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Patent code US10301323

Compile Data Set for Download or QSAR
Found 183 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375737
PNG
(US10301323, Compound B5 | US9908899, Compound B5)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2cc(F)cc(Cl)c2)c1
Show InChI InChI=1S/C20H18ClFN4O2/c21-15-9-16(22)11-17(10-15)28-8-7-26-13-14(12-24-26)5-6-20(27)25-19-4-2-1-3-18(19)23/h1-6,9-13H,7-8,23H2,(H,25,27)/b6-5+
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375739
PNG
(US10301323, Compound D4 | US9908899, Compound D4)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(Cc2ccccc2)c1
Show InChI InChI=1S/C19H18N4O/c20-17-8-4-5-9-18(17)22-19(24)11-10-16-12-21-23(14-16)13-15-6-2-1-3-7-15/h1-12,14H,13,20H2,(H,22,24)/b11-10+
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375742
PNG
(US10301323, Compound D14 | US9908899, Compound D14)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOCc2ccccc2)c1
Show InChI InChI=1S/C21H22N4O2/c22-19-8-4-5-9-20(19)24-21(26)11-10-18-14-23-25(15-18)12-13-27-16-17-6-2-1-3-7-17/h1-11,14-15H,12-13,16,22H2,(H,24,26)/b11-10+
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375745
PNG
(US10301323, Compound D12 | US9908899, Compound D12)
Show SMILES CN(CCCn1cc(\C=C\C(=O)Nc2ccccc2N)cn1)c1ccccc1
Show InChI InChI=1S/C22H25N5O/c1-26(19-8-3-2-4-9-19)14-7-15-27-17-18(16-24-27)12-13-22(28)25-21-11-6-5-10-20(21)23/h2-6,8-13,16-17H,7,14-15,23H2,1H3,(H,25,28)/b13-12+
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375765
PNG
(US10301323, Compound A5 | US9908899, Compound A5)
Show SMILES Cc1cc(\C=C\C(=O)Nc2ccccc2N)on1
Show InChI InChI=1S/C13H13N3O2/c1-9-8-10(18-16-9)6-7-13(17)15-12-5-3-2-4-11(12)14/h2-8H,14H2,1H3,(H,15,17)/b7-6+
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375766
PNG
((E)-N-(2-aminophenyl)-3-(2-cinnamylthiazol-4-yl)ac...)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1csc(C\C=C\c2ccccc2)n1
Show InChI InChI=1S/C21H19N3OS/c22-18-10-4-5-11-19(18)24-20(25)14-13-17-15-26-21(23-17)12-6-9-16-7-2-1-3-8-16/h1-11,13-15H,12,22H2,(H,24,25)/b9-6+,14-13+
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375767
PNG
(US10301323, Compound F1 | US9908899, Compound F1)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CCN(CC2)C(=O)OCc2ccccc2)cc1
Show InChI InChI=1S/C27H27N3O3/c28-24-8-4-5-9-25(24)29-26(31)23-12-10-20(11-13-23)18-21-14-16-30(17-15-21)27(32)33-19-22-6-2-1-3-7-22/h1-13,18H,14-17,19,28H2,(H,29,31)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375724
PNG
(US10301323, Compound D1 | US9908899, Compound D1)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(C\C=C\c2ccccc2)c1
Show InChI InChI=1S/C21H20N4O/c22-19-10-4-5-11-20(19)24-21(26)13-12-18-15-23-25(16-18)14-6-9-17-7-2-1-3-8-17/h1-13,15-16H,14,22H2,(H,24,26)/b9-6+,13-12+
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375724
PNG
(US10301323, Compound D1 | US9908899, Compound D1)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(C\C=C\c2ccccc2)c1
Show InChI InChI=1S/C21H20N4O/c22-19-10-4-5-11-20(19)24-21(26)13-12-18-15-23-25(16-18)14-6-9-17-7-2-1-3-8-17/h1-13,15-16H,14,22H2,(H,24,26)/b9-6+,13-12+
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375734
PNG
(US10301323, Compound B4 | US9908899, Compound B4)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2ccc(cc2)C(F)(F)F)c1
Show InChI InChI=1S/C21H19F3N4O2/c22-21(23,24)16-6-8-17(9-7-16)30-12-11-28-14-15(13-26-28)5-10-20(29)27-19-4-2-1-3-18(19)25/h1-10,13-14H,11-12,25H2,(H,27,29)/b10-5+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375735
PNG
(US10301323, Compound B3 | US9908899, Compound B3)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2cc(F)cc(F)c2)c1
Show InChI InChI=1S/C20H18F2N4O2/c21-15-9-16(22)11-17(10-15)28-8-7-26-13-14(12-24-26)5-6-20(27)25-19-4-2-1-3-18(19)23/h1-6,9-13H,7-8,23H2,(H,25,27)/b6-5+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375740
PNG
(US10301323, Compound D7 | US9908899, Compound D7)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCc2ccccc2)c1
Show InChI InChI=1S/C20H20N4O/c21-18-8-4-5-9-19(18)23-20(25)11-10-17-14-22-24(15-17)13-12-16-6-2-1-3-7-16/h1-11,14-15H,12-13,21H2,(H,23,25)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375744
PNG
(US10301323, Compound D5 | US9908899, Compound D5)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(Cc2ccc(F)cc2)c1
Show InChI InChI=1S/C19H17FN4O/c20-16-8-5-14(6-9-16)12-24-13-15(11-22-24)7-10-19(25)23-18-4-2-1-3-17(18)21/h1-11,13H,12,21H2,(H,23,25)/b10-7+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375751
PNG
(US10301323, Compound A8 | US9908899, Compound A8)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cc2ccccn2n1
Show InChI InChI=1S/C16H14N4O/c17-14-6-1-2-7-15(14)18-16(21)9-8-12-11-13-5-3-4-10-20(13)19-12/h1-11H,17H2,(H,18,21)/b9-8+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM393052
PNG
(US10301323, Compound F17)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CN(Cc3ccccc3)C2)cc1
Show InChI InChI=1S/C24H23N3O/c25-22-8-4-5-9-23(22)26-24(28)21-12-10-18(11-13-21)14-20-16-27(17-20)15-19-6-2-1-3-7-19/h1-14H,15-17,25H2,(H,26,28)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM393054
PNG
(US10301323, Compound F18)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CN(Cc3cccnc3)C2)cc1
Show InChI InChI=1S/C23H22N4O/c24-21-5-1-2-6-22(21)26-23(28)20-9-7-17(8-10-20)12-19-15-27(16-19)14-18-4-3-11-25-13-18/h1-13H,14-16,24H2,(H,26,28)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM393056
PNG
(US10301323, Compound F20)
Show SMILES Nc1cc(F)ccc1NC(=O)c1ccc(C=C2CN(CC3CC3)C2)cc1
Show InChI InChI=1S/C21H22FN3O/c22-18-7-8-20(19(23)10-18)24-21(26)17-5-3-14(4-6-17)9-16-12-25(13-16)11-15-1-2-15/h3-10,15H,1-2,11-13,23H2,(H,24,26)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375767
PNG
(US10301323, Compound F1 | US9908899, Compound F1)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CCN(CC2)C(=O)OCc2ccccc2)cc1
Show InChI InChI=1S/C27H27N3O3/c28-24-8-4-5-9-25(24)29-26(31)23-12-10-20(11-13-23)18-21-14-16-30(17-15-21)27(32)33-19-22-6-2-1-3-7-22/h1-13,18H,14-17,19,28H2,(H,29,31)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375771
PNG
(US10301323, Compound F5 | US9908899, Compound F5)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CN(Cc3ccc4cc[nH]c4c3)C2)c(Cl)c1
Show InChI InChI=1S/C26H23ClN4O/c27-22-13-21(26(32)30-24-4-2-1-3-23(24)28)8-7-20(22)11-18-15-31(16-18)14-17-5-6-19-9-10-29-25(19)12-17/h1-13,29H,14-16,28H2,(H,30,32)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375773
PNG
(US10301323, Compound F7 | US9908899, Compound F7)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CCN(Cc3cccnc3)CC2)c(Cl)c1
Show InChI InChI=1S/C25H25ClN4O/c26-22-15-21(25(31)29-24-6-2-1-5-23(24)27)8-7-20(22)14-18-9-12-30(13-10-18)17-19-4-3-11-28-16-19/h1-8,11,14-16H,9-10,12-13,17,27H2,(H,29,31)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375728
PNG
(US10301323, Compound B6 | US9908899, Compound B6)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2ccc(F)cc2)c1
Show InChI InChI=1S/C20H19FN4O2/c21-16-6-8-17(9-7-16)27-12-11-25-14-15(13-23-25)5-10-20(26)24-19-4-2-1-3-18(19)22/h1-10,13-14H,11-12,22H2,(H,24,26)/b10-5+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375728
PNG
(US10301323, Compound B6 | US9908899, Compound B6)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2ccc(F)cc2)c1
Show InChI InChI=1S/C20H19FN4O2/c21-16-6-8-17(9-7-16)27-12-11-25-14-15(13-23-25)5-10-20(26)24-19-4-2-1-3-18(19)22/h1-10,13-14H,11-12,22H2,(H,24,26)/b10-5+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375734
PNG
(US10301323, Compound B4 | US9908899, Compound B4)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2ccc(cc2)C(F)(F)F)c1
Show InChI InChI=1S/C21H19F3N4O2/c22-21(23,24)16-6-8-17(9-7-16)30-12-11-28-14-15(13-26-28)5-10-20(29)27-19-4-2-1-3-18(19)25/h1-10,13-14H,11-12,25H2,(H,27,29)/b10-5+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375743
PNG
(US10301323, Compound D11 | US9908899, Compound D11)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CC\C=C\c2ccccc2)c1
Show InChI InChI=1S/C22H22N4O/c23-20-11-4-5-12-21(20)25-22(27)14-13-19-16-24-26(17-19)15-7-6-10-18-8-2-1-3-9-18/h1-6,8-14,16-17H,7,15,23H2,(H,25,27)/b10-6+,14-13+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375743
PNG
(US10301323, Compound D11 | US9908899, Compound D11)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CC\C=C\c2ccccc2)c1
Show InChI InChI=1S/C22H22N4O/c23-20-11-4-5-12-21(20)25-22(27)14-13-19-16-24-26(17-19)15-7-6-10-18-8-2-1-3-9-18/h1-6,8-14,16-17H,7,15,23H2,(H,25,27)/b10-6+,14-13+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375744
PNG
(US10301323, Compound D5 | US9908899, Compound D5)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(Cc2ccc(F)cc2)c1
Show InChI InChI=1S/C19H17FN4O/c20-16-8-5-14(6-9-16)12-24-13-15(11-22-24)7-10-19(25)23-18-4-2-1-3-17(18)21/h1-11,13H,12,21H2,(H,23,25)/b10-7+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375747
PNG
(US10301323, Compound D15 | US9908899, Compound D15)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCCOc2ccccc2)c1
Show InChI InChI=1S/C21H22N4O2/c22-19-9-4-5-10-20(19)24-21(26)12-11-17-15-23-25(16-17)13-6-14-27-18-7-2-1-3-8-18/h1-5,7-12,15-16H,6,13-14,22H2,(H,24,26)/b12-11+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375750
PNG
(US10301323, Compound A6 | US9908899, Compound A6)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnc2ccccn12
Show InChI InChI=1S/C16H14N4O/c17-13-5-1-2-6-14(13)19-16(21)9-8-12-11-18-15-7-3-4-10-20(12)15/h1-11H,17H2,(H,19,21)/b9-8+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375755
PNG
(US10301323, Compound A2 | US9908899, Compound A2)
Show SMILES Cn1cc(\C=C\C(=O)Nc2ccccc2N)cn1
Show InChI InChI=1S/C13H14N4O/c1-17-9-10(8-15-17)6-7-13(18)16-12-5-3-2-4-11(12)14/h2-9H,14H2,1H3,(H,16,18)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM393046
PNG
(US10301323, Compound F11)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2COC2)c(Cl)c1
Show InChI InChI=1S/C17H15ClN2O2/c18-14-8-13(6-5-12(14)7-11-9-22-10-11)17(21)20-16-4-2-1-3-15(16)19/h1-8H,9-10,19H2,(H,20,21)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM393050
PNG
(US10301323, Compound F15)
Show SMILES CC(C)(O)CN1CCC(CC1)=Cc1ccc(cc1)C(=O)Nc1ccccc1N
Show InChI InChI=1S/C23H29N3O2/c1-23(2,28)16-26-13-11-18(12-14-26)15-17-7-9-19(10-8-17)22(27)25-21-6-4-3-5-20(21)24/h3-10,15,28H,11-14,16,24H2,1-2H3,(H,25,27)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM393050
PNG
(US10301323, Compound F15)
Show SMILES CC(C)(O)CN1CCC(CC1)=Cc1ccc(cc1)C(=O)Nc1ccccc1N
Show InChI InChI=1S/C23H29N3O2/c1-23(2,28)16-26-13-11-18(12-14-26)15-17-7-9-19(10-8-17)22(27)25-21-6-4-3-5-20(21)24/h3-10,15,28H,11-14,16,24H2,1-2H3,(H,25,27)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM393054
PNG
(US10301323, Compound F18)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CN(Cc3cccnc3)C2)cc1
Show InChI InChI=1S/C23H22N4O/c24-21-5-1-2-6-22(21)26-23(28)20-9-7-17(8-10-20)12-19-15-27(16-19)14-18-4-3-11-25-13-18/h1-13H,14-16,24H2,(H,26,28)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375758
PNG
(US10301323, Compound C3 | US9908899, Compound C3)
Show SMILES Cn1cc(\C=C\C(=O)Nc2cc(F)ccc2N)cn1
Show InChI InChI=1S/C13H13FN4O/c1-18-8-9(7-16-18)2-5-13(19)17-12-6-10(14)3-4-11(12)15/h2-8H,15H2,1H3,(H,17,19)/b5-2+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375759
PNG
(US10301323, Compound A11 | US9908899, Compound A11)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(c1)-c1ccccc1
Show InChI InChI=1S/C18H16N4O/c19-16-8-4-5-9-17(16)21-18(23)11-10-14-12-20-22(13-14)15-6-2-1-3-7-15/h1-13H,19H2,(H,21,23)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375766
PNG
((E)-N-(2-aminophenyl)-3-(2-cinnamylthiazol-4-yl)ac...)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1csc(C\C=C\c2ccccc2)n1
Show InChI InChI=1S/C21H19N3OS/c22-18-10-4-5-11-19(18)24-20(25)14-13-17-15-26-21(23-17)12-6-9-16-7-2-1-3-8-16/h1-11,13-15H,12,22H2,(H,24,25)/b9-6+,14-13+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375769
PNG
(US10301323, Compound F3 | US9908899, Compound F3)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CN(Cc3ccc4cc[nH]c4c3)C2)cc1
Show InChI InChI=1S/C26H24N4O/c27-23-3-1-2-4-24(23)29-26(31)22-9-5-18(6-10-22)13-20-16-30(17-20)15-19-7-8-21-11-12-28-25(21)14-19/h1-14,28H,15-17,27H2,(H,29,31)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM393043
PNG
(US10301323, Compound F8)
Show SMILES CN1C2CCC1CC(C2)=Cc1ccc(cc1Cl)C(=O)Nc1ccccc1N
Show InChI InChI=1S/C22H24ClN3O/c1-26-17-8-9-18(26)12-14(11-17)10-15-6-7-16(13-19(15)23)22(27)25-21-5-3-2-4-20(21)24/h2-7,10,13,17-18H,8-9,11-12,24H2,1H3,(H,25,27)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375726
PNG
(US10301323, Compound D3 | US9908899, Compound D3)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2ccccc2)c1
Show InChI InChI=1S/C20H20N4O2/c21-18-8-4-5-9-19(18)23-20(25)11-10-16-14-22-24(15-16)12-13-26-17-6-2-1-3-7-17/h1-11,14-15H,12-13,21H2,(H,23,25)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375727
PNG
(US10301323, Compound D9 | US9908899, Compound D9)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCCCc2ccccc2)c1
Show InChI InChI=1S/C22H24N4O/c23-20-11-4-5-12-21(20)25-22(27)14-13-19-16-24-26(17-19)15-7-6-10-18-8-2-1-3-9-18/h1-5,8-9,11-14,16-17H,6-7,10,15,23H2,(H,25,27)/b14-13+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375733
PNG
(US10301323, Compound B2 | US9908899, Compound B2)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(C\C=C\c2ccc(F)cc2)c1
Show InChI InChI=1S/C21H19FN4O/c22-18-10-7-16(8-11-18)4-3-13-26-15-17(14-24-26)9-12-21(27)25-20-6-2-1-5-19(20)23/h1-12,14-15H,13,23H2,(H,25,27)/b4-3+,12-9+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375733
PNG
(US10301323, Compound B2 | US9908899, Compound B2)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(C\C=C\c2ccc(F)cc2)c1
Show InChI InChI=1S/C21H19FN4O/c22-18-10-7-16(8-11-18)4-3-13-26-15-17(14-24-26)9-12-21(27)25-20-6-2-1-5-19(20)23/h1-12,14-15H,13,23H2,(H,25,27)/b4-3+,12-9+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375737
PNG
(US10301323, Compound B5 | US9908899, Compound B5)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2cc(F)cc(Cl)c2)c1
Show InChI InChI=1S/C20H18ClFN4O2/c21-15-9-16(22)11-17(10-15)28-8-7-26-13-14(12-24-26)5-6-20(27)25-19-4-2-1-3-18(19)23/h1-6,9-13H,7-8,23H2,(H,25,27)/b6-5+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375740
PNG
(US10301323, Compound D7 | US9908899, Compound D7)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCc2ccccc2)c1
Show InChI InChI=1S/C20H20N4O/c21-18-8-4-5-9-19(18)23-20(25)11-10-17-14-22-24(15-17)13-12-16-6-2-1-3-7-16/h1-11,14-15H,12-13,21H2,(H,23,25)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375741
PNG
(US10301323, Compound D8 | US9908899, Compound D8)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCCc2ccccc2)c1
Show InChI InChI=1S/C21H22N4O/c22-19-10-4-5-11-20(19)24-21(26)13-12-18-15-23-25(16-18)14-6-9-17-7-2-1-3-8-17/h1-5,7-8,10-13,15-16H,6,9,14,22H2,(H,24,26)/b13-12+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375741
PNG
(US10301323, Compound D8 | US9908899, Compound D8)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCCc2ccccc2)c1
Show InChI InChI=1S/C21H22N4O/c22-19-10-4-5-11-20(19)24-21(26)13-12-18-15-23-25(16-18)14-6-9-17-7-2-1-3-8-17/h1-5,7-8,10-13,15-16H,6,9,14,22H2,(H,24,26)/b13-12+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375742
PNG
(US10301323, Compound D14 | US9908899, Compound D14)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOCc2ccccc2)c1
Show InChI InChI=1S/C21H22N4O2/c22-19-8-4-5-9-20(19)24-21(26)11-10-18-14-23-25(15-18)12-13-27-16-17-6-2-1-3-7-17/h1-11,14-15H,12-13,16,22H2,(H,24,26)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375743
PNG
(US10301323, Compound D11 | US9908899, Compound D11)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CC\C=C\c2ccccc2)c1
Show InChI InChI=1S/C22H22N4O/c23-20-11-4-5-12-21(20)25-22(27)14-13-19-16-24-26(17-19)15-7-6-10-18-8-2-1-3-9-18/h1-6,8-14,16-17H,7,15,23H2,(H,25,27)/b10-6+,14-13+
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375746
PNG
(US10301323, Compound D13 | US9908899, Compound D13)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCc2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C22H21N5O/c23-19-6-2-4-8-21(19)26-22(28)10-9-16-13-25-27(15-16)12-11-17-14-24-20-7-3-1-5-18(17)20/h1-10,13-15,24H,11-12,23H2,(H,26,28)/b10-9+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM393045
PNG
(US10301323, Compound F10)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CN(CC3CC3)C2)c(Cl)c1
Show InChI InChI=1S/C21H22ClN3O/c22-18-10-17(21(26)24-20-4-2-1-3-19(20)23)8-7-16(18)9-15-12-25(13-15)11-14-5-6-14/h1-4,7-10,14H,5-6,11-13,23H2,(H,24,26)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375762
PNG
(US10301323, Compound A1 | US9908899, Compound A1)
Show SMILES Cc1nc(\C=C\C(=O)Nc2ccccc2N)cs1
Show InChI InChI=1S/C13H13N3OS/c1-9-15-10(8-18-9)6-7-13(17)16-12-5-3-2-4-11(12)14/h2-8H,14H2,1H3,(H,16,17)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375769
PNG
(US10301323, Compound F3 | US9908899, Compound F3)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CN(Cc3ccc4cc[nH]c4c3)C2)cc1
Show InChI InChI=1S/C26H24N4O/c27-23-3-1-2-4-24(23)29-26(31)22-9-5-18(6-10-22)13-20-16-30(17-20)15-19-7-8-21-11-12-28-25(21)14-19/h1-14,28H,15-17,27H2,(H,29,31)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375772
PNG
(US10301323, Compound F6 | US9908899, Compound F6)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CN(Cc3cccnc3)C2)c(Cl)c1
Show InChI InChI=1S/C23H21ClN4O/c24-20-11-19(23(29)27-22-6-2-1-5-21(22)25)8-7-18(20)10-17-14-28(15-17)13-16-4-3-9-26-12-16/h1-12H,13-15,25H2,(H,27,29)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375724
PNG
(US10301323, Compound D1 | US9908899, Compound D1)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(C\C=C\c2ccccc2)c1
Show InChI InChI=1S/C21H20N4O/c22-19-10-4-5-11-20(19)24-21(26)13-12-18-15-23-25(16-18)14-6-9-17-7-2-1-3-8-17/h1-13,15-16H,14,22H2,(H,24,26)/b9-6+,13-12+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375728
PNG
(US10301323, Compound B6 | US9908899, Compound B6)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2ccc(F)cc2)c1
Show InChI InChI=1S/C20H19FN4O2/c21-16-6-8-17(9-7-16)27-12-11-25-14-15(13-23-25)5-10-20(26)24-19-4-2-1-3-18(19)22/h1-10,13-14H,11-12,22H2,(H,24,26)/b10-5+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375735
PNG
(US10301323, Compound B3 | US9908899, Compound B3)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2cc(F)cc(F)c2)c1
Show InChI InChI=1S/C20H18F2N4O2/c21-15-9-16(22)11-17(10-15)28-8-7-26-13-14(12-24-26)5-6-20(27)25-19-4-2-1-3-18(19)23/h1-6,9-13H,7-8,23H2,(H,25,27)/b6-5+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375738
PNG
(US10301323, Compound A12 | US9908899, Compound A12)
Show SMILES Cn1cnc(\C=C\C(=O)Nc2ccccc2N)c1
Show InChI InChI=1S/C13H14N4O/c1-17-8-10(15-9-17)6-7-13(18)16-12-5-3-2-4-11(12)14/h2-9H,14H2,1H3,(H,16,18)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375742
PNG
(US10301323, Compound D14 | US9908899, Compound D14)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOCc2ccccc2)c1
Show InChI InChI=1S/C21H22N4O2/c22-19-8-4-5-9-20(19)24-21(26)11-10-18-14-23-25(15-18)12-13-27-16-17-6-2-1-3-7-17/h1-11,14-15H,12-13,16,22H2,(H,24,26)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375745
PNG
(US10301323, Compound D12 | US9908899, Compound D12)
Show SMILES CN(CCCn1cc(\C=C\C(=O)Nc2ccccc2N)cn1)c1ccccc1
Show InChI InChI=1S/C22H25N5O/c1-26(19-8-3-2-4-9-19)14-7-15-27-17-18(16-24-27)12-13-22(28)25-21-11-6-5-10-20(21)23/h2-6,8-13,16-17H,7,14-15,23H2,1H3,(H,25,28)/b13-12+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375753
PNG
(US10301323, Compound A10 | US9908899, Compound A10)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cn2ccnc2s1
Show InChI InChI=1S/C14H12N4OS/c15-11-3-1-2-4-12(11)17-13(19)6-5-10-9-18-8-7-16-14(18)20-10/h1-9H,15H2,(H,17,19)/b6-5+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375754
PNG
((E)-N-(2-aminophenyl)-3-(6-(ethoxymethyl)imidazo[2...)
Show SMILES CCOCc1cn2cc(\C=C\C(=O)Nc3ccccc3N)sc2n1
Show InChI InChI=1S/C17H18N4O2S/c1-2-23-11-12-9-21-10-13(24-17(21)19-12)7-8-16(22)20-15-6-4-3-5-14(15)18/h3-10H,2,11,18H2,1H3,(H,20,22)/b8-7+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM393047
PNG
(US10301323, Compound F12)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CN(CC3CC3)C2)cc1
Show InChI InChI=1S/C21H23N3O/c22-19-3-1-2-4-20(19)23-21(25)18-9-7-15(8-10-18)11-17-13-24(14-17)12-16-5-6-16/h1-4,7-11,16H,5-6,12-14,22H2,(H,23,25)
PDB

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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM393048
PNG
(US10301323, Compound F13)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CCN(CC3CC3)CC2)cc1
Show InChI InChI=1S/C23H27N3O/c24-21-3-1-2-4-22(21)25-23(27)20-9-7-17(8-10-20)15-18-11-13-26(14-12-18)16-19-5-6-19/h1-4,7-10,15,19H,5-6,11-14,16,24H2,(H,25,27)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM393048
PNG
(US10301323, Compound F13)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CCN(CC3CC3)CC2)cc1
Show InChI InChI=1S/C23H27N3O/c24-21-3-1-2-4-22(21)25-23(27)20-9-7-17(8-10-20)15-18-11-13-26(14-12-18)16-19-5-6-19/h1-4,7-10,15,19H,5-6,11-14,16,24H2,(H,25,27)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM393048
PNG
(US10301323, Compound F13)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CCN(CC3CC3)CC2)cc1
Show InChI InChI=1S/C23H27N3O/c24-21-3-1-2-4-22(21)25-23(27)20-9-7-17(8-10-20)15-18-11-13-26(14-12-18)16-19-5-6-19/h1-4,7-10,15,19H,5-6,11-14,16,24H2,(H,25,27)
PDB

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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM393049
PNG
(US10301323, Compound F14)
Show SMILES CC(C)(C)CN1CCC(CC1)=Cc1ccc(cc1)C(=O)Nc1ccccc1N
Show InChI InChI=1S/C24H31N3O/c1-24(2,3)17-27-14-12-19(13-15-27)16-18-8-10-20(11-9-18)23(28)26-22-7-5-4-6-21(22)25/h4-11,16H,12-15,17,25H2,1-3H3,(H,26,28)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM393051
PNG
(US10301323, Compound F16)
Show SMILES Cc1cccc(CN2CC(C2)=Cc2ccc(cc2)C(=O)Nc2ccccc2N)n1
Show InChI InChI=1S/C24H24N4O/c1-17-5-4-6-21(26-17)16-28-14-19(15-28)13-18-9-11-20(12-10-18)24(29)27-23-8-3-2-7-22(23)25/h2-13H,14-16,25H2,1H3,(H,27,29)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM393055
PNG
(US10301323, Compound F19)
Show SMILES CC(C)(O)CN1CC(C1)=Cc1ccc(cc1)C(=O)Nc1ccccc1N
Show InChI InChI=1S/C21H25N3O2/c1-21(2,26)14-24-12-16(13-24)11-15-7-9-17(10-8-15)20(25)23-19-6-4-3-5-18(19)22/h3-11,26H,12-14,22H2,1-2H3,(H,23,25)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375768
PNG
(US10301323, Compound F2 | US9908899, Compound F2)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CCN(Cc3cccnc3)CC2)cc1
Show InChI InChI=1S/C25H26N4O/c26-23-5-1-2-6-24(23)28-25(30)22-9-7-19(8-10-22)16-20-11-14-29(15-12-20)18-21-4-3-13-27-17-21/h1-10,13,16-17H,11-12,14-15,18,26H2,(H,28,30)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375769
PNG
(US10301323, Compound F3 | US9908899, Compound F3)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CN(Cc3ccc4cc[nH]c4c3)C2)cc1
Show InChI InChI=1S/C26H24N4O/c27-23-3-1-2-4-24(23)29-26(31)22-9-5-18(6-10-22)13-20-16-30(17-20)15-19-7-8-21-11-12-28-25(21)14-19/h1-14,28H,15-17,27H2,(H,29,31)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375770
PNG
(US10301323, Compound F4 | US9908899, Compound F4)
Show SMILES Nc1ccccc1NC(=O)c1ccc(CC2CN(Cc3ccc4cc[nH]c4c3)C2)cc1
Show InChI InChI=1S/C26H26N4O/c27-23-3-1-2-4-24(23)29-26(31)22-9-5-18(6-10-22)13-20-16-30(17-20)15-19-7-8-21-11-12-28-25(21)14-19/h1-12,14,20,28H,13,15-17,27H2,(H,29,31)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375772
PNG
(US10301323, Compound F6 | US9908899, Compound F6)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CN(Cc3cccnc3)C2)c(Cl)c1
Show InChI InChI=1S/C23H21ClN4O/c24-20-11-19(23(29)27-22-6-2-1-5-21(22)25)8-7-18(20)10-17-14-28(15-17)13-16-4-3-9-26-12-16/h1-12H,13-15,25H2,(H,27,29)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375773
PNG
(US10301323, Compound F7 | US9908899, Compound F7)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CCN(Cc3cccnc3)CC2)c(Cl)c1
Show InChI InChI=1S/C25H25ClN4O/c26-22-15-21(25(31)29-24-6-2-1-5-23(24)27)8-7-20(22)14-18-9-12-30(13-10-18)17-19-4-3-11-28-16-19/h1-8,11,14-16H,9-10,12-13,17,27H2,(H,29,31)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM50254780
PNG
(CHEMBL4078477 | US10301323, Compound D2 | US990889...)
Show SMILES Nc1cc(F)ccc1NC(=O)\C=C\c1cnn(C\C=C\c2ccccc2)c1
Show InChI InChI=1S/C21H19FN4O/c22-18-9-10-20(19(23)13-18)25-21(27)11-8-17-14-24-26(15-17)12-4-7-16-5-2-1-3-6-16/h1-11,13-15H,12,23H2,(H,25,27)/b7-4+,11-8+
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375735
PNG
(US10301323, Compound B3 | US9908899, Compound B3)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2cc(F)cc(F)c2)c1
Show InChI InChI=1S/C20H18F2N4O2/c21-15-9-16(22)11-17(10-15)28-8-7-26-13-14(12-24-26)5-6-20(27)25-19-4-2-1-3-18(19)23/h1-6,9-13H,7-8,23H2,(H,25,27)/b6-5+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375739
PNG
(US10301323, Compound D4 | US9908899, Compound D4)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(Cc2ccccc2)c1
Show InChI InChI=1S/C19H18N4O/c20-17-8-4-5-9-18(17)22-19(24)11-10-16-12-21-23(14-16)13-15-6-2-1-3-7-15/h1-12,14H,13,20H2,(H,22,24)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375741
PNG
(US10301323, Compound D8 | US9908899, Compound D8)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCCc2ccccc2)c1
Show InChI InChI=1S/C21H22N4O/c22-19-10-4-5-11-20(19)24-21(26)13-12-18-15-23-25(16-18)14-6-9-17-7-2-1-3-8-17/h1-5,7-8,10-13,15-16H,6,9,14,22H2,(H,24,26)/b13-12+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375746
PNG
(US10301323, Compound D13 | US9908899, Compound D13)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCc2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C22H21N5O/c23-19-6-2-4-8-21(19)26-22(28)10-9-16-13-25-27(15-16)12-11-17-14-24-20-7-3-1-5-18(17)20/h1-10,13-15,24H,11-12,23H2,(H,26,28)/b10-9+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375747
PNG
(US10301323, Compound D15 | US9908899, Compound D15)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCCOc2ccccc2)c1
Show InChI InChI=1S/C21H22N4O2/c22-19-9-4-5-10-20(19)24-21(26)12-11-17-15-23-25(16-17)13-6-14-27-18-7-2-1-3-8-18/h1-5,7-12,15-16H,6,13-14,22H2,(H,24,26)/b12-11+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375748
PNG
(US10301323, Compound D10 | US9908899, Compound D10)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CC(F)(F)c2ccccc2)c1
Show InChI InChI=1S/C20H18F2N4O/c21-20(22,16-6-2-1-3-7-16)14-26-13-15(12-24-26)10-11-19(27)25-18-9-5-4-8-17(18)23/h1-13H,14,23H2,(H,25,27)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375751
PNG
(US10301323, Compound A8 | US9908899, Compound A8)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cc2ccccn2n1
Show InChI InChI=1S/C16H14N4O/c17-14-6-1-2-7-15(14)18-16(21)9-8-12-11-13-5-3-4-10-20(13)19-12/h1-11H,17H2,(H,18,21)/b9-8+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM393047
PNG
(US10301323, Compound F12)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CN(CC3CC3)C2)cc1
Show InChI InChI=1S/C21H23N3O/c22-19-3-1-2-4-20(19)23-21(25)18-9-7-15(8-10-18)11-17-13-24(14-17)12-16-5-6-16/h1-4,7-11,16H,5-6,12-14,22H2,(H,23,25)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM393049
PNG
(US10301323, Compound F14)
Show SMILES CC(C)(C)CN1CCC(CC1)=Cc1ccc(cc1)C(=O)Nc1ccccc1N
Show InChI InChI=1S/C24H31N3O/c1-24(2,3)17-27-14-12-19(13-15-27)16-18-8-10-20(11-9-18)23(28)26-22-7-5-4-6-21(22)25/h4-11,16H,12-15,17,25H2,1-3H3,(H,26,28)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM393049
PNG
(US10301323, Compound F14)
Show SMILES CC(C)(C)CN1CCC(CC1)=Cc1ccc(cc1)C(=O)Nc1ccccc1N
Show InChI InChI=1S/C24H31N3O/c1-24(2,3)17-27-14-12-19(13-15-27)16-18-8-10-20(11-9-18)23(28)26-22-7-5-4-6-21(22)25/h4-11,16H,12-15,17,25H2,1-3H3,(H,26,28)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM393052
PNG
(US10301323, Compound F17)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CN(Cc3ccccc3)C2)cc1
Show InChI InChI=1S/C24H23N3O/c25-22-8-4-5-9-23(22)26-24(28)21-12-10-18(11-13-21)14-20-16-27(17-20)15-19-6-2-1-3-7-19/h1-14H,15-17,25H2,(H,26,28)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375763
PNG
(US10301323, Compound A3 | US9908899, Compound A3)
Show SMILES Cc1ncc(\C=C\C(=O)Nc2ccccc2N)s1
Show InChI InChI=1S/C13H13N3OS/c1-9-15-8-10(18-9)6-7-13(17)16-12-5-3-2-4-11(12)14/h2-8H,14H2,1H3,(H,16,17)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375768
PNG
(US10301323, Compound F2 | US9908899, Compound F2)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CCN(Cc3cccnc3)CC2)cc1
Show InChI InChI=1S/C25H26N4O/c26-23-5-1-2-6-24(23)28-25(30)22-9-7-19(8-10-22)16-20-11-14-29(15-12-20)18-21-4-3-13-27-17-21/h1-10,13,16-17H,11-12,14-15,18,26H2,(H,28,30)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375768
PNG
(US10301323, Compound F2 | US9908899, Compound F2)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CCN(Cc3cccnc3)CC2)cc1
Show InChI InChI=1S/C25H26N4O/c26-23-5-1-2-6-24(23)28-25(30)22-9-7-19(8-10-22)16-20-11-14-29(15-12-20)18-21-4-3-13-27-17-21/h1-10,13,16-17H,11-12,14-15,18,26H2,(H,28,30)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375770
PNG
(US10301323, Compound F4 | US9908899, Compound F4)
Show SMILES Nc1ccccc1NC(=O)c1ccc(CC2CN(Cc3ccc4cc[nH]c4c3)C2)cc1
Show InChI InChI=1S/C26H26N4O/c27-23-3-1-2-4-24(23)29-26(31)22-9-5-18(6-10-22)13-20-16-30(17-20)15-19-7-8-21-11-12-28-25(21)14-19/h1-12,14,20,28H,13,15-17,27H2,(H,29,31)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375773
PNG
(US10301323, Compound F7 | US9908899, Compound F7)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CCN(Cc3cccnc3)CC2)c(Cl)c1
Show InChI InChI=1S/C25H25ClN4O/c26-22-15-21(25(31)29-24-6-2-1-5-23(24)27)8-7-20(22)14-18-9-12-30(13-10-18)17-19-4-3-11-28-16-19/h1-8,11,14-16H,9-10,12-13,17,27H2,(H,29,31)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375775
PNG
(US10301323, Compound G2 | US9908899, Compound G2)
Show SMILES Cc1nn(C\C=C\c2ccccc2)c(C)c1\C=C\C(=O)Nc1ccccc1N
Show InChI InChI=1S/C23H24N4O/c1-17-20(14-15-23(28)25-22-13-7-6-12-21(22)24)18(2)27(26-17)16-8-11-19-9-4-3-5-10-19/h3-15H,16,24H2,1-2H3,(H,25,28)/b11-8+,15-14+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375773
PNG
(US10301323, Compound F7 | US9908899, Compound F7)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CCN(Cc3cccnc3)CC2)c(Cl)c1
Show InChI InChI=1S/C25H25ClN4O/c26-22-15-21(25(31)29-24-6-2-1-5-23(24)27)8-7-20(22)14-18-9-12-30(13-10-18)17-19-4-3-11-28-16-19/h1-8,11,14-16H,9-10,12-13,17,27H2,(H,29,31)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375726
PNG
(US10301323, Compound D3 | US9908899, Compound D3)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2ccccc2)c1
Show InChI InChI=1S/C20H20N4O2/c21-18-8-4-5-9-19(18)23-20(25)11-10-16-14-22-24(15-16)12-13-26-17-6-2-1-3-7-17/h1-11,14-15H,12-13,21H2,(H,23,25)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375726
PNG
(US10301323, Compound D3 | US9908899, Compound D3)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2ccccc2)c1
Show InChI InChI=1S/C20H20N4O2/c21-18-8-4-5-9-19(18)23-20(25)11-10-16-14-22-24(15-16)12-13-26-17-6-2-1-3-7-17/h1-11,14-15H,12-13,21H2,(H,23,25)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375727
PNG
(US10301323, Compound D9 | US9908899, Compound D9)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCCCc2ccccc2)c1
Show InChI InChI=1S/C22H24N4O/c23-20-11-4-5-12-21(20)25-22(27)14-13-19-16-24-26(17-19)15-7-6-10-18-8-2-1-3-9-18/h1-5,8-9,11-14,16-17H,6-7,10,15,23H2,(H,25,27)/b14-13+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375745
PNG
(US10301323, Compound D12 | US9908899, Compound D12)
Show SMILES CN(CCCn1cc(\C=C\C(=O)Nc2ccccc2N)cn1)c1ccccc1
Show InChI InChI=1S/C22H25N5O/c1-26(19-8-3-2-4-9-19)14-7-15-27-17-18(16-24-27)12-13-22(28)25-21-11-6-5-10-20(21)23/h2-6,8-13,16-17H,7,14-15,23H2,1H3,(H,25,28)/b13-12+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375746
PNG
(US10301323, Compound D13 | US9908899, Compound D13)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCc2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C22H21N5O/c23-19-6-2-4-8-21(19)26-22(28)10-9-16-13-25-27(15-16)12-11-17-14-24-20-7-3-1-5-18(17)20/h1-10,13-15,24H,11-12,23H2,(H,26,28)/b10-9+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375749
PNG
(US10301323, Compound D6 | US9908899, Compound D6)
Show SMILES Cc1cccc(Cn2cc(\C=C\C(=O)Nc3ccccc3N)cn2)n1
Show InChI InChI=1S/C19H19N5O/c1-14-5-4-6-16(22-14)13-24-12-15(11-21-24)9-10-19(25)23-18-8-3-2-7-17(18)20/h2-12H,13,20H2,1H3,(H,23,25)/b10-9+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM393043
PNG
(US10301323, Compound F8)
Show SMILES CN1C2CCC1CC(C2)=Cc1ccc(cc1Cl)C(=O)Nc1ccccc1N
Show InChI InChI=1S/C22H24ClN3O/c1-26-17-8-9-18(26)12-14(11-17)10-15-6-7-16(13-19(15)23)22(27)25-21-5-3-2-4-20(21)24/h2-7,10,13,17-18H,8-9,11-12,24H2,1H3,(H,25,27)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM393044
PNG
(US10301323, Compound F9)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2COC2)cc1F
Show InChI InChI=1S/C17H15FN2O2/c18-14-8-11(7-12-9-22-10-12)5-6-13(14)17(21)20-16-4-2-1-3-15(16)19/h1-8H,9-10,19H2,(H,20,21)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM393045
PNG
(US10301323, Compound F10)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CN(CC3CC3)C2)c(Cl)c1
Show InChI InChI=1S/C21H22ClN3O/c22-18-10-17(21(26)24-20-4-2-1-3-19(20)23)8-7-16(18)9-15-12-25(13-15)11-14-5-6-14/h1-4,7-10,14H,5-6,11-13,23H2,(H,24,26)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM393050
PNG
(US10301323, Compound F15)
Show SMILES CC(C)(O)CN1CCC(CC1)=Cc1ccc(cc1)C(=O)Nc1ccccc1N
Show InChI InChI=1S/C23H29N3O2/c1-23(2,28)16-26-13-11-18(12-14-26)15-17-7-9-19(10-8-17)22(27)25-21-6-4-3-5-20(21)24/h3-10,15,28H,11-14,16,24H2,1-2H3,(H,25,27)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM393051
PNG
(US10301323, Compound F16)
Show SMILES Cc1cccc(CN2CC(C2)=Cc2ccc(cc2)C(=O)Nc2ccccc2N)n1
Show InChI InChI=1S/C24H24N4O/c1-17-5-4-6-21(26-17)16-28-14-19(15-28)13-18-9-11-20(12-10-18)24(29)27-23-8-3-2-7-22(23)25/h2-13H,14-16,25H2,1H3,(H,27,29)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM393052
PNG
(US10301323, Compound F17)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CN(Cc3ccccc3)C2)cc1
Show InChI InChI=1S/C24H23N3O/c25-22-8-4-5-9-23(22)26-24(28)21-12-10-18(11-13-21)14-20-16-27(17-20)15-19-6-2-1-3-7-19/h1-14H,15-17,25H2,(H,26,28)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375760
PNG
(US10301323, Compound C1 | US9908899, Compound C1)
Show SMILES CCn1cc(\C=C\C(=O)Nc2ccccc2N)cn1
Show InChI InChI=1S/C14H16N4O/c1-2-18-10-11(9-16-18)7-8-14(19)17-13-6-4-3-5-12(13)15/h3-10H,2,15H2,1H3,(H,17,19)/b8-7+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375771
PNG
(US10301323, Compound F5 | US9908899, Compound F5)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CN(Cc3ccc4cc[nH]c4c3)C2)c(Cl)c1
Show InChI InChI=1S/C26H23ClN4O/c27-22-13-21(26(32)30-24-4-2-1-3-23(24)28)8-7-20(22)11-18-15-31(16-18)14-17-5-6-19-9-10-29-25(19)12-17/h1-13,29H,14-16,28H2,(H,30,32)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375774
PNG
(US10301323, Compound G1 | US9908899, Compound G1)
Show SMILES CN1CCC(Cn2cc(\C=C\C(=O)Nc3ccccc3N)cn2)CC1
Show InChI InChI=1S/C19H25N5O/c1-23-10-8-15(9-11-23)13-24-14-16(12-21-24)6-7-19(25)22-18-5-3-2-4-17(18)20/h2-7,12,14-15H,8-11,13,20H2,1H3,(H,22,25)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375773
PNG
(US10301323, Compound F7 | US9908899, Compound F7)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CCN(Cc3cccnc3)CC2)c(Cl)c1
Show InChI InChI=1S/C25H25ClN4O/c26-22-15-21(25(31)29-24-6-2-1-5-23(24)27)8-7-20(22)14-18-9-12-30(13-10-18)17-19-4-3-11-28-16-19/h1-8,11,14-16H,9-10,12-13,17,27H2,(H,29,31)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375727
PNG
(US10301323, Compound D9 | US9908899, Compound D9)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCCCc2ccccc2)c1
Show InChI InChI=1S/C22H24N4O/c23-20-11-4-5-12-21(20)25-22(27)14-13-19-16-24-26(17-19)15-7-6-10-18-8-2-1-3-9-18/h1-5,8-9,11-14,16-17H,6-7,10,15,23H2,(H,25,27)/b14-13+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375736
PNG
(US10301323, Compound D16 | US9908899, Compound D16)
Show SMILES Nc1cc(F)ccc1NC(=O)\C=C\c1cnn(CCOc2ccccc2)c1
Show InChI InChI=1S/C20H19FN4O2/c21-16-7-8-19(18(22)12-16)24-20(26)9-6-15-13-23-25(14-15)10-11-27-17-4-2-1-3-5-17/h1-9,12-14H,10-11,22H2,(H,24,26)/b9-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375737
PNG
(US10301323, Compound B5 | US9908899, Compound B5)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2cc(F)cc(Cl)c2)c1
Show InChI InChI=1S/C20H18ClFN4O2/c21-15-9-16(22)11-17(10-15)28-8-7-26-13-14(12-24-26)5-6-20(27)25-19-4-2-1-3-18(19)23/h1-6,9-13H,7-8,23H2,(H,25,27)/b6-5+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375747
PNG
(US10301323, Compound D15 | US9908899, Compound D15)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCCOc2ccccc2)c1
Show InChI InChI=1S/C21H22N4O2/c22-19-9-4-5-10-20(19)24-21(26)12-11-17-15-23-25(16-17)13-6-14-27-18-7-2-1-3-8-18/h1-5,7-12,15-16H,6,13-14,22H2,(H,24,26)/b12-11+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375748
PNG
(US10301323, Compound D10 | US9908899, Compound D10)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CC(F)(F)c2ccccc2)c1
Show InChI InChI=1S/C20H18F2N4O/c21-20(22,16-6-2-1-3-7-16)14-26-13-15(12-24-26)10-11-19(27)25-18-9-5-4-8-17(18)23/h1-13H,14,23H2,(H,25,27)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375752
PNG
(US10301323, Compound A9 | US9908899, Compound A9)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cn2ccccc2n1
Show InChI InChI=1S/C16H14N4O/c17-13-5-1-2-6-14(13)19-16(21)9-8-12-11-20-10-4-3-7-15(20)18-12/h1-11H,17H2,(H,19,21)/b9-8+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM393044
PNG
(US10301323, Compound F9)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2COC2)cc1F
Show InChI InChI=1S/C17H15FN2O2/c18-14-8-11(7-12-9-22-10-12)5-6-13(14)17(21)20-16-4-2-1-3-15(16)19/h1-8H,9-10,19H2,(H,20,21)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM393046
PNG
(US10301323, Compound F11)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2COC2)c(Cl)c1
Show InChI InChI=1S/C17H15ClN2O2/c18-14-8-13(6-5-12(14)7-11-9-22-10-11)17(21)20-16-4-2-1-3-15(16)19/h1-8H,9-10,19H2,(H,20,21)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM393047
PNG
(US10301323, Compound F12)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CN(CC3CC3)C2)cc1
Show InChI InChI=1S/C21H23N3O/c22-19-3-1-2-4-20(19)23-21(25)18-9-7-15(8-10-18)11-17-13-24(14-17)12-16-5-6-16/h1-4,7-11,16H,5-6,12-14,22H2,(H,23,25)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM393051
PNG
(US10301323, Compound F16)
Show SMILES Cc1cccc(CN2CC(C2)=Cc2ccc(cc2)C(=O)Nc2ccccc2N)n1
Show InChI InChI=1S/C24H24N4O/c1-17-5-4-6-21(26-17)16-28-14-19(15-28)13-18-9-11-20(12-10-18)24(29)27-23-8-3-2-7-22(23)25/h2-13H,14-16,25H2,1H3,(H,27,29)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM393054
PNG
(US10301323, Compound F18)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CN(Cc3cccnc3)C2)cc1
Show InChI InChI=1S/C23H22N4O/c24-21-5-1-2-6-22(21)26-23(28)20-9-7-17(8-10-20)12-19-15-27(16-19)14-18-4-3-11-25-13-18/h1-13H,14-16,24H2,(H,26,28)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM393055
PNG
(US10301323, Compound F19)
Show SMILES CC(C)(O)CN1CC(C1)=Cc1ccc(cc1)C(=O)Nc1ccccc1N
Show InChI InChI=1S/C21H25N3O2/c1-21(2,26)14-24-12-16(13-24)11-15-7-9-17(10-8-15)20(25)23-19-6-4-3-5-18(19)22/h3-11,26H,12-14,22H2,1-2H3,(H,23,25)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375756
PNG
(US10301323, Compound A7 | US9908899, Compound A7)
Show SMILES Cn1ccc(\C=C\C(=O)Nc2ccccc2N)n1
Show InChI InChI=1S/C13H14N4O/c1-17-9-8-10(16-17)6-7-13(18)15-12-5-3-2-4-11(12)14/h2-9H,14H2,1H3,(H,15,18)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375761
PNG
(US10301323, Compound B1 | US9908899, Compound B1)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CC2CC2)c1
Show InChI InChI=1S/C16H18N4O/c17-14-3-1-2-4-15(14)19-16(21)8-7-13-9-18-20(11-13)10-12-5-6-12/h1-4,7-9,11-12H,5-6,10,17H2,(H,19,21)/b8-7+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375773
PNG
(US10301323, Compound F7 | US9908899, Compound F7)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CCN(Cc3cccnc3)CC2)c(Cl)c1
Show InChI InChI=1S/C25H25ClN4O/c26-22-15-21(25(31)29-24-6-2-1-5-23(24)27)8-7-20(22)14-18-9-12-30(13-10-18)17-19-4-3-11-28-16-19/h1-8,11,14-16H,9-10,12-13,17,27H2,(H,29,31)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM393043
PNG
(US10301323, Compound F8)
Show SMILES CN1C2CCC1CC(C2)=Cc1ccc(cc1Cl)C(=O)Nc1ccccc1N
Show InChI InChI=1S/C22H24ClN3O/c1-26-17-8-9-18(26)12-14(11-17)10-15-6-7-16(13-19(15)23)22(27)25-21-5-3-2-4-20(21)24/h2-7,10,13,17-18H,8-9,11-12,24H2,1H3,(H,25,27)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM50254780
PNG
(CHEMBL4078477 | US10301323, Compound D2 | US990889...)
Show SMILES Nc1cc(F)ccc1NC(=O)\C=C\c1cnn(C\C=C\c2ccccc2)c1
Show InChI InChI=1S/C21H19FN4O/c22-18-9-10-20(19(23)13-18)25-21(27)11-8-17-14-24-26(15-17)12-4-7-16-5-2-1-3-6-16/h1-11,13-15H,12,23H2,(H,25,27)/b7-4+,11-8+
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n/an/a 3.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375766
PNG
((E)-N-(2-aminophenyl)-3-(2-cinnamylthiazol-4-yl)ac...)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1csc(C\C=C\c2ccccc2)n1
Show InChI InChI=1S/C21H19N3OS/c22-18-10-4-5-11-19(18)24-20(25)14-13-17-15-26-21(23-17)12-6-9-16-7-2-1-3-8-16/h1-11,13-15H,12,22H2,(H,24,25)/b9-6+,14-13+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375762
PNG
(US10301323, Compound A1 | US9908899, Compound A1)
Show SMILES Cc1nc(\C=C\C(=O)Nc2ccccc2N)cs1
Show InChI InChI=1S/C13H13N3OS/c1-9-15-10(8-18-9)6-7-13(17)16-12-5-3-2-4-11(12)14/h2-8H,14H2,1H3,(H,16,17)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375751
PNG
(US10301323, Compound A8 | US9908899, Compound A8)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cc2ccccn2n1
Show InChI InChI=1S/C16H14N4O/c17-14-6-1-2-7-15(14)18-16(21)9-8-12-11-13-5-3-4-10-20(13)19-12/h1-11H,17H2,(H,18,21)/b9-8+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375758
PNG
(US10301323, Compound C3 | US9908899, Compound C3)
Show SMILES Cn1cc(\C=C\C(=O)Nc2cc(F)ccc2N)cn1
Show InChI InChI=1S/C13H13FN4O/c1-18-8-9(7-16-18)2-5-13(19)17-12-6-10(14)3-4-11(12)15/h2-8H,15H2,1H3,(H,17,19)/b5-2+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM393046
PNG
(US10301323, Compound F11)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2COC2)c(Cl)c1
Show InChI InChI=1S/C17H15ClN2O2/c18-14-8-13(6-5-12(14)7-11-9-22-10-11)17(21)20-16-4-2-1-3-15(16)19/h1-8H,9-10,19H2,(H,20,21)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375753
PNG
(US10301323, Compound A10 | US9908899, Compound A10)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cn2ccnc2s1
Show InChI InChI=1S/C14H12N4OS/c15-11-3-1-2-4-12(11)17-13(19)6-5-10-9-18-8-7-16-14(18)20-10/h1-9H,15H2,(H,17,19)/b6-5+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375752
PNG
(US10301323, Compound A9 | US9908899, Compound A9)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cn2ccccc2n1
Show InChI InChI=1S/C16H14N4O/c17-13-5-1-2-6-14(13)19-16(21)9-8-12-11-20-10-4-3-7-15(20)18-12/h1-11H,17H2,(H,19,21)/b9-8+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375739
PNG
(US10301323, Compound D4 | US9908899, Compound D4)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(Cc2ccccc2)c1
Show InChI InChI=1S/C19H18N4O/c20-17-8-4-5-9-18(17)22-19(24)11-10-16-12-21-23(14-16)13-15-6-2-1-3-7-15/h1-12,14H,13,20H2,(H,22,24)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375772
PNG
(US10301323, Compound F6 | US9908899, Compound F6)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CN(Cc3cccnc3)C2)c(Cl)c1
Show InChI InChI=1S/C23H21ClN4O/c24-20-11-19(23(29)27-22-6-2-1-5-21(22)25)8-7-18(20)10-17-14-28(15-17)13-16-4-3-9-26-12-16/h1-12H,13-15,25H2,(H,27,29)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375767
PNG
(US10301323, Compound F1 | US9908899, Compound F1)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CCN(CC2)C(=O)OCc2ccccc2)cc1
Show InChI InChI=1S/C27H27N3O3/c28-24-8-4-5-9-25(24)29-26(31)23-12-10-20(11-13-23)18-21-14-16-30(17-15-21)27(32)33-19-22-6-2-1-3-7-22/h1-13,18H,14-17,19,28H2,(H,29,31)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375756
PNG
(US10301323, Compound A7 | US9908899, Compound A7)
Show SMILES Cn1ccc(\C=C\C(=O)Nc2ccccc2N)n1
Show InChI InChI=1S/C13H14N4O/c1-17-9-8-10(16-17)6-7-13(18)15-12-5-3-2-4-11(12)14/h2-9H,14H2,1H3,(H,15,18)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375752
PNG
(US10301323, Compound A9 | US9908899, Compound A9)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cn2ccccc2n1
Show InChI InChI=1S/C16H14N4O/c17-13-5-1-2-6-14(13)19-16(21)9-8-12-11-20-10-4-3-7-15(20)18-12/h1-11H,17H2,(H,19,21)/b9-8+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375748
PNG
(US10301323, Compound D10 | US9908899, Compound D10)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CC(F)(F)c2ccccc2)c1
Show InChI InChI=1S/C20H18F2N4O/c21-20(22,16-6-2-1-3-7-16)14-26-13-15(12-24-26)10-11-19(27)25-18-9-5-4-8-17(18)23/h1-13H,14,23H2,(H,25,27)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375733
PNG
(US10301323, Compound B2 | US9908899, Compound B2)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(C\C=C\c2ccc(F)cc2)c1
Show InChI InChI=1S/C21H19FN4O/c22-18-10-7-16(8-11-18)4-3-13-26-15-17(14-24-26)9-12-21(27)25-20-6-2-1-5-19(20)23/h1-12,14-15H,13,23H2,(H,25,27)/b4-3+,12-9+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50254780
PNG
(CHEMBL4078477 | US10301323, Compound D2 | US990889...)
Show SMILES Nc1cc(F)ccc1NC(=O)\C=C\c1cnn(C\C=C\c2ccccc2)c1
Show InChI InChI=1S/C21H19FN4O/c22-18-9-10-20(19(23)13-18)25-21(27)11-8-17-14-24-26(15-17)12-4-7-16-5-2-1-3-6-16/h1-11,13-15H,12,23H2,(H,25,27)/b7-4+,11-8+
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n/an/a 3.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375775
PNG
(US10301323, Compound G2 | US9908899, Compound G2)
Show SMILES Cc1nn(C\C=C\c2ccccc2)c(C)c1\C=C\C(=O)Nc1ccccc1N
Show InChI InChI=1S/C23H24N4O/c1-17-20(14-15-23(28)25-22-13-7-6-12-21(22)24)18(2)27(26-17)16-8-11-19-9-4-3-5-10-19/h3-15H,16,24H2,1-2H3,(H,25,28)/b11-8+,15-14+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375774
PNG
(US10301323, Compound G1 | US9908899, Compound G1)
Show SMILES CN1CCC(Cn2cc(\C=C\C(=O)Nc3ccccc3N)cn2)CC1
Show InChI InChI=1S/C19H25N5O/c1-23-10-8-15(9-11-23)13-24-14-16(12-21-24)6-7-19(25)22-18-5-3-2-4-17(18)20/h2-7,12,14-15H,8-11,13,20H2,1H3,(H,22,25)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375764
PNG
(US10301323, Compound A4 | US9908899, Compound A4)
Show SMILES Cc1nc(\C=C\C(=O)Nc2ccccc2N)co1
Show InChI InChI=1S/C13H13N3O2/c1-9-15-10(8-18-9)6-7-13(17)16-12-5-3-2-4-11(12)14/h2-8H,14H2,1H3,(H,16,17)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375736
PNG
(US10301323, Compound D16 | US9908899, Compound D16)
Show SMILES Nc1cc(F)ccc1NC(=O)\C=C\c1cnn(CCOc2ccccc2)c1
Show InChI InChI=1S/C20H19FN4O2/c21-16-7-8-19(18(22)12-16)24-20(26)9-6-15-13-23-25(14-15)10-11-27-17-4-2-1-3-5-17/h1-9,12-14H,10-11,22H2,(H,24,26)/b9-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375738
PNG
(US10301323, Compound A12 | US9908899, Compound A12)
Show SMILES Cn1cnc(\C=C\C(=O)Nc2ccccc2N)c1
Show InChI InChI=1S/C13H14N4O/c1-17-8-10(15-9-17)6-7-13(18)16-12-5-3-2-4-11(12)14/h2-9H,14H2,1H3,(H,16,18)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375749
PNG
(US10301323, Compound D6 | US9908899, Compound D6)
Show SMILES Cc1cccc(Cn2cc(\C=C\C(=O)Nc3ccccc3N)cn2)n1
Show InChI InChI=1S/C19H19N5O/c1-14-5-4-6-16(22-14)13-24-12-15(11-21-24)9-10-19(25)23-18-8-3-2-7-17(18)20/h2-12H,13,20H2,1H3,(H,23,25)/b10-9+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375749
PNG
(US10301323, Compound D6 | US9908899, Compound D6)
Show SMILES Cc1cccc(Cn2cc(\C=C\C(=O)Nc3ccccc3N)cn2)n1
Show InChI InChI=1S/C19H19N5O/c1-14-5-4-6-16(22-14)13-24-12-15(11-21-24)9-10-19(25)23-18-8-3-2-7-17(18)20/h2-12H,13,20H2,1H3,(H,23,25)/b10-9+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375753
PNG
(US10301323, Compound A10 | US9908899, Compound A10)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cn2ccnc2s1
Show InChI InChI=1S/C14H12N4OS/c15-11-3-1-2-4-12(11)17-13(19)6-5-10-9-18-8-7-16-14(18)20-10/h1-9H,15H2,(H,17,19)/b6-5+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM393056
PNG
(US10301323, Compound F20)
Show SMILES Nc1cc(F)ccc1NC(=O)c1ccc(C=C2CN(CC3CC3)C2)cc1
Show InChI InChI=1S/C21H22FN3O/c22-18-7-8-20(19(23)10-18)24-21(26)17-5-3-14(4-6-17)9-16-12-25(13-16)11-15-1-2-15/h3-10,15H,1-2,11-13,23H2,(H,24,26)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375759
PNG
(US10301323, Compound A11 | US9908899, Compound A11)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(c1)-c1ccccc1
Show InChI InChI=1S/C18H16N4O/c19-16-8-4-5-9-17(16)21-18(23)11-10-14-12-20-22(13-14)15-6-2-1-3-7-15/h1-13H,19H2,(H,21,23)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375774
PNG
(US10301323, Compound G1 | US9908899, Compound G1)
Show SMILES CN1CCC(Cn2cc(\C=C\C(=O)Nc3ccccc3N)cn2)CC1
Show InChI InChI=1S/C19H25N5O/c1-23-10-8-15(9-11-23)13-24-14-16(12-21-24)6-7-19(25)22-18-5-3-2-4-17(18)20/h2-7,12,14-15H,8-11,13,20H2,1H3,(H,22,25)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375775
PNG
(US10301323, Compound G2 | US9908899, Compound G2)
Show SMILES Cc1nn(C\C=C\c2ccccc2)c(C)c1\C=C\C(=O)Nc1ccccc1N
Show InChI InChI=1S/C23H24N4O/c1-17-20(14-15-23(28)25-22-13-7-6-12-21(22)24)18(2)27(26-17)16-8-11-19-9-4-3-5-10-19/h3-15H,16,24H2,1-2H3,(H,25,28)/b11-8+,15-14+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM393055
PNG
(US10301323, Compound F19)
Show SMILES CC(C)(O)CN1CC(C1)=Cc1ccc(cc1)C(=O)Nc1ccccc1N
Show InChI InChI=1S/C21H25N3O2/c1-21(2,26)14-24-12-16(13-24)11-15-7-9-17(10-8-15)20(25)23-19-6-4-3-5-18(19)22/h3-11,26H,12-14,22H2,1-2H3,(H,23,25)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375744
PNG
(US10301323, Compound D5 | US9908899, Compound D5)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(Cc2ccc(F)cc2)c1
Show InChI InChI=1S/C19H17FN4O/c20-16-8-5-14(6-9-16)12-24-13-15(11-22-24)7-10-19(25)23-18-4-2-1-3-17(18)21/h1-11,13H,12,21H2,(H,23,25)/b10-7+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375754
PNG
((E)-N-(2-aminophenyl)-3-(6-(ethoxymethyl)imidazo[2...)
Show SMILES CCOCc1cn2cc(\C=C\C(=O)Nc3ccccc3N)sc2n1
Show InChI InChI=1S/C17H18N4O2S/c1-2-23-11-12-9-21-10-13(24-17(21)19-12)7-8-16(22)20-15-6-4-3-5-14(15)18/h3-10H,2,11,18H2,1H3,(H,20,22)/b8-7+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375756
PNG
(US10301323, Compound A7 | US9908899, Compound A7)
Show SMILES Cn1ccc(\C=C\C(=O)Nc2ccccc2N)n1
Show InChI InChI=1S/C13H14N4O/c1-17-9-8-10(16-17)6-7-13(18)15-12-5-3-2-4-11(12)14/h2-9H,14H2,1H3,(H,15,18)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM375757
PNG
(US10301323, Compound C2 | US9908899, Compound C2)
Show SMILES Cn1cc(\C=C\C(=O)Nc2ccc(F)cc2N)cn1
Show InChI InChI=1S/C13H13FN4O/c1-18-8-9(7-16-18)2-5-13(19)17-12-4-3-10(14)6-11(12)15/h2-8H,15H2,1H3,(H,17,19)/b5-2+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375759
PNG
(US10301323, Compound A11 | US9908899, Compound A11)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(c1)-c1ccccc1
Show InChI InChI=1S/C18H16N4O/c19-16-8-4-5-9-17(16)21-18(23)11-10-14-12-20-22(13-14)15-6-2-1-3-7-15/h1-13H,19H2,(H,21,23)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375760
PNG
(US10301323, Compound C1 | US9908899, Compound C1)
Show SMILES CCn1cc(\C=C\C(=O)Nc2ccccc2N)cn1
Show InChI InChI=1S/C14H16N4O/c1-2-18-10-11(9-16-18)7-8-14(19)17-13-6-4-3-5-12(13)15/h3-10H,2,15H2,1H3,(H,17,19)/b8-7+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375761
PNG
(US10301323, Compound B1 | US9908899, Compound B1)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CC2CC2)c1
Show InChI InChI=1S/C16H18N4O/c17-14-3-1-2-4-15(14)19-16(21)8-7-13-9-18-20(11-13)10-12-5-6-12/h1-4,7-9,11-12H,5-6,10,17H2,(H,19,21)/b8-7+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375734
PNG
(US10301323, Compound B4 | US9908899, Compound B4)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCOc2ccc(cc2)C(F)(F)F)c1
Show InChI InChI=1S/C21H19F3N4O2/c22-21(23,24)16-6-8-17(9-7-16)30-12-11-28-14-15(13-26-28)5-10-20(29)27-19-4-2-1-3-18(19)25/h1-10,13-14H,11-12,25H2,(H,27,29)/b10-5+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375740
PNG
(US10301323, Compound D7 | US9908899, Compound D7)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CCc2ccccc2)c1
Show InChI InChI=1S/C20H20N4O/c21-18-8-4-5-9-19(18)23-20(25)11-10-17-14-22-24(15-17)13-12-16-6-2-1-3-7-16/h1-11,14-15H,12-13,21H2,(H,23,25)/b11-10+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375758
PNG
(US10301323, Compound C3 | US9908899, Compound C3)
Show SMILES Cn1cc(\C=C\C(=O)Nc2cc(F)ccc2N)cn1
Show InChI InChI=1S/C13H13FN4O/c1-18-8-9(7-16-18)2-5-13(19)17-12-6-10(14)3-4-11(12)15/h2-8H,15H2,1H3,(H,17,19)/b5-2+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375771
PNG
(US10301323, Compound F5 | US9908899, Compound F5)
Show SMILES Nc1ccccc1NC(=O)c1ccc(C=C2CN(Cc3ccc4cc[nH]c4c3)C2)c(Cl)c1
Show InChI InChI=1S/C26H23ClN4O/c27-22-13-21(26(32)30-24-4-2-1-3-23(24)28)8-7-20(22)11-18-15-31(16-18)14-17-5-6-19-9-10-29-25(19)12-17/h1-13,29H,14-16,28H2,(H,30,32)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375736
PNG
(US10301323, Compound D16 | US9908899, Compound D16)
Show SMILES Nc1cc(F)ccc1NC(=O)\C=C\c1cnn(CCOc2ccccc2)c1
Show InChI InChI=1S/C20H19FN4O2/c21-16-7-8-19(18(22)12-16)24-20(26)9-6-15-13-23-25(14-15)10-11-27-17-4-2-1-3-5-17/h1-9,12-14H,10-11,22H2,(H,24,26)/b9-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM393056
PNG
(US10301323, Compound F20)
Show SMILES Nc1cc(F)ccc1NC(=O)c1ccc(C=C2CN(CC3CC3)C2)cc1
Show InChI InChI=1S/C21H22FN3O/c22-18-7-8-20(19(23)10-18)24-21(26)17-5-3-14(4-6-17)9-16-12-25(13-16)11-15-1-2-15/h3-10,15H,1-2,11-13,23H2,(H,24,26)
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375760
PNG
(US10301323, Compound C1 | US9908899, Compound C1)
Show SMILES CCn1cc(\C=C\C(=O)Nc2ccccc2N)cn1
Show InChI InChI=1S/C14H16N4O/c1-2-18-10-11(9-16-18)7-8-14(19)17-13-6-4-3-5-12(13)15/h3-10H,2,15H2,1H3,(H,17,19)/b8-7+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375750
PNG
(US10301323, Compound A6 | US9908899, Compound A6)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnc2ccccn12
Show InChI InChI=1S/C16H14N4O/c17-13-5-1-2-6-14(13)19-16(21)9-8-12-11-18-15-7-3-4-10-20(12)15/h1-11H,17H2,(H,19,21)/b9-8+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375755
PNG
(US10301323, Compound A2 | US9908899, Compound A2)
Show SMILES Cn1cc(\C=C\C(=O)Nc2ccccc2N)cn1
Show InChI InChI=1S/C13H14N4O/c1-17-9-10(8-15-17)6-7-13(18)16-12-5-3-2-4-11(12)14/h2-9H,14H2,1H3,(H,16,18)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375750
PNG
(US10301323, Compound A6 | US9908899, Compound A6)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnc2ccccn12
Show InChI InChI=1S/C16H14N4O/c17-13-5-1-2-6-14(13)19-16(21)9-8-12-11-18-15-7-3-4-10-20(12)15/h1-11H,17H2,(H,19,21)/b9-8+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375761
PNG
(US10301323, Compound B1 | US9908899, Compound B1)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1cnn(CC2CC2)c1
Show InChI InChI=1S/C16H18N4O/c17-14-3-1-2-4-15(14)19-16(21)8-7-13-9-18-20(11-13)10-12-5-6-12/h1-4,7-9,11-12H,5-6,10,17H2,(H,19,21)/b8-7+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375754
PNG
((E)-N-(2-aminophenyl)-3-(6-(ethoxymethyl)imidazo[2...)
Show SMILES CCOCc1cn2cc(\C=C\C(=O)Nc3ccccc3N)sc2n1
Show InChI InChI=1S/C17H18N4O2S/c1-2-23-11-12-9-21-10-13(24-17(21)19-12)7-8-16(22)20-15-6-4-3-5-14(15)18/h3-10H,2,11,18H2,1H3,(H,20,22)/b8-7+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375763
PNG
(US10301323, Compound A3 | US9908899, Compound A3)
Show SMILES Cc1ncc(\C=C\C(=O)Nc2ccccc2N)s1
Show InChI InChI=1S/C13H13N3OS/c1-9-15-8-10(18-9)6-7-13(17)16-12-5-3-2-4-11(12)14/h2-8H,14H2,1H3,(H,16,17)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375763
PNG
(US10301323, Compound A3 | US9908899, Compound A3)
Show SMILES Cc1ncc(\C=C\C(=O)Nc2ccccc2N)s1
Show InChI InChI=1S/C13H13N3OS/c1-9-15-8-10(18-9)6-7-13(17)16-12-5-3-2-4-11(12)14/h2-8H,14H2,1H3,(H,16,17)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375762
PNG
(US10301323, Compound A1 | US9908899, Compound A1)
Show SMILES Cc1nc(\C=C\C(=O)Nc2ccccc2N)cs1
Show InChI InChI=1S/C13H13N3OS/c1-9-15-10(8-18-9)6-7-13(17)16-12-5-3-2-4-11(12)14/h2-8H,14H2,1H3,(H,16,17)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375738
PNG
(US10301323, Compound A12 | US9908899, Compound A12)
Show SMILES Cn1cnc(\C=C\C(=O)Nc2ccccc2N)c1
Show InChI InChI=1S/C13H14N4O/c1-17-8-10(15-9-17)6-7-13(18)16-12-5-3-2-4-11(12)14/h2-9H,14H2,1H3,(H,16,18)/b7-6+
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BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375765
PNG
(US10301323, Compound A5 | US9908899, Compound A5)
Show SMILES Cc1cc(\C=C\C(=O)Nc2ccccc2N)on1
Show InChI InChI=1S/C13H13N3O2/c1-9-8-10(18-16-9)6-7-13(17)15-12-5-3-2-4-11(12)14/h2-8H,14H2,1H3,(H,15,17)/b7-6+
PDB
MMDB

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US Patent
n/an/a 1.50E+4n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375755
PNG
(US10301323, Compound A2 | US9908899, Compound A2)
Show SMILES Cn1cc(\C=C\C(=O)Nc2ccccc2N)cn1
Show InChI InChI=1S/C13H14N4O/c1-17-9-10(8-15-17)6-7-13(18)16-12-5-3-2-4-11(12)14/h2-9H,14H2,1H3,(H,16,18)/b7-6+
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n/an/a 1.50E+4n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375765
PNG
(US10301323, Compound A5 | US9908899, Compound A5)
Show SMILES Cc1cc(\C=C\C(=O)Nc2ccccc2N)on1
Show InChI InChI=1S/C13H13N3O2/c1-9-8-10(18-16-9)6-7-13(17)15-12-5-3-2-4-11(12)14/h2-8H,14H2,1H3,(H,15,17)/b7-6+
PDB
MMDB

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US Patent
n/an/a 1.50E+4n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375764
PNG
(US10301323, Compound A4 | US9908899, Compound A4)
Show SMILES Cc1nc(\C=C\C(=O)Nc2ccccc2N)co1
Show InChI InChI=1S/C13H13N3O2/c1-9-15-10(8-18-9)6-7-13(17)16-12-5-3-2-4-11(12)14/h2-8H,14H2,1H3,(H,16,17)/b7-6+
PDB
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US Patent
n/an/a>2.00E+4n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375764
PNG
(US10301323, Compound A4 | US9908899, Compound A4)
Show SMILES Cc1nc(\C=C\C(=O)Nc2ccccc2N)co1
Show InChI InChI=1S/C13H13N3O2/c1-9-15-10(8-18-9)6-7-13(17)16-12-5-3-2-4-11(12)14/h2-8H,14H2,1H3,(H,16,17)/b7-6+
PDB
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US Patent
n/an/a>2.00E+4n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM375757
PNG
(US10301323, Compound C2 | US9908899, Compound C2)
Show SMILES Cn1cc(\C=C\C(=O)Nc2ccc(F)cc2N)cn1
Show InChI InChI=1S/C13H13FN4O/c1-18-8-9(7-16-18)2-5-13(19)17-12-4-3-10(14)6-11(12)15/h2-8H,15H2,1H3,(H,17,19)/b5-2+
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US Patent
n/an/a>2.00E+4n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM375757
PNG
(US10301323, Compound C2 | US9908899, Compound C2)
Show SMILES Cn1cc(\C=C\C(=O)Nc2ccc(F)cc2N)cn1
Show InChI InChI=1S/C13H13FN4O/c1-18-8-9(7-16-18)2-5-13(19)17-12-4-3-10(14)6-11(12)15/h2-8H,15H2,1H3,(H,17,19)/b5-2+
PDB
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US Patent
n/an/a>2.00E+4n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10301323 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%