19-42(52-44)61-39-18-17-38(36-11-9-10-12-37(36)39)50-45(57)51-41-30-40(46(2,3)4)53-55(41)35-15-13-34(14-16-35)54(5)6/h1,9-20,27-30H,21-26H2,2-7H3,(H,47,56)(H,48,49,52)(H2,50,51,57)
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Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM392692
PNG
(US10301288, Example 3)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(OC)cc4)C(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C44H46N8O7/c1-6-30-25-31(42(53)45-19-20-57-23-24-58-22-21-55-4)27-32(26-30)47-43-46-18-17-41(50-43)59-39-16-15-37(35-9-7-8-10-36(35)39)48-44(54)49-40-28-38(29(2)3)51-52(40)33-11-13-34(56-5)14-12-33/h1,7-18,25-29H,19-24H2,2-5H3,(H,45,53)(H,46,47,50)(H2,48,49,54)
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n/an/a 39n/an/an/an/an/an/a



Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determining the leve...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM392695
PNG
(US10301288, Example 12 | US10301288, Example 6)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C45H48N8O6/c1-7-31-26-32(42(54)46-20-21-57-24-25-58-23-22-56-6)28-33(27-31)48-43-47-19-18-41(51-43)59-38-17-16-37(35-10-8-9-11-36(35)38)49-44(55)50-40-29-39(45(3,4)5)52-53(40)34-14-12-30(2)13-15-34/h1,8-19,26-29H,20-25H2,2-6H3,(H,46,54)(H,47,48,51)(H2,49,50,55)
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n/an/a 42n/an/an/an/an/an/a



Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determining the leve...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM392693
PNG
(US10301288, Example 4)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)ccn2)cc(OC)c1
Show InChI InChI=1S/C44H49N7O7/c1-29(2)39-28-42(51(50-39)33-12-10-30(3)11-13-33)49-44(53)48-38-14-15-40(37-9-7-6-8-36(37)38)58-34-16-17-45-41(27-34)47-32-24-31(25-35(26-32)55-5)43(52)46-18-19-56-22-23-57-21-20-54-4/h6-17,24-29H,18-23H2,1-5H3,(H,45,47)(H,46,52)(H2,48,49,53)
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Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM392699
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-(4-(dimethylamino)p...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(cc4)N(C)C)C(C)(C)C)c4ccccc34)ccn2)cc(OC)c1
Show InChI InChI=1S/C46H54N8O7/c1-46(2,3)41-30-43(54(52-41)34-14-12-33(13-15-34)53(4)5)51-45(56)50-39-16-17-40(38-11-9-8-10-37(38)39)61-35-18-19-47-42(29-35)49-32-26-31(27-36(28-32)58-7)44(55)48-20-21-59-24-25-60-23-22-57-6/h8-19,26-30H,20-25H2,1-7H3,(H,47,49)(H,48,55)(H2,50,51,56)
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Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM392690
PNG
(3-Ethynyl-5-((4-((4-(3-(3-isopropyl-1-(p-tolyl)-1H...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C44H46N8O6/c1-6-31-25-32(42(53)45-19-20-56-23-24-57-22-21-55-5)27-33(26-31)47-43-46-18-17-41(50-43)58-39-16-15-37(35-9-7-8-10-36(35)39)48-44(54)49-40-28-38(29(2)3)51-52(40)34-13-11-30(4)12-14-34/h1,7-18,25-29H,19-24H2,2-5H3,(H,45,53)(H,46,47,50)(H2,48,49,54)
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Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM392693
PNG
(US10301288, Example 4)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)ccn2)cc(OC)c1
Show InChI InChI=1S/C44H49N7O7/c1-29(2)39-28-42(51(50-39)33-12-10-30(3)11-13-33)49-44(53)48-38-14-15-40(37-9-7-6-8-36(37)38)58-34-16-17-45-41(27-34)47-32-24-31(25-35(26-32)55-5)43(52)46-18-19-56-22-23-57-21-20-54-4/h6-17,24-29H,18-23H2,1-5H3,(H,45,47)(H,46,52)(H2,48,49,53)
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n/an/a 50n/an/an/an/an/an/a



Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determining the leve...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM392690
PNG
(3-Ethynyl-5-((4-((4-(3-(3-isopropyl-1-(p-tolyl)-1H...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C44H46N8O6/c1-6-31-25-32(42(53)45-19-20-56-23-24-57-22-21-55-5)27-33(26-31)47-43-46-18-17-41(50-43)58-39-16-15-37(35-9-7-8-10-36(35)39)48-44(54)49-40-28-38(29(2)3)51-52(40)34-13-11-30(4)12-14-34/h1,7-18,25-29H,19-24H2,2-5H3,(H,45,53)(H,46,47,50)(H2,48,49,54)
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n/an/a 52n/an/an/an/an/an/a



Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determining the leve...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM392704
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-(3-((dimethylphosph...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(nn4-c4cccc(CP(C)(C)=O)c4)C(C)(C)C)c4ccccc34)ccn2)cc(OC)c1
Show InChI InChI=1S/C47H56N7O8P/c1-47(2,3)42-30-44(54(53-42)35-12-10-11-32(25-35)31-63(6,7)57)52-46(56)51-40-15-16-41(39-14-9-8-13-38(39)40)62-36-17-18-48-43(29-36)50-34-26-33(27-37(28-34)59-5)45(55)49-19-20-60-23-24-61-22-21-58-4/h8-18,25-30H,19-24,31H2,1-7H3,(H,48,50)(H,49,55)(H2,51,52,56)
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Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM392703
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-(3-((dimethylphosph...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4cccc(CP(C)(C)=O)c4)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C47H53N8O7P/c1-8-32-26-34(44(56)48-20-21-60-24-25-61-23-22-59-5)29-35(27-32)50-45-49-19-18-43(53-45)62-40-17-16-39(37-14-9-10-15-38(37)40)51-46(57)52-42-30-41(47(2,3)4)54-55(42)36-13-11-12-33(28-36)31-63(6,7)58/h1,9-19,26-30H,20-25,31H2,2-7H3,(H,48,56)(H,49,50,53)(H2,51,52,57)
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n/an/a 88n/an/an/an/an/an/a



Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determining the leve...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM392696
PNG
(US10301288, Example 7)
Show SMILES COCCOCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C47H52N8O7/c1-7-33-28-34(44(56)48-20-21-59-24-25-61-27-26-60-23-22-58-6)30-35(29-33)50-45-49-19-18-43(53-45)62-40-17-16-39(37-10-8-9-11-38(37)40)51-46(57)52-42-31-41(47(3,4)5)54-55(42)36-14-12-32(2)13-15-36/h1,8-19,28-31H,20-27H2,2-6H3,(H,48,56)(H,49,50,53)(H2,51,52,57)
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n/an/a 88n/an/an/an/an/an/a



Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determining the leve...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM392695
PNG
(US10301288, Example 12 | US10301288, Example 6)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C45H48N8O6/c1-7-31-26-32(42(54)46-20-21-57-24-25-58-23-22-56-6)28-33(27-31)48-43-47-19-18-41(51-43)59-38-17-16-37(35-10-8-9-11-36(35)38)49-44(55)50-40-29-39(45(3,4)5)52-53(40)34-14-12-30(2)13-15-34/h1,8-19,26-29H,20-25H2,2-6H3,(H,46,54)(H,47,48,51)(H2,49,50,55)
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Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM392698
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-(4-(dimethylamino)p...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(cc4)N(C)C)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C46H51N9O6/c1-8-31-27-32(43(56)47-21-22-59-25-26-60-24-23-58-7)29-33(28-31)49-44-48-20-19-42(52-44)61-39-18-17-38(36-11-9-10-12-37(36)39)50-45(57)51-41-30-40(46(2,3)4)53-55(41)35-15-13-34(14-16-35)54(5)6/h1,9-20,27-30H,21-26H2,2-7H3,(H,47,56)(H,48,49,52)(H2,50,51,57)
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n/an/a 98n/an/an/an/an/an/a



Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determining the leve...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM392697
PNG
(US10301288, Example 8)
Show SMILES COCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C43H44N8O5/c1-7-29-24-30(40(52)44-20-21-55-23-22-54-6)26-31(25-29)46-41-45-19-18-39(49-41)56-36-17-16-35(33-10-8-9-11-34(33)36)47-42(53)48-38-27-37(43(3,4)5)50-51(38)32-14-12-28(2)13-15-32/h1,8-19,24-27H,20-23H2,2-6H3,(H,44,52)(H,45,46,49)(H2,47,48,53)
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n/an/a 104n/an/an/an/an/an/a



Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determining the leve...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM392699
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-(4-(dimethylamino)p...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(cc4)N(C)C)C(C)(C)C)c4ccccc34)ccn2)cc(OC)c1
Show InChI InChI=1S/C46H54N8O7/c1-46(2,3)41-30-43(54(52-41)34-14-12-33(13-15-34)53(4)5)51-45(56)50-39-16-17-40(38-11-9-8-10-37(38)39)61-35-18-19-47-42(29-35)49-32-26-31(27-36(28-32)58-7)44(55)48-20-21-59-24-25-60-23-22-57-6/h8-19,26-30H,20-25H2,1-7H3,(H,47,49)(H,48,55)(H2,50,51,56)
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n/an/a 110n/an/an/an/an/an/a



Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determining the leve...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM392697
PNG
(US10301288, Example 8)
Show SMILES COCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C43H44N8O5/c1-7-29-24-30(40(52)44-20-21-55-23-22-54-6)26-31(25-29)46-41-45-19-18-39(49-41)56-36-17-16-35(33-10-8-9-11-34(33)36)47-42(53)48-38-27-37(43(3,4)5)50-51(38)32-14-12-28(2)13-15-32/h1,8-19,24-27H,20-23H2,2-6H3,(H,44,52)(H,45,46,49)(H2,47,48,53)
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n/an/a 120n/an/an/an/an/an/a



Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM392702
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-(2,4-dimethoxypheny...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(OC)cc4OC)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C46H50N8O8/c1-8-30-25-31(43(55)47-19-20-60-23-24-61-22-21-57-5)27-32(26-30)49-44-48-18-17-42(52-44)62-38-16-14-36(34-11-9-10-12-35(34)38)50-45(56)51-41-29-40(46(2,3)4)53-54(41)37-15-13-33(58-6)28-39(37)59-7/h1,9-18,25-29H,19-24H2,2-7H3,(H,47,55)(H,48,49,52)(H2,50,51,56)
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Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM392696
PNG
(US10301288, Example 7)
Show SMILES COCCOCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C47H52N8O7/c1-7-33-28-34(44(56)48-20-21-59-24-25-61-27-26-60-23-22-58-6)30-35(29-33)50-45-49-19-18-43(53-45)62-40-17-16-39(37-10-8-9-11-38(37)40)51-46(57)52-42-31-41(47(3,4)5)54-55(42)36-14-12-32(2)13-15-36/h1,8-19,28-31H,20-27H2,2-6H3,(H,48,56)(H,49,50,53)(H2,51,52,57)
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Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM392690
PNG
(3-Ethynyl-5-((4-((4-(3-(3-isopropyl-1-(p-tolyl)-1H...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C44H46N8O6/c1-6-31-25-32(42(53)45-19-20-56-23-24-57-22-21-55-5)27-33(26-31)47-43-46-18-17-41(50-43)58-39-16-15-37(35-9-7-8-10-36(35)39)48-44(54)49-40-28-38(29(2)3)51-52(40)34-13-11-30(4)12-14-34/h1,7-18,25-29H,19-24H2,2-5H3,(H,45,53)(H,46,47,50)(H2,48,49,54)
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n/an/a 370n/an/an/an/an/an/a



Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM392702
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-(2,4-dimethoxypheny...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(OC)cc4OC)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C46H50N8O8/c1-8-30-25-31(43(55)47-19-20-60-23-24-61-22-21-57-5)27-32(26-30)49-44-48-18-17-42(52-44)62-38-16-14-36(34-11-9-10-12-35(34)38)50-45(56)51-41-29-40(46(2,3)4)53-54(41)37-15-13-33(58-6)28-39(37)59-7/h1,9-18,25-29H,19-24H2,2-7H3,(H,47,55)(H,48,49,52)(H2,50,51,56)
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n/an/a 370n/an/an/an/an/an/a



Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determining the leve...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM392703
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-(3-((dimethylphosph...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4cccc(CP(C)(C)=O)c4)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C47H53N8O7P/c1-8-32-26-34(44(56)48-20-21-60-24-25-61-23-22-59-5)29-35(27-32)50-45-49-19-18-43(53-45)62-40-17-16-39(37-14-9-10-15-38(37)40)51-46(57)52-42-30-41(47(2,3)4)54-55(42)36-13-11-12-33(28-36)31-63(6,7)58/h1,9-19,26-30H,20-25,31H2,2-7H3,(H,48,56)(H,49,50,53)(H2,51,52,57)
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Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM392705
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-(4-(dimethylamino)p...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(cc4)N(C)C)C(C)(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C45H53N9O7/c1-45(2,3)39-29-40(54(52-39)33-14-12-32(13-15-33)53(4)5)50-44(56)49-37-16-17-38(36-11-9-8-10-35(36)37)61-41-18-19-47-43(51-41)48-31-26-30(27-34(28-31)58-7)42(55)46-20-21-59-24-25-60-23-22-57-6/h8-19,26-29H,20-25H2,1-7H3,(H,46,55)(H,47,48,51)(H2,49,50,56)
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Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM392700
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-(4-(dimethylamino)p...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(cc4)N(C)C)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C#C
Show InChI InChI=1S/C47H52N8O6/c1-8-32-27-33(45(56)49-21-22-59-25-26-60-24-23-58-7)29-34(28-32)50-43-30-37(19-20-48-43)61-41-18-17-40(38-11-9-10-12-39(38)41)51-46(57)52-44-31-42(47(2,3)4)53-55(44)36-15-13-35(14-16-36)54(5)6/h1,9-20,27-31H,21-26H2,2-7H3,(H,48,50)(H,49,56)(H2,51,52,57)
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n/an/a 766n/an/an/an/an/an/a



Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determining the leve...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM392700
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-(4-(dimethylamino)p...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(cc4)N(C)C)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C#C
Show InChI InChI=1S/C47H52N8O6/c1-8-32-27-33(45(56)49-21-22-59-25-26-60-24-23-58-7)29-34(28-32)50-43-30-37(19-20-48-43)61-41-18-17-40(38-11-9-10-12-39(38)41)51-46(57)52-44-31-42(47(2,3)4)53-55(44)36-15-13-35(14-16-36)54(5)6/h1,9-20,27-31H,21-26H2,2-7H3,(H,48,50)(H,49,56)(H2,51,52,57)
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Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM392700
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-(4-(dimethylamino)p...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(cc4)N(C)C)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C#C
Show InChI InChI=1S/C47H52N8O6/c1-8-32-27-33(45(56)49-21-22-59-25-26-60-24-23-58-7)29-34(28-32)50-43-30-37(19-20-48-43)61-41-18-17-40(38-11-9-10-12-39(38)41)51-46(57)52-44-31-42(47(2,3)4)53-55(44)36-15-13-35(14-16-36)54(5)6/h1,9-20,27-31H,21-26H2,2-7H3,(H,48,50)(H,49,56)(H2,51,52,57)
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM392695
PNG
(US10301288, Example 12 | US10301288, Example 6)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C45H48N8O6/c1-7-31-26-32(42(54)46-20-21-57-24-25-58-23-22-56-6)28-33(27-31)48-43-47-19-18-41(51-43)59-38-17-16-37(35-10-8-9-11-36(35)38)49-44(55)50-40-29-39(45(3,4)5)52-53(40)34-14-12-30(2)13-15-34/h1,8-19,26-29H,20-25H2,2-6H3,(H,46,54)(H,47,48,51)(H2,49,50,55)
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Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM392696
PNG
(US10301288, Example 7)
Show SMILES COCCOCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C47H52N8O7/c1-7-33-28-34(44(56)48-20-21-59-24-25-61-27-26-60-23-22-58-6)30-35(29-33)50-45-49-19-18-43(53-45)62-40-17-16-39(37-10-8-9-11-38(37)40)51-46(57)52-42-31-41(47(3,4)5)54-55(42)36-14-12-32(2)13-15-36/h1,8-19,28-31H,20-27H2,2-6H3,(H,48,56)(H,49,50,53)(H2,51,52,57)
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM392702
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-(2,4-dimethoxypheny...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(OC)cc4OC)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C46H50N8O8/c1-8-30-25-31(43(55)47-19-20-60-23-24-61-22-21-57-5)27-32(26-30)49-44-48-18-17-42(52-44)62-38-16-14-36(34-11-9-10-12-35(34)38)50-45(56)51-41-29-40(46(2,3)4)53-54(41)37-15-13-33(58-6)28-39(37)59-7/h1,9-18,25-29H,19-24H2,2-7H3,(H,47,55)(H,48,49,52)(H2,50,51,56)
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM392697
PNG
(US10301288, Example 8)
Show SMILES COCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C43H44N8O5/c1-7-29-24-30(40(52)44-20-21-55-23-22-54-6)26-31(25-29)46-41-45-19-18-39(49-41)56-36-17-16-35(33-10-8-9-11-34(33)36)47-42(53)48-38-27-37(43(3,4)5)50-51(38)32-14-12-28(2)13-15-32/h1,8-19,24-27H,20-23H2,2-6H3,(H,44,52)(H,45,46,49)(H2,47,48,53)
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM392704
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-(3-((dimethylphosph...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(nn4-c4cccc(CP(C)(C)=O)c4)C(C)(C)C)c4ccccc34)ccn2)cc(OC)c1
Show InChI InChI=1S/C47H56N7O8P/c1-47(2,3)42-30-44(54(53-42)35-12-10-11-32(25-35)31-63(6,7)57)52-46(56)51-40-15-16-41(39-14-9-8-13-38(39)40)62-36-17-18-48-43(29-36)50-34-26-33(27-37(28-34)59-5)45(55)49-19-20-60-23-24-61-22-21-58-4/h8-18,25-30H,19-24,31H2,1-7H3,(H,48,50)(H,49,55)(H2,51,52,56)
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Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM392690
PNG
(3-Ethynyl-5-((4-((4-(3-(3-isopropyl-1-(p-tolyl)-1H...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C44H46N8O6/c1-6-31-25-32(42(53)45-19-20-56-23-24-57-22-21-55-5)27-33(26-31)47-43-46-18-17-41(50-43)58-39-16-15-37(35-9-7-8-10-36(35)39)48-44(54)49-40-28-38(29(2)3)51-52(40)34-13-11-30(4)12-14-34/h1,7-18,25-29H,19-24H2,2-5H3,(H,45,53)(H,46,47,50)(H2,48,49,54)
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Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM392693
PNG
(US10301288, Example 4)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)ccn2)cc(OC)c1
Show InChI InChI=1S/C44H49N7O7/c1-29(2)39-28-42(51(50-39)33-12-10-30(3)11-13-33)49-44(53)48-38-14-15-40(37-9-7-6-8-36(37)38)58-34-16-17-45-41(27-34)47-32-24-31(25-35(26-32)55-5)43(52)46-18-19-56-22-23-57-21-20-54-4/h6-17,24-29H,18-23H2,1-5H3,(H,45,47)(H,46,52)(H2,48,49,53)
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Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM392699
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-(4-(dimethylamino)p...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(cc4)N(C)C)C(C)(C)C)c4ccccc34)ccn2)cc(OC)c1
Show InChI InChI=1S/C46H54N8O7/c1-46(2,3)41-30-43(54(52-41)34-14-12-33(13-15-34)53(4)5)51-45(56)50-39-16-17-40(38-11-9-8-10-37(38)39)61-35-18-19-47-42(29-35)49-32-26-31(27-36(28-32)58-7)44(55)48-20-21-59-24-25-60-23-22-57-6/h8-19,26-30H,20-25H2,1-7H3,(H,47,49)(H,48,55)(H2,50,51,56)
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Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM392706
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-(4-methoxy-2-methyl...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(OC)cc4C)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C46H50N8O7/c1-8-31-26-32(43(55)47-19-20-59-23-24-60-22-21-57-6)28-33(27-31)49-44-48-18-17-42(52-44)61-39-16-14-37(35-11-9-10-12-36(35)39)50-45(56)51-41-29-40(46(3,4)5)53-54(41)38-15-13-34(58-7)25-30(38)2/h1,9-18,25-29H,19-24H2,2-7H3,(H,47,55)(H,48,49,52)(H2,50,51,56)
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Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM392698
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-(4-(dimethylamino)p...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(cc4)N(C)C)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C46H51N9O6/c1-8-31-27-32(43(56)47-21-22-59-25-26-60-24-23-58-7)29-33(28-31)49-44-48-20-19-42(52-44)61-39-18-17-38(36-11-9-10-12-37(36)39)50-45(57)51-41-30-40(46(2,3)4)53-55(41)35-15-13-34(14-16-35)54(5)6/h1,9-20,27-30H,21-26H2,2-7H3,(H,47,56)(H,48,49,52)(H2,50,51,57)
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Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM392700
PNG
(3-((4-((4-(3-(3-(tert-Butyl)-1-(4-(dimethylamino)p...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(cc4)N(C)C)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C#C
Show InChI InChI=1S/C47H52N8O6/c1-8-32-27-33(45(56)49-21-22-59-25-26-60-24-23-58-7)29-34(28-32)50-43-30-37(19-20-48-43)61-41-18-17-40(38-11-9-10-12-39(38)41)51-46(57)52-44-31-42(47(2,3)4)53-55(44)36-15-13-35(14-16-36)54(5)6/h1,9-20,27-31H,21-26H2,2-7H3,(H,48,50)(H,49,56)(H2,51,52,57)
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM392692
PNG
(US10301288, Example 3)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(OC)cc4)C(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C44H46N8O7/c1-6-30-25-31(42(53)45-19-20-57-23-24-58-22-21-55-4)27-32(26-30)47-43-46-18-17-41(50-43)59-39-16-15-37(35-9-7-8-10-36(35)39)48-44(54)49-40-28-38(29(2)3)51-52(40)33-11-13-34(56-5)14-12-33/h1,7-18,25-29H,19-24H2,2-5H3,(H,45,53)(H,46,47,50)(H2,48,49,54)
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM392695
PNG
(US10301288, Example 12 | US10301288, Example 6)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C45H48N8O6/c1-7-31-26-32(42(54)46-20-21-57-24-25-58-23-22-56-6)28-33(27-31)48-43-47-19-18-41(51-43)59-38-17-16-37(35-10-8-9-11-36(35)38)49-44(55)50-40-29-39(45(3,4)5)52-53(40)34-14-12-30(2)13-15-34/h1,8-19,26-29H,20-25H2,2-6H3,(H,46,54)(H,47,48,51)(H2,49,50,55)
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM392690
PNG
(3-Ethynyl-5-((4-((4-(3-(3-isopropyl-1-(p-tolyl)-1H...)
Show SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C44H46N8O6/c1-6-31-25-32(42(53)45-19-20-56-23-24-57-22-21-55-5)27-33(26-31)47-43-46-18-17-41(50-43)58-39-16-15-37(35-9-7-8-10-36(35)39)48-44(54)49-40-28-38(29(2)3)51-52(40)34-13-11-30(4)12-14-34/h1,7-18,25-29H,19-24H2,2-5H3,(H,45,53)(H,46,47,50)(H2,48,49,54)
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM392694
PNG
(US10301288, Example 5)
Show SMILES COCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(OC)cc4)C(C)C)c4ccccc34)n2)cc(c1)C#C
Show InChI InChI=1S/C42H42N8O6/c1-6-28-23-29(40(51)43-19-20-55-22-21-53-4)25-30(24-28)45-41-44-18-17-39(48-41)56-37-16-15-35(33-9-7-8-10-34(33)37)46-42(52)47-38-26-36(27(2)3)49-50(38)31-11-13-32(54-5)14-12-31/h1,7-18,23-27H,19-22H2,2-5H3,(H,43,51)(H,44,45,48)(H2,46,47,52)
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US10301288 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%