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Patent code US10308636

Compile Data Set for Download or QSAR
Found 80 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395359
PNG
(US10308636, Example 44-6)
Show SMILES OC(=O)c1cccc(OCC2CCN(CC2)c2ccc(cn2)-c2nc(c[nH]2)C(F)(F)F)c1Cl
Show InChI InChI=1S/C22H20ClF3N4O3/c23-19-15(21(31)32)2-1-3-16(19)33-12-13-6-8-30(9-7-13)18-5-4-14(10-27-18)20-28-11-17(29-20)22(24,25)26/h1-5,10-11,13H,6-9,12H2,(H,28,29)(H,31,32)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395327
PNG
(US10308636, Example 4-15)
Show SMILES CCC(CC)(COc1cnc(cn1)-c1ccc(nc1)-c1ncc([nH]1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C25H25N5O3/c1-3-25(4-2,24(31)32)16-33-22-15-27-20(13-28-22)18-10-11-19(26-12-18)23-29-14-21(30-23)17-8-6-5-7-9-17/h5-15H,3-4,16H2,1-2H3,(H,29,30)(H,31,32)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395378
PNG
(US10308636, Example 110)
Show SMILES COC(=O)C(C)(C)COc1ccc(cn1)-c1ccc(cc1)-c1nc(n[nH]1)-c1ccc(OC)cc1
Show InChI InChI=1S/C26H26N4O4/c1-26(2,25(31)33-4)16-34-22-14-11-20(15-27-22)17-5-7-18(8-6-17)23-28-24(30-29-23)19-9-12-21(32-3)13-10-19/h5-15H,16H2,1-4H3,(H,28,29,30)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395380
PNG
(US10308636, Example 75)
Show SMILES COC(=O)C(C)(C)COc1ccc(cn1)-c1ccc(cc1)-c1nc(Oc2ccc(cc2)C#N)n(COCC[Si](C)(C)C)n1
Show InChI InChI=1S/C32H37N5O5Si/c1-32(2,30(38)39-3)21-41-28-16-13-26(20-34-28)24-9-11-25(12-10-24)29-35-31(42-27-14-7-23(19-33)8-15-27)37(36-29)22-40-17-18-43(4,5)6/h7-16,20H,17-18,21-22H2,1-6H3
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395381
PNG
(US10308636, Example 74)
Show SMILES COC(=O)C(C)(C)COc1ccc(cn1)-c1ccc(cc1)-c1nc(OCC(F)(F)C(F)(F)F)n(COCC[Si](C)(C)C)n1
Show InChI InChI=1S/C28H35F5N4O5Si/c1-26(2,24(38)39-3)16-41-22-12-11-21(15-34-22)19-7-9-20(10-8-19)23-35-25(42-17-27(29,30)28(31,32)33)37(36-23)18-40-13-14-43(4,5)6/h7-12,15H,13-14,16-18H2,1-6H3
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395364
PNG
(US10308636, Example 46-5)
Show SMILES Fc1ccccc1OC[C@H]1CC[C@@H](CC1)c1ccc(cn1)-c1nc(c[nH]1)C(F)(F)F
Show InChI InChI=1/C22H21F4N3O/c23-17-3-1-2-4-19(17)30-13-14-5-7-15(8-6-14)18-10-9-16(11-27-18)21-28-12-20(29-21)22(24,25)26/h1-4,9-12,14-15H,5-8,13H2,(H,28,29)/t14-,15-
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395361
PNG
(US10308636, Example 45-1)
Show SMILES CCOC(=O)c1cccc(OCC2CCN(CC2)c2ccc(cc2)-c2nc(cn2COCC[Si](C)(C)C)C(F)(F)F)c1C
Show InChI InChI=1S/C32H42F3N3O4Si/c1-6-41-31(39)27-8-7-9-28(23(27)2)42-21-24-14-16-37(17-15-24)26-12-10-25(11-13-26)30-36-29(32(33,34)35)20-38(30)22-40-18-19-43(3,4)5/h7-13,20,24H,6,14-19,21-22H2,1-5H3
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395345
PNG
(US10308636, Example 32-2)
Show SMILES Cc1cc(OCC(C)(C)C(O)=O)ncc1-c1ccc(cc1)-c1nc(c[nH]1)C#N
Show InChI InChI=1S/C21H20N4O3/c1-13-8-18(28-12-21(2,3)20(26)27)23-11-17(13)14-4-6-15(7-5-14)19-24-10-16(9-22)25-19/h4-8,10-11H,12H2,1-3H3,(H,24,25)(H,26,27)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395383
PNG
(US10308636, Example 78)
Show SMILES NC(=O)c1ccc(Br)cc1F
Show InChI InChI=1S/C7H5BrFNO/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3H,(H2,10,11)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395325
PNG
(US10308636, Example 4-1)
Show SMILES Cc1cc(OCC(C)(C)C(=O)OC(C)(C)C)ncc1-c1cnc(-c2ncc([nH]2)-c2ccccc2)c(F)c1
Show InChI InChI=1S/C29H31FN4O3/c1-18-12-24(36-17-29(5,6)27(35)37-28(2,3)4)31-15-21(18)20-13-22(30)25(32-14-20)26-33-16-23(34-26)19-10-8-7-9-11-19/h7-16H,17H2,1-6H3,(H,33,34)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395386
PNG
(US10308636, Example 83)
Show SMILES C[Si](C)(C)CCOCn1nc(nc1Oc1ccc(F)cc1)-c1ccc(Br)cc1F
Show InChI InChI=1S/C20H22BrF2N3O2Si/c1-29(2,3)11-10-27-13-26-20(28-16-7-5-15(22)6-8-16)24-19(25-26)17-9-4-14(21)12-18(17)23/h4-9,12H,10-11,13H2,1-3H3
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395313
PNG
(US10308636, Example 1-34)
Show SMILES CC(C)(COc1ccc(cc1)-c1ccc(cn1)-c1ncc([nH]1)-c1cccs1)C(O)=O
Show InChI InChI=1S/C23H21N3O3S/c1-23(2,22(27)28)14-29-17-8-5-15(6-9-17)18-10-7-16(12-24-18)21-25-13-19(26-21)20-4-3-11-30-20/h3-13H,14H2,1-2H3,(H,25,26)(H,27,28)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395326
PNG
(US10308636, Example 4-3)
Show SMILES Cc1cc(OCC2(CCC2)C(O)=O)ncc1-c1cnc(nc1)-c1ncc([nH]1)-c1ccccc1
Show InChI InChI=1S/C25H23N5O3/c1-16-10-21(33-15-25(24(31)32)8-5-9-25)26-13-19(16)18-11-27-22(28-12-18)23-29-14-20(30-23)17-6-3-2-4-7-17/h2-4,6-7,10-14H,5,8-9,15H2,1H3,(H,29,30)(H,31,32)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395379
PNG
(US10308636, Example 72)
Show SMILES COC(=O)C(C)(C)COc1ccc(cn1)-c1ccc(cc1)-c1nc(Oc2cccnc2)n(COCC[Si](C)(C)C)n1
Show InChI InChI=1S/C30H37N5O5Si/c1-30(2,28(36)37-3)20-39-26-14-13-24(18-32-26)22-9-11-23(12-10-22)27-33-29(40-25-8-7-15-31-19-25)35(34-27)21-38-16-17-41(4,5)6/h7-15,18-19H,16-17,20-21H2,1-6H3
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395324
PNG
(US10308636, Example 3-7)
Show SMILES Cc1cc(OCC2(CC2)C(O)=O)ncc1-c1cnc(-c2ncc([nH]2)-c2ccccc2OC(F)(F)F)c(F)c1
Show InChI InChI=1S/C26H20F4N4O4/c1-14-8-21(37-13-25(6-7-25)24(35)36)31-11-17(14)15-9-18(27)22(32-10-15)23-33-12-19(34-23)16-4-2-3-5-20(16)38-26(28,29)30/h2-5,8-12H,6-7,13H2,1H3,(H,33,34)(H,35,36)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395320
PNG
(US10308636, Example 2-7)
Show SMILES CC(C)(COc1ccc(cn1)-c1ccc(cc1)-c1ncc([nH]1)-c1ccccc1)C([O-])=O
Show InChI InChI=1S/C25H23N3O3/c1-25(2,24(29)30)16-31-22-13-12-20(14-26-22)17-8-10-19(11-9-17)23-27-15-21(28-23)18-6-4-3-5-7-18/h3-15H,16H2,1-2H3,(H,27,28)(H,29,30)/p-1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395372
PNG
(US10308636, Example 59)
Show SMILES Brc1ccc(cc1)-c1nnc([nH]1)-c1ccccc1
Show InChI InChI=1S/C14H10BrN3/c15-12-8-6-11(7-9-12)14-16-13(17-18-14)10-4-2-1-3-5-10/h1-9H,(H,16,17,18)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395347
PNG
(US10308636, Example 35-1)
Show SMILES FC(F)(F)c1cnc([nH]1)-c1ccc(nc1)N1CCN(CC1)C(=O)Cc1ccccc1Cl
Show InChI InChI=1S/C21H19ClF3N5O/c22-16-4-2-1-3-14(16)11-19(31)30-9-7-29(8-10-30)18-6-5-15(12-26-18)20-27-13-17(28-20)21(23,24)25/h1-6,12-13H,7-11H2,(H,27,28)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395321
PNG
(US10308636, Example 2-8)
Show SMILES COc1ccc(cc1)-c1cnc([nH]1)-c1ccc(cc1)-c1ccc(OCC(C)(C)C([O-])=O)nc1
Show InChI InChI=1S/C26H25N3O4/c1-26(2,25(30)31)16-33-23-13-10-20(14-27-23)17-4-6-19(7-5-17)24-28-15-22(29-24)18-8-11-21(32-3)12-9-18/h4-15H,16H2,1-3H3,(H,28,29)(H,30,31)/p-1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395337
PNG
(US10308636, Example 17)
Show SMILES COC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc(cn1)-c1ncc(n1COCC[Si](C)(C)C)C(F)(F)F
Show InChI InChI=1S/C30H38F3N3O3Si/c1-38-28(37)17-21-5-7-22(8-6-21)23-9-11-24(12-10-23)26-14-13-25(18-34-26)29-35-19-27(30(31,32)33)36(29)20-39-15-16-40(2,3)4/h9-14,18-19,21-22H,5-8,15-17,20H2,1-4H3/t21-,22-
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395328
PNG
(US10308636, Example 5-2)
Show SMILES Cc1cc(OCC(C)(C)C(O)=O)ncc1-c1cnc(nc1)-c1ncc([nH]1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C25H22F3N5O3/c1-14-8-20(36-13-24(2,3)23(34)35)29-11-17(14)15-9-30-21(31-10-15)22-32-12-19(33-22)16-6-4-5-7-18(16)25(26,27)28/h4-12H,13H2,1-3H3,(H,32,33)(H,34,35)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395336
PNG
(US10308636, Example 14)
Show SMILES COc1ccc(cc1)-c1cn(COCC[Si](C)(C)C)c(n1)-c1ccc(cc1Cl)-c1cnc(OCC(C)(C)C)cc1C
Show InChI InChI=1S/C33H42ClN3O3Si/c1-23-17-31(40-21-33(2,3)4)35-19-28(23)25-11-14-27(29(34)18-25)32-36-30(24-9-12-26(38-5)13-10-24)20-37(32)22-39-15-16-41(6,7)8/h9-14,17-20H,15-16,21-22H2,1-8H3
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395384
PNG
(US10308636, Example 80)
Show SMILES CSC(SC)=NC(=O)c1ccc(Cl)nc1
Show InChI InChI=1S/C9H9ClN2OS2/c1-14-9(15-2)12-8(13)6-3-4-7(10)11-5-6/h3-5H,1-2H3
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n/an/a 3.30n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395388
PNG
(US10308636, Example 23-1)
Show SMILES COC[C@@]1(CC[C@@H](CC1)Oc1ccc(cc1)-c1ccc(cn1)-c1nc(C)c(n1)C(F)(F)F)C(O)=O
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395318
PNG
(US10308636, Example 1-63)
Show SMILES Cc1cc(OCC2(CC2)C(O)=O)ncc1-c1ccc(nc1)-c1ncc([nH]1)-c1ccccc1OC(F)(F)F
Show InChI InChI=1S/C26H21F3N4O4/c1-15-10-22(36-14-25(8-9-25)24(34)35)31-12-18(15)16-6-7-19(30-11-16)23-32-13-20(33-23)17-4-2-3-5-21(17)37-26(27,28)29/h2-7,10-13H,8-9,14H2,1H3,(H,32,33)(H,34,35)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395322
PNG
(US10308636, Example 2-11)
Show SMILES COc1ccc(cc1)-c1cnc([nH]1)-c1ccc(cc1)-c1cnc(OCC(C)(C)C([O-])=O)cc1C
Show InChI InChI=1S/C27H27N3O4/c1-17-13-24(34-16-27(2,3)26(31)32)28-14-22(17)18-5-7-20(8-6-18)25-29-15-23(30-25)19-9-11-21(33-4)12-10-19/h5-15H,16H2,1-4H3,(H,29,30)(H,31,32)/p-1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395375
PNG
(US10308636, Example 67)
Show SMILES CCOC(=O)[C@@H]1CC[C@@H](CC1)Oc1ccc(cn1)-c1ccc(cc1)-c1nc(OCC)n(COCC[Si](C)(C)C)n1
Show InChI InChI=1S/C30H42N4O5Si/c1-6-37-29(35)24-12-15-26(16-13-24)39-27-17-14-25(20-31-27)22-8-10-23(11-9-22)28-32-30(38-7-2)34(33-28)21-36-18-19-40(3,4)5/h8-11,14,17,20,24,26H,6-7,12-13,15-16,18-19,21H2,1-5H3/t24-,26+
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395316
PNG
(US10308636, Example 1-44)
Show SMILES Cc1cc(ccc1-c1ncc([nH]1)-c1ccccc1)-c1ccc(OCC(C)(C)C(O)=O)nc1
Show InChI InChI=1S/C26H25N3O3/c1-17-13-19(20-10-12-23(27-14-20)32-16-26(2,3)25(30)31)9-11-21(17)24-28-15-22(29-24)18-7-5-4-6-8-18/h4-15H,16H2,1-3H3,(H,28,29)(H,30,31)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395348
PNG
(US10308636, Example 37-3)
Show SMILES Cc1[nH]c(nc1C#N)-c1ccc(nc1)N1CCN(CC1)c1ccc(C)cc1
Show InChI InChI=1S/C21H22N6/c1-15-3-6-18(7-4-15)26-9-11-27(12-10-26)20-8-5-17(14-23-20)21-24-16(2)19(13-22)25-21/h3-8,14H,9-12H2,1-2H3,(H,24,25)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395363
PNG
(US10308636, Example 46-4)
Show SMILES Cc1ccc(OC[C@H]2CC[C@@H](CC2)c2ccc(cn2)-c2nc(c[nH]2)C(F)(F)F)cc1
Show InChI InChI=1/C23H24F3N3O/c1-15-2-9-19(10-3-15)30-14-16-4-6-17(7-5-16)20-11-8-18(12-27-20)22-28-13-21(29-22)23(24,25)26/h2-3,8-13,16-17H,4-7,14H2,1H3,(H,28,29)/t16-,17-
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395385
PNG
(US10308636, Example 82)
Show SMILES C[Si](C)(C)CCOCn1nc(nc1OCC(F)(F)F)-c1ccc(Br)cc1F
Show InChI InChI=1S/C16H20BrF4N3O2Si/c1-27(2,3)7-6-25-10-24-15(26-9-16(19,20)21)22-14(23-24)12-5-4-11(17)8-13(12)18/h4-5,8H,6-7,9-10H2,1-3H3
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395335
PNG
(US10308636, Example 12)
Show SMILES COC(=O)C(C)(C)COc1ccc(cc1)-c1ccc(cn1)-c1nc(Cl)c([nH]1)-c1ccccc1
Show InChI InChI=1S/C26H24ClN3O3/c1-26(2,25(31)32-3)16-33-20-12-9-17(10-13-20)21-14-11-19(15-28-21)24-29-22(23(27)30-24)18-7-5-4-6-8-18/h4-15H,16H2,1-3H3,(H,29,30)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395376
PNG
(US10308636, Example 108)
Show SMILES NNC(=O)C1(CC1)C(F)(F)F
Show InChI InChI=1S/C5H7F3N2O/c6-5(7,8)4(1-2-4)3(11)10-9/h1-2,9H2,(H,10,11)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395374
PNG
(US10308636, Example 61)
Show SMILES Nc1nnc(o1)-c1ccc(Br)cc1
Show InChI InChI=1S/C8H6BrN3O/c9-6-3-1-5(2-4-6)7-11-12-8(10)13-7/h1-4H,(H2,10,12)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395323
PNG
(US10308636, Example 2-16)
Show SMILES COc1nc([nH]c1-c1ccccc1)-c1ccc(nc1)-c1ccc(OCC(C)(C)C([O-])=O)cc1
Show InChI InChI=1S/C26H25N3O4/c1-26(2,25(30)31)16-33-20-12-9-17(10-13-20)21-14-11-19(15-27-21)23-28-22(24(29-23)32-3)18-7-5-4-6-8-18/h4-15H,16H2,1-3H3,(H,28,29)(H,30,31)/p-1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395331
PNG
(US10308636, Example 8)
Show SMILES COC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc(cn1)-c1nc(cn1COCC[Si](C)(C)C)-c1ccccc1
Show InChI InChI=1S/C35H43N3O3Si/c1-40-34(39)22-26-10-12-27(13-11-26)28-14-16-30(17-15-28)32-19-18-31(23-36-32)35-37-33(29-8-6-5-7-9-29)24-38(35)25-41-20-21-42(2,3)4/h5-9,14-19,23-24,26-27H,10-13,20-22,25H2,1-4H3/t26-,27-
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395333
PNG
(US10308636, Example 10)
Show SMILES COc1ccc(COc2ccc(cc2)-c2ccc(cn2)-c2nc(cn2COCC[Si](C)(C)C)C(=O)OCc2ccccc2)cc1
Show InChI InChI=1S/C36H39N3O5Si/c1-41-31-15-10-28(11-16-31)24-43-32-17-12-29(13-18-32)33-19-14-30(22-37-33)35-38-34(23-39(35)26-42-20-21-45(2,3)4)36(40)44-25-27-8-6-5-7-9-27/h5-19,22-23H,20-21,24-26H2,1-4H3
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395344
PNG
(US10308636, Example 31-2)
Show SMILES CCOCc1nc([nH]c1Cl)-c1ccc(nc1)-c1ccc(OCC(C)(C)C(O)=O)cc1
Show InChI InChI=1S/C22H24ClN3O4/c1-4-29-12-18-19(23)26-20(25-18)15-7-10-17(24-11-15)14-5-8-16(9-6-14)30-13-22(2,3)21(27)28/h5-11H,4,12-13H2,1-3H3,(H,25,26)(H,27,28)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395387
PNG
(US10308636, Example 104)
Show SMILES COC(=O)C(C)(C)COc1ccc(cn1)B1OC(C)(C)C(C)(C)O1
Show InChI InChI=1S/C17H26BNO5/c1-15(2,14(20)21-7)11-22-13-9-8-12(10-19-13)18-23-16(3,4)17(5,6)24-18/h8-10H,11H2,1-7H3
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395309
PNG
(US10308636, Example 1-3)
Show SMILES CC(C)(COc1ccc(cc1)-c1ccc(cn1)-c1ncc([nH]1)-c1cccc(F)c1)C(O)=O
Show InChI InChI=1S/C25H22FN3O3/c1-25(2,24(30)31)15-32-20-9-6-16(7-10-20)21-11-8-18(13-27-21)23-28-14-22(29-23)17-4-3-5-19(26)12-17/h3-14H,15H2,1-2H3,(H,28,29)(H,30,31)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395338
PNG
(US10308636, Example 21-2)
Show SMILES OC(=O)C[C@H]1CCC[C@@H](C1)Oc1ccc(cc1)-c1ccc(cn1)-c1nc(c[nH]1)C(F)(F)F
Show InChI InChI=1/C23H22F3N3O3/c24-23(25,26)20-13-28-22(29-20)16-6-9-19(27-12-16)15-4-7-17(8-5-15)32-18-3-1-2-14(10-18)11-21(30)31/h4-9,12-14,18H,1-3,10-11H2,(H,28,29)(H,30,31)/t14-,18-/s2
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395332
PNG
(US10308636, Example 9)
Show SMILES CC1(C)OB(OC1(C)C)c1ccc(nc1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C24H26BNO3/c1-23(2)24(3,4)29-25(28-23)20-12-15-22(26-16-20)19-10-13-21(14-11-19)27-17-18-8-6-5-7-9-18/h5-16H,17H2,1-4H3
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395308
PNG
(US10308636, Example 1-1)
Show SMILES CC(C)(COc1ccc(cc1)-c1ccc(cn1)-c1ncc([nH]1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C25H23N3O3/c1-25(2,24(29)30)16-31-20-11-8-18(9-12-20)21-13-10-19(14-26-21)23-27-15-22(28-23)17-6-4-3-5-7-17/h3-15H,16H2,1-2H3,(H,27,28)(H,29,30)
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n/an/a 8n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395370
PNG
(US10308636, Example 55)
Show SMILES COC[C@@]1(CC[C@@H](CC1)Oc1ccc(Br)cn1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C18H26BrNO4/c1-17(2,3)24-16(21)18(12-22-4)9-7-14(8-10-18)23-15-6-5-13(19)11-20-15/h5-6,11,14H,7-10,12H2,1-4H3/t14-,18-
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n/an/a 8.10n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395366
PNG
(US10308636, Example 48)
Show SMILES CCOC(=O)Cc1ccc(cc1)C1CCC(CC1)c1ccc(cn1)-c1nc(cn1COCC[Si](C)(C)C)C(F)(F)F
Show InChI InChI=1S/C31H40F3N3O3Si/c1-5-40-29(38)18-22-6-8-23(9-7-22)24-10-12-25(13-11-24)27-15-14-26(19-35-27)30-36-28(31(32,33)34)20-37(30)21-39-16-17-41(2,3)4/h6-9,14-15,19-20,24-25H,5,10-13,16-18,21H2,1-4H3
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n/an/a 8.20n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395355
PNG
(US10308636, Example 43-1)
Show SMILES Cc1cccc(OCC2CCN(CC2)c2ccc(cn2)-c2nc(cn2COCC[Si](C)(C)C)C(F)(F)F)c1
Show InChI InChI=1S/C28H37F3N4O2Si/c1-21-6-5-7-24(16-21)37-19-22-10-12-34(13-11-22)26-9-8-23(17-32-26)27-33-25(28(29,30)31)18-35(27)20-36-14-15-38(2,3)4/h5-9,16-18,22H,10-15,19-20H2,1-4H3
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n/an/a 8.5n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395346
PNG
(US10308636, Example 34)
Show SMILES C[Si](C)(C)CCOCn1cc(nc1-c1ccc(nc1)-c1ccc(OCc2ccccc2)cc1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C35H37N3O4Si/c1-43(2,3)21-20-40-26-38-23-33(35(39)42-25-28-12-8-5-9-13-28)37-34(38)30-16-19-32(36-22-30)29-14-17-31(18-15-29)41-24-27-10-6-4-7-11-27/h4-19,22-23H,20-21,24-26H2,1-3H3
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n/an/a 8.80n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395362
PNG
(US10308636, Example 46-1)
Show SMILES CCOC(=O)C1CCC(CC1)c1ccc(cn1)-c1nc(cn1COCC[Si](C)(C)C)C(F)(F)F
Show InChI InChI=1S/C24H34F3N3O3Si/c1-5-33-23(31)18-8-6-17(7-9-18)20-11-10-19(14-28-20)22-29-21(24(25,26)27)15-30(22)16-32-12-13-34(2,3)4/h10-11,14-15,17-18H,5-9,12-13,16H2,1-4H3
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395365
PNG
(US10308636, Example 47-1)
Show SMILES Cc1ccnc(OC[C@H]2CC[C@@H](CC2)c2ccc(cn2)-c2nc(cn2COCC[Si](C)(C)C)C(F)(F)F)c1
Show InChI InChI=1S/C28H37F3N4O2Si/c1-20-11-12-32-26(15-20)37-18-21-5-7-22(8-6-21)24-10-9-23(16-33-24)27-34-25(28(29,30)31)17-35(27)19-36-13-14-38(2,3)4/h9-12,15-17,21-22H,5-8,13-14,18-19H2,1-4H3/t21-,22-
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n/an/a 9n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395329
PNG
(US10308636, Example 6)
Show SMILES COC(=O)C(C)(C)COc1ccc(cc1)-c1ccc(cn1)-c1nc(cn1COCC[Si](C)(C)C)-c1cccc(c1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C40H45N3O6Si/c1-40(2,39(45)46-3)27-49-34-18-15-30(16-19-34)35-20-17-33(24-41-35)37-42-36(25-43(37)28-47-21-22-50(4,5)6)31-13-10-14-32(23-31)38(44)48-26-29-11-8-7-9-12-29/h7-20,23-25H,21-22,26-28H2,1-6H3
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n/an/a 9.10n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395317
PNG
(US10308636, Example 1-58)
Show SMILES CC(C)(COc1ccc(cc1)-c1ccc(cn1)-c1ncc(CCOc2ccccc2)[nH]1)C(O)=O
Show InChI InChI=1S/C27H27N3O4/c1-27(2,26(31)32)18-34-23-11-8-19(9-12-23)24-13-10-20(16-28-24)25-29-17-21(30-25)14-15-33-22-6-4-3-5-7-22/h3-13,16-17H,14-15,18H2,1-2H3,(H,29,30)(H,31,32)
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n/an/a 11n/an/an/an/an/an/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395315
PNG
(US10308636, Example 1-37)
Show SMILES Cc1cc(on1)-c1cnc([nH]1)-c1ccc(nc1)-c1ccc(OCC(C)(C)C(O)=O)cc1
Show InChI InChI=1S/C23H22N4O4/c1-14-10-20(31-27-14)19-12-25-21(26-19)16-6-9-18(24-11-16)15-4-7-17(8-5-15)30-13-23(2,3)22(28)29/h4-12H,13H2,1-3H3,(H,25,26)(H,28,29)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395310
PNG
(US10308636, Example 1-17)
Show SMILES CC(C)(COc1ccc(cc1)-c1ccc(cn1)-c1ncc([nH]1)-c1ccccc1OCCCO)C(O)=O
Show InChI InChI=1S/C28H29N3O5/c1-28(2,27(33)34)18-36-21-11-8-19(9-12-21)23-13-10-20(16-29-23)26-30-17-24(31-26)22-6-3-4-7-25(22)35-15-5-14-32/h3-4,6-13,16-17,32H,5,14-15,18H2,1-2H3,(H,30,31)(H,33,34)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395330
PNG
(US10308636, Example 7)
Show SMILES COC(=O)C(C)(C)COc1ccc(cc1)-c1ccc(cn1)-c1nc(cn1COCC[Si](C)(C)C)-c1noc(C)n1
Show InChI InChI=1S/C29H37N5O5Si/c1-20-31-26(33-39-20)25-17-34(19-37-14-15-40(5,6)7)27(32-25)22-10-13-24(30-16-22)21-8-11-23(12-9-21)38-18-29(2,3)28(35)36-4/h8-13,16-17H,14-15,18-19H2,1-7H3
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395353
PNG
(US10308636, Example 40-1)
Show SMILES CC1(C)OCC(COC(=O)Cc2ccc(cc2)N2CCN(CC2)c2ccc(cn2)-c2nc(c[nH]2)C(F)(F)F)O1
Show InChI InChI=1/C27H30F3N5O4/c1-26(2)38-17-21(39-26)16-37-24(36)13-18-3-6-20(7-4-18)34-9-11-35(12-10-34)23-8-5-19(14-31-23)25-32-15-22(33-25)27(28,29)30/h3-8,14-15,21H,9-13,16-17H2,1-2H3,(H,32,33)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395377
PNG
(US10308636, Example 109)
Show SMILES CCCc1n[nH]c(n1)-c1ccc(cc1)-c1ccc(OCC(C)(C)C(=O)OC)nc1
Show InChI InChI=1S/C22H26N4O3/c1-5-6-18-24-20(26-25-18)16-9-7-15(8-10-16)17-11-12-19(23-13-17)29-14-22(2,3)21(27)28-4/h7-13H,5-6,14H2,1-4H3,(H,24,25,26)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395314
PNG
(US10308636, Example 1-35)
Show SMILES CC(C)(COc1ccc(cc1)-c1ccc(cn1)-c1ncc([nH]1)-c1nccs1)C(O)=O
Show InChI InChI=1S/C22H20N4O3S/c1-22(2,21(27)28)13-29-16-6-3-14(4-7-16)17-8-5-15(11-24-17)19-25-12-18(26-19)20-23-9-10-30-20/h3-12H,13H2,1-2H3,(H,25,26)(H,27,28)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395349
PNG
(US10308636, Example 37-4)
Show SMILES Cc1ccc(cc1C)N1CCN(CC1)c1ccc(cn1)-c1nc(c[nH]1)C#N
Show InChI InChI=1S/C21H22N6/c1-15-3-5-19(11-16(15)2)26-7-9-27(10-8-26)20-6-4-17(13-23-20)21-24-14-18(12-22)25-21/h3-6,11,13-14H,7-10H2,1-2H3,(H,24,25)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395342
PNG
(US10308636, Example 29-3)
Show SMILES CC(C)(COc1ccc(cc1)-c1ccc(cn1)-c1nc(Cl)c(Cl)[nH]1)C(O)=O
Show InChI InChI=1S/C19H17Cl2N3O3/c1-19(2,18(25)26)10-27-13-6-3-11(4-7-13)14-8-5-12(9-22-14)17-23-15(20)16(21)24-17/h3-9H,10H2,1-2H3,(H,23,24)(H,25,26)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395368
PNG
(US10308636, Example 51)
Show SMILES COC(=O)C(C)(C)C(=O)OC(C)(C)C
Show InChI InChI=1S/C10H18O4/c1-9(2,3)14-8(12)10(4,5)7(11)13-6/h1-6H3
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395356
PNG
(US10308636, Example 43-2)
Show SMILES OC(=O)Cc1ccc(cc1)C1CCN(CC1)c1ccc(cn1)-c1nc(c[nH]1)C(F)(F)F
Show InChI InChI=1S/C22H21F3N4O2/c23-22(24,25)18-13-27-21(28-18)17-5-6-19(26-12-17)29-9-7-16(8-10-29)15-3-1-14(2-4-15)11-20(30)31/h1-6,12-13,16H,7-11H2,(H,27,28)(H,30,31)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395352
PNG
(US10308636, Example 39)
Show SMILES C[Si](C)(C)CCOCn1cc(nc1-c1ccc(nc1)N1CCN(CC1)c1ccc(CCO)cc1)C(F)(F)F
Show InChI InChI=1S/C27H36F3N5O2Si/c1-38(2,3)17-16-37-20-35-19-24(27(28,29)30)32-26(35)22-6-9-25(31-18-22)34-13-11-33(12-14-34)23-7-4-21(5-8-23)10-15-36/h4-9,18-19,36H,10-17,20H2,1-3H3
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395357
PNG
(US10308636, Example 43-3)
Show SMILES CC(C)(COC1CCN(CC1)c1ccc(cn1)-c1nc(c[nH]1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C19H23F3N4O3/c1-18(2,17(27)28)11-29-13-5-7-26(8-6-13)15-4-3-12(9-23-15)16-24-10-14(25-16)19(20,21)22/h3-4,9-10,13H,5-8,11H2,1-2H3,(H,24,25)(H,27,28)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395311
PNG
(US10308636, Example 1-28)
Show SMILES Cc1cccc(n1)-c1cnc([nH]1)-c1ccc(nc1)-c1ccc(OCC(C)(C)C(O)=O)cc1
Show InChI InChI=1S/C25H24N4O3/c1-16-5-4-6-21(28-16)22-14-27-23(29-22)18-9-12-20(26-13-18)17-7-10-19(11-8-17)32-15-25(2,3)24(30)31/h4-14H,15H2,1-3H3,(H,27,29)(H,30,31)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395367
PNG
(US10308636, Example 49)
Show SMILES C[Si](C)(C)CCOCn1cc(nc1-c1ccc(Br)nc1)C(F)(F)F
Show InChI InChI=1S/C15H19BrF3N3OSi/c1-24(2,3)7-6-23-10-22-9-12(15(17,18)19)21-14(22)11-4-5-13(16)20-8-11/h4-5,8-9H,6-7,10H2,1-3H3
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MITSUBISHI TANABE PHARMA CORPORATION

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Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395358
PNG
(US10308636, Example 43-7)
Show SMILES CC(C)(CCC1CCN(CC1)c1ccc(cn1)-c1nc(c[nH]1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C20H25F3N4O2/c1-19(2,18(28)29)8-5-13-6-9-27(10-7-13)16-4-3-14(11-24-16)17-25-12-15(26-17)20(21,22)23/h3-4,11-13H,5-10H2,1-2H3,(H,25,26)(H,28,29)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395373
PNG
(US10308636, Example 60)
Show SMILES N=C(n1nnc2ccccc12)n1nnc2ccccc12
Show InChI InChI=1S/C13H9N7/c14-13(19-11-7-3-1-5-9(11)15-17-19)20-12-8-4-2-6-10(12)16-18-20/h1-8,14H
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395319
PNG
(US10308636, Example 1-68)
Show SMILES CC(C)Cc1ocnc1-c1cnc([nH]1)-c1ccc(nc1)-c1ccc(OCC(C)(C)C(O)=O)cc1
Show InChI InChI=1S/C26H28N4O4/c1-16(2)11-22-23(29-15-34-22)21-13-28-24(30-21)18-7-10-20(27-12-18)17-5-8-19(9-6-17)33-14-26(3,4)25(31)32/h5-10,12-13,15-16H,11,14H2,1-4H3,(H,28,30)(H,31,32)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395351
PNG
(US10308636, Example 38-5)
Show SMILES Cc1ccc(cc1)N1CCN(CC1)c1ccc(cn1)-c1nc(c[nH]1)C1CCC1
Show InChI InChI=1S/C23H27N5/c1-17-5-8-20(9-6-17)27-11-13-28(14-12-27)22-10-7-19(15-24-22)23-25-16-21(26-23)18-3-2-4-18/h5-10,15-16,18H,2-4,11-14H2,1H3,(H,25,26)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395350
PNG
(US10308636, Example 37-6)
Show SMILES C[C@H]1CN(CCN1c1ccc(cn1)-c1nc(c[nH]1)C#N)c1ccc(C)c(F)c1
Show InChI InChI=1/C21H21FN6/c1-14-3-5-18(9-19(14)22)27-7-8-28(15(2)13-27)20-6-4-16(11-24-20)21-25-12-17(10-23)26-21/h3-6,9,11-12,15H,7-8,13H2,1-2H3,(H,25,26)/t15-/s2
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395369
PNG
(US10308636, Example 52)
Show SMILES CCOC(=N)c1ccc(Cl)nc1
Show InChI InChI=1S/C8H9ClN2O/c1-2-12-8(10)6-3-4-7(9)11-5-6/h3-5,10H,2H2,1H3
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395354
PNG
(US10308636, Example 42)
Show SMILES CC(C)(CCN1CCN(CC1=O)c1ccc(cn1)-c1nc(c[nH]1)C(F)(F)F)C(=O)OCc1ccccc1
Show InChI InChI=1S/C26H28F3N5O3/c1-25(2,24(36)37-17-18-6-4-3-5-7-18)10-11-33-12-13-34(16-22(33)35)21-9-8-19(14-30-21)23-31-15-20(32-23)26(27,28)29/h3-9,14-15H,10-13,16-17H2,1-2H3,(H,31,32)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395360
PNG
(US10308636, Example 44-11)
Show SMILES OC(=O)Cc1cccc(OC2CCN(CC2)c2ccc(cn2)-c2nc(c[nH]2)C(F)(F)F)c1
Show InChI InChI=1S/C22H21F3N4O3/c23-22(24,25)18-13-27-21(28-18)15-4-5-19(26-12-15)29-8-6-16(7-9-29)32-17-3-1-2-14(10-17)11-20(30)31/h1-5,10,12-13,16H,6-9,11H2,(H,27,28)(H,30,31)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395340
PNG
(US10308636, Example 24-2)
Show SMILES CC(C)(C)OCCc1c[nH]c(n1)-c1ccc(nc1)-c1ccc(OCC(C)(C)C(O)=O)cc1
Show InChI InChI=1S/C25H31N3O4/c1-24(2,3)32-13-12-19-15-27-22(28-19)18-8-11-21(26-14-18)17-6-9-20(10-7-17)31-16-25(4,5)23(29)30/h6-11,14-15H,12-13,16H2,1-5H3,(H,27,28)(H,29,30)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395312
PNG
(US10308636, Example 1-31)
Show SMILES CC(C)(COc1ccc(cc1)-c1ccc(cn1)-c1ncc([nH]1)-c1ncccn1)C(O)=O
Show InChI InChI=1S/C23H21N5O3/c1-23(2,22(29)30)14-31-17-7-4-15(5-8-17)18-9-6-16(12-26-18)20-27-13-19(28-20)21-24-10-3-11-25-21/h3-13H,14H2,1-2H3,(H,27,28)(H,29,30)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395382
PNG
(US10308636, Example 77)
Show SMILES COC(=O)C(C)(C)COc1ccc(cn1)-c1ccc(cc1)-c1nc(Oc2cccc(C)n2)n(COCC[Si](C)(C)C)n1
Show InChI InChI=1S/C31H39N5O5Si/c1-22-9-8-10-27(33-22)41-30-34-28(35-36(30)21-39-17-18-42(5,6)7)24-13-11-23(12-14-24)25-15-16-26(32-19-25)40-20-31(2,3)29(37)38-4/h8-16,19H,17-18,20-21H2,1-7H3
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395343
PNG
(US10308636, Example 30)
Show SMILES COC(=O)C(C)(C)COc1ccc(cc1)-c1ccc(cn1)-c1nc(Cl)cn1COCC[Si](C)(C)C
Show InChI InChI=1S/C26H34ClN3O4Si/c1-26(2,25(31)32-3)17-34-21-10-7-19(8-11-21)22-12-9-20(15-28-22)24-29-23(27)16-30(24)18-33-13-14-35(4,5)6/h7-12,15-16H,13-14,17-18H2,1-6H3
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395341
PNG
(US10308636, Example 25)
Show SMILES CN(CC1COC(C)(C)O1)C(=O)C(C)(C)COc1ccc(cc1)-c1ccc(cn1)-c1nc(cn1Cc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C34H37F3N4O4/c1-32(2,31(42)40(5)19-27-21-44-33(3,4)45-27)22-43-26-14-11-24(12-15-26)28-16-13-25(17-38-28)30-39-29(34(35,36)37)20-41(30)18-23-9-7-6-8-10-23/h6-17,20,27H,18-19,21-22H2,1-5H3
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395334
PNG
(US10308636, Example 11)
Show SMILES CN(CC(O)CO)C(=O)C(C)(C)COc1ccc(cc1)-c1ccc(cn1)-c1ncc(-c2ccccc2)n1Cc1ccccc1
Show InChI InChI=1S/C36H38N4O4/c1-36(2,35(43)39(3)23-30(42)24-41)25-44-31-17-14-27(15-18-31)32-19-16-29(20-37-32)34-38-21-33(28-12-8-5-9-13-28)40(34)22-26-10-6-4-7-11-26/h4-21,30,41-42H,22-25H2,1-3H3
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM395371
PNG
(US10308636, Example 57)
Show SMILES COC[C@@]1(CC[C@@H](CC1)Oc1ccc(cn1)-c1ccc(cc1)-c1nnc([nH]1)C(F)(F)F)C(O)=O
Show InChI InChI=1/C23H23F3N4O4/c1-33-13-22(21(31)32)10-8-17(9-11-22)34-18-7-6-16(12-27-18)14-2-4-15(5-3-14)19-28-20(30-29-19)23(24,25)26/h2-7,12,17H,8-11,13H2,1H3,(H,31,32)(H,28,29,30)/t17-,22-
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...


US Patent US10308636 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%