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Patent code US10301317

Compile Data Set for Download or QSAR

Found 373 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM272554
PNG
(US10065967, Example 20 | US10301317, Example 2 | U...)
Show SMILES C[C@@H](N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnc(C)c1)c1ccccc1
Show InChI InChI=1/C23H21N5O/c1-14-10-17(8-9-24-14)22-19-11-18-13-28(15(2)16-6-4-3-5-7-16)23(29)25-20(18)12-21(19)26-27-22/h3-12,15H,13H2,1-2H3,(H,25,29)(H,26,27)/t15-/s2
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318077
PNG
(US10301317, Example 33 | US9624228, Example 33)
Show SMILES CN1CCC[C@H](C1)N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnc(C)c1
Show InChI InChI=1/C21H24N6O/c1-13-8-14(5-6-22-13)20-17-9-15-11-27(16-4-3-7-26(2)12-16)21(28)23-18(15)10-19(17)24-25-20/h5-6,8-10,16H,3-4,7,11-12H2,1-2H3,(H,23,28)(H,24,25)/t16-/s2
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318080
PNG
(US10301317, Example 36 | US9624228, Example 36)
Show SMILES COc1ccc(cn1)-c1n[nH]c2cc3NC(=O)N(Cc4ccc(F)c(Cl)c4)Cc3cc12
Show InChI InChI=1S/C22H17ClFN5O2/c1-31-20-5-3-13(9-25-20)21-15-7-14-11-29(10-12-2-4-17(24)16(23)6-12)22(30)26-18(14)8-19(15)27-28-21/h2-9H,10-11H2,1H3,(H,26,30)(H,27,28)
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318085
PNG
(US10301317, Example 41 | US9624228, Example 41)
Show SMILES Cn1cc(ccc1=O)-c1n[nH]c2cc3NC(=O)N(Cc4ccc(F)c(Cl)c4)Cc3cc12
Show InChI InChI=1S/C22H17ClFN5O2/c1-28-10-13(3-5-20(28)30)21-15-7-14-11-29(9-12-2-4-17(24)16(23)6-12)22(31)25-18(14)8-19(15)26-27-21/h2-8,10H,9,11H2,1H3,(H,25,31)(H,26,27)
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318087
PNG
(US10301317, Example 43 | US9624228, Example 43)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(CCO)Cc3cc12
Show InChI InChI=1S/C17H17N5O2/c1-10-6-11(2-3-18-10)16-13-7-12-9-22(4-5-23)17(24)19-14(12)8-15(13)20-21-16/h2-3,6-8,23H,4-5,9H2,1H3,(H,19,24)(H,20,21)
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318088
PNG
(US10301317, Example 44 | US9624228, Example 44)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)C1CCOCC1
Show InChI InChI=1S/C20H21N5O2/c1-12-8-13(2-5-21-12)19-16-9-14-11-25(15-3-6-27-7-4-15)20(26)22-17(14)10-18(16)23-24-19/h2,5,8-10,15H,3-4,6-7,11H2,1H3,(H,22,26)(H,23,24)
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318089
PNG
(US10301317, Example 45 | US9624228, Example 45)
Show SMILES COCCOCCN1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnc(C)c1
Show InChI InChI=1S/C20H23N5O3/c1-13-9-14(3-4-21-13)19-16-10-15-12-25(5-6-28-8-7-27-2)20(26)22-17(15)11-18(16)23-24-19/h3-4,9-11H,5-8,12H2,1-2H3,(H,22,26)(H,23,24)
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318171
PNG
(US10301317, Example 127 | US9624228, Example 127)
Show SMILES Fc1cc(F)cc(CN2Cc3cc4c(n[nH]c4cc3NC2=O)-c2ccnnc2)c1
Show InChI InChI=1S/C20H14F2N6O/c21-14-3-11(4-15(22)6-14)9-28-10-13-5-16-18(7-17(13)25-20(28)29)26-27-19(16)12-1-2-23-24-8-12/h1-8H,9-10H2,(H,25,29)(H,26,27)
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318172
PNG
(US10301317, Example 128 | US9624228, Example 128)
Show SMILES O=C1Nc2cc3[nH]nc(-c4ccnnc4)c3cc2CN1Cc1cccc(c1)C#N
Show InChI InChI=1S/C21H15N7O/c22-9-13-2-1-3-14(6-13)11-28-12-16-7-17-19(8-18(16)25-21(28)29)26-27-20(17)15-4-5-23-24-10-15/h1-8,10H,11-12H2,(H,25,29)(H,26,27)
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318107
PNG
(US10301317, Example 165 | US9624228, Example 148 |...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(Cc2ccccc2)C1
Show InChI InChI=1/C27H28N6O/c1-18-12-20(9-10-28-18)26-23-13-21-16-33(27(34)29-24(21)14-25(23)30-31-26)22-8-5-11-32(17-22)15-19-6-3-2-4-7-19/h2-4,6-7,9-10,12-14,22H,5,8,11,15-17H2,1H3,(H,29,34)(H,30,31)/t22-/s2
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318200
PNG
(US10301317, Example 156 | US9624228, Example 156)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(Cc2cccc(Cl)c2)C1
Show InChI InChI=1/C27H27ClN6O/c1-17-10-19(7-8-29-17)26-23-12-20-15-34(27(35)30-24(20)13-25(23)31-32-26)22-6-3-9-33(16-22)14-18-4-2-5-21(28)11-18/h2,4-5,7-8,10-13,22H,3,6,9,14-16H2,1H3,(H,30,35)(H,31,32)/t22-/s2
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318205
PNG
(US10301317, Example 161 | US9624228, Example 161)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(Cc2cccnc2C(F)(F)F)C1
Show InChI InChI=1/C27H26F3N7O/c1-16-10-17(6-8-31-16)24-21-11-19-14-37(26(38)33-22(19)12-23(21)34-35-24)20-5-3-9-36(15-20)13-18-4-2-7-32-25(18)27(28,29)30/h2,4,6-8,10-12,20H,3,5,9,13-15H2,1H3,(H,33,38)(H,34,35)/t20-/s2
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318107
PNG
(US10301317, Example 165 | US9624228, Example 148 |...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(Cc2ccccc2)C1
Show InChI InChI=1/C27H28N6O/c1-18-12-20(9-10-28-18)26-23-13-21-16-33(27(34)29-24(21)14-25(23)30-31-26)22-8-5-11-32(17-22)15-19-6-3-2-4-7-19/h2-4,6-7,9-10,12-14,22H,5,8,11,15-17H2,1H3,(H,29,34)(H,30,31)/t22-/s2
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318218
PNG
(US10301317, Example 174 | US9624228, Example 174)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(C1)c1cccc(Cl)c1
Show InChI InChI=1/C26H25ClN6O/c1-16-10-17(7-8-28-16)25-22-11-18-14-33(26(34)29-23(18)13-24(22)30-31-25)21-6-3-9-32(15-21)20-5-2-4-19(27)12-20/h2,4-5,7-8,10-13,21H,3,6,9,14-15H2,1H3,(H,29,34)(H,30,31)/t21-/s2
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318231
PNG
(US10301317, Example 187 | US9624228, Example 187)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(Cc2cc(F)ccc2F)C1
Show InChI InChI=1/C27H26F2N6O/c1-16-9-17(6-7-30-16)26-22-11-19-14-35(27(36)31-24(19)12-25(22)32-33-26)21-3-2-8-34(15-21)13-18-10-20(28)4-5-23(18)29/h4-7,9-12,21H,2-3,8,13-15H2,1H3,(H,31,36)(H,32,33)/t21-/s2
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318237
PNG
(US10301317, Example 193 | US9624228, Example 193)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(CC(F)(F)F)C1
Show InChI InChI=1/C22H23F3N6O/c1-13-7-14(4-5-26-13)20-17-8-15-10-31(21(32)27-18(15)9-19(17)28-29-20)16-3-2-6-30(11-16)12-22(23,24)25/h4-5,7-9,16H,2-3,6,10-12H2,1H3,(H,27,32)(H,28,29)/t16-/s2
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318093
PNG
(US10301317, Example 49 | US9624228, Example 49)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCOC1
Show InChI InChI=1/C20H21N5O2/c1-12-7-13(4-5-21-12)19-16-8-14-10-25(15-3-2-6-27-11-15)20(26)22-17(14)9-18(16)23-24-19/h4-5,7-9,15H,2-3,6,10-11H2,1H3,(H,22,26)(H,23,24)/t15-/s2
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318098
PNG
(US10301317, Example 54 | US9624228, Example 54)
Show SMILES C[C@H](CO)N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnc(C)c1
Show InChI InChI=1/C18H19N5O2/c1-10-5-12(3-4-19-10)17-14-6-13-8-23(11(2)9-24)18(25)20-15(13)7-16(14)21-22-17/h3-7,11,24H,8-9H2,1-2H3,(H,20,25)(H,21,22)/t11-/s2
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318114
PNG
(US10301317, Example 70 | US9624228, Example 70)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)C1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C27H28N6O/c1-18-13-20(7-10-28-18)26-23-14-21-17-33(27(34)29-24(21)15-25(23)30-31-26)22-8-11-32(12-9-22)16-19-5-3-2-4-6-19/h2-7,10,13-15,22H,8-9,11-12,16-17H2,1H3,(H,29,34)(H,30,31)
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318148
PNG
(US10301317, Example 104 | US9624228, Example 104)
Show SMILES COc1ncc(cn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(Cc2ccccc2)C1
Show InChI InChI=1/C26H27N7O2/c1-35-25-27-12-19(13-28-25)24-21-10-18-15-33(26(34)29-22(18)11-23(21)30-31-24)20-8-5-9-32(16-20)14-17-6-3-2-4-7-17/h2-4,6-7,10-13,20H,5,8-9,14-16H2,1H3,(H,29,34)(H,30,31)/t20-/s2
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM393184
PNG
(US10301317, Example 197)
Show SMILES CC(N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnc(C)c1)c1ccc(F)cc1
Show InChI InChI=1/C23H20FN5O/c1-13-9-16(7-8-25-13)22-19-10-17-12-29(14(2)15-3-5-18(24)6-4-15)23(30)26-20(17)11-21(19)27-28-22/h3-11,14H,12H2,1-2H3,(H,26,30)(H,27,28)
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318249
PNG
(US10301317, Example 205 | US9624228, Example 205)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)C1CCCC1
Show InChI InChI=1S/C20H21N5O/c1-12-8-13(6-7-21-12)19-16-9-14-11-25(15-4-2-3-5-15)20(26)22-17(14)10-18(16)23-24-19/h6-10,15H,2-5,11H2,1H3,(H,22,26)(H,23,24)
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318261
PNG
(US10301317, Example 217 | US9624228, Example 217)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc4ccccc4Cl)Cc3cc12
Show InChI InChI=1S/C22H18ClN5O/c1-13-8-14(6-7-24-13)21-17-9-16-12-28(11-15-4-2-3-5-18(15)23)22(29)25-19(16)10-20(17)26-27-21/h2-10H,11-12H2,1H3,(H,25,29)(H,26,27)
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318263
PNG
(US10301317, Example 219 | US9624228, Example 219)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)C1CCOC(C)(C)C1
Show InChI InChI=1/C22H25N5O2/c1-13-8-14(4-6-23-13)20-17-9-15-12-27(16-5-7-29-22(2,3)11-16)21(28)24-18(15)10-19(17)25-26-20/h4,6,8-10,16H,5,7,11-12H2,1-3H3,(H,24,28)(H,25,26)
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318287
PNG
(US10301317, Example 244 | US9624228, Example 244)
Show SMILES Cc1cc(cc(C)n1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(CC(F)(F)F)C1
Show InChI InChI=1/C23H25F3N6O/c1-13-6-15(7-14(2)27-13)21-18-8-16-10-32(22(33)28-19(16)9-20(18)29-30-21)17-4-3-5-31(11-17)12-23(24,25)26/h6-9,17H,3-5,10-12H2,1-2H3,(H,28,33)(H,29,30)/t17-/s2
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318288
PNG
(US10301317, Example 245 | US9624228, Example 245)
Show SMILES Cc1ccc(CN2CCC[C@H](C2)N2Cc3cc4c(n[nH]c4cc3NC2=O)-c2ccnc(C)c2)s1
Show InChI InChI=1/C26H28N6OS/c1-16-10-18(7-8-27-16)25-22-11-19-13-32(26(33)28-23(19)12-24(22)29-30-25)20-4-3-9-31(14-20)15-21-6-5-17(2)34-21/h5-8,10-12,20H,3-4,9,13-15H2,1-2H3,(H,28,33)(H,29,30)/t20-/s2
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318302
PNG
(US10301317, Example 259 | US9624228, Example 259)
Show SMILES Cn1cc(cn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCN(CC(F)(F)F)C1
Show InChI InChI=1/C19H20F3N7O/c1-27-7-12(6-23-27)17-14-4-11-8-29(13-2-3-28(9-13)10-19(20,21)22)18(30)24-15(11)5-16(14)25-26-17/h4-7,13H,2-3,8-10H2,1H3,(H,24,30)(H,25,26)/t13-/s2
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318389
PNG
(US10301317, Example 347 | US9624228, Example 347)
Show SMILES CC(c1ccccc1)c1cc2cc3c(n[nH]c3cc2[nH]c1=O)-c1ccc(=O)n(C)c1
Show InChI InChI=1/C24H20N4O2/c1-14(15-6-4-3-5-7-15)18-10-17-11-19-21(12-20(17)25-24(18)30)26-27-23(19)16-8-9-22(29)28(2)13-16/h3-14H,1-2H3,(H,25,30)(H,26,27)
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318390
PNG
(US10301317, Example 348 | US9624228, Example 348)
Show SMILES COc1ncc(cn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CN(CC(F)(F)F)C[C@H]1c1ccccc1
Show InChI InChI=1/C26H24F3N7O2/c1-38-24-30-9-17(10-31-24)23-18-7-16-11-36(25(37)32-20(16)8-21(18)33-34-23)22-13-35(14-26(27,28)29)12-19(22)15-5-3-2-4-6-15/h2-10,19,22H,11-14H2,1H3,(H,32,37)(H,33,34)/t19-,22+/s2
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318418
PNG
(US10301317, Example 376 | US9624228, Example 376)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CN(CCO)C[C@H]1c1ccccc1
Show InChI InChI=1/C27H28N6O2/c1-17-11-19(7-8-28-17)26-21-12-20-14-33(27(35)29-23(20)13-24(21)30-31-26)25-16-32(9-10-34)15-22(25)18-5-3-2-4-6-18/h2-8,11-13,22,25,34H,9-10,14-16H2,1H3,(H,29,35)(H,30,31)/t22-,25+/s2
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318332
PNG
(US10301317, Example 289 | US9624228, Example 289)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3[nH]c(=O)c(cc3cc12)C1CCCC1
Show InChI InChI=1S/C21H20N4O/c1-12-8-14(6-7-22-12)20-17-10-15-9-16(13-4-2-3-5-13)21(26)23-18(15)11-19(17)24-25-20/h6-11,13H,2-5H2,1H3,(H,23,26)(H,24,25)
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318322
PNG
(US10301317, Example 297 | US9624228, Example 279 |...)
Show SMILES CC(C)N1C[C@H]([C@@H](C1)c1ccccc1)N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnc(C)c1
Show InChI InChI=1/C28H30N6O/c1-17(2)33-15-23(19-7-5-4-6-8-19)26(16-33)34-14-21-12-22-25(13-24(21)30-28(34)35)31-32-27(22)20-9-10-29-18(3)11-20/h4-13,17,23,26H,14-16H2,1-3H3,(H,30,35)(H,31,32)/t23-,26+/s2
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318053
PNG
(US10301317, Example 9 | US9624228, Example 9)
Show SMILES COc1ncccc1CN1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnc(C)c1
Show InChI InChI=1S/C22H20N6O2/c1-13-8-14(5-7-23-13)20-17-9-16-12-28(11-15-4-3-6-24-21(15)30-2)22(29)25-18(16)10-19(17)26-27-20/h3-10H,11-12H2,1-2H3,(H,25,29)(H,26,27)
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318054
PNG
(US10301317, Example 10 | US9624228, Example 10)
Show SMILES COc1ccc(CN2Cc3cc4c(n[nH]c4cc3NC2=O)-c2ccnc(C)c2)cc1
Show InChI InChI=1S/C23H21N5O2/c1-14-9-16(7-8-24-14)22-19-10-17-13-28(12-15-3-5-18(30-2)6-4-15)23(29)25-20(17)11-21(19)26-27-22/h3-11H,12-13H2,1-2H3,(H,25,29)(H,26,27)
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318062
PNG
(US10301317, Example 18 | US9624228, Example 18)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(CCc4ccc(F)cc4)Cc3cc12
Show InChI InChI=1S/C23H20FN5O/c1-14-10-16(6-8-25-14)22-19-11-17-13-29(9-7-15-2-4-18(24)5-3-15)23(30)26-20(17)12-21(19)27-28-22/h2-6,8,10-12H,7,9,13H2,1H3,(H,26,30)(H,27,28)
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318066
PNG
(US10301317, Example 22 | US9624228, Example 22)
Show SMILES CC(c1ccccc1)c1cc2cc3c(n[nH]c3cc2[nH]c1=O)-c1ccnc(C)c1
Show InChI InChI=1/C24H20N4O/c1-14-10-17(8-9-25-14)23-20-12-18-11-19(15(2)16-6-4-3-5-7-16)24(29)26-21(18)13-22(20)27-28-23/h3-13,15H,1-2H3,(H,26,29)(H,27,28)
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318075
PNG
(US10301317, Example 31 | US9624228, Example 31)
Show SMILES Cn1cc(cn1)-c1n[nH]c2cc3NC(=O)N(Cc4ccc(F)c(Cl)c4)Cc3cc12
Show InChI InChI=1S/C20H16ClFN6O/c1-27-9-13(7-23-27)19-14-5-12-10-28(8-11-2-3-16(22)15(21)4-11)20(29)24-17(12)6-18(14)25-26-19/h2-7,9H,8,10H2,1H3,(H,24,29)(H,25,26)
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318187
PNG
(US10301317, Example 143 | US9624228, Example 143)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(Cc2c(F)cccc2F)C1
Show InChI InChI=1/C27H26F2N6O/c1-16-10-17(7-8-30-16)26-20-11-18-13-35(27(36)31-24(18)12-25(20)32-33-26)19-4-3-9-34(14-19)15-21-22(28)5-2-6-23(21)29/h2,5-8,10-12,19H,3-4,9,13-15H2,1H3,(H,31,36)(H,32,33)/t19-/s2
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318189
PNG
(US10301317, Example 145 | US9624228, Example 145)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(CCc2ccccc2)C1
Show InChI InChI=1/C28H30N6O/c1-19-14-21(9-11-29-19)27-24-15-22-17-34(28(35)30-25(22)16-26(24)31-32-27)23-8-5-12-33(18-23)13-10-20-6-3-2-4-7-20/h2-4,6-7,9,11,14-16,23H,5,8,10,12-13,17-18H2,1H3,(H,30,35)(H,31,32)/t23-/s2
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318195
PNG
(US10301317, Example 151 | US9624228, Example 151)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(Cc2ccc(F)cc2)C1
Show InChI InChI=1/C27H27FN6O/c1-17-11-19(8-9-29-17)26-23-12-20-15-34(27(35)30-24(20)13-25(23)31-32-26)22-3-2-10-33(16-22)14-18-4-6-21(28)7-5-18/h4-9,11-13,22H,2-3,10,14-16H2,1H3,(H,30,35)(H,31,32)/t22-/s2
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318210
PNG
(US10301317, Example 166 | US9624228, Example 166)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(Cc2cncnc2)C1
Show InChI InChI=1/C25H26N8O/c1-16-7-18(4-5-28-16)24-21-8-19-13-33(25(34)29-22(19)9-23(21)30-31-24)20-3-2-6-32(14-20)12-17-10-26-15-27-11-17/h4-5,7-11,15,20H,2-3,6,12-14H2,1H3,(H,29,34)(H,30,31)/t20-/s2
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318220
PNG
(US10301317, Example 176 | US9624228, Example 176)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(CCNCc4cccc(Cl)c4)Cc3cc12
Show InChI InChI=1S/C24H23ClN6O/c1-15-9-17(5-6-27-15)23-20-11-18-14-31(24(32)28-21(18)12-22(20)29-30-23)8-7-26-13-16-3-2-4-19(25)10-16/h2-6,9-12,26H,7-8,13-14H2,1H3,(H,28,32)(H,29,30)
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318097
PNG
(US10301317, Example 53 | US9624228, Example 53)
Show SMILES CC(C)CC(C)N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnc(C)c1
Show InChI InChI=1/C21H25N5O/c1-12(2)7-14(4)26-11-16-9-17-19(10-18(16)23-21(26)27)24-25-20(17)15-5-6-22-13(3)8-15/h5-6,8-10,12,14H,7,11H2,1-4H3,(H,23,27)(H,24,25)
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318105
PNG
(US10301317, Example 61 | US9624228, Example 61)
Show SMILES Clc1cccc(CN2Cc3cc4c(n[nH]c4cc3NC2=O)-c2ccc(=O)[nH]c2)c1
Show InChI InChI=1S/C21H16ClN5O2/c22-15-3-1-2-12(6-15)10-27-11-14-7-16-18(8-17(14)24-21(27)29)25-26-20(16)13-4-5-19(28)23-9-13/h1-9H,10-11H2,(H,23,28)(H,24,29)(H,25,26)
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318107
PNG
(US10301317, Example 165 | US9624228, Example 148 |...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(Cc2ccccc2)C1
Show InChI InChI=1/C27H28N6O/c1-18-12-20(9-10-28-18)26-23-13-21-16-33(27(34)29-24(21)14-25(23)30-31-26)22-8-5-11-32(17-22)15-19-6-3-2-4-7-19/h2-4,6-7,9-10,12-14,22H,5,8,11,15-17H2,1H3,(H,29,34)(H,30,31)/t22-/s2
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318123
PNG
(US10301317, Example 79 | US9624228, Example 79)
Show SMILES COc1ccc(cn1)-c1n[nH]c2cc3NC(=O)N(CCc4ccc(F)cc4)Cc3cc12
Show InChI InChI=1S/C23H20FN5O2/c1-31-21-7-4-15(12-25-21)22-18-10-16-13-29(9-8-14-2-5-17(24)6-3-14)23(30)26-19(16)11-20(18)27-28-22/h2-7,10-12H,8-9,13H2,1H3,(H,26,30)(H,27,28)
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318124
PNG
(US10301317, Example 80 | US9624228, Example 80)
Show SMILES COc1ncc(cn1)-c1n[nH]c2cc3NC(=O)N(CCc4ccc(F)cc4)Cc3cc12
Show InChI InChI=1S/C22H19FN6O2/c1-31-21-24-10-15(11-25-21)20-17-8-14-12-29(7-6-13-2-4-16(23)5-3-13)22(30)26-18(14)9-19(17)27-28-20/h2-5,8-11H,6-7,12H2,1H3,(H,26,30)(H,27,28)
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318129
PNG
(US10301317, Example 85 | US9624228, Example 85)
Show SMILES COc1ccc(cn1)-c1n[nH]c2cc3NC(=O)N(CCc4cccc(Cl)c4)Cc3cc12
Show InChI InChI=1S/C23H20ClN5O2/c1-31-21-6-5-15(12-25-21)22-18-10-16-13-29(8-7-14-3-2-4-17(24)9-14)23(30)26-19(16)11-20(18)27-28-22/h2-6,9-12H,7-8,13H2,1H3,(H,26,30)(H,27,28)
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318143
PNG
(US10301317, Example 99 | US9624228, Example 99)
Show SMILES COc1ncc(cn1)-c1n[nH]c2cc3NC(=O)N(Cc4ccc(F)cc4F)Cc3cc12
Show InChI InChI=1S/C21H16F2N6O2/c1-31-20-24-7-13(8-25-20)19-15-4-12-10-29(9-11-2-3-14(22)5-16(11)23)21(30)26-17(12)6-18(15)27-28-19/h2-8H,9-10H2,1H3,(H,26,30)(H,27,28)
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM318146
PNG
(US10301317, Example 102 | US9624228, Example 102)
Show SMILES COc1ncc(cn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(Cc2c(F)cccc2F)C1
Show InChI InChI=1/C26H25F2N7O2/c1-37-25-29-10-16(11-30-25)24-18-8-15-12-35(26(36)31-22(15)9-23(18)32-33-24)17-4-3-7-34(13-17)14-19-20(27)5-2-6-21(19)28/h2,5-6,8-11,17H,3-4,7,12-14H2,1H3,(H,31,36)(H,32,33)/t17-/s2
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KURA ONCOLOGY, INC.

US Patent


Assay Description
The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...


US Patent US10301317 (2019)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%