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Patent code US10308620

Compile Data Set for Download or QSAR
Found 74 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395158
PNG
(US10308620, Example 4)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccccc2)c2ccccc2O1
Show InChI InChI=1S/C22H24N2O3/c25-19-12-6-4-10-17(19)23-22(26)21-15-24(14-16-8-2-1-3-9-16)18-11-5-7-13-20(18)27-21/h1-3,5,7-9,11,13,15,17,19,25H,4,6,10,12,14H2,(H,23,26)/t17-,19-/m0/s1
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n/an/an/an/a 1.43E+3n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395175
PNG
(US10308620, Example 21)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccc(Cl)nc2)c2ccccc2O1
Show InChI InChI=1S/C21H22ClN3O3/c22-20-10-9-14(11-23-20)12-25-13-19(28-18-8-4-2-6-16(18)25)21(27)24-15-5-1-3-7-17(15)26/h2,4,6,8-11,13,15,17,26H,1,3,5,7,12H2,(H,24,27)/t15-,17-/m0/s1
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n/an/an/an/a 369n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395197
PNG
(US10308620, Example 44)
Show SMILES OCc1ccccc1NC(=O)C1=CN(Cc2cccc(F)c2F)c2cccc(F)c2O1
Show InChI InChI=1S/C23H17F3N2O3/c24-16-7-3-6-14(21(16)26)11-28-12-20(31-22-17(25)8-4-10-19(22)28)23(30)27-18-9-2-1-5-15(18)13-29/h1-10,12,29H,11,13H2,(H,27,30)
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n/an/an/an/a 1.28E+3n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395208
PNG
(US10308620, Example 57)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccncc2)c2cccc(F)c2O1
Show InChI InChI=1S/C21H22FN3O3/c22-15-4-3-6-17-20(15)28-19(13-25(17)12-14-8-10-23-11-9-14)21(27)24-16-5-1-2-7-18(16)26/h3-4,6,8-11,13,16,18,26H,1-2,5,7,12H2,(H,24,27)/t16-,18-/m0/s1
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n/an/an/an/a 179n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395212
PNG
(N-(3-Fluoropiperidin-4-yl)-4-(2-fluorobenzyl)-8-fl...)
Show SMILES FC1CNCCC1NC(=O)C1=CN(Cc2ccccc2F)c2cccc(F)c2O1
Show InChI InChI=1S/C21H20F3N3O2/c22-14-5-2-1-4-13(14)11-27-12-19(29-20-15(23)6-3-7-18(20)27)21(28)26-17-8-9-25-10-16(17)24/h1-7,12,16-17,25H,8-11H2,(H,26,28)
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n/an/an/an/a 2.37E+3n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395226
PNG
(US10308620, Example 95)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2cccc(F)c2)c2ccccc2S1=O
Show InChI InChI=1S/C22H23FN2O3S/c23-16-7-5-6-15(12-16)13-25-14-21(29(28)20-11-4-2-9-18(20)25)22(27)24-17-8-1-3-10-19(17)26/h2,4-7,9,11-12,14,17,19,26H,1,3,8,10,13H2,(H,24,27)/t17-,19-,29?/m0/s1
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n/an/an/an/a 1.52E+3n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395170
PNG
(US10308620, Example 16)
Show SMILES COc1ccc(CN2C=C(Oc3ccccc23)C(=O)NCC(C)(C)O)cn1
Show InChI InChI=1S/C20H23N3O4/c1-20(2,25)13-22-19(24)17-12-23(15-6-4-5-7-16(15)27-17)11-14-8-9-18(26-3)21-10-14/h4-10,12,25H,11,13H2,1-3H3,(H,22,24)
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n/an/an/an/a 1.35E+3n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395174
PNG
(US10308620, Example 20)
Show SMILES OC1COCCC1NC(=O)C1=CN(Cc2cccc(F)c2F)c2ccccc2O1
Show InChI InChI=1S/C21H20F2N2O4/c22-14-5-3-4-13(20(14)23)10-25-11-19(29-18-7-2-1-6-16(18)25)21(27)24-15-8-9-28-12-17(15)26/h1-7,11,15,17,26H,8-10,12H2,(H,24,27)
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n/an/an/an/a 1.25E+3n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395176
PNG
(US10308620, Example 22)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2cccnc2)c2ccccc2O1
Show InChI InChI=1S/C21H23N3O3/c25-18-9-3-1-7-16(18)23-21(26)20-14-24(13-15-6-5-11-22-12-15)17-8-2-4-10-19(17)27-20/h2,4-6,8,10-12,14,16,18,25H,1,3,7,9,13H2,(H,23,26)/t16-,18-/m0/s1
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n/an/an/an/a 353n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395201
PNG
(US10308620, Example 48)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccccc2)c2cccc(F)c2O1
Show InChI InChI=1S/C22H23FN2O3/c23-16-9-6-11-18-21(16)28-20(14-25(18)13-15-7-2-1-3-8-15)22(27)24-17-10-4-5-12-19(17)26/h1-3,6-9,11,14,17,19,26H,4-5,10,12-13H2,(H,24,27)/t17-,19-/m0/s1
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n/an/an/an/a 143n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395206
PNG
(US10308620, Example 55)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccccc2F)c2c(F)cccc2O1
Show InChI InChI=1S/C22H22F2N2O3/c23-15-7-2-1-6-14(15)12-26-13-20(29-19-11-5-8-16(24)21(19)26)22(28)25-17-9-3-4-10-18(17)27/h1-2,5-8,11,13,17-18,27H,3-4,9-10,12H2,(H,25,28)/t17-,18-/m0/s1
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n/an/an/an/a 828n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395210
PNG
(US10308620, Example 59)
Show SMILES Cn1ccc(n1)-c1cc(CN2C=C(Oc3ccccc23)C(=O)N[C@H]2CCCC[C@@H]2O)ccn1
Show InChI InChI=1S/C25H27N5O3/c1-29-13-11-18(28-29)20-14-17(10-12-26-20)15-30-16-24(33-23-9-5-3-7-21(23)30)25(32)27-19-6-2-4-8-22(19)31/h3,5,7,9-14,16,19,22,31H,2,4,6,8,15H2,1H3,(H,27,32)/t19-,22-/m0/s1
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n/an/an/an/a 1.01E+3n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395222
PNG
(US10308620, Example 91)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccc(Cl)nc2)c2ccccc2S1
Show InChI InChI=1S/C21H22ClN3O2S/c22-20-10-9-14(11-23-20)12-25-13-19(28-18-8-4-2-6-16(18)25)21(27)24-15-5-1-3-7-17(15)26/h2,4,6,8-11,13,15,17,26H,1,3,5,7,12H2,(H,24,27)/t15-,17-/m0/s1
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n/an/an/an/a 141n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395227
PNG
(US10308620, Example 96)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccccn2)c2ccccc2S1=O
Show InChI InChI=1S/C21H23N3O3S/c25-18-10-3-1-8-16(18)23-21(26)20-14-24(13-15-7-5-6-12-22-15)17-9-2-4-11-19(17)28(20)27/h2,4-7,9,11-12,14,16,18,25H,1,3,8,10,13H2,(H,23,26)/t16-,18-,28?/m0/s1
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n/an/an/an/a 2.16E+3n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395173
PNG
(US10308620, Example 19)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccc(F)c(F)c2)c2ccccc2O1
Show InChI InChI=1S/C22H22F2N2O3/c23-15-10-9-14(11-16(15)24)12-26-13-21(29-20-8-4-2-6-18(20)26)22(28)25-17-5-1-3-7-19(17)27/h2,4,6,8-11,13,17,19,27H,1,3,5,7,12H2,(H,25,28)/t17-,19-/m0/s1
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n/an/an/an/a 120n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395181
PNG
(US10308620, Example 27)
Show SMILES Cc1ncccc1CN1C=C(Oc2ccccc12)C(=O)N[C@H]1CCCC[C@@H]1O
Show InChI InChI=1S/C22H25N3O3/c1-15-16(7-6-12-23-15)13-25-14-21(28-20-11-5-3-9-18(20)25)22(27)24-17-8-2-4-10-19(17)26/h3,5-7,9,11-12,14,17,19,26H,2,4,8,10,13H2,1H3,(H,24,27)/t17-,19-/m0/s1
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n/an/an/an/a 1.37E+3n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395184
PNG
(US10308620, Example 30)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccccc2)c2ncccc2O1
Show InChI InChI=1S/C21H23N3O3/c25-17-10-5-4-9-16(17)23-21(26)19-14-24(13-15-7-2-1-3-8-15)20-18(27-19)11-6-12-22-20/h1-3,6-8,11-12,14,16-17,25H,4-5,9-10,13H2,(H,23,26)/t16-,17-/m0/s1
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n/an/an/an/a 955n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395189
PNG
(US10308620, Example 36)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2cccc(F)c2)c2cccnc2O1
Show InChI InChI=1S/C21H22FN3O3/c22-15-6-3-5-14(11-15)12-25-13-19(28-21-17(25)8-4-10-23-21)20(27)24-16-7-1-2-9-18(16)26/h3-6,8,10-11,13,16,18,26H,1-2,7,9,12H2,(H,24,27)/t16-,18-/m0/s1
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n/an/an/an/a 1.55E+3n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395195
PNG
(US10308620, Example 42)
Show SMILES O[C@@H]1CCC[C@H]1NC(=O)C1=CN(Cc2cccc(F)c2F)c2cccc(F)c2O1
Show InChI InChI=1S/C21H19F3N2O3/c22-13-5-1-4-12(19(13)24)10-26-11-18(21(28)25-15-7-3-9-17(15)27)29-20-14(23)6-2-8-16(20)26/h1-2,4-6,8,11,15,17,27H,3,7,9-10H2,(H,25,28)/t15-,17-/m1/s1
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n/an/an/an/a 686n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395198
PNG
(US10308620, Example 45)
Show SMILES OCc1ccccc1NC(=O)C1=CN(Cc2cccc(F)c2F)c2ccccc2O1
Show InChI InChI=1S/C23H18F2N2O3/c24-17-8-5-7-15(22(17)25)12-27-13-21(30-20-11-4-3-10-19(20)27)23(29)26-18-9-2-1-6-16(18)14-28/h1-11,13,28H,12,14H2,(H,26,29)
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n/an/an/an/a 1.58E+3n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395200
PNG
(US10308620, Example 47)
Show SMILES CC(C)C(CO)NC(=O)C1=CN(Cc2ccccc2F)c2cccc(F)c2O1
Show InChI InChI=1S/C21H22F2N2O3/c1-13(2)17(12-26)24-21(27)19-11-25(10-14-6-3-4-7-15(14)22)18-9-5-8-16(23)20(18)28-19/h3-9,11,13,17,26H,10,12H2,1-2H3,(H,24,27)
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n/an/an/an/a 1.32E+3n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395220
PNG
(US10308620, Example 89)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccc(F)cc2)c2ccccc2S1
Show InChI InChI=1S/C22H23FN2O2S/c23-16-11-9-15(10-12-16)13-25-14-21(28-20-8-4-2-6-18(20)25)22(27)24-17-5-1-3-7-19(17)26/h2,4,6,8-12,14,17,19,26H,1,3,5,7,13H2,(H,24,27)/t17-,19-/m0/s1
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n/an/an/an/a 460n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395228
PNG
(US10308620, Example 97)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccc(Cl)nc2)c2ccccc2S1=O
Show InChI InChI=1S/C21H22ClN3O3S/c22-20-10-9-14(11-23-20)12-25-13-19(29(28)18-8-4-2-6-16(18)25)21(27)24-15-5-1-3-7-17(15)26/h2,4,6,8-11,13,15,17,26H,1,3,5,7,12H2,(H,24,27)/t15-,17-,29?/m0/s1
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n/an/an/an/a 1.06E+3n/an/an/an/a



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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395171
PNG
(US10308620, Example 17)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2cccc(c2)C(F)(F)F)c2ccccc2O1
Show InChI InChI=1S/C23H23F3N2O3/c24-23(25,26)16-7-5-6-15(12-16)13-28-14-21(31-20-11-4-2-9-18(20)28)22(30)27-17-8-1-3-10-19(17)29/h2,4-7,9,11-12,14,17,19,29H,1,3,8,10,13H2,(H,27,30)/t17-,19-/m0/s1
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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395186
PNG
(US10308620, Example 33)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2cccc(F)c2F)c2ncccc2O1
Show InChI InChI=1S/C21H21F2N3O3/c22-14-6-3-5-13(19(14)23)11-26-12-18(29-17-9-4-10-24-20(17)26)21(28)25-15-7-1-2-8-16(15)27/h3-6,9-10,12,15-16,27H,1-2,7-8,11H2,(H,25,28)/t15-,16-/m0/s1
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n/an/an/an/a 1.18E+3n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395187
PNG
(US10308620, Example 34)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccncc2F)c2ccccc2O1
Show InChI InChI=1S/C21H22FN3O3/c22-15-11-23-10-9-14(15)12-25-13-20(28-19-8-4-2-6-17(19)25)21(27)24-16-5-1-3-7-18(16)26/h2,4,6,8-11,13,16,18,26H,1,3,5,7,12H2,(H,24,27)/t16-,18-/m0/s1
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n/an/an/an/a 1.52E+3n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395199
PNG
(US10308620, Example 46)
Show SMILES OCc1ccccc1NC(=O)C1=CN(Cc2ccccc2F)c2cccc(F)c2O1
Show InChI InChI=1S/C23H18F2N2O3/c24-17-8-3-1-6-15(17)12-27-13-21(30-22-18(25)9-5-11-20(22)27)23(29)26-19-10-4-2-7-16(19)14-28/h1-11,13,28H,12,14H2,(H,26,29)
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n/an/an/an/a 1.08E+3n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395216
PNG
(N-(cis-1S,2S-2-Hydroxycyclohexyl)-4-(2,3-difluorob...)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2cccc(F)c2F)c2ccccc2S1
Show InChI InChI=1S/C22H22F2N2O2S/c23-15-7-5-6-14(21(15)24)12-26-13-20(29-19-11-4-2-9-17(19)26)22(28)25-16-8-1-3-10-18(16)27/h2,4-7,9,11,13,16,18,27H,1,3,8,10,12H2,(H,25,28)/t16-,18-/m0/s1
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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395218
PNG
(US10308620, Example 87)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccccc2)c2ccccc2S1
Show InChI InChI=1S/C22H24N2O2S/c25-19-12-6-4-10-17(19)23-22(26)21-15-24(14-16-8-2-1-3-9-16)18-11-5-7-13-20(18)27-21/h1-3,5,7-9,11,13,15,17,19,25H,4,6,10,12,14H2,(H,23,26)/t17-,19-/m0/s1
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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395221
PNG
(US10308620, Example 90)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccncc2)c2ccccc2S1
Show InChI InChI=1S/C21H23N3O2S/c25-18-7-3-1-5-16(18)23-21(26)20-14-24(13-15-9-11-22-12-10-15)17-6-2-4-8-19(17)27-20/h2,4,6,8-12,14,16,18,25H,1,3,5,7,13H2,(H,23,26)/t16-,18-/m0/s1
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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395164
PNG
(US10308620, Example 10)
Show SMILES COc1cccc(CN2C=C(Oc3ccccc23)C(=O)NCC(C)(C)O)c1
Show InChI InChI=1S/C21H24N2O4/c1-21(2,25)14-22-20(24)19-13-23(17-9-4-5-10-18(17)27-19)12-15-7-6-8-16(11-15)26-3/h4-11,13,25H,12,14H2,1-3H3,(H,22,24)
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n/an/an/an/a 1.55E+3n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395179
PNG
(US10308620, Example 25)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccccn2)c2ccccc2O1
Show InChI InChI=1S/C21H23N3O3/c25-18-10-3-1-8-16(18)23-21(26)20-14-24(13-15-7-5-6-12-22-15)17-9-2-4-11-19(17)27-20/h2,4-7,9,11-12,14,16,18,25H,1,3,8,10,13H2,(H,23,26)/t16-,18-/m0/s1
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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395191
PNG
(US10308620, Example 38)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccccc2Cl)c2cccc(F)c2O1
Show InChI InChI=1S/C22H22ClFN2O3/c23-15-7-2-1-6-14(15)12-26-13-20(29-21-16(24)8-5-10-18(21)26)22(28)25-17-9-3-4-11-19(17)27/h1-2,5-8,10,13,17,19,27H,3-4,9,11-12H2,(H,25,28)/t17-,19-/m0/s1
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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395193
PNG
(US10308620, Example 40)
Show SMILES O[C@@H]1CCC[C@H]1NC(=O)C1=CN(Cc2ccccc2F)c2ccccc2O1
Show InChI InChI=1S/C21H21FN2O3/c22-15-7-2-1-6-14(15)12-24-13-20(27-19-11-4-3-9-17(19)24)21(26)23-16-8-5-10-18(16)25/h1-4,6-7,9,11,13,16,18,25H,5,8,10,12H2,(H,23,26)/t16-,18-/m1/s1
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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395194
PNG
(US10308620, Example 41)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccccc2Cl)c2ccccc2O1
Show InChI InChI=1S/C22H23ClN2O3/c23-16-8-2-1-7-15(16)13-25-14-21(28-20-12-6-4-10-18(20)25)22(27)24-17-9-3-5-11-19(17)26/h1-2,4,6-8,10,12,14,17,19,26H,3,5,9,11,13H2,(H,24,27)/t17-,19-/m0/s1
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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395202
PNG
(US10308620, Example 51)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2cccc(F)c2)c2cccc(F)c2O1
Show InChI InChI=1S/C22H22F2N2O3/c23-15-6-3-5-14(11-15)12-26-13-20(29-21-16(24)7-4-9-18(21)26)22(28)25-17-8-1-2-10-19(17)27/h3-7,9,11,13,17,19,27H,1-2,8,10,12H2,(H,25,28)/t17-,19-/m0/s1
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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395203
PNG
(US10308620, Example 52)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccnc(c2)-c2ccccc2)c2ccccc2O1
Show InChI InChI=1S/C27H27N3O3/c31-24-12-6-4-10-21(24)29-27(32)26-18-30(23-11-5-7-13-25(23)33-26)17-19-14-15-28-22(16-19)20-8-2-1-3-9-20/h1-3,5,7-9,11,13-16,18,21,24,31H,4,6,10,12,17H2,(H,29,32)/t21-,24-/m0/s1
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n/an/an/an/a 1.35E+3n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395209
PNG
(US10308620, Example 58)
Show SMILES Cc1cc(cnc1F)-c1cc(CN2C=C(Oc3ccccc23)C(=O)N[C@H]2CCCC[C@@H]2O)ccn1
Show InChI InChI=1S/C27H27FN4O3/c1-17-12-19(14-30-26(17)28)21-13-18(10-11-29-21)15-32-16-25(35-24-9-5-3-7-22(24)32)27(34)31-20-6-2-4-8-23(20)33/h3,5,7,9-14,16,20,23,33H,2,4,6,8,15H2,1H3,(H,31,34)/t20-,23-/m0/s1
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n/an/an/an/a 1.34E+3n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395213
PNG
(N-(3-Fluoropiperidin-4-yl)-4-(2,3-difluorobenzyl)-...)
Show SMILES FC1CNCCC1NC(=O)C1=CN(Cc2cccc(F)c2F)c2cccc(F)c2O1
Show InChI InChI=1S/C21H19F4N3O2/c22-13-4-1-3-12(19(13)25)10-28-11-18(30-20-14(23)5-2-6-17(20)28)21(29)27-16-7-8-26-9-15(16)24/h1-6,11,15-16,26H,7-10H2,(H,27,29)
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n/an/an/an/a 2.10E+3n/an/an/an/a



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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395219
PNG
(US10308620, Example 88)
Show SMILES COc1ccc(CN2C=C(Sc3ccccc23)C(=O)N[C@H]2CCCC[C@@H]2O)cc1
Show InChI InChI=1S/C23H26N2O3S/c1-28-17-12-10-16(11-13-17)14-25-15-22(29-21-9-5-3-7-19(21)25)23(27)24-18-6-2-4-8-20(18)26/h3,5,7,9-13,15,18,20,26H,2,4,6,8,14H2,1H3,(H,24,27)/t18-,20-/m0/s1
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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395224
PNG
(N-(cis-1S,2S-2-Hydroxycyclohexyl)-4-(2,3-difluorob...)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2cccc(F)c2F)c2ccccc2S1=O
Show InChI InChI=1S/C22H22F2N2O3S/c23-15-7-5-6-14(21(15)24)12-26-13-20(30(29)19-11-4-2-9-17(19)26)22(28)25-16-8-1-3-10-18(16)27/h2,4-7,9,11,13,16,18,27H,1,3,8,10,12H2,(H,25,28)/t16-,18-,30?/m0/s1
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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395155
PNG
(N-(cis-1S, 2S-2-Hydroxycyclohexyl)-4-(2-fluorobenz...)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccccc2F)c2ccccc2O1
Show InChI InChI=1S/C22H23FN2O3/c23-16-8-2-1-7-15(16)13-25-14-21(28-20-12-6-4-10-18(20)25)22(27)24-17-9-3-5-11-19(17)26/h1-2,4,6-8,10,12,14,17,19,26H,3,5,9,11,13H2,(H,24,27)/t17-,19-/m0/s1
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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395156
PNG
(US10308620, Example 2)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccccc2F)c2cccc(F)c2O1
Show InChI InChI=1S/C22H22F2N2O3/c23-15-7-2-1-6-14(15)12-26-13-20(29-21-16(24)8-5-10-18(21)26)22(28)25-17-9-3-4-11-19(17)27/h1-2,5-8,10,13,17,19,27H,3-4,9,11-12H2,(H,25,28)/t17-,19-/m0/s1
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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395159
PNG
(US10308620, Example 5)
Show SMILES COc1ccc(CN2C=C(Oc3ccccc23)C(=O)N[C@H]2CCCC[C@@H]2O)cc1
Show InChI InChI=1S/C23H26N2O4/c1-28-17-12-10-16(11-13-17)14-25-15-22(29-21-9-5-3-7-19(21)25)23(27)24-18-6-2-4-8-20(18)26/h3,5,7,9-13,15,18,20,26H,2,4,6,8,14H2,1H3,(H,24,27)/t18-,20-/m0/s1
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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395161
PNG
(US10308620, Example 7)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2cccc(F)c2)c2ccccc2O1
Show InChI InChI=1S/C22H23FN2O3/c23-16-7-5-6-15(12-16)13-25-14-21(28-20-11-4-2-9-18(20)25)22(27)24-17-8-1-3-10-19(17)26/h2,4-7,9,11-12,14,17,19,26H,1,3,8,10,13H2,(H,24,27)/t17-,19-/m0/s1
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n/an/an/an/a 891n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395167
PNG
(US10308620, Example 13)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccc(F)cc2)c2ccccc2O1
Show InChI InChI=1S/C22H23FN2O3/c23-16-11-9-15(10-12-16)13-25-14-21(28-20-8-4-2-6-18(20)25)22(27)24-17-5-1-3-7-19(17)26/h2,4,6,8-12,14,17,19,26H,1,3,5,7,13H2,(H,24,27)/t17-,19-/m0/s1
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SUVEN LIFE SCIENCES LIMITED

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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395168
PNG
(US10308620, Example 14)
Show SMILES CC(C)(O)CNC(=O)C1=CN(Cc2ccc(F)cc2)c2ccccc2O1
Show InChI InChI=1S/C20H21FN2O3/c1-20(2,25)13-22-19(24)18-12-23(11-14-7-9-15(21)10-8-14)16-5-3-4-6-17(16)26-18/h3-10,12,25H,11,13H2,1-2H3,(H,22,24)
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SUVEN LIFE SCIENCES LIMITED

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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395190
PNG
(US10308620, Example 37)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccccc2C(F)(F)F)c2ccccc2O1
Show InChI InChI=1S/C23H23F3N2O3/c24-23(25,26)16-8-2-1-7-15(16)13-28-14-21(31-20-12-6-4-10-18(20)28)22(30)27-17-9-3-5-11-19(17)29/h1-2,4,6-8,10,12,14,17,19,29H,3,5,9,11,13H2,(H,27,30)/t17-,19-/m0/s1
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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395192
PNG
(US10308620, Example 39)
Show SMILES O[C@@H]1CCC[C@H]1NC(=O)C1=CN(Cc2cccc(F)c2F)c2ccccc2O1
Show InChI InChI=1S/C21H20F2N2O3/c22-14-6-3-5-13(20(14)23)11-25-12-19(28-18-10-2-1-8-16(18)25)21(27)24-15-7-4-9-17(15)26/h1-3,5-6,8,10,12,15,17,26H,4,7,9,11H2,(H,24,27)/t15-,17-/m1/s1
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n/an/an/an/a 1.55E+3n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395196
PNG
(US10308620, Example 43)
Show SMILES OCc1ccccc1NC(=O)C1=CN(Cc2ccccc2F)c2ccccc2O1
Show InChI InChI=1S/C23H19FN2O3/c24-18-9-3-1-7-16(18)13-26-14-22(29-21-12-6-5-11-20(21)26)23(28)25-19-10-4-2-8-17(19)15-27/h1-12,14,27H,13,15H2,(H,25,28)
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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395215
PNG
(N-(3-Hydroxypiperidin-4-yl)-4-(2-fluorobenzyl)-4H-...)
Show SMILES OC1CNCCC1NC(=O)C1=CN(Cc2ccccc2F)c2ccccc2O1
Show InChI InChI=1S/C21H22FN3O3/c22-15-6-2-1-5-14(15)12-25-13-20(28-19-8-4-3-7-17(19)25)21(27)24-16-9-10-23-11-18(16)26/h1-8,13,16,18,23,26H,9-12H2,(H,24,27)
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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395162
PNG
(US10308620, Example 8)
Show SMILES CC(C)(O)CNC(=O)C1=CN(Cc2cccc(F)c2)c2ccccc2O1
Show InChI InChI=1S/C20H21FN2O3/c1-20(2,25)13-22-19(24)18-12-23(11-14-6-5-7-15(21)10-14)16-8-3-4-9-17(16)26-18/h3-10,12,25H,11,13H2,1-2H3,(H,22,24)
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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395165
PNG
(US10308620, Example 11)
Show SMILES COc1cc(CN2C=C(Oc3ccccc23)C(=O)N[C@H]2CCCC[C@@H]2O)ccn1
Show InChI InChI=1S/C22H25N3O4/c1-28-21-12-15(10-11-23-21)13-25-14-20(29-19-9-5-3-7-17(19)25)22(27)24-16-6-2-4-8-18(16)26/h3,5,7,9-12,14,16,18,26H,2,4,6,8,13H2,1H3,(H,24,27)/t16-,18-/m0/s1
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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395166
PNG
(US10308620, Example 12)
Show SMILES COc1cc(CN2C=C(Oc3ccccc23)C(=O)NCC(C)(C)O)ccn1
Show InChI InChI=1S/C20H23N3O4/c1-20(2,25)13-22-19(24)17-12-23(15-6-4-5-7-16(15)27-17)11-14-8-9-21-18(10-14)26-3/h4-10,12,25H,11,13H2,1-3H3,(H,22,24)
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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395172
PNG
(US10308620, Example 18)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2cccc(F)c2F)c2ccccc2O1
Show InChI InChI=1S/C22H22F2N2O3/c23-15-7-5-6-14(21(15)24)12-26-13-20(29-19-11-4-2-9-17(19)26)22(28)25-16-8-1-3-10-18(16)27/h2,4-7,9,11,13,16,18,27H,1,3,8,10,12H2,(H,25,28)/t16-,18-/m0/s1
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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395177
PNG
(US10308620, Example 23)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccncc2)c2ccccc2O1
Show InChI InChI=1S/C21H23N3O3/c25-18-7-3-1-5-16(18)23-21(26)20-14-24(13-15-9-11-22-12-10-15)17-6-2-4-8-19(17)27-20/h2,4,6,8-12,14,16,18,25H,1,3,5,7,13H2,(H,23,26)/t16-,18-/m0/s1
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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395178
PNG
(US10308620, Example 24)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccnc(Cl)c2)c2ccccc2O1
Show InChI InChI=1S/C21H22ClN3O3/c22-20-11-14(9-10-23-20)12-25-13-19(28-18-8-4-2-6-16(18)25)21(27)24-15-5-1-3-7-17(15)26/h2,4,6,8-11,13,15,17,26H,1,3,5,7,12H2,(H,24,27)/t15-,17-/m0/s1
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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395183
PNG
(US10308620, Example 29)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2cccc(F)c2F)c2cccc(F)c2O1
Show InChI InChI=1S/C22H21F3N2O3/c23-14-6-3-5-13(20(14)25)11-27-12-19(30-21-15(24)7-4-9-17(21)27)22(29)26-16-8-1-2-10-18(16)28/h3-7,9,12,16,18,28H,1-2,8,10-11H2,(H,26,29)/t16-,18-/m0/s1
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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395188
PNG
(US10308620, Example 35)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccc(F)cc2)c2ncccc2O1
Show InChI InChI=1S/C21H22FN3O3/c22-15-9-7-14(8-10-15)12-25-13-19(28-18-6-3-11-23-20(18)25)21(27)24-16-4-1-2-5-17(16)26/h3,6-11,13,16-17,26H,1-2,4-5,12H2,(H,24,27)/t16-,17-/m0/s1
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n/an/an/an/a 1.58E+3n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395205
PNG
(US10308620, Example 54)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccnc(Cl)c2)c2cccc(F)c2O1
Show InChI InChI=1S/C21H21ClFN3O3/c22-19-10-13(8-9-24-19)11-26-12-18(29-20-14(23)4-3-6-16(20)26)21(28)25-15-5-1-2-7-17(15)27/h3-4,6,8-10,12,15,17,27H,1-2,5,7,11H2,(H,25,28)/t15-,17-/m0/s1
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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395207
PNG
(US10308620, Example 56)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccccn2)c2c(F)cccc2O1
Show InChI InChI=1S/C21H22FN3O3/c22-15-7-5-10-18-20(15)25(12-14-6-3-4-11-23-14)13-19(28-18)21(27)24-16-8-1-2-9-17(16)26/h3-7,10-11,13,16-17,26H,1-2,8-9,12H2,(H,24,27)/t16-,17-/m0/s1
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SUVEN LIFE SCIENCES LIMITED

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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395157
PNG
(US10308620, Example 3)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccccc2F)c2ncccc2O1
Show InChI InChI=1S/C21H22FN3O3/c22-15-7-2-1-6-14(15)12-25-13-19(28-18-10-5-11-23-20(18)25)21(27)24-16-8-3-4-9-17(16)26/h1-2,5-7,10-11,13,16-17,26H,3-4,8-9,12H2,(H,24,27)/t16-,17-/m0/s1
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n/an/an/an/a 1.15E+3n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395160
PNG
(US10308620, Example 6)
Show SMILES COc1ccc(CN2C=C(Oc3ccccc23)C(=O)NCC(C)(C)O)cc1
Show InChI InChI=1S/C21H24N2O4/c1-21(2,25)14-22-20(24)19-13-23(17-6-4-5-7-18(17)27-19)12-15-8-10-16(26-3)11-9-15/h4-11,13,25H,12,14H2,1-3H3,(H,22,24)
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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395163
PNG
(US10308620, Example 9)
Show SMILES COc1cccc(CN2C=C(Oc3ccccc23)C(=O)N[C@H]2CCCC[C@@H]2O)c1
Show InChI InChI=1S/C23H26N2O4/c1-28-17-8-6-7-16(13-17)14-25-15-22(29-21-12-5-3-10-19(21)25)23(27)24-18-9-2-4-11-20(18)26/h3,5-8,10,12-13,15,18,20,26H,2,4,9,11,14H2,1H3,(H,24,27)/t18-,20-/m0/s1
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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395169
PNG
(US10308620, Example 15)
Show SMILES COc1ccc(CN2C=C(Oc3ccccc23)C(=O)N[C@H]2CCCC[C@@H]2O)cn1
Show InChI InChI=1S/C22H25N3O4/c1-28-21-11-10-15(12-23-21)13-25-14-20(29-19-9-5-3-7-17(19)25)22(27)24-16-6-2-4-8-18(16)26/h3,5,7,9-12,14,16,18,26H,2,4,6,8,13H2,1H3,(H,24,27)/t16-,18-/m0/s1
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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395180
PNG
(US10308620, Example 26)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccc(Cl)c(Cl)c2)c2ccccc2O1
Show InChI InChI=1S/C22H22Cl2N2O3/c23-15-10-9-14(11-16(15)24)12-26-13-21(29-20-8-4-2-6-18(20)26)22(28)25-17-5-1-3-7-19(17)27/h2,4,6,8-11,13,17,19,27H,1,3,5,7,12H2,(H,25,28)/t17-,19-/m0/s1
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Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395182
PNG
(US10308620, Example 28)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccc(Cl)cc2Cl)c2ccccc2O1
Show InChI InChI=1S/C22H22Cl2N2O3/c23-15-10-9-14(16(24)11-15)12-26-13-21(29-20-8-4-2-6-18(20)26)22(28)25-17-5-1-3-7-19(17)27/h2,4,6,8-11,13,17,19,27H,1,3,5,7,12H2,(H,25,28)/t17-,19-/m0/s1
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US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395185
PNG
(US10308620, Example 31)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccccc2)c2cccnc2O1
Show InChI InChI=1S/C21H23N3O3/c25-18-11-5-4-9-16(18)23-20(26)19-14-24(13-15-7-2-1-3-8-15)17-10-6-12-22-21(17)27-19/h1-3,6-8,10,12,14,16,18,25H,4-5,9,11,13H2,(H,23,26)/t16-,18-/m0/s1
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US Patent
n/an/an/an/a 1.00E+3n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395204
PNG
(US10308620, Example 53)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccnc(c2)-c2ccccc2)c2cccc(F)c2O1
Show InChI InChI=1S/C27H26FN3O3/c28-20-9-6-11-23-26(20)34-25(27(33)30-21-10-4-5-12-24(21)32)17-31(23)16-18-13-14-29-22(15-18)19-7-2-1-3-8-19/h1-3,6-9,11,13-15,17,21,24,32H,4-5,10,12,16H2,(H,30,33)/t21-,24-/m0/s1
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n/an/an/an/a 230n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395211
PNG
(US10308620, Example 61)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccccc2F)c2c(F)ccc(F)c2O1
Show InChI InChI=1S/C22H21F3N2O3/c23-14-6-2-1-5-13(14)11-27-12-19(22(29)26-17-7-3-4-8-18(17)28)30-21-16(25)10-9-15(24)20(21)27/h1-2,5-6,9-10,12,17-18,28H,3-4,7-8,11H2,(H,26,29)/t17-,18-/m0/s1
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n/an/an/an/a 219n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395214
PNG
(N-(3-Hydroxypiperidin-4-yl)-4-(2,3-difluorobenzyl)...)
Show SMILES OC1CNCCC1NC(=O)C1=CN(Cc2cccc(F)c2F)c2cccc(F)c2O1
Show InChI InChI=1S/C21H20F3N3O3/c22-13-4-1-3-12(19(13)24)10-27-11-18(30-20-14(23)5-2-6-16(20)27)21(29)26-15-7-8-25-9-17(15)28/h1-6,11,15,17,25,28H,7-10H2,(H,26,29)
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n/an/an/an/a 160n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395217
PNG
(US10308620, Example 86)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2cccc(F)c2)c2ccccc2S1
Show InChI InChI=1S/C22H23FN2O2S/c23-16-7-5-6-15(12-16)13-25-14-21(28-20-11-4-2-9-18(20)25)22(27)24-17-8-1-3-10-19(17)26/h2,4-7,9,11-12,14,17,19,26H,1,3,8,10,13H2,(H,24,27)/t17-,19-/m0/s1
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n/an/an/an/a 936n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395223
PNG
(US10308620, Example 92)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccccn2)c2ccccc2S1
Show InChI InChI=1S/C21H23N3O2S/c25-18-10-3-1-8-16(18)23-21(26)20-14-24(13-15-7-5-6-12-22-15)17-9-2-4-11-19(17)27-20/h2,4-7,9,11-12,14,16,18,25H,1,3,8,10,13H2,(H,23,26)/t16-,18-/m0/s1
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n/an/an/an/a 1.47E+3n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM395225
PNG
(US10308620, Example 94)
Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)C1=CN(Cc2ccccc2)c2ccccc2S1=O
Show InChI InChI=1S/C22H24N2O3S/c25-19-12-6-4-10-17(19)23-22(26)21-15-24(14-16-8-2-1-3-9-16)18-11-5-7-13-20(18)28(21)27/h1-3,5,7-9,11,13,15,17,19,25H,4,6,10,12,14H2,(H,23,26)/t17-,19-,28?/m0/s1
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n/an/an/an/a 1.40E+3n/an/an/an/a



SUVEN LIFE SCIENCES LIMITED

US Patent


Assay Description
A stable CHO cell line expressing recombinant human Muscarinic M1 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offe...


US Patent US10308620 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%