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Patent code US10308607

Compile Data Set for Download or QSAR
Found 3 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alpha-L-fucosidase I


(Homo sapiens (Human))
BDBM394396
PNG
(US10308607, Compound II)
Show SMILES O[C@@H]1[C@H](O)[C@H](CF)N[C@H](CNC(=O)c2cccc3-c4ccccc4C(=O)c23)[C@H]1O
Show InChI InChI=1S/C21H21FN2O5/c22-8-14-18(26)20(28)19(27)15(24-14)9-23-21(29)13-7-3-6-11-10-4-1-2-5-12(10)17(25)16(11)13/h1-7,14-15,18-20,24,26-28H,8-9H2,(H,23,29)/t14-,15+,18+,19+,20+/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 16n/an/an/an/an/an/a



HORIZON ORPHAN LLC

US Patent


Assay Description
Fucosidase inhibition was assessed by preparing a reaction mixture of 50 mM phosphate-citrate pH 4.5, 5 mM MgCl2, 640 nM 4-methylumbelliferyl-alpha-L...


US Patent US10308607 (2019)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens (Human))
BDBM394397
PNG
(US10308607, Compound III)
Show SMILES O[C@@H]1[C@H](O)[C@H](CF)N[C@@H](CNC(=O)c2cccc3-c4ccccc4C(=O)c23)[C@H]1O
Show InChI InChI=1S/C21H21FN2O5/c22-8-14-18(26)20(28)19(27)15(24-14)9-23-21(29)13-7-3-6-11-10-4-1-2-5-12(10)17(25)16(11)13/h1-7,14-15,18-20,24,26-28H,8-9H2,(H,23,29)/t14-,15-,18+,19+,20+/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 59n/an/an/an/an/an/a



HORIZON ORPHAN LLC

US Patent


Assay Description
Fucosidase inhibition was assessed by preparing a reaction mixture of 50 mM phosphate-citrate pH 4.5, 5 mM MgCl2, 640 nM 4-methylumbelliferyl-alpha-L...


US Patent US10308607 (2019)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens (Human))
BDBM394398
PNG
(US10308607, Compound IV)
Show SMILES C[C@@H]1N\C(=C/C(=O)Nc2cccc3-c4ccccc4C(=O)c23)[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C21H20N2O5/c1-10-18(25)21(28)20(27)15(22-10)9-16(24)23-14-8-4-7-12-11-5-2-3-6-13(11)19(26)17(12)14/h2-10,18,20-22,25,27-28H,1H3,(H,23,24)/b15-9-/t10-,18+,20+,21+/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.50E+3n/an/an/an/an/an/a



HORIZON ORPHAN LLC

US Patent


Assay Description
Fucosidase inhibition was assessed by preparing a reaction mixture of 50 mM phosphate-citrate pH 4.5, 5 mM MgCl2, 640 nM 4-methylumbelliferyl-alpha-L...


US Patent US10308607 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%