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Patent code US10308614

Compile Data Set for Download or QSAR

Found 304 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein polybromo-1


(Homo sapiens (Human))
BDBM394585
PNG
(2-(6-amino-5-(1-(1- | US10308614, Example 188)
Show SMILES CC(c1ccccc1)n1cc(cn1)-c1cc(nnc1N)-c1ccccc1O
Show InChI InChI=1S/C21H19N5O/c1-14(15-7-3-2-4-8-15)26-13-16(12-23-26)18-11-19(24-25-21(18)22)17-9-5-6-10-20(17)27/h2-14,27H,1H3,(H2,22,25)
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PC sid
UniChem
US Patent
n/an/a 2.5n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Histidine-Flag-PB1-BD5 Bromodomain645-766 (S645-D766; Swiss Prot Q86U86; mhhhhhhasdykddddkgslvpr\gsSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAI FLRLPSRSEL...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394450
PNG
(2-(6-amino-5-(8-(5- | US10308614, Example 51)
Show SMILES Nc1nnc(cc1N1CC2CCC(C1)N2c1cncc(F)c1)-c1ccccc1O
Show InChI InChI=1S/C21H21FN6O/c22-13-7-16(10-24-9-13)28-14-5-6-15(28)12-27(11-14)19-8-18(25-26-21(19)23)17-3-1-2-4-20(17)29/h1-4,7-10,14-15,29H,5-6,11-12H2,(H2,23,26)
MMDB

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PC sid
UniChem
US Patent
n/an/a 3.40n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Protein polybromo-1


(Homo sapiens (Human))
BDBM394584
PNG
(2-(6-amino-5-(1-methyl- | US10308614, Example 187)
Show SMILES Cn1cc(cn1)-c1cc(nnc1N)-c1ccccc1O
Show InChI InChI=1S/C14H13N5O/c1-19-8-9(7-16-19)11-6-12(17-18-14(11)15)10-4-2-3-5-13(10)20/h2-8,20H,1H3,(H2,15,18)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.70n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Histidine-Flag-PB1-BD5 Bromodomain645-766 (S645-D766; Swiss Prot Q86U86; mhhhhhhasdykddddkgslvpr\gsSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAI FLRLPSRSEL...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394468
PNG
(2-(6-amino-5-(8- | US10308614, Example 69)
Show SMILES Nc1nnc(cc1N1CC2CCC(C1)N2c1ccccn1)-c1ccccc1O
Show InChI InChI=1S/C21H22N6O/c22-21-18(11-17(24-25-21)16-5-1-2-6-19(16)28)26-12-14-8-9-15(13-26)27(14)20-7-3-4-10-23-20/h1-7,10-11,14-15,28H,8-9,12-13H2,(H2,22,25)
MMDB

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PC sid
UniChem
US Patent
n/an/a 3.90n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394474
PNG
(2-(6-amino-5-(8-(5- | US10308614, Example 75)
Show SMILES Nc1nnc(cc1N1CC2CCC(C1)N2c1ccc(F)cn1)-c1ccccc1O
Show InChI InChI=1S/C21H21FN6O/c22-13-5-8-20(24-10-13)28-14-6-7-15(28)12-27(11-14)18-9-17(25-26-21(18)23)16-3-1-2-4-19(16)29/h1-5,8-10,14-15,29H,6-7,11-12H2,(H2,23,26)
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PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394469
PNG
(2-(6-amino-5-(8-(pyridin- | US10308614, Example 70)
Show SMILES Nc1nnc(cc1N1CC2CCC(C1)N2c1cccnc1)-c1ccccc1O
Show InChI InChI=1S/C21H22N6O/c22-21-19(10-18(24-25-21)17-5-1-2-6-20(17)28)26-12-15-7-8-16(13-26)27(15)14-4-3-9-23-11-14/h1-6,9-11,15-16,28H,7-8,12-13H2,(H2,22,25)
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UniChem
US Patent
n/an/a 4.10n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394462
PNG
(2-(6-amino-5-(8-phenyl-3,8- | US10308614, Example ...)
Show SMILES Nc1nnc(cc1N1CC2CCC(C1)N2c1ccccc1)-c1ccccc1O
Show InChI InChI=1S/C22H23N5O/c23-22-20(12-19(24-25-22)18-8-4-5-9-21(18)28)26-13-16-10-11-17(14-26)27(16)15-6-2-1-3-7-15/h1-9,12,16-17,28H,10-11,13-14H2,(H2,23,25)
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PC sid
UniChem
US Patent
n/an/a 4.30n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394446
PNG
(2-(6-amino-5-(8-(2- | US10308614, Example 47)
Show SMILES Nc1nnc(cc1N1CC2CCC(C1)N2c1ccnc(F)c1)-c1ccccc1O
Show InChI InChI=1S/C21H21FN6O/c22-20-9-13(7-8-24-20)28-14-5-6-15(28)12-27(11-14)18-10-17(25-26-21(18)23)16-3-1-2-4-19(16)29/h1-4,7-10,14-15,29H,5-6,11-12H2,(H2,23,26)
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PC sid
UniChem
US Patent
n/an/a 4.5n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394470
PNG
(2-(6-amino-5-(8- | US10308614, Example 71)
Show SMILES Nc1nnc(cc1N1CC2CCC(C1)N2c1ncccn1)-c1ccccc1O
Show InChI InChI=1S/C20H21N7O/c21-19-17(10-16(24-25-19)15-4-1-2-5-18(15)28)26-11-13-6-7-14(12-26)27(13)20-22-8-3-9-23-20/h1-5,8-10,13-14,28H,6-7,11-12H2,(H2,21,25)
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UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Protein polybromo-1


(Homo sapiens (Human))
BDBM394605
PNG
(2-(6-amino-5-cyclohexylpyridazin-3-yl)phenol | US1...)
Show SMILES Nc1nnc(cc1C1CCCCC1)-c1ccccc1O
Show InChI InChI=1S/C16H19N3O/c17-16-13(11-6-2-1-3-7-11)10-14(18-19-16)12-8-4-5-9-15(12)20/h4-5,8-11,20H,1-3,6-7H2,(H2,17,19)
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PC sid
UniChem
US Patent
n/an/a 5.20n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Histidine-Flag-PB1-BD5 Bromodomain645-766 (S645-D766; Swiss Prot Q86U86; mhhhhhhasdykddddkgslvpr\gsSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAI FLRLPSRSEL...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Protein polybromo-1


(Homo sapiens (Human))
BDBM394575
PNG
(2-(6-amino-5-(2- | US10308614, Example 178)
Show SMILES CC(COc1cc(nnc1N)-c1ccccc1O)c1ccccc1
Show InChI InChI=1S/C19H19N3O2/c1-13(14-7-3-2-4-8-14)12-24-18-11-16(21-22-19(18)20)15-9-5-6-10-17(15)23/h2-11,13,23H,12H2,1H3,(H2,20,22)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.30n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Histidine-Flag-PB1-BD5 Bromodomain645-766 (S645-D766; Swiss Prot Q86U86; mhhhhhhasdykddddkgslvpr\gsSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAI FLRLPSRSEL...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))
BDBM394585
PNG
(2-(6-amino-5-(1-(1- | US10308614, Example 188)
Show SMILES CC(c1ccccc1)n1cc(cn1)-c1cc(nnc1N)-c1ccccc1O
Show InChI InChI=1S/C21H19N5O/c1-14(15-7-3-2-4-8-15)26-13-16(12-23-26)18-11-19(24-25-21(18)22)17-9-5-6-10-20(17)27/h2-14,27H,1H3,(H2,22,25)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.70n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394589
PNG
(2-(6-amino-5-(1-(1- | US10308614, Example 192)
Show SMILES CC(c1ccccc1)n1cnc(c1)-c1cc(nnc1N)-c1ccccc1O
Show InChI InChI=1S/C21H19N5O/c1-14(15-7-3-2-4-8-15)26-12-19(23-13-26)17-11-18(24-25-21(17)22)16-9-5-6-10-20(16)27/h2-14,27H,1H3,(H2,22,25)
MMDB

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GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.30n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394476
PNG
(2-(6-amino-5-(8-(thiazol- | US10308614, Example 77)
Show SMILES Nc1nnc(cc1N1CC2CCC(C1)N2c1nccs1)-c1ccccc1O
Show InChI InChI=1S/C19H20N6OS/c20-18-16(9-15(22-23-18)14-3-1-2-4-17(14)26)24-10-12-5-6-13(11-24)25(12)19-21-7-8-27-19/h1-4,7-9,12-13,26H,5-6,10-11H2,(H2,20,23)
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PC sid
UniChem
US Patent
n/an/a 6.5n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394585
PNG
(2-(6-amino-5-(1-(1- | US10308614, Example 188)
Show SMILES CC(c1ccccc1)n1cc(cn1)-c1cc(nnc1N)-c1ccccc1O
Show InChI InChI=1S/C21H19N5O/c1-14(15-7-3-2-4-8-15)26-13-16(12-23-26)18-11-19(24-25-21(18)22)17-9-5-6-10-20(17)27/h2-14,27H,1H3,(H2,22,25)
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 6.60n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394475
PNG
(2-(6-amino-5-(8-(4- | US10308614, Example 76)
Show SMILES Nc1nnc(cc1N1CC2CCC(C1)N2c1ccc(F)cc1)-c1ccccc1O
Show InChI InChI=1S/C22H22FN5O/c23-14-5-7-15(8-6-14)28-16-9-10-17(28)13-27(12-16)20-11-19(25-26-22(20)24)18-3-1-2-4-21(18)29/h1-8,11,16-17,29H,9-10,12-13H2,(H2,24,26)
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PC sid
UniChem
US Patent
n/an/a 6.70n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Protein polybromo-1


(Homo sapiens (Human))
BDBM394528
PNG
(1-(4-(3-amino-6-(2- | US10308614, Example 129)
Show SMILES CC1CN(CCN1C(=O)C(C)(C)C)c1cc(nnc1N)-c1ccccc1O
Show InChI InChI=1S/C20H27N5O2/c1-13-12-24(9-10-25(13)19(27)20(2,3)4)16-11-15(22-23-18(16)21)14-7-5-6-8-17(14)26/h5-8,11,13,26H,9-10,12H2,1-4H3,(H2,21,23)
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PC sid
UniChem
US Patent
n/an/a 6.80n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Histidine-Flag-PB1-BD5 Bromodomain645-766 (S645-D766; Swiss Prot Q86U86; mhhhhhhasdykddddkgslvpr\gsSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAI FLRLPSRSEL...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))
BDBM394575
PNG
(2-(6-amino-5-(2- | US10308614, Example 178)
Show SMILES CC(COc1cc(nnc1N)-c1ccccc1O)c1ccccc1
Show InChI InChI=1S/C19H19N3O2/c1-13(14-7-3-2-4-8-14)12-24-18-11-16(21-22-19(18)20)15-9-5-6-10-17(15)23/h2-11,13,23H,12H2,1H3,(H2,20,22)
GoogleScholar
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PC sid
UniChem
US Patent
n/an/a 7.20n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394427
PNG
((trans-4a,8a)-2-(3-amino-6- | US10308614, Example ...)
Show SMILES Nc1nnc(cc1N1CC[C@@]2(O)CCCC[C@@H]2C1)-c1ccccc1O
Show InChI InChI=1S/C19H24N4O2/c20-18-16(11-15(21-22-18)14-6-1-2-7-17(14)24)23-10-9-19(25)8-4-3-5-13(19)12-23/h1-2,6-7,11,13,24-25H,3-5,8-10,12H2,(H2,20,22)/t13-,19+/m1/s1
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UniChem
US Patent
n/an/a 8.40n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Protein polybromo-1


(Homo sapiens (Human))
BDBM394571
PNG
(2-(6-amino-5- | US10308614, Example 174)
Show SMILES Nc1nnc(cc1OCCc1ccccc1)-c1ccccc1O
Show InChI InChI=1S/C18H17N3O2/c19-18-17(23-11-10-13-6-2-1-3-7-13)12-15(20-21-18)14-8-4-5-9-16(14)22/h1-9,12,22H,10-11H2,(H2,19,21)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8.80n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Histidine-Flag-PB1-BD5 Bromodomain645-766 (S645-D766; Swiss Prot Q86U86; mhhhhhhasdykddddkgslvpr\gsSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAI FLRLPSRSEL...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))
BDBM394605
PNG
(2-(6-amino-5-cyclohexylpyridazin-3-yl)phenol | US1...)
Show SMILES Nc1nnc(cc1C1CCCCC1)-c1ccccc1O
Show InChI InChI=1S/C16H19N3O/c17-16-13(11-6-2-1-3-7-11)10-14(18-19-16)12-8-4-5-9-15(12)20/h4-5,8-11,20H,1-3,6-7H2,(H2,17,19)
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n/an/a 8.80n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Protein polybromo-1


(Homo sapiens (Human))
BDBM394583
PNG
(2-(6-amino-5-phenylpyridazin-3-yl)phenol | US10308...)
Show SMILES Nc1nnc(cc1-c1ccccc1)-c1ccccc1O
Show InChI InChI=1S/C16H13N3O/c17-16-13(11-6-2-1-3-7-11)10-14(18-19-16)12-8-4-5-9-15(12)20/h1-10,20H,(H2,17,19)
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n/an/a 8.90n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Histidine-Flag-PB1-BD5 Bromodomain645-766 (S645-D766; Swiss Prot Q86U86; mhhhhhhasdykddddkgslvpr\gsSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAI FLRLPSRSEL...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Protein polybromo-1


(Homo sapiens (Human))
BDBM394567
PNG
((S)-2-(6-amino-5-(1- | US10308614, Example 170)
Show SMILES C[C@H](Oc1cc(nnc1N)-c1ccccc1O)c1ccccc1
Show InChI InChI=1S/C18H17N3O2/c1-12(13-7-3-2-4-8-13)23-17-11-15(20-21-18(17)19)14-9-5-6-10-16(14)22/h2-12,22H,1H3,(H2,19,21)/t12-/m0/s1
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n/an/a 9.60n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Histidine-Flag-PB1-BD5 Bromodomain645-766 (S645-D766; Swiss Prot Q86U86; mhhhhhhasdykddddkgslvpr\gsSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAI FLRLPSRSEL...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))
BDBM394584
PNG
(2-(6-amino-5-(1-methyl- | US10308614, Example 187)
Show SMILES Cn1cc(cn1)-c1cc(nnc1N)-c1ccccc1O
Show InChI InChI=1S/C14H13N5O/c1-19-8-9(7-16-19)11-6-12(17-18-14(11)15)10-4-2-3-5-13(10)20/h2-8,20H,1H3,(H2,15,18)
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n/an/a 10n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394528
PNG
(1-(4-(3-amino-6-(2- | US10308614, Example 129)
Show SMILES CC1CN(CCN1C(=O)C(C)(C)C)c1cc(nnc1N)-c1ccccc1O
Show InChI InChI=1S/C20H27N5O2/c1-13-12-24(9-10-25(13)19(27)20(2,3)4)16-11-15(22-23-18(16)21)14-7-5-6-8-17(14)26/h5-8,11,13,26H,9-10,12H2,1-4H3,(H2,21,23)
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n/an/a 10.4n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394473
PNG
(2-(6-amino-5-((1R,4R)-5- | US10308614, Example 74)
Show SMILES Nc1nnc(cc1N1C[C@H]2C[C@@H]1CN2c1ccccn1)-c1ccccc1O
Show InChI InChI=1S/C20H20N6O/c21-20-17(10-16(23-24-20)15-5-1-2-6-18(15)27)25-11-14-9-13(25)12-26(14)19-7-3-4-8-22-19/h1-8,10,13-14,27H,9,11-12H2,(H2,21,24)/t13-,14-/m1/s1
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n/an/a 10.6n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394449
PNG
(2-(6-amino-5-(8- | US10308614, Example 50)
Show SMILES Nc1nnc(cc1N1CC2CCC(C1)N2c1cnccn1)-c1ccccc1O
Show InChI InChI=1S/C20H21N7O/c21-20-17(9-16(24-25-20)15-3-1-2-4-18(15)28)26-11-13-5-6-14(12-26)27(13)19-10-22-7-8-23-19/h1-4,7-10,13-14,28H,5-6,11-12H2,(H2,21,25)
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n/an/a 10.6n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394485
PNG
(Enantiomer 1 and Enantiomer 2 of (trans-4a,8a)-2-(...)
Show SMILES Nc1nnc(cc1N1CC[C@]2(O)CCCC[C@@H]2C1)-c1ccccc1O
Show InChI InChI=1S/C19H24N4O2/c20-18-16(11-15(21-22-18)14-6-1-2-7-17(14)24)23-10-9-19(25)8-4-3-5-13(19)12-23/h1-2,6-7,11,13,24-25H,3-5,8-10,12H2,(H2,20,22)/t13-,19-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394441
PNG
(1-(3-amino-6-(2- | US10308614, Example 42)
Show SMILES Nc1nnc(cc1N1CCC(O)(CC1)c1ccccc1)-c1ccccc1O
Show InChI InChI=1S/C21H22N4O2/c22-20-18(14-17(23-24-20)16-8-4-5-9-19(16)26)25-12-10-21(27,11-13-25)15-6-2-1-3-7-15/h1-9,14,26-27H,10-13H2,(H2,22,24)
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n/an/a 11.3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394461
PNG
((4-(3-amino-6-(2- | US10308614, Example 62)
Show SMILES CC1CN(CCN1C(=O)c1ccccc1)c1cc(nnc1N)-c1ccccc1O
Show InChI InChI=1S/C22H23N5O2/c1-15-14-26(11-12-27(15)22(29)16-7-3-2-4-8-16)19-13-18(24-25-21(19)23)17-9-5-6-10-20(17)28/h2-10,13,15,28H,11-12,14H2,1H3,(H2,23,25)
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n/an/a 11.7n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394595
PNG
(2-(6-amino-5-(trans-2-phenylcyclopropyl)pyridazin-...)
Show SMILES Nc1nnc(cc1[C@@H]1C[C@H]1c1ccccc1)-c1ccccc1O
Show InChI InChI=1S/C19H17N3O/c20-19-16(15-10-14(15)12-6-2-1-3-7-12)11-17(21-22-19)13-8-4-5-9-18(13)23/h1-9,11,14-15,23H,10H2,(H2,20,22)/t14-,15+/m0/s1
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n/an/a 12.1n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394575
PNG
(2-(6-amino-5-(2- | US10308614, Example 178)
Show SMILES CC(COc1cc(nnc1N)-c1ccccc1O)c1ccccc1
Show InChI InChI=1S/C19H19N3O2/c1-13(14-7-3-2-4-8-14)12-24-18-11-16(21-22-19(18)20)15-9-5-6-10-17(15)23/h2-11,13,23H,12H2,1H3,(H2,20,22)
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n/an/a 12.2n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394537
PNG
((4-(3-amino-6-(2- | US10308614, Example 138)
Show SMILES CC1CN(CCN1C(=O)c1cncs1)c1cc(nnc1N)-c1ccccc1O
Show InChI InChI=1S/C19H20N6O2S/c1-12-10-24(6-7-25(12)19(27)17-9-21-11-28-17)15-8-14(22-23-18(15)20)13-4-2-3-5-16(13)26/h2-5,8-9,11-12,26H,6-7,10H2,1H3,(H2,20,23)
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n/an/a 12.6n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394584
PNG
(2-(6-amino-5-(1-methyl- | US10308614, Example 187)
Show SMILES Cn1cc(cn1)-c1cc(nnc1N)-c1ccccc1O
Show InChI InChI=1S/C14H13N5O/c1-19-8-9(7-16-19)11-6-12(17-18-14(11)15)10-4-2-3-5-13(10)20/h2-8,20H,1H3,(H2,15,18)
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n/an/a 12.8n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Protein polybromo-1


(Homo sapiens (Human))
BDBM394456
PNG
(2-(6-amino-5-(3- | US10308614, Example 57)
Show SMILES Nc1nnc(cc1N1CC(C1)Oc1ccccc1)-c1ccccc1O
Show InChI InChI=1S/C19H18N4O2/c20-19-17(10-16(21-22-19)15-8-4-5-9-18(15)24)23-11-14(12-23)25-13-6-2-1-3-7-13/h1-10,14,24H,11-12H2,(H2,20,22)
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n/an/a 13.3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Histidine-Flag-PB1-BD5 Bromodomain645-766 (S645-D766; Swiss Prot Q86U86; mhhhhhhasdykddddkgslvpr\gsSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAI FLRLPSRSEL...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Protein polybromo-1


(Homo sapiens (Human))
BDBM394490
PNG
(2-(6-amino-5-(piperidin-1-yl)pyridazin-3-yl)phenol...)
Show SMILES Nc1nnc(cc1N1CCCCC1)-c1ccccc1O
Show InChI InChI=1S/C15H18N4O/c16-15-13(19-8-4-1-5-9-19)10-12(17-18-15)11-6-2-3-7-14(11)20/h2-3,6-7,10,20H,1,4-5,8-9H2,(H2,16,18)
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n/an/a 13.9n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Histidine-Flag-PB1-BD5 Bromodomain645-766 (S645-D766; Swiss Prot Q86U86; mhhhhhhasdykddddkgslvpr\gsSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAI FLRLPSRSEL...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394605
PNG
(2-(6-amino-5-cyclohexylpyridazin-3-yl)phenol | US1...)
Show SMILES Nc1nnc(cc1C1CCCCC1)-c1ccccc1O
Show InChI InChI=1S/C16H19N3O/c17-16-13(11-6-2-1-3-7-11)10-14(18-19-16)12-8-4-5-9-15(12)20/h4-5,8-11,20H,1-3,6-7H2,(H2,17,19)
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n/an/a 14.5n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394571
PNG
(2-(6-amino-5- | US10308614, Example 174)
Show SMILES Nc1nnc(cc1OCCc1ccccc1)-c1ccccc1O
Show InChI InChI=1S/C18H17N3O2/c19-18-17(23-11-10-13-6-2-1-3-7-13)12-15(20-21-18)14-8-4-5-9-16(14)22/h1-9,12,22H,10-11H2,(H2,19,21)
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n/an/a 14.8n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Protein polybromo-1


(Homo sapiens (Human))
BDBM394606
PNG
(2-(6-amino-5- | US10308614, Example 210)
Show SMILES Nc1nnc(cc1C1CCCC1)-c1ccccc1O
Show InChI InChI=1S/C15H17N3O/c16-15-12(10-5-1-2-6-10)9-13(17-18-15)11-7-3-4-8-14(11)19/h3-4,7-10,19H,1-2,5-6H2,(H2,16,18)
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n/an/a 14.9n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Histidine-Flag-PB1-BD5 Bromodomain645-766 (S645-D766; Swiss Prot Q86U86; mhhhhhhasdykddddkgslvpr\gsSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAI FLRLPSRSEL...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))
BDBM394567
PNG
((S)-2-(6-amino-5-(1- | US10308614, Example 170)
Show SMILES C[C@H](Oc1cc(nnc1N)-c1ccccc1O)c1ccccc1
Show InChI InChI=1S/C18H17N3O2/c1-12(13-7-3-2-4-8-13)23-17-11-15(20-21-18(17)19)14-9-5-6-10-16(14)22/h2-12,22H,1H3,(H2,19,21)/t12-/m0/s1
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n/an/a 14.9n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394458
PNG
(1-(3-amino-6-(2- | US10308614, Example 59)
Show SMILES Nc1nnc(cc1N1CCCC(O)(C1)c1ccccc1)-c1ccccc1O
Show InChI InChI=1S/C21H22N4O2/c22-20-18(13-17(23-24-20)16-9-4-5-10-19(16)26)25-12-6-11-21(27,14-25)15-7-2-1-3-8-15/h1-5,7-10,13,26-27H,6,11-12,14H2,(H2,22,24)
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n/an/a 15.8n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Protein polybromo-1


(Homo sapiens (Human))
BDBM394507
PNG
(2-(6-amino-5-(3-methyl-4-(methylsulfonyl)piperazin...)
Show SMILES CC1CN(CCN1S(C)(=O)=O)c1cc(nnc1N)-c1ccccc1O
Show InChI InChI=1S/C16H21N5O3S/c1-11-10-20(7-8-21(11)25(2,23)24)14-9-13(18-19-16(14)17)12-5-3-4-6-15(12)22/h3-6,9,11,22H,7-8,10H2,1-2H3,(H2,17,19)
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n/an/a 15.9n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Histidine-Flag-PB1-BD5 Bromodomain645-766 (S645-D766; Swiss Prot Q86U86; mhhhhhhasdykddddkgslvpr\gsSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAI FLRLPSRSEL...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Protein polybromo-1


(Homo sapiens (Human))
BDBM394521
PNG
(1-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-2...)
Show SMILES CC1CN(CCN1C(C)=O)c1cc(nnc1N)-c1ccccc1O
Show InChI InChI=1S/C17H21N5O2/c1-11-10-21(7-8-22(11)12(2)23)15-9-14(19-20-17(15)18)13-5-3-4-6-16(13)24/h3-6,9,11,24H,7-8,10H2,1-2H3,(H2,18,20)
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US Patent
n/an/a 16.3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Histidine-Flag-PB1-BD5 Bromodomain645-766 (S645-D766; Swiss Prot Q86U86; mhhhhhhasdykddddkgslvpr\gsSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAI FLRLPSRSEL...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Protein polybromo-1


(Homo sapiens (Human))
BDBM394403
PNG
(2-(6-amino-5-(4-((dimethylami- | US10308614, Examp...)
Show SMILES CN(C)CC1CCN(CC1)c1cc(nnc1N)-c1ccccc1O
Show InChI InChI=1S/C18H25N5O/c1-22(2)12-13-7-9-23(10-8-13)16-11-15(20-21-18(16)19)14-5-3-4-6-17(14)24/h3-6,11,13,24H,7-10,12H2,1-2H3,(H2,19,21)
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US Patent
n/an/a 16.4n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Histidine-Flag-PB1-BD5 Bromodomain645-766 (S645-D766; Swiss Prot Q86U86; mhhhhhhasdykddddkgslvpr\gsSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAI FLRLPSRSEL...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394580
PNG
(2-(6-amino-5-((1- | US10308614, Example 183)
Show SMILES Nc1nnc(cc1OC1CCCN(C1)c1ccccc1)-c1ccccc1O
Show InChI InChI=1S/C21H22N4O2/c22-21-20(13-18(23-24-21)17-10-4-5-11-19(17)26)27-16-9-6-12-25(14-16)15-7-2-1-3-8-15/h1-5,7-8,10-11,13,16,26H,6,9,12,14H2,(H2,22,24)
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UniChem
US Patent
n/an/a 17.2n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394427
PNG
((trans-4a,8a)-2-(3-amino-6- | US10308614, Example ...)
Show SMILES Nc1nnc(cc1N1CC[C@@]2(O)CCCC[C@@H]2C1)-c1ccccc1O
Show InChI InChI=1S/C19H24N4O2/c20-18-16(11-15(21-22-18)14-6-1-2-7-17(14)24)23-10-9-19(25)8-4-3-5-13(19)12-23/h1-2,6-7,11,13,24-25H,3-5,8-10,12H2,(H2,20,22)/t13-,19+/m1/s1
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n/an/a 17.2n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394587
PNG
(2-(6-amino-5- | US10308614, Example 190)
Show SMILES Nc1nnc(cc1C1CC1)-c1ccccc1O
Show InChI InChI=1S/C13H13N3O/c14-13-10(8-5-6-8)7-11(15-16-13)9-3-1-2-4-12(9)17/h1-4,7-8,17H,5-6H2,(H2,14,16)
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n/an/a 17.6n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394424
PNG
(2-(6-amino-5-(4-methyl- | US10308614, Example 25)
Show SMILES CN1CCOC2(CCN(CC2)c2cc(nnc2N)-c2ccccc2O)C1
Show InChI InChI=1S/C19H25N5O2/c1-23-10-11-26-19(13-23)6-8-24(9-7-19)16-12-15(21-22-18(16)20)14-4-2-3-5-17(14)25/h2-5,12,25H,6-11,13H2,1H3,(H2,20,22)
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n/an/a 17.6n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394508
PNG
(2-(6-amino-5-(3-methyl- | US10308614, Example 109)
Show SMILES CC1CN(CCN1S(=O)(=O)c1ccccc1)c1cc(nnc1N)-c1ccccc1O
Show InChI InChI=1S/C21H23N5O3S/c1-15-14-25(11-12-26(15)30(28,29)16-7-3-2-4-8-16)19-13-18(23-24-21(19)22)17-9-5-6-10-20(17)27/h2-10,13,15,27H,11-12,14H2,1H3,(H2,22,24)
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n/an/a 17.6n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
Transcription activator BRG1


(Homo sapiens (Human))
BDBM394456
PNG
(2-(6-amino-5-(3- | US10308614, Example 57)
Show SMILES Nc1nnc(cc1N1CC(C1)Oc1ccccc1)-c1ccccc1O
Show InChI InChI=1S/C19H18N4O2/c20-19-17(10-16(21-22-19)15-8-4-5-9-18(15)24)23-11-14(12-23)25-13-6-2-1-3-7-13/h1-10,14,24H,11-12H2,(H2,20,22)
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n/an/a 17.7n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...


US Patent US10308614 (2019)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%