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Patent code US10307426

Compile Data Set for Download or QSAR
Found 36 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM394352
PNG
(N-[3-[2-(difluoromethoxy)-5- (difluoromethyl)pheny...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(ccc1OC(F)F)C(F)F
Show InChI InChI=1S/C22H19F4N7O3/c1-31(2)17(34)11-32-10-15(29-21(35)14-9-28-33-7-3-6-27-20(14)33)18(30-32)13-8-12(19(23)24)4-5-16(13)36-22(25)26/h3-10,19,22H,11H2,1-2H3,(H,29,35)
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0.150n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM394296
PNG
(N-[3-[2-(difluoromethoxy)-5-iodo- phenyl]-1-[2-(di...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(I)ccc1OC(F)F
Show InChI InChI=1S/C21H18F2IN7O3/c1-29(2)17(32)11-30-10-15(27-20(33)14-9-26-31-7-3-6-25-19(14)31)18(28-30)13-8-12(24)4-5-16(13)34-21(22)23/h3-10,21H,11H2,1-2H3,(H,27,33)
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0.170n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM394350
PNG
(N-[3-[5-(1,2-difluoroethyl)-2- (difluoromethoxy)ph...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(ccc1OC(F)F)C(F)CF
Show InChI InChI=1S/C23H21F4N7O3/c1-32(2)19(35)12-33-11-17(30-22(36)15-10-29-34-7-3-6-28-21(15)34)20(31-33)14-8-13(16(25)9-24)4-5-18(14)37-23(26)27/h3-8,10-11,16,23H,9,12H2,1-2H3,(H,30,36)
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0.170n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM394291
PNG
(N-[3-[2-(difluoromethoxy)-5-[rac- (1R,2R)-2-cyanoc...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(ccc1OC(F)F)[C@@H]1C[C@H]1C#N
Show InChI InChI=1S/C25H22F2N8O3/c1-33(2)21(36)13-34-12-19(31-24(37)18-11-30-35-7-3-6-29-23(18)35)22(32-34)17-8-14(16-9-15(16)10-28)4-5-20(17)38-25(26)27/h3-8,11-12,15-16,25H,9,13H2,1-2H3,(H,31,37)/t15-,16-/m0/s1
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0.25n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM394296
PNG
(N-[3-[2-(difluoromethoxy)-5-iodo- phenyl]-1-[2-(di...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(I)ccc1OC(F)F
Show InChI InChI=1S/C21H18F2IN7O3/c1-29(2)17(32)11-30-10-15(27-20(33)14-9-26-31-7-3-6-25-19(14)31)18(28-30)13-8-12(24)4-5-16(13)34-21(22)23/h3-10,21H,11H2,1-2H3,(H,27,33)
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0.25n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM394352
PNG
(N-[3-[2-(difluoromethoxy)-5- (difluoromethyl)pheny...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(ccc1OC(F)F)C(F)F
Show InChI InChI=1S/C22H19F4N7O3/c1-31(2)17(34)11-32-10-15(29-21(35)14-9-28-33-7-3-6-27-20(14)33)18(30-32)13-8-12(19(23)24)4-5-16(13)36-22(25)26/h3-10,19,22H,11H2,1-2H3,(H,29,35)
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0.25n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM394375
PNG
(N-[3-[2,5- bis(difluoromethoxy)phenyl]-1-[2- (dime...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(OC(F)F)ccc1OC(F)F
Show InChI InChI=1S/C22H19F4N7O4/c1-31(2)17(34)11-32-10-15(29-20(35)14-9-28-33-7-3-6-27-19(14)33)18(30-32)13-8-12(36-21(23)24)4-5-16(13)37-22(25)26/h3-10,21-22H,11H2,1-2H3,(H,29,35)
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0.260n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM394370
PNG
(N-[3-[2-(difluoromethoxy)-5-(1,2,3,4- tetrahydrois...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Oc2ccc3CCNCc3c2)ccc1OC(F)F
Show InChI InChI=1S/C30H28F2N8O4/c1-38(2)26(41)17-39-16-24(36-29(42)23-15-35-40-11-3-9-34-28(23)40)27(37-39)22-13-21(6-7-25(22)44-30(31)32)43-20-5-4-18-8-10-33-14-19(18)12-20/h3-7,9,11-13,15-16,30,33H,8,10,14,17H2,1-2H3,(H,36,42)
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0.270n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM394373
PNG
(N-[3-[5-bromo-2- (difluoromethoxy)phenyl]-1-[2- (d...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Br)ccc1OC(F)F
Show InChI InChI=1S/C21H18BrF2N7O3/c1-29(2)17(32)11-30-10-15(27-20(33)14-9-26-31-7-3-6-25-19(14)31)18(28-30)13-8-12(22)4-5-16(13)34-21(23)24/h3-10,21H,11H2,1-2H3,(H,27,33)
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0.320n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM394310
PNG
(2-amino-N-[3-[5-chloro-2- (difluoromethoxy)phenyl]...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C21H19ClF2N8O3/c1-30(2)15(33)10-31-9-13(17(28-31)12-8-11(22)4-5-14(12)35-21(23)24)27-20(34)16-18(25)29-32-7-3-6-26-19(16)32/h3-9,21H,10H2,1-2H3,(H2,25,29)(H,27,34)
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0.340n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM394350
PNG
(N-[3-[5-(1,2-difluoroethyl)-2- (difluoromethoxy)ph...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(ccc1OC(F)F)C(F)CF
Show InChI InChI=1S/C23H21F4N7O3/c1-32(2)19(35)12-33-11-17(30-22(36)15-10-29-34-7-3-6-28-21(15)34)20(31-33)14-8-13(16(25)9-24)4-5-18(14)37-23(26)27/h3-8,10-11,16,23H,9,12H2,1-2H3,(H,30,36)
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0.380n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM394368
PNG
(N-[3-[5-chloro-2- (difluoromethoxy)phenyl]-1-[2- (...)
Show SMILES CC(C(=O)N(C)C)n1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C22H20ClF2N7O3/c1-12(21(34)30(2)3)32-11-16(28-20(33)15-10-27-31-8-4-7-26-19(15)31)18(29-32)14-9-13(23)5-6-17(14)35-22(24)25/h4-12,22H,1-3H3,(H,28,33)
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0.410n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM394373
PNG
(N-[3-[5-bromo-2- (difluoromethoxy)phenyl]-1-[2- (d...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Br)ccc1OC(F)F
Show InChI InChI=1S/C21H18BrF2N7O3/c1-29(2)17(32)11-30-10-15(27-20(33)14-9-26-31-7-3-6-25-19(14)31)18(28-30)13-8-12(22)4-5-16(13)34-21(23)24/h3-10,21H,11H2,1-2H3,(H,27,33)
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0.430n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM394371
PNG
(N-[3-[2-(difluoromethoxy)-5-vinyl- phenyl]-1-[2-(d...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(C=C)ccc1OC(F)F
Show InChI InChI=1S/C23H21F2N7O3/c1-4-14-6-7-18(35-23(24)25)15(10-14)20-17(12-31(29-20)13-19(33)30(2)3)28-22(34)16-11-27-32-9-5-8-26-21(16)32/h4-12,23H,1,13H2,2-3H3,(H,28,34)
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0.510n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM394365
PNG
(N-[3-[5-(2,2-difluoroethyl)-2- (difluoromethoxy)ph...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(CC(F)F)ccc1OC(F)F
Show InChI InChI=1S/C23H21F4N7O3/c1-32(2)19(35)12-33-11-16(30-22(36)15-10-29-34-7-3-6-28-21(15)34)20(31-33)14-8-13(9-18(24)25)4-5-17(14)37-23(26)27/h3-8,10-11,18,23H,9,12H2,1-2H3,(H,30,36)
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0.520n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM394368
PNG
(N-[3-[5-chloro-2- (difluoromethoxy)phenyl]-1-[2- (...)
Show SMILES CC(C(=O)N(C)C)n1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C22H20ClF2N7O3/c1-12(21(34)30(2)3)32-11-16(28-20(33)15-10-27-31-8-4-7-26-19(15)31)18(29-32)14-9-13(23)5-6-17(14)35-22(24)25/h4-12,22H,1-3H3,(H,28,33)
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0.580n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM394291
PNG
(N-[3-[2-(difluoromethoxy)-5-[rac- (1R,2R)-2-cyanoc...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(ccc1OC(F)F)[C@@H]1C[C@H]1C#N
Show InChI InChI=1S/C25H22F2N8O3/c1-33(2)21(36)13-34-12-19(31-24(37)18-11-30-35-7-3-6-29-23(18)35)22(32-34)17-8-14(16-9-15(16)10-28)4-5-20(17)38-25(26)27/h3-8,11-12,15-16,25H,9,13H2,1-2H3,(H,31,37)/t15-,16-/m0/s1
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0.610n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM394374
PNG
(N-[3-[5-chloro-2- (difluoromethoxy)phenyl]-1-[2- (...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C21H18ClF2N7O3/c1-29(2)17(32)11-30-10-15(27-20(33)14-9-26-31-7-3-6-25-19(14)31)18(28-30)13-8-12(22)4-5-16(13)34-21(23)24/h3-10,21H,11H2,1-2H3,(H,27,33)
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0.650n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM394375
PNG
(N-[3-[2,5- bis(difluoromethoxy)phenyl]-1-[2- (dime...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(OC(F)F)ccc1OC(F)F
Show InChI InChI=1S/C22H19F4N7O4/c1-31(2)17(34)11-32-10-15(29-20(35)14-9-28-33-7-3-6-27-19(14)33)18(30-32)13-8-12(36-21(23)24)4-5-16(13)37-22(25)26/h3-10,21-22H,11H2,1-2H3,(H,29,35)
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0.720n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM394370
PNG
(N-[3-[2-(difluoromethoxy)-5-(1,2,3,4- tetrahydrois...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Oc2ccc3CCNCc3c2)ccc1OC(F)F
Show InChI InChI=1S/C30H28F2N8O4/c1-38(2)26(41)17-39-16-24(36-29(42)23-15-35-40-11-3-9-34-28(23)40)27(37-39)22-13-21(6-7-25(22)44-30(31)32)43-20-5-4-18-8-10-33-14-19(18)12-20/h3-7,9,11-13,15-16,30,33H,8,10,14,17H2,1-2H3,(H,36,42)
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0.75n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM394310
PNG
(2-amino-N-[3-[5-chloro-2- (difluoromethoxy)phenyl]...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C21H19ClF2N8O3/c1-30(2)15(33)10-31-9-13(17(28-31)12-8-11(22)4-5-14(12)35-21(23)24)27-20(34)16-18(25)29-32-7-3-6-26-19(16)32/h3-9,21H,10H2,1-2H3,(H2,25,29)(H,27,34)
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0.770n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM394372
PNG
(N-[3-[5-cyclopropyl-2- (difluoromethoxy)phenyl]-1-...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(ccc1OC(F)F)C1CC1
Show InChI InChI=1S/C24H23F2N7O3/c1-31(2)20(34)13-32-12-18(29-23(35)17-11-28-33-9-3-8-27-22(17)33)21(30-32)16-10-15(14-4-5-14)6-7-19(16)36-24(25)26/h3,6-12,14,24H,4-5,13H2,1-2H3,(H,29,35)
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0.800n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM394368
PNG
(N-[3-[5-chloro-2- (difluoromethoxy)phenyl]-1-[2- (...)
Show SMILES CC(C(=O)N(C)C)n1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C22H20ClF2N7O3/c1-12(21(34)30(2)3)32-11-16(28-20(33)15-10-27-31-8-4-7-26-19(15)31)18(29-32)14-9-13(23)5-6-17(14)35-22(24)25/h4-12,22H,1-3H3,(H,28,33)
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0.830n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM394366
PNG
(N-[3-[2-(difluoromethoxy)-5-[4- (dimethylcarbamoyl...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Oc2ccc(cc2)C(=O)N(C)C)ccc1OC(F)F
Show InChI InChI=1S/C30H28F2N8O5/c1-37(2)25(41)17-39-16-23(35-28(42)22-15-34-40-13-5-12-33-27(22)40)26(36-39)21-14-20(10-11-24(21)45-30(31)32)44-19-8-6-18(7-9-19)29(43)38(3)4/h5-16,30H,17H2,1-4H3,(H,35,42)
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0.830n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM394367
PNG
(N-[3-[2-(difluoromethoxy)-5-(2- fluoroethyl)phenyl...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(CCF)ccc1OC(F)F
Show InChI InChI=1S/C23H22F3N7O3/c1-31(2)19(34)13-32-12-17(29-22(35)16-11-28-33-9-3-8-27-21(16)33)20(30-32)15-10-14(6-7-24)4-5-18(15)36-23(25)26/h3-5,8-12,23H,6-7,13H2,1-2H3,(H,29,35)
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0.970n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM394374
PNG
(N-[3-[5-chloro-2- (difluoromethoxy)phenyl]-1-[2- (...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C21H18ClF2N7O3/c1-29(2)17(32)11-30-10-15(27-20(33)14-9-26-31-7-3-6-25-19(14)31)18(28-30)13-8-12(22)4-5-16(13)34-21(23)24/h3-10,21H,11H2,1-2H3,(H,27,33)
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1.02n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM394365
PNG
(N-[3-[5-(2,2-difluoroethyl)-2- (difluoromethoxy)ph...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(CC(F)F)ccc1OC(F)F
Show InChI InChI=1S/C23H21F4N7O3/c1-32(2)19(35)12-33-11-16(30-22(36)15-10-29-34-7-3-6-28-21(15)34)20(31-33)14-8-13(9-18(24)25)4-5-17(14)37-23(26)27/h3-8,10-11,18,23H,9,12H2,1-2H3,(H,30,36)
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1.15n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM394371
PNG
(N-[3-[2-(difluoromethoxy)-5-vinyl- phenyl]-1-[2-(d...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(C=C)ccc1OC(F)F
Show InChI InChI=1S/C23H21F2N7O3/c1-4-14-6-7-18(35-23(24)25)15(10-14)20-17(12-31(29-20)13-19(33)30(2)3)28-22(34)16-11-27-32-9-5-8-26-21(16)32/h4-12,23H,1,13H2,2-3H3,(H,28,34)
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1.17n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM394368
PNG
(N-[3-[5-chloro-2- (difluoromethoxy)phenyl]-1-[2- (...)
Show SMILES CC(C(=O)N(C)C)n1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F
Show InChI InChI=1S/C22H20ClF2N7O3/c1-12(21(34)30(2)3)32-11-16(28-20(33)15-10-27-31-8-4-7-26-19(15)31)18(29-32)14-9-13(23)5-6-17(14)35-22(24)25/h4-12,22H,1-3H3,(H,28,33)
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1.26n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM394376
PNG
(N-(3-(2-(difluoromethoxy)-5-(3-(3- hydroxy-1-methy...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Oc2cccc(c2)C2(O)CN(C)C2)ccc1OC(F)F
Show InChI InChI=1S/C31H30F2N8O5/c1-38(2)26(42)16-40-15-24(36-29(43)23-14-35-41-11-5-10-34-28(23)41)27(37-40)22-13-21(8-9-25(22)46-30(32)33)45-20-7-4-6-19(12-20)31(44)17-39(3)18-31/h4-15,30,44H,16-18H2,1-3H3,(H,36,43)
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1.56n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM394366
PNG
(N-[3-[2-(difluoromethoxy)-5-[4- (dimethylcarbamoyl...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Oc2ccc(cc2)C(=O)N(C)C)ccc1OC(F)F
Show InChI InChI=1S/C30H28F2N8O5/c1-37(2)25(41)17-39-16-23(35-28(42)22-15-34-40-13-5-12-33-27(22)40)26(36-39)21-14-20(10-11-24(21)45-30(31)32)44-19-8-6-18(7-9-19)29(43)38(3)4/h5-16,30H,17H2,1-4H3,(H,35,42)
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1.81n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM394367
PNG
(N-[3-[2-(difluoromethoxy)-5-(2- fluoroethyl)phenyl...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(CCF)ccc1OC(F)F
Show InChI InChI=1S/C23H22F3N7O3/c1-31(2)19(34)13-32-12-17(29-22(35)16-11-28-33-9-3-8-27-21(16)33)20(30-32)15-10-14(6-7-24)4-5-18(15)36-23(25)26/h3-5,8-12,23H,6-7,13H2,1-2H3,(H,29,35)
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1.92n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM394372
PNG
(N-[3-[5-cyclopropyl-2- (difluoromethoxy)phenyl]-1-...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(ccc1OC(F)F)C1CC1
Show InChI InChI=1S/C24H23F2N7O3/c1-31(2)20(34)13-32-12-18(29-23(35)17-11-28-33-9-3-8-27-22(17)33)21(30-32)16-10-15(14-4-5-14)6-7-19(16)36-24(25)26/h3,6-12,14,24H,4-5,13H2,1-2H3,(H,29,35)
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1.99n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM394376
PNG
(N-(3-(2-(difluoromethoxy)-5-(3-(3- hydroxy-1-methy...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Oc2cccc(c2)C2(O)CN(C)C2)ccc1OC(F)F
Show InChI InChI=1S/C31H30F2N8O5/c1-38(2)26(42)16-40-15-24(36-29(43)23-14-35-41-11-5-10-34-28(23)41)27(37-40)22-13-21(8-9-25(22)46-30(32)33)45-20-7-4-6-19(12-20)31(44)17-39(3)18-31/h4-15,30,44H,16-18H2,1-3H3,(H,36,43)
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3.18n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM394350
PNG
(N-[3-[5-(1,2-difluoroethyl)-2- (difluoromethoxy)ph...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(ccc1OC(F)F)C(F)CF
Show InChI InChI=1S/C23H21F4N7O3/c1-32(2)19(35)12-33-11-17(30-22(36)15-10-29-34-7-3-6-28-21(15)34)20(31-33)14-8-13(16(25)9-24)4-5-18(14)37-23(26)27/h3-8,10-11,16,23H,9,12H2,1-2H3,(H,30,36)
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3.26n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM394350
PNG
(N-[3-[5-(1,2-difluoroethyl)-2- (difluoromethoxy)ph...)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(ccc1OC(F)F)C(F)CF
Show InChI InChI=1S/C23H21F4N7O3/c1-32(2)19(35)12-33-11-17(30-22(36)15-10-29-34-7-3-6-28-21(15)34)20(31-33)14-8-13(16(25)9-24)4-5-18(14)37-23(26)27/h3-8,10-11,16,23H,9,12H2,1-2H3,(H,30,36)
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5.84n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US10307426 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%